lipegfilgrastim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
granulocyte colony stimulating factor (G-CSF) type substances 4991 1117844-87-7

Description:

MoleculeDescription

Synonyms:

  • lipegfilgrastim
  • lonquex
  • XM22
A long acting glyco-pegylated recombinant form of human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Similar to G-CSF, lipegfilgrastim binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, lipegfilgrastim has a prolonged plasma half-life.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.30 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 25, 2013 EMA Sicor Biotech UAB

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Thrombocytopenia 93.62 46.55 50 1235 151107 63336630
Febrile neutropenia 90.07 46.55 45 1240 118404 63369333
Post-traumatic pain 60.51 46.55 10 1275 420 63487317
Neutropenia 58.59 46.55 39 1246 174966 63312771
Leukopenia 48.88 46.55 26 1259 77264 63410473

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 101.80 55.41 21 1624 1279 34954007
SARS-CoV-2 test negative 94.80 55.41 19 1626 1001 34954285
Accident 91.84 55.41 25 1620 5022 34950264
Proctalgia 79.72 55.41 23 1622 5700 34949586
General physical health deterioration 75.55 55.41 56 1589 128213 34827073
Febrile neutropenia 72.32 55.41 56 1589 136793 34818493
Haemorrhoids 69.40 55.41 26 1619 14549 34940737
Testicular germ cell cancer metastatic 62.77 55.41 9 1636 57 34955229
Neutropenia 61.54 55.41 54 1591 156724 34798562

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 132.45 45.06 91 2913 230908 79510476
Thrombocytopenia 130.16 45.06 95 2909 265164 79476220
Neutropenia 125.46 45.06 96 2908 287614 79453770
General physical health deterioration 107.27 45.06 86 2918 275152 79466232
Anal inflammation 98.46 45.06 20 2984 1410 79739974
SARS-CoV-2 test negative 87.47 45.06 18 2986 1353 79740031
Accident 79.11 45.06 24 2980 8807 79732577
Leukopenia 78.84 45.06 51 2953 116462 79624922
Proctalgia 67.93 45.06 22 2982 9979 79731405
Testicular germ cell cancer metastatic 64.90 45.06 9 2995 56 79741328
Haemorrhoids 54.34 45.06 25 2979 29103 79712281
Seminoma 54.31 45.06 9 2995 202 79741182
Post-traumatic pain 53.59 45.06 10 2994 451 79740933

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AA14 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Colony stimulating factors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chemotherapy-induced neutropenia indication 425229001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Granulocyte colony-stimulating factor receptor Membrane receptor ACTIVATOR DRUG LABEL DRUG LABEL

External reference:

IDSource
4AWF0N6QV3 UNII
D10242 KEGG_DRUG
C3640212 UMLSCUI
CHEMBL4594230 ChEMBL_ID
77910626 PUBCHEM_CID
DB13200 DRUGBANK_ID
9342 INN_ID
C455861 MESH_SUPPLEMENTAL_RECORD_UI
1440046 RXNORM
015533 NDDF
1268483008 SNOMEDCT_US
710282003 SNOMEDCT_US

Pharmaceutical products:

None