carisoprodol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	509	78-44-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carisoprodol carisoprodate isomeprobamate isopropyl meprobamate	A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202) Molecular weight: 260.33 Formula: C12H24N2O4 CLOGP: 2.34 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 90.65 ALOGS: -2.52 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carisoprodol
carisoprodate
isomeprobamate
isopropyl meprobamate

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)

Molecular weight: 260.33
Formula: C12H24N2O4
CLOGP: 2.34
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 90.65
ALOGS: -2.52
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.40	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	76.83 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ

Approvals:

Date	Agency	Company	Orphan
April 9, 1959	FDA	MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1281.12	13.73	771	21861	131118	50451374
Respiratory arrest	585.63	13.73	280	22352	29729	50552763
Toxicity to various agents	442.37	13.73	508	22124	211991	50370501
Cardiac arrest	348.92	13.73	293	22339	83358	50499134
Cardio-respiratory arrest	233.25	13.73	193	22439	53699	50528793
Drug abuse	217.66	13.73	194	22438	59652	50522840
Poisoning	139.02	13.73	80	22552	12349	50570143
Overdose	131.89	13.73	191	22441	99536	50482956
Intentional product misuse	112.60	13.73	121	22511	46613	50535879
Drug dependence	100.81	13.73	78	22554	19681	50562811
Drug abuser	99.46	13.73	40	22592	2788	50579704
Accidental overdose	88.69	13.73	72	22560	19461	50563031
Drug withdrawal syndrome	88.49	13.73	80	22552	25001	50557491
Depression	73.23	13.73	200	22432	165223	50417269
Exposure via ingestion	72.95	13.73	32	22600	2771	50579721
Unresponsive to stimuli	71.51	13.73	78	22554	30531	50551961
Dependence	67.60	13.73	27	22605	1848	50580644
Off label use	67.26	13.73	68	22564	474358	50108134
Coma	58.38	13.73	97	22535	56782	50525710
Contraindicated product administered	54.41	13.73	3	22629	148955	50433537
Anxiety	53.67	13.73	188	22444	177418	50405074
Narcotic bowel syndrome	52.02	13.73	12	22620	118	50582374
Urinary bladder rupture	51.22	13.73	12	22620	127	50582365
Accidental death	45.67	13.73	20	22612	1724	50580768
Infusion related reaction	43.69	13.73	11	22621	169546	50412946
Drug screen positive	41.00	13.73	23	22609	3379	50579113
Drug intolerance	40.35	13.73	24	22608	219080	50363412
Insomnia	38.84	13.73	168	22464	174697	50407795
Road traffic accident	37.13	13.73	50	22582	24302	50558190
Migraine	36.26	13.73	94	22538	75186	50507306
Neutropenia	33.75	13.73	12	22620	147953	50434539
Systemic lupus erythematosus	32.77	13.73	11	22621	140611	50441881
Joint swelling	32.60	13.73	37	22595	245249	50337243
Rash	31.52	13.73	96	22536	437375	50145117
Lethargy	30.56	13.73	68	22564	49364	50533128
Wound	28.96	13.73	6	22626	105788	50476704
Alopecia	28.39	13.73	41	22591	245006	50337486
Intervertebral disc protrusion	28.28	13.73	40	22592	20353	50562139
Spinal epidural haematoma	28.05	13.73	12	22620	977	50581515
Discomfort	27.96	13.73	7	22625	108373	50474119
Purpura senile	27.68	13.73	10	22622	519	50581973
Soft tissue haemorrhage	26.94	13.73	8	22624	222	50582270
Abdominal discomfort	26.59	13.73	39	22593	231602	50350890
Emotional distress	25.62	13.73	46	22586	28617	50553875
Product use in unapproved indication	25.39	13.73	10	22622	115809	50466683
Infection	25.33	13.73	24	22608	172930	50409562
Drug ineffective	24.80	13.73	241	22391	819092	49763400
Quadriplegia	24.51	13.73	13	22619	1710	50580782
Febrile neutropenia	23.89	13.73	7	22625	97660	50484832
Tarsal tunnel syndrome	23.82	13.73	9	22623	530	50581962
Thrombocytopenia	23.46	13.73	14	22618	127659	50454833
Seizure	22.97	13.73	109	22523	117765	50464727
Pancytopenia	22.52	13.73	5	22627	84025	50498467
Injury	22.44	13.73	60	22572	48865	50533627
Feeling abnormal	22.28	13.73	113	22519	125379	50457113
Loss of consciousness	22.18	13.73	99	22533	104254	50478238
Amnesia	21.62	13.73	54	22578	42206	50540286
Peripheral swelling	21.43	13.73	37	22595	205899	50376593
Pulmonary congestion	21.28	13.73	30	22602	15217	50567275
Lower respiratory tract infection	21.23	13.73	8	22624	95193	50487299
Intervertebral disc degeneration	21.07	13.73	28	22604	13433	50569059
Product use issue	20.44	13.73	22	22610	149453	50433039
Acute kidney injury	20.25	13.73	45	22587	228013	50354479
Hepatic enzyme increased	20.18	13.73	19	22613	137361	50445131
Memory impairment	19.75	13.73	79	22553	79281	50503211
Inadequate analgesia	19.74	13.73	13	22619	2545	50579947
Intentional overdose	19.56	13.73	67	22565	62437	50520055
Chest pain	19.11	13.73	140	22492	176742	50405750
Suicidal ideation	18.78	13.73	61	22571	55324	50527168
Exposure during pregnancy	18.66	13.73	16	22616	120999	50461493
Crying	18.54	13.73	33	22599	20383	50562109
Fibromyalgia	18.49	13.73	53	22579	44925	50537567
Drowning	18.47	13.73	7	22625	416	50582076
Hyponatraemia	18.44	13.73	10	22622	96129	50486363
Resorption bone increased	18.37	13.73	9	22623	1002	50581490
Pleural adhesion	18.11	13.73	5	22627	106	50582386
Mydriasis	18.03	13.73	23	22609	10604	50571888
Blood pH decreased	17.80	13.73	12	22620	2443	50580049
Progressive multiple sclerosis	17.66	13.73	8	22624	747	50581745
Somnolence	16.92	13.73	123	22509	154862	50427630
Hyperhidrosis	16.91	13.73	82	22550	89344	50493148
Impaired driving ability	16.72	13.73	14	22618	3947	50578545
Malignant neoplasm progression	16.45	13.73	5	22627	68119	50514373
Vestibular disorder	16.44	13.73	9	22623	1260	50581232
Rheumatoid arthritis	16.36	13.73	42	22590	202508	50379984
Stomatitis	16.11	13.73	13	22619	101331	50481161
Respiratory depression	15.83	13.73	23	22609	11987	50570505
Suicide attempt	15.79	13.73	55	22577	51677	50530815
Stress	15.39	13.73	56	22576	53737	50528755
Coronary artery disease	15.22	13.73	38	22594	29688	50552804
Product complaint	15.17	13.73	22	22610	11444	50571048
Neck pain	15.16	13.73	58	22574	57009	50525483
Thinking abnormal	15.13	13.73	20	22612	9547	50572945
Hypoaesthesia	15.06	13.73	103	22529	127154	50455338
Arthropathy	14.97	13.73	30	22602	157876	50424616
Diarrhoea	14.58	13.73	181	22451	588295	49994197
Arteriosclerosis	14.39	13.73	19	22613	9058	50573434
Back pain	14.36	13.73	156	22476	219874	50362618
Renal impairment	14.32	13.73	8	22624	75653	50506839
Hyperlipidaemia	14.28	13.73	27	22605	17463	50565029
Substance abuse	14.23	13.73	13	22619	4111	50578381
Cervicobrachial syndrome	14.17	13.73	7	22625	794	50581698
C-reactive protein increased	14.14	13.73	6	22626	66468	50516024
Pyrexia	14.04	13.73	106	22526	380097	50202395
Abnormal dreams	13.91	13.73	19	22613	9358	50573134
Anaemia	13.80	13.73	62	22570	252394	50330098
Death	13.77	13.73	213	22419	325166	50257326

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory arrest	415.50	17.12	194	9939	25639	29538755
Completed suicide	366.51	17.12	278	9855	89968	29474426
Cardiac arrest	218.63	17.12	202	9931	85389	29479005
Toxicity to various agents	206.24	17.12	274	9859	173387	29391007
Drug dependence	176.19	17.12	102	10031	20879	29543515
Drug abuse	167.02	17.12	169	9964	79714	29484680
Overdose	161.66	17.12	166	9967	79653	29484741
Drug withdrawal syndrome	144.53	17.12	85	10048	17899	29546495
Drug abuser	144.51	17.12	53	10080	3774	29560620
Cardio-respiratory arrest	126.14	17.12	118	10015	50483	29513911
Accidental overdose	100.57	17.12	67	10066	17526	29546868
Poisoning	69.31	17.12	43	10090	9950	29554444
Intentional product misuse	68.01	17.12	71	10062	34590	29529804
Depression	58.93	17.12	105	10028	85042	29479352
Anxiety	54.92	17.12	102	10031	85263	29479131
Inadequate analgesia	52.24	17.12	23	10110	2631	29561763
Nervousness	43.77	17.12	34	10099	11272	29553122
Road traffic accident	40.06	17.12	37	10096	15524	29548870
Insomnia	38.24	17.12	90	10043	88671	29475723
Off label use	37.56	17.12	29	10104	300771	29263623
Drug screen positive	35.95	17.12	20	10113	3781	29560613
Hypoaesthesia	30.79	17.12	61	10072	53406	29510988
Neutropenia	29.21	17.12	5	10128	131706	29432688
Exposure via ingestion	28.81	17.12	14	10119	2004	29562390
Suicidal ideation	28.17	17.12	46	10087	34670	29529724
Back pain	27.29	17.12	87	10046	102197	29462197
Pain	26.11	17.12	122	10011	171310	29393084
Acute kidney injury	25.66	17.12	32	10101	265235	29299159
Substance abuse	25.38	17.12	20	10113	6767	29557627
Accidental death	25.25	17.12	13	10120	2105	29562289
Drug tolerance	25.05	17.12	13	10120	2140	29562254
Emotional distress	24.64	17.12	27	10106	13868	29550526
Respiratory rate decreased	23.36	17.12	12	10121	1933	29562461
Febrile neutropenia	23.31	17.12	5	10128	112235	29452159
Pyrexia	20.89	17.12	42	10091	287580	29276814
Administration related reaction	20.64	17.12	5	10128	82	29564312
Dependence	20.46	17.12	9	10124	1026	29563368
Product complaint	20.36	17.12	16	10117	5389	29559005
Kussmaul respiration	20.00	17.12	5	10128	94	29564300
Product use in unapproved indication	19.92	17.12	3	10130	86872	29477522
Amnesia	19.73	17.12	31	10102	22612	29541782
Sinus tachycardia	19.62	17.12	25	10108	15044	29549350
Back injury	19.24	17.12	13	10120	3471	29560923
Unresponsive to stimuli	18.65	17.12	32	10101	25094	29539300
Accidental poisoning	18.40	17.12	7	10126	551	29563843
Myofascial pain syndrome	18.31	17.12	6	10127	304	29564090
Somnolence	18.23	17.12	72	10061	93883	29470511
Coronary artery disease	18.12	17.12	44	10089	44146	29520248
Mental disorder due to a general medical condition	17.84	17.12	5	10128	148	29564246
Drug interaction	17.84	17.12	25	10108	197360	29367034

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1913.91	13.38	1170	25409	223244	64248909
Respiratory arrest	1044.72	13.38	485	26094	52500	64419653
Cardiac arrest	613.60	13.38	507	26072	153557	64318596
Toxicity to various agents	592.02	13.38	736	25843	362777	64109376
Cardio-respiratory arrest	406.13	13.38	331	26248	98062	64374091
Drug abuse	362.41	13.38	353	26226	132021	64340132
Overdose	347.19	13.38	376	26203	159190	64312963
Drug abuser	231.74	13.38	88	26491	5720	64466433
Intentional product misuse	211.16	13.38	200	26379	72095	64400058
Poisoning	205.07	13.38	122	26457	21757	64450396
Drug dependence	203.81	13.38	142	26437	33170	64438983
Drug withdrawal syndrome	181.24	13.38	129	26450	31162	64440991
Accidental overdose	173.15	13.38	129	26450	33428	64438725
Off label use	104.81	13.38	66	26513	632740	63839413
Depression	100.98	13.38	229	26350	183062	64289091
Exposure via ingestion	99.83	13.38	46	26533	4856	64467297
Unresponsive to stimuli	78.07	13.38	100	26479	50293	64421860
Anxiety	72.16	13.38	215	26364	202434	64269719
Accidental death	66.74	13.38	32	26547	3693	64468460
Intentional overdose	66.62	13.38	127	26452	89817	64382336
Neutropenia	63.75	13.38	11	26568	239613	64232540
Dependence	62.70	13.38	26	26553	2129	64470024
Drug screen positive	61.75	13.38	35	26544	5694	64466459
Coma	61.57	13.38	121	26458	87494	64384659
Acute kidney injury	54.50	13.38	63	26516	449177	64022976
Urinary bladder rupture	50.72	13.38	11	26568	87	64472066
Inadequate analgesia	50.29	13.38	27	26552	3951	64468202
Product use in unapproved indication	49.47	13.38	7	26572	176611	64295542
Insomnia	49.15	13.38	186	26393	197650	64274503
Road traffic accident	47.59	13.38	61	26518	30684	64441469
Drug intolerance	45.08	13.38	11	26568	187981	64284172
Febrile neutropenia	44.96	13.38	11	26568	187646	64284507
Thrombocytopenia	38.79	13.38	22	26557	223779	64248374
Emotional distress	38.67	13.38	60	26519	35978	64436175
Pyrexia	38.51	13.38	111	26468	558533	63913620
Blood pH decreased	34.72	13.38	22	26557	4380	64467773
Treatment failure	34.22	13.38	4	26575	116812	64355341
Infusion related reaction	33.37	13.38	13	26566	164454	64307699
Coronary artery disease	32.64	13.38	75	26504	60358	64411795
Substance abuse	31.55	13.38	28	26551	9264	64462889
Pancytopenia	31.34	13.38	10	26569	143299	64328854
Narcotic bowel syndrome	31.19	13.38	9	26570	245	64471908
Injury	30.80	13.38	70	26509	55922	64416231
Hypoaesthesia	30.65	13.38	126	26453	138982	64333171
Renal impairment	30.29	13.38	9	26570	135008	64337145
Synovitis	30.03	13.38	3	26576	99087	64373066
Joint swelling	29.70	13.38	27	26552	215355	64256798
Lethargy	29.65	13.38	81	26498	72513	64399640
Interstitial lung disease	29.51	13.38	3	26576	97729	64374424
Suicidal ideation	28.94	13.38	76	26503	66466	64405687
Tarsal tunnel syndrome	28.93	13.38	10	26569	495	64471658
Leukopenia	28.37	13.38	4	26575	101238	64370915
Nervousness	27.33	13.38	46	26533	29510	64442643
Intervertebral disc degeneration	26.83	13.38	30	26549	13090	64459063
Suicide attempt	26.81	13.38	77	26502	70930	64401223
Intervertebral disc protrusion	26.55	13.38	37	26542	20154	64451999
Spinal epidural haematoma	26.37	13.38	12	26567	1230	64470923
Malignant neoplasm progression	26.29	13.38	7	26572	112864	64359289
C-reactive protein increased	26.01	13.38	4	26575	94905	64377248
Cardiac failure	25.97	13.38	11	26568	132362	64339791
Sinus tachycardia	25.74	13.38	47	26532	32141	64440012
Hyperlipidaemia	25.69	13.38	39	26540	22937	64449216
General physical health deterioration	25.46	13.38	28	26551	204397	64267756
Purpura senile	25.01	13.38	9	26570	502	64471651
Infection	24.52	13.38	24	26555	184856	64287297
Sepsis	24.08	13.38	36	26543	230305	64241848
Arteriosclerosis	23.78	13.38	31	26548	15846	64456307
Drug interaction	23.42	13.38	74	26505	362009	64110144
Death	23.22	13.38	302	26277	482403	63989750
Amnesia	22.93	13.38	57	26522	48212	64423941
Condition aggravated	22.79	13.38	78	26501	372348	64099805
Anaemia	22.71	13.38	80	26499	378600	64093553
Respiratory rate decreased	22.56	13.38	17	26562	4474	64467679
Loss of consciousness	22.13	13.38	120	26459	148245	64323908
Drug ineffective	22.01	13.38	231	26348	840016	63632137
Migraine	21.78	13.38	66	26513	62611	64409542
Somnolence	21.71	13.38	151	26428	203494	64268659
Diarrhoea	21.30	13.38	193	26386	722511	63749642
Epistaxis	21.18	13.38	7	26572	98124	64374029
Pain	20.92	13.38	332	26247	553179	63918974
Pupillary reflex impaired	20.91	13.38	14	26565	3059	64469094
Pulmonary congestion	20.55	13.38	36	26543	23844	64448309
Soft tissue haemorrhage	20.30	13.38	7	26572	344	64471809
Irritability	20.27	13.38	46	26533	36700	64435453
Back pain	20.27	13.38	174	26405	249997	64222156
Rash	20.11	13.38	109	26470	458440	64013713
Drug tolerance	19.99	13.38	18	26561	6067	64466086
Hyponatraemia	19.96	13.38	19	26560	148320	64323833
Back injury	19.88	13.38	20	26559	7737	64464416
Disease progression	19.24	13.38	18	26561	141662	64330491
Chest pain	19.04	13.38	164	26415	235816	64236337
Ventricular hypertrophy	18.94	13.38	18	26561	6498	64465655
Product complaint	18.94	13.38	24	26555	11930	64460223
Neck pain	18.82	13.38	62	26517	61471	64410682
Peripheral swelling	18.81	13.38	36	26543	209117	64263036
Quadriplegia	18.78	13.38	13	26566	3000	64469153
Stomatitis	18.65	13.38	11	26568	109594	64362559
Respiratory depression	18.45	13.38	34	26545	23409	64448744
Intervertebral disc disorder	18.34	13.38	15	26564	4442	64467711
Lower respiratory tract infection	18.34	13.38	8	26571	94606	64377547
Progressive multiple sclerosis	17.88	13.38	8	26571	788	64471365
Resorption bone increased	17.84	13.38	9	26570	1159	64470994
Systemic lupus erythematosus	17.72	13.38	5	26574	77607	64394546
Administration related reaction	17.70	13.38	5	26574	126	64472027
Tremor	17.65	13.38	113	26466	148117	64324036
Product use issue	17.57	13.38	22	26557	151693	64320460
Septic shock	17.36	13.38	11	26568	105426	64366727
Wound	17.32	13.38	5	26574	76472	64395681
Feeling abnormal	17.25	13.38	104	26475	133498	64338655
Arteriosclerosis coronary artery	16.86	13.38	26	26553	15503	64456650
Platelet count decreased	16.77	13.38	27	26552	167684	64304469
Atrial fibrillation	16.68	13.38	28	26551	171061	64301092
Dyspnoea	16.65	13.38	203	26376	718471	63753682
Hyperhidrosis	16.61	13.38	98	26481	124822	64347331
Hypertensive heart disease	16.07	13.38	13	26566	3791	64468362
Accidental poisoning	15.99	13.38	9	26570	1444	64470709
Crying	15.64	13.38	29	26550	20061	64452092
White blood cell count decreased	15.23	13.38	26	26553	157811	64314342
Seizure	15.07	13.38	119	26460	166773	64305380
Depressed level of consciousness	15.05	13.38	70	26509	81366	64390787
Hepatic enzyme increased	14.88	13.38	19	26560	129924	64342229
Paranoia	14.52	13.38	25	26554	16327	64455826
Paraesthesia	14.47	13.38	100	26479	134422	64337731
Neck injury	14.44	13.38	10	26569	2308	64469845
Mydriasis	14.38	13.38	24	26555	15288	64456865
Mucosal inflammation	14.34	13.38	4	26575	62580	64409573
Gastrooesophageal reflux disease	14.30	13.38	70	26509	83073	64389080
Myofascial pain syndrome	14.22	13.38	9	26570	1789	64470364
Spinal osteoarthritis	14.17	13.38	23	26556	14318	64457835
Generalised anxiety disorder	13.70	13.38	9	26570	1906	64470247
Alopecia	13.63	13.38	30	26549	165660	64306493
Hyperkalaemia	13.55	13.38	13	26566	101116	64371037
Hypersensitivity	13.51	13.38	39	26540	196413	64275740
COVID-19	13.45	13.38	5	26574	65135	64407018

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M03BA02	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
ATC	M03BA52	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
ATC	M03BA72	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
CHEBI has role	CHEBI:51371	muscle relaxants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D018373	Peripheral Nervous System Agents
FDA PE	N0000175730	Centrally-mediated Muscle Relaxation
FDA EPC	N0000175737	Muscle Relaxant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Backache	indication	161891005
Spasticity	indication	221360009
Muscle Spasm with Pain	indication
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Lowered convulsive threshold	contraindication	19260006
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Alcohol intoxication	contraindication	25702006
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Bradycardia	contraindication	48867003
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Acute nephropathy	contraindication	58574008
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Sedation	contraindication	72641008
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Epilepsy	contraindication	84757009	DOID:1826
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hemophilia	contraindication	90935002
Anemia due to enzyme deficiency	contraindication	111577008
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
von Willebrand disorder	contraindication	128105004	DOID:12531
Acute intermittent porphyria	contraindication	234422006	DOID:3890
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Pseudomembranous enterocolitis	contraindication	397683000
Breastfeeding (mother)	contraindication	413712001
Central nervous system depression	contraindication	418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant	contraindication	424500005
Dysfunction of sphincter of Oddi	contraindication	430887001
Acute erosive gastritis	contraindication	444926003
Acute exacerbation of asthma	contraindication	708038006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018454	VUID
N0000146778	NUI
D00768	KEGG_DRUG
2101	RXNORM
C0007248	UMLSCUI
CHEBI:3419	CHEBI
CHEMBL1233	ChEMBL_ID
DB00395	DRUGBANK_ID
D002328	MESH_DESCRIPTOR_UI
2576	PUBCHEM_CID
7610	IUPHAR_LIGAND_ID
902	INN_ID
21925K482H	UNII
4359	MMSL
747	MMSL
d00960	MMSL
001672	NDDF
25076002	SNOMEDCT_US
387133006	SNOMEDCT_US
4018454	VANDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	0037-2001	TABLET	350 mg	ORAL	NDA	31 sections
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	0037-2250	TABLET	250 mg	ORAL	NDA	31 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1176	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-5513	TABLET	350 mg	ORAL	ANDA	25 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	10544-033	TABLET	350 mg	ORAL	ANDA	28 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	10544-088	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	10544-132	TABLET	350 mg	ORAL	ANDA	27 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	12634-437	TABLET	350 mg	ORAL	ANDA	32 sections
carisoprodol	Human Prescription Drug Label	1	16571-780	TABLET	250 mg	ORAL	ANDA	29 sections
carisoprodol	Human Prescription Drug Label	1	16571-781	TABLET	350 mg	ORAL	ANDA	29 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	16590-039	TABLET	350 mg	ORAL	ANDA	27 sections
SOMA	HUMAN PRESCRIPTION DRUG LABEL	1	16590-755	TABLET	250 mg	ORAL	NDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-510	TABLET	350 mg	ORAL	ANDA	32 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL WITH HIGHLIGHTS	1	21695-021	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol and Aspirin	HUMAN PRESCRIPTION DRUG LABEL	2	21695-570	TABLET	200 mg	ORAL	ANDA	19 sections
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	21695-606	TABLET	250 mg	ORAL	NDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	29033-207	TABLET	250 mg	ORAL	ANDA	30 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	29033-214	TABLET	350 mg	ORAL	ANDA	30 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	33261-387	TABLET	350 mg	ORAL	ANDA	28 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	33358-064	TABLET	350 mg	ORAL	ANDA	29 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	42543-700	TABLET	350 mg	ORAL	ANDA	30 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	42549-503	TABLET	350 mg	ORAL	ANDA	27 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	43063-824	TABLET	350 mg	ORAL	ANDA	32 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	43353-102	TABLET	350 mg	ORAL	ANDA	31 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	45865-984	TABLET	350 mg	ORAL	ANDA	30 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	49999-064	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	Human Prescription Drug Label	1	50090-0280	TABLET	350 mg	ORAL	ANDA	30 sections
Carisoprodol	Human Prescription Drug Label	1	50090-0281	TABLET	350 mg	ORAL	ANDA	30 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3048	TABLET	350 mg	ORAL	ANDA	32 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3232	TABLET	350 mg	ORAL	ANDA	33 sections