hemin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5117	16009-13-5

Description:

Molecule

Description

Synonyms:

hemin
normosang
panhematin

Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.

Molecular weight: 651.95
Formula: C34H32ClFeN4O4
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 92.22
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Phlebitis	84.20	68.80	14	112	6710	63482186
Device occlusion	69.09	68.80	12	114	7375	63481521

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	96.76	88.00	24	3	419500	34537404

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B06AB01	BLOOD AND BLOOD FORMING ORGANS OTHER HEMATOLOGICAL AGENTS OTHER HEMATOLOGICAL AGENTS Heme products
CHEBI has role	CHEBI:138880	autophagocytosis inducer
CHEBI has role	CHEBI:173085	ferroptosis inducers

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute intermittent porphyria	indication	234422006	DOID:3890

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
743LRP9S7N	UNII
D10003	KEGG_DRUG
4018707	VANDF
C0018988	UMLSCUI
CHEBI:50385	CHEBI
CHEMBL1200662	ChEMBL_ID
CHEMBL3707238	ChEMBL_ID
DB03404	DRUGBANK_ID
D006427	MESH_DESCRIPTOR_UI
C048849	MESH_SUPPLEMENTAL_RECORD_UI
5175	RXNORM
11897	MMSL
7548	MMSL
d04360	MMSL
002038	NDDF
27345002	SNOMEDCT_US
424480005	SNOMEDCT_US
3086464	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Panhematin	HUMAN PRESCRIPTION DRUG LABEL	1	55292-702	POWDER, FOR SOLUTION	7 mg	INTRAVENOUS	BLA	25 sections
Panhematin	HUMAN PRESCRIPTION DRUG LABEL	1	55292-702	POWDER, FOR SOLUTION	7 mg	INTRAVENOUS	BLA	25 sections