All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

pegaspargase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5082	130167-69-0

Description:

Molecule	Description
Synonyms: pegaspargase oncaspar	covalent attachment of PEG to enzyme produces active, stable complex; non-immunogenic; used in treatment of leukemia Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Feb. 1, 1994	FDA	SIGMA TAU
June 26, 2023	PMDA	Nihon Servier Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1477.93	31.55	619	12078	157730	90458020
Febrile bone marrow aplasia	916.84	31.55	223	12474	9515	90606235
Hypofibrinogenaemia	445.63	31.55	87	12610	1283	90614467
Hypertriglyceridaemia	402.23	31.55	111	12586	7778	90607972
Hyperbilirubinaemia	211.82	31.55	78	12619	13858	90601892
Neutropenia	191.17	31.55	194	12503	224710	90391040
Blood culture positive	167.76	31.55	51	12646	5021	90610729
Rhinovirus infection	155.52	31.55	50	12647	5913	90609837
Sepsis	148.84	31.55	153	12544	179661	90436089
Pancreatitis	147.24	31.55	102	12595	69724	90546026
Human bocavirus infection	141.45	31.55	28	12669	444	90615306
Superior sagittal sinus thrombosis	137.62	31.55	30	12667	776	90614974
Mucosal inflammation	130.54	31.55	88	12609	57537	90558213
Bacterial infection	126.52	31.55	63	12634	23381	90592369
Hepatocellular injury	122.30	31.55	66	12631	28892	90586858
Enterobacter infection	120.86	31.55	34	12663	2549	90613201
Neurotoxicity	116.77	31.55	58	12639	21409	90594341
Venoocclusive liver disease	115.45	31.55	40	12657	5953	90609797
Posterior reversible encephalopathy syndrome	114.58	31.55	58	12639	22281	90593469
Myelosuppression	109.94	31.55	77	12620	53514	90562236
Hyperglycaemia	108.70	31.55	75	12622	50895	90564855
Mucormycosis	103.58	31.55	33	12664	3788	90611962
Human herpesvirus 6 infection	102.86	31.55	32	12665	3400	90612350
Pyrexia	101.22	31.55	259	12438	660226	89955524
Herpes simplex	98.19	31.55	41	12656	10140	90605610
Septic shock	96.89	31.55	86	12611	84074	90531676
Gastroenteritis norovirus	96.46	31.55	28	12669	2348	90613402
Secondary immunodeficiency	95.02	31.55	27	12670	2099	90613651
Bacteraemia	91.85	31.55	50	12647	22250	90593500
Perineal necrosis	91.07	31.55	16	12681	126	90615624
Pneumatosis intestinalis	90.36	31.55	29	12668	3408	90612342
Lipase increased	88.23	31.55	39	12658	11072	90604678
Hypoalbuminaemia	86.59	31.55	43	12654	15854	90599896
Perineal infection	86.00	31.55	16	12681	179	90615571
Pyomyositis	84.54	31.55	18	12679	415	90615335
Pancytopenia	82.95	31.55	93	12604	120170	90495580
Blood fibrinogen decreased	81.09	31.55	21	12676	1149	90614601
Venous thrombosis	80.46	31.55	30	12667	5507	90610243
Fusarium infection	77.81	31.55	20	12677	1062	90614688
Hypotension	75.87	31.55	151	12546	325246	90290504
Pancreatitis acute	72.58	31.55	49	12648	32066	90583684
Bone marrow failure	72.44	31.55	49	12648	32172	90583578
Hepatic failure	72.10	31.55	53	12644	39675	90576075
Colitis	71.73	31.55	67	12630	69875	90545875
Coagulopathy	71.21	31.55	43	12654	23246	90592504
Multiple organ dysfunction syndrome	69.19	31.55	65	12632	68271	90547479
Potentiating drug interaction	69.06	31.55	27	12670	5635	90610115
Pseudomonal sepsis	68.76	31.55	25	12672	4277	90611473
Fatigue	66.40	31.55	40	12657	1153983	89461767
Antithrombin III decreased	64.33	31.55	13	12684	230	90615520
Thrombocytopenia	63.91	31.55	109	12588	208616	90407134
Alanine aminotransferase increased	62.65	31.55	80	12617	118258	90497492
Pseudomonas test positive	61.35	31.55	16	12681	900	90614850
Blood bilirubin increased	59.34	31.55	49	12648	43421	90572329
Rhinocerebral mucormycosis	58.35	31.55	15	12682	797	90614953
Alopecia	57.11	31.55	3	12694	495068	90120682
Antithrombin III	56.71	31.55	11	12686	156	90615594
Tachycardia	55.90	31.55	88	12609	157585	90458165
Cystitis bacterial	54.02	31.55	12	12685	339	90615411
Enteritis	53.50	31.55	27	12670	10294	90605456
Acute lymphocytic leukaemia recurrent	51.78	31.55	18	12679	2703	90613047
Seizure	51.10	31.55	83	12614	152546	90463204
Arthralgia	50.57	31.55	23	12674	778499	89837251
Clostridium difficile colitis	49.29	31.55	36	12661	26670	90589080
Neutrophil count decreased	48.74	31.55	55	12642	71477	90544273
Device related infection	48.13	31.55	35	12662	25751	90589999
Pulmonary haemorrhage	47.60	31.55	23	12674	7990	90607760
Transverse sinus thrombosis	47.29	31.55	12	12685	605	90615145
Respiratory distress	47.20	31.55	41	12656	38905	90576845
Staphylococcal sepsis	47.04	31.55	24	12673	9359	90606391
Alpha haemolytic streptococcal infection	46.93	31.55	15	12682	1739	90614011
Cerebral venous thrombosis	46.62	31.55	16	12681	2312	90613438
Clostridium test positive	46.26	31.55	20	12677	5381	90610369
Endophthalmitis	45.61	31.55	19	12678	4666	90611084
Neuropathy peripheral	45.19	31.55	74	12623	136896	90478854
Escherichia bacteraemia	45.11	31.55	20	12677	5715	90610035
Anaphylactic reaction	44.47	31.55	58	12639	87466	90528284
Abdominal discomfort	44.22	31.55	7	12690	477321	90138429
Weight increased	43.93	31.55	4	12693	417923	90197827
Pruritus	43.79	31.55	11	12686	541514	90074236
Cholestasis	43.55	31.55	38	12659	36261	90579489
Hepatotoxicity	43.34	31.55	42	12655	45800	90569950
Pain	42.87	31.55	46	12651	996295	89619455
Blood lactic acid increased	42.70	31.55	22	12675	8756	90606994
Rash	42.40	31.55	30	12667	796070	89819680
Disseminated intravascular coagulation	41.95	31.55	30	12667	21508	90594242
Aspergillus infection	41.08	31.55	23	12674	10800	90604950
Blood triglycerides increased	41.01	31.55	25	12672	13736	90602014
Drug ineffective	40.99	31.55	83	12614	1384215	89231535
Fungaemia	40.94	31.55	16	12681	3334	90612416
Respiratory failure	40.45	31.55	65	12632	118353	90497397
Hyperlipidaemia	40.28	31.55	30	12667	22886	90592864
Overgrowth fungal	39.30	31.55	8	12689	147	90615603
Pseudomonas infection	39.24	31.55	25	12672	14840	90600910
Hepatomegaly	39.18	31.55	24	12673	13302	90602448
Respiratory syncytial virus infection	39.04	31.55	22	12675	10458	90605292
Quadriparesis	37.73	31.55	14	12683	2535	90613215
Neutropenic colitis	37.66	31.55	16	12681	4127	90611623
Perirectal abscess	37.55	31.55	11	12686	952	90614798
Trichosporon infection	37.21	31.55	9	12688	372	90615378
Streptococcus test positive	37.19	31.55	12	12685	1433	90614317
Escherichia test positive	37.10	31.55	14	12683	2656	90613094
Cryptococcal fungaemia	35.85	31.55	7	12690	103	90615647
Nasopharyngitis	35.45	31.55	7	12690	407097	90208653
Leukoencephalopathy	35.16	31.55	16	12681	4857	90610893
Pancreatitis necrotising	34.96	31.55	13	12684	2368	90613382
Enterococcal infection	34.60	31.55	20	12677	9971	90605779
Osteonecrosis	34.60	31.55	29	12668	26212	90589538
Staphylococcal bacteraemia	34.27	31.55	18	12679	7451	90608299
Human rhinovirus test positive	33.83	31.55	10	12687	893	90614857
Hyperglycaemic hyperosmolar nonketotic syndrome	33.74	31.55	11	12686	1358	90614392
Bacillus infection	33.24	31.55	10	12687	949	90614801
Intracranial hypotension	32.88	31.55	8	12689	339	90615411
Condition aggravated	32.26	31.55	22	12675	595523	90020227
Ileus	32.11	31.55	23	12674	16523	90599227
Viral infection	31.95	31.55	34	12663	41380	90574370
Enterovirus test positive	31.78	31.55	7	12690	190	90615560
Treatment failure	31.68	31.55	3	12694	303925	90311825
Aplasia	31.65	31.55	14	12683	3977	90611773

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1069.79	21.92	742	15901	184961	42419731
Hypertriglyceridaemia	570.22	21.92	195	16448	9931	42594761
Hypofibrinogenaemia	569.32	21.92	136	16507	1831	42602861
Febrile bone marrow aplasia	406.48	21.92	152	16491	10029	42594663
Hyperbilirubinaemia	314.98	21.92	156	16487	20479	42584213
Mucosal inflammation	215.65	21.92	168	16475	49206	42555486
Myelosuppression	188.30	21.92	143	16500	40318	42564374
Pancreatitis	177.65	21.92	142	16501	43126	42561566
Neutropenia	154.85	21.92	278	16365	199153	42405539
Venoocclusive liver disease	134.11	21.92	70	16573	10232	42594460
Death	111.88	21.92	24	16619	471161	42133531
Coagulopathy	111.21	21.92	82	16561	22080	42582612
Blood fibrinogen decreased	106.50	21.92	35	16608	1568	42603124
Anaphylactic reaction	105.03	21.92	105	16538	42638	42562054
Hepatotoxicity	104.08	21.92	83	16560	25084	42579608
Posterior reversible encephalopathy syndrome	99.12	21.92	62	16581	12759	42591933
Leukoencephalopathy	92.34	21.92	43	16600	4911	42599781
Vomiting	86.81	21.92	279	16364	289444	42315248
Abdominal pain	82.91	21.92	210	16433	190261	42414431
Pancreatitis acute	81.61	21.92	82	16561	33482	42571210
Thrombocytopenia	73.82	21.92	201	16442	190078	42414614
Cerebral venous sinus thrombosis	73.30	21.92	22	16621	729	42603963
Septic shock	72.43	21.92	129	16514	91543	42513149
Hepatopulmonary syndrome	71.09	21.92	15	16628	109	42604583
Sepsis	70.87	21.92	204	16439	199130	42405562
Gallbladder oedema	70.69	21.92	17	16626	235	42604457
Blood bilirubin increased	67.72	21.92	83	16560	42169	42562523
Neurotoxicity	63.47	21.92	61	16582	23590	42581102
Cholestasis	63.37	21.92	71	16572	32808	42571884
Cerebral thrombosis	62.92	21.92	21	16622	987	42603705
Hepatocellular injury	61.53	21.92	60	16583	23618	42581074
Hyperglycaemia	60.80	21.92	82	16561	45777	42558915
Hepatic steatosis	60.76	21.92	57	16586	21391	42583301
Lentigo	58.60	21.92	19	16624	815	42603877
Antithrombin III deficiency	57.30	21.92	13	16630	137	42604555
Superior sagittal sinus thrombosis	55.92	21.92	15	16628	328	42604364
Steatohepatitis	55.25	21.92	16	16627	467	42604225
Aspergillus infection	54.56	21.92	47	16596	15790	42588902
Escherichia infection	54.54	21.92	41	16602	11355	42593337
Potentiating drug interaction	54.36	21.92	33	16610	6435	42598257
Pyrexia	51.48	21.92	295	16348	393747	42210945
Acute lymphocytic leukaemia recurrent	50.67	21.92	26	16617	3665	42601027
Alanine aminotransferase increased	49.86	21.92	108	16535	88298	42516394
Colitis	49.55	21.92	75	16568	46497	42558195
Fibrinous bronchitis	48.47	21.92	11	16632	116	42604576
Product dose omission issue	48.38	21.92	3	16640	154362	42450330
Blood culture positive	48.27	21.92	28	16615	5025	42599667
Cerebral venous thrombosis	46.88	21.92	17	16626	1024	42603668
Lipase increased	46.14	21.92	36	16607	10530	42594162
Enterococcus test positive	45.57	21.92	19	16624	1666	42603026
Bone marrow failure	45.11	21.92	60	16583	33033	42571659
Ascites	45.03	21.92	80	16563	56598	42548094
Bacteraemia	44.73	21.92	52	16591	24988	42579704
Tachycardia	44.43	21.92	112	16531	100975	42503717
Antithrombin III decreased	44.11	21.92	14	16629	560	42604132
Hepatomegaly	42.69	21.92	36	16607	11749	42592943
Fatigue	41.95	21.92	66	16577	435575	42169117
Hypertransaminasaemia	41.51	21.92	32	16611	9195	42595497
Fungal infection	40.43	21.92	44	16599	19678	42585014
Mucormycosis	39.39	21.92	28	16615	7115	42597577
Oesophageal stenosis	38.88	21.92	18	16625	2028	42602664
Candida infection	38.80	21.92	45	16598	21565	42583127
Venoocclusive disease	38.21	21.92	22	16621	3893	42600799
Gastrointestinal wall thickening	37.52	21.92	17	16626	1822	42602870
Pneumonia viral	36.42	21.92	22	16621	4252	42600440
Haemophagocytic lymphohistiocytosis	36.21	21.92	40	16603	18182	42586510
Pneumonia fungal	35.33	21.92	29	16614	9117	42595575
Escherichia sepsis	35.13	21.92	24	16619	5723	42598969
Pseudomonas test positive	34.60	21.92	15	16628	1448	42603244
Parainfluenzae virus infection	34.30	21.92	20	16623	3623	42601069
Dyspnoea	33.86	21.92	77	16566	442544	42162148
Periorbital infection	33.85	21.92	9	16634	190	42604502
Condition aggravated	32.93	21.92	32	16611	260722	42343970
Intussusception	32.71	21.92	12	16631	747	42603945
Respiratory distress	31.89	21.92	58	16585	41762	42562930
Osteonecrosis	31.83	21.92	35	16608	15830	42588862
Drug ineffective	31.63	21.92	133	16510	630064	41974628
Stomatitis	31.28	21.92	64	16579	50265	42554427
Scedosporium infection	30.52	21.92	14	16629	1544	42603148
Escherichia bacteraemia	30.29	21.92	21	16622	5128	42599564
Depression	29.99	21.92	4	16639	111359	42493333
Aplasia	29.07	21.92	20	16623	4823	42599869
Cytomegalovirus hepatitis	28.93	21.92	10	16633	523	42604169
Atypical haemolytic uraemic syndrome	28.47	21.92	10	16633	549	42604143
Insomnia	27.98	21.92	6	16637	118247	42486445
Vascular access complication	27.49	21.92	9	16634	398	42604294
Cytopenia	27.41	21.92	34	16609	17463	42587229
Fall	27.11	21.92	31	16612	234489	42370203
Mucosal infection	27.04	21.92	8	16635	252	42604440
Tumour lysis syndrome	26.81	21.92	38	16605	22193	42582499
Drug clearance decreased	26.07	21.92	14	16629	2164	42602528
Optic nerve disorder	25.89	21.92	10	16633	718	42603974
Peripheral swelling	24.89	21.92	3	16640	90267	42514425
Prothrombin level abnormal	24.68	21.92	6	16637	87	42604605
Brain oedema	24.42	21.92	31	16612	16296	42588396
Multiple lentigines syndrome	24.39	21.92	5	16638	31	42604661
Seizure	24.03	21.92	102	16541	120459	42484233
Acral lentiginous melanoma	23.99	21.92	5	16638	34	42604658
Hypoalbuminaemia	23.92	21.92	30	16613	15580	42589112
Overdose	23.60	21.92	6	16637	105258	42499434
Urinary tract infection	23.56	21.92	5	16638	99279	42505413
Neutropenic colitis	23.45	21.92	17	16626	4453	42600239
Gamma-glutamyltransferase increased	23.43	21.92	44	16599	32453	42572239
Mixed anxiety and depressive disorder	23.20	21.92	7	16636	236	42604456
Hypersensitivity	22.72	21.92	71	16572	72299	42532393
Meningitis bacterial	22.50	21.92	11	16632	1398	42603294

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	2265.68	24.34	1252	27407	315515	110245125
Hypertriglyceridaemia	872.95	24.34	273	28386	15881	110544759
Febrile bone marrow aplasia	643.66	24.34	221	28438	17244	110543396
Hypofibrinogenaemia	522.86	24.34	123	28536	2384	110558256
Secondary immunodeficiency	414.58	24.34	116	28543	4560	110556080
Hyperbilirubinaemia	356.02	24.34	169	28490	30502	110530138
Mucosal inflammation	329.37	24.34	240	28419	95901	110464739
Neutropenia	324.09	24.34	440	28219	374180	110186460
Bacterial infection	315.50	24.34	178	28481	45858	110514782
Pancreatitis	294.59	24.34	222	28437	93311	110467329
Human bocavirus infection	281.25	24.34	64	28595	1064	110559576
Myelosuppression	277.51	24.34	215	28444	94125	110466515
Pseudomonal sepsis	251.79	24.34	93	28566	8953	110551687
Rhinovirus infection	238.17	24.34	96	28563	11693	110548947
Mycobacterium chelonae infection	226.69	24.34	66	28593	2994	110557646
Cystitis bacterial	212.33	24.34	52	28607	1201	110559439
Enterobacter infection	208.04	24.34	72	28587	5739	110554901
Posterior reversible encephalopathy syndrome	202.86	24.34	120	28539	33741	110526899
Norovirus test positive	199.15	24.34	47	28612	923	110559717
Thymus hypoplasia	196.97	24.34	52	28607	1635	110559005
Clostridium difficile colitis	196.19	24.34	129	28530	43649	110516991
Human herpesvirus 6 infection	191.81	24.34	70	28589	6511	110554129
Blood culture positive	187.92	24.34	75	28584	8901	110551739
Aspergillus infection	186.21	24.34	103	28556	25513	110535127
Lymphoid tissue hypoplasia	183.36	24.34	49	28610	1616	110559024
Sepsis	181.38	24.34	313	28346	327033	110233607
Viral infection	171.37	24.34	128	28531	53011	110507629
Superior sagittal sinus thrombosis	171.01	24.34	43	28616	1110	110559530
Pneumatosis intestinalis	170.72	24.34	69	28590	8460	110552180
Coagulopathy	167.56	24.34	114	28545	40797	110519843
Venoocclusive liver disease	164.89	24.34	80	28579	15127	110545513
Hepatotoxicity	159.71	24.34	132	28527	63268	110497372
Parainfluenzae virus infection	159.06	24.34	62	28597	6912	110553728
Septic shock	155.90	24.34	198	28461	157330	110403310
Pancreatitis acute	152.89	24.34	126	28533	60148	110500492
Blood fibrinogen decreased	151.91	24.34	47	28612	2628	110558012
Neurotoxicity	150.41	24.34	108	28551	42099	110518541
Thrombocytopenia	139.11	24.34	290	28369	348595	110212045
Bronchopulmonary aspergillosis	136.23	24.34	89	28570	29774	110530866
Hyperglycaemia	131.88	24.34	135	28524	84955	110475685
Pyrexia	131.36	24.34	519	28140	897746	109662894
Enteritis	128.28	24.34	73	28586	19083	110541557
Mucormycosis	127.68	24.34	60	28599	10568	110550072
Viraemia	124.65	24.34	45	28614	4057	110556583
Leukoencephalopathy	120.08	24.34	55	28604	9140	110551500
Bacteraemia	116.76	24.34	93	28566	42297	110518343
Lipase increased	116.62	24.34	68	28591	18604	110542036
Fungal infection	114.02	24.34	99	28560	50707	110509933
Colitis	111.44	24.34	135	28524	102188	110458452
Bone marrow failure	110.64	24.34	103	28556	57745	110502895
Anaphylactic reaction	107.28	24.34	140	28519	114160	110446480
Blood bilirubin increased	106.05	24.34	114	28545	75858	110484782
Fatigue	100.00	24.34	101	28558	1215857	109344783
Acute lymphocytic leukaemia recurrent	96.17	24.34	41	28618	5746	110554894
Intracardiac thrombus	94.00	24.34	37	28622	4231	110556409
Pancytopenia	93.88	24.34	183	28476	209430	110351210
Abscess bacterial	91.11	24.34	25	28634	912	110559728
Antithrombin III decreased	90.24	24.34	22	28637	498	110560142
Cerebral venous sinus thrombosis	88.87	24.34	32	28627	2863	110557777
Cholestasis	88.61	24.34	96	28563	64422	110496218
Pseudomonas test positive	87.49	24.34	30	28629	2324	110558316
Alanine aminotransferase increased	85.41	24.34	163	28496	183610	110377030
Hypoalbuminaemia	82.86	24.34	65	28594	28909	110531731
Hepatocellular injury	79.63	24.34	81	28578	50561	110510079
Venous thrombosis	78.17	24.34	40	28619	8465	110552175
Perineal necrosis	76.68	24.34	16	28643	173	110560467
Tachycardia	75.03	24.34	175	28484	226470	110334170
Hepatomegaly	74.46	24.34	54	28605	21360	110539280
Oral herpes	74.35	24.34	67	28592	36013	110524627
Nasopharyngitis	73.97	24.34	8	28651	394353	110166287
Pain	73.18	24.34	84	28575	954871	109605769
Condition aggravated	72.58	24.34	51	28608	734785	109825855
Seizure	70.19	24.34	168	28491	221017	110339623
Arthralgia	68.34	24.34	61	28598	779571	109781069
Pyomyositis	68.02	24.34	19	28640	741	110559899
Pneumonia fungal	67.35	24.34	44	28615	14710	110545930
Lentigo	67.34	24.34	19	28640	769	110559871
Enterococcus test positive	66.87	24.34	26	28633	2878	110557762
Hepatic failure	65.72	24.34	85	28574	68654	110491986
Device related infection	65.41	24.34	65	28594	39454	110521186
Candida infection	65.16	24.34	71	28588	47938	110512702
Fall	64.88	24.34	38	28621	603444	109957196
Peripheral swelling	64.73	24.34	13	28646	404021	110156619
Alopecia	64.49	24.34	9	28650	364744	110195896
Oesophageal candidiasis	64.19	24.34	39	28620	11495	110549145
Malaise	63.25	24.34	49	28610	671770	109888870
Hepatic steatosis	62.45	24.34	70	28589	48761	110511879
Tumour lysis syndrome	61.12	24.34	56	28603	30745	110529895
Fusarium infection	60.95	24.34	24	28635	2747	110557893
Neutrophil count decreased	60.82	24.34	111	28548	120830	110439810
Pulmonary haemorrhage	60.66	24.34	43	28616	16413	110544227
Multiple organ dysfunction syndrome	60.20	24.34	126	28533	151584	110409056
Cytomegalovirus viraemia	59.96	24.34	44	28615	17720	110542920
Ascites	59.64	24.34	95	28564	92713	110467927
Diffuse alveolar damage	58.53	24.34	26	28633	4021	110556619
Abdominal discomfort	58.44	24.34	15	28644	393843	110166797
Hepatopulmonary syndrome	58.12	24.34	13	28646	199	110560441
Hypotension	58.10	24.34	279	28380	523570	110037070
Gastroenteritis norovirus	58.08	24.34	25	28634	3586	110557054
Escherichia infection	56.66	24.34	48	28611	23768	110536872
Abdominal pain	56.01	24.34	272	28387	512717	110047923
Antithrombin III deficiency	55.69	24.34	12	28647	153	110560487
Cytomegalovirus chorioretinitis	55.49	24.34	30	28629	7098	110553542
Drug ineffective	55.06	24.34	206	28453	1520334	109040306
Coronavirus infection	54.99	24.34	33	28626	9512	110551128
Drug intolerance	53.93	24.34	19	28640	406493	110154147
Cerebral venous thrombosis	53.84	24.34	23	28636	3239	110557401
Muscle spasms	53.82	24.34	5	28654	278152	110282488
Potentiating drug interaction	53.82	24.34	35	28624	11608	110549032
Insomnia	52.98	24.34	14	28645	360576	110200064
Dyspnoea	52.82	24.34	132	28527	1106740	109453900
Aplasia	52.70	24.34	30	28629	7843	110552797
Perineal infection	52.48	24.34	16	28643	851	110559789
Neutropenic colitis	52.02	24.34	30	28629	8035	110552605
Pruritus	51.52	24.34	45	28614	581515	109979125
Osteonecrosis	51.28	24.34	53	28606	33688	110526952
Therapeutic product effect decreased	51.23	24.34	3	28656	244313	110316327
Fibrinous bronchitis	50.71	24.34	11	28648	145	110560495
Venoocclusive disease	50.20	24.34	27	28632	6323	110554317
Cerebral thrombosis	49.66	24.34	20	28639	2428	110558212
Disseminated aspergillosis	49.41	24.34	20	28639	2460	110558180
Staphylococcal bacteraemia	48.93	24.34	38	28621	16650	110543990
Haemophagocytic lymphohistiocytosis	48.74	24.34	50	28609	31509	110529131
Clostridium test positive	48.53	24.34	32	28627	10861	110549779
Respiratory failure	48.45	24.34	144	28515	215188	110345452
Atrial fibrillation	47.60	24.34	3	28656	229639	110331001
Rhinocerebral mucormycosis	47.43	24.34	17	28642	1500	110559140
Dizziness	46.61	24.34	68	28591	698125	109862515
Mucosal infection	46.34	24.34	13	28646	515	110560125
Blood lactic acid increased	46.33	24.34	36	28623	15785	110544855
Respiratory distress	46.32	24.34	72	28587	68802	110491838
Steatohepatitis	46.29	24.34	16	28643	1269	110559371
Wound	45.93	24.34	4	28655	234433	110326207
Disseminated intravascular coagulation	45.78	24.34	55	28604	41231	110519409
Depression	45.34	24.34	13	28646	317322	110243318
Escherichia sepsis	45.34	24.34	30	28629	10242	110550398
Platelet count decreased	45.27	24.34	147	28512	230296	110330344
Pancreatitis necrotising	45.20	24.34	24	28635	5477	110555163
Musculoskeletal stiffness	44.81	24.34	9	28650	279813	110280827
Pseudomonal bacteraemia	44.40	24.34	22	28637	4349	110556291
Herpes simplex	44.28	24.34	35	28624	15729	110544911
Intentional product use issue	44.08	24.34	6	28653	247900	110312740
Urinary tract infection	43.70	24.34	15	28644	326267	110234373
Escherichia bacteraemia	43.21	24.34	29	28630	10135	110550505
Overdose	43.17	24.34	5	28654	233789	110326851
Weight increased	42.87	24.34	28	28631	419616	110141024
Brain oedema	42.21	24.34	46	28613	31052	110529588
Chemotherapeutic drug level increased	41.96	24.34	12	28647	510	110560130
Cytopenia	41.67	24.34	45	28614	30071	110530569
Neuropathy peripheral	41.38	24.34	121	28538	179156	110381484
Vomiting	41.31	24.34	388	28271	910287	109650353
Tachypnoea	41.27	24.34	51	28608	39344	110521296
Oesophageal stenosis	40.94	24.34	22	28637	5143	110555497
Enterovirus infection	40.72	24.34	18	28641	2752	110557888
Dry mouth	40.31	24.34	3	28656	199945	110360695
Fungaemia	40.22	24.34	23	28636	6063	110554577
Rash	39.80	24.34	97	28562	820867	109739773
Hyperammonaemia	39.68	24.34	31	28628	13701	110546939
Escherichia test positive	39.28	24.34	19	28640	3565	110557075
Human rhinovirus test positive	38.98	24.34	14	28645	1243	110559397
Discomfort	38.64	24.34	5	28654	214702	110345938
Cardiac ventricular thrombosis	38.52	24.34	18	28641	3129	110557511
Bacillus test positive	37.88	24.34	9	28650	182	110560458
Swelling	37.83	24.34	22	28637	351019	110209621
Pericarditis	37.34	24.34	6	28653	219108	110341532
Transverse sinus thrombosis	37.24	24.34	12	28647	766	110559874
Enterocolitis infectious	36.97	24.34	18	28641	3426	110557214
Hypertransaminasaemia	36.68	24.34	38	28621	24217	110536423
Death	35.92	24.34	80	28579	698789	109861851
Intussusception	35.51	24.34	14	28645	1607	110559033
Hypophagia	35.36	24.34	55	28604	52571	110508069
Streptococcus test positive	35.28	24.34	16	28643	2598	110558042
Cellulitis	34.97	24.34	91	28568	125925	110434715
Sleep disorder	34.86	24.34	5	28654	198639	110362001
Enterocolitis	34.79	24.34	33	28626	18916	110541724
Overgrowth fungal	34.09	24.34	8	28651	153	110560487
Pseudomonas infection	34.03	24.34	39	28620	27814	110532826
Drug clearance decreased	33.91	24.34	18	28641	4104	110556536
Myocardial infarction	33.32	24.34	5	28654	192078	110368562
Hyperglycaemic hyperosmolar nonketotic syndrome	33.13	24.34	16	28643	2993	110557647
Scedosporium infection	33.03	24.34	15	28644	2443	110558197
Renal replacement therapy	32.45	24.34	8	28651	190	110560450
Arthritis	32.44	24.34	3	28656	167583	110393057
Injury	32.21	24.34	4	28655	177261	110383379
Gamma-glutamyltransferase increased	31.73	24.34	57	28602	61252	110499388
Mobility decreased	31.64	24.34	11	28648	237411	110323229
Stomatococcal infection	31.55	24.34	9	28650	379	110560261
Blister	31.23	24.34	10	28649	227366	110333274
Trichosporon infection	31.21	24.34	12	28647	1288	110559352
Intracranial hypotension	31.19	24.34	10	28649	628	110560012
Pleural effusion	31.03	24.34	109	28550	177600	110383040
Klebsiella infection	29.63	24.34	31	28628	19978	110540662
Staphylococcal sepsis	29.42	24.34	29	28630	17425	110543215
Hepatitis cholestatic	29.26	24.34	29	28630	17537	110543103
Musculoskeletal pain	29.06	24.34	6	28653	183017	110377623
Confusional state	28.99	24.34	48	28611	468632	110092008
Coagulation test abnormal	28.90	24.34	12	28647	1574	110559066
Diarrhoea	28.47	24.34	176	28483	1139329	109421311
Stenotrophomonas infection	28.04	24.34	18	28641	5840	110554800
Perirectal abscess	28.03	24.34	13	28646	2221	110558419
Cytomegalovirus hepatitis	27.75	24.34	10	28649	896	110559744
Type 2 diabetes mellitus	27.75	24.34	6	28653	177226	110383414
Soft tissue infection	27.73	24.34	17	28642	5090	110555550
Hypoxia	27.59	24.34	85	28574	129430	110431210
Apnoea	27.45	24.34	25	28634	13614	110547026
Candida sepsis	27.43	24.34	14	28645	2947	110557693
Enterococcal infection	27.42	24.34	30	28629	20336	110540304
Pulse absent	27.35	24.34	23	28636	11269	110549371
Minimal residual disease	27.26	24.34	10	28649	943	110559697
Antithrombin III	27.13	24.34	6	28653	87	110560553
General physical health deterioration	26.82	24.34	43	28616	425252	110135388
Anorectal cellulitis	26.52	24.34	6	28653	97	110560543
Vascular access complication	26.50	24.34	13	28646	2515	110558125
Mental status changes	26.50	24.34	60	28599	76062	110484578
Memory impairment	26.45	24.34	9	28650	196935	110363705
Hypogonadism	26.26	24.34	12	28647	1982	110558658
Contusion	26.03	24.34	14	28645	233347	110327293
Hepatic enzyme increased	25.84	24.34	27	28632	320865	110239775
Peripheral motor neuropathy	25.83	24.34	15	28644	4071	110556569
Pulmonary mucormycosis	25.43	24.34	12	28647	2131	110558509
Device related thrombosis	25.37	24.34	14	28645	3448	110557192
Product use issue	25.36	24.34	26	28633	311669	110248971
Unresponsive to stimuli	25.30	24.34	53	28606	63737	110496903
Cholangitis infective	24.73	24.34	9	28650	830	110559810
Anxiety	24.60	24.34	32	28627	345046	110215594
Lung disorder	24.58	24.34	8	28651	180039	110380601
Cryptococcal fungaemia	24.47	24.34	7	28652	298	110560342
Acral lentiginous melanoma	24.41	24.34	5	28654	49	110560591

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01XX24	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents
FDA CS	M0001815	Asparaginase
MeSH PA	D000970	Antineoplastic Agents
FDA EPC	N0000175669	Asparagine-specific Enzyme
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35705	immunosuppressive agent

Related Drugs by ATC class:

L01XX Other antineoplastic agents 33 drugs

adagrasibafliberceptaltretamineamsacrineanagrelidearsenic trioxideasparaginasebelzutifancalaspargase pegolcelecoxibdarinaparsindenileukin diftitox show all 33 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute lymphoid leukemia	indication	91857003	DOID:9952
Malignant lymphoma	indication	118600007	DOID:0060058

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
7D96IR0PPM	UNII
D05387	KEGG_DRUG
4020867	VANDF
C0071568	UMLSCUI
CHEBI:753505	CHEBI
CHEMBL2108546	ChEMBL_ID
DB00059	DRUGBANK_ID
6665	INN_ID
C042705	MESH_SUPPLEMENTAL_RECORD_UI
224911	RXNORM
11316	MMSL
5239	MMSL
d04247	MMSL
004476	NDDF
108814000	SNOMEDCT_US
416337002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ONCASPAR	HUMAN PRESCRIPTION DRUG LABEL	1	72694-954	INJECTION, SOLUTION	750 [iU]	INTRAVENOUS	BLA	31 sections