DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
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L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
mogamulizumab 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
humanized origin
5031
1159266-37-1
Description:
Molecule
Description
Synonyms:
mogamulizumab-kpkc
AMG-761
KM8761
mogamulizumab
mogamulizumab (genetical recombination)
poteligeo
KW-0761
a defucosylated humanized anti-CCR4 antibody under phase I clinical trials (2010)
Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Aug. 8, 2018
FDA
KYOWA KIRIN
March 30, 2012
PMDA
Kyowa Hakko Kirin Co., Ltd.
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1
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Diffuse large B-cell lymphoma
59.60
58.97
13
226
7357
34949335
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Diffuse large B-cell lymphoma
55.74
50.22
13
427
12136
79731812
Peripheral T-cell lymphoma unspecified stage III
51.19
50.22
5
435
7
79743941
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
L01FX09
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
Other monoclonal antibodies and antibody drug conjugates
FDA CS
M0001357
Antibodies, Monoclonal
FDA EPC
N0000193863
Monoclonal Antibody
FDA EPC
N0000193866
Chemokine Receptor Type 4 Interaction
FDA MoA
N0000193867
Chemokine Receptor Type 4 Interactions
MeSH PA
D000970
Antineoplastic Agents
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Peripheral T-cell lymphoma
indication
109977009
Mycosis fungoides
indication
118618005
Primary cutaneous T-cell lymphoma
indication
400122007
Showing 1 to 3 of 3 entries
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
C-C chemokine receptor type 4
GPCR
P51679
CCR4_HUMAN
ANTIBODY BINDING
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Showing 1 to 1 of 1 entries
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External reference:
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100
entries
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ID
Source
017677
NDDF
2054068
RXNORM
287441
MMSL
34735
MMSL
34736
MMSL
4037780
VANDF
4037781
VANDF
6477
IUPHAR_LIGAND_ID
773521007
SNOMEDCT_US
773522000
SNOMEDCT_US
Showing 1 to 10 of 18 entries
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
POTELIGEO
HUMAN PRESCRIPTION DRUG LABEL
1
42747-761
INJECTION
4 mg
INTRAVENOUS
BLA
27 sections
POTELIGEO
HUMAN PRESCRIPTION DRUG LABEL
1
42747-761
INJECTION
4 mg
INTRAVENOUS
BLA
27 sections
POTELIGEO
HUMAN PRESCRIPTION DRUG LABEL
1
42747-761
INJECTION
4 mg
INTRAVENOUS
BLA
27 sections
Showing 1 to 3 of 3 entries
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Structure 🔎
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L1000
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mogamulizumab