eftrenonacog alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
blood factor IX	5084	1270012-74-2

Description:

Molecule

Description

Synonyms:

eftrenonacog alfa
alprolix
eftrenonacog alfa (genetical recombination)

consists of factor IX fused to the Fc fragment of human IgG1

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 12, 2016	EMA	Swedish Orphan Biovitrum AB

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemorrhage	1024.66	68.47	258	1098	51112	34904463
Haemarthrosis	374.12	68.47	70	1286	3189	34952386
Factor IX inhibition	175.89	68.47	23	1333	82	34955493
Spontaneous haemorrhage	157.84	68.47	24	1332	296	34955279
Traumatic haemorrhage	96.89	68.47	18	1338	773	34954802
Contusion	95.76	68.47	40	1316	36324	34919251
Muscle haemorrhage	93.99	68.47	23	1333	3695	34951880

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemorrhage	932.42	61.24	222	968	90896	79652302
Haemarthrosis	360.48	61.24	64	1126	5748	79737450
Spontaneous haemorrhage	150.71	61.24	23	1167	794	79742404
Factor IX inhibition	144.09	61.24	17	1173	71	79743127
Muscle haemorrhage	103.81	61.24	23	1167	6277	79736921
Traumatic haemorrhage	84.50	61.24	15	1175	1318	79741880
Contusion	75.57	61.24	39	1151	148737	79594461

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hereditary factor IX deficiency disease	indication	41788008	DOID:12259

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
02E00T2QDE	UNII
D10522	KEGG_DRUG
C3818700	UMLSCUI
CHEMBL4594598	ChEMBL_ID
DB11608	DRUGBANK_ID
9660	INN_ID
C000599709	MESH_SUPPLEMENTAL_RECORD_UI
1535944	RXNORM
220196	MMSL
718942000	SNOMEDCT_US

Pharmaceutical products:

None