saroglitazar 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| dual peroxisome proliferator activated receptors-alpha and gamma(PPAR-alpha,gamma) agonists | 5047 | 495399-09-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a PPARalpha and PPARgamma agonist
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 26, 2013 | CDSCO (INDIA) | CADILA HEALTHCARE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35526 | antidiabetic |
| CHEBI has role | CHEBI:70782 | PPAR-alpha agonist |
| CHEBI has role | CHEBI:71554 | PPARgamma agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetic dyslipidemia associated with type 2 diabetes mellitus | indication | 761000119102 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.58 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor alpha | Nuclear hormone receptor | AGONIST | EC50 | 9.19 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | AGONIST | EC50 | 8.52 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| E0YMX3S4JD | UNII |
| 1639792-20-3 | SECONDARY_CAS_RN |
| C3852920 | UMLSCUI |
| CHEBI:134708 | CHEBI |
| EWR | PDB_CHEM_ID |
| CHEMBL4297530 | ChEMBL_ID |
| 60151560 | PUBCHEM_CID |
| DB13115 | DRUGBANK_ID |
| 9677 | INN_ID |
| C000588741 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1163258006 | SNOMEDCT_US |
| 1172675002 | SNOMEDCT_US |
Pharmaceutical products:
None