carisoprodol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
509 78-44-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carisoprodol
  • carisoprodate
  • isomeprobamate
  • isopropyl meprobamate
A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
  • Molecular weight: 260.33
  • Formula: C12H24N2O4
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 90.65
  • ALOGS: -2.52
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.40 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 76.83 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
April 9, 1959 FDA MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1281.12 13.73 771 21861 131118 50451374
Respiratory arrest 585.63 13.73 280 22352 29729 50552763
Toxicity to various agents 442.37 13.73 508 22124 211991 50370501
Cardiac arrest 348.92 13.73 293 22339 83358 50499134
Cardio-respiratory arrest 233.25 13.73 193 22439 53699 50528793
Drug abuse 217.66 13.73 194 22438 59652 50522840
Poisoning 139.02 13.73 80 22552 12349 50570143
Overdose 131.89 13.73 191 22441 99536 50482956
Intentional product misuse 112.60 13.73 121 22511 46613 50535879
Drug dependence 100.81 13.73 78 22554 19681 50562811
Drug abuser 99.46 13.73 40 22592 2788 50579704
Accidental overdose 88.69 13.73 72 22560 19461 50563031
Drug withdrawal syndrome 88.49 13.73 80 22552 25001 50557491
Depression 73.23 13.73 200 22432 165223 50417269
Exposure via ingestion 72.95 13.73 32 22600 2771 50579721
Unresponsive to stimuli 71.51 13.73 78 22554 30531 50551961
Dependence 67.60 13.73 27 22605 1848 50580644
Off label use 67.26 13.73 68 22564 474358 50108134
Coma 58.38 13.73 97 22535 56782 50525710
Contraindicated product administered 54.41 13.73 3 22629 148955 50433537
Anxiety 53.67 13.73 188 22444 177418 50405074
Narcotic bowel syndrome 52.02 13.73 12 22620 118 50582374
Urinary bladder rupture 51.22 13.73 12 22620 127 50582365
Accidental death 45.67 13.73 20 22612 1724 50580768
Infusion related reaction 43.69 13.73 11 22621 169546 50412946
Drug screen positive 41.00 13.73 23 22609 3379 50579113
Drug intolerance 40.35 13.73 24 22608 219080 50363412
Insomnia 38.84 13.73 168 22464 174697 50407795
Road traffic accident 37.13 13.73 50 22582 24302 50558190
Migraine 36.26 13.73 94 22538 75186 50507306
Neutropenia 33.75 13.73 12 22620 147953 50434539
Systemic lupus erythematosus 32.77 13.73 11 22621 140611 50441881
Joint swelling 32.60 13.73 37 22595 245249 50337243
Rash 31.52 13.73 96 22536 437375 50145117
Lethargy 30.56 13.73 68 22564 49364 50533128
Wound 28.96 13.73 6 22626 105788 50476704
Alopecia 28.39 13.73 41 22591 245006 50337486
Intervertebral disc protrusion 28.28 13.73 40 22592 20353 50562139
Spinal epidural haematoma 28.05 13.73 12 22620 977 50581515
Discomfort 27.96 13.73 7 22625 108373 50474119
Purpura senile 27.68 13.73 10 22622 519 50581973
Soft tissue haemorrhage 26.94 13.73 8 22624 222 50582270
Abdominal discomfort 26.59 13.73 39 22593 231602 50350890
Emotional distress 25.62 13.73 46 22586 28617 50553875
Product use in unapproved indication 25.39 13.73 10 22622 115809 50466683
Infection 25.33 13.73 24 22608 172930 50409562
Drug ineffective 24.80 13.73 241 22391 819092 49763400
Quadriplegia 24.51 13.73 13 22619 1710 50580782
Febrile neutropenia 23.89 13.73 7 22625 97660 50484832
Tarsal tunnel syndrome 23.82 13.73 9 22623 530 50581962
Thrombocytopenia 23.46 13.73 14 22618 127659 50454833
Seizure 22.97 13.73 109 22523 117765 50464727
Pancytopenia 22.52 13.73 5 22627 84025 50498467
Injury 22.44 13.73 60 22572 48865 50533627
Feeling abnormal 22.28 13.73 113 22519 125379 50457113
Loss of consciousness 22.18 13.73 99 22533 104254 50478238
Amnesia 21.62 13.73 54 22578 42206 50540286
Peripheral swelling 21.43 13.73 37 22595 205899 50376593
Pulmonary congestion 21.28 13.73 30 22602 15217 50567275
Lower respiratory tract infection 21.23 13.73 8 22624 95193 50487299
Intervertebral disc degeneration 21.07 13.73 28 22604 13433 50569059
Product use issue 20.44 13.73 22 22610 149453 50433039
Acute kidney injury 20.25 13.73 45 22587 228013 50354479
Hepatic enzyme increased 20.18 13.73 19 22613 137361 50445131
Memory impairment 19.75 13.73 79 22553 79281 50503211
Inadequate analgesia 19.74 13.73 13 22619 2545 50579947
Intentional overdose 19.56 13.73 67 22565 62437 50520055
Chest pain 19.11 13.73 140 22492 176742 50405750
Suicidal ideation 18.78 13.73 61 22571 55324 50527168
Exposure during pregnancy 18.66 13.73 16 22616 120999 50461493
Crying 18.54 13.73 33 22599 20383 50562109
Fibromyalgia 18.49 13.73 53 22579 44925 50537567
Drowning 18.47 13.73 7 22625 416 50582076
Hyponatraemia 18.44 13.73 10 22622 96129 50486363
Resorption bone increased 18.37 13.73 9 22623 1002 50581490
Pleural adhesion 18.11 13.73 5 22627 106 50582386
Mydriasis 18.03 13.73 23 22609 10604 50571888
Blood pH decreased 17.80 13.73 12 22620 2443 50580049
Progressive multiple sclerosis 17.66 13.73 8 22624 747 50581745
Somnolence 16.92 13.73 123 22509 154862 50427630
Hyperhidrosis 16.91 13.73 82 22550 89344 50493148
Impaired driving ability 16.72 13.73 14 22618 3947 50578545
Malignant neoplasm progression 16.45 13.73 5 22627 68119 50514373
Vestibular disorder 16.44 13.73 9 22623 1260 50581232
Rheumatoid arthritis 16.36 13.73 42 22590 202508 50379984
Stomatitis 16.11 13.73 13 22619 101331 50481161
Respiratory depression 15.83 13.73 23 22609 11987 50570505
Suicide attempt 15.79 13.73 55 22577 51677 50530815
Stress 15.39 13.73 56 22576 53737 50528755
Coronary artery disease 15.22 13.73 38 22594 29688 50552804
Product complaint 15.17 13.73 22 22610 11444 50571048
Neck pain 15.16 13.73 58 22574 57009 50525483
Thinking abnormal 15.13 13.73 20 22612 9547 50572945
Hypoaesthesia 15.06 13.73 103 22529 127154 50455338
Arthropathy 14.97 13.73 30 22602 157876 50424616
Diarrhoea 14.58 13.73 181 22451 588295 49994197
Arteriosclerosis 14.39 13.73 19 22613 9058 50573434
Back pain 14.36 13.73 156 22476 219874 50362618
Renal impairment 14.32 13.73 8 22624 75653 50506839
Hyperlipidaemia 14.28 13.73 27 22605 17463 50565029
Substance abuse 14.23 13.73 13 22619 4111 50578381
Cervicobrachial syndrome 14.17 13.73 7 22625 794 50581698
C-reactive protein increased 14.14 13.73 6 22626 66468 50516024
Pyrexia 14.04 13.73 106 22526 380097 50202395
Abnormal dreams 13.91 13.73 19 22613 9358 50573134
Anaemia 13.80 13.73 62 22570 252394 50330098
Death 13.77 13.73 213 22419 325166 50257326

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory arrest 415.50 17.12 194 9939 25639 29538755
Completed suicide 366.51 17.12 278 9855 89968 29474426
Cardiac arrest 218.63 17.12 202 9931 85389 29479005
Toxicity to various agents 206.24 17.12 274 9859 173387 29391007
Drug dependence 176.19 17.12 102 10031 20879 29543515
Drug abuse 167.02 17.12 169 9964 79714 29484680
Overdose 161.66 17.12 166 9967 79653 29484741
Drug withdrawal syndrome 144.53 17.12 85 10048 17899 29546495
Drug abuser 144.51 17.12 53 10080 3774 29560620
Cardio-respiratory arrest 126.14 17.12 118 10015 50483 29513911
Accidental overdose 100.57 17.12 67 10066 17526 29546868
Poisoning 69.31 17.12 43 10090 9950 29554444
Intentional product misuse 68.01 17.12 71 10062 34590 29529804
Depression 58.93 17.12 105 10028 85042 29479352
Anxiety 54.92 17.12 102 10031 85263 29479131
Inadequate analgesia 52.24 17.12 23 10110 2631 29561763
Nervousness 43.77 17.12 34 10099 11272 29553122
Road traffic accident 40.06 17.12 37 10096 15524 29548870
Insomnia 38.24 17.12 90 10043 88671 29475723
Off label use 37.56 17.12 29 10104 300771 29263623
Drug screen positive 35.95 17.12 20 10113 3781 29560613
Hypoaesthesia 30.79 17.12 61 10072 53406 29510988
Neutropenia 29.21 17.12 5 10128 131706 29432688
Exposure via ingestion 28.81 17.12 14 10119 2004 29562390
Suicidal ideation 28.17 17.12 46 10087 34670 29529724
Back pain 27.29 17.12 87 10046 102197 29462197
Pain 26.11 17.12 122 10011 171310 29393084
Acute kidney injury 25.66 17.12 32 10101 265235 29299159
Substance abuse 25.38 17.12 20 10113 6767 29557627
Accidental death 25.25 17.12 13 10120 2105 29562289
Drug tolerance 25.05 17.12 13 10120 2140 29562254
Emotional distress 24.64 17.12 27 10106 13868 29550526
Respiratory rate decreased 23.36 17.12 12 10121 1933 29562461
Febrile neutropenia 23.31 17.12 5 10128 112235 29452159
Pyrexia 20.89 17.12 42 10091 287580 29276814
Administration related reaction 20.64 17.12 5 10128 82 29564312
Dependence 20.46 17.12 9 10124 1026 29563368
Product complaint 20.36 17.12 16 10117 5389 29559005
Kussmaul respiration 20.00 17.12 5 10128 94 29564300
Product use in unapproved indication 19.92 17.12 3 10130 86872 29477522
Amnesia 19.73 17.12 31 10102 22612 29541782
Sinus tachycardia 19.62 17.12 25 10108 15044 29549350
Back injury 19.24 17.12 13 10120 3471 29560923
Unresponsive to stimuli 18.65 17.12 32 10101 25094 29539300
Accidental poisoning 18.40 17.12 7 10126 551 29563843
Myofascial pain syndrome 18.31 17.12 6 10127 304 29564090
Somnolence 18.23 17.12 72 10061 93883 29470511
Coronary artery disease 18.12 17.12 44 10089 44146 29520248
Mental disorder due to a general medical condition 17.84 17.12 5 10128 148 29564246
Drug interaction 17.84 17.12 25 10108 197360 29367034

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1913.91 13.38 1170 25409 223244 64248909
Respiratory arrest 1044.72 13.38 485 26094 52500 64419653
Cardiac arrest 613.60 13.38 507 26072 153557 64318596
Toxicity to various agents 592.02 13.38 736 25843 362777 64109376
Cardio-respiratory arrest 406.13 13.38 331 26248 98062 64374091
Drug abuse 362.41 13.38 353 26226 132021 64340132
Overdose 347.19 13.38 376 26203 159190 64312963
Drug abuser 231.74 13.38 88 26491 5720 64466433
Intentional product misuse 211.16 13.38 200 26379 72095 64400058
Poisoning 205.07 13.38 122 26457 21757 64450396
Drug dependence 203.81 13.38 142 26437 33170 64438983
Drug withdrawal syndrome 181.24 13.38 129 26450 31162 64440991
Accidental overdose 173.15 13.38 129 26450 33428 64438725
Off label use 104.81 13.38 66 26513 632740 63839413
Depression 100.98 13.38 229 26350 183062 64289091
Exposure via ingestion 99.83 13.38 46 26533 4856 64467297
Unresponsive to stimuli 78.07 13.38 100 26479 50293 64421860
Anxiety 72.16 13.38 215 26364 202434 64269719
Accidental death 66.74 13.38 32 26547 3693 64468460
Intentional overdose 66.62 13.38 127 26452 89817 64382336
Neutropenia 63.75 13.38 11 26568 239613 64232540
Dependence 62.70 13.38 26 26553 2129 64470024
Drug screen positive 61.75 13.38 35 26544 5694 64466459
Coma 61.57 13.38 121 26458 87494 64384659
Acute kidney injury 54.50 13.38 63 26516 449177 64022976
Urinary bladder rupture 50.72 13.38 11 26568 87 64472066
Inadequate analgesia 50.29 13.38 27 26552 3951 64468202
Product use in unapproved indication 49.47 13.38 7 26572 176611 64295542
Insomnia 49.15 13.38 186 26393 197650 64274503
Road traffic accident 47.59 13.38 61 26518 30684 64441469
Drug intolerance 45.08 13.38 11 26568 187981 64284172
Febrile neutropenia 44.96 13.38 11 26568 187646 64284507
Thrombocytopenia 38.79 13.38 22 26557 223779 64248374
Emotional distress 38.67 13.38 60 26519 35978 64436175
Pyrexia 38.51 13.38 111 26468 558533 63913620
Blood pH decreased 34.72 13.38 22 26557 4380 64467773
Treatment failure 34.22 13.38 4 26575 116812 64355341
Infusion related reaction 33.37 13.38 13 26566 164454 64307699
Coronary artery disease 32.64 13.38 75 26504 60358 64411795
Substance abuse 31.55 13.38 28 26551 9264 64462889
Pancytopenia 31.34 13.38 10 26569 143299 64328854
Narcotic bowel syndrome 31.19 13.38 9 26570 245 64471908
Injury 30.80 13.38 70 26509 55922 64416231
Hypoaesthesia 30.65 13.38 126 26453 138982 64333171
Renal impairment 30.29 13.38 9 26570 135008 64337145
Synovitis 30.03 13.38 3 26576 99087 64373066
Joint swelling 29.70 13.38 27 26552 215355 64256798
Lethargy 29.65 13.38 81 26498 72513 64399640
Interstitial lung disease 29.51 13.38 3 26576 97729 64374424
Suicidal ideation 28.94 13.38 76 26503 66466 64405687
Tarsal tunnel syndrome 28.93 13.38 10 26569 495 64471658
Leukopenia 28.37 13.38 4 26575 101238 64370915
Nervousness 27.33 13.38 46 26533 29510 64442643
Intervertebral disc degeneration 26.83 13.38 30 26549 13090 64459063
Suicide attempt 26.81 13.38 77 26502 70930 64401223
Intervertebral disc protrusion 26.55 13.38 37 26542 20154 64451999
Spinal epidural haematoma 26.37 13.38 12 26567 1230 64470923
Malignant neoplasm progression 26.29 13.38 7 26572 112864 64359289
C-reactive protein increased 26.01 13.38 4 26575 94905 64377248
Cardiac failure 25.97 13.38 11 26568 132362 64339791
Sinus tachycardia 25.74 13.38 47 26532 32141 64440012
Hyperlipidaemia 25.69 13.38 39 26540 22937 64449216
General physical health deterioration 25.46 13.38 28 26551 204397 64267756
Purpura senile 25.01 13.38 9 26570 502 64471651
Infection 24.52 13.38 24 26555 184856 64287297
Sepsis 24.08 13.38 36 26543 230305 64241848
Arteriosclerosis 23.78 13.38 31 26548 15846 64456307
Drug interaction 23.42 13.38 74 26505 362009 64110144
Death 23.22 13.38 302 26277 482403 63989750
Amnesia 22.93 13.38 57 26522 48212 64423941
Condition aggravated 22.79 13.38 78 26501 372348 64099805
Anaemia 22.71 13.38 80 26499 378600 64093553
Respiratory rate decreased 22.56 13.38 17 26562 4474 64467679
Loss of consciousness 22.13 13.38 120 26459 148245 64323908
Drug ineffective 22.01 13.38 231 26348 840016 63632137
Migraine 21.78 13.38 66 26513 62611 64409542
Somnolence 21.71 13.38 151 26428 203494 64268659
Diarrhoea 21.30 13.38 193 26386 722511 63749642
Epistaxis 21.18 13.38 7 26572 98124 64374029
Pain 20.92 13.38 332 26247 553179 63918974
Pupillary reflex impaired 20.91 13.38 14 26565 3059 64469094
Pulmonary congestion 20.55 13.38 36 26543 23844 64448309
Soft tissue haemorrhage 20.30 13.38 7 26572 344 64471809
Irritability 20.27 13.38 46 26533 36700 64435453
Back pain 20.27 13.38 174 26405 249997 64222156
Rash 20.11 13.38 109 26470 458440 64013713
Drug tolerance 19.99 13.38 18 26561 6067 64466086
Hyponatraemia 19.96 13.38 19 26560 148320 64323833
Back injury 19.88 13.38 20 26559 7737 64464416
Disease progression 19.24 13.38 18 26561 141662 64330491
Chest pain 19.04 13.38 164 26415 235816 64236337
Ventricular hypertrophy 18.94 13.38 18 26561 6498 64465655
Product complaint 18.94 13.38 24 26555 11930 64460223
Neck pain 18.82 13.38 62 26517 61471 64410682
Peripheral swelling 18.81 13.38 36 26543 209117 64263036
Quadriplegia 18.78 13.38 13 26566 3000 64469153
Stomatitis 18.65 13.38 11 26568 109594 64362559
Respiratory depression 18.45 13.38 34 26545 23409 64448744
Intervertebral disc disorder 18.34 13.38 15 26564 4442 64467711
Lower respiratory tract infection 18.34 13.38 8 26571 94606 64377547
Progressive multiple sclerosis 17.88 13.38 8 26571 788 64471365
Resorption bone increased 17.84 13.38 9 26570 1159 64470994
Systemic lupus erythematosus 17.72 13.38 5 26574 77607 64394546
Administration related reaction 17.70 13.38 5 26574 126 64472027
Tremor 17.65 13.38 113 26466 148117 64324036
Product use issue 17.57 13.38 22 26557 151693 64320460
Septic shock 17.36 13.38 11 26568 105426 64366727
Wound 17.32 13.38 5 26574 76472 64395681
Feeling abnormal 17.25 13.38 104 26475 133498 64338655
Arteriosclerosis coronary artery 16.86 13.38 26 26553 15503 64456650
Platelet count decreased 16.77 13.38 27 26552 167684 64304469
Atrial fibrillation 16.68 13.38 28 26551 171061 64301092
Dyspnoea 16.65 13.38 203 26376 718471 63753682
Hyperhidrosis 16.61 13.38 98 26481 124822 64347331
Hypertensive heart disease 16.07 13.38 13 26566 3791 64468362
Accidental poisoning 15.99 13.38 9 26570 1444 64470709
Crying 15.64 13.38 29 26550 20061 64452092
White blood cell count decreased 15.23 13.38 26 26553 157811 64314342
Seizure 15.07 13.38 119 26460 166773 64305380
Depressed level of consciousness 15.05 13.38 70 26509 81366 64390787
Hepatic enzyme increased 14.88 13.38 19 26560 129924 64342229
Paranoia 14.52 13.38 25 26554 16327 64455826
Paraesthesia 14.47 13.38 100 26479 134422 64337731
Neck injury 14.44 13.38 10 26569 2308 64469845
Mydriasis 14.38 13.38 24 26555 15288 64456865
Mucosal inflammation 14.34 13.38 4 26575 62580 64409573
Gastrooesophageal reflux disease 14.30 13.38 70 26509 83073 64389080
Myofascial pain syndrome 14.22 13.38 9 26570 1789 64470364
Spinal osteoarthritis 14.17 13.38 23 26556 14318 64457835
Generalised anxiety disorder 13.70 13.38 9 26570 1906 64470247
Alopecia 13.63 13.38 30 26549 165660 64306493
Hyperkalaemia 13.55 13.38 13 26566 101116 64371037
Hypersensitivity 13.51 13.38 39 26540 196413 64275740
COVID-19 13.45 13.38 5 26574 65135 64407018

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03BA02 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA52 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA72 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
CHEBI has role CHEBI:51371 muscle relaxants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018373 Peripheral Nervous System Agents
FDA PE N0000175730 Centrally-mediated Muscle Relaxation
FDA EPC N0000175737 Muscle Relaxant

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Spasticity indication 221360009
Muscle Spasm with Pain indication
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Sedation contraindication 72641008
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Epilepsy contraindication 84757009 DOID:1826
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
von Willebrand disorder contraindication 128105004 DOID:12531
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Dysfunction of sphincter of Oddi contraindication 430887001
Acute erosive gastritis contraindication 444926003
Acute exacerbation of asthma contraindication 708038006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018454 VUID
N0000146778 NUI
D00768 KEGG_DRUG
2101 RXNORM
C0007248 UMLSCUI
CHEBI:3419 CHEBI
CHEMBL1233 ChEMBL_ID
DB00395 DRUGBANK_ID
D002328 MESH_DESCRIPTOR_UI
2576 PUBCHEM_CID
7610 IUPHAR_LIGAND_ID
902 INN_ID
21925K482H UNII
4359 MMSL
747 MMSL
d00960 MMSL
001672 NDDF
25076002 SNOMEDCT_US
387133006 SNOMEDCT_US
4018454 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Soma HUMAN PRESCRIPTION DRUG LABEL 1 0037-2001 TABLET 350 mg ORAL NDA 31 sections
Soma HUMAN PRESCRIPTION DRUG LABEL 1 0037-2250 TABLET 250 mg ORAL NDA 31 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0143-1176 TABLET 350 mg ORAL ANDA 29 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0591-5513 TABLET 350 mg ORAL ANDA 25 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 10544-033 TABLET 350 mg ORAL ANDA 28 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 10544-088 TABLET 350 mg ORAL ANDA 29 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 10544-132 TABLET 350 mg ORAL ANDA 27 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 12634-437 TABLET 350 mg ORAL ANDA 32 sections
carisoprodol Human Prescription Drug Label 1 16571-780 TABLET 250 mg ORAL ANDA 29 sections
carisoprodol Human Prescription Drug Label 1 16571-781 TABLET 350 mg ORAL ANDA 29 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 16590-039 TABLET 350 mg ORAL ANDA 27 sections
SOMA HUMAN PRESCRIPTION DRUG LABEL 1 16590-755 TABLET 250 mg ORAL NDA 29 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 16714-510 TABLET 350 mg ORAL ANDA 32 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL WITH HIGHLIGHTS 1 21695-021 TABLET 350 mg ORAL ANDA 29 sections
Carisoprodol and Aspirin HUMAN PRESCRIPTION DRUG LABEL 2 21695-570 TABLET 200 mg ORAL ANDA 19 sections
Soma HUMAN PRESCRIPTION DRUG LABEL 1 21695-606 TABLET 250 mg ORAL NDA 29 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 29033-207 TABLET 250 mg ORAL ANDA 30 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 29033-214 TABLET 350 mg ORAL ANDA 30 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 33261-387 TABLET 350 mg ORAL ANDA 28 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 33358-064 TABLET 350 mg ORAL ANDA 29 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42543-700 TABLET 350 mg ORAL ANDA 30 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42549-503 TABLET 350 mg ORAL ANDA 27 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 43063-824 TABLET 350 mg ORAL ANDA 32 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 43353-102 TABLET 350 mg ORAL ANDA 31 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 45865-984 TABLET 350 mg ORAL ANDA 30 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 49999-064 TABLET 350 mg ORAL ANDA 29 sections
Carisoprodol Human Prescription Drug Label 1 50090-0280 TABLET 350 mg ORAL ANDA 30 sections
Carisoprodol Human Prescription Drug Label 1 50090-0281 TABLET 350 mg ORAL ANDA 30 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 50090-3048 TABLET 350 mg ORAL ANDA 32 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 50090-3232 TABLET 350 mg ORAL ANDA 33 sections