epoetin alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
erythropoietin type blood factors	4995	113427-24-0

Description:

Molecule	Description
Synonyms: epoetin alfa-epbx epoetin alfa epogen procrit epoetin alfa (genetical recombination) erythropoietin	Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

epoetin alfa-epbx
epoetin alfa
epogen
procrit
epoetin alfa (genetical recombination)
erythropoietin

Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
1	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 1, 1989	FDA	AMGEN

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplasia pure red cell	726.37	11.79	218	40970	4269	63443565
Haemoglobin decreased	633.48	11.79	614	40574	144871	63302963
Death	523.06	11.79	897	40291	373484	63074350
Nephrogenic systemic fibrosis	481.89	11.79	160	41028	4396	63443438
Product storage error	344.10	11.79	176	41012	14780	63433054
Anaemia	341.18	11.79	650	40538	292780	63155054
Therapeutic response decreased	271.50	11.79	262	40926	61263	63386571
Anti-erythropoietin antibody positive	222.13	11.79	52	41136	362	63447472
Peritonitis bacterial	191.37	11.79	83	41105	4796	63443038
Haemoglobin abnormal	181.60	11.79	81	41107	5007	63442827

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplasia pure red cell	749.45	12.12	272	37013	5860	34913786
Haemoglobin decreased	475.26	12.12	613	36672	120159	34799487
Therapeutic response decreased	451.99	12.12	318	36967	28995	34890651
Nephrogenic systemic fibrosis	353.07	12.12	140	37145	3865	34915781
Anti-erythropoietin antibody positive	279.75	12.12	81	37204	814	34918832
Product storage error	225.56	12.12	128	37157	7994	34911652
Anaemia	220.24	12.12	645	36640	232690	34686956
Death	181.44	12.12	870	36415	397179	34522467
Skin induration	161.43	12.12	67	37218	2084	34917562
Haemoglobin abnormal	152.32	12.12	77	37208	3803	34915843

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplasia pure red cell	1003.92	10.82	330	60065	7480	79676513
Haemoglobin decreased	760.21	10.82	887	59508	221232	79462761
Nephrogenic systemic fibrosis	617.42	10.82	216	60179	5944	79678049
Death	486.05	10.82	1217	59178	565297	79118696
Product storage error	436.02	10.82	223	60172	16003	79667990
Anaemia	392.58	10.82	967	59428	444048	79239945
Anti-erythropoietin antibody positive	370.55	10.82	90	60305	627	79683366
Haemoglobin abnormal	306.48	10.82	135	60260	6919	79677074
Peritonitis bacterial	293.88	10.82	144	60251	9423	79674570
Skin induration	254.43	10.82	104	60291	4421	79679572

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B03XA01	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS OTHER ANTIANEMIC PREPARATIONS Other antianemic preparations
FDA CS	M0007726	Erythropoietin
FDA EPC	N0000175665	Erythropoiesis-stimulating Agent
FDA PE	N0000009319	Increased Erythroid Cell Production
MeSH PA	D006397	Hematinics
MeSH PA	D006401	Hematologic Agents