carisoprodol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	509	78-44-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carisoprodol carisoprodate isomeprobamate isopropyl meprobamate	A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202) Molecular weight: 260.33 Formula: C12H24N2O4 CLOGP: 2.34 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 90.65 ALOGS: -2.52 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carisoprodol
carisoprodate
isomeprobamate
isopropyl meprobamate

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)

Molecular weight: 260.33
Formula: C12H24N2O4
CLOGP: 2.34
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 90.65
ALOGS: -2.52
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.40	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	76.83 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ

Approvals:

Date	Agency	Company	Orphan
April 9, 1959	FDA	MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1394.59	13.78	786	22430	144887	63320919
Respiratory arrest	616.93	13.78	280	22936	32365	63433441
Toxicity to various agents	480.61	13.78	518	22698	246732	63219074
Cardiac arrest	376.91	13.78	294	22922	92251	63373555
Cardio-respiratory arrest	249.34	13.78	193	23023	59766	63406040
Drug abuse	229.24	13.78	199	23017	72319	63393487
Poisoning	146.78	13.78	80	23136	13620	63452186
Overdose	142.01	13.78	192	23024	114886	63350920
Intentional product misuse	111.38	13.78	124	23092	60793	63405013
Drug abuser	105.99	13.78	40	23176	2883	63462923
Drug dependence	102.08	13.78	79	23137	24404	63441402
Drug withdrawal syndrome	96.85	13.78	80	23136	27114	63438692
Accidental overdose	96.72	13.78	75	23141	23234	63442572
Off label use	81.80	13.78	76	23140	674386	62791420
Depression	81.11	13.78	204	23012	196288	63269518
Unresponsive to stimuli	78.12	13.78	78	23138	33738	63432068
Exposure via ingestion	78.01	13.78	32	23184	2877	63462929
Dependence	70.19	13.78	27	23189	2050	63463756
Coma	66.88	13.78	99	23117	64265	63401541
Contraindicated product administered	66.88	13.78	3	23213	217645	63248161
Infusion related reaction	55.82	13.78	11	23205	245510	63220296
Anxiety	55.24	13.78	190	23026	217351	63248455
Narcotic bowel syndrome	52.48	13.78	12	23204	141	63465665
Urinary bladder rupture	52.40	13.78	12	23204	142	63465664
Drug intolerance	51.88	13.78	24	23192	308637	63157169
Accidental death	47.14	13.78	20	23196	1956	63463850
Systemic lupus erythematosus	44.17	13.78	11	23205	208907	63256899
Drug screen positive	43.95	13.78	23	23193	3606	63462200
Insomnia	40.57	13.78	171	23045	215081	63250725
Wound	39.98	13.78	6	23210	163257	63302549
Joint swelling	39.49	13.78	37	23179	327629	63138177
Discomfort	36.99	13.78	8	23208	167366	63298440
Product use in unapproved indication	36.76	13.78	10	23206	179070	63286736
Alopecia	35.23	13.78	43	23173	337493	63128313
Rash	34.23	13.78	99	23117	560772	62905034
Lethargy	34.13	13.78	68	23148	55939	63409867
Abdominal discomfort	33.35	13.78	41	23175	320844	63144962
Migraine	32.30	13.78	97	23119	103249	63362557
Neutropenia	31.97	13.78	12	23204	174993	63290813
Emotional distress	30.87	13.78	48	23168	32501	63433305
Road traffic accident	30.61	13.78	51	23165	36581	63429225
Product use issue	30.14	13.78	22	23194	220498	63245308
Drug ineffective	29.97	13.78	242	22974	1044523	62421283
Intervertebral disc protrusion	29.85	13.78	40	23176	23669	63442137
Seizure	29.49	13.78	111	23105	132523	63333283
Hepatic enzyme increased	29.22	13.78	19	23197	202309	63263497
Purpura senile	29.04	13.78	10	23206	553	63465253
Spinal epidural haematoma	28.87	13.78	12	23204	1115	63464691
Loss of consciousness	27.21	13.78	100	23116	118021	63347785
Soft tissue haemorrhage	26.86	13.78	8	23208	276	63465530
Feeling abnormal	26.48	13.78	116	23100	148276	63317530
Quadriplegia	26.44	13.78	13	23203	1787	63464019
Infection	25.17	13.78	28	23188	229145	63236661
Tarsal tunnel syndrome	25.04	13.78	9	23207	565	63465241
Arthropathy	24.38	13.78	30	23186	234762	63231044
Lower respiratory tract infection	24.28	13.78	9	23207	132298	63333508
Peripheral swelling	23.62	13.78	38	23178	265904	63199902
Febrile neutropenia	23.58	13.78	7	23209	118442	63347364
Pulmonary congestion	22.87	13.78	30	23186	17388	63448418
Thrombocytopenia	22.09	13.78	14	23202	151143	63314663
Intervertebral disc degeneration	22.07	13.78	28	23188	15704	63450102
Suicidal ideation	21.82	13.78	61	23155	62360	63403446
Mydriasis	21.25	13.78	24	23192	11932	63453874
Somnolence	20.86	13.78	124	23092	178561	63287245
Intentional overdose	20.76	13.78	67	23149	74085	63391721
Pancytopenia	20.67	13.78	5	23211	96928	63368878
Exposure during pregnancy	20.62	13.78	16	23200	155531	63310275
Inadequate analgesia	20.47	13.78	13	23203	2930	63462876
Crying	20.17	13.78	33	23183	23310	63442496
Memory impairment	19.74	13.78	83	23133	104175	63361631
Blood pH decreased	19.43	13.78	12	23204	2575	63463231
Chest pain	19.21	13.78	140	23076	215819	63249987
Amnesia	19.11	13.78	54	23162	55531	63410275
Pleural adhesion	19.11	13.78	5	23211	106	63465700
Death	19.08	13.78	215	23001	374166	63091640
Drowning	18.80	13.78	7	23209	486	63465320
Stomatitis	18.73	13.78	14	23202	138711	63327095
Coronary artery disease	18.17	13.78	38	23178	32339	63433467
C-reactive protein increased	18.13	13.78	6	23210	94701	63371105
Resorption bone increased	18.12	13.78	9	23207	1265	63464541
Suicide attempt	17.92	13.78	56	23160	60862	63404944
Blister	17.66	13.78	13	23203	129801	63336005
Impaired driving ability	17.59	13.78	14	23202	4497	63461309
Helicobacter infection	17.55	13.78	6	23210	92779	63373027
Hyperhidrosis	17.51	13.78	82	23134	107754	63358052
Vestibular disorder	17.13	13.78	9	23207	1422	63464384
Respiratory depression	17.05	13.78	23	23193	13692	63452114
Back pain	16.93	13.78	159	23057	263986	63201820
Hyponatraemia	16.85	13.78	10	23206	111890	63353916
Rheumatoid arthritis	16.78	13.78	43	23173	253776	63212030
Product complaint	16.72	13.78	22	23194	12787	63453019
Thinking abnormal	16.64	13.78	20	23196	10623	63455183
Neck pain	16.22	13.78	59	23157	69259	63396547
Mental status changes	16.17	13.78	41	23175	39558	63426248
Malignant neoplasm progression	16.08	13.78	5	23211	82116	63383690
Hyperlipidaemia	16.02	13.78	27	23189	19544	63446262
Arteriosclerosis	15.87	13.78	19	23197	10047	63455759
Therapeutic product effect decreased	15.86	13.78	29	23187	193158	63272648
Progressive multiple sclerosis	15.81	13.78	8	23208	1170	63464636
Tremor	15.57	13.78	92	23124	132147	63333659
Hypersensitivity	15.47	13.78	55	23161	292630	63173176
Nasopharyngitis	15.37	13.78	45	23171	254212	63211594
Irritability	15.29	13.78	35	23181	31659	63434147
Abnormal dreams	15.20	13.78	19	23197	10497	63455309
Injury	15.20	13.78	60	23156	73187	63392619
Therapeutic product effect incomplete	15.18	13.78	14	23202	125042	63340764
General physical health deterioration	15.01	13.78	32	23184	201370	63264436
Condition aggravated	15.01	13.78	86	23130	402131	63063675
Acute kidney injury	14.94	13.78	48	23168	263367	63202439
Suspected suicide	14.88	13.78	15	23201	6553	63459253
Substance abuse	14.77	13.78	13	23203	4794	63461012
Stress	14.74	13.78	56	23160	67111	63398695
Disease progression	14.60	13.78	14	23202	122744	63343062
Pneumonia aspiration	14.35	13.78	36	23180	34504	63431302
Withdrawal syndrome	14.30	13.78	26	23190	19971	63445835
Ill-defined disorder	14.27	13.78	6	23210	81749	63384057
Cervicobrachial syndrome	14.19	13.78	7	23209	970	63464836
Pupillary reflex impaired	14.13	13.78	9	23207	2038	63463768
Musculoskeletal stiffness	14.04	13.78	29	23187	184589	63281217

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory arrest	427.61	17.23	194	10140	27849	34918748
Completed suicide	393.69	17.23	283	10051	97885	34848712
Toxicity to various agents	242.22	17.23	296	10038	200066	34746531
Cardiac arrest	224.01	17.23	202	10132	95957	34850640
Overdose	178.70	17.23	174	10160	90885	34855712
Drug dependence	176.57	17.23	102	10232	24115	34922482
Drug abuse	160.96	17.23	171	10163	98925	34847672
Drug abuser	150.45	17.23	53	10281	3901	34942696
Drug withdrawal syndrome	148.45	17.23	85	10249	19749	34926848
Cardio-respiratory arrest	132.14	17.23	118	10216	55155	34891442
Accidental overdose	116.14	17.23	73	10261	20067	34926530
Poisoning	67.17	17.23	43	10291	12183	34934414
Intentional product misuse	63.95	17.23	73	10261	45538	34901059
Depression	61.47	17.23	106	10228	96992	34849605
Anxiety	54.56	17.23	102	10232	99326	34847271
Inadequate analgesia	52.97	17.23	23	10311	2952	34943645
Off label use	46.42	17.23	34	10300	419490	34527107
Nervousness	44.94	17.23	34	10300	12572	34934025
Road traffic accident	41.11	17.23	37	10297	17413	34929184
Drug screen positive	38.03	17.23	20	10314	3923	34942674
Insomnia	37.64	17.23	90	10244	103817	34842780
Suicidal ideation	36.53	17.23	52	10282	40336	34906261
Hypoaesthesia	31.15	17.23	61	10273	61383	34885214
Neutropenia	30.30	17.23	5	10329	156773	34789824
Exposure via ingestion	29.75	17.23	14	10320	2167	34944430
Back pain	28.60	17.23	90	10244	121699	34824898
Emotional distress	26.19	17.23	27	10307	14999	34931598
Substance abuse	25.89	17.23	20	10314	7621	34938976
Accidental death	25.24	17.23	13	10321	2443	34944154
Acute kidney injury	25.18	17.23	32	10302	304956	34641641
Febrile neutropenia	25.06	17.23	5	10329	136844	34809753
Product use in unapproved indication	24.44	17.23	3	10331	117496	34829101
Pain	24.25	17.23	122	10212	204553	34742044
Drug tolerance	23.29	17.23	13	10321	2869	34943728
Respiratory rate decreased	22.85	17.23	12	10322	2347	34944250
Product complaint	21.24	17.23	16	10318	5874	34940723
Coronary artery disease	20.98	17.23	45	10289	48260	34898337
Dependence	20.83	17.23	9	10325	1141	34945456
Pyrexia	20.82	17.23	42	10292	332971	34613626
Administration related reaction	20.54	17.23	5	10329	98	34946499
Kussmaul respiration	20.40	17.23	5	10329	101	34946496
Unresponsive to stimuli	19.95	17.23	32	10302	27537	34919060
Sinus tachycardia	19.74	17.23	25	10309	17335	34929262
Amnesia	19.45	17.23	31	10303	26532	34920065
Back injury	19.23	17.23	13	10321	4028	34942569
Mental disorder due to a general medical condition	18.54	17.23	5	10329	149	34946448
Myofascial pain syndrome	18.03	17.23	6	10328	371	34946226
Ventricular hypertrophy	17.70	17.23	13	10321	4594	34942003
Intervertebral disc protrusion	17.55	17.23	18	10316	9938	34936659
Blood pH decreased	17.43	17.23	10	10324	2324	34944273
Somnolence	17.43	17.23	72	10262	111044	34835553

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	2075.82	13.25	1190	25959	244577	79472662
Respiratory arrest	1094.96	13.25	485	26664	57065	79660174
Toxicity to various agents	667.61	13.25	766	26383	420774	79296465
Cardiac arrest	651.58	13.25	508	26641	171588	79545651
Cardio-respiratory arrest	433.35	13.25	331	26818	108179	79609060
Overdose	378.29	13.25	385	26764	183821	79533418
Drug abuse	369.05	13.25	359	26790	162332	79554907
Drug abuser	245.14	13.25	88	27061	5925	79711314
Poisoning	210.36	13.25	122	27027	25150	79692089
Intentional product misuse	206.15	13.25	205	26944	94960	79622279
Drug dependence	204.72	13.25	143	27006	40626	79676613
Accidental overdose	194.48	13.25	137	27012	39444	79677795
Drug withdrawal syndrome	191.39	13.25	129	27020	34589	79682650
Off label use	128.72	13.25	75	27074	907140	78810099
Depression	107.98	13.25	232	26917	216558	79500681
Exposure via ingestion	105.87	13.25	46	27103	5128	79712111
Unresponsive to stimuli	85.22	13.25	100	27049	55688	79661551
Intentional overdose	75.48	13.25	132	27017	105828	79611411
Anxiety	72.32	13.25	217	26932	248295	79468944
Coma	68.61	13.25	123	27026	100526	79616713
Accidental death	68.25	13.25	32	27117	4259	79712980
Drug screen positive	66.16	13.25	35	27114	6028	79711211
Dependence	64.56	13.25	26	27123	2396	79714843
Neutropenia	63.04	13.25	11	27138	287699	79429540
Product use in unapproved indication	60.85	13.25	7	27142	250352	79466887
Drug intolerance	55.92	13.25	11	27138	264108	79453131
Inadequate analgesia	51.29	13.25	27	27122	4602	79712637
Urinary bladder rupture	50.78	13.25	11	27138	107	79717132
Insomnia	48.32	13.25	188	26961	244982	79472257
Acute kidney injury	47.01	13.25	65	27084	519339	79197900
Febrile neutropenia	46.09	13.25	11	27138	230988	79486251
Emotional distress	45.68	13.25	62	27087	39907	79677332
Road traffic accident	41.45	13.25	62	27087	43602	79673637
Treatment failure	40.84	13.25	5	27144	170481	79546758
Infusion related reaction	40.35	13.25	14	27135	230223	79487016
Synovitis	39.84	13.25	3	27146	150731	79566508
Coronary artery disease	39.56	13.25	76	27073	65398	79651841
Suicidal ideation	38.27	13.25	82	27067	76258	79640981
Thrombocytopenia	37.33	13.25	22	27127	265237	79452002
Blood pH decreased	37.22	13.25	22	27127	4689	79712550
Pyrexia	36.78	13.25	114	27035	678595	79038644
Joint swelling	36.48	13.25	27	27122	288619	79428620
Lethargy	33.71	13.25	81	27068	81211	79636028
Substance abuse	33.16	13.25	28	27121	10498	79706741
Narcotic bowel syndrome	32.03	13.25	9	27140	271	79716968
General physical health deterioration	31.96	13.25	28	27121	275210	79442029
C-reactive protein increased	30.37	13.25	4	27145	129023	79588216
Tarsal tunnel syndrome	30.22	13.25	10	27139	526	79716713
Nervousness	29.67	13.25	46	27103	33369	79683870
Suicide attempt	29.54	13.25	78	27071	82854	79634385
Pancytopenia	29.16	13.25	10	27139	165735	79551504
Drug ineffective	28.85	13.25	233	26916	1080680	78636559
Condition aggravated	28.68	13.25	82	27067	501042	79216197
Loss of consciousness	28.48	13.25	123	27026	167820	79549419
Death	28.35	13.25	306	26843	566208	79151031
Hypoaesthesia	27.88	13.25	128	27021	179224	79538015
Interstitial lung disease	27.71	13.25	3	27146	112597	79604642
Hyperlipidaemia	27.60	13.25	39	27110	26054	79691185
Sinus tachycardia	27.59	13.25	47	27102	36861	79680378
Intervertebral disc protrusion	27.53	13.25	37	27112	23584	79693655
Intervertebral disc degeneration	26.97	13.25	30	27119	15755	79701484
Renal impairment	26.94	13.25	10	27139	157773	79559466
Spinal epidural haematoma	26.93	13.25	12	27137	1420	79715819
Arteriosclerosis	26.71	13.25	32	27117	18195	79699044
Leukopenia	26.51	13.25	4	27145	116509	79600730
Purpura senile	26.37	13.25	9	27140	521	79716718
Malignant neoplasm progression	26.10	13.25	7	27142	135983	79581256
Systemic lupus erythematosus	25.72	13.25	5	27144	121144	79596095
Infection	25.26	13.25	27	27122	241685	79475554
Injury	24.72	13.25	70	27079	77426	79639813
Cardiac failure	24.51	13.25	11	27138	154831	79562408
Somnolence	24.45	13.25	152	26997	238829	79478410
COVID-19	23.74	13.25	12	27137	157662	79559577
Product use issue	23.57	13.25	22	27127	209800	79507439
Respiratory rate decreased	23.10	13.25	17	27132	5226	79712013
Irritability	22.72	13.25	46	27103	41098	79676141
Tremor	22.56	13.25	116	27033	169967	79547272
Lower respiratory tract infection	22.38	13.25	8	27141	129212	79588027
Disease progression	22.32	13.25	18	27131	184344	79532895
Wound	22.26	13.25	6	27143	116173	79601066
Pulmonary congestion	22.25	13.25	36	27113	27064	79690175
Pupillary reflex impaired	22.24	13.25	14	27135	3339	79713900
Peripheral swelling	22.15	13.25	36	27113	269581	79447658
Back pain	22.07	13.25	178	26971	304002	79413237
Rash	21.84	13.25	112	27037	578246	79138993
Ventricular hypertrophy	20.92	13.25	18	27131	6920	79710319
Stomatitis	20.87	13.25	12	27137	146745	79570494
Hepatic enzyme increased	20.68	13.25	19	27130	182591	79534648
Product complaint	20.49	13.25	24	27125	13325	79703914
Soft tissue haemorrhage	20.33	13.25	7	27142	416	79716823
Sepsis	20.29	13.25	38	27111	269390	79447849
Amnesia	20.15	13.25	57	27092	63000	79654239
Anaemia	19.88	13.25	81	27068	444934	79272305
Seizure	19.87	13.25	121	27028	188713	79528526
Chest pain	19.83	13.25	164	26985	282140	79435099
Intervertebral disc disorder	19.82	13.25	15	27134	4810	79712429
Discomfort	19.76	13.25	9	27140	125608	79591631
Quadriplegia	19.74	13.25	13	27136	3347	79713892
Hyponatraemia	19.56	13.25	19	27130	177829	79539410
Diarrhoea	19.42	13.25	199	26950	880290	78836949
Feeling abnormal	19.35	13.25	106	27043	159093	79558146
Neck pain	19.25	13.25	63	27086	75354	79641885
Epistaxis	19.15	13.25	7	27142	111508	79605731
Pain	19.13	13.25	341	26808	703461	79013778
Respiratory depression	19.11	13.25	34	27115	27596	79689643
Alopecia	18.90	13.25	31	27118	231324	79485915
Drug interaction	18.90	13.25	75	27074	415108	79302131
Migraine	18.78	13.25	69	27080	87424	79629815
Hypersensitivity	18.03	13.25	39	27110	262200	79455039
Back injury	17.98	13.25	20	27129	10503	79706736
Arteriosclerosis coronary artery	17.92	13.25	26	27123	17790	79699449
Drug tolerance	17.49	13.25	18	27131	8657	79708582
Resorption bone increased	17.48	13.25	9	27140	1466	79715773
Hypertensive heart disease	17.11	13.25	13	27136	4193	79713046
Therapeutic product effect incomplete	16.93	13.25	14	27135	141631	79575608
Crying	16.77	13.25	29	27120	23014	79694225
Mydriasis	16.66	13.25	25	27124	17618	79699621
Hyperhidrosis	16.52	13.25	98	27051	151394	79565845
Accidental poisoning	16.49	13.25	9	27140	1648	79715591
Suspected suicide	16.21	13.25	19	27130	10557	79706682
Septic shock	16.14	13.25	11	27138	122790	79594449
Progressive multiple sclerosis	16.10	13.25	8	27141	1209	79716030
Depressed level of consciousness	15.77	13.25	70	27079	96582	79620657
Nasopharyngitis	15.65	13.25	40	27109	253841	79463398
Administration related reaction	15.63	13.25	5	27144	236	79717003
Abdominal discomfort	15.08	13.25	40	27109	250687	79466552
Paranoia	14.86	13.25	25	27124	19407	79697832
Myofascial pain syndrome	14.76	13.25	9	27140	2028	79715211
Spinal osteoarthritis	14.60	13.25	23	27126	16904	79700335
Myocardial infarction	14.58	13.25	110	27039	184019	79533220
Dyspnoea	14.56	13.25	205	26944	856820	78860419
Neck injury	14.52	13.25	10	27139	2771	79714468
Mucosal inflammation	14.29	13.25	4	27145	75576	79641663
Dysarthria	14.23	13.25	53	27096	67569	79649670
Platelet count decreased	14.18	13.25	28	27121	194636	79522603
Drug tolerance increased	14.14	13.25	6	27143	631	79716608
Generalised anxiety disorder	14.14	13.25	9	27140	2188	79715051
Atrial fibrillation	13.95	13.25	29	27120	197857	79519382
White blood cell count decreased	13.78	13.25	27	27122	188261	79528978
Gastrooesophageal reflux disease	13.75	13.25	71	27078	104175	79613064
Mental status changes	13.69	13.25	52	27097	66907	79650332
Rheumatoid arthritis	13.51	13.25	32	27117	208438	79508801
Memory impairment	13.31	13.25	74	27075	111660	79605579

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M03BA02	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
ATC	M03BA52	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
ATC	M03BA72	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
CHEBI has role	CHEBI:51371	muscle relaxants
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D018373	Peripheral Nervous System Agents
FDA PE	N0000175730	Centrally-mediated Muscle Relaxation
FDA EPC	N0000175737	Muscle Relaxant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Backache	indication	161891005
Spasticity	indication	221360009
Muscle Spasm with Pain	indication
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Lowered convulsive threshold	contraindication	19260006
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Alcohol intoxication	contraindication	25702006
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Bradycardia	contraindication	48867003
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Acute nephropathy	contraindication	58574008
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Sedation	contraindication	72641008
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Epilepsy	contraindication	84757009	DOID:1826
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hemophilia	contraindication	90935002
Anemia due to enzyme deficiency	contraindication	111577008
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
von Willebrand disorder	contraindication	128105004	DOID:12531
Acute intermittent porphyria	contraindication	234422006	DOID:3890
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Pseudomembranous enterocolitis	contraindication	397683000
Breastfeeding (mother)	contraindication	413712001
Central nervous system depression	contraindication	418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant	contraindication	424500005
Dysfunction of sphincter of Oddi	contraindication	430887001
Acute erosive gastritis	contraindication	444926003
Acute exacerbation of asthma	contraindication	708038006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018454	VUID
N0000146778	NUI
D00768	KEGG_DRUG
2101	RXNORM
C0007248	UMLSCUI
CHEBI:3419	CHEBI
CHEMBL1233	ChEMBL_ID
DB00395	DRUGBANK_ID
D002328	MESH_DESCRIPTOR_UI
2576	PUBCHEM_CID
7610	IUPHAR_LIGAND_ID
902	INN_ID
21925K482H	UNII
4359	MMSL
747	MMSL
d00960	MMSL
25076002	SNOMEDCT_US
387133006	SNOMEDCT_US
4018454	VANDF
001672	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	0037-2001	TABLET	350 mg	ORAL	NDA	31 sections
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	0037-2001	TABLET	350 mg	ORAL	NDA	31 sections
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	0037-2250	TABLET	250 mg	ORAL	NDA	31 sections
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	0037-2250	TABLET	250 mg	ORAL	NDA	31 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1176	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-5513	TABLET	350 mg	ORAL	ANDA	25 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-5513	TABLET	350 mg	ORAL	ANDA	25 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	10544-033	TABLET	350 mg	ORAL	ANDA	28 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	10544-088	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	10544-132	TABLET	350 mg	ORAL	ANDA	27 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	12634-437	TABLET	350 mg	ORAL	ANDA	32 sections
carisoprodol	Human Prescription Drug Label	1	16571-780	TABLET	250 mg	ORAL	ANDA	29 sections
carisoprodol	Human Prescription Drug Label	1	16571-781	TABLET	350 mg	ORAL	ANDA	29 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	16590-039	TABLET	350 mg	ORAL	ANDA	27 sections
SOMA	HUMAN PRESCRIPTION DRUG LABEL	1	16590-755	TABLET	250 mg	ORAL	NDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-510	TABLET	350 mg	ORAL	ANDA	32 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	16714-510	TABLET	350 mg	ORAL	ANDA	32 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL WITH HIGHLIGHTS	1	21695-021	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol and Aspirin	HUMAN PRESCRIPTION DRUG LABEL	2	21695-570	TABLET	200 mg	ORAL	ANDA	19 sections
Soma	HUMAN PRESCRIPTION DRUG LABEL	1	21695-606	TABLET	250 mg	ORAL	NDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	29033-207	TABLET	250 mg	ORAL	ANDA	30 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	29033-214	TABLET	350 mg	ORAL	ANDA	30 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	33261-387	TABLET	350 mg	ORAL	ANDA	28 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	33358-064	TABLET	350 mg	ORAL	ANDA	29 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	42543-700	TABLET	350 mg	ORAL	ANDA	30 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	42549-503	TABLET	350 mg	ORAL	ANDA	27 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	43063-824	TABLET	350 mg	ORAL	ANDA	32 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	43063-824	TABLET	350 mg	ORAL	ANDA	32 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	43353-102	TABLET	350 mg	ORAL	ANDA	31 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	45865-984	TABLET	350 mg	ORAL	ANDA	30 sections