necitumumab Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
human origin 5071 906805-06-9

Description:

MoleculeDescription

Synonyms:

  • necitumumab
  • portrazza
  • IMC-11F8
a fully human antibody that has similar antitumor potency as the chimeric cetuximab/Erbitux and might represent a safer therapeutic alternative in EGF receptor inhibition
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 15, 2016 EMA Eli Lilly Nederland B.V.
Nov. 24, 2015 FDA ELI LILLY CO

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XC22 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Monoclonal antibodies
FDA MoA N0000020010 HER1 Antagonists
FDA EPC N0000175664 Epidermal Growth Factor Receptor Antagonist
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Non-small cell lung cancer indication 254637007 DOID:3908

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Epidermal growth factor receptor Kinase ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
4035252 VANDF
C4049052 UMLSCUI
CHEMBL1743047 ChEMBL_ID
DB09559 DRUGBANK_ID
C527969 MESH_SUPPLEMENTAL_RECORD_UI
8090 IUPHAR_LIGAND_ID
9083 INN_ID
2BT4C47RUI UNII
1723738 RXNORM
237238 MMSL
31299 MMSL
d08400 MMSL
016603 NDDF
716015005 SNOMEDCT_US
781320006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Portrazza HUMAN PRESCRIPTION DRUG LABEL 1 0002-7716 SOLUTION 16 mg INTRAVENOUS BLA 24 sections