pegaspargase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5082 130167-69-0

Description:

MoleculeDescription

Synonyms:

  • pegaspargase
  • oncaspar
covalent attachment of PEG to enzyme produces active, stable complex; non-immunogenic; used in treatment of leukemia
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Feb. 1, 1994 FDA SIGMA TAU
June 26, 2023 PMDA Nihon Servier Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1477.93 31.55 619 12078 157730 90458020
Febrile bone marrow aplasia 916.84 31.55 223 12474 9515 90606235
Hypofibrinogenaemia 445.63 31.55 87 12610 1283 90614467
Hypertriglyceridaemia 402.23 31.55 111 12586 7778 90607972
Hyperbilirubinaemia 211.82 31.55 78 12619 13858 90601892
Neutropenia 191.17 31.55 194 12503 224710 90391040
Blood culture positive 167.76 31.55 51 12646 5021 90610729
Rhinovirus infection 155.52 31.55 50 12647 5913 90609837
Sepsis 148.84 31.55 153 12544 179661 90436089
Pancreatitis 147.24 31.55 102 12595 69724 90546026
Human bocavirus infection 141.45 31.55 28 12669 444 90615306
Superior sagittal sinus thrombosis 137.62 31.55 30 12667 776 90614974
Mucosal inflammation 130.54 31.55 88 12609 57537 90558213
Bacterial infection 126.52 31.55 63 12634 23381 90592369
Hepatocellular injury 122.30 31.55 66 12631 28892 90586858
Enterobacter infection 120.86 31.55 34 12663 2549 90613201
Neurotoxicity 116.77 31.55 58 12639 21409 90594341
Venoocclusive liver disease 115.45 31.55 40 12657 5953 90609797
Posterior reversible encephalopathy syndrome 114.58 31.55 58 12639 22281 90593469
Myelosuppression 109.94 31.55 77 12620 53514 90562236
Hyperglycaemia 108.70 31.55 75 12622 50895 90564855
Mucormycosis 103.58 31.55 33 12664 3788 90611962
Human herpesvirus 6 infection 102.86 31.55 32 12665 3400 90612350
Pyrexia 101.22 31.55 259 12438 660226 89955524
Herpes simplex 98.19 31.55 41 12656 10140 90605610
Septic shock 96.89 31.55 86 12611 84074 90531676
Gastroenteritis norovirus 96.46 31.55 28 12669 2348 90613402
Secondary immunodeficiency 95.02 31.55 27 12670 2099 90613651
Bacteraemia 91.85 31.55 50 12647 22250 90593500
Perineal necrosis 91.07 31.55 16 12681 126 90615624
Pneumatosis intestinalis 90.36 31.55 29 12668 3408 90612342
Lipase increased 88.23 31.55 39 12658 11072 90604678
Hypoalbuminaemia 86.59 31.55 43 12654 15854 90599896
Perineal infection 86.00 31.55 16 12681 179 90615571
Pyomyositis 84.54 31.55 18 12679 415 90615335
Pancytopenia 82.95 31.55 93 12604 120170 90495580
Blood fibrinogen decreased 81.09 31.55 21 12676 1149 90614601
Venous thrombosis 80.46 31.55 30 12667 5507 90610243
Fusarium infection 77.81 31.55 20 12677 1062 90614688
Hypotension 75.87 31.55 151 12546 325246 90290504
Pancreatitis acute 72.58 31.55 49 12648 32066 90583684
Bone marrow failure 72.44 31.55 49 12648 32172 90583578
Hepatic failure 72.10 31.55 53 12644 39675 90576075
Colitis 71.73 31.55 67 12630 69875 90545875
Coagulopathy 71.21 31.55 43 12654 23246 90592504
Multiple organ dysfunction syndrome 69.19 31.55 65 12632 68271 90547479
Potentiating drug interaction 69.06 31.55 27 12670 5635 90610115
Pseudomonal sepsis 68.76 31.55 25 12672 4277 90611473
Fatigue 66.40 31.55 40 12657 1153983 89461767
Antithrombin III decreased 64.33 31.55 13 12684 230 90615520
Thrombocytopenia 63.91 31.55 109 12588 208616 90407134
Alanine aminotransferase increased 62.65 31.55 80 12617 118258 90497492
Pseudomonas test positive 61.35 31.55 16 12681 900 90614850
Blood bilirubin increased 59.34 31.55 49 12648 43421 90572329
Rhinocerebral mucormycosis 58.35 31.55 15 12682 797 90614953
Alopecia 57.11 31.55 3 12694 495068 90120682
Antithrombin III 56.71 31.55 11 12686 156 90615594
Tachycardia 55.90 31.55 88 12609 157585 90458165
Cystitis bacterial 54.02 31.55 12 12685 339 90615411
Enteritis 53.50 31.55 27 12670 10294 90605456
Acute lymphocytic leukaemia recurrent 51.78 31.55 18 12679 2703 90613047
Seizure 51.10 31.55 83 12614 152546 90463204
Arthralgia 50.57 31.55 23 12674 778499 89837251
Clostridium difficile colitis 49.29 31.55 36 12661 26670 90589080
Neutrophil count decreased 48.74 31.55 55 12642 71477 90544273
Device related infection 48.13 31.55 35 12662 25751 90589999
Pulmonary haemorrhage 47.60 31.55 23 12674 7990 90607760
Transverse sinus thrombosis 47.29 31.55 12 12685 605 90615145
Respiratory distress 47.20 31.55 41 12656 38905 90576845
Staphylococcal sepsis 47.04 31.55 24 12673 9359 90606391
Alpha haemolytic streptococcal infection 46.93 31.55 15 12682 1739 90614011
Cerebral venous thrombosis 46.62 31.55 16 12681 2312 90613438
Clostridium test positive 46.26 31.55 20 12677 5381 90610369
Endophthalmitis 45.61 31.55 19 12678 4666 90611084
Neuropathy peripheral 45.19 31.55 74 12623 136896 90478854
Escherichia bacteraemia 45.11 31.55 20 12677 5715 90610035
Anaphylactic reaction 44.47 31.55 58 12639 87466 90528284
Abdominal discomfort 44.22 31.55 7 12690 477321 90138429
Weight increased 43.93 31.55 4 12693 417923 90197827
Pruritus 43.79 31.55 11 12686 541514 90074236
Cholestasis 43.55 31.55 38 12659 36261 90579489
Hepatotoxicity 43.34 31.55 42 12655 45800 90569950
Pain 42.87 31.55 46 12651 996295 89619455
Blood lactic acid increased 42.70 31.55 22 12675 8756 90606994
Rash 42.40 31.55 30 12667 796070 89819680
Disseminated intravascular coagulation 41.95 31.55 30 12667 21508 90594242
Aspergillus infection 41.08 31.55 23 12674 10800 90604950
Blood triglycerides increased 41.01 31.55 25 12672 13736 90602014
Drug ineffective 40.99 31.55 83 12614 1384215 89231535
Fungaemia 40.94 31.55 16 12681 3334 90612416
Respiratory failure 40.45 31.55 65 12632 118353 90497397
Hyperlipidaemia 40.28 31.55 30 12667 22886 90592864
Overgrowth fungal 39.30 31.55 8 12689 147 90615603
Pseudomonas infection 39.24 31.55 25 12672 14840 90600910
Hepatomegaly 39.18 31.55 24 12673 13302 90602448
Respiratory syncytial virus infection 39.04 31.55 22 12675 10458 90605292
Quadriparesis 37.73 31.55 14 12683 2535 90613215
Neutropenic colitis 37.66 31.55 16 12681 4127 90611623
Perirectal abscess 37.55 31.55 11 12686 952 90614798
Trichosporon infection 37.21 31.55 9 12688 372 90615378
Streptococcus test positive 37.19 31.55 12 12685 1433 90614317
Escherichia test positive 37.10 31.55 14 12683 2656 90613094
Cryptococcal fungaemia 35.85 31.55 7 12690 103 90615647
Nasopharyngitis 35.45 31.55 7 12690 407097 90208653
Leukoencephalopathy 35.16 31.55 16 12681 4857 90610893
Pancreatitis necrotising 34.96 31.55 13 12684 2368 90613382
Enterococcal infection 34.60 31.55 20 12677 9971 90605779
Osteonecrosis 34.60 31.55 29 12668 26212 90589538
Staphylococcal bacteraemia 34.27 31.55 18 12679 7451 90608299
Human rhinovirus test positive 33.83 31.55 10 12687 893 90614857
Hyperglycaemic hyperosmolar nonketotic syndrome 33.74 31.55 11 12686 1358 90614392
Bacillus infection 33.24 31.55 10 12687 949 90614801
Intracranial hypotension 32.88 31.55 8 12689 339 90615411
Condition aggravated 32.26 31.55 22 12675 595523 90020227
Ileus 32.11 31.55 23 12674 16523 90599227
Viral infection 31.95 31.55 34 12663 41380 90574370
Enterovirus test positive 31.78 31.55 7 12690 190 90615560
Treatment failure 31.68 31.55 3 12694 303925 90311825
Aplasia 31.65 31.55 14 12683 3977 90611773

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1069.79 21.92 742 15901 184961 42419731
Hypertriglyceridaemia 570.22 21.92 195 16448 9931 42594761
Hypofibrinogenaemia 569.32 21.92 136 16507 1831 42602861
Febrile bone marrow aplasia 406.48 21.92 152 16491 10029 42594663
Hyperbilirubinaemia 314.98 21.92 156 16487 20479 42584213
Mucosal inflammation 215.65 21.92 168 16475 49206 42555486
Myelosuppression 188.30 21.92 143 16500 40318 42564374
Pancreatitis 177.65 21.92 142 16501 43126 42561566
Neutropenia 154.85 21.92 278 16365 199153 42405539
Venoocclusive liver disease 134.11 21.92 70 16573 10232 42594460
Death 111.88 21.92 24 16619 471161 42133531
Coagulopathy 111.21 21.92 82 16561 22080 42582612
Blood fibrinogen decreased 106.50 21.92 35 16608 1568 42603124
Anaphylactic reaction 105.03 21.92 105 16538 42638 42562054
Hepatotoxicity 104.08 21.92 83 16560 25084 42579608
Posterior reversible encephalopathy syndrome 99.12 21.92 62 16581 12759 42591933
Leukoencephalopathy 92.34 21.92 43 16600 4911 42599781
Vomiting 86.81 21.92 279 16364 289444 42315248
Abdominal pain 82.91 21.92 210 16433 190261 42414431
Pancreatitis acute 81.61 21.92 82 16561 33482 42571210
Thrombocytopenia 73.82 21.92 201 16442 190078 42414614
Cerebral venous sinus thrombosis 73.30 21.92 22 16621 729 42603963
Septic shock 72.43 21.92 129 16514 91543 42513149
Hepatopulmonary syndrome 71.09 21.92 15 16628 109 42604583
Sepsis 70.87 21.92 204 16439 199130 42405562
Gallbladder oedema 70.69 21.92 17 16626 235 42604457
Blood bilirubin increased 67.72 21.92 83 16560 42169 42562523
Neurotoxicity 63.47 21.92 61 16582 23590 42581102
Cholestasis 63.37 21.92 71 16572 32808 42571884
Cerebral thrombosis 62.92 21.92 21 16622 987 42603705
Hepatocellular injury 61.53 21.92 60 16583 23618 42581074
Hyperglycaemia 60.80 21.92 82 16561 45777 42558915
Hepatic steatosis 60.76 21.92 57 16586 21391 42583301
Lentigo 58.60 21.92 19 16624 815 42603877
Antithrombin III deficiency 57.30 21.92 13 16630 137 42604555
Superior sagittal sinus thrombosis 55.92 21.92 15 16628 328 42604364
Steatohepatitis 55.25 21.92 16 16627 467 42604225
Aspergillus infection 54.56 21.92 47 16596 15790 42588902
Escherichia infection 54.54 21.92 41 16602 11355 42593337
Potentiating drug interaction 54.36 21.92 33 16610 6435 42598257
Pyrexia 51.48 21.92 295 16348 393747 42210945
Acute lymphocytic leukaemia recurrent 50.67 21.92 26 16617 3665 42601027
Alanine aminotransferase increased 49.86 21.92 108 16535 88298 42516394
Colitis 49.55 21.92 75 16568 46497 42558195
Fibrinous bronchitis 48.47 21.92 11 16632 116 42604576
Product dose omission issue 48.38 21.92 3 16640 154362 42450330
Blood culture positive 48.27 21.92 28 16615 5025 42599667
Cerebral venous thrombosis 46.88 21.92 17 16626 1024 42603668
Lipase increased 46.14 21.92 36 16607 10530 42594162
Enterococcus test positive 45.57 21.92 19 16624 1666 42603026
Bone marrow failure 45.11 21.92 60 16583 33033 42571659
Ascites 45.03 21.92 80 16563 56598 42548094
Bacteraemia 44.73 21.92 52 16591 24988 42579704
Tachycardia 44.43 21.92 112 16531 100975 42503717
Antithrombin III decreased 44.11 21.92 14 16629 560 42604132
Hepatomegaly 42.69 21.92 36 16607 11749 42592943
Fatigue 41.95 21.92 66 16577 435575 42169117
Hypertransaminasaemia 41.51 21.92 32 16611 9195 42595497
Fungal infection 40.43 21.92 44 16599 19678 42585014
Mucormycosis 39.39 21.92 28 16615 7115 42597577
Oesophageal stenosis 38.88 21.92 18 16625 2028 42602664
Candida infection 38.80 21.92 45 16598 21565 42583127
Venoocclusive disease 38.21 21.92 22 16621 3893 42600799
Gastrointestinal wall thickening 37.52 21.92 17 16626 1822 42602870
Pneumonia viral 36.42 21.92 22 16621 4252 42600440
Haemophagocytic lymphohistiocytosis 36.21 21.92 40 16603 18182 42586510
Pneumonia fungal 35.33 21.92 29 16614 9117 42595575
Escherichia sepsis 35.13 21.92 24 16619 5723 42598969
Pseudomonas test positive 34.60 21.92 15 16628 1448 42603244
Parainfluenzae virus infection 34.30 21.92 20 16623 3623 42601069
Dyspnoea 33.86 21.92 77 16566 442544 42162148
Periorbital infection 33.85 21.92 9 16634 190 42604502
Condition aggravated 32.93 21.92 32 16611 260722 42343970
Intussusception 32.71 21.92 12 16631 747 42603945
Respiratory distress 31.89 21.92 58 16585 41762 42562930
Osteonecrosis 31.83 21.92 35 16608 15830 42588862
Drug ineffective 31.63 21.92 133 16510 630064 41974628
Stomatitis 31.28 21.92 64 16579 50265 42554427
Scedosporium infection 30.52 21.92 14 16629 1544 42603148
Escherichia bacteraemia 30.29 21.92 21 16622 5128 42599564
Depression 29.99 21.92 4 16639 111359 42493333
Aplasia 29.07 21.92 20 16623 4823 42599869
Cytomegalovirus hepatitis 28.93 21.92 10 16633 523 42604169
Atypical haemolytic uraemic syndrome 28.47 21.92 10 16633 549 42604143
Insomnia 27.98 21.92 6 16637 118247 42486445
Vascular access complication 27.49 21.92 9 16634 398 42604294
Cytopenia 27.41 21.92 34 16609 17463 42587229
Fall 27.11 21.92 31 16612 234489 42370203
Mucosal infection 27.04 21.92 8 16635 252 42604440
Tumour lysis syndrome 26.81 21.92 38 16605 22193 42582499
Drug clearance decreased 26.07 21.92 14 16629 2164 42602528
Optic nerve disorder 25.89 21.92 10 16633 718 42603974
Peripheral swelling 24.89 21.92 3 16640 90267 42514425
Prothrombin level abnormal 24.68 21.92 6 16637 87 42604605
Brain oedema 24.42 21.92 31 16612 16296 42588396
Multiple lentigines syndrome 24.39 21.92 5 16638 31 42604661
Seizure 24.03 21.92 102 16541 120459 42484233
Acral lentiginous melanoma 23.99 21.92 5 16638 34 42604658
Hypoalbuminaemia 23.92 21.92 30 16613 15580 42589112
Overdose 23.60 21.92 6 16637 105258 42499434
Urinary tract infection 23.56 21.92 5 16638 99279 42505413
Neutropenic colitis 23.45 21.92 17 16626 4453 42600239
Gamma-glutamyltransferase increased 23.43 21.92 44 16599 32453 42572239
Mixed anxiety and depressive disorder 23.20 21.92 7 16636 236 42604456
Hypersensitivity 22.72 21.92 71 16572 72299 42532393
Meningitis bacterial 22.50 21.92 11 16632 1398 42603294

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2265.68 24.34 1252 27407 315515 110245125
Hypertriglyceridaemia 872.95 24.34 273 28386 15881 110544759
Febrile bone marrow aplasia 643.66 24.34 221 28438 17244 110543396
Hypofibrinogenaemia 522.86 24.34 123 28536 2384 110558256
Secondary immunodeficiency 414.58 24.34 116 28543 4560 110556080
Hyperbilirubinaemia 356.02 24.34 169 28490 30502 110530138
Mucosal inflammation 329.37 24.34 240 28419 95901 110464739
Neutropenia 324.09 24.34 440 28219 374180 110186460
Bacterial infection 315.50 24.34 178 28481 45858 110514782
Pancreatitis 294.59 24.34 222 28437 93311 110467329
Human bocavirus infection 281.25 24.34 64 28595 1064 110559576
Myelosuppression 277.51 24.34 215 28444 94125 110466515
Pseudomonal sepsis 251.79 24.34 93 28566 8953 110551687
Rhinovirus infection 238.17 24.34 96 28563 11693 110548947
Mycobacterium chelonae infection 226.69 24.34 66 28593 2994 110557646
Cystitis bacterial 212.33 24.34 52 28607 1201 110559439
Enterobacter infection 208.04 24.34 72 28587 5739 110554901
Posterior reversible encephalopathy syndrome 202.86 24.34 120 28539 33741 110526899
Norovirus test positive 199.15 24.34 47 28612 923 110559717
Thymus hypoplasia 196.97 24.34 52 28607 1635 110559005
Clostridium difficile colitis 196.19 24.34 129 28530 43649 110516991
Human herpesvirus 6 infection 191.81 24.34 70 28589 6511 110554129
Blood culture positive 187.92 24.34 75 28584 8901 110551739
Aspergillus infection 186.21 24.34 103 28556 25513 110535127
Lymphoid tissue hypoplasia 183.36 24.34 49 28610 1616 110559024
Sepsis 181.38 24.34 313 28346 327033 110233607
Viral infection 171.37 24.34 128 28531 53011 110507629
Superior sagittal sinus thrombosis 171.01 24.34 43 28616 1110 110559530
Pneumatosis intestinalis 170.72 24.34 69 28590 8460 110552180
Coagulopathy 167.56 24.34 114 28545 40797 110519843
Venoocclusive liver disease 164.89 24.34 80 28579 15127 110545513
Hepatotoxicity 159.71 24.34 132 28527 63268 110497372
Parainfluenzae virus infection 159.06 24.34 62 28597 6912 110553728
Septic shock 155.90 24.34 198 28461 157330 110403310
Pancreatitis acute 152.89 24.34 126 28533 60148 110500492
Blood fibrinogen decreased 151.91 24.34 47 28612 2628 110558012
Neurotoxicity 150.41 24.34 108 28551 42099 110518541
Thrombocytopenia 139.11 24.34 290 28369 348595 110212045
Bronchopulmonary aspergillosis 136.23 24.34 89 28570 29774 110530866
Hyperglycaemia 131.88 24.34 135 28524 84955 110475685
Pyrexia 131.36 24.34 519 28140 897746 109662894
Enteritis 128.28 24.34 73 28586 19083 110541557
Mucormycosis 127.68 24.34 60 28599 10568 110550072
Viraemia 124.65 24.34 45 28614 4057 110556583
Leukoencephalopathy 120.08 24.34 55 28604 9140 110551500
Bacteraemia 116.76 24.34 93 28566 42297 110518343
Lipase increased 116.62 24.34 68 28591 18604 110542036
Fungal infection 114.02 24.34 99 28560 50707 110509933
Colitis 111.44 24.34 135 28524 102188 110458452
Bone marrow failure 110.64 24.34 103 28556 57745 110502895
Anaphylactic reaction 107.28 24.34 140 28519 114160 110446480
Blood bilirubin increased 106.05 24.34 114 28545 75858 110484782
Fatigue 100.00 24.34 101 28558 1215857 109344783
Acute lymphocytic leukaemia recurrent 96.17 24.34 41 28618 5746 110554894
Intracardiac thrombus 94.00 24.34 37 28622 4231 110556409
Pancytopenia 93.88 24.34 183 28476 209430 110351210
Abscess bacterial 91.11 24.34 25 28634 912 110559728
Antithrombin III decreased 90.24 24.34 22 28637 498 110560142
Cerebral venous sinus thrombosis 88.87 24.34 32 28627 2863 110557777
Cholestasis 88.61 24.34 96 28563 64422 110496218
Pseudomonas test positive 87.49 24.34 30 28629 2324 110558316
Alanine aminotransferase increased 85.41 24.34 163 28496 183610 110377030
Hypoalbuminaemia 82.86 24.34 65 28594 28909 110531731
Hepatocellular injury 79.63 24.34 81 28578 50561 110510079
Venous thrombosis 78.17 24.34 40 28619 8465 110552175
Perineal necrosis 76.68 24.34 16 28643 173 110560467
Tachycardia 75.03 24.34 175 28484 226470 110334170
Hepatomegaly 74.46 24.34 54 28605 21360 110539280
Oral herpes 74.35 24.34 67 28592 36013 110524627
Nasopharyngitis 73.97 24.34 8 28651 394353 110166287
Pain 73.18 24.34 84 28575 954871 109605769
Condition aggravated 72.58 24.34 51 28608 734785 109825855
Seizure 70.19 24.34 168 28491 221017 110339623
Arthralgia 68.34 24.34 61 28598 779571 109781069
Pyomyositis 68.02 24.34 19 28640 741 110559899
Pneumonia fungal 67.35 24.34 44 28615 14710 110545930
Lentigo 67.34 24.34 19 28640 769 110559871
Enterococcus test positive 66.87 24.34 26 28633 2878 110557762
Hepatic failure 65.72 24.34 85 28574 68654 110491986
Device related infection 65.41 24.34 65 28594 39454 110521186
Candida infection 65.16 24.34 71 28588 47938 110512702
Fall 64.88 24.34 38 28621 603444 109957196
Peripheral swelling 64.73 24.34 13 28646 404021 110156619
Alopecia 64.49 24.34 9 28650 364744 110195896
Oesophageal candidiasis 64.19 24.34 39 28620 11495 110549145
Malaise 63.25 24.34 49 28610 671770 109888870
Hepatic steatosis 62.45 24.34 70 28589 48761 110511879
Tumour lysis syndrome 61.12 24.34 56 28603 30745 110529895
Fusarium infection 60.95 24.34 24 28635 2747 110557893
Neutrophil count decreased 60.82 24.34 111 28548 120830 110439810
Pulmonary haemorrhage 60.66 24.34 43 28616 16413 110544227
Multiple organ dysfunction syndrome 60.20 24.34 126 28533 151584 110409056
Cytomegalovirus viraemia 59.96 24.34 44 28615 17720 110542920
Ascites 59.64 24.34 95 28564 92713 110467927
Diffuse alveolar damage 58.53 24.34 26 28633 4021 110556619
Abdominal discomfort 58.44 24.34 15 28644 393843 110166797
Hepatopulmonary syndrome 58.12 24.34 13 28646 199 110560441
Hypotension 58.10 24.34 279 28380 523570 110037070
Gastroenteritis norovirus 58.08 24.34 25 28634 3586 110557054
Escherichia infection 56.66 24.34 48 28611 23768 110536872
Abdominal pain 56.01 24.34 272 28387 512717 110047923
Antithrombin III deficiency 55.69 24.34 12 28647 153 110560487
Cytomegalovirus chorioretinitis 55.49 24.34 30 28629 7098 110553542
Drug ineffective 55.06 24.34 206 28453 1520334 109040306
Coronavirus infection 54.99 24.34 33 28626 9512 110551128
Drug intolerance 53.93 24.34 19 28640 406493 110154147
Cerebral venous thrombosis 53.84 24.34 23 28636 3239 110557401
Muscle spasms 53.82 24.34 5 28654 278152 110282488
Potentiating drug interaction 53.82 24.34 35 28624 11608 110549032
Insomnia 52.98 24.34 14 28645 360576 110200064
Dyspnoea 52.82 24.34 132 28527 1106740 109453900
Aplasia 52.70 24.34 30 28629 7843 110552797
Perineal infection 52.48 24.34 16 28643 851 110559789
Neutropenic colitis 52.02 24.34 30 28629 8035 110552605
Pruritus 51.52 24.34 45 28614 581515 109979125
Osteonecrosis 51.28 24.34 53 28606 33688 110526952
Therapeutic product effect decreased 51.23 24.34 3 28656 244313 110316327
Fibrinous bronchitis 50.71 24.34 11 28648 145 110560495
Venoocclusive disease 50.20 24.34 27 28632 6323 110554317
Cerebral thrombosis 49.66 24.34 20 28639 2428 110558212
Disseminated aspergillosis 49.41 24.34 20 28639 2460 110558180
Staphylococcal bacteraemia 48.93 24.34 38 28621 16650 110543990
Haemophagocytic lymphohistiocytosis 48.74 24.34 50 28609 31509 110529131
Clostridium test positive 48.53 24.34 32 28627 10861 110549779
Respiratory failure 48.45 24.34 144 28515 215188 110345452
Atrial fibrillation 47.60 24.34 3 28656 229639 110331001
Rhinocerebral mucormycosis 47.43 24.34 17 28642 1500 110559140
Dizziness 46.61 24.34 68 28591 698125 109862515
Mucosal infection 46.34 24.34 13 28646 515 110560125
Blood lactic acid increased 46.33 24.34 36 28623 15785 110544855
Respiratory distress 46.32 24.34 72 28587 68802 110491838
Steatohepatitis 46.29 24.34 16 28643 1269 110559371
Wound 45.93 24.34 4 28655 234433 110326207
Disseminated intravascular coagulation 45.78 24.34 55 28604 41231 110519409
Depression 45.34 24.34 13 28646 317322 110243318
Escherichia sepsis 45.34 24.34 30 28629 10242 110550398
Platelet count decreased 45.27 24.34 147 28512 230296 110330344
Pancreatitis necrotising 45.20 24.34 24 28635 5477 110555163
Musculoskeletal stiffness 44.81 24.34 9 28650 279813 110280827
Pseudomonal bacteraemia 44.40 24.34 22 28637 4349 110556291
Herpes simplex 44.28 24.34 35 28624 15729 110544911
Intentional product use issue 44.08 24.34 6 28653 247900 110312740
Urinary tract infection 43.70 24.34 15 28644 326267 110234373
Escherichia bacteraemia 43.21 24.34 29 28630 10135 110550505
Overdose 43.17 24.34 5 28654 233789 110326851
Weight increased 42.87 24.34 28 28631 419616 110141024
Brain oedema 42.21 24.34 46 28613 31052 110529588
Chemotherapeutic drug level increased 41.96 24.34 12 28647 510 110560130
Cytopenia 41.67 24.34 45 28614 30071 110530569
Neuropathy peripheral 41.38 24.34 121 28538 179156 110381484
Vomiting 41.31 24.34 388 28271 910287 109650353
Tachypnoea 41.27 24.34 51 28608 39344 110521296
Oesophageal stenosis 40.94 24.34 22 28637 5143 110555497
Enterovirus infection 40.72 24.34 18 28641 2752 110557888
Dry mouth 40.31 24.34 3 28656 199945 110360695
Fungaemia 40.22 24.34 23 28636 6063 110554577
Rash 39.80 24.34 97 28562 820867 109739773
Hyperammonaemia 39.68 24.34 31 28628 13701 110546939
Escherichia test positive 39.28 24.34 19 28640 3565 110557075
Human rhinovirus test positive 38.98 24.34 14 28645 1243 110559397
Discomfort 38.64 24.34 5 28654 214702 110345938
Cardiac ventricular thrombosis 38.52 24.34 18 28641 3129 110557511
Bacillus test positive 37.88 24.34 9 28650 182 110560458
Swelling 37.83 24.34 22 28637 351019 110209621
Pericarditis 37.34 24.34 6 28653 219108 110341532
Transverse sinus thrombosis 37.24 24.34 12 28647 766 110559874
Enterocolitis infectious 36.97 24.34 18 28641 3426 110557214
Hypertransaminasaemia 36.68 24.34 38 28621 24217 110536423
Death 35.92 24.34 80 28579 698789 109861851
Intussusception 35.51 24.34 14 28645 1607 110559033
Hypophagia 35.36 24.34 55 28604 52571 110508069
Streptococcus test positive 35.28 24.34 16 28643 2598 110558042
Cellulitis 34.97 24.34 91 28568 125925 110434715
Sleep disorder 34.86 24.34 5 28654 198639 110362001
Enterocolitis 34.79 24.34 33 28626 18916 110541724
Overgrowth fungal 34.09 24.34 8 28651 153 110560487
Pseudomonas infection 34.03 24.34 39 28620 27814 110532826
Drug clearance decreased 33.91 24.34 18 28641 4104 110556536
Myocardial infarction 33.32 24.34 5 28654 192078 110368562
Hyperglycaemic hyperosmolar nonketotic syndrome 33.13 24.34 16 28643 2993 110557647
Scedosporium infection 33.03 24.34 15 28644 2443 110558197
Renal replacement therapy 32.45 24.34 8 28651 190 110560450
Arthritis 32.44 24.34 3 28656 167583 110393057
Injury 32.21 24.34 4 28655 177261 110383379
Gamma-glutamyltransferase increased 31.73 24.34 57 28602 61252 110499388
Mobility decreased 31.64 24.34 11 28648 237411 110323229
Stomatococcal infection 31.55 24.34 9 28650 379 110560261
Blister 31.23 24.34 10 28649 227366 110333274
Trichosporon infection 31.21 24.34 12 28647 1288 110559352
Intracranial hypotension 31.19 24.34 10 28649 628 110560012
Pleural effusion 31.03 24.34 109 28550 177600 110383040
Klebsiella infection 29.63 24.34 31 28628 19978 110540662
Staphylococcal sepsis 29.42 24.34 29 28630 17425 110543215
Hepatitis cholestatic 29.26 24.34 29 28630 17537 110543103
Musculoskeletal pain 29.06 24.34 6 28653 183017 110377623
Confusional state 28.99 24.34 48 28611 468632 110092008
Coagulation test abnormal 28.90 24.34 12 28647 1574 110559066
Diarrhoea 28.47 24.34 176 28483 1139329 109421311
Stenotrophomonas infection 28.04 24.34 18 28641 5840 110554800
Perirectal abscess 28.03 24.34 13 28646 2221 110558419
Cytomegalovirus hepatitis 27.75 24.34 10 28649 896 110559744
Type 2 diabetes mellitus 27.75 24.34 6 28653 177226 110383414
Soft tissue infection 27.73 24.34 17 28642 5090 110555550
Hypoxia 27.59 24.34 85 28574 129430 110431210
Apnoea 27.45 24.34 25 28634 13614 110547026
Candida sepsis 27.43 24.34 14 28645 2947 110557693
Enterococcal infection 27.42 24.34 30 28629 20336 110540304
Pulse absent 27.35 24.34 23 28636 11269 110549371
Minimal residual disease 27.26 24.34 10 28649 943 110559697
Antithrombin III 27.13 24.34 6 28653 87 110560553
General physical health deterioration 26.82 24.34 43 28616 425252 110135388
Anorectal cellulitis 26.52 24.34 6 28653 97 110560543
Vascular access complication 26.50 24.34 13 28646 2515 110558125
Mental status changes 26.50 24.34 60 28599 76062 110484578
Memory impairment 26.45 24.34 9 28650 196935 110363705
Hypogonadism 26.26 24.34 12 28647 1982 110558658
Contusion 26.03 24.34 14 28645 233347 110327293
Hepatic enzyme increased 25.84 24.34 27 28632 320865 110239775
Peripheral motor neuropathy 25.83 24.34 15 28644 4071 110556569
Pulmonary mucormycosis 25.43 24.34 12 28647 2131 110558509
Device related thrombosis 25.37 24.34 14 28645 3448 110557192
Product use issue 25.36 24.34 26 28633 311669 110248971
Unresponsive to stimuli 25.30 24.34 53 28606 63737 110496903
Cholangitis infective 24.73 24.34 9 28650 830 110559810
Anxiety 24.60 24.34 32 28627 345046 110215594
Lung disorder 24.58 24.34 8 28651 180039 110380601
Cryptococcal fungaemia 24.47 24.34 7 28652 298 110560342
Acral lentiginous melanoma 24.41 24.34 5 28654 49 110560591

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XX24 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
FDA CS M0001815 Asparaginase
MeSH PA D000970 Antineoplastic Agents
FDA EPC N0000175669 Asparagine-specific Enzyme
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent

Related Drugs by ATC class:

L01XX Other antineoplastic agents 33 drugs
adagrasibafliberceptaltretamineamsacrineanagrelidearsenic trioxideasparaginasebelzutifancalaspargase pegolcelecoxibdarinaparsindenileukin diftitox show all 33 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Malignant lymphoma indication 118600007 DOID:0060058




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
7D96IR0PPM UNII
D05387 KEGG_DRUG
4020867 VANDF
C0071568 UMLSCUI
CHEBI:753505 CHEBI
CHEMBL2108546 ChEMBL_ID
DB00059 DRUGBANK_ID
6665 INN_ID
C042705 MESH_SUPPLEMENTAL_RECORD_UI
224911 RXNORM
11316 MMSL
5239 MMSL
d04247 MMSL
004476 NDDF
108814000 SNOMEDCT_US
416337002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ONCASPAR HUMAN PRESCRIPTION DRUG LABEL 1 72694-954 INJECTION, SOLUTION 750 [iU] INTRAVENOUS BLA 31 sections