collagenase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5051 9001-12-1

Description:

MoleculeDescription

Synonyms:

  • collagenase
  • xiaflex
  • collagenase clostridium histolyticum
purified collagenase clostridium histolyticum, consisting of two microbial collagenases in a defined mass ratio, Collagenase AUX-I and Collagenase AUX-II, which are isolated and purified from the fermentation of Clostridium histolyticum bacteria
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.90 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 4, 1965 FDA ADVANCE BIOFACTURES

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 143.82 25.88 89 1350 456462 90170546
Tendon rupture 93.58 25.88 23 1416 9220 90617788
Contusion 78.61 25.88 49 1390 251167 90375841
Blood blister 52.08 25.88 11 1428 2244 90624764
Wound complication 48.93 25.88 12 1427 4751 90622257
Skin laceration 42.99 25.88 16 1423 26019 90600989
Axillary pain 40.55 25.88 9 1430 2312 90624696
Pain in extremity 32.95 25.88 38 1401 450491 90176517
Ecchymosis 29.57 25.88 10 1429 12313 90614695
Oedema peripheral 28.20 25.88 27 1412 257888 90369120
Injection site pain 26.57 25.88 22 1417 173677 90453331

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fracture of penis 1747.87 43.12 222 3800 117 42617196
Penile swelling 811.48 43.12 130 3892 873 42616440
Corpora cavernosa surgery 759.81 43.12 95 3927 31 42617282
Penile haematoma 718.97 43.12 98 3924 154 42617159
Penile contusion 698.85 43.12 93 3929 107 42617206
Penile pain 451.20 43.12 86 3936 1702 42615611
Contusion 358.19 43.12 138 3884 41847 42575466
Drug ineffective 302.64 43.12 329 3693 629868 41987445
Skin laceration 258.32 43.12 82 3940 13976 42603337
Swelling 202.36 43.12 100 3922 54785 42562528
Penis disorder 165.33 43.12 36 3986 1397 42615916
Penile haemorrhage 153.47 43.12 32 3990 1006 42616307
Penile blister 135.57 43.12 20 4002 69 42617244
Genital contusion 132.33 43.12 16 4006 0 42617313
Injection site swelling 130.89 43.12 52 3970 16921 42600392
Injection site pain 130.29 43.12 76 3946 57722 42559591
Inappropriate schedule of product administration 126.61 43.12 90 3932 95812 42521501
Blood blister 109.84 43.12 28 3994 2155 42615158
Injection site bruising 101.87 43.12 39 3983 11486 42605827
Skin graft 75.66 43.12 16 4006 538 42616775
Spontaneous penile erection 73.28 43.12 14 4008 278 42617035
Haematoma 71.48 43.12 40 3982 27983 42589330
Ecchymosis 71.25 43.12 27 3995 7725 42609588
Painful erection 70.71 43.12 14 4008 337 42616976
Injection site haematoma 69.58 43.12 19 4003 1906 42615407
Wrong technique in product usage process 60.72 43.12 42 3980 42593 42574720
Penile size reduced 58.34 43.12 11 4011 203 42617110
Penile oedema 49.16 43.12 11 4011 483 42616830
Penis injury 44.21 43.12 9 4013 250 42617063

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fracture of penis 1024.83 30.71 119 3855 106 110585219
Penile swelling 765.20 30.71 106 3868 700 110584625
Penile haematoma 614.22 30.71 74 3900 116 110585209
Corpora cavernosa surgery 511.15 30.71 58 3916 31 110585294
Penile contusion 509.97 30.71 60 3914 66 110585259
Penile pain 404.79 30.71 64 3910 1120 110584205
Skin laceration 215.70 30.71 70 3904 33683 110551642
Contusion 206.60 30.71 119 3855 233242 110352083
Death 167.51 30.71 162 3812 698707 109886618
Penis disorder 144.54 30.71 26 3948 1004 110584321
Penile haemorrhage 141.15 30.71 25 3949 883 110584442
Blood blister 110.30 30.71 26 3948 3833 110581492
Injection site pain 106.85 30.71 71 3903 177851 110407474
Genital contusion 101.59 30.71 11 3963 0 110585325
Inappropriate schedule of product administration 95.89 30.71 70 3904 203567 110381758
Drug ineffective 94.96 30.71 183 3791 1520357 109064968
Tendon rupture 84.98 30.71 28 3946 14050 110571275
Penile blister 72.75 30.71 10 3964 61 110585264
Injection site swelling 72.30 30.71 38 3936 61752 110523573
Ecchymosis 71.72 30.71 26 3948 17312 110568013
Axillary pain 66.50 30.71 16 3958 2570 110582755
Skin graft 62.28 30.71 13 3961 1098 110584227
Injection site bruising 61.31 30.71 32 3942 51231 110534094
Injection site haematoma 60.08 30.71 17 3957 5129 110580196
Painful erection 53.46 30.71 9 3965 234 110585091
Spontaneous penile erection 48.67 30.71 8 3966 179 110585146
Swelling 46.47 30.71 60 3914 350981 110234344
Penile oedema 44.33 30.71 8 3966 314 110585011
Wound complication 44.27 30.71 14 3960 6163 110579162
Pain in extremity 39.40 30.71 66 3908 487052 110098273
Oedema peripheral 35.61 30.71 51 3923 328609 110256716
Erectile dysfunction 32.39 30.71 15 3959 18541 110566784
Haematoma 31.82 30.71 22 3952 58454 110526871
Penile size reduced 31.25 30.71 5 3969 94 110585231

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D03BA02 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
ENZYMES
Proteolytic enzymes
ATC D03BA52 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
ENZYMES
Proteolytic enzymes
ATC M09AB02 MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
Enzymes
FDA Chemical/Ingredient N0000006395 Collagenases
FDA EPC N0000175843 Collagen-specific Enzyme
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:67079 anti-inflammatory agent

Related Drugs by ATC class:

D03BA Proteolytic enzymes 1 drug
trypsin
M09AB Enzymes 2 drugs
chymopapaintrypsin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Induratio penis plastica indication 1335005 DOID:8616
Dupuytren's disease of finger, with contracture indication 203051006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D09596 KEGG_DRUG
4018477 VUID
N0000146799 NUI
4018477 VANDF
4029767 VANDF
C0162745 UMLSCUI
CHEMBL2108709 ChEMBL_ID
75007581 PUBCHEM_CID
DB00048 DRUGBANK_ID
58939 RXNORM
170479 MMSL
26980 MMSL
4497 MMSL
72861 MMSL
d07548 MMSL
001890 NDDF
417416003 SNOMEDCT_US
56355009 SNOMEDCT_US
772213007 SNOMEDCT_US
786084006 SNOMEDCT_US
CHEBI:753652 CHEBI
9X7O8V25IT UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COLLAGENASE SANTYL HUMAN PRESCRIPTION DRUG LABEL 1 50484-010 OINTMENT 250 [arbU] TOPICAL BLA 10 sections
Kimchi Vitaminchewable multivitamin HUMAN OTC DRUG LABEL 11 52102-1001 TABLET, CHEWABLE 5.63 mg ORAL unapproved drug other 2 sections
Bio-Collagen Real Deep Mask HUMAN OTC DRUG LABEL 1 84732-076 PATCH 1 mg CUTANEOUS OTC Monograph Drug 9 sections
NOAVIA Retinol Moisturizer HUMAN OTC DRUG LABEL 6 85212-0011 CREAM 0.50 g EXTRACORPOREAL OTC Monograph Drug 11 sections