collagenase Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5051 9001-12-1

Description:

MoleculeDescription

Synonyms:

  • collagenase
  • xiaflex
  • collagenase clostridium histolyticum
purified collagenase clostridium histolyticum, consisting of two microbial collagenases in a defined mass ratio, Collagenase AUX-I and Collagenase AUX-II, which are isolated and purified from the fermentation of Clostridium histolyticum bacteria
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.90 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 4, 1965 FDA ADVANCE BIOFACTURES

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Contusion 101.10 31.26 42 747 87445 46597828
Tendon rupture 80.93 31.26 20 769 7739 46677534
Blood blister 54.74 31.26 11 778 1657 46683616
Skin laceration 39.66 31.26 14 775 18488 46666785
Axillary pain 39.16 31.26 8 781 1305 46683968
Wound complication 38.79 31.26 9 780 2651 46682622
Oedema peripheral 38.26 31.26 27 762 159679 46525594
Pain in extremity 32.58 31.26 30 759 258650 46426623

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fracture of penis 937.56 50.89 121 2746 84 29949527
Penile swelling 753.11 50.89 119 2748 715 29948896
Penile contusion 649.24 50.89 87 2780 108 29949503
Penile haematoma 621.74 50.89 84 2783 116 29949495
Corpora cavernosa surgery 490.03 50.89 62 2805 27 29949584
Penile pain 399.35 50.89 75 2792 1350 29948261
Drug ineffective 290.04 50.89 245 2622 340142 29609469
Skin laceration 258.16 50.89 78 2789 11173 29938438
Contusion 244.93 50.89 97 2770 31183 29918428
Injection site pain 159.74 50.89 71 2796 30239 29919372
Penis disorder 156.02 50.89 33 2834 1099 29948512
Injection site swelling 151.47 50.89 49 2818 8731 29940880
Swelling 133.04 50.89 66 2801 35909 29913702
Penile haemorrhage 132.62 50.89 26 2841 587 29949024
Genital contusion 132.11 50.89 16 2851 0 29949611
Blood blister 114.90 50.89 27 2840 1460 29948151
Penile blister 110.60 50.89 17 2850 81 29949530
Inappropriate schedule of product administration 107.11 50.89 59 2808 39669 29909942
Injection site bruising 106.65 50.89 36 2831 7302 29942309
Skin graft 75.00 50.89 16 2851 554 29949057
Injection site haematoma 68.96 50.89 18 2849 1499 29948112
Penile size reduced 53.19 50.89 10 2857 179 29949432
Wrong technique in product usage process 51.90 50.89 34 2833 31121 29918490
Painful erection 51.27 50.89 10 2857 219 29949392

Pharmacologic Action:

SourceCodeDescription
ATC D03BA02 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
ENZYMES
Proteolytic enzymes
ATC D03BA52 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
ENZYMES
Proteolytic enzymes
ATC M09AB02 MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
Enzymes
FDA Chemical/Ingredient N0000006395 Collagenases
FDA EPC N0000175843 Collagen-specific Enzyme

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Induratio penis plastica indication 1335005 DOID:8616
Dupuytren's disease of finger, with contracture indication 203051006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
collagen Metabolite HYDROLYTIC ENZYME DRUG LABEL DRUG LABEL

External reference:

IDSource
D09596 KEGG_DRUG
4018477 VUID
N0000146799 NUI
4018477 VANDF
4029767 VANDF
C0162745 UMLSCUI
CHEMBL2108709 ChEMBL_ID
DB00048 DRUGBANK_ID
9X7O8V25IT UNII
58939 RXNORM
170479 MMSL
26980 MMSL
4497 MMSL
72861 MMSL
d07548 MMSL
001890 NDDF
417416003 SNOMEDCT_US
56355009 SNOMEDCT_US
772213007 SNOMEDCT_US
786084006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COLLAGENULLSE SANTYL HUMAN PRESCRIPTION DRUG LABEL 1 50484-010 OINTMENT 250 [arbU] TOPICAL BLA 10 sections
Kimchi Vitaminchewable multivitamin HUMAN OTC DRUG LABEL 11 52102-1001 TABLET, CHEWABLE 5.63 mg ORAL unapproved drug other 2 sections
Qwo HUMAN PRESCRIPTION DRUG LABEL 1 73611-300 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 0.23 mg INTRALESIONULLL BLA 27 sections