Molfile
Inchi
Smiles
Synonyms:
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HBS-101
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pitolisant
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tiprolisant
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pitolisant hydrochloride
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tiprolisant hydrochloride
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wakix
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BF2.649
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Pitolisant is a potent, orally active histamine H3-receptor antagonist/inverse agonist which, via its blockade of histamine auto-receptors enhances the activity of brain histaminergic neurons, a major arousal system with widespread projections to the whole brain. Pitolisant also modulates various neurotransmitter systems, increasing acetylcholine, noradrenaline and dopamine release in the brain.
- Molecular weight: 295.85
- Formula: C17H26ClNO
- CLOGP: 4.82
- LIPINSKI: 0
- HAC: 2
- HDO: 0
- TPSA: 12.47
- ALOGS: -5.32
- ROTB: 8
- Status: ONP
Legend: OFP - off patent OFM - off market ONP - on patent
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