beractant Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5108 108778-82-1

Description:

MoleculeDescription

Synonyms:

  • beractant
  • survanta
a bovine lung extract that contains mostly phospholipids; modified by the addition of dipalmitoylphosphatidylcholine, palmitic acid, and tripalmitin
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 1, 1991 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary haemorrhage 204.93 117.93 30 71 6475 46679486

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary haemorrhage 265.29 106.77 44 103 9348 29942983

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000079 Surfactant Activity
FDA PE N0000008294 Alveolar Surface Tension Reduction
FDA EPC N0000175778 Surfactant
MeSH PA D011663 Pulmonary Surfactants
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Respiratory distress syndrome in the newborn indication 46775006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
S866O45PIG UNII
D03096 KEGG_DRUG
4020026 VANDF
C0105750 UMLSCUI
CHEMBL1201624 ChEMBL_ID
DB06761 DRUGBANK_ID
C072197 MESH_SUPPLEMENTAL_RECORD_UI
202963 RXNORM
4268 MMSL
d00777 MMSL
003601 NDDF
387225001 SNOMEDCT_US
40905005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Survanta HUMAN PRESCRIPTION DRUG LABEL 1 0074-1040 SUSPENSION 25 mg ENDOTRACHEAL BLA 15 sections