All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

collagenase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5051	9001-12-1

Description:

Molecule	Description
Synonyms: collagenase xiaflex collagenase clostridium histolyticum	purified collagenase clostridium histolyticum, consisting of two microbial collagenases in a defined mass ratio, Collagenase AUX-I and Collagenase AUX-II, which are isolated and purified from the fermentation of Clostridium histolyticum bacteria Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.90	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 4, 1965	FDA	ADVANCE BIOFACTURES

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	143.82	25.88	89	1350	456462	90170546
Tendon rupture	93.58	25.88	23	1416	9220	90617788
Contusion	78.61	25.88	49	1390	251167	90375841
Blood blister	52.08	25.88	11	1428	2244	90624764
Wound complication	48.93	25.88	12	1427	4751	90622257
Skin laceration	42.99	25.88	16	1423	26019	90600989
Axillary pain	40.55	25.88	9	1430	2312	90624696
Pain in extremity	32.95	25.88	38	1401	450491	90176517
Ecchymosis	29.57	25.88	10	1429	12313	90614695
Oedema peripheral	28.20	25.88	27	1412	257888	90369120
Injection site pain	26.57	25.88	22	1417	173677	90453331

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fracture of penis	1747.87	43.12	222	3800	117	42617196
Penile swelling	811.48	43.12	130	3892	873	42616440
Corpora cavernosa surgery	759.81	43.12	95	3927	31	42617282
Penile haematoma	718.97	43.12	98	3924	154	42617159
Penile contusion	698.85	43.12	93	3929	107	42617206
Penile pain	451.20	43.12	86	3936	1702	42615611
Contusion	358.19	43.12	138	3884	41847	42575466
Drug ineffective	302.64	43.12	329	3693	629868	41987445
Skin laceration	258.32	43.12	82	3940	13976	42603337
Swelling	202.36	43.12	100	3922	54785	42562528
Penis disorder	165.33	43.12	36	3986	1397	42615916
Penile haemorrhage	153.47	43.12	32	3990	1006	42616307
Penile blister	135.57	43.12	20	4002	69	42617244
Genital contusion	132.33	43.12	16	4006	0	42617313
Injection site swelling	130.89	43.12	52	3970	16921	42600392
Injection site pain	130.29	43.12	76	3946	57722	42559591
Inappropriate schedule of product administration	126.61	43.12	90	3932	95812	42521501
Blood blister	109.84	43.12	28	3994	2155	42615158
Injection site bruising	101.87	43.12	39	3983	11486	42605827
Skin graft	75.66	43.12	16	4006	538	42616775
Spontaneous penile erection	73.28	43.12	14	4008	278	42617035
Haematoma	71.48	43.12	40	3982	27983	42589330
Ecchymosis	71.25	43.12	27	3995	7725	42609588
Painful erection	70.71	43.12	14	4008	337	42616976
Injection site haematoma	69.58	43.12	19	4003	1906	42615407
Wrong technique in product usage process	60.72	43.12	42	3980	42593	42574720
Penile size reduced	58.34	43.12	11	4011	203	42617110
Penile oedema	49.16	43.12	11	4011	483	42616830
Penis injury	44.21	43.12	9	4013	250	42617063

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fracture of penis	1024.83	30.71	119	3855	106	110585219
Penile swelling	765.20	30.71	106	3868	700	110584625
Penile haematoma	614.22	30.71	74	3900	116	110585209
Corpora cavernosa surgery	511.15	30.71	58	3916	31	110585294
Penile contusion	509.97	30.71	60	3914	66	110585259
Penile pain	404.79	30.71	64	3910	1120	110584205
Skin laceration	215.70	30.71	70	3904	33683	110551642
Contusion	206.60	30.71	119	3855	233242	110352083
Death	167.51	30.71	162	3812	698707	109886618
Penis disorder	144.54	30.71	26	3948	1004	110584321
Penile haemorrhage	141.15	30.71	25	3949	883	110584442
Blood blister	110.30	30.71	26	3948	3833	110581492
Injection site pain	106.85	30.71	71	3903	177851	110407474
Genital contusion	101.59	30.71	11	3963	0	110585325
Inappropriate schedule of product administration	95.89	30.71	70	3904	203567	110381758
Drug ineffective	94.96	30.71	183	3791	1520357	109064968
Tendon rupture	84.98	30.71	28	3946	14050	110571275
Penile blister	72.75	30.71	10	3964	61	110585264
Injection site swelling	72.30	30.71	38	3936	61752	110523573
Ecchymosis	71.72	30.71	26	3948	17312	110568013
Axillary pain	66.50	30.71	16	3958	2570	110582755
Skin graft	62.28	30.71	13	3961	1098	110584227
Injection site bruising	61.31	30.71	32	3942	51231	110534094
Injection site haematoma	60.08	30.71	17	3957	5129	110580196
Painful erection	53.46	30.71	9	3965	234	110585091
Spontaneous penile erection	48.67	30.71	8	3966	179	110585146
Swelling	46.47	30.71	60	3914	350981	110234344
Penile oedema	44.33	30.71	8	3966	314	110585011
Wound complication	44.27	30.71	14	3960	6163	110579162
Pain in extremity	39.40	30.71	66	3908	487052	110098273
Oedema peripheral	35.61	30.71	51	3923	328609	110256716
Erectile dysfunction	32.39	30.71	15	3959	18541	110566784
Haematoma	31.82	30.71	22	3952	58454	110526871
Penile size reduced	31.25	30.71	5	3969	94	110585231

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D03BA02	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS ENZYMES Proteolytic enzymes
ATC	D03BA52	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS ENZYMES Proteolytic enzymes
ATC	M09AB02	MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM Enzymes
FDA Chemical/Ingredient	N0000006395	Collagenases
FDA EPC	N0000175843	Collagen-specific Enzyme
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent

Related Drugs by ATC class:

D03BA Proteolytic enzymes 1 drug

trypsin

M09AB Enzymes 2 drugs

chymopapaintrypsin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Induratio penis plastica	indication	1335005	DOID:8616
Dupuytren's disease of finger, with contracture	indication	203051006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D09596	KEGG_DRUG
4018477	VUID
N0000146799	NUI
4018477	VANDF
4029767	VANDF
C0162745	UMLSCUI
CHEMBL2108709	ChEMBL_ID
75007581	PUBCHEM_CID
DB00048	DRUGBANK_ID
58939	RXNORM
170479	MMSL
26980	MMSL
4497	MMSL
72861	MMSL
d07548	MMSL
001890	NDDF
417416003	SNOMEDCT_US
56355009	SNOMEDCT_US
772213007	SNOMEDCT_US
786084006	SNOMEDCT_US
CHEBI:753652	CHEBI
9X7O8V25IT	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
COLLAGENASE SANTYL	HUMAN PRESCRIPTION DRUG LABEL	1	50484-010	OINTMENT	250 [arbU]	TOPICAL	BLA	10 sections
Kimchi Vitaminchewable multivitamin	HUMAN OTC DRUG LABEL	11	52102-1001	TABLET, CHEWABLE	5.63 mg	ORAL	unapproved drug other	2 sections
Bio-Collagen Real Deep Mask	HUMAN OTC DRUG LABEL	1	84732-076	PATCH	1 mg	CUTANEOUS	OTC Monograph Drug	9 sections
NOAVIA Retinol Moisturizer	HUMAN OTC DRUG LABEL	6	85212-0011	CREAM	0.50 g	EXTRACORPOREAL	OTC Monograph Drug	11 sections