epoetin alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
erythropoietin type blood factors 4995 113427-24-0

Description:

MoleculeDescription

Synonyms:

  • epoetin alfa-epbx
  • epoetin alfa
  • epogen
  • procrit
  • epoetin alfa (genetical recombination)
  • erythropoietin
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1 TU P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 1, 1989 FDA AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemoglobin decreased 807.91 12.23 657 44283 161299 90422208
Aplasia pure red cell 797.33 12.23 228 44712 4966 90578541
Death 649.13 12.23 953 43987 455598 90127909
Nephrogenic systemic fibrosis 544.87 12.23 161 44779 3947 90579560
Anaemia 444.48 12.23 697 44243 352105 90231402
Product storage error 361.57 12.23 184 44756 20057 90563450
Therapeutic response decreased 247.55 12.23 262 44678 89467 90494040
Anti-erythropoietin antibody positive 239.66 12.23 52 44888 334 90583173
Peritonitis bacterial 215.23 12.23 85 44855 5086 90578421
Skin induration 206.77 12.23 73 44867 3189 90580318
Anti-erythropoietin antibody negative 184.94 12.23 35 44905 97 90583410
Haemoglobin abnormal 179.73 12.23 82 44858 7018 90576489
Thrombocytopenia 173.31 12.23 344 44596 208381 90375126
Shunt stenosis 164.16 12.23 41 44899 518 90582989
Skin hypertrophy 163.17 12.23 63 44877 3547 90579960
Pancytopenia 150.00 12.23 237 44703 120026 90463481
Peritonitis 135.50 12.23 97 44843 19608 90563899
Haematocrit decreased 135.02 12.23 133 44807 41699 90541808
Glossodynia 130.94 12.23 7 44933 321772 90261735
Skin tightness 130.12 12.23 57 44883 4431 90579076
Renal failure 129.87 12.23 233 44707 130774 90452733
Synovitis 128.68 12.23 9 44931 329743 90253764
Drug intolerance 124.56 12.23 34 44906 447557 90135950
Sepsis 122.03 12.23 273 44667 179541 90403966
Peritoneal dialysis complication 121.61 12.23 39 44901 1263 90582244
Platelet count decreased 118.76 12.23 230 44710 136739 90446768
Arthropathy 117.78 12.23 20 44920 366222 90217285
Systemic lupus erythematosus 115.85 12.23 20 44920 361876 90221631
Cardio-respiratory arrest 111.80 12.23 147 44793 62993 90520514
Contraindicated product administered 110.99 12.23 14 44926 320125 90263382
Joint swelling 108.81 12.23 57 44883 503243 90080264
Rheumatoid arthritis 107.75 12.23 24 44916 362590 90220917
Plasma cell myeloma 106.84 12.23 116 44824 40712 90542795
Hepatic enzyme increased 103.00 12.23 26 44914 360710 90222797
Myelodysplastic syndrome 102.18 12.23 84 44856 20819 90562688
Pericarditis 100.83 12.23 9 44931 270142 90313365
Helicobacter infection 95.27 12.23 4 44936 226846 90356661
Neutropenia 95.21 12.23 286 44654 224618 90358889
Skin fibrosis 92.89 12.23 29 44911 859 90582648
Treatment failure 92.56 12.23 19 44921 303909 90279598
Reticulocyte count decreased 91.91 12.23 25 44915 449 90583058
Fibrosis 91.64 12.23 49 44891 5903 90577604
Abdominal discomfort 90.64 12.23 63 44877 477265 90106242
Infusion related reaction 88.87 12.23 48 44892 416732 90166775
Folliculitis 87.88 12.23 3 44937 204350 90379157
Dialysis 87.76 12.23 60 44880 11269 90572238
Chronic kidney disease 87.53 12.23 116 44824 50075 90533432
Irritable bowel syndrome 85.99 12.23 4 44936 207444 90376063
Fibromyalgia 85.43 12.23 4 44936 206265 90377242
Hyperparathyroidism 82.76 12.23 38 44902 3299 90580208
Asthenia 80.80 12.23 496 44444 533255 90050252
Drug ineffective 80.41 12.23 384 44556 1383914 89199593
Sinusitis 79.99 12.23 35 44905 343053 90240454
Wound 78.80 12.23 26 44914 302954 90280553
Drug hypersensitivity 78.14 12.23 69 44871 463540 90119967
Arteriovenous fistula site complication 76.55 12.23 22 44918 487 90583020
Bone marrow failure 76.48 12.23 87 44853 32134 90551373
Calciphylaxis 76.15 12.23 36 44904 3340 90580167
Therapeutic product effect decreased 73.64 12.23 23 44917 277548 90305959
Hypervolaemia 73.63 12.23 86 44854 32671 90550836
Hospitalisation 73.26 12.23 182 44758 127918 90455589
Oedema peripheral 73.16 12.23 287 44653 257628 90325879
Cardiac failure 71.72 12.23 164 44776 109332 90474175
Liver injury 71.64 12.23 3 44937 170564 90412943
Acute myocardial infarction 70.87 12.23 87 44853 34803 90548704
Product use issue 70.30 12.23 38 44902 329881 90253626
Blood cholesterol increased 69.91 12.23 10 44930 208002 90375505
Cardiac failure congestive 69.32 12.23 152 44788 98542 90484965
Alopecia 68.52 12.23 87 44853 494984 90088523
Athetosis 67.32 12.23 14 44926 71 90583436
Serum ferritin increased 66.62 12.23 43 44897 7338 90576169
White blood cell count decreased 63.72 12.23 205 44735 166904 90416603
Haematocrit abnormal 63.47 12.23 23 44917 1084 90582423
Type 2 diabetes mellitus 63.33 12.23 12 44928 203232 90380275
Refractory cytopenia with unilineage dysplasia 62.01 12.23 19 44921 528 90582979
Sleep disorder 61.06 12.23 12 44928 198018 90385489
Transfusion 60.92 12.23 58 44882 17430 90566077
Renal transplant 60.76 12.23 25 44915 1663 90581844
Swelling 60.76 12.23 71 44869 418987 90164520
Deep vein thrombosis 59.74 12.23 137 44803 91483 90492024
Asthma 59.17 12.23 23 44917 242137 90341370
Blood creatinine increased 58.96 12.23 145 44795 101241 90482266
Full blood count decreased 58.64 12.23 73 44867 29616 90553891
Headache 58.05 12.23 226 44714 862520 89720987
Discomfort 57.85 12.23 32 44908 274303 90309204
Lower respiratory tract infection 57.72 12.23 26 44914 250633 90332874
Premature delivery 57.68 12.23 83 44857 38679 90544828
Ill-defined disorder 55.35 12.23 12 44928 184879 90398628
Skin hyperpigmentation 54.76 12.23 37 44903 6814 90576693
Red blood cell count decreased 54.52 12.23 89 44851 46262 90537245
Intentional product use issue 53.99 12.23 20 44920 216872 90366635
Joint contracture 53.61 12.23 23 44917 1699 90581808
Arthralgia 53.59 12.23 202 44738 778320 89805187
Therapeutic product effect incomplete 53.35 12.23 15 44925 193881 90389626
Drug specific antibody absent 51.84 12.23 12 44928 107 90583400
Nasopharyngitis 51.80 12.23 76 44864 407028 90176479
Shunt occlusion 51.63 12.23 18 44922 757 90582750
Diabetic foot 51.49 12.23 22 44918 1609 90581898
Impaired healing 51.31 12.23 26 44914 234173 90349334
Cerebrovascular accident 51.18 12.23 156 44784 123377 90460130
Metabolic encephalopathy 50.50 12.23 35 44905 6717 90576790
Wheezing 49.86 12.23 28 44912 238052 90345455
Hypotension 49.51 12.23 303 44637 325094 90258413
Diffuse large B-cell lymphoma refractory 49.40 12.23 22 44918 1778 90581729
Neutralising antibodies positive 48.21 12.23 14 44926 322 90583185
Bursitis 47.48 12.23 5 44935 131649 90451858
Iron overload 46.72 12.23 18 44922 1007 90582500
Haemodialysis 46.66 12.23 37 44903 8710 90574797
Dehydration 46.18 12.23 205 44735 194242 90389265
C-reactive protein abnormal 45.54 12.23 5 44935 127424 90456083
Renal impairment 45.43 12.23 135 44805 105286 90478221
Fungal peritonitis 43.02 12.23 15 44925 631 90582876
Blister 42.85 12.23 38 44902 254960 90328547
Condition aggravated 41.93 12.23 153 44787 595392 89988115
Blood product transfusion dependent 41.34 12.23 11 44929 181 90583326
Fryns syndrome 41.19 12.23 9 44931 60 90583447
Urticaria 41.13 12.23 57 44883 312677 90270830
Cerebellar stroke 40.83 12.23 13 44927 411 90583096
Septic shock 40.36 12.23 112 44828 84048 90499459
Psoriasis 39.60 12.23 12 44928 147742 90435765
Oesophageal atresia 39.55 12.23 14 44926 616 90582891
Disease progression 39.38 12.23 168 44772 156447 90427060
Hyperkalaemia 38.92 12.23 94 44846 64870 90518637
Blood iron increased 38.47 12.23 19 44921 1940 90581567
Haemorrhoidal haemorrhage 38.43 12.23 27 44913 5296 90578211
Musculoskeletal stiffness 38.05 12.23 55 44885 296477 90287030
Congenital nail disorder 37.51 12.23 9 44931 95 90583412
Bone pain 37.47 12.23 90 44850 61893 90521614
Hyperparathyroidism secondary 36.96 12.23 18 44922 1783 90581724
Blood urea increased 36.59 12.23 59 44881 30354 90553153
Acute kidney injury 36.58 12.23 278 44662 320109 90263398
Migraine 36.24 12.23 25 44915 190367 90393140
Kidney transplant rejection 35.91 12.23 25 44915 4832 90578675
Urinary tract infection 35.91 12.23 267 44673 305365 90278142
Peritoneal cloudy effluent 35.85 12.23 11 44929 307 90583200
Atrial fibrillation 35.68 12.23 146 44794 133465 90450042
Peritoneal dialysis 35.19 12.23 12 44928 472 90583035
Blood potassium increased 34.70 12.23 47 44893 20702 90562805
Congenital diaphragmatic hernia 34.51 12.23 10 44930 228 90583279
Product use in unapproved indication 34.37 12.23 72 44868 336164 90247343
Stomatitis 34.22 12.23 52 44888 274646 90308861
Ultrafiltration failure 33.16 12.23 10 44930 263 90583244
Neuropathy peripheral 32.96 12.23 145 44795 136825 90446682
Malnutrition 32.51 12.23 43 44897 18515 90564992
Endometrial disorder 32.44 12.23 13 44927 808 90582699
Pseudomonal bacteraemia 32.35 12.23 17 44923 1977 90581530
Grip strength decreased 32.16 12.23 4 44936 92572 90490935
Expired product administered 32.13 12.23 27 44913 6895 90576612
Toxicity to various agents 31.69 12.23 59 44881 287787 90295720
Mental status changes 31.57 12.23 69 44871 44610 90538897
Sciatica 31.54 12.23 6 44934 101376 90482131
Soft tissue infection 31.50 12.23 19 44921 2878 90580629
Akathisia 31.47 12.23 33 44907 11126 90572381
Hypercholesterolaemia 31.33 12.23 6 44934 100886 90482621
Liver function test increased 31.17 12.23 3 44937 84852 90498655
Blood albumin decreased 31.09 12.23 40 44900 16763 90566744
Haemorrhoids 31.03 12.23 51 44889 26651 90556856
Blood parathyroid hormone increased 30.96 12.23 20 44920 3417 90580090
Scar 30.63 12.23 38 44902 15357 90568150
Peripheral swelling 30.46 12.23 104 44836 413002 90170505
Knee arthroplasty 30.40 12.23 3 44937 83179 90500328
Red blood cell sedimentation rate increased 30.13 12.23 3 44937 82592 90500915
Product administration error 30.08 12.23 50 44890 26373 90557134
Pulmonary hypoplasia 29.98 12.23 10 44930 367 90583140
Intensive care unit acquired weakness 29.82 12.23 13 44927 998 90582509
Microtia 29.38 12.23 10 44930 391 90583116
Pneumonia 29.15 12.23 461 44479 637598 89945909
Splenomegaly 29.15 12.23 34 44906 12890 90570617
Non-neutralising antibodies positive 29.11 12.23 5 44935 6 90583501
Drug-induced liver injury 28.84 12.23 5 44935 90313 90493194
Haemolytic anaemia 28.46 12.23 32 44908 11665 90571842
Pain 28.41 12.23 337 44603 996004 89587503
Weight increased 28.31 12.23 109 44831 417818 90165689
Wound infection 27.87 12.23 9 44931 106393 90477114
Maternal exposure during pregnancy 27.67 12.23 89 44851 359974 90223533
Drug abuse 27.56 12.23 4 44936 82343 90501164
Obesity 27.50 12.23 9 44931 105498 90478009
Haemolysis 27.34 12.23 27 44913 8483 90575024
Porphyria 26.91 12.23 8 44932 200 90583307
Memory impairment 26.88 12.23 35 44905 197209 90386298
Extremity contracture 26.77 12.23 13 44927 1280 90582227
Road traffic accident 26.64 12.23 10 44930 107616 90475891
Complications of transplanted kidney 26.55 12.23 17 44923 2861 90580646
Enterococcus test positive 26.43 12.23 13 44927 1316 90582191
Full blood count abnormal 26.40 12.23 57 44883 36540 90546967
Peau d'orange 26.10 12.23 7 44933 119 90583388
Peripheral venous disease 26.03 12.23 5 44935 83916 90499591
C-reactive protein increased 25.96 12.23 31 44909 181358 90402149
Dry mouth 25.77 12.23 32 44908 184027 90399480
Toxoplasmosis 25.54 12.23 14 44926 1771 90581736
Haemorrhage 25.42 12.23 84 44856 69285 90514222
Osteoarthritis 25.39 12.23 36 44904 195694 90387813
Heparin-induced thrombocytopenia 25.23 12.23 21 44919 5291 90578216
Gastrointestinal haemorrhage 25.19 12.23 100 44840 90148 90493359
Autoimmune disorder 25.06 12.23 4 44936 76740 90506767
Transferrin saturation increased 24.95 12.23 6 44934 64 90583443
Intercepted product administration error 24.72 12.23 11 44929 887 90582620
Metabolic acidosis 24.65 12.23 72 44868 55604 90527903
Suicide attempt 24.46 12.23 4 44936 75395 90508112
Ascites 24.35 12.23 65 44875 47675 90535832
Epistaxis 24.31 12.23 95 44845 85030 90498477
Diarrhoea 24.27 12.23 623 44317 938567 89644940
Vulvovaginal mycotic infection 24.03 12.23 22 44918 6292 90577215
Anhedonia 24.01 12.23 29 44911 11402 90572105
Transfusion reaction 23.89 12.23 12 44928 1270 90582237
Reticulocyte count abnormal 23.86 12.23 6 44934 78 90583429
Leukopenia 23.75 12.23 106 44834 100604 90482903
Unresponsive to stimuli 23.74 12.23 56 44884 38065 90545442
Delirium 23.73 12.23 11 44929 104348 90479159
Tracheo-oesophageal fistula 23.60 12.23 10 44930 716 90582791
Pleural effusion 23.56 12.23 114 44826 111877 90471630
Arthritis 23.52 12.23 29 44911 167286 90416221
Chorea 23.36 12.23 14 44926 2096 90581411
Immunosuppressant drug level increased 23.27 12.23 19 44921 4661 90578846
Low birth weight baby 23.20 12.23 26 44914 9441 90574066
Marrow hyperplasia 23.18 12.23 10 44930 749 90582758
Hyperuricaemia 22.86 12.23 22 44918 6697 90576810
Neoplasm skin 22.83 12.23 16 44924 3126 90580381
Hip arthroplasty 22.69 12.23 5 44935 76203 90507304
Blood phosphorus increased 22.47 12.23 18 44922 4300 90579207
Myocardial infarction 22.39 12.23 108 44832 105864 90477643
Cardiac ventricular thrombosis 22.27 12.23 11 44929 1123 90582384
Skin discolouration 22.26 12.23 60 44880 44255 90539252
Craniocervical syndrome 22.26 12.23 6 44934 104 90583403
Failure to thrive 22.17 12.23 24 44916 8387 90575120
Cerebrovascular disorder 22.06 12.23 15 44925 2791 90580716
Parvovirus B19 test positive 21.89 12.23 6 44934 111 90583396
Refusal of treatment by patient 21.85 12.23 20 44920 5718 90577789
Night sweats 21.84 12.23 19 44921 128747 90454760
Coarctation of the aorta 21.64 12.23 9 44931 615 90582892
Epilepsy 21.44 12.23 7 44933 82199 90501308
Iron deficiency 21.20 12.23 25 44915 9587 90573920
Peripheral sensorimotor neuropathy 21.18 12.23 13 44927 2032 90581475
Micturition disorder 21.06 12.23 15 44925 3005 90580502
Skin mass 21.00 12.23 22 44918 7408 90576099
Multiple organ dysfunction syndrome 20.94 12.23 78 44862 68258 90515249
Clostridium difficile colitis 20.90 12.23 43 44897 26663 90556844
Loss of personal independence in daily activities 20.85 12.23 22 44918 136083 90447424
Emotional distress 20.84 12.23 52 44888 36610 90546897
Red blood cell count abnormal 20.77 12.23 11 44929 1300 90582207
Pulmonary fibrosis 20.61 12.23 14 44926 107489 90476018
Cardiomegaly 20.46 12.23 35 44905 18890 90564617
Liver disorder 20.44 12.23 18 44922 121251 90462256
Graft infection 20.44 12.23 7 44933 279 90583228
Generalised oedema 20.29 12.23 35 44905 19018 90564489
Lung disorder 20.01 12.23 27 44913 149856 90433651
Blood erythropoietin abnormal 19.83 12.23 3 44937 0 90583507
Foot deformity 19.72 12.23 3 44937 59648 90523859
Acute pulmonary oedema 19.63 12.23 24 44916 9556 90573951
Leg amputation 19.59 12.23 13 44927 2324 90581183
Acute myeloid leukaemia 19.52 12.23 36 44904 20604 90562903
Azotaemia 19.13 12.23 18 44922 5330 90578177
Haemoglobin increased 19.12 12.23 21 44919 7460 90576047
Respiratory failure 19.07 12.23 112 44828 118306 90465201
Craniofacial deformity 19.05 12.23 6 44934 183 90583324
Febrile neutropenia 18.95 12.23 139 44801 158210 90425297
Bone marrow disorder 18.74 12.23 14 44926 3018 90580489
Congestive hepatopathy 18.74 12.23 14 44926 3019 90580488
Hyperphosphataemia 18.32 12.23 15 44925 3696 90579811
Peripheral ischaemia 18.24 12.23 18 44922 5649 90577858
Musculoskeletal pain 18.05 12.23 36 44904 171215 90412292
Cardiac arrest 18.05 12.23 101 44839 104834 90478673
Hypocalcaemia 18.00 12.23 54 44886 42314 90541193
Syncope 17.95 12.23 120 44820 132543 90450964
Cleft palate 17.95 12.23 10 44930 1306 90582201
Gingival hypertrophy 17.87 12.23 12 44928 2188 90581319
Sickle cell anaemia with crisis 17.82 12.23 20 44920 7277 90576230
Renal disorder 17.76 12.23 50 44890 37809 90545698
Blood erythropoietin decreased 17.75 12.23 3 44937 3 90583504
Conjunctival discolouration 17.74 12.23 5 44935 103 90583404
Injection site reaction 17.64 12.23 12 44928 92068 90491439
Overdose 17.63 12.23 32 44908 157677 90425830
Arteriovenous fistula site haemorrhage 17.57 12.23 6 44934 237 90583270
Erythema infectiosum 17.56 12.23 5 44935 107 90583400
Transient ischaemic attack 17.38 12.23 54 44886 43122 90540385
Injection site erythema 17.36 12.23 14 44926 98488 90485019
Myocardial oedema 17.33 12.23 7 44933 444 90583063
Skin plaque 17.30 12.23 23 44917 9952 90573555
Insomnia 17.21 12.23 96 44844 333378 90250129
Myelopathy 17.16 12.23 14 44926 3430 90580077
Electrolyte imbalance 17.15 12.23 37 44903 23708 90559799
Iron binding capacity total decreased 17.11 12.23 7 44933 459 90583048
Vascular parkinsonism 16.94 12.23 5 44935 122 90583385
Anti-erythropoietin antibody 16.89 12.23 3 44937 5 90583502
Hypertensive crisis 16.80 12.23 31 44909 17753 90565754
Thrombocytosis 16.77 12.23 19 44921 6982 90576525
Biopsy bone marrow abnormal 16.74 12.23 6 44934 274 90583233
Premature rupture of membranes 16.69 12.23 17 44923 5541 90577966
Dyspepsia 16.63 12.23 47 44893 198113 90385394
Leukocytosis 16.62 12.23 43 44897 30947 90552560
Endocarditis 16.53 12.23 19 44921 7094 90576413
Vascular calcification 16.51 12.23 8 44932 784 90582723
Hepatitis C 16.43 12.23 17 44923 5643 90577864
Ear infection 16.42 12.23 7 44933 69768 90513739
Thrombosis in device 16.39 12.23 13 44927 3062 90580445
Myelofibrosis 16.33 12.23 10 44930 1557 90581950
Pulmonary embolism 16.32 12.23 116 44824 130704 90452803
Device related infection 16.18 12.23 38 44902 25748 90557759
Amnesia 16.11 12.23 18 44922 108487 90475020
Constipation 16.11 12.23 211 44729 280184 90303323
Hypersensitivity 16.09 12.23 146 44794 454531 90128976
Folate deficiency 16.06 12.23 13 44927 3152 90580355
Disease complication 16.05 12.23 14 44926 3758 90579749
Normochromic normocytic anaemia 16.04 12.23 16 44924 5086 90578421
Colitis ulcerative 15.95 12.23 5 44935 60261 90523246
Abdominal pain 15.85 12.23 280 44660 395441 90188066
Premature baby 15.79 12.23 37 44903 25040 90558467
Thrombosis 15.72 12.23 75 44865 73176 90510331
Arteriovenous graft site haemorrhage 15.68 12.23 3 44937 9 90583498
Arteriovenous graft site infection 15.68 12.23 3 44937 9 90583498
Therapeutic drug monitoring analysis incorrectly performed 15.58 12.23 6 44934 335 90583172
Peripheral arterial occlusive disease 15.48 12.23 15 44925 4606 90578901
Nail disorder 15.46 12.23 5 44935 59062 90524445
Posterior reversible encephalopathy syndrome 15.21 12.23 34 44906 22305 90561202
Retinal artery occlusion 15.20 12.23 11 44929 2260 90581247
Renal lymphocele 15.02 12.23 4 44936 66 90583441
Renal atrophy 14.82 12.23 10 44930 1838 90581669
Osteolysis 14.75 12.23 13 44927 3537 90579970
Streptococcal sepsis 14.65 12.23 13 44927 3571 90579936
Lethargy 14.54 12.23 66 44874 63073 90520434
Systemic inflammatory response syndrome 14.46 12.23 17 44923 6499 90577008
Nephrogenic anaemia 14.39 12.23 11 44929 2455 90581052
Haemosiderosis 14.37 12.23 5 44935 209 90583298
Decubitus ulcer 14.32 12.23 23 44917 11790 90571717
Gastrooesophageal reflux disease 14.29 12.23 39 44901 166298 90417209
Enterococcal infection 14.29 12.23 21 44919 9970 90573537
Illness 14.02 12.23 12 44928 81957 90501550
Adenocarcinoma metastatic 14.00 12.23 5 44935 226 90583281
Dysmorphism 13.99 12.23 11 44929 2557 90580950
Cardiorenal syndrome 13.95 12.23 8 44932 1104 90582403
Renal injury 13.89 12.23 21 44919 10222 90573285
Staphylococcal infection 13.78 12.23 54 44886 48385 90535122
Dermatitis bullous 13.78 12.23 21 44919 10295 90573212
Inappropriate schedule of product administration 13.76 12.23 34 44906 149899 90433608
Acute chest syndrome 13.71 12.23 8 44932 1140 90582367
End stage renal disease 13.71 12.23 19 44921 8552 90574955
Uterine dilation and evacuation 13.60 12.23 3 44937 21 90583486
Henoch-Schonlein purpura 13.52 12.23 9 44931 1618 90581889
Heart disease congenital 13.41 12.23 9 44931 1640 90581867
Vomiting 13.38 12.23 497 44443 787796 89795711
Dialysis device insertion 13.36 12.23 3 44937 23 90583484
Cognitive disorder 13.35 12.23 9 44931 69398 90514109
Vasculitic ulcer 13.33 12.23 5 44935 260 90583247
Polycythaemia 13.24 12.23 8 44932 1215 90582292
Therapeutic response delayed 13.09 12.23 7 44933 843 90582664
Exostosis 13.04 12.23 5 44935 53129 90530378
Mobility decreased 13.03 12.23 72 44868 250662 90332845
Injury 13.00 12.23 52 44888 197297 90386210
Bone erosion 13.00 12.23 5 44935 53016 90530491
Hip fracture 12.97 12.23 41 44899 33036 90550471
Injection site extravasation 12.96 12.23 19 44921 9000 90574507
Red blood cell abnormality 12.96 12.23 6 44934 531 90582976
Frequent bowel movements 12.95 12.23 6 44934 56929 90526578
Infection 12.92 12.23 116 44824 361978 90221529
Adverse drug reaction 12.76 12.23 24 44916 116677 90466830
Lower limb fracture 12.73 12.23 14 44926 84999 90498508
Injection site swelling 12.57 12.23 7 44933 59832 90523675
Hypoglycaemia 12.52 12.23 68 44872 69780 90513727
Procedural complication 12.49 12.23 15 44925 5863 90577644
Confusional state 12.39 12.23 127 44813 386078 90197429
Blood calcium decreased 12.38 12.23 38 44902 30144 90553363
Ecchymosis 12.30 12.23 22 44918 12301 90571206
Hepatitis cholestatic 12.25 12.23 18 44922 8543 90574964

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aplasia pure red cell 806.83 12.01 291 40593 6875 42573576
Haemoglobin decreased 556.26 12.01 659 40225 131812 42448639
Therapeutic response decreased 413.48 12.01 317 40567 36695 42543756
Nephrogenic systemic fibrosis 389.55 12.01 141 40743 3360 42577091
Anti-erythropoietin antibody positive 298.57 12.01 83 40801 799 42579652
Anaemia 247.80 12.01 707 40177 279571 42300880
Product storage error 223.38 12.01 137 40747 11003 42569448
Death 199.54 12.01 935 39949 470250 42110201
Skin induration 171.87 12.01 66 40818 1861 42578590
Haemoglobin abnormal 147.73 12.01 79 40805 4885 42575566
Peritonitis bacterial 130.90 12.01 82 40802 6833 42573618
Skin hypertrophy 117.02 12.01 56 40828 2733 42577718
Myelodysplastic syndrome 115.15 12.01 125 40759 22620 42557831
Skin tightness 110.18 12.01 50 40834 2160 42578291
Shunt stenosis 104.35 12.01 36 40848 741 42579710
Reticulocyte count decreased 99.89 12.01 34 40850 671 42579780
Device interaction 97.91 12.01 32 40852 554 42579897
Toxicity to various agents 93.19 12.01 52 40832 229084 42351367
Anti-erythropoietin antibody negative 91.74 12.01 24 40860 179 42580272
Plasma cell myeloma 87.77 12.01 161 40723 47417 42533034
Renal transplant 84.78 12.01 43 40841 2382 42578069
Skin fibrosis 82.90 12.01 32 40852 915 42579536
Peritoneal dialysis complication 81.79 12.01 39 40845 1888 42578563
Joint contracture 77.20 12.01 39 40845 2142 42578309
Drug interaction 72.33 12.01 90 40794 266909 42313542
Chronic kidney disease 71.43 12.01 147 40737 47094 42533357
IVth nerve paralysis 70.24 12.01 25 40859 566 42579885
Dialysis 64.40 12.01 68 40816 11918 42568533
Pancytopenia 64.23 12.01 253 40631 117490 42462961
Refractory cytopenia with unilineage dysplasia 61.69 12.01 22 40862 501 42579950
Peritonitis 60.84 12.01 82 40802 18551 42561900
Shunt occlusion 60.09 12.01 26 40858 1001 42579450
Platelet count decreased 58.82 12.01 276 40608 138305 42442146
Serum ferritin increased 57.78 12.01 51 40833 7168 42573283
Joint range of motion decreased 56.59 12.01 52 40832 7701 42572750
Fibrosis 52.54 12.01 34 40850 2996 42577455
Extremity contracture 49.68 12.01 21 40863 763 42579688
Asthenia 48.66 12.01 446 40438 280347 42300104
Cardio-respiratory arrest 47.71 12.01 144 40740 58492 42521959
Iron overload 47.28 12.01 25 40859 1510 42578941
Diabetic foot 47.27 12.01 32 40852 3041 42577410
Scar 47.15 12.01 44 40840 6644 42573807
IgA nephropathy 47.07 12.01 29 40855 2345 42578106
Product use in unapproved indication 47.00 12.01 65 40819 184391 42396060
Nephrogenic anaemia 44.79 12.01 29 40855 2557 42577894
Blood iron increased 44.46 12.01 21 40863 995 42579456
Thrombocytopenia 44.13 12.01 323 40561 189956 42390495
Oedema peripheral 43.83 12.01 251 40633 135825 42444626
Neutralising antibodies positive 43.11 12.01 12 40872 116 42580335
Acute myocardial infarction 40.16 12.01 135 40749 58030 42522421
Deformity 38.09 12.01 22 40862 1580 42578871
Non-neutralising antibodies positive 37.72 12.01 10 40874 79 42580372
Bone marrow failure 37.68 12.01 92 40792 33001 42547450
Marrow hyperplasia 36.94 12.01 20 40864 1267 42579184
Febrile bone marrow aplasia 36.63 12.01 47 40837 10134 42570317
Drug ineffective 35.40 12.01 411 40473 629786 41950665
Peau d'orange 35.36 12.01 10 40874 103 42580348
Blood product transfusion dependent 35.05 12.01 14 40870 439 42580012
Blood parathyroid hormone increased 34.34 12.01 22 40862 1905 42578546
Intentional product use issue 34.26 12.01 13 40871 71820 42508631
Transfusion 33.91 12.01 46 40838 10468 42569983
Blood iron abnormal 33.75 12.01 10 40874 123 42580328
Hospitalisation 33.69 12.01 151 40733 74179 42506272
Anhedonia 33.54 12.01 39 40845 7601 42572850
Haemodialysis 33.26 12.01 45 40839 10215 42570236
Blood erythropoietin increased 32.76 12.01 7 40877 18 42580433
Hyperparathyroidism secondary 32.75 12.01 21 40863 1821 42578630
Haematocrit decreased 32.51 12.01 90 40794 34818 42545633
Haemoglobin increased 32.44 12.01 32 40852 5174 42575277
Hyperparathyroidism 31.32 12.01 18 40866 1281 42579170
Red blood cell count decreased 31.11 12.01 85 40799 32630 42547821
Blood urea increased 30.99 12.01 85 40799 32708 42547743
Splenomegaly 29.31 12.01 56 40828 16991 42563460
Cardiac failure congestive 28.92 12.01 160 40724 85442 42495009
Renal failure 28.31 12.01 235 40649 143491 42436960
Hypervolaemia 28.17 12.01 66 40818 23059 42557392
Calciphylaxis 27.60 12.01 16 40868 1157 42579294
Weight increased 27.53 12.01 38 40846 107945 42472506
Reticulocytopenia 26.76 12.01 9 40875 171 42580280
Intentional product misuse 26.66 12.01 13 40871 61887 42518564
Cellulitis enterococcal 26.52 12.01 8 40876 105 42580346
Suicidal ideation 26.01 12.01 7 40877 48154 42532297
Transferrin saturation increased 25.48 12.01 8 40876 121 42580330
Rheumatoid arthritis 25.24 12.01 5 40879 42435 42538016
Acquired haemophilia 24.71 12.01 17 40867 1658 42578793
Arteriovenous fistula operation 24.29 12.01 8 40876 142 42580309
Parvovirus B19 test positive 24.24 12.01 8 40876 143 42580308
Cerebrovascular accident 23.67 12.01 167 40717 96993 42483458
Kidney transplant rejection 23.58 12.01 35 40849 8648 42571803
Rhabdomyolysis 23.58 12.01 24 40860 77995 42502456
Noninfectious peritonitis 23.35 12.01 8 40876 161 42580290
Incision site pain 22.76 12.01 17 40867 1886 42578565
Asthma 22.71 12.01 16 40868 62298 42518153
Haemolytic anaemia 22.29 12.01 41 40843 12086 42568365
Ultrafiltration failure 21.82 12.01 9 40875 307 42580144
Drug-induced liver injury 21.76 12.01 5 40879 38268 42542183
Malnutrition 21.67 12.01 45 40839 14497 42565954
Treatment failure 21.64 12.01 17 40867 62607 42517844
Reticulocyte count increased 21.53 12.01 12 40872 805 42579646
Pleural effusion 21.37 12.01 163 40721 97003 42483448
Erythropoiesis abnormal 21.11 12.01 9 40875 334 42580117
Stress 21.08 12.01 8 40876 44204 42536247
Emotional distress 20.78 12.01 47 40837 16046 42564405
Azotaemia 20.69 12.01 27 40857 5917 42574534
Condition aggravated 20.59 12.01 156 40728 260598 42319853
Haematocrit abnormal 20.37 12.01 12 40872 894 42579557
Therapeutic response delayed 20.15 12.01 11 40873 708 42579743
Therapeutic product effect incomplete 20.12 12.01 23 40861 70916 42509535
Transferrin saturation decreased 20.12 12.01 10 40874 530 42579921
Renal disorder 19.76 12.01 67 40817 28913 42551538
Neutropenia 19.62 12.01 284 40600 199147 42381304
Skin hyperpigmentation 19.46 12.01 22 40862 4159 42576292
Aggression 19.44 12.01 9 40875 44154 42536297
Nasopharyngitis 19.05 12.01 32 40852 83964 42496487
Morganella infection 18.83 12.01 10 40874 609 42579842
Interstitial lung disease 18.63 12.01 29 40855 78433 42502018
Deep vein thrombosis 18.58 12.01 132 40752 76825 42503626
Iron binding capacity total decreased 18.51 12.01 7 40877 189 42580262
Inadequate osteointegration 18.27 12.01 4 40880 12 42580439
Drug dependence 18.23 12.01 3 40881 29091 42551360
Overdose 18.07 12.01 47 40837 105217 42475234
Renal ischaemia 17.95 12.01 14 40870 1656 42578795
Expired product administered 17.86 12.01 21 40863 4142 42576309
Transferrin abnormal 17.85 12.01 3 40881 0 42580451
Iron binding capacity total abnormal 17.85 12.01 3 40881 0 42580451
Bronchial haemorrhage 17.63 12.01 10 40874 694 42579757
Headache 17.59 12.01 146 40738 239223 42341228
Therapy non-responder 17.52 12.01 99 40785 53260 42527191
Shunt infection 17.32 12.01 6 40878 125 42580326
Dependence on oxygen therapy 17.31 12.01 7 40877 227 42580224
Staphylococcal bacteraemia 17.26 12.01 35 40849 11086 42569365
Agitation 17.03 12.01 22 40862 64292 42516159
Drug intolerance 17.01 12.01 32 40852 80392 42500059
Blood creatinine increased 16.64 12.01 170 40714 109833 42470618
Complications of transplanted kidney 16.64 12.01 23 40861 5327 42575124
Right ventricular dilatation 16.52 12.01 10 40874 783 42579668
Iron deficiency 16.21 12.01 34 40850 11027 42569424
Peritoneal dialysis 16.17 12.01 9 40875 602 42579849
Dental restoration failure 16.04 12.01 4 40880 24 42580427
Bone marrow reticulin fibrosis 16.01 12.01 6 40878 158 42580293
Erythema infectiosum 15.97 12.01 6 40878 159 42580292
Hallucination 15.93 12.01 19 40865 57488 42522963
Infusion related reaction 15.89 12.01 21 40863 60785 42519666
Product use issue 15.83 12.01 31 40853 76720 42503731
Psoriasis 15.79 12.01 14 40870 48590 42531861
Haemochromatosis 15.74 12.01 11 40873 1101 42579350
Biopsy bone marrow abnormal 15.67 12.01 7 40877 291 42580160
Reticulocyte count abnormal 15.64 12.01 4 40880 27 42580424
Inappropriate schedule of product administration 15.57 12.01 44 40840 95858 42484593
Somnolence 15.53 12.01 76 40808 141029 42439422
Sleep disorder 15.45 12.01 14 40870 48081 42532370
Hepatic function abnormal 15.42 12.01 16 40868 51551 42528900
Loss of personal independence in daily activities 15.42 12.01 15 40869 49801 42530650
Migraine 15.10 12.01 3 40881 25411 42555040
Parathyroidectomy 14.96 12.01 5 40879 93 42580358
Hypocalcaemia 14.96 12.01 63 40821 30110 42550341
Disturbance in attention 14.93 12.01 5 40879 29861 42550590
Injury 14.69 12.01 51 40833 22265 42558186
Arteriovenous fistula thrombosis 14.66 12.01 7 40877 340 42580111
Refractory anaemia with an excess of blasts 14.56 12.01 7 40877 345 42580106
Ureteric stenosis 14.55 12.01 11 40873 1243 42579208
Chronic hepatitis 14.42 12.01 9 40875 745 42579706
Red blood cells urine positive 14.31 12.01 13 40871 1897 42578554
Bloody peritoneal effluent 14.22 12.01 5 40879 109 42580342
Intercepted product administration error 14.21 12.01 8 40876 547 42579904
Ecchymosis 13.99 12.01 26 40858 7726 42572725
Delirium 13.87 12.01 18 40866 52501 42527950
Porphyria 13.74 12.01 4 40880 46 42580405
Inferior vena cava dilatation 13.72 12.01 9 40875 811 42579640
Peritoneal cloudy effluent 13.71 12.01 7 40877 393 42580058
Urethral meatus stenosis 13.59 12.01 4 40880 48 42580403
Eczema 13.44 12.01 8 40876 34078 42546373
Hyponatraemia 13.39 12.01 51 40833 101411 42479040
Parvovirus B19 infection 13.38 12.01 12 40872 1722 42578729
Neuralgia 13.34 12.01 4 40880 25643 42554808
Pancreatitis acute 13.06 12.01 8 40876 33556 42546895
Blood erythropoietin decreased 13.03 12.01 3 40881 12 42580439
Muscle fibrosis 13.03 12.01 3 40881 12 42580439
Serum ferritin abnormal 12.99 12.01 6 40878 270 42580181
Shunt malfunction 12.89 12.01 6 40878 275 42580176
Bile duct cancer stage IV 12.84 12.01 3 40881 13 42580438
Generalised oedema 12.78 12.01 38 40846 15298 42565153
Blood potassium increased 12.76 12.01 43 40841 18493 42561958
Sepsis 12.76 12.01 265 40619 199069 42381382
Erectile dysfunction 12.75 12.01 4 40880 24909 42555542
Myelofibrosis 12.73 12.01 12 40872 1835 42578616
Arteriovenous fistula occlusion 12.73 12.01 5 40879 150 42580301
Off label use 12.64 12.01 493 40391 637842 41942609
Obstructive airways disorder 12.63 12.01 4 40880 24755 42555696
Mobility decreased 12.59 12.01 67 40817 35239 42545212
Transfusion reaction 12.54 12.01 9 40875 939 42579512
Hyperviscosity syndrome 12.53 12.01 6 40878 293 42580158
Gastrointestinal haemorrhage 12.46 12.01 146 40738 97580 42482871
Arteriovenous fistula site complication 12.44 12.01 7 40877 478 42579973
Dry mouth 12.35 12.01 12 40872 39867 42540584
Nephropathy 12.24 12.01 23 40861 6888 42573563
Portal vein occlusion 12.09 12.01 4 40880 72 42580379

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aplasia pure red cell 1126.54 11.44 359 67032 9219 110512689
Haemoglobin decreased 975.94 11.44 964 66427 247763 110274145
Nephrogenic systemic fibrosis 688.17 11.44 216 67175 5267 110516641
Death 603.96 11.44 1319 66072 697550 109824358
Anaemia 522.27 11.44 1076 66315 546010 109975898
Product storage error 437.34 11.44 229 67162 21499 110500409
Anti-erythropoietin antibody positive 404.50 11.44 93 67298 636 110521272
Peritonitis bacterial 326.14 11.44 149 67242 10384 110511524
Haemoglobin abnormal 308.93 11.44 137 67254 8901 110513007
Skin induration 279.32 11.44 104 67287 4291 110517617
Anti-erythropoietin antibody negative 266.68 11.44 57 67334 264 110521644
Shunt stenosis 265.25 11.44 76 67315 1340 110520568
Skin hypertrophy 220.38 11.44 91 67300 4956 110516952
Skin tightness 201.26 11.44 88 67303 5525 110516383
Plasma cell myeloma 197.67 11.44 217 67174 62719 110459189
Peritoneal dialysis complication 186.87 11.44 67 67324 2479 110519429
Thrombocytopenia 171.17 11.44 534 66857 348351 110173557
Myelodysplastic syndrome 160.95 11.44 153 67238 37331 110484577
Cardio-respiratory arrest 160.42 11.44 268 67123 115568 110406340
Therapeutic response decreased 156.59 11.44 240 67151 96259 110425649
Chronic kidney disease 156.37 11.44 212 67179 76079 110445829
Pancytopenia 150.62 11.44 369 67022 209244 110312664
Platelet count decreased 148.24 11.44 389 67002 230054 110291854
Skin fibrosis 146.31 11.44 48 67343 1352 110520556
Peritonitis 145.56 11.44 136 67255 32471 110489437
Haematocrit decreased 138.96 11.44 186 67205 65931 110455977
Synovitis 134.91 11.44 8 67383 274084 110247824
Completed suicide 133.17 11.44 3 67388 242378 110279530
Drug intolerance 129.74 11.44 43 67348 406469 110115439
Renal failure 125.37 11.44 362 67029 226212 110295696
Acute myocardial infarction 121.59 11.44 198 67193 83579 110438329
Shunt occlusion 121.08 11.44 44 67347 1693 110520215
Hand deformity 115.26 11.44 4 67387 218502 110303406
Sepsis 114.41 11.44 448 66943 326898 110195010
Reticulocyte count decreased 112.68 11.44 36 67355 930 110520978
Joint contracture 109.05 11.44 45 67346 2446 110519462
Rheumatoid arthritis 108.06 11.44 25 67366 299588 110222320
Glossodynia 107.68 11.44 7 67384 221997 110299911
Joint swelling 107.06 11.44 69 67322 442776 110079132
Hepatic enzyme increased 105.82 11.44 32 67359 320860 110201048
Contraindicated product administered 104.11 11.44 14 67377 248253 110273655
Dialysis 103.68 11.44 90 67301 19529 110502379
Refractory cytopenia with unilineage dysplasia 102.94 11.44 33 67358 862 110521046
Arthropathy 99.77 11.44 26 67365 287496 110234412
Diabetic foot 99.40 11.44 49 67342 4046 110517862
Asthenia 98.86 11.44 738 66653 688261 109833647
Neutropenia 96.68 11.44 468 66923 374152 110147756
Fibrosis 95.49 11.44 59 67332 7583 110514325
Systemic lupus erythematosus 94.17 11.44 20 67371 254318 110267590
Helicobacter infection 93.63 11.44 4 67387 181873 110340035
Toxicity to various agents 93.46 11.44 93 67298 480462 110041446
Infusion related reaction 92.64 11.44 59 67332 381103 110140805
Duodenal ulcer perforation 91.17 11.44 4 67387 177696 110344212
Drug abuse 91.00 11.44 4 67387 177407 110344501
Hyperparathyroidism 90.73 11.44 45 67346 3765 110518143
Renal transplant 88.42 11.44 42 67349 3196 110518712
Fibromyalgia 87.19 11.44 4 67387 170905 110351003
Cardiac failure 87.13 11.44 282 67109 187344 110334564
Iron overload 84.58 11.44 36 67355 2115 110519793
Hypervolaemia 84.44 11.44 126 67265 49334 110472574
Treatment failure 83.84 11.44 32 67359 277202 110244706
Device interaction 83.00 11.44 27 67364 740 110521168
Cerebrovascular accident 81.95 11.44 270 67121 181014 110340894
Pericarditis 81.59 11.44 17 67374 219097 110302811
Intentional product use issue 81.22 11.44 25 67366 247881 110274027
Calciphylaxis 81.02 11.44 43 67348 4144 110517764
Asthma 80.64 11.44 26 67365 250265 110271643
Irritable bowel syndrome 80.15 11.44 5 67386 164210 110357698
Folliculitis 79.22 11.44 6 67385 167647 110354261
Arteriovenous fistula site complication 78.98 11.44 28 67363 1002 110520906
IVth nerve paralysis 78.69 11.44 25 67366 634 110521274
Oedema peripheral 77.97 11.44 401 66990 328259 110193649
Bone marrow failure 77.60 11.44 132 67259 57716 110464192
Blood urea increased 77.18 11.44 128 67263 54829 110467079
Serum ferritin increased 76.42 11.44 61 67330 11786 110510122
Headache 75.50 11.44 280 67111 882097 109639811
Neutralising antibodies positive 73.46 11.44 21 67370 367 110521541
Sinusitis 73.35 11.44 45 67346 296643 110225265
Red blood cell count decreased 72.55 11.44 138 67253 65785 110456123
Cardiac failure congestive 71.95 11.44 229 67162 150771 110371137
Haematocrit abnormal 71.46 11.44 30 67361 1703 110520205
Alopecia 70.42 11.44 71 67320 364682 110157226
Transfusion 70.04 11.44 82 67309 25390 110496518
Nasopharyngitis 68.20 11.44 84 67307 394277 110127631
Haemodialysis 67.95 11.44 68 67323 17651 110504257
Blood creatinine increased 67.67 11.44 255 67136 182634 110339274
Hospitalisation 66.89 11.44 215 67176 142278 110379630
Liver injury 66.71 11.44 7 67384 150406 110371502
Bursitis 66.39 11.44 3 67388 129915 110391993
Sleep disorder 65.12 11.44 20 67371 198624 110323284
Athetosis 64.01 11.44 16 67375 162 110521746
Drug hypersensitivity 63.61 11.44 112 67279 453978 110067930
Blood cholesterol increased 63.53 11.44 17 67374 184768 110337140
Drug ineffective 63.18 11.44 608 66783 1519932 109001976
Condition aggravated 60.97 11.44 236 67155 734600 109787308
Abdominal discomfort 60.92 11.44 91 67300 393767 110128141
Deep vein thrombosis 60.24 11.44 205 67186 139682 110382226
Blood product transfusion dependent 60.02 11.44 19 67372 476 110521432
Product use issue 59.78 11.44 61 67330 311634 110210274
IgA nephropathy 59.74 11.44 32 67359 3141 110518767
Scar 59.68 11.44 62 67329 16819 110505089
Ill-defined disorder 58.73 11.44 12 67379 156841 110365067
Skin hyperpigmentation 58.72 11.44 46 67345 8650 110513258
Arthralgia 58.70 11.44 260 67131 779372 109742536
Wheezing 58.64 11.44 42 67349 255188 110266720
Therapeutic product effect incomplete 58.07 11.44 32 67359 223773 110298135
Wound 57.33 11.44 36 67355 234401 110287507
C-reactive protein abnormal 55.10 11.44 7 67384 129688 110392220
Product use in unapproved indication 53.51 11.44 121 67270 447256 110074652
Splenomegaly 53.12 11.44 70 67321 24428 110497480
Hyperparathyroidism secondary 53.06 11.44 30 67361 3274 110518634
Weight increased 52.24 11.44 111 67280 419533 110102375
Marrow hyperplasia 51.21 11.44 24 67367 1772 110520136
Type 2 diabetes mellitus 51.05 11.44 22 67369 177210 110344698
Ultrafiltration failure 50.80 11.44 16 67375 394 110521514
Peritoneal cloudy effluent 49.79 11.44 18 67373 682 110521226
Septic shock 49.70 11.44 209 67182 157319 110364589
White blood cell count decreased 48.98 11.44 272 67119 229118 110292790
Lip dry 48.98 11.44 3 67388 100080 110421828
Urticaria 48.98 11.44 74 67317 318783 110203125
Pneumonia 48.74 11.44 777 66614 875937 109645971
Peau d'orange 47.39 11.44 14 67377 276 110521632
Lower respiratory tract infection 47.26 11.44 47 67344 243059 110278849
Migraine 46.81 11.44 23 67368 171629 110350279
Swelling 46.11 11.44 90 67301 350951 110170957
Blood potassium increased 46.09 11.44 77 67314 33172 110488736
Drug specific antibody absent 45.22 11.44 13 67378 232 110521676
Hypotension 45.19 11.44 503 66888 523346 109998562
Fungal peritonitis 45.00 11.44 20 67371 1305 110520603
Dry mouth 44.51 11.44 34 67357 199914 110321994
Drug-induced liver injury 43.30 11.44 10 67381 120057 110401851
Extremity contracture 42.53 11.44 21 67370 1740 110520168
Kidney transplant rejection 42.33 11.44 44 67347 11943 110509965
Impaired healing 41.84 11.44 35 67356 196682 110325226
Anhedonia 41.31 11.44 49 67342 15379 110506529
Therapeutic product effect decreased 41.21 11.44 53 67338 244263 110277645
Blood iron increased 40.92 11.44 22 67369 2176 110519732
Premature delivery 39.89 11.44 69 67322 30563 110491345
Metabolic encephalopathy 39.78 11.44 41 67350 11019 110510889
Haemolytic anaemia 39.64 11.44 56 67335 20864 110501044
Nephrogenic anaemia 39.38 11.44 28 67363 4549 110517359
Psoriasis 39.34 11.44 18 67373 139975 110381933
Sciatica 39.22 11.44 5 67386 92394 110429514
Discomfort 38.94 11.44 44 67347 214663 110307245
Malnutrition 38.92 11.44 64 67327 27215 110494693
Blood parathyroid hormone increased 38.90 11.44 27 67364 4221 110517687
Hypocalcaemia 38.60 11.44 107 67284 65259 110456649
Pleural effusion 38.11 11.44 211 67180 177498 110344410
Blood albumin decreased 36.95 11.44 63 67328 27589 110494319
Renal impairment 36.65 11.44 218 67173 188227 110333681
Febrile bone marrow aplasia 36.47 11.44 49 67342 17416 110504492
Cellulitis enterococcal 36.13 11.44 8 67383 45 110521863
Hyperkalaemia 35.20 11.44 170 67221 135626 110386282
Non-neutralising antibodies positive 34.15 11.44 8 67383 60 110521848
Peripheral swelling 33.93 11.44 129 67262 403905 110118003
Expired product administered 33.89 11.44 33 67358 8287 110513621
Noninfectious peritonitis 33.86 11.44 11 67380 300 110521608
Full blood count decreased 33.84 11.44 66 67325 32033 110489875
Gastrointestinal haemorrhage 33.82 11.44 194 67197 165324 110356584
Blister 33.73 11.44 54 67337 227322 110294586
Stomatitis 33.18 11.44 72 67319 270170 110251738
Haemoglobin increased 33.06 11.44 34 67357 9113 110512795
Transferrin saturation increased 32.86 11.44 10 67381 219 110521689
Obesity 32.75 11.44 14 67377 113337 110408571
Porphyria 32.23 11.44 10 67381 234 110521674
Arteriovenous fistula operation 32.17 11.44 11 67380 353 110521555
Night sweats 32.16 11.44 21 67370 133962 110387946
Dehydration 32.13 11.44 285 67106 279226 110242682
Blood erythropoietin abnormal 32.02 11.44 5 67386 0 110521908
Endometrial disorder 31.99 11.44 13 67378 679 110521229
Arthritis 31.88 11.44 33 67358 167553 110354355
Pain 31.47 11.44 402 66989 954553 109567355
Red blood cell sedimentation rate increased 31.45 11.44 5 67386 78297 110443611
Haemolysis 31.33 11.44 43 67348 15596 110506312
Generalised oedema 31.00 11.44 62 67329 30642 110491266
Memory impairment 30.91 11.44 45 67346 196899 110325009
Musculoskeletal stiffness 30.80 11.44 79 67312 279743 110242165
Skin discolouration 30.67 11.44 82 67309 48964 110472944
Cytopenia 30.63 11.44 61 67330 30055 110491853
Hepatitis C 30.52 11.44 38 67353 12535 110509373
Maternal exposure during pregnancy 30.39 11.44 69 67322 254814 110267094
Intentional product misuse 30.34 11.44 22 67369 132882 110389026
Grip strength decreased 30.29 11.44 6 67385 80168 110441740
Osteoarthritis 29.38 11.44 41 67350 182582 110339326
Complications of transplanted kidney 29.35 11.44 29 67362 7413 110514495
Renal disorder 29.22 11.44 81 67310 49398 110472510
Loss of personal independence in daily activities 29.15 11.44 29 67362 149991 110371917
Insomnia 29.08 11.44 117 67274 360473 110161435
Incision site pain 28.88 11.44 20 67371 3115 110518793
Knee arthroplasty 28.85 11.44 3 67388 64945 110456963
Cerebellar stroke 28.81 11.44 13 67378 879 110521029
Reticulocyte count abnormal 28.76 11.44 8 67383 126 110521782
Peritoneal dialysis 28.65 11.44 13 67378 891 110521017
Azotaemia 28.62 11.44 33 67358 10052 110511856
Prescribed overdose 28.37 11.44 9 67382 87572 110434336
Hypercholesterolaemia 28.26 11.44 10 67381 90827 110431081
Drug interaction 28.04 11.44 184 67207 499999 110021909
Epilepsy 27.97 11.44 13 67378 100196 110421712
Delirium 27.52 11.44 25 67366 135000 110386908
Disease complication 27.35 11.44 25 67366 5802 110516106
Liver function test increased 27.12 11.44 10 67381 88538 110433370
Parvovirus B19 test positive 27.07 11.44 8 67383 158 110521750
Road traffic accident 26.93 11.44 16 67375 107382 110414526
Neuropathy peripheral 26.70 11.44 194 67197 179083 110342825
Bloody peritoneal effluent 26.52 11.44 8 67383 170 110521738
Atrial fibrillation 26.31 11.44 234 67157 229408 110292500
Unresponsive to stimuli 26.15 11.44 92 67299 63698 110458210
Soft tissue infection 26.12 11.44 23 67368 5084 110516824
Emotional distress 26.07 11.44 73 67318 44774 110477134
Iron deficiency 25.89 11.44 43 67348 18433 110503475
Peripheral arterial occlusive disease 25.72 11.44 30 67361 9250 110512658
Frequent bowel movements 25.63 11.44 6 67385 71384 110450524
Iron binding capacity total abnormal 25.62 11.44 4 67387 0 110521908
Reticulocytopenia 25.33 11.44 9 67382 324 110521584
Peripheral venous disease 24.93 11.44 10 67381 84107 110437801
Nail disorder 24.92 11.44 3 67388 57932 110463976
Acquired haemophilia 24.75 11.44 17 67374 2614 110519294
Disease progression 24.61 11.44 242 67149 243792 110278116
Autoimmune disorder 24.53 11.44 5 67386 65478 110456430
Shunt malfunction 24.41 11.44 9 67382 361 110521547
Hypertensive crisis 24.35 11.44 49 67342 24323 110497585
Injection site reaction 24.18 11.44 12 67379 89058 110432850
Iron binding capacity total decreased 24.00 11.44 10 67381 557 110521351
Neoplasm skin 23.94 11.44 18 67373 3186 110518722
Staphylococcal bacteraemia 23.60 11.44 39 67352 16649 110505259
Overdose 23.48 11.44 69 67322 233725 110288183
Morganella infection 23.45 11.44 13 67378 1366 110520542
Adverse drug reaction 23.42 11.44 18 67373 105541 110416367
Parvovirus B19 infection 23.35 11.44 17 67374 2864 110519044
Dyspepsia 23.33 11.44 51 67340 190914 110330994
Vulvovaginal mycotic infection 23.17 11.44 22 67369 5355 110516553
Urinary tract infection 23.14 11.44 302 67089 325980 110195928
Acute pulmonary oedema 23.07 11.44 39 67352 16957 110504951
Sedation 22.85 11.44 7 67384 69676 110452232
Shunt infection 22.81 11.44 8 67383 277 110521631
Blood erythropoietin decreased 22.60 11.44 5 67386 28 110521880
End stage renal disease 22.45 11.44 44 67347 21429 110500479
Serum ferritin abnormal 22.33 11.44 9 67382 460 110521448
Haemorrhoidal haemorrhage 22.16 11.44 26 67365 8067 110513841
Myocardial infarction 22.14 11.44 196 67195 191887 110330021
Deformity 21.98 11.44 29 67362 10131 110511777
Sudden death 21.97 11.44 47 67344 24348 110497560
Osteonecrosis 21.69 11.44 57 67334 33684 110488224
Leukopenia 21.58 11.44 160 67231 148631 110373277
Hip arthroplasty 21.46 11.44 4 67387 55809 110466099
Respiratory failure 21.45 11.44 213 67178 215119 110306789
Anaemia of chronic disease 21.43 11.44 17 67374 3255 110518653
Unevaluable event 21.40 11.44 82 67309 59145 110462763
Serotonin syndrome 21.18 11.44 5 67386 59148 110462760
Craniocervical syndrome 21.03 11.44 6 67385 104 110521804
Bone pain 20.98 11.44 87 67304 65046 110456862
Injection site erythema 20.97 11.44 16 67375 94160 110427748
Amnesia 20.91 11.44 20 67371 105388 110416520
Device related infection 20.72 11.44 62 67329 39457 110482451
Refusal of treatment by patient 20.38 11.44 27 67364 9467 110512441
Cardiac arrest 20.27 11.44 196 67195 196557 110325351
Mental status changes 20.23 11.44 96 67295 76026 110445882
Hip fracture 20.22 11.44 57 67334 35094 110486814
Refractory anaemia with an excess of blasts 20.16 11.44 10 67381 837 110521071
Arteriovenous fistula thrombosis 20.15 11.44 9 67382 594 110521314
Inadequate osteointegration 20.08 11.44 4 67387 12 110521896
Arteriovenous graft site haemorrhage 20.08 11.44 4 67387 12 110521896
C-reactive protein increased 19.99 11.44 67 67324 217852 110304056
Erythropoiesis abnormal 19.57 11.44 9 67382 636 110521272
Renal ischaemia 19.50 11.44 14 67377 2309 110519599
Chorea 19.48 11.44 16 67375 3219 110518689
Haemochromatosis 19.40 11.44 12 67379 1545 110520363
Iron binding capacity unsaturated decreased 19.21 11.44 3 67388 0 110521908
Transferrin abnormal 19.21 11.44 3 67388 0 110521908
Haemorrhage 19.20 11.44 121 67270 106571 110415337
Ischaemic stroke 19.11 11.44 62 67329 41201 110480707
Back injury 19.10 11.44 3 67388 47396 110474512
Pseudomonal bacteraemia 19.06 11.44 18 67373 4353 110517555
Anti-erythropoietin antibody 18.99 11.44 4 67387 17 110521891
Folate deficiency 18.83 11.44 18 67373 4420 110517488
Escherichia sepsis 18.73 11.44 27 67364 10245 110511663
Transfusion reaction 18.50 11.44 13 67378 2072 110519836
Biopsy bone marrow abnormal 18.42 11.44 8 67383 494 110521414
Illness 18.24 11.44 14 67377 82157 110439751
Failure to thrive 18.23 11.44 31 67360 13543 110508365
Peritoneal fluid analysis abnormal 18.20 11.44 5 67386 75 110521833
Inflammation 18.01 11.44 59 67332 193179 110328729
Nasal congestion 17.97 11.44 20 67371 98262 110423646
Heparin-induced thrombocytopenia 17.94 11.44 28 67363 11396 110510512
Tooth extraction 17.89 11.44 30 67361 12961 110508947
Graft infection 17.86 11.44 9 67382 779 110521129
Bone marrow reticulin fibrosis 17.73 11.44 7 67384 339 110521569
Cerebrovascular disorder 17.57 11.44 16 67375 3695 110518213
Foot deformity 17.55 11.44 4 67387 48476 110473432
White blood cell count increased 17.53 11.44 110 67281 96732 110425176
Cardiomegaly 17.51 11.44 48 67343 29082 110492826
Ecchymosis 17.49 11.44 35 67356 17303 110504605
Diarrhoea 17.48 11.44 855 66536 1138650 109383258
Oropharyngeal pain 17.47 11.44 35 67356 135241 110386667
Wound infection 17.23 11.44 20 67371 96445 110425463
Erythroid series abnormal 17.13 11.44 3 67388 3 110521905
Epistaxis 17.12 11.44 137 67254 130235 110391673
Intensive care unit acquired weakness 17.07 11.44 13 67378 2346 110519562
Staphylococcal infection 17.01 11.44 86 67305 69858 110452050
Mean cell volume increased 16.83 11.44 23 67368 8307 110513601
Coeliac disease 16.81 11.44 3 67388 43184 110478724
Hypertensive encephalopathy 16.80 11.44 10 67381 1201 110520707
Lung disorder 16.76 11.44 55 67336 179992 110341916
Stress 16.60 11.44 24 67367 105324 110416584
Acute myeloid leukaemia 16.52 11.44 56 67335 38054 110483854
Eczema 16.46 11.44 12 67379 72281 110449627
Laryngitis 16.39 11.44 3 67388 42408 110479500
Bone debridement 16.39 11.44 7 67384 415 110521493
Obstructive airways disorder 16.33 11.44 4 67387 46145 110475763
Pulmonary fibrosis 16.32 11.44 23 67368 102019 110419889
Musculoskeletal pain 16.29 11.44 57 67334 182966 110338942
Red blood cell count abnormal 16.28 11.44 11 67380 1647 110520261
Decubitus ulcer 16.27 11.44 35 67356 18201 110503707
Exostosis 16.23 11.44 4 67387 45952 110475956
Staphylococcal sepsis 16.15 11.44 34 67357 17420 110504488
Inferior vena cava dilatation 16.13 11.44 9 67382 958 110520950
Thrombosis in device 16.08 11.44 18 67373 5309 110516599
Klebsiella sepsis 16.04 11.44 16 67375 4137 110517771
Vascular parkinsonism 16.04 11.44 5 67386 119 110521789
Blood erythropoietin increased 15.96 11.44 4 67387 41 110521867
Conjunctival discolouration 15.84 11.44 5 67386 124 110521784
Skin plaque 15.84 11.44 28 67363 12617 110509291
Inappropriate schedule of product administration 15.82 11.44 67 67324 203570 110318338
Bone marrow disorder 15.81 11.44 16 67375 4207 110517701
Cognitive disorder 15.79 11.44 18 67373 87493 110434415
Urethral meatus stenosis 15.79 11.44 4 67387 43 110521865
Asterixis 15.71 11.44 14 67377 3144 110518764
Bronchial haemorrhage 15.55 11.44 10 67381 1377 110520531
Toxoplasmosis 15.40 11.44 14 67377 3225 110518683
Skin mass 15.33 11.44 24 67367 9792 110512116
Protein urine present 15.13 11.44 26 67365 11458 110510450
Haemorrhoids 15.10 11.44 52 67339 35620 110486288
Complication associated with device 15.10 11.44 36 67355 20037 110501871
Muscle contracture 15.07 11.44 13 67378 2795 110519113
Inadequate peritoneal dialysis 15.06 11.44 3 67388 9 110521899
Dizziness 14.97 11.44 318 67073 697875 109824033
Throat irritation 14.86 11.44 7 67384 53545 110468363
Ear infection 14.82 11.44 10 67381 62722 110459186
Blood iron abnormal 14.82 11.44 10 67381 1494 110520414
Febrile neutropenia 14.71 11.44 273 67118 316494 110205414
Enterococcus test positive 14.70 11.44 13 67378 2891 110519017
Vascular calcification 14.68 11.44 9 67382 1141 110520767
Arteriovenous fistula occlusion 14.62 11.44 7 67384 542 110521366
Petechiae 14.59 11.44 39 67352 23278 110498630
Critical illness 14.57 11.44 7 67384 546 110521362
Nephropathy 14.57 11.44 28 67363 13439 110508469
Premature rupture of membranes 14.57 11.44 16 67375 4621 110517287
Disturbance in attention 14.49 11.44 10 67381 61985 110459923
Injection site swelling 14.40 11.44 10 67381 61780 110460128
Micturition disorder 14.40 11.44 16 67375 4682 110517226
Onychomycosis 14.31 11.44 3 67388 38528 110483380
Akathisia 14.31 11.44 32 67359 17081 110504827
Penile squamous cell carcinoma 14.15 11.44 4 67387 67 110521841
Myelofibrosis 14.14 11.44 13 67378 3038 110518870
Gastrointestinal disorder 14.05 11.44 88 67303 241864 110280044
Delayed graft function 13.92 11.44 15 67376 4242 110517666
Osteolysis 13.90 11.44 17 67374 5506 110516402
Myocardial oedema 13.78 11.44 7 67384 616 110521292
Myelopathy 13.77 11.44 17 67374 5559 110516349
Procedural complication 13.76 11.44 21 67370 8384 110513524
Transient ischaemic attack 13.73 11.44 76 67315 63906 110458002
Arteriovenous fistula site haemorrhage 13.68 11.44 6 67385 379 110521529
Pregnancy 13.68 11.44 7 67384 51060 110470848
Arteriovenous fistula site infection 13.67 11.44 5 67386 196 110521712
Chronic kidney disease-mineral and bone disorder 13.62 11.44 7 67384 631 110521277
Liver disorder 13.55 11.44 43 67348 142200 110379708
Gastrooesophageal reflux disease 13.50 11.44 60 67331 179916 110341992
Extremity necrosis 13.50 11.44 14 67377 3788 110518120
Osteomyelitis 13.49 11.44 51 67340 36549 110485359
Supraventricular tachycardia 13.46 11.44 39 67352 24383 110497525
Streptococcal sepsis 13.40 11.44 16 67375 5056 110516852
Transferrin saturation decreased 13.40 11.44 9 67382 1334 110520574
Abdominal pain upper 13.38 11.44 142 67249 348969 110172939
Escherichia bacteraemia 13.37 11.44 23 67368 10141 110511767
Rash 13.25 11.44 390 67001 820574 109701334
Red blood cells urine positive 13.12 11.44 16 67375 5169 110516739
Bile duct cancer stage IV 13.11 11.44 3 67388 20 110521888
Lower limb fracture 13.06 11.44 16 67375 75332 110446576
Dry eye 13.04 11.44 9 67382 55784 110466124
Uterine dilation and evacuation 12.99 11.44 3 67388 21 110521887
Erythema infectiosum 12.89 11.44 5 67386 231 110521677
Live birth 12.85 11.44 14 67377 69470 110452438
Blood stem cell transplant failure 12.85 11.44 7 67384 711 110521197
Product quality issue 12.79 11.44 17 67374 77282 110444626
High turnover osteopathy 12.76 11.44 4 67387 97 110521811
Blood culture positive 12.72 11.44 21 67370 8955 110512953
Right ventricular dilatation 12.71 11.44 11 67380 2376 110519532
Malaise 12.70 11.44 312 67079 671507 109850401
Depressed mood 12.70 11.44 11 67380 60798 110461110
Surgical procedure repeated 12.60 11.44 7 67384 738 110521170
Lymphocytosis 12.57 11.44 16 67375 5395 110516513
Hypercalcaemia 12.51 11.44 59 67332 46598 110475310
Hypersplenism 12.42 11.44 7 67384 759 110521149
Injection site pruritus 12.34 11.44 8 67383 51250 110470658
Full blood count abnormal 12.31 11.44 67 67324 55985 110465923
Angioedema 12.28 11.44 26 67365 98474 110423434
Pulmonary oedema 12.26 11.44 104 67287 100555 110421353
Vasculitic ulcer 12.22 11.44 5 67386 266 110521642
Product administration error 12.21 11.44 50 67341 37167 110484741
Uterine atony 12.20 11.44 5 67386 267 110521641
Peripheral ischaemia 11.98 11.44 23 67368 11035 110510873
Hyperuricaemia 11.96 11.44 27 67364 14504 110507404
Reticulocyte count increased 11.95 11.44 9 67382 1597 110520311
Neck pain 11.88 11.44 37 67354 123093 110398815
Parathyroidectomy 11.84 11.44 5 67386 288 110521620
Amyloidosis 11.82 11.44 12 67379 3169 110518739
Sickle cell anaemia with crisis 11.78 11.44 21 67370 9524 110512384
Bladder transitional cell carcinoma stage 0 11.74 11.44 4 67387 127 110521781
Renal lymphocele 11.65 11.44 4 67387 130 110521778
Purpura 11.61 11.44 37 67354 24351 110497557
Intercepted product administration error 11.58 11.44 7 67384 865 110521043
Urosepsis 11.52 11.44 43 67348 30632 110491276
Clostridium difficile colitis 11.48 11.44 55 67336 43723 110478185
Red blood cell abnormality 11.46 11.44 7 67384 881 110521027
Skin exfoliation 11.45 11.44 92 67299 87559 110434349

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03XA01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
OTHER ANTIANEMIC PREPARATIONS
Other antianemic preparations
FDA CS M0007726 Erythropoietin
FDA PE N0000009319 Increased Erythroid Cell Production
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175665 Erythropoiesis-stimulating Agent
CHEBI has role CHEBI:24621 hormone
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B03XA Other antianemic preparations 8 drugs
daprodustatdarbepoetin alfaluspaterceptmethoxy polyethylene glycol-epoetin betamolidustatpeginesatideroxadustatvadadustat

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia due to chemotherapy indication 429564000
Anemia in chronic kidney disease indication 707323002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Erythropoietin receptor Membrane receptor AGONIST IC50 11.15 IUPHAR DRUG LABEL

External reference:

IDSource
D03231 KEGG_DRUG
4019505 VUID
N0000147625 NUI
4019505 VANDF
4037607 VANDF
CHEBI:749425 CHEBI
CHEMBL1201565 ChEMBL_ID
DB00016 DRUGBANK_ID
105694 RXNORM
34327 MMSL
3530 MMSL
4668 MMSL
866 MMSL
d00223 MMSL
003439 NDDF
017553 NDDF
108964008 SNOMEDCT_US
386947003 SNOMEDCT_US
83042003 SNOMEDCT_US
C0357126 UMLSCUI
D000068817 MESH_DESCRIPTOR_UI
92043599 PUBCHEM_CID
11096-26-7 SECONDARY_CAS_RN
4921 IUPHAR_LIGAND_ID
D004921 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None