carisoprodol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	509	78-44-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carisoprodol carisoprodate isomeprobamate isopropyl meprobamate	A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202) Molecular weight: 260.33 Formula: C12H24N2O4 CLOGP: 2.34 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 90.65 ALOGS: -2.52 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carisoprodol
carisoprodate
isomeprobamate
isopropyl meprobamate

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)

Molecular weight: 260.33
Formula: C12H24N2O4
CLOGP: 2.34
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 90.65
ALOGS: -2.52
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.40	g	O

ADMET properties:

Show entries

Search:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	76.83 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ

Showing 1 to 2 of 2 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
April 9, 1959	FDA	MEDA PHARMS

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1394.59	13.78	786	22430	144887	63320919
Respiratory arrest	616.93	13.78	280	22936	32365	63433441
Toxicity to various agents	480.61	13.78	518	22698	246732	63219074
Cardiac arrest	376.91	13.78	294	22922	92251	63373555
Cardio-respiratory arrest	249.34	13.78	193	23023	59766	63406040
Drug abuse	229.24	13.78	199	23017	72319	63393487
Poisoning	146.78	13.78	80	23136	13620	63452186
Overdose	142.01	13.78	192	23024	114886	63350920
Intentional product misuse	111.38	13.78	124	23092	60793	63405013
Drug abuser	105.99	13.78	40	23176	2883	63462923

Showing 1 to 10 of 119 entries

Previous1 2 3 4 5…12Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory arrest	427.61	17.23	194	10140	27849	34918748
Completed suicide	393.69	17.23	283	10051	97885	34848712
Toxicity to various agents	242.22	17.23	296	10038	200066	34746531
Cardiac arrest	224.01	17.23	202	10132	95957	34850640
Overdose	178.70	17.23	174	10160	90885	34855712
Drug dependence	176.57	17.23	102	10232	24115	34922482
Drug abuse	160.96	17.23	171	10163	98925	34847672
Drug abuser	150.45	17.23	53	10281	3901	34942696
Drug withdrawal syndrome	148.45	17.23	85	10249	19749	34926848
Cardio-respiratory arrest	132.14	17.23	118	10216	55155	34891442

Showing 1 to 10 of 51 entries

Previous1 2 3 4 5 6Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	2075.82	13.25	1190	25959	244577	79472662
Respiratory arrest	1094.96	13.25	485	26664	57065	79660174
Toxicity to various agents	667.61	13.25	766	26383	420774	79296465
Cardiac arrest	651.58	13.25	508	26641	171588	79545651
Cardio-respiratory arrest	433.35	13.25	331	26818	108179	79609060
Overdose	378.29	13.25	385	26764	183821	79533418
Drug abuse	369.05	13.25	359	26790	162332	79554907
Drug abuser	245.14	13.25	88	27061	5925	79711314
Poisoning	210.36	13.25	122	27027	25150	79692089
Intentional product misuse	206.15	13.25	205	26944	94960	79622279

Showing 1 to 10 of 143 entries

Previous1 2 3 4 5…15Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	M03BA02	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
ATC	M03BA52	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
ATC	M03BA72	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Carbamic acid esters
CHEBI has role	CHEBI:51371	muscle relaxants
FDA EPC	N0000175737	Muscle Relaxant
FDA PE	N0000175730	Centrally-mediated Muscle Relaxation
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D018373	Peripheral Nervous System Agents

Showing 1 to 10 of 10 entries

Previous1Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Backache	indication	161891005
Spasticity	indication	221360009
Muscle Spasm with Pain	indication
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Lowered convulsive threshold	contraindication	19260006
Inflammatory bowel disease	contraindication	24526004	DOID:0050589

Showing 1 to 10 of 56 entries

Previous1 2 3 4 5 6Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

Show entries

Search:

ID	Source
001672	NDDF
2101	RXNORM
21925K482H	UNII
25076002	SNOMEDCT_US
2576	PUBCHEM_CID
387133006	SNOMEDCT_US
4018454	VUID
4018454	VANDF
4359	MMSL
747	MMSL

Showing 1 to 10 of 20 entries

Previous1 2Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-1176	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-5513	TABLET	350 mg	ORAL	ANDA	25 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	0591-5513	TABLET	350 mg	ORAL	ANDA	25 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	10544-033	TABLET	350 mg	ORAL	ANDA	28 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	10544-088	TABLET	350 mg	ORAL	ANDA	29 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	10544-132	TABLET	350 mg	ORAL	ANDA	27 sections
Carisoprodol	HUMAN PRESCRIPTION DRUG LABEL	1	12634-437	TABLET	350 mg	ORAL	ANDA	32 sections
carisoprodol	Human Prescription Drug Label	1	16571-780	TABLET	250 mg	ORAL	ANDA	29 sections
carisoprodol	Human Prescription Drug Label	1	16571-781	TABLET	350 mg	ORAL	ANDA	29 sections
CARISOPRODOL	HUMAN PRESCRIPTION DRUG LABEL	1	16590-039	TABLET	350 mg	ORAL	ANDA	27 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next