necitumumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	5071	906805-06-9

Description:

Molecule

Description

Synonyms:

necitumumab
portrazza
IMC-11F8

a fully human antibody that has similar antitumor potency as the chimeric cetuximab/Erbitux and might represent a safer therapeutic alternative in EGF receptor inhibition

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 15, 2016	EMA	Eli Lilly Nederland B.V.
Nov. 24, 2015	FDA	ELI LILLY CO
June 18, 2019	PMDA	ELI LILLY JAPAN K.K.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01FE03	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES EGFR (Epidermal Growth Factor Receptor) inhibitors
FDA MoA	N0000020010	HER1 Antagonists
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000074322	Antineoplastic Agents, Immunological
FDA EPC	N0000175664	Epidermal Growth Factor Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Non-small cell lung cancer	indication	254637007	DOID:3908
Squamous non-small cell lung cancer	indication	723301009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN	ANTIBODY BINDING	Kd	9.49		IUPHAR	DRUG LABEL

External reference:

ID	Source
2BT4C47RUI	UNII
4035252	VANDF
C2352806	UMLSCUI
CHEMBL1743047	ChEMBL_ID
DB09559	DRUGBANK_ID
9083	INN_ID
C527969	MESH_SUPPLEMENTAL_RECORD_UI
8090	IUPHAR_LIGAND_ID
1723738	RXNORM
237238	MMSL
31299	MMSL
d08400	MMSL
016603	NDDF
716015005	SNOMEDCT_US
781320006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Portrazza	HUMAN PRESCRIPTION DRUG LABEL	1	0002-7716	SOLUTION	16 mg	INTRAVENOUS	BLA	24 sections