carisoprodol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
509 78-44-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carisoprodol
  • carisoprodate
  • isomeprobamate
  • isopropyl meprobamate
A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
  • Molecular weight: 260.33
  • Formula: C12H24N2O4
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 90.65
  • ALOGS: -2.52
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 76.83 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
April 9, 1959 FDA MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3218.81 63.53 649 1053 20385 2335998
Toxicity to various agents 1496.84 63.53 384 1318 32370 2324013
Respiratory arrest 1204.28 63.53 239 1463 5939 2350444
Cardiac arrest 1025.62 63.53 245 1457 14685 2341698
Cardio-respiratory arrest 665.15 63.53 158 1544 8988 2347395
Drug abuse 617.19 63.53 157 1545 11869 2344514
Poisoning 329.22 63.53 72 1630 2748 2353635
Overdose 325.13 63.53 107 1595 19800 2336583
Intentional product misuse 300.55 63.53 85 1617 9404 2346979
Coma 263.62 63.53 76 1626 8980 2347403
Death 234.81 63.53 127 1575 81341 2275042
Accidental overdose 207.83 63.53 53 1649 3919 2352464
Drug hypersensitivity 201.95 63.53 96 1606 46547 2309836
Unresponsive to stimuli 169.07 63.53 47 1655 4829 2351554
Intentional overdose 141.47 63.53 50 1652 11271 2345112
Somnolence 115.53 63.53 53 1649 23432 2332951
Exposure via ingestion 107.90 63.53 23 1679 765 2355618
Lethargy 103.06 63.53 37 1665 8693 2347690
Depressed level of consciousness 85.12 63.53 31 1671 7573 2348810
Suicide attempt 83.40 63.53 34 1668 11248 2345135
Accidental death 77.47 63.53 15 1687 304 2356079
Purpura senile 73.02 63.53 10 1692 15 2356368
Urinary bladder rupture 72.31 63.53 11 1691 46 2356337
Drug abuser 71.25 63.53 17 1685 944 2355439
Tachycardia 65.12 63.53 32 1670 16377 2340006

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1024.24 66.85 238 638 16074 1729831
Respiratory arrest 786.68 66.85 161 715 5678 1740227
Toxicity to various agents 757.24 66.85 211 665 28930 1716975
Cardiac arrest 640.78 66.85 164 712 15766 1730139
Drug abuse 514.30 66.85 134 742 13555 1732350
Cardio-respiratory arrest 386.14 66.85 99 777 9194 1736711
Overdose 324.30 66.85 98 778 16603 1729302
Accidental overdose 224.82 66.85 55 821 4109 1741796
Intentional product misuse 175.75 66.85 51 825 7307 1738598
Poisoning 165.02 66.85 39 837 2493 1743412
Death 101.63 66.85 72 804 87371 1658534
Intentional overdose 86.13 66.85 30 846 7640 1738265
Drug dependence 78.83 66.85 23 853 3304 1742601
Unresponsive to stimuli 67.26 66.85 22 854 4607 1741298

Pharmacologic Action:

SourceCodeDescription
ATC M03BA02 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA52 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA72 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
FDA PE N0000175730 Centrally-mediated Muscle Relaxation
CHEBI has role CHEBI:51371 muscle relaxant
MeSH PA D002491 Central Nervous System Agents
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Spasticity indication 221360009
Muscle Spasm with Pain indication
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Sedation contraindication 72641008
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Epilepsy contraindication 84757009 DOID:1826
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
von Willebrand disorder contraindication 128105004 DOID:12531
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Dysfunction of sphincter of Oddi contraindication 430887001
Acute erosive gastritis contraindication 444926003
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D002328 MESH_DESCRIPTOR_UI
4018454 VUID
N0000146778 NUI
C0007248 UMLSCUI
D00768 KEGG_DRUG
21925K482H UNII
902 INN_ID
25076002 SNOMEDCT_US
4018454 VANDF
001672 NDDF
747 MMSL
2101 RXNORM
387133006 SNOMEDCT_US
4359 MMSL
d00960 MMSL
CHEBI:3419 CHEBI
CHEMBL1233 ChEMBL_ID
DB00395 DRUGBANK_ID
7610 IUPHAR_LIGAND_ID
2576 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Soma HUMAN PRESCRIPTION DRUG LABEL 1 0037-2001 TABLET 350 mg ORAL NDA 17 sections
Soma HUMAN PRESCRIPTION DRUG LABEL 1 0037-2250 TABLET 250 mg ORAL NDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0143-1176 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0591-5513 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0603-2582 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 10544-033 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 10544-088 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 10544-132 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 12634-437 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 16590-039 TABLET 350 mg ORAL ANDA 18 sections
SOMA HUMAN PRESCRIPTION DRUG LABEL 1 16590-755 TABLET 250 mg ORAL NDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 16714-510 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL WITH HIGHLIGHTS 1 21695-021 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol and Aspirin HUMAN PRESCRIPTION DRUG LABEL 2 21695-570 TABLET 200 mg ORAL ANDA 12 sections
Soma HUMAN PRESCRIPTION DRUG LABEL 1 21695-606 TABLET 250 mg ORAL NDA 18 sections
Carisoprodol and Aspirin HUMAN PRESCRIPTION DRUG LABEL 2 23155-145 TABLET 200 mg ORAL ANDA 12 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 29033-207 TABLET 250 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 33261-387 TABLET 350 mg ORAL ANDA 18 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 33358-064 TABLET 350 mg ORAL ANDA 18 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42543-434 TABLET 250 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42543-700 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42549-503 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 43063-824 TABLET 350 mg ORAL ANDA 18 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 43353-102 TABLET 350 mg ORAL ANDA 18 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 45865-984 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 49999-064 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 50090-0280 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 50090-0281 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 50090-3048 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 50090-3232 TABLET 350 mg ORAL ANDA 19 sections