ocriplasmin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5004 1048016-09-6

Description:

MoleculeDescription

Synonyms:

  • ocriplasmin
  • microplasmin
  • ocriplasmine
  • jetrea
  • ocriplasmin (genetical recombination)
consists or two polypeptide chains connected by disulfide bonds; one chain is the B chain of plasmin consisting of 230 amino acids, the other peptide is the COOH-terminal portion of the A chain of plasmin consisting of 31 amino acid residues; MW 28.635kDa
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 13, 2013 EMA
Oct. 17, 2012 FDA THROMBOGENICS, INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Photopsia 388.88 316.08 62 576 4447 63483937

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Photopsia 398.83 299.93 63 586 5273 79738466

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01XA22 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA CS M0016225 Peptide Hydrolases
FDA EPC N0000191621 Proteolytic Enzyme

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vitreomacular traction syndrome indication 312901001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D09646 KEGG_DRUG
4032029 VUID
N0000186140 NUI
4032029 VANDF
CHEMBL2095222 ChEMBL_ID
C054561 MESH_SUPPLEMENTAL_RECORD_UI
7446 IUPHAR_LIGAND_ID
DB08888 DRUGBANK_ID
1315214 RXNORM
194281 MMSL
28944 MMSL
014688 NDDF
710290003 SNOMEDCT_US
715493002 SNOMEDCT_US
C0066522 UMLSCUI
9178 INN_ID
7V6HE3DM5A UNII

Pharmaceutical products:

None