All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

epoetin alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
erythropoietin type blood factors	4995	113427-24-0

Description:

Molecule	Description
Synonyms: epoetin alfa-epbx epoetin alfa epogen procrit epoetin alfa (genetical recombination) erythropoietin	Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
1	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 1, 1989	FDA	AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplasia pure red cell	726.37	11.79	218	40970	4269	63443565
Haemoglobin decreased	633.48	11.79	614	40574	144871	63302963
Death	523.06	11.79	897	40291	373484	63074350
Nephrogenic systemic fibrosis	481.89	11.79	160	41028	4396	63443438
Product storage error	344.10	11.79	176	41012	14780	63433054
Anaemia	341.18	11.79	650	40538	292780	63155054
Therapeutic response decreased	271.50	11.79	262	40926	61263	63386571
Anti-erythropoietin antibody positive	222.13	11.79	52	41136	362	63447472
Peritonitis bacterial	191.37	11.79	83	41105	4796	63443038
Haemoglobin abnormal	181.60	11.79	81	41107	5007	63442827
Skin induration	181.43	11.79	71	41117	3152	63444682
Anti-erythropoietin antibody negative	175.56	11.79	35	41153	97	63447737
Shunt stenosis	149.88	11.79	40	41148	500	63447334
Skin hypertrophy	143.91	11.79	61	41127	3330	63444504
Thrombocytopenia	137.40	11.79	303	40885	150854	63296980
Drug ineffective	121.49	11.79	317	40871	1044448	62403386
Skin tightness	111.61	11.79	55	41133	4261	63443573
Drug intolerance	109.91	11.79	32	41156	308629	63139205
Haematocrit decreased	107.30	11.79	130	41058	39210	63408624
Peritonitis	107.24	11.79	89	41099	17065	63430769
Rheumatoid arthritis	107.08	11.79	18	41170	253801	63194033
Pancytopenia	102.76	11.79	207	40981	96726	63351108
Peritoneal dialysis complication	98.43	11.79	35	41153	1185	63446649
Contraindicated product administered	97.39	11.79	13	41175	217635	63230199
Arthropathy	93.99	11.79	19	41169	234773	63213061
Synovitis	91.67	11.79	8	41180	186910	63260924
Sepsis	90.78	11.79	261	40927	152862	63294972
Fibrosis	89.68	11.79	47	41141	4145	63443689
Glossodynia	89.53	11.79	7	41181	178869	63268965
Renal failure	89.47	11.79	220	40968	117432	63330402
Myelodysplastic syndrome	88.62	11.79	79	41109	16675	63431159
Joint swelling	86.27	11.79	53	41135	327613	63120221
Skin fibrosis	85.49	11.79	29	41159	851	63446983
Plasma cell myeloma	84.14	11.79	110	41078	35795	63412039
Hospitalisation	82.30	11.79	175	41013	84906	63362928
Platelet count decreased	81.87	11.79	211	40977	115911	63331923
Hyperparathyroidism	80.04	11.79	38	41150	2711	63445123
Systemic lupus erythematosus	79.37	11.79	19	41169	208899	63238935
Reticulocyte count decreased	76.79	11.79	23	41165	446	63447388
Treatment failure	75.81	11.79	18	41170	199025	63248809
Cardio-respiratory arrest	75.77	11.79	138	41050	59821	63388013
Asthenia	75.13	11.79	465	40723	383139	63064695
Abdominal discomfort	71.34	11.79	62	41126	320823	63127011
Oedema peripheral	71.24	11.79	277	40911	189234	63258600
Product use issue	69.55	11.79	28	41160	220492	63227342
Therapeutic product effect decreased	68.76	11.79	20	41168	193167	63254667
Hepatic enzyme increased	68.34	11.79	23	41165	202305	63245529
Sinusitis	67.95	11.79	31	41157	226622	63221212
Dialysis	67.05	11.79	55	41133	10372	63437462
Arteriovenous fistula site complication	66.38	11.79	21	41167	492	63447342
Drug hypersensitivity	65.53	11.79	63	41125	310624	63137210
Infusion related reaction	64.18	11.79	40	41148	245481	63202353
Alopecia	61.74	11.79	77	41111	337459	63110375
Calciphylaxis	61.63	11.79	33	41155	3039	63444795
Hypervolaemia	60.38	11.79	83	41105	28330	63419504
Headache	59.05	11.79	212	40976	633029	62814805
Haematocrit abnormal	58.74	11.79	22	41166	865	63446969
Diffuse large B-cell lymphoma refractory	58.50	11.79	24	41164	1206	63446628
Refractory cytopenia with unilineage dysplasia	56.82	11.79	19	41169	533	63447301
Pericarditis	56.19	11.79	9	41179	131570	63316264
Renal transplant	55.83	11.79	24	41164	1356	63446478
Arthralgia	54.24	11.79	189	40999	569521	62878313
Chronic kidney disease	54.22	11.79	102	41086	45296	63402538
Toxicity to various agents	53.45	11.79	49	41139	247201	63200633
Neutralising antibodies positive	52.21	11.79	15	41173	250	63447584
Drug specific antibody absent	51.32	11.79	12	41176	83	63447751
Acute myocardial infarction	51.21	11.79	82	41106	32042	63415792
Full blood count decreased	50.81	11.79	73	41115	25951	63421883
Neutropenia	50.41	11.79	236	40952	174769	63273065
Bone marrow failure	49.79	11.79	77	41111	29213	63418621
Serum ferritin increased	49.24	11.79	37	41151	6145	63441689
Skin hyperpigmentation	48.41	11.79	36	41152	5885	63441949
Wound	46.37	11.79	24	41164	163239	63284595
Shunt occlusion	45.89	11.79	17	41171	648	63447186
Cardiac failure congestive	45.77	11.79	148	41040	92285	63355549
Helicobacter infection	45.39	11.79	4	41184	92781	63355053
Joint contracture	44.66	11.79	22	41166	1702	63446132
Therapeutic product effect incomplete	44.38	11.79	13	41175	125043	63322791
Swelling	44.16	11.79	69	41119	275309	63172525
Discomfort	41.37	11.79	29	41159	167345	63280489
Deep vein thrombosis	41.33	11.79	134	41054	83666	63364168
White blood cell count decreased	41.08	11.79	189	40999	138915	63308919
Iron overload	41.06	11.79	17	41171	874	63446960
Cardiac failure	40.81	11.79	139	41049	89003	63358831
Transfusion	39.40	11.79	49	41139	15168	63432666
Irritable bowel syndrome	39.12	11.79	4	41184	82408	63365426
Diabetic foot	39.09	11.79	19	41169	1428	63446406
Fryns syndrome	38.78	11.79	9	41179	60	63447774
Nasopharyngitis	38.61	11.79	66	41122	254191	63193643
Fungal peritonitis	38.27	11.79	14	41174	515	63447319
Blood product transfusion dependent	38.19	11.79	11	41177	185	63447649
Fibromyalgia	37.93	11.79	4	41184	80416	63367418
Oesophageal atresia	37.61	11.79	14	41174	541	63447293
Intentional product use issue	37.52	11.79	18	41170	127874	63319960
Red blood cell count decreased	36.31	11.79	81	41107	40564	63407270
Hyperparathyroidism secondary	35.87	11.79	18	41170	1449	63446385
Haemodialysis	35.51	11.79	36	41152	8911	63438923
Congenital nail disorder	35.11	11.79	9	41179	95	63447739
Blood creatinine increased	35.09	11.79	131	41057	87713	63360121
Blood cholesterol increased	34.81	11.79	9	41179	94023	63353811
Folliculitis	34.48	11.79	3	41185	70314	63377520
Premature delivery	33.65	11.79	66	41122	30215	63417619
Drug abuse	33.21	11.79	4	41184	72514	63375320
Peritoneal dialysis	32.86	11.79	12	41176	439	63447395
Kidney transplant rejection	32.77	11.79	25	41163	4246	63443588
Congenital diaphragmatic hernia	32.73	11.79	10	41178	208	63447626
Blood iron increased	32.16	11.79	17	41171	1525	63446309
Cerebrovascular accident	32.05	11.79	147	41041	107877	63339957
Asthma	31.65	11.79	22	41166	127539	63320295
Hypotension	30.93	11.79	291	40897	272313	63175521
Condition aggravated	30.91	11.79	145	41043	402072	63045762
Pain	30.73	11.79	320	40868	740308	62707526
Metabolic encephalopathy	29.94	11.79	27	41161	5782	63442052
Pulmonary hypoplasia	29.82	11.79	10	41178	283	63447551
Cerebellar stroke	29.79	11.79	10	41178	284	63447550
Athetosis	29.50	11.79	7	41181	52	63447782
Dehydration	28.28	11.79	201	40987	173153	63274681
Hyperkalaemia	27.92	11.79	88	41100	54115	63393719
Akathisia	27.87	11.79	32	41156	9114	63438720
Non-neutralising antibodies positive	27.77	11.79	5	41183	6	63447828
Lower respiratory tract infection	27.65	11.79	27	41161	132280	63315554
Blood urea increased	27.52	11.79	56	41132	26323	63421511
Psoriasis	27.46	11.79	11	41177	86946	63360888
Microtia	26.75	11.79	10	41178	391	63447443
Expired product administered	26.62	11.79	26	41162	6155	63441679
Bone pain	26.59	11.79	87	41101	54554	63393280
Suicide attempt	26.37	11.79	4	41184	60914	63386920
Sleep disorder	26.28	11.79	10	41178	81556	63366278
Porphyria	26.20	11.79	8	41180	166	63447668
Renal impairment	26.03	11.79	120	41068	88235	63359599
Blood parathyroid hormone increased	26.03	11.79	19	41169	3019	63444815
Scar	25.94	11.79	38	41150	13744	63434090
Pseudomonal bacteraemia	25.86	11.79	15	41173	1613	63446221
Septic shock	25.48	11.79	98	41090	66531	63381303
Pneumonia	25.16	11.79	426	40762	456341	62991493
Haemoglobin increased	25.07	11.79	20	41168	3626	63444208
Knee arthroplasty	24.79	11.79	3	41185	54203	63393631
Complications of transplanted kidney	24.66	11.79	17	41171	2469	63445365
Malnutrition	24.31	11.79	39	41149	15259	63432575
Reticulocyte count abnormal	24.27	11.79	6	41182	54	63447780
Toxoplasmosis	24.11	11.79	14	41174	1509	63446325
Endometrial disorder	23.95	11.79	11	41177	728	63447106
Product administration error	23.90	11.79	48	41140	22349	63425485
Peritoneal cloudy effluent	23.31	11.79	7	41181	137	63447697
Ill-defined disorder	23.23	11.79	12	41176	81743	63366091
Peau d'orange	23.03	11.79	7	41181	143	63447691
Tracheo-oesophageal fistula	22.98	11.79	10	41178	582	63447252
Mental status changes	22.94	11.79	67	41121	39532	63408302
Transfusion reaction	22.86	11.79	12	41176	1061	63446773
Intensive care unit acquired weakness	22.84	11.79	11	41177	810	63447024
Splenomegaly	22.81	11.79	32	41156	11125	63436709
Musculoskeletal stiffness	22.81	11.79	54	41134	184564	63263270
Disease progression	22.80	11.79	147	41041	122611	63325223
Blood albumin decreased	22.59	11.79	37	41151	14729	63433105
Overdose	22.34	11.79	25	41163	115053	63332781
Peripheral swelling	22.14	11.79	93	41095	265849	63181985
Graft infection	22.13	11.79	7	41181	164	63447670
Iron deficiency	21.53	11.79	25	41163	7205	63440629
Hyperphosphataemia	21.42	11.79	15	41173	2233	63445601
Marrow hyperplasia	21.40	11.79	10	41178	688	63447146
Injection site erythema	21.09	11.79	14	41174	83160	63364674
Blood phosphorus increased	21.09	11.79	17	41171	3128	63444706
Drug interaction	21.06	11.79	77	41111	229054	63218780
Parvovirus B19 test positive	20.94	11.79	6	41182	99	63447735
Extremity contracture	20.84	11.79	12	41176	1273	63446561
Haemolytic anaemia	20.64	11.79	29	41159	10096	63437738
Atrial fibrillation	20.04	11.79	137	41051	116499	63331335
Coarctation of the aorta	19.96	11.79	9	41179	570	63447264
Failure to thrive	19.96	11.79	24	41164	7174	63440660
Arthritis	19.57	11.79	28	41160	115893	63331941
Blister	19.41	11.79	34	41154	129780	63318054
Blood potassium increased	19.25	11.79	39	41149	18270	63429564
Craniofacial deformity	19.19	11.79	6	41182	135	63447699
Enterococcus test positive	19.14	11.79	11	41177	1162	63446672
Blood erythropoietin abnormal	19.02	11.79	3	41185	0	63447834
Immunosuppressant drug level increased	18.93	11.79	17	41171	3621	63444213
Anhedonia	18.86	11.79	29	41159	10945	63436889
Cerebrovascular disorder	18.81	11.79	15	41173	2717	63445117
Red blood cell sedimentation rate increased	18.78	11.79	3	41185	43979	63403855
Low birth weight baby	18.52	11.79	23	41165	7106	63440728
Skin mass	18.42	11.79	21	41167	5934	63441900
Migraine	18.41	11.79	24	41164	103322	63344512
Bone marrow disorder	18.24	11.79	14	41174	2400	63445434
Ascites	18.18	11.79	63	41125	40665	63407169
Loss of personal independence in daily activities	17.95	11.79	22	41166	97268	63350566
Cleft palate	17.89	11.79	10	41178	1002	63446832
C-reactive protein abnormal	17.87	11.79	4	41184	46092	63401742
Haemolysis	17.85	11.79	22	41166	6746	63441088
Hypocalcaemia	17.74	11.79	53	41135	31660	63416174
Full blood count abnormal	17.74	11.79	53	41135	31664	63416170
Soft tissue infection	17.49	11.79	13	41175	2124	63445710
Acute myeloid leukaemia	17.41	11.79	36	41152	17111	63430723
Heparin-induced thrombocytopenia	17.39	11.79	18	41170	4564	63443270
Leg amputation	17.34	11.79	13	41175	2151	63445683
Product use in unapproved indication	17.24	11.79	59	41129	179021	63268813
Type 2 diabetes mellitus	17.23	11.79	10	41178	63858	63383976
Weight increased	17.19	11.79	99	41089	260693	63187141
Leukopenia	17.18	11.79	97	41091	77193	63370641
Red blood cell count abnormal	17.08	11.79	10	41178	1094	63446740
Maternal exposure during pregnancy	17.07	11.79	79	41109	219983	63227851
Blood erythropoietin decreased	16.95	11.79	3	41185	3	63447831
Pleural effusion	16.92	11.79	111	41077	93099	63354735
Hip arthroplasty	16.81	11.79	5	41183	47641	63400193
Erythema infectiosum	16.69	11.79	5	41183	97	63447737
Peripheral sensorimotor neuropathy	16.63	11.79	11	41177	1492	63446342
Urinary tract infection	16.46	11.79	252	40936	264432	63183402
Skin discolouration	16.44	11.79	58	41130	37770	63410064
Adenocarcinoma metastatic	16.41	11.79	5	41183	103	63447731
Refusal of treatment by patient	16.36	11.79	19	41169	5478	63442356
Conjunctival discolouration	16.32	11.79	5	41183	105	63447729
Impaired healing	16.12	11.79	26	41162	102516	63345318
Anti-erythropoietin antibody	16.08	11.79	3	41185	5	63447829
Emotional distress	15.99	11.79	52	41136	32497	63415337
Transferrin saturation increased	15.80	11.79	4	41184	40	63447794
Folate deficiency	15.80	11.79	13	41175	2462	63445372
Oropharyngeal pain	15.77	11.79	23	41165	94464	63353370
Skin plaque	15.74	11.79	23	41165	8297	63439537
Retinal artery occlusion	15.68	11.79	11	41177	1642	63446192
Endocarditis	15.66	11.79	19	41169	5731	63442103
Micturition disorder	15.51	11.79	13	41175	2525	63445309
Vascular parkinsonism	15.42	11.79	5	41183	127	63447707
Respiratory failure	15.39	11.79	116	41072	101742	63346092
Myelofibrosis	15.05	11.79	10	41178	1367	63446467
Biopsy bone marrow abnormal	14.88	11.79	6	41182	288	63447546
Inappropriate schedule of product administration	14.85	11.79	28	41160	103937	63343897
Peripheral ischaemia	14.75	11.79	17	41171	4861	63442973
Gangrene	14.71	11.79	19	41169	6104	63441730
Cognitive disorder	14.69	11.79	9	41179	55806	63392028
Generalised oedema	14.66	11.79	32	41156	15786	63432048
Vascular calcification	14.66	11.79	8	41180	765	63447069
Acute pulmonary oedema	14.64	11.79	22	41166	8136	63439698
Drug-induced liver injury	14.60	11.79	4	41184	40218	63407616
Haemorrhage	14.51	11.79	78	41110	60944	63386890
Premature rupture of membranes	14.43	11.79	17	41171	4976	63442858
Urticaria	14.40	11.79	57	41131	165745	63282089
Renal atrophy	14.38	11.79	10	41178	1472	63446362
Gastrointestinal haemorrhage	14.33	11.79	96	41092	81080	63366754
Azotaemia	14.23	11.79	16	41172	4455	63443379
Arteriovenous graft site infection	14.20	11.79	3	41185	12	63447822
Arteriovenous graft site haemorrhage	14.20	11.79	3	41185	12	63447822
Abdominal pain	14.10	11.79	268	40920	293188	63154646
Epistaxis	14.06	11.79	88	41100	72637	63375197
Vomiting	14.02	11.79	468	40720	559149	62888685
C-reactive protein increased	13.98	11.79	25	41163	94682	63353152
Therapeutic drug monitoring analysis incorrectly performed	13.97	11.79	6	41182	338	63447496
Renal lymphocele	13.96	11.79	4	41184	66	63447768
Enterococcal infection	13.85	11.79	21	41167	7827	63440007
Normochromic normocytic anaemia	13.75	11.79	16	41172	4620	63443214
Cardiorenal syndrome	13.73	11.79	8	41180	867	63446967
Thrombosis in device	13.67	11.79	13	41175	2977	63444857
Injection site swelling	13.48	11.79	7	41181	47565	63400269
Sickle cell anaemia with crisis	13.45	11.79	18	41170	5985	63441849
Angiodermatitis	13.38	11.79	4	41184	77	63447757
Injection site reaction	13.35	11.79	11	41177	58513	63389321
Intercepted product administration error	13.25	11.79	6	41182	384	63447450
Heart disease congenital	13.16	11.79	9	41179	1290	63446544
Acute kidney injury	13.15	11.79	242	40946	263173	63184661
Haemosiderosis	13.10	11.79	5	41183	207	63447627
Ultrafiltration failure	13.08	11.79	5	41183	208	63447626
Nephrogenic anaemia	13.06	11.79	11	41177	2151	63445683
Nasal congestion	13.03	11.79	14	41174	65646	63382188
Device related infection	12.99	11.79	39	41149	23353	63424481
Insomnia	12.99	11.79	84	41104	215168	63232666
Therapeutic response delayed	12.95	11.79	7	41181	657	63447177
Disease complication	12.90	11.79	13	41175	3196	63444638
Uterine dilation and evacuation	12.80	11.79	3	41185	21	63447813
Vascular graft thrombosis	12.80	11.79	3	41185	21	63447813
Dermatitis bullous	12.58	11.79	21	41167	8487	63439347
Dialysis device insertion	12.56	11.79	3	41185	23	63447811
Dysmorphism	12.49	11.79	11	41177	2285	63445549
COVID-19	12.49	11.79	35	41153	113068	63334766
Memory impairment	12.47	11.79	31	41157	104227	63343607
Myelopathy	12.38	11.79	12	41176	2814	63445020
Leukocytosis	12.35	11.79	41	41147	25894	63421940
Unresponsive to stimuli	12.32	11.79	49	41139	33767	63414067
Decreased appetite	12.31	11.79	230	40958	250822	63197012
Injection site pruritus	12.26	11.79	7	41181	45109	63402725
Delirium	12.16	11.79	9	41179	50532	63397302
Delayed graft function	12.10	11.79	8	41180	1085	63446749
Parathyroidectomy	12.06	11.79	5	41183	258	63447576
Congestive hepatopathy	11.97	11.79	12	41176	2930	63444904

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplasia pure red cell	749.45	12.12	272	37013	5860	34913786
Haemoglobin decreased	475.26	12.12	613	36672	120159	34799487
Therapeutic response decreased	451.99	12.12	318	36967	28995	34890651
Nephrogenic systemic fibrosis	353.07	12.12	140	37145	3865	34915781
Anti-erythropoietin antibody positive	279.75	12.12	81	37204	814	34918832
Product storage error	225.56	12.12	128	37157	7994	34911652
Anaemia	220.24	12.12	645	36640	232690	34686956
Death	181.44	12.12	870	36415	397179	34522467
Skin induration	161.43	12.12	67	37218	2084	34917562
Haemoglobin abnormal	152.32	12.12	77	37208	3803	34915843
Peritonitis bacterial	124.70	12.12	79	37206	6031	34913615
Skin hypertrophy	117.53	12.12	57	37228	2572	34917074
Myelodysplastic syndrome	114.52	12.12	121	37164	19087	34900559
Skin tightness	104.20	12.12	50	37235	2203	34917443
Shunt stenosis	100.39	12.12	36	37249	746	34918900
Device interaction	94.80	12.12	32	37253	550	34919096
Toxicity to various agents	92.91	12.12	49	37236	200313	34719333
Reticulocyte count decreased	92.88	12.12	33	37252	665	34918981
Plasma cell myeloma	83.51	12.12	156	37129	41881	34877765
Anti-erythropoietin antibody negative	83.01	12.12	23	37262	194	34919452
Renal transplant	82.38	12.12	40	37245	1809	34917837
Joint contracture	80.15	12.12	40	37245	1921	34917725
Skin fibrosis	79.72	12.12	33	37252	1019	34918627
Peritoneal dialysis complication	76.23	12.12	37	37248	1672	34917974
Drug interaction	70.93	12.12	82	37203	225864	34693782
Chronic kidney disease	66.27	12.12	140	37145	41070	34878576
Peritonitis	60.83	12.12	81	37204	16284	34903362
Pancytopenia	60.70	12.12	231	37054	94926	34824720
Refractory cytopenia with unilineage dysplasia	58.37	12.12	22	37263	527	34919119
Shunt occlusion	58.28	12.12	25	37260	845	34918801
Joint range of motion decreased	56.39	12.12	53	37232	7259	34912387
Fibrosis	54.78	12.12	34	37251	2502	34917144
Dialysis	52.04	12.12	62	37223	11146	34908500
Platelet count decreased	51.38	12.12	258	37027	119459	34800187
Serum ferritin increased	50.20	12.12	46	37239	6100	34913546
Scar	47.60	12.12	44	37241	5900	34913746
Extremity contracture	47.23	12.12	21	37264	775	34918871
Diabetic foot	47.02	12.12	32	37253	2756	34916890
Neutralising antibodies positive	44.32	12.12	12	37273	92	34919554
Nephrogenic anaemia	43.65	12.12	28	37257	2183	34917463
Asthenia	42.72	12.12	424	36861	244827	34674819
Iron overload	39.69	12.12	22	37263	1311	34918335
Blood iron abnormal	39.49	12.12	10	37275	57	34919589
Intentional product use issue	39.23	12.12	8	37277	59808	34859838
Blood iron increased	38.97	12.12	19	37266	867	34918779
Cardio-respiratory arrest	37.56	12.12	137	37148	55136	34864510
Marrow hyperplasia	36.85	12.12	20	37265	1143	34918503
Oedema peripheral	36.72	12.12	236	37049	119576	34800070
Deformity	36.32	12.12	22	37263	1550	34918096
Non-neutralising antibodies positive	36.13	12.12	10	37275	84	34919562
Hospitalisation	35.31	12.12	137	37148	56765	34862881
Haemoglobin increased	34.86	12.12	29	37256	3380	34916266
Transfusion	34.24	12.12	44	37241	8541	34911105
Blood parathyroid hormone increased	31.95	12.12	20	37265	1494	34918152
Peau d'orange	31.38	12.12	10	37275	142	34919504
Thrombocytopenia	30.56	12.12	277	37008	155970	34763676
Cellulitis enterococcal	29.94	12.12	9	37276	104	34919542
Blood erythropoietin increased	29.58	12.12	6	37279	9	34919637
Drug ineffective	28.96	12.12	330	36955	456421	34463225
Anhedonia	28.89	12.12	38	37247	7547	34912099
Haemodialysis	28.72	12.12	45	37240	10481	34909165
Blood product transfusion dependent	28.38	12.12	12	37273	391	34919255
Febrile bone marrow aplasia	28.03	12.12	39	37246	8170	34911476
Hyperparathyroidism	27.94	12.12	17	37268	1207	34918439
Bone marrow failure	27.51	12.12	81	37204	29172	34890474
Treatment failure	27.20	12.12	8	37277	46689	34872957
Iron deficiency	27.03	12.12	31	37254	5350	34914296
Hyperparathyroidism secondary	26.45	12.12	18	37267	1550	34918096
Splenomegaly	26.21	12.12	53	37232	15064	34904582
Hypervolaemia	26.10	12.12	62	37223	19647	34899999
Weight increased	25.78	12.12	37	37248	92996	34826650
Blood urea increased	25.67	12.12	81	37204	30283	34889363
Rhabdomyolysis	25.66	12.12	21	37264	68142	34851504
Acute myocardial infarction	25.32	12.12	119	37166	53600	34866046
Rheumatoid arthritis	25.31	12.12	5	37280	38233	34881413
Product use in unapproved indication	25.09	12.12	55	37230	117444	34802202
Red blood cell count decreased	24.96	12.12	78	37207	29012	34890634
Calciphylaxis	24.50	12.12	15	37270	1077	34918569
Intentional product misuse	24.48	12.12	9	37276	45602	34874044
Overdose	24.47	12.12	37	37248	91022	34828624
Parvovirus B19 test positive	24.17	12.12	8	37277	129	34919517
Suicidal ideation	23.38	12.12	7	37278	40381	34879265
Therapy non-responder	23.27	12.12	93	37192	39053	34880593
Haematocrit decreased	22.85	12.12	81	37204	32135	34887511
Skin hyperpigmentation	22.05	12.12	22	37263	3242	34916404
Transferrin saturation increased	21.99	12.12	7	37278	99	34919547
Kidney transplant rejection	21.78	12.12	33	37252	7464	34912182
Incision site pain	21.68	12.12	17	37268	1821	34917825
Reticulocyte count increased	21.42	12.12	11	37274	561	34919085
Cardiac failure congestive	21.32	12.12	157	37128	83113	34836533
Haematocrit abnormal	21.20	12.12	12	37273	745	34918901
Interstitial lung disease	21.18	12.12	23	37262	65259	34854387
Drug-induced liver injury	20.78	12.12	3	37282	28829	34890817
Azotaemia	20.67	12.12	26	37259	4941	34914705
Iron binding capacity total decreased	20.59	12.12	7	37278	123	34919523
Erythropoiesis abnormal	20.47	12.12	8	37277	212	34919434
Pleural effusion	20.45	12.12	153	37132	81393	34838253
Noninfectious peritonitis	20.43	12.12	7	37278	126	34919520
Aggression	20.39	12.12	8	37277	38956	34880690
Therapeutic response delayed	20.29	12.12	11	37274	627	34919019
Transferrin saturation decreased	20.25	12.12	10	37275	469	34919177
Product use issue	19.72	12.12	23	37262	63193	34856453
Haemolytic anaemia	19.69	12.12	38	37247	10441	34909205
Arteriovenous fistula operation	19.57	12.12	7	37278	144	34919502
Renal failure	19.50	12.12	219	37066	130338	34789308
Morganella infection	19.44	12.12	10	37275	512	34919134
Ultrafiltration failure	19.04	12.12	7	37278	156	34919490
Erythema infectiosum	18.68	12.12	7	37278	165	34919481
Emotional distress	18.54	12.12	46	37239	14980	34904666
Reticulocyte count abnormal	18.38	12.12	4	37281	10	34919636
Parathyroidectomy	18.35	12.12	6	37279	93	34919553
Shunt infection	18.23	12.12	6	37279	95	34919551
Renal disorder	18.01	12.12	64	37221	25416	34894230
Infusion related reaction	17.99	12.12	18	37267	53039	34866607
Cerebrovascular accident	17.92	12.12	153	37132	84658	34834988
Inadequate osteointegration	17.85	12.12	4	37281	12	34919634
Bloody peritoneal effluent	17.57	12.12	6	37279	107	34919539
Iron binding capacity total abnormal	17.53	12.12	3	37282	0	34919646
Transferrin abnormal	17.53	12.12	3	37282	0	34919646
Complications of transplanted kidney	17.41	12.12	23	37262	4586	34915060
Therapeutic product effect incomplete	17.31	12.12	17	37268	50524	34869122
Deep vein thrombosis	17.26	12.12	124	37161	65124	34854522
Inappropriate schedule of product administration	17.03	12.12	25	37260	62271	34857375
Dependence on oxygen therapy	16.97	12.12	7	37278	214	34919432
Reticulocytopenia	16.93	12.12	6	37279	120	34919526
Drug reaction with eosinophilia and systemic symptoms	16.91	12.12	7	37278	33005	34886641
Agitation	16.73	12.12	22	37263	57377	34862269
Bronchial haemorrhage	16.58	12.12	10	37275	699	34918947
Drug dependence	16.38	12.12	3	37282	24214	34895432
Expired product administered	16.37	12.12	19	37266	3322	34916324
Hepatic function abnormal	16.28	12.12	14	37271	44349	34875297
Psoriasis	15.83	12.12	11	37274	38801	34880845
Dental restoration failure	15.62	12.12	4	37281	24	34919622
Nasopharyngitis	15.56	12.12	32	37253	69936	34849710
Peritoneal dialysis	15.41	12.12	9	37276	593	34919053
Bone marrow reticulin fibrosis	15.11	12.12	6	37279	166	34919480
Headache	15.10	12.12	139	37146	200496	34719150
Haemochromatosis	14.90	12.12	11	37274	1077	34918569
Malnutrition	14.73	12.12	38	37247	12671	34906975
Condition aggravated	14.53	12.12	133	37152	192063	34727583
Biopsy bone marrow abnormal	14.51	12.12	7	37278	312	34919334
Shunt malfunction	14.41	12.12	6	37279	188	34919458
Chronic hepatitis	14.28	12.12	9	37276	680	34918966
Bone marrow disorder	14.20	12.12	13	37272	1722	34917924
Right ventricular dilatation	14.14	12.12	9	37276	692	34918954
Ureteric stenosis	14.14	12.12	11	37274	1165	34918481
Disturbance in attention	14.13	12.12	5	37280	25940	34893706
Normochromic normocytic anaemia	14.09	12.12	20	37265	4267	34915379
Arteriovenous fistula thrombosis	14.03	12.12	7	37278	336	34919310
Asthma	13.87	12.12	15	37270	42641	34877005
Porphyria	13.83	12.12	4	37281	40	34919606
Sepsis	13.83	12.12	252	37033	166309	34753337
Hallucination	13.75	12.12	21	37264	51477	34868169
Red blood cells urine positive	13.73	12.12	13	37272	1796	34917850
Hyperviscosity syndrome	13.68	12.12	6	37279	214	34919432
Mobility decreased	13.65	12.12	66	37219	30062	34889584
Hyponatraemia	13.63	12.12	44	37241	82647	34836999
Inferior vena cava dilatation	13.48	12.12	9	37276	751	34918895
Drug intolerance	13.45	12.12	27	37258	59543	34860103
Cholestasis	13.35	12.12	6	37279	26942	34892704
Stress	13.19	12.12	8	37277	30339	34889307
Ecchymosis	13.19	12.12	25	37260	6778	34912868
Urethral meatus stenosis	13.17	12.12	4	37281	48	34919598
Serum ferritin abnormal	13.14	12.12	6	37279	236	34919410
Hypocalcaemia	13.09	12.12	56	37229	24233	34895413
Myelofibrosis	13.04	12.12	12	37273	1599	34918047
Injury	12.98	12.12	50	37235	20637	34899009
Pruritus	12.92	12.12	218	37067	141763	34777883
Refractory anaemia with an excess of blasts	12.74	12.12	7	37278	410	34919236
Delirium	12.67	12.12	17	37268	43974	34875672
Alanine aminotransferase increased	12.63	12.12	44	37241	80771	34838875
Arteriovenous fistula occlusion	12.57	12.12	5	37280	139	34919507
Proteus infection	12.55	12.12	10	37275	1096	34918550
Insomnia	12.27	12.12	63	37222	103844	34815802

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplasia pure red cell	1003.92	10.82	330	60065	7480	79676513
Haemoglobin decreased	760.21	10.82	887	59508	221232	79462761
Nephrogenic systemic fibrosis	617.42	10.82	216	60179	5944	79678049
Death	486.05	10.82	1217	59178	565297	79118696
Product storage error	436.02	10.82	223	60172	16003	79667990
Anaemia	392.58	10.82	967	59428	444048	79239945
Anti-erythropoietin antibody positive	370.55	10.82	90	60305	627	79683366
Haemoglobin abnormal	306.48	10.82	135	60260	6919	79677074
Peritonitis bacterial	293.88	10.82	144	60251	9423	79674570
Skin induration	254.43	10.82	104	60291	4421	79679572
Shunt stenosis	246.00	10.82	75	60320	1316	79682677
Anti-erythropoietin antibody negative	241.77	10.82	55	60340	276	79683717
Skin hypertrophy	203.44	10.82	91	60304	4837	79679156
Skin tightness	181.29	10.82	87	60308	5435	79678558
Therapeutic response decreased	179.73	10.82	237	60158	66616	79617377
Completed suicide	171.03	10.82	3	60392	245764	79438229
Plasma cell myeloma	168.84	10.82	205	60190	53054	79630939
Peritoneal dialysis complication	156.31	10.82	61	60334	2293	79681700
Myelodysplastic syndrome	139.87	10.82	142	60253	30159	79653834
Skin fibrosis	135.85	10.82	49	60346	1475	79682518
Toxicity to various agents	126.26	10.82	82	60313	421458	79262535
Peritonitis	123.28	10.82	128	60267	27908	79656085
Cardio-respiratory arrest	118.45	10.82	257	60138	108253	79575740
Thrombocytopenia	115.13	10.82	451	59944	264808	79419185
Chronic kidney disease	112.19	10.82	189	60206	65965	79618028
Shunt occlusion	110.67	10.82	42	60353	1462	79682531
Platelet count decreased	107.41	10.82	358	60037	194306	79489687
Pancytopenia	107.18	10.82	322	60073	165423	79518570
Drug abuse	105.62	10.82	4	60391	162687	79521306
Haematocrit decreased	102.42	10.82	174	60221	61138	79622855
Joint contracture	102.24	10.82	46	60349	2478	79681515
Drug intolerance	100.81	10.82	37	60358	264082	79419911
Fibrosis	98.18	10.82	57	60338	5252	79678741
Reticulocyte count decreased	95.22	10.82	33	60362	881	79683112
Refractory cytopenia with unilineage dysplasia	94.84	10.82	33	60362	892	79683101
Rheumatoid arthritis	94.68	10.82	21	60374	208449	79475544
Asthenia	94.61	10.82	687	59708	511002	79172991
Sepsis	93.51	10.82	428	59967	269000	79414993
Drug ineffective	93.40	10.82	462	59933	1080451	78603542
Diabetic foot	89.17	10.82	47	60348	3585	79680408
Synovitis	87.71	10.82	7	60388	150727	79533266
Renal transplant	86.26	10.82	41	60354	2506	79681487
Hospitalisation	84.94	10.82	207	60188	94029	79589964
Dialysis	84.25	10.82	86	60309	18376	79665617
Hyperparathyroidism	82.80	10.82	43	60352	3181	79680812
Renal failure	80.98	10.82	334	60061	200634	79483359
Acute myocardial infarction	80.13	10.82	179	60216	76857	79607136
Joint swelling	78.68	10.82	62	60333	288584	79395409
Device interaction	77.83	10.82	27	60368	723	79683270
Contraindicated product administered	77.59	10.82	13	60382	157525	79526468
Neutralising antibodies positive	74.92	10.82	21	60374	270	79683723
Oedema peripheral	71.25	10.82	378	60017	251910	79432083
Calciphylaxis	71.11	10.82	41	60354	3729	79680264
Arteriovenous fistula site complication	70.55	10.82	27	60368	962	79683031
Iron overload	69.29	10.82	32	60363	1832	79682161
Hypervolaemia	68.46	10.82	119	60276	42571	79641422
Haematocrit abnormal	68.44	10.82	30	60365	1518	79682475
Treatment failure	68.28	10.82	22	60373	170464	79513529
Headache	68.12	10.82	260	60135	653512	79030481
Arthropathy	67.24	10.82	25	60370	177086	79506907
Hepatic enzyme increased	65.68	10.82	28	60367	182582	79501411
Infusion related reaction	64.59	10.82	48	60347	230189	79453804
Intentional product use issue	63.87	10.82	18	60377	152094	79531899
Hand deformity	62.83	10.82	4	60391	103915	79580078
Blood urea increased	59.54	10.82	121	60274	48669	79635324
Product use issue	58.52	10.82	44	60351	209778	79474215
Skin hyperpigmentation	56.99	10.82	46	60349	7257	79676736
Transfusion	56.33	10.82	75	60320	21255	79662738
Cerebrovascular accident	54.77	10.82	248	60147	155044	79528949
Sinusitis	54.51	10.82	41	60354	195460	79488533
Haemodialysis	54.43	10.82	68	60327	18100	79665893
Scar	53.94	10.82	62	60333	15134	79668859
Serum ferritin increased	52.61	10.82	50	60345	9797	79674196
Glossodynia	52.06	10.82	8	60387	103329	79580664
Arthralgia	51.71	10.82	240	60155	571563	79112430
Blood product transfusion dependent	50.53	10.82	17	60378	414	79683579
Alopecia	48.91	10.82	62	60333	231293	79452700
Red blood cell count decreased	48.30	10.82	123	60272	57390	79626603
Marrow hyperplasia	48.21	10.82	24	60371	1624	79682369
Condition aggravated	47.90	10.82	206	60189	500918	79183075
Nasopharyngitis	47.73	10.82	74	60321	253807	79430186
Therapeutic product effect incomplete	47.40	10.82	24	60371	141621	79542372
Cardiac failure	47.14	10.82	237	60158	154605	79529388
Drug hypersensitivity	46.47	10.82	98	60297	298818	79385175
Cardiac failure congestive	46.23	10.82	222	60173	142180	79541813
Hyperparathyroidism secondary	45.10	10.82	27	60368	2633	79681360
Asthma	43.57	10.82	24	60371	135071	79548922
Drug specific antibody absent	43.18	10.82	13	60382	218	79683775
Systemic lupus erythematosus	42.88	10.82	19	60376	121130	79562863
Bone marrow failure	42.60	10.82	109	60286	50998	79632995
Deep vein thrombosis	42.54	10.82	193	60202	120726	79563267
Peau d'orange	42.00	10.82	14	60381	331	79683662
Drug interaction	41.94	10.82	167	60228	415016	79268977
Splenomegaly	41.60	10.82	64	60331	20690	79663303
Neutropenia	41.37	10.82	365	60030	287345	79396648
Fungal peritonitis	41.25	10.82	19	60376	1081	79682912
Septic shock	40.26	10.82	192	60203	122609	79561384
Cellulitis enterococcal	39.75	10.82	9	60386	44	79683949
Blood creatinine increased	38.83	10.82	225	60170	154832	79529161
Extremity contracture	38.55	10.82	21	60374	1711	79682282
Helicobacter infection	38.49	10.82	4	60391	69700	79614293
Kidney transplant rejection	36.70	10.82	42	60353	10204	79673789
Duodenal ulcer perforation	36.05	10.82	4	60391	66207	79617786
Weight increased	35.95	10.82	100	60295	277286	79406707
Pericarditis	35.87	10.82	17	60378	104219	79579774
Overdose	35.28	10.82	53	60342	184153	79499840
Abdominal discomfort	35.07	10.82	87	60308	250640	79433353
Fibromyalgia	34.75	10.82	4	60391	64336	79619657
Haemoglobin increased	34.42	10.82	32	60363	6100	79677893
Peritoneal cloudy effluent	34.39	10.82	12	60383	327	79683666
Nephrogenic anaemia	33.50	10.82	26	60369	3876	79680117
Ultrafiltration failure	33.37	10.82	11	60384	251	79683742
Hypocalcaemia	33.17	10.82	98	60297	49826	79634167
Joint range of motion decreased	33.10	10.82	76	60319	33206	79650787
Pneumonia	32.85	10.82	691	59704	659555	79024438
Anhedonia	32.79	10.82	48	60347	14850	79669143
Non-neutralising antibodies positive	32.30	10.82	8	60387	61	79683932
Blood parathyroid hormone increased	31.87	10.82	24	60371	3421	79680572
Psoriasis	31.78	10.82	14	60381	89573	79594420
Porphyria	31.67	10.82	10	60385	198	79683795
Reticulocyte count abnormal	31.53	10.82	8	60387	68	79683925
Blood iron increased	31.47	10.82	18	60377	1612	79682381
Irritable bowel syndrome	30.94	10.82	5	60390	62236	79621757
Intentional product misuse	30.54	10.82	17	60378	95148	79588845
Iron deficiency	30.52	10.82	39	60356	10615	79673378
Haemolytic anaemia	30.31	10.82	51	60344	17769	79666224
White blood cell count decreased	29.74	10.82	244	60151	188044	79495949
Therapeutic product effect decreased	29.61	10.82	49	60346	163814	79520179
Noninfectious peritonitis	29.59	10.82	10	60385	247	79683746
Drug-induced liver injury	29.32	10.82	7	60388	66110	79617883
Bloody peritoneal effluent	28.85	10.82	9	60386	171	79683822
Full blood count decreased	28.64	10.82	63	60332	26756	79657237
Pleural effusion	28.43	10.82	198	60197	145064	79538929
Blood albumin decreased	28.25	10.82	59	60336	24184	79659809
Blood potassium increased	28.18	10.82	66	60329	29209	79654784
Complications of transplanted kidney	27.86	10.82	29	60366	6337	79677656
Product use in unapproved indication	27.67	10.82	97	60298	250262	79433731
Expired product administered	27.12	10.82	30	60365	7021	79676972
Incision site pain	26.81	10.82	20	60375	2810	79681183
Peritoneal dialysis	26.63	10.82	13	60382	843	79683150
Malnutrition	26.50	10.82	55	60340	22447	79661546
Parvovirus B19 test positive	26.47	10.82	8	60387	136	79683857
Athetosis	26.42	10.82	8	60387	137	79683856
Hypotension	26.32	10.82	474	59921	439843	79244150
Arteriovenous fistula operation	26.06	10.82	10	60385	359	79683634
Pain	25.67	10.82	377	60018	703425	78980568
Ill-defined disorder	25.49	10.82	9	60386	65866	79618127
Metabolic encephalopathy	25.45	10.82	33	60362	9114	79674879
Blood cholesterol increased	25.39	10.82	16	60379	83704	79600289
Shunt malfunction	25.23	10.82	9	60386	262	79683731
Sleep disorder	25.14	10.82	17	60378	85660	79598333
Skin discolouration	24.87	10.82	78	60317	40956	79643037
Azotaemia	24.83	10.82	31	60364	8245	79675748
Iron binding capacity total abnormal	24.75	10.82	4	60391	0	79683993
Blood erythropoietin abnormal	24.75	10.82	4	60391	0	79683993
Generalised oedema	24.53	10.82	55	60340	23654	79660339
Hyperphosphataemia	24.31	10.82	27	60368	6349	79677644
Folliculitis	24.29	10.82	6	60389	55374	79628619
Endometrial disorder	24.21	10.82	11	60384	606	79683387
Peripheral swelling	23.82	10.82	114	60281	269503	79414490
Injection site erythema	23.64	10.82	15	60380	78182	79605811
Haemolysis	23.59	10.82	38	60357	12774	79671219
Shunt infection	23.43	10.82	8	60387	204	79683789
Peripheral arterial occlusive disease	23.30	10.82	30	60365	8228	79675765
Morganella infection	23.26	10.82	13	60382	1114	79682879
Liver injury	23.20	10.82	7	60388	56607	79627386
Therapy non-responder	23.13	10.82	134	60261	92171	79591822
Febrile bone marrow aplasia	23.13	10.82	38	60357	12982	79671011
Cytopenia	23.04	10.82	49	60346	20334	79663659
Arthritis	23.02	10.82	32	60363	114848	79569145
Premature delivery	22.69	10.82	53	60342	23414	79660579
Swelling	22.60	10.82	86	60309	216625	79467368
Knee arthroplasty	22.59	10.82	3	60392	43245	79640748
Disease complication	22.53	10.82	23	60372	4914	79679079
Transferrin saturation increased	22.49	10.82	7	60388	132	79683861
Cerebellar stroke	22.05	10.82	10	60385	549	79683444
Wound	21.68	10.82	34	60361	116145	79567848
Insomnia	21.45	10.82	104	60291	245066	79438927
Serum ferritin abnormal	21.34	10.82	9	60386	414	79683579
Loss of personal independence in daily activities	21.14	10.82	28	60367	102552	79581441
End stage renal disease	20.82	10.82	35	60360	12185	79671808
Emotional distress	20.67	10.82	72	60323	39897	79644096
Discomfort	20.51	10.82	40	60355	125577	79558416
Erythropoiesis abnormal	20.36	10.82	9	60386	465	79683528
Sedation	20.23	10.82	7	60388	51888	79632105
Skin exfoliation	20.16	10.82	89	60306	55011	79628982
Hyperkalaemia	20.12	10.82	152	60243	114246	79569747
Red blood cell sedimentation rate increased	20.10	10.82	5	60390	45937	79638056
Renal impairment	20.04	10.82	195	60200	157588	79526405
Migraine	20.02	10.82	22	60373	87471	79596522
C-reactive protein abnormal	19.78	10.82	6	60389	48361	79635632
Inappropriate schedule of product administration	19.76	10.82	45	60350	133583	79550410
Serotonin syndrome	19.51	10.82	5	60390	45022	79638971
Dehydration	19.23	10.82	279	60116	247908	79436085
Arteriovenous graft site haemorrhage	19.21	10.82	4	60391	12	79683981
Inadequate osteointegration	19.21	10.82	4	60391	12	79683981
Urticaria	18.98	10.82	74	60321	185127	79498866
Anaemia of chronic disease	18.97	10.82	16	60379	2682	79681311
Blood erythropoietin decreased	18.97	10.82	4	60391	13	79683980
Delirium	18.58	10.82	22	60373	84605	79599388
Haemochromatosis	18.58	10.82	12	60383	1338	79682655
Oropharyngeal pain	18.57	10.82	34	60361	109319	79574674
Erythroid series abnormal	18.56	10.82	3	60392	0	79683993
Transferrin abnormal	18.56	10.82	3	60392	0	79683993
Peritoneal fluid analysis abnormal	18.55	10.82	5	60390	55	79683938
Iron binding capacity total decreased	18.51	10.82	8	60387	391	79683602
Gangrene	18.47	10.82	28	60367	8936	79675057
Deformity	18.38	10.82	29	60366	9576	79674417
Anti-erythropoietin antibody	18.13	10.82	4	60391	17	79683976
Device related infection	17.93	10.82	62	60333	34232	79649761
Bone marrow disorder	17.91	10.82	17	60378	3326	79680667
Renal disorder	17.73	10.82	71	60324	42034	79641959
Transfusion reaction	17.64	10.82	13	60382	1793	79682200
Bursitis	17.54	10.82	3	60392	35841	79648152
Hepatitis C	17.52	10.82	32	60363	11893	79672100
Gastrointestinal haemorrhage	17.52	10.82	180	60215	147539	79536454
Refractory anaemia with an excess of blasts	17.48	10.82	10	60385	896	79683097
Interstitial lung disease	17.40	10.82	37	60358	112563	79571430
Hip fracture	17.31	10.82	57	60338	30704	79653289
Cholestasis	17.17	10.82	9	60386	52100	79631893
Lower respiratory tract infection	17.16	10.82	46	60349	129174	79554819
Pseudomonal bacteraemia	17.14	10.82	16	60379	3066	79680927
Oxygen saturation decreased	17.09	10.82	46	60349	129001	79554992
Osteonecrosis	16.94	10.82	57	60338	31038	79652955
Graft infection	16.89	10.82	9	60386	702	79683291
Tooth extraction	16.78	10.82	30	60365	10965	79673028
Hypertensive encephalopathy	16.73	10.82	10	60385	972	79683021
Sudden death	16.71	10.82	46	60349	22465	79661528
Nasal congestion	16.70	10.82	20	60375	76532	79607461
Cognitive disorder	16.65	10.82	17	60378	69909	79614084
Biopsy bone marrow abnormal	16.59	10.82	8	60387	505	79683488
Failure to thrive	16.42	10.82	31	60364	11813	79672180
Bone marrow reticulin fibrosis	16.18	10.82	7	60388	343	79683650
Unresponsive to stimuli	15.99	10.82	84	60311	55704	79628289
Injection site reaction	15.90	10.82	11	60384	54774	79629219
Acute pulmonary oedema	15.85	10.82	34	60361	14196	79669797
Arteriovenous fistula thrombosis	15.78	10.82	8	60387	563	79683430
Erythema infectiosum	15.75	10.82	6	60389	211	79683782
Stomatitis	15.45	10.82	58	60337	146699	79537294
Hip arthroplasty	15.43	10.82	4	60391	35752	79648241
Memory impairment	15.43	10.82	39	60356	111695	79572298
Red blood cell count abnormal	15.43	10.82	11	60384	1442	79682551
Blood pressure fluctuation	15.24	10.82	17	60378	67128	79616865
Inferior vena cava dilatation	15.18	10.82	9	60386	862	79683131
Stress	15.14	10.82	23	60372	79589	79604404
Urethral meatus stenosis	15.10	10.82	4	60391	41	79683952
Rhabdomyolysis	15.03	10.82	35	60360	103096	79580897
Disturbance in attention	15.01	10.82	10	60385	50791	79633202
Toxoplasmosis	14.99	10.82	14	60381	2683	79681310
Muscle contracture	14.79	10.82	13	60382	2304	79681689
Blister	14.78	10.82	44	60351	119432	79564561
Vascular parkinsonism	14.77	10.82	5	60390	124	79683869
Skin plaque	14.74	10.82	28	60367	10717	79673276
Protein urine present	14.68	10.82	27	60368	10085	79673908
Dizziness	14.63	10.82	296	60099	526145	79157848
Conjunctival discolouration	14.63	10.82	5	60390	128	79683865
Angioedema	14.43	10.82	22	60373	76013	79607980
Bone debridement	14.42	10.82	7	60388	448	79683545
Wheezing	14.41	10.82	43	60352	116621	79567372
Ecchymosis	14.33	10.82	34	60361	15172	79668821
Folate deficiency	14.16	10.82	15	60380	3345	79680648
Mental status changes	14.13	10.82	93	60302	66866	79617127
Bronchial haemorrhage	14.03	10.82	10	60385	1310	79682683
Hypertensive crisis	14.01	10.82	41	60354	20729	79663264
Bone pain	14.01	10.82	81	60314	55661	79628332
Akathisia	13.99	10.82	31	60364	13228	79670765
Staphylococcal sepsis	13.96	10.82	33	60362	14693	79669300
Soft tissue infection	13.95	10.82	16	60379	3896	79680097
Myelofibrosis	13.94	10.82	13	60382	2487	79681506
Leukopenia	13.82	10.82	142	60253	116371	79567622
Adverse drug reaction	13.80	10.82	18	60377	66374	79617619
Depressed mood	13.72	10.82	10	60385	48470	79635523
Delayed graft function	13.63	10.82	15	60380	3492	79680501
Skin mass	13.61	10.82	23	60372	8040	79675953
Unevaluable event	13.47	10.82	80	60315	55505	79628488
Premature rupture of membranes	13.44	10.82	16	60379	4053	79679940
Chronic kidney disease-mineral and bone disorder	13.28	10.82	7	60388	534	79683459
Vascular calcification	13.25	10.82	9	60386	1091	79682902
Penile squamous cell carcinoma	13.24	10.82	4	60391	68	79683925
Musculoskeletal stiffness	13.21	10.82	78	60317	174930	79509063
Arteriovenous fistula occlusion	13.15	10.82	7	60388	545	79683448
Extremity necrosis	13.12	10.82	14	60381	3147	79680846
Respiratory failure	13.08	10.82	201	60194	180710	79503283
Hepatic function abnormal	13.07	10.82	22	60373	73085	79610908
Asterixis	13.06	10.82	13	60382	2694	79681299
Critical illness	13.03	10.82	6	60389	341	79683652
Basal cell carcinoma	13.00	10.82	6	60389	37369	79646624
Normochromic normocytic anaemia	12.99	10.82	22	60373	7705	79676288
Somnolence	12.98	10.82	117	60278	238864	79445129
Injection site swelling	12.98	10.82	10	60385	47122	79636871
Cerebrovascular disorder	12.95	10.82	15	60380	3690	79680303
Injection site pruritus	12.93	10.82	8	60387	42275	79641718
Transferrin saturation decreased	12.92	10.82	9	60386	1137	79682856
Electrocardiogram QT prolonged	12.91	10.82	31	60364	90355	79593638
Angiodermatitis	12.87	10.82	4	60391	75	79683918
Adenocarcinoma metastatic	12.86	10.82	5	60390	186	79683807
Accidental overdose	12.80	10.82	7	60388	39574	79644419
Obstructive airways disorder	12.69	10.82	4	60391	31455	79652538
Thrombosis in device	12.66	10.82	18	60377	5424	79678569
Intensive care unit acquired weakness	12.65	10.82	11	60384	1922	79682071
Diabetic ketoacidosis	12.63	10.82	5	60390	34117	79649876
COVID-19	12.59	10.82	69	60326	157605	79526388
Hyponatraemia	12.53	10.82	81	60314	177767	79506226
Alanine aminotransferase increased	12.52	10.82	72	60323	162498	79521495
Red blood cells urine positive	12.42	10.82	17	60378	4946	79679047
Dialysis hypotension	12.36	10.82	4	60391	86	79683907
Uterine dilation and evacuation	12.34	10.82	3	60392	21	79683972
Blood erythropoietin increased	12.34	10.82	3	60392	21	79683972
C-reactive protein increased	12.31	10.82	53	60342	128974	79555019
Streptococcal sepsis	12.29	10.82	13	60382	2894	79681099
Haemorrhage	12.25	10.82	114	60281	91004	79592989
Injection site bruising	12.21	10.82	8	60387	40994	79642999
Throat irritation	12.18	10.82	8	60387	40938	79643055
Parathyroidectomy	12.17	10.82	5	60390	215	79683778
Sciatica	12.09	10.82	5	60390	33217	79650776
Drug dependence	12.08	10.82	8	60387	40761	79643232
General physical health deterioration	12.02	10.82	283	60112	274955	79409038
Dry mouth	11.94	10.82	31	60364	87988	79596005
White blood cell count increased	11.92	10.82	97	60298	74536	79609457
Enterococcus test positive	11.85	10.82	11	60384	2093	79681900
Neoplasm progression	11.82	10.82	13	60382	51669	79632324
Refusal of treatment by patient	11.81	10.82	23	60372	8968	79675025
Neuropathy peripheral	11.80	10.82	161	60234	141144	79542849
Heparin-induced thrombocytopenia	11.79	10.82	24	60371	9658	79674335
Reticulocytopenia	11.66	10.82	5	60390	240	79683753
Full blood count abnormal	11.64	10.82	61	60334	40413	79643580
Cardiac infection	11.60	10.82	6	60389	440	79683553
Supraventricular tachycardia	11.60	10.82	39	60356	21231	79662762
Laboratory test abnormal	11.57	10.82	47	60348	28001	79655992
Transplant	11.56	10.82	8	60387	1000	79682993
Blood iron abnormal	11.50	10.82	9	60386	1358	79682635
Body temperature decreased	11.43	10.82	5	60390	32140	79651853
Maternal exposure during pregnancy	11.32	10.82	59	60336	136479	79547514
Urinary tract infection	11.31	10.82	280	60115	274232	79409761
Complication associated with device	11.29	10.82	34	60361	17462	79666531
Amyloidosis	11.26	10.82	12	60383	2694	79681299
Drug eruption	11.26	10.82	10	60385	43925	79640068
Renal lymphocele	11.13	10.82	4	60391	119	79683874
Staphylococcal infection	11.13	10.82	79	60316	58216	79625777
Klebsiella sepsis	11.09	10.82	13	60382	3239	79680754
Polycythaemia	11.08	10.82	11	60384	2273	79681720
Chronic hepatitis	11.05	10.82	9	60386	1438	79682555
Surgical procedure repeated	11.03	10.82	7	60388	757	79683236
Hallucination	11.03	10.82	31	60364	85714	79598279
Paroxysmal nocturnal haemoglobinuria	10.90	10.82	5	60390	282	79683711
Plasmacytoma	10.89	10.82	15	60380	4388	79679605
Parvovirus B19 infection	10.87	10.82	9	60386	1471	79682522

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B03XA01	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS OTHER ANTIANEMIC PREPARATIONS Other antianemic preparations
FDA CS	M0007726	Erythropoietin
FDA PE	N0000009319	Increased Erythroid Cell Production
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents
FDA EPC	N0000175665	Erythropoiesis-stimulating Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anemia due to chemotherapy	indication	429564000
Anemia in chronic kidney disease	indication	707323002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Erythropoietin receptor	Membrane receptor	P19235	EPOR_HUMAN	AGONIST	IC50	11.15		IUPHAR	DRUG LABEL

External reference:

ID	Source
D03231	KEGG_DRUG
4019505	VUID
N0000147625	NUI
4019505	VANDF
4037607	VANDF
CHEMBL1201565	ChEMBL_ID
DB00016	DRUGBANK_ID
105694	RXNORM
34327	MMSL
3530	MMSL
4668	MMSL
866	MMSL
d00223	MMSL
003439	NDDF
017553	NDDF
108964008	SNOMEDCT_US
386947003	SNOMEDCT_US
83042003	SNOMEDCT_US
D000068817	MESH_DESCRIPTOR_UI
D004921	MESH_DESCRIPTOR_UI
C0357126	UMLSCUI
CHEMBL2109092	ChEMBL_ID
CHEMBL2108593	ChEMBL_ID
92043599	PUBCHEM_CID
11096-26-7	SECONDARY_CAS_RN
4921	IUPHAR_LIGAND_ID

Pharmaceutical products:

None