filgrastim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
granulocyte colony stimulating factor (G-CSF) type substances 4987 121181-53-1

Description:

MoleculeDescription

Synonyms:

  • nivestim
  • filgrastim
  • neupogen
  • r-metHuG-CSF
  • filgrastim-sndz
  • zarxio
A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of NEUTROPENIA, preparation and collection of blood progenitor cells, and for use in PERIPHERAL BLOOD STEM CELL TRANSPLANTATION.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.35 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 23, 2021 PMDA KYOWA KIRIN Co., Ltd.
Sept. 15, 2008 EMA
Feb. 20, 1991 FDA AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3071.96 13.58 1676 59203 156673 90410895
Neutropenia 1588.81 13.58 1267 59612 223637 90343931
Thrombocytopenia 772.29 13.58 820 60059 207905 90359663
Bone pain 612.17 13.58 428 60451 61555 90506013
Pancytopenia 579.88 13.58 546 60333 119717 90447851
Pyrexia 556.04 13.58 1308 59571 659177 89908391
White blood cell count decreased 450.70 13.58 558 60321 166551 90401017
Neutrophil count decreased 407.79 13.58 357 60522 71175 90496393
Mucosal inflammation 388.94 13.58 317 60562 57308 90510260
Anaemia 377.87 13.58 771 60108 352031 90215537
Neutropenic sepsis 341.69 13.58 189 60690 17941 90549627
Platelet count decreased 335.30 13.58 436 60443 136533 90431035
Cytokine release syndrome 313.56 13.58 209 60670 27764 90539804
Sepsis 283.58 13.58 465 60414 179349 90388219
Staphylococcal bacteraemia 244.05 13.58 113 60766 7356 90560212
Death 242.68 13.58 765 60114 455786 90111782
Disease progression 233.47 13.58 395 60484 156220 90411348
Leukopenia 220.92 13.58 304 60575 100406 90467162
Pemphigus 204.08 13.58 3 60876 326861 90240707
Off label use 199.52 13.58 1342 59537 1100910 89466658
Synovitis 197.94 13.58 5 60874 329747 90237821
Joint swelling 191.30 13.58 51 60828 503249 90064319
Rheumatoid arthritis 190.03 13.58 14 60865 362600 90204968
Glossodynia 189.01 13.58 6 60873 321773 90245795
Septic shock 181.49 13.58 252 60627 83908 90483660
Systemic lupus erythematosus 181.30 13.58 17 60862 361879 90205689
Acute myeloid leukaemia 172.70 13.58 129 60750 20511 90547057
Arthropathy 171.32 13.58 22 60857 366220 90201348
Computerised tomogram thorax abnormal 170.59 13.58 61 60818 2026 90565542
Drug intolerance 166.97 13.58 47 60832 447544 90120024
Contraindicated product administered 163.14 13.58 14 60865 320125 90247443
Bone marrow failure 158.30 13.58 148 60731 32073 90535495
Wound 157.86 13.58 12 60867 302968 90264600
Aortitis 151.42 13.58 50 60829 1300 90566268
Abdominal discomfort 150.85 13.58 66 60813 477262 90090306
Swelling 142.11 13.58 52 60827 419006 90148562
Hypoxia 138.77 13.58 205 60674 72194 90495374
Musculoskeletal stiffness 138.19 13.58 18 60861 296514 90271054
Pericarditis 134.44 13.58 13 60866 270138 90297430
Hypokalaemia 132.22 13.58 280 60599 130836 90436732
Plasma cell myeloma 130.72 13.58 149 60730 40679 90526889
Neuropathy peripheral 130.67 13.58 286 60593 136684 90430884
Helicobacter infection 130.48 13.58 5 60874 226845 90340723
Drug ineffective 130.19 13.58 486 60393 1383812 89183756
Irritable bowel syndrome 124.99 13.58 3 60876 207445 90360123
Type 2 diabetes mellitus 122.22 13.58 3 60876 203241 90364327
Diarrhoea 121.92 13.58 1059 59820 938131 89629437
White blood cell count abnormal 121.88 13.58 71 60808 7433 90560135
Atelectasis 119.67 13.58 112 60767 24297 90543271
Computerised tomogram thorax 117.14 13.58 33 60846 492 90567076
Hepatic enzyme increased 116.92 13.58 48 60831 360688 90206880
Drug hypersensitivity 116.48 13.58 85 60794 463524 90104044
Discomfort 115.74 13.58 22 60857 274313 90293255
Therapeutic product effect decreased 115.54 13.58 23 60856 277548 90290020
Fibromyalgia 113.87 13.58 6 60873 206263 90361305
Aplastic anaemia 113.39 13.58 84 60795 13185 90554383
Injury 111.31 13.58 5 60874 197344 90370224
Infusion related reaction 107.85 13.58 74 60805 416706 90150862
Pain 105.47 13.58 332 60547 996009 89571559
Pneumonia 105.40 13.58 761 60118 637298 89930270
Folliculitis 103.89 13.58 9 60870 204344 90363224
Asthma 103.04 13.58 19 60860 242141 90325427
Blood cholesterol increased 100.91 13.58 11 60868 208001 90359567
Disease recurrence 100.10 13.58 125 60754 37528 90530040
Multiple organ dysfunction syndrome 99.92 13.58 171 60708 68165 90499403
Peripheral sensory neuropathy 98.57 13.58 67 60812 9183 90558385
Rheumatoid factor positive 97.96 13.58 4 60875 171646 90395922
Hypoalbuminaemia 97.92 13.58 83 60796 15814 90551754
Febrile bone marrow aplasia 97.78 13.58 68 60811 9670 90557898
Treatment failure 95.97 13.58 42 60837 303886 90263682
Fall 95.32 13.58 110 60769 481700 90085868
Impaired healing 90.25 13.58 23 60856 234176 90333392
Capillary leak syndrome 87.71 13.58 41 60838 2726 90564842
Sleep disorder 87.62 13.58 14 60865 198016 90369552
Immune effector cell-associated neurotoxicity syndrome 86.93 13.58 52 60827 5716 90561852
Cytomegalovirus infection 86.71 13.58 98 60781 26504 90541064
Peripheral swelling 86.45 13.58 90 60789 413016 90154552
Weight increased 86.39 13.58 92 60787 417835 90149733
Acute respiratory distress syndrome 85.64 13.58 101 60778 28585 90538983
Mobility decreased 85.12 13.58 31 60848 250703 90316865
Clostridium difficile infection 84.86 13.58 113 60766 36132 90531436
Human bocavirus infection 84.51 13.58 25 60854 447 90567121
Nasopharyngitis 81.52 13.58 92 60787 407012 90160556
Myelodysplastic syndrome 80.34 13.58 84 60795 20819 90546749
Ill-defined disorder 79.74 13.58 14 60865 184877 90382691
Blood magnesium decreased 76.91 13.58 72 60807 15621 90551947
Leukocytosis 76.24 13.58 99 60780 30891 90536677
Sinusitis 76.08 13.58 71 60808 343017 90224551
Cytopenia 75.96 13.58 75 60804 17374 90550194
Liver injury 75.59 13.58 12 60867 170555 90397013
Wheezing 74.98 13.58 33 60846 238047 90329521
Colony stimulating factor therapy 73.92 13.58 22 60857 402 90567166
Hypersensitivity 73.60 13.58 120 60759 454557 90113011
Pseudomonal sepsis 73.31 13.58 42 60837 4260 90563308
Tonsillar disorder 72.10 13.58 28 60851 1174 90566394
Joint range of motion decreased 71.67 13.58 5 60874 135638 90431930
Neurotoxicity 71.53 13.58 80 60799 21387 90546181
Osteoarthritis 70.25 13.58 22 60857 195708 90371860
Arthralgia 69.80 13.58 278 60601 778244 89789324
Depression 69.28 13.58 60 60819 300541 90267027
Acute myeloid leukaemia recurrent 66.82 13.58 31 60848 2026 90565542
Haemophagocytic lymphohistiocytosis 66.47 13.58 66 60813 15393 90552175
Pleural effusion 66.08 13.58 195 60684 111796 90455772
Blister 64.94 13.58 46 60833 254952 90312616
Escherichia bacteraemia 64.60 13.58 43 60836 5692 90561876
Condition aggravated 63.84 13.58 197 60682 595348 89972220
Gait disturbance 62.48 13.58 50 60829 260446 90307122
Palmar-plantar erythrodysaesthesia syndrome 62.00 13.58 85 60794 27938 90539630
Bronchopulmonary aspergillosis 61.12 13.58 55 60824 11343 90556225
Hypertension 60.70 13.58 136 60743 457396 90110172
Colitis 59.91 13.58 140 60739 69802 90497766
Acute febrile neutrophilic dermatosis 58.79 13.58 34 60845 3511 90564057
Heart rate abnormal 58.33 13.58 41 60838 5930 90561638
Enterobacter infection 57.25 13.58 30 60849 2553 90565015
Neoplasm progression 56.88 13.58 105 60774 44381 90523187
Lymphadenitis 56.45 13.58 35 60844 4102 90563466
Lymphopenia 56.13 13.58 73 60806 22808 90544760
Clostridium difficile colitis 56.08 13.58 79 60800 26627 90540941
Constipation 56.06 13.58 351 60528 280044 90287524
Bacteraemia 56.04 13.58 72 60807 22228 90545340
Psoriasis 55.97 13.58 15 60864 147739 90419829
Sciatica 55.77 13.58 3 60876 101379 90466189
Alveolitis 55.55 13.58 31 60848 2990 90564578
Urticaria 54.94 13.58 78 60801 312656 90254912
Nausea 54.71 13.58 1047 59832 1109269 89458299
Anxiety 54.68 13.58 77 60802 309695 90257873
Human herpesvirus 6 infection 54.49 13.58 32 60847 3400 90564168
Hypophosphataemia 54.08 13.58 58 60821 14796 90552772
Road traffic accident 53.98 13.58 5 60874 107621 90459947
Rhinovirus infection 53.78 13.58 39 60840 5924 90561644
Agranulocytosis 53.02 13.58 89 60790 34913 90532655
Headache 52.46 13.58 352 60527 862394 89705174
Crystal nephropathy 52.44 13.58 22 60857 1129 90566439
Acute graft versus host disease in skin 51.99 13.58 35 60844 4721 90562847
Excessive eye blinking 51.92 13.58 23 60856 1349 90566219
Cystitis haemorrhagic 51.88 13.58 37 60842 5476 90562092
Neutrophil count abnormal 51.51 13.58 33 60846 4095 90563473
Neutropenic colitis 51.40 13.58 33 60846 4110 90563458
Venoocclusive liver disease 51.34 13.58 38 60841 5955 90561613
Secondary immunodeficiency 50.88 13.58 26 60853 2100 90565468
Neoplasm recurrence 50.73 13.58 30 60849 3229 90564339
Therapeutic product effect incomplete 50.66 13.58 34 60845 193862 90373706
Intentional product use issue 50.31 13.58 43 60836 216849 90350719
Acute lymphocytic leukaemia recurrent 50.25 13.58 28 60851 2693 90564875
Acute lymphocytic leukaemia 49.06 13.58 28 60851 2820 90564748
Contusion 48.91 13.58 58 60821 251158 90316410
Herpes simplex 48.53 13.58 46 60833 10135 90557433
Wound infection 48.25 13.58 7 60872 106395 90461173
Gastroenteritis norovirus 48.16 13.58 26 60853 2350 90565218
Stem cell transplant 47.69 13.58 25 60854 2129 90565439
Lymphadenopathy 47.54 13.58 99 60780 45676 90521892
Cystitis bacterial 47.53 13.58 15 60864 336 90567232
Cytomegalovirus viraemia 47.52 13.58 40 60839 7546 90560022
Hypercholesterolaemia 47.26 13.58 6 60873 100886 90466682
Bacterial infection 47.24 13.58 68 60811 23376 90544192
Migraine 46.33 13.58 36 60843 190356 90377212
Blood stem cell harvest failure 46.30 13.58 11 60868 79 90567489
Product use issue 46.28 13.58 95 60784 329824 90237744
Hemianopia 45.63 13.58 24 60855 2058 90565510
Cytomegalovirus test positive 45.53 13.58 29 60850 3562 90564006
Gait inability 45.00 13.58 21 60858 146435 90421133
Respiratory failure 45.00 13.58 178 60701 118240 90449328
Thrombotic microangiopathy 44.64 13.58 54 60825 15689 90551879
Leukaemoid reaction 44.61 13.58 13 60866 220 90567348
Loss of personal independence in daily activities 44.22 13.58 18 60861 136087 90431481
Pharyngeal inflammation 44.11 13.58 19 60860 1041 90566527
Pseudomonas infection 43.81 13.58 52 60827 14813 90552755
Toxicity to various agents 43.75 13.58 79 60800 287767 90279801
Alopecia 43.50 13.58 178 60701 494893 90072675
Memory impairment 43.47 13.58 41 60838 197203 90370365
Nasal disorder 42.78 13.58 27 60852 3265 90564303
Bone marrow disorder 42.26 13.58 26 60853 3006 90564562
Haemoglobin decreased 41.72 13.58 217 60662 161739 90405829
Pneumatosis intestinalis 41.71 13.58 27 60852 3410 90564158
Graft versus host disease in skin 41.27 13.58 28 60851 3825 90563743
Graft versus host disease 41.13 13.58 38 60841 8106 90559462
Somnolence 40.99 13.58 48 60831 209036 90358532
Drug abuse 40.83 13.58 4 60875 82343 90485225
Overdose 40.73 13.58 28 60851 157681 90409887
Blood disorder 40.61 13.58 37 60842 7753 90559815
Autoimmune disorder 40.04 13.58 3 60876 76741 90490827
Confusional state 39.74 13.58 130 60749 386075 90181493
Pulmonary haemorrhage 39.72 13.58 37 60842 7976 90559592
Rash maculo-papular 39.59 13.58 86 60793 40847 90526721
Acute graft versus host disease 38.80 13.58 31 60848 5437 90562131
Cytomegalovirus infection reactivation 38.63 13.58 36 60843 7764 90559804
Pruritus 38.04 13.58 211 60668 541314 90026254
Thrombosis 38.03 13.58 122 60757 73129 90494439
Immune reconstitution inflammatory syndrome 37.89 13.58 34 60845 6985 90560583
Epistaxis 37.35 13.58 134 60745 84991 90482577
Musculoskeletal pain 37.27 13.58 36 60843 171215 90396353
Inflammation 37.20 13.58 39 60840 178553 90389015
Fluid intake reduced 37.09 13.58 27 60852 4125 90563443
Cerebellar stroke 36.96 13.58 13 60866 411 90567157
Staphylococcal sepsis 36.58 13.58 38 60841 9345 90558223
Bacillus infection 36.04 13.58 16 60863 943 90566625
Night sweats 35.81 13.58 21 60858 128745 90438823
Suicidal ideation 35.56 13.58 4 60875 73851 90493717
Pulmonary fibrosis 35.27 13.58 14 60865 107489 90460079
Deep vein thrombosis 35.03 13.58 138 60741 91482 90476086
Ejection fraction decreased 34.87 13.58 63 60816 26190 90541378
Pneumonia moraxella 34.64 13.58 8 60871 50 90567518
Acute graft versus host disease in intestine 34.60 13.58 20 60859 2063 90565505
Engraft failure 34.55 13.58 12 60867 365 90567203
Diffuse large B-cell lymphoma refractory 34.55 13.58 19 60860 1781 90565787
Plasma cells increased 34.38 13.58 9 60870 100 90567468
Bladder hypertrophy 34.01 13.58 13 60866 522 90567046
Osteolysis 33.80 13.58 24 60855 3526 90564042
Disseminated intravascular coagulation 32.93 13.58 55 60824 21483 90546085
Blood lactate dehydrogenase increased 32.89 13.58 61 60818 25871 90541697
Lower respiratory tract infection 32.80 13.58 75 60804 250584 90316984
Chronic graft versus host disease 32.69 13.58 25 60854 4114 90563454
Coagulopathy 32.36 13.58 57 60822 23232 90544336
Arthritis 32.16 13.58 39 60840 167276 90400292
Live birth 31.97 13.58 7 60872 79100 90488468
Enteritis 31.90 13.58 37 60842 10284 90557284
Toxic erythema of chemotherapy 31.69 13.58 10 60869 224 90567344
Vomiting 31.68 13.58 722 60157 787571 89779997
Prescribed underdose 31.64 13.58 6 60873 75013 90492555
Back pain 31.63 13.58 339 60540 316836 90250732
Folate deficiency 31.54 13.58 22 60857 3143 90564425
Brain oedema 31.54 13.58 48 60831 17337 90550231
Exposure during pregnancy 31.46 13.58 71 60808 238339 90329229
Pulmonary embolism 31.44 13.58 172 60707 130648 90436920
Hypocalcaemia 31.16 13.58 80 60799 42288 90525280
Muscular weakness 31.14 13.58 57 60822 206609 90360959
Escherichia sepsis 31.06 13.58 28 60851 5788 90561780
Hypotension 30.71 13.58 344 60535 325053 90242515
White blood cell count increased 30.48 13.58 107 60772 67134 90500434
Blood culture positive 30.25 13.58 26 60853 5046 90562522
Blood pressure increased 30.07 13.58 54 60825 197163 90370405
Colitis ulcerative 29.69 13.58 3 60876 60263 90507305
Hypoaesthesia 29.47 13.58 110 60769 314100 90253468
Stress 29.46 13.58 9 60870 81386 90486182
Maternal exposure before pregnancy 29.43 13.58 37 60842 11176 90556392
Device related infection 29.43 13.58 58 60821 25728 90541840
Injection site swelling 29.42 13.58 3 60876 59836 90507732
Renal failure 29.33 13.58 169 60710 130838 90436730
Breast cancer metastatic 29.19 13.58 43 60836 15089 90552479
Drug interaction 29.16 13.58 92 60787 276361 90291207
Dehydration 29.15 13.58 227 60652 194220 90373348
Radiation fibrosis - lung 29.14 13.58 7 60872 53 90567515
Streptococcal sepsis 29.08 13.58 22 60857 3562 90564006
Injection site reaction 28.60 13.58 13 60866 92067 90475501
Cholangitis infective 28.49 13.58 11 60868 454 90567114
Metastases to liver 28.40 13.58 61 60818 28746 90538822
Amnesia 28.37 13.58 19 60860 108486 90459082
Venous thrombosis 28.28 13.58 26 60853 5511 90562057
Maternal exposure during pregnancy 28.24 13.58 135 60744 359928 90207640
Balance disorder 28.19 13.58 15 60864 97065 90470503
Epilepsy 28.15 13.58 10 60869 82196 90485372
White blood cell disorder 28.14 13.58 20 60859 2944 90564624
Osteoporosis 27.91 13.58 15 60864 96516 90471052
Enterococcal infection 27.88 13.58 34 60845 9957 90557611
Autoimmune haemolytic anaemia 27.85 13.58 26 60853 5619 90561949
Syphilis 27.70 13.58 9 60870 222 90567346
Dry mouth 27.52 13.58 51 60828 184008 90383560
Injection site erythema 27.48 13.58 16 60863 98486 90469082
Hyperglycaemia 27.47 13.58 86 60793 50884 90516684
Platelet count abnormal 27.45 13.58 23 60856 4312 90563256
Drug effective for unapproved indication 27.22 13.58 30 60849 7888 90559680
Pneumonitis 27.08 13.58 78 60801 44092 90523476
Foot deformity 26.86 13.58 4 60875 59647 90507921
Splenomegaly 26.79 13.58 38 60841 12886 90554682
Gastrooesophageal reflux disease 26.77 13.58 44 60835 166293 90401275
Diffuse large B-cell lymphoma 26.73 13.58 31 60848 8614 90558954
Toxic epidermal necrolysis 26.64 13.58 64 60815 32464 90535104
Viral haemorrhagic cystitis 26.58 13.58 15 60864 1478 90566090
Chronic lymphocytic leukaemia recurrent 26.46 13.58 10 60869 389 90567179
Muscle spasms 26.44 13.58 84 60795 251799 90315769
Chills 26.20 13.58 165 60714 131816 90435752
Product dose omission issue 26.13 13.58 104 60775 291583 90275985
Hyperbilirubinaemia 26.02 13.58 39 60840 13897 90553671
Interstitial lung disease 25.98 13.58 111 60768 76294 90491274
Klebsiella bacteraemia 25.79 13.58 18 60861 2574 90564994
Acute graft versus host disease in liver 25.72 13.58 12 60867 794 90566774
Aspergilloma 25.72 13.58 9 60870 280 90567288
Dizziness 25.46 13.58 263 60616 589021 89978547
Dermatitis bullous 25.44 13.58 33 60846 10283 90557285
Myelodysplastic syndrome transformation 25.27 13.58 10 60869 441 90567127
Biliary tract infection 25.20 13.58 12 60867 832 90566736
Splenic rupture 25.02 13.58 14 60865 1357 90566211
Bone marrow transplant 24.98 13.58 12 60867 848 90566720
Product quality issue 24.95 13.58 11 60868 79314 90488254
Product storage error 24.90 13.58 47 60832 20194 90547374
Fibrosis 24.83 13.58 25 60854 5927 90561641
Drug-induced liver injury 24.73 13.58 15 60864 90303 90477265
BK virus infection 24.70 13.58 22 60857 4476 90563092
COVID-19 pneumonia 24.62 13.58 44 60835 18133 90549435
Embolism 24.43 13.58 31 60848 9450 90558118
Rash scarlatiniform 24.30 13.58 8 60871 206 90567362
Polyneuropathy 23.91 13.58 45 60834 19296 90548272
Full blood count decreased 23.87 13.58 58 60821 29631 90537937
Chemotherapy 23.78 13.58 15 60864 1812 90565756
Taste disorder 23.77 13.58 6 60873 61540 90506028
Hydronephrosis 23.58 13.58 35 60844 12367 90555201
Symmetrical drug-related intertriginous and flexural exanthema 23.51 13.58 12 60867 967 90566601
Enterocolitis 23.47 13.58 32 60847 10458 90557110
Biliary sepsis 23.43 13.58 12 60867 974 90566594
Insomnia 23.34 13.58 130 60749 333344 90234224
Tumour necrosis 23.26 13.58 12 60867 989 90566579
Cytogenetic abnormality 23.21 13.58 10 60869 548 90567020
Hyperchlorhydria 22.95 13.58 15 60864 1926 90565642
Metastases to bone 22.88 13.58 52 60827 25453 90542115
Aplasia 22.88 13.58 20 60859 3971 90563597
Candida test positive 22.83 13.58 12 60867 1027 90566541
Syncope 22.80 13.58 160 60719 132503 90435065
Peripheral motor neuropathy 22.72 13.58 15 60864 1958 90565610
Malignant neoplasm progression 22.72 13.58 136 60743 106734 90460834
Candida infection 22.70 13.58 62 60817 33995 90533573
Ultrasound foetal abnormal 22.65 13.58 7 60872 146 90567422
Cardiac failure 22.42 13.58 138 60741 109358 90458210
Gamma-glutamyltransferase increased 22.29 13.58 66 60813 37886 90529682
Blood pressure systolic increased 21.94 13.58 6 60873 58339 90509229
Haematotoxicity 21.88 13.58 34 60845 12501 90555067
Alpha haemolytic streptococcal infection 21.83 13.58 14 60865 1740 90565828
Follicular lymphoma stage IV 21.68 13.58 5 60874 31 90567537
Kidney malrotation 21.68 13.58 5 60874 31 90567537
Pneumocystis jirovecii pneumonia 21.57 13.58 46 60833 21570 90545998
Nail bed inflammation 21.49 13.58 14 60865 1787 90565781
Infective aortitis 21.41 13.58 5 60874 33 90567535
Pseudomembranous colitis 21.40 13.58 19 60860 3849 90563719
Pneumonia fungal 21.39 13.58 25 60854 7006 90560562
Back injury 21.29 13.58 3 60876 46619 90520949
Nasal congestion 21.28 13.58 15 60864 83399 90484169
Vulvovaginal candidiasis 21.27 13.58 19 60860 3881 90563687
Oral candidiasis 21.15 13.58 62 60817 35393 90532175
Injection site pain 21.11 13.58 54 60825 173645 90393923
Onycholysis 21.06 13.58 15 60864 2215 90565353
Hypomagnesaemia 21.00 13.58 62 60817 35526 90532042
Systemic candida 21.00 13.58 21 60858 4938 90562630
Ascites 20.80 13.58 75 60804 47665 90519903
Haemolytic anaemia 20.80 13.58 32 60847 11665 90555903
Abdominal wall wound 20.79 13.58 6 60873 98 90567470
Sinusitis fungal 20.39 13.58 14 60865 1950 90565618
Myeloblast percentage decreased 20.36 13.58 5 60874 42 90567526
Face oedema 20.32 13.58 47 60832 23271 90544297
Skin maceration 20.22 13.58 7 60872 211 90567357
Joint dislocation 20.05 13.58 3 60876 44579 90522989
Necrotising colitis 20.00 13.58 12 60867 1326 90566242
Dry eye 19.92 13.58 7 60872 57924 90509644
Cellulitis 19.90 13.58 117 60762 91220 90476348
Atrial fibrillation 19.48 13.58 155 60724 133456 90434112
Norovirus test positive 19.47 13.58 7 60872 236 90567332
Metastases to lymph nodes 19.43 13.58 31 60848 11658 90555910
Haemorrhage urinary tract 19.29 13.58 11 60868 1106 90566462
Muscle twitching 19.16 13.58 47 60832 24155 90543413
Bone marrow necrosis 19.16 13.58 6 60873 131 90567437
Tumour lysis syndrome 19.12 13.58 30 60849 11122 90556446
Abdominal sepsis 19.04 13.58 12 60867 1447 90566121
Neutropenic infection 19.03 13.58 13 60866 1796 90565772
Tissue infiltration 18.98 13.58 10 60869 860 90566708
Bone erosion 18.94 13.58 6 60873 53015 90514553
Syringe issue 18.92 13.58 18 60861 3984 90563584
Adult T-cell lymphoma/leukaemia 18.91 13.58 7 60872 257 90567311
Paronychia 18.80 13.58 25 60854 7981 90559587
Alanine aminotransferase increased 18.76 13.58 140 60739 118198 90449370
Nasal mucosal disorder 18.72 13.58 13 60866 1844 90565724
Thrombocytopenic purpura 18.69 13.58 13 60866 1848 90565720
Electrolyte imbalance 18.68 13.58 46 60833 23699 90543869
Blood pressure fluctuation 18.60 13.58 6 60873 52407 90515161
Ovarian disorder 18.59 13.58 10 60869 897 90566671
Allogenic stem cell transplantation 18.51 13.58 6 60873 147 90567421
Aplasia pure red cell 18.41 13.58 20 60859 5174 90562394
Transfusion 18.36 13.58 38 60841 17450 90550118
Chronic graft versus host disease in skin 18.22 13.58 11 60868 1229 90566339
Terminal ileitis 18.14 13.58 11 60868 1239 90566329
Feeling abnormal 18.09 13.58 55 60824 167180 90400388
Parainfluenzae virus infection 18.01 13.58 15 60864 2788 90564780
PSTPIP1-associated myeloid-related proteinaemia inflammatory syndrome 17.91 13.58 4 60875 21 90567547
Laryngitis 17.68 13.58 6 60873 50747 90516821
Candida sepsis 17.67 13.58 12 60867 1641 90565927
Dysgeusia 17.59 13.58 76 60803 52484 90515084
Nephropathy toxic 17.56 13.58 31 60848 12657 90554911
Graft versus host disease in gastrointestinal tract 17.52 13.58 18 60861 4370 90563198
Neuroblastoma recurrent 17.39 13.58 6 60873 179 90567389
Hilar lymphadenopathy 17.38 13.58 11 60868 1337 90566231
Decreased appetite 17.35 13.58 352 60527 376188 90191380
Abdominal pain 17.28 13.58 367 60512 395354 90172214
Subclavian vein thrombosis 17.20 13.58 13 60866 2103 90565465
Rash pustular 17.18 13.58 24 60855 8025 90559543
Gene mutation 17.12 13.58 13 60866 2117 90565451
Aspergillus infection 17.03 13.58 28 60851 10795 90556773
Colitis ischaemic 16.87 13.58 30 60849 12316 90555252
Klebsiella sepsis 16.87 13.58 12 60867 1769 90565799
Lymph node pain 16.87 13.58 12 60867 1769 90565799
Blood bilirubin 16.84 13.58 3 60876 3 90567565
Onychomadesis 16.80 13.58 5 60874 45993 90521575
Pain in extremity 16.71 13.58 208 60671 450321 90117247
Acute interstitial pneumonitis 16.70 13.58 9 60870 810 90566758
Abdominal pain upper 16.68 13.58 143 60736 332531 90235037
Tumour marker increased 16.59 13.58 20 60859 5787 90561781
Post procedural diarrhoea 16.49 13.58 7 60872 370 90567198
Bone marrow infiltration 16.47 13.58 9 60870 833 90566735
Aspartate aminotransferase increased 16.44 13.58 122 60757 102815 90464753
Fluid retention 16.43 13.58 21 60858 88070 90479498
Joint stiffness 16.29 13.58 17 60862 78025 90489543
Plasma cell myeloma recurrent 16.26 13.58 17 60862 4211 90563357
Posterior reversible encephalopathy syndrome 16.24 13.58 42 60837 22297 90545271
Hepatic failure 16.13 13.58 61 60818 39667 90527901
Malaise 16.05 13.58 287 60592 585699 89981869
Cough 16.04 13.58 342 60537 368620 90198948
Bronchitis 16.04 13.58 51 60828 152876 90414692
Ear infection 15.96 13.58 14 60865 69761 90497807
Psychiatric decompensation 15.93 13.58 12 60867 1931 90565637
Nail disorder 15.90 13.58 10 60869 59057 90508511
Bone marrow leukaemic cell infiltration 15.57 13.58 4 60875 41 90567527
Hepatic function abnormal 15.54 13.58 67 60812 46221 90521347
Naevus haemorrhage 15.52 13.58 5 60874 120 90567448
Chronic obstructive pulmonary disease 15.50 13.58 16 60863 73813 90493755
Granulomatous liver disease 15.47 13.58 9 60870 940 90566628
Encephalopathy 15.42 13.58 67 60812 46377 90521191
Choriocarcinoma 15.40 13.58 4 60875 43 90567525
Enterocolitis infectious 15.37 13.58 12 60867 2035 90565533
Premature delivery 15.31 13.58 59 60820 38703 90528865
Relapsing fever 15.31 13.58 6 60873 258 90567310
Multiple sclerosis relapse 15.30 13.58 8 60871 52297 90515271
Myocardial infarction 15.28 13.58 30 60849 105942 90461626
Splenic haematoma 15.25 13.58 5 60874 127 90567441
Tonsillitis 15.20 13.58 21 60858 6948 90560620
Blood potassium decreased 15.20 13.58 68 60811 47659 90519909
Ileus 15.13 13.58 34 60845 16512 90551056
Hepatosplenomegaly 15.12 13.58 14 60865 2995 90564573
Liver function test increased 15.04 13.58 21 60858 84834 90482734
Granulocytopenia 14.95 13.58 20 60859 6421 90561147
Haemoglobin abnormal 14.90 13.58 21 60858 7079 90560489
Engraftment syndrome 14.88 13.58 8 60871 717 90566851
Illness 14.82 13.58 20 60859 81949 90485619
Pancreatitis 14.81 13.58 15 60864 69811 90497757
Radiation oesophagitis 14.80 13.58 7 60872 478 90567090
Systemic inflammatory response syndrome 14.77 13.58 20 60859 6496 90561072
Diarrhoea haemorrhagic 14.69 13.58 26 60853 10637 90556931
Neutrophil count increased 14.66 13.58 37 60842 19353 90548215
Delirium 14.65 13.58 30 60849 104329 90463239
Sedation 14.65 13.58 7 60872 48164 90519404
Myelosuppression 14.62 13.58 73 60806 53518 90514050
Immune-mediated enterocolitis 14.61 13.58 17 60862 4740 90562828
Therapy partial responder 14.56 13.58 40 60839 22003 90545565
Cerebrovascular accident 14.55 13.58 39 60840 123494 90444074
Marrow hyperplasia 14.54 13.58 8 60871 751 90566817
Urosepsis 14.50 13.58 39 60840 21193 90546375
Chronic lymphocytic leukaemia 14.50 13.58 14 60865 3156 90564412
Bacterial diarrhoea 14.43 13.58 5 60874 151 90567417
Varicose vein 14.39 13.58 21 60858 7306 90560262
Sinus tachycardia 14.35 13.58 47 60832 28466 90539102
Relapsing-remitting multiple sclerosis 14.15 13.58 8 60871 791 90566777
Device mechanical issue 14.07 13.58 9 60870 1114 90566454
Craniocerebral injury 14.03 13.58 14 60865 3284 90564284
Medication error 13.98 13.58 22 60857 84630 90482938
Visual impairment 13.98 13.58 44 60835 132321 90435247
Second primary malignancy 13.90 13.58 25 60854 10353 90557215
Pericarditis fungal 13.88 13.58 4 60875 65 90567503
Blood phosphorus decreased 13.84 13.58 17 60862 5017 90562551
Metastases to central nervous system 13.82 13.58 34 60845 17508 90550060
Plasma cell leukaemia 13.81 13.58 9 60870 1149 90566419
Escherichia infection 13.81 13.58 32 60847 15863 90551705
Vascular device infection 13.78 13.58 27 60852 11925 90555643
Paraesthesia 13.74 13.58 105 60774 250221 90317347
Blood bilirubin abnormal 13.65 13.58 11 60868 1953 90565615
Nephrolithiasis 13.65 13.58 8 60871 49077 90518491
Tachycardia 13.65 13.58 164 60715 157509 90410059
Soft tissue infection 13.64 13.58 13 60866 2884 90564684

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2280.68 13.17 1866 51414 183837 42384218
Neutropenia 707.89 13.17 1045 52235 198386 42369669
Pancytopenia 381.00 13.17 592 52688 117151 42450904
Thrombocytopenia 359.77 13.17 757 52523 189522 42378533
Pyrexia 268.52 13.17 1086 52194 392956 42175099
Bone pain 256.35 13.17 223 53057 23569 42544486
Neutrophil count decreased 246.75 13.17 348 52932 63067 42504988
White blood cell count decreased 235.22 13.17 462 52818 109934 42458121
Bone marrow failure 209.73 13.17 232 53048 32861 42535194
Cytokine release syndrome 204.59 13.17 265 53015 44262 42523793
Sepsis 168.82 13.17 590 52690 198744 42369311
Septic shock 157.02 13.17 351 52929 91321 42476734
Mucosal inflammation 156.19 13.17 246 53034 49128 42518927
Haematotoxicity 151.80 13.17 119 53161 10866 42557189
Acute myeloid leukaemia recurrent 142.29 13.17 75 53205 3437 42564618
Lymphoid tissue hypoplasia 134.47 13.17 48 53232 830 42567225
Thymus hypoplasia 131.54 13.17 47 53233 815 42567240
Drug interaction 130.37 13.17 87 53193 266912 42301143
Platelet count decreased 128.44 13.17 423 52857 138158 42429897
Leukopenia 126.61 13.17 285 52995 74461 42493594
Acute myeloid leukaemia 123.99 13.17 146 53134 22110 42545945
Clostridium difficile colitis 122.71 13.17 142 53138 21110 42546945
Myelodysplastic syndrome 118.16 13.17 144 53136 22601 42545454
Neutropenic colitis 110.06 13.17 69 53211 4401 42563654
Neutropenic sepsis 99.61 13.17 111 53169 15835 42552220
Febrile bone marrow aplasia 96.88 13.17 89 53191 10092 42557963
Pneumonia 95.30 13.17 873 52407 421276 42146779
Disseminated aspergillosis 87.74 13.17 43 53237 1687 42566368
Toxicity to various agents 86.94 13.17 95 53185 229041 42339014
Lymphopenia 86.23 13.17 120 53160 21443 42546612
Multiple organ dysfunction syndrome 81.73 13.17 287 52993 96748 42471307
Cytomegalovirus viraemia 78.55 13.17 80 53200 10297 42557758
Acute graft versus host disease 78.53 13.17 72 53208 8143 42559912
Escherichia bacteraemia 78.18 13.17 59 53221 5090 42562965
Anaemia 78.12 13.17 608 52672 279670 42288385
Graft versus host disease 77.36 13.17 88 53192 12837 42555218
Hypoalbuminaemia 76.52 13.17 96 53184 15514 42552541
Skin toxicity 75.82 13.17 64 53216 6485 42561570
Drug ineffective 75.48 13.17 471 52809 629726 41938329
Colony stimulating factor therapy 72.09 13.17 21 53259 181 42567874
Somnolence 71.46 13.17 44 53236 141061 42426994
Aplastic anaemia 68.56 13.17 81 53199 12303 42555752
Fungal infection 67.55 13.17 102 53178 19620 42548435
Overdose 63.53 13.17 26 53254 105238 42462817
Splenic rupture 63.41 13.17 34 53246 1613 42566442
Face oedema 62.19 13.17 81 53199 13585 42554470
Agranulocytosis 61.30 13.17 125 53155 30487 42537568
Fall 61.03 13.17 126 53154 234394 42333661
Aplasia 59.53 13.17 49 53231 4794 42563261
Neutropenic infection 59.32 13.17 34 53246 1839 42566216
Plasma cell myeloma 58.90 13.17 161 53119 47417 42520638
Escherichia infection 57.32 13.17 71 53209 11325 42556730
Bacterial infection 57.20 13.17 115 53165 27764 42540291
Cytomegalovirus infection 56.68 13.17 125 53155 32181 42535874
Tumour lysis syndrome 55.89 13.17 100 53180 22131 42545924
Dizziness 55.17 13.17 146 53134 249108 42318947
Acute graft versus host disease in skin 53.96 13.17 56 53224 7368 42560687
Anxiety 53.36 13.17 42 53238 118518 42449537
Pneumonia klebsiella 52.43 13.17 43 53237 4186 42563869
Blood pressure increased 51.29 13.17 32 53248 101896 42466159
Cytopenia 50.94 13.17 84 53196 17413 42550642
Venoocclusive liver disease 49.92 13.17 63 53217 10239 42557816
Cystitis haemorrhagic 49.21 13.17 53 53227 7276 42560779
Venoocclusive disease 48.94 13.17 40 53240 3875 42564180
Dyspnoea 48.66 13.17 339 52941 442282 42125773
Cytomegalovirus test positive 47.53 13.17 41 53239 4278 42563777
Inappropriate schedule of product administration 47.03 13.17 31 53249 95871 42472184
Intentional overdose 46.59 13.17 5 53275 51451 42516604
Stomatitis 45.96 13.17 153 53127 50176 42517879
Headache 45.85 13.17 150 53130 239219 42328836
Drug hypersensitivity 44.98 13.17 35 53245 99354 42468701
Infection 44.80 13.17 266 53014 111802 42456253
Bronchopulmonary aspergillosis 44.55 13.17 84 53196 19345 42548710
Splenomegaly 44.55 13.17 78 53202 16969 42551086
Myocardial infarction 44.17 13.17 54 53226 123955 42444100
Pneumonia fungal 42.85 13.17 55 53225 9091 42558964
Loss of personal independence in daily activities 42.27 13.17 6 53274 49810 42518245
Stress 40.79 13.17 4 53276 44208 42523847
Suicide attempt 40.43 13.17 5 53275 46095 42521960
Herpes simplex 40.26 13.17 47 53233 7048 42561007
Femoroacetabular impingement 39.80 13.17 7 53273 0 42568055
Bacteraemia 39.61 13.17 93 53187 24947 42543108
Neuropathy peripheral 39.58 13.17 240 53040 101613 42466442
Platelet transfusion 38.84 13.17 25 53255 1669 42566386
Rheumatoid arthritis 38.74 13.17 4 53276 42436 42525619
Musculoskeletal stiffness 38.71 13.17 12 53268 57753 42510302
Streptococcal bacteraemia 38.71 13.17 30 53250 2692 42565363
Aortitis 38.42 13.17 18 53262 638 42567417
Candida infection 38.34 13.17 84 53196 21526 42546529
Neutrophil count abnormal 38.23 13.17 30 53250 2741 42565314
Enterococcal infection 38.05 13.17 60 53220 11979 42556076
Gait disturbance 37.80 13.17 40 53240 97960 42470095
Chronic graft versus host disease 37.72 13.17 42 53238 5983 42562072
Escherichia sepsis 37.60 13.17 41 53239 5706 42562349
Rhabdomyolysis 37.20 13.17 26 53254 77993 42490062
Asthma 36.61 13.17 16 53264 62298 42505757
Cellulitis 36.33 13.17 163 53117 61422 42506633
Pseudomonal sepsis 36.31 13.17 35 53245 4214 42563841
Intentional product misuse 36.20 13.17 16 53264 61884 42506171
Streptococcal infection 35.43 13.17 41 53239 6091 42561964
Off label use 34.84 13.17 1043 52237 637292 41930763
Depression 34.14 13.17 54 53226 111309 42456746
Extramedullary haemopoiesis 33.42 13.17 11 53269 147 42567908
Hypokalaemia 33.12 13.17 177 53103 71544 42496511
Lymphadenopathy 32.77 13.17 104 53176 33261 42534794
Psoriasis 32.74 13.17 10 53270 48594 42519461
Campylobacter gastroenteritis 32.51 13.17 19 53261 1066 42566989
Rash maculo-papular 32.46 13.17 112 53168 37391 42530664
Sleep disorder 32.21 13.17 10 53270 48085 42519970
Joint swelling 32.00 13.17 23 53257 67999 42500056
Pseudomonas infection 31.85 13.17 65 53215 15858 42552197
Staphylococcal bacteraemia 31.84 13.17 53 53227 11068 42556987
Bradycardia 31.74 13.17 36 53244 85448 42482607
Pleural effusion 31.64 13.17 219 53061 96947 42471108
Alpha haemolytic streptococcal infection 31.58 13.17 23 53257 1879 42566176
Diabetes mellitus 31.43 13.17 18 53262 60069 42507986
Chronic kidney disease 31.32 13.17 10 53270 47231 42520824
Pseudomonal bacteraemia 31.05 13.17 25 53255 2371 42565684
Acute graft versus host disease in intestine 30.89 13.17 31 53249 3920 42564135
Product dose omission issue 30.74 13.17 95 53185 154270 42413785
Wheezing 30.73 13.17 15 53265 54766 42513289
Stem cell transplant 30.70 13.17 26 53254 2646 42565409
Pain 30.14 13.17 181 53099 244667 42323388
Aggression 29.90 13.17 9 53271 44154 42523901
Klebsiella infection 29.80 13.17 52 53228 11280 42556775
Drug effective for unapproved indication 29.68 13.17 39 53241 6594 42561461
International normalised ratio increased 28.88 13.17 12 53268 48156 42519899
Tubulointerstitial nephritis 28.72 13.17 3 53277 31545 42536510
Gene mutation 28.36 13.17 21 53259 1760 42566295
Systemic candida 28.14 13.17 34 53246 5285 42562770
Hypertension 27.86 13.17 111 53169 167093 42400962
Cutaneous T-cell lymphoma stage I 27.78 13.17 9 53271 114 42567941
Petechiae 27.59 13.17 48 53232 10387 42557668
Chronic obstructive pulmonary disease 27.58 13.17 23 53257 63091 42504964
Agitation 27.41 13.17 24 53256 64290 42503765
Adenovirus infection 27.37 13.17 38 53242 6771 42561284
Haemophagocytic lymphohistiocytosis 27.01 13.17 66 53214 18156 42549899
Periumbilical abscess 26.59 13.17 8 53272 78 42567977
Neutrophil count increased 26.50 13.17 69 53211 19735 42548320
Visceral leishmaniasis 26.38 13.17 17 53263 1137 42566918
Cerebrovascular accident 26.25 13.17 51 53229 97109 42470946
Arthralgia 26.16 13.17 150 53130 205088 42362967
Meningitis tuberculous 26.09 13.17 14 53266 665 42567390
Hyperkalaemia 25.63 13.17 38 53242 80420 42487635
Diarrhoea 25.58 13.17 755 52525 460094 42107961
Heart rate decreased 25.55 13.17 7 53273 36525 42531530
Cytokine storm 24.86 13.17 15 53265 893 42567162
Condition aggravated 24.65 13.17 208 53072 260546 42307509
Cytogenetic abnormality 24.51 13.17 15 53265 916 42567139
Hypogammaglobulinaemia 24.32 13.17 49 53231 11842 42556213
Pulmonary sarcoidosis 23.95 13.17 14 53266 786 42567269
Hypoglycaemia 23.56 13.17 24 53256 59830 42508225
Bone marrow necrosis 23.18 13.17 10 53270 291 42567764
Aspergillus infection 23.09 13.17 57 53223 15780 42552275
Lactic acidosis 23.04 13.17 14 53266 45247 42522808
Tremor 22.77 13.17 55 53225 96874 42471181
Capillary leak syndrome 22.57 13.17 22 53258 2685 42565370
Flushing 22.56 13.17 9 53271 37019 42531036
Device related infection 22.52 13.17 66 53214 20213 42547842
Blood glucose increased 22.33 13.17 36 53244 73663 42494392
Granulocyte count increased 22.32 13.17 11 53269 437 42567618
Disease progression 22.29 13.17 276 53004 143380 42424675
Serotonin syndrome 22.19 13.17 3 53277 25842 42542213
Migraine 21.70 13.17 3 53277 25411 42542644
Coma 21.62 13.17 21 53259 53533 42514522
Pain in extremity 21.44 13.17 106 53174 150498 42417557
Enterobacter sepsis 21.14 13.17 14 53266 981 42567074
Erectile dysfunction 21.13 13.17 3 53277 24910 42543145
Respiratory failure 21.11 13.17 249 53031 127883 42440172
Pulmonary haemorrhage 21.01 13.17 45 53235 11352 42556703
Herpes simplex encephalitis 20.85 13.17 10 53270 374 42567681
Urinary bladder haematoma 20.82 13.17 5 53275 18 42568037
Ecthyma 20.82 13.17 12 53268 656 42567399
Coronary artery disease 20.62 13.17 22 53258 53698 42514357
Disseminated intravascular coagulation 20.55 13.17 73 53207 24721 42543334
B-lymphocyte count decreased 20.36 13.17 13 53267 856 42567199
Colitis ulcerative 20.32 13.17 4 53276 26171 42541884
Acute lymphocytic leukaemia recurrent 20.19 13.17 24 53256 3667 42564388
Neuroblastoma recurrent 20.18 13.17 10 53270 402 42567653
White blood cell count abnormal 20.02 13.17 24 53256 3701 42564354
White blood cell count increased 19.94 13.17 110 53170 44977 42523078
Plasma cells decreased 19.80 13.17 6 53274 60 42567995
Treatment failure 19.53 13.17 30 53250 62594 42505461
Staphylococcal infection 19.53 13.17 96 53184 37547 42530508
Death 19.51 13.17 746 52534 470439 42097616
Psoriatic arthropathy 19 13.17 4 53276 24963 42543092
Acute febrile neutrophilic dermatosis 18.96 13.17 17 53263 1867 42566188
Colitis 18.88 13.17 111 53169 46461 42521594
Hypogonadism 18.85 13.17 19 53261 2415 42565640
Clostridium bacteraemia 18.76 13.17 8 53272 226 42567829
Medication error 18.71 13.17 9 53271 33145 42534910
Bacterial sepsis 18.70 13.17 31 53249 6451 42561604
Treatment noncompliance 18.70 13.17 12 53268 37660 42530395
Bone marrow transplant rejection 18.57 13.17 8 53272 232 42567823
Acute graft versus host disease in liver 18.40 13.17 17 53263 1941 42566114
Corynebacterium sepsis 18.39 13.17 7 53273 146 42567909
Abdominal discomfort 18.23 13.17 42 53238 75213 42492842
Haematochezia 18.22 13.17 28 53252 58408 42509647
Cognitive disorder 18.21 13.17 10 53270 34162 42533893
Myocardial calcification 18.20 13.17 5 53275 34 42568021
Myelosuppression 18.09 13.17 99 53181 40362 42527693
Desmoplastic small round cell tumour 18.04 13.17 4 53276 9 42568046
Erysipelas 18.02 13.17 30 53250 6266 42561789
Enteritis 18.01 13.17 41 53239 10775 42557280
Incorrect dose administered 17.88 13.17 24 53256 52950 42515105
Speech disorder 17.87 13.17 7 53273 29114 42538941
Large granular lymphocytosis 17.86 13.17 8 53272 255 42567800
Mobility decreased 17.86 13.17 11 53269 35295 42532760
Herpes simplex reactivation 17.86 13.17 10 53270 517 42567538
Enterococcal sepsis 17.77 13.17 17 53263 2027 42566028
Growth of eyelashes 17.65 13.17 6 53274 89 42567966
Adenoviral haemorrhagic cystitis 17.58 13.17 10 53270 533 42567522
Escherichia test positive 17.58 13.17 14 53266 1307 42566748
Confusional state 17.53 13.17 130 53150 167467 42400588
Chest discomfort 17.52 13.17 33 53247 63583 42504472
Paronychia 17.48 13.17 24 53256 4231 42563824
Sleep apnoea syndrome 17.42 13.17 3 53277 21605 42546450
Encephalitis brain stem 17.36 13.17 7 53273 171 42567884
Inadequate osteointegration 17.21 13.17 4 53276 12 42568043
Rectosigmoid cancer metastatic 17.21 13.17 4 53276 12 42568043
Plasmablast count increased 17.07 13.17 5 53275 44 42568011
Epididymitis 17.05 13.17 20 53260 3014 42565041
Staphylococcus test positive 16.98 13.17 22 53258 3670 42564385
Engraftment syndrome 16.95 13.17 14 53266 1376 42566679
Transplant failure 16.91 13.17 23 53257 4021 42564034
Abnormal behaviour 16.83 13.17 6 53274 26445 42541610
Colorectal cancer metastatic 16.82 13.17 12 53268 949 42567106
Gastrooesophageal reflux disease 16.66 13.17 19 53261 45004 42523051
Combined immunodeficiency 16.64 13.17 6 53274 107 42567948
Peripheral T-cell lymphoma unspecified 16.56 13.17 10 53270 596 42567459
Purpura 16.52 13.17 42 53238 11837 42556218
Fungaemia 16.51 13.17 20 53260 3116 42564939
Chills 16.47 13.17 185 53095 93881 42474174
Swelling 16.45 13.17 27 53253 54858 42513197
Pulmonary resection 16.43 13.17 6 53274 111 42567944
Angiodysplasia 16.29 13.17 11 53269 796 42567259
Therapeutic product effect decreased 16.21 13.17 15 53265 39135 42528920
Heart rate increased 16.14 13.17 26 53254 53229 42514826
Avian influenza 16.13 13.17 4 53276 17 42568038
Cardiac failure congestive 16.10 13.17 54 53226 85548 42482507
Acute generalised exanthematous pustulosis 15.92 13.17 34 53246 8561 42559494
Candida test positive 15.85 13.17 9 53271 478 42567577
Myeloid leukaemia 15.83 13.17 9 53271 479 42567576
Cord blood transplant therapy 15.83 13.17 5 53275 58 42567997
Polyserositis 15.80 13.17 8 53272 337 42567718
Cytomegalovirus enteritis 15.76 13.17 10 53270 651 42567404
Pneumonia haemophilus 15.73 13.17 12 53268 1052 42567003
Memory impairment 15.72 13.17 24 53256 50198 42517857
Disturbance in attention 15.54 13.17 9 53271 29857 42538198
Varicose vein 15.53 13.17 14 53266 1548 42566507
Peripheral sensory neuropathy 15.47 13.17 34 53246 8728 42559327
Thrombotic microangiopathy 15.36 13.17 47 53233 14735 42553320
Raoultella ornithinolytica infection 15.25 13.17 5 53275 66 42567989
Erythropenia 15.21 13.17 7 53273 238 42567817
Leukaemia recurrent 15.18 13.17 15 53265 1861 42566194
Pulmonary artery stenosis congenital 15.14 13.17 9 53271 521 42567534
Laryngeal cancer stage IV 15.13 13.17 4 53276 23 42568032
Obstructive airways disorder 15.11 13.17 6 53274 24753 42543302
Cytomegalovirus hepatitis 15.10 13.17 9 53271 524 42567531
Dental restoration failure 14.99 13.17 4 53276 24 42568031
Swollen tongue 14.98 13.17 4 53276 21227 42546828
Therapy partial responder 14.95 13.17 57 53223 19964 42548091
Hallucination 14.83 13.17 31 53249 57476 42510579
Immune effector cell-associated neurotoxicity syndrome 14.81 13.17 35 53245 9426 42558629
Red blood cell count decreased 14.59 13.17 80 53200 32635 42535420
Oesophagitis 14.49 13.17 47 53233 15200 42552855
CSF white blood cell count decreased 14.46 13.17 4 53276 28 42568027
Eosinophilia 14.35 13.17 12 53268 32887 42535168
Gastroenteritis clostridial 14.35 13.17 8 53272 410 42567645
Epistaxis 14.34 13.17 137 53143 66689 42501366
BK virus infection 14.30 13.17 33 53247 8751 42559304
Weight increased 14.24 13.17 78 53202 107905 42460150
Pure white cell aplasia 14.14 13.17 5 53275 84 42567971
Accidental overdose 14.09 13.17 9 53271 28321 42539734
Chemotherapy 13.95 13.17 10 53270 797 42567258
Arthropathy 13.92 13.17 10 53270 29587 42538468
Seizure 13.83 13.17 91 53189 120470 42447585
Pneumonia cytomegaloviral 13.64 13.17 21 53259 4105 42563950
Haemorrhagic necrotic pancreatitis 13.58 13.17 6 53274 185 42567870
Acute lymphocytic leukaemia 13.57 13.17 19 53261 3412 42564643
Epstein-Barr virus associated lymphoproliferative disorder 13.55 13.17 16 53264 2427 42565628
Gastrointestinal ischaemia 13.54 13.17 7 53273 308 42567747
Pneumonia pseudomonal 13.53 13.17 23 53257 4886 42563169
Neurotoxicity 13.49 13.17 62 53218 23589 42544466
Frequent bowel movements 13.38 13.17 5 53275 21402 42546653
Plasma cell myeloma recurrent 13.33 13.17 25 53255 5732 42562323
Diffuse large B-cell lymphoma stage II 13.29 13.17 4 53276 39 42568016
Therapy non-responder 13.29 13.17 113 53167 53246 42514809
Leukaemia 13.29 13.17 25 53255 5747 42562308
Drug-induced liver injury 13.26 13.17 17 53263 38256 42529799
Cardiogenic shock 13.23 13.17 15 53265 35625 42532430
Fusarium infection 13.23 13.17 13 53267 1603 42566452
Insomnia 13.20 13.17 90 53190 118163 42449892

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5136.56 12.27 3294 94985 313473 110177547
Neutropenia 1936.82 12.27 2002 96277 372618 110118402
Thrombocytopenia 1019.05 12.27 1395 96884 347490 110143530
Pancytopenia 863.42 12.27 996 97283 208617 110282403
Pyrexia 742.14 12.27 2104 96175 896161 109594859
Neutrophil count decreased 543.95 12.27 602 97677 120339 110370681
Cytokine release syndrome 535.68 12.27 467 97812 69839 110421181
Bone pain 498.95 12.27 434 97845 64699 110426321
White blood cell count decreased 491.22 12.27 794 97485 228596 110262424
Mucosal inflammation 489.32 12.27 511 97768 95630 110395390
Sepsis 432.19 12.27 920 97359 326426 110164594
Platelet count decreased 402.79 12.27 729 97550 229714 110261306
Anaemia 370.25 12.27 1197 97082 545889 109945131
Neutropenic sepsis 369.24 12.27 267 98012 30479 110460541
Bone marrow failure 331.65 12.27 328 97951 57520 110433500
Septic shock 317.69 12.27 531 97748 156997 110334023
Secondary immunodeficiency 301.31 12.27 124 98155 4552 110486468
Lymphoid tissue hypoplasia 289.48 12.27 92 98187 1573 110489447
Leukopenia 287.35 12.27 492 97787 148299 110342721
Thymus hypoplasia 284.18 12.27 91 98188 1596 110489424
Clostridium difficile colitis 265.46 12.27 256 98023 43522 110447498
Bacterial infection 258.27 12.27 258 98021 45778 110445242
Acute myeloid leukaemia 238.92 12.27 227 98052 37883 110453137
Joint swelling 236.90 12.27 52 98227 442793 110048227
Pneumonia 232.10 12.27 1450 96829 875264 109615756
Pseudomonal sepsis 223.37 12.27 124 98155 8922 110482098
Synovitis 219.44 12.27 5 98274 274087 110216933
Rheumatoid arthritis 205.59 12.27 16 98263 299597 110191423
Acute myeloid leukaemia recurrent 204.03 12.27 97 98182 5042 110485978
Disease progression 196.38 12.27 568 97711 243466 110247554
Arthropathy 195.48 12.27 16 98263 287506 110203514
Febrile bone marrow aplasia 194.62 12.27 145 98134 17320 110473700
Cytomegalovirus viraemia 192.42 12.27 145 98134 17619 110473401
Multiple organ dysfunction syndrome 184.57 12.27 413 97866 151297 110339723
Myelodysplastic syndrome 183.03 12.27 195 98084 37289 110453731
Off label use 178.99 12.27 2075 96204 1498110 108992910
Haematotoxicity 178.78 12.27 149 98130 20933 110470087
Lymphopenia 178.76 12.27 199 98080 39971 110451049
Human bocavirus infection 178.38 12.27 58 98221 1070 110489950
Glossodynia 177.89 12.27 4 98275 222000 110269020
Aortitis 177.49 12.27 67 98212 1948 110489072
Bronchopulmonary aspergillosis 176.10 12.27 172 98107 29691 110461329
Pemphigus 175.41 12.27 3 98276 214567 110276453
Drug hypersensitivity 173.08 12.27 94 98185 453996 110037024
Musculoskeletal stiffness 171.18 12.27 23 98256 279799 110211221
Pain 168.53 12.27 375 97904 954580 109536440
Contraindicated product administered 165.52 12.27 15 98264 248252 110242768
Abdominal discomfort 164.56 12.27 72 98207 393786 110097234
Aplastic anaemia 164.31 12.27 151 98128 24157 110466863
Wound 156.73 12.27 14 98265 234423 110256597
Cystitis bacterial 156.73 12.27 54 98225 1199 110489821
Swelling 156.71 12.27 58 98221 350983 110140037
Systemic lupus erythematosus 155.34 12.27 21 98258 254317 110236703
Plasma cell myeloma 154.14 12.27 232 98047 62704 110428316
Psoriatic arthropathy 152.23 12.27 5 98274 196756 110294264
Drug ineffective 151.67 12.27 767 97512 1519773 108971247
Hypoalbuminaemia 150.86 12.27 156 98123 28818 110462202
Fall 147.69 12.27 192 98087 603290 109887730
Mycobacterium chelonae infection 147.23 12.27 66 98213 2994 110488026
Helicobacter infection 142.96 12.27 4 98275 181873 110309147
Drug abuse 142.90 12.27 3 98276 177408 110313612
Staphylococcal bacteraemia 141.62 12.27 118 98161 16570 110474450
Norovirus test positive 137.82 12.27 46 98233 924 110490096
Human herpesvirus 6 infection 137.77 12.27 81 98198 6500 110484520
Acute graft versus host disease 136.98 12.27 104 98175 12777 110478243
Computerised tomogram thorax abnormal 136.77 12.27 61 98218 2734 110488286
Cytopenia 133.66 12.27 149 98130 29967 110461053
Fibromyalgia 133.45 12.27 4 98275 170905 110320115
Asthma 132.52 12.27 30 98249 250261 110240759
Blood cholesterol increased 132.17 12.27 8 98271 184777 110306243
Drug intolerance 129.35 12.27 103 98176 406409 110084611
Death 129.25 12.27 1061 97218 697808 109793212
Type 2 diabetes mellitus 128.82 12.27 7 98272 177225 110313795
Therapeutic product effect decreased 127.92 12.27 30 98249 244286 110246734
Peripheral swelling 127.77 12.27 103 98176 403931 110087089
Colony stimulating factor therapy 126.34 12.27 39 98240 603 110490417
Anxiety 126.32 12.27 75 98204 345003 110146017
Neutropenic colitis 125.05 12.27 82 98197 7983 110483037
Sleep disorder 124.68 12.27 15 98264 198629 110292391
Disseminated aspergillosis 124.16 12.27 55 98224 2425 110488595
Arthralgia 124.05 12.27 323 97956 779309 109711711
Hypokalaemia 123.63 12.27 400 97879 182048 110308972
Hypoxia 123.55 12.27 321 97958 129194 110361826
Parainfluenzae virus infection 123.24 12.27 77 98202 6897 110484123
Escherichia bacteraemia 121.40 12.27 88 98191 10076 110480944
Injury 120.07 12.27 10 98269 177255 110313765
Cytomegalovirus infection 119.75 12.27 191 98088 54253 110436767
Enterobacter infection 115.06 12.27 69 98210 5742 110485278
Wheezing 114.16 12.27 42 98237 255188 110235832
Drug interaction 113.43 12.27 168 98111 500015 109991005
Neuropathy peripheral 113.39 12.27 384 97895 178893 110312127
Headache 111.64 12.27 406 97873 881971 109609049
Mobility decreased 111.49 12.27 36 98243 237386 110253634
Discomfort 111.15 12.27 27 98252 214680 110276340
Graft versus host disease 110.28 12.27 108 98171 18698 110472322
Computerised tomogram thorax 107.95 12.27 33 98246 493 110490527
Toxicity to various agents 106.46 12.27 164 98115 480391 110010629
Diarrhoea 106.01 12.27 1507 96772 1137998 109353022
Rhinovirus infection 105.55 12.27 86 98193 11703 110479317
Agranulocytosis 104.67 12.27 193 98086 61567 110429453
Weight increased 104.13 12.27 132 98147 419512 110071508
Cystitis haemorrhagic 100.85 12.27 85 98194 12124 110478896
Depression 100.17 12.27 81 98198 317254 110173766
Rheumatoid factor positive 99.55 12.27 4 98275 131636 110359384
Enteritis 99.47 12.27 103 98176 19053 110471967
Hepatic enzyme increased 98.71 12.27 84 98195 320808 110170212
Bacteraemia 97.78 12.27 152 98127 42238 110448782
Treatment failure 97.63 12.27 63 98216 277171 110213849
Haemophagocytic lymphohistiocytosis 97.48 12.27 130 98149 31429 110459591
Intentional overdose 97.02 12.27 5 98274 132496 110358524
Atelectasis 96.60 12.27 140 98139 36572 110454448
Immune effector cell-associated neurotoxicity syndrome 96.36 12.27 90 98189 14692 110476328
Aspergillus infection 95.70 12.27 116 98163 25500 110465520
Viraemia 95.22 12.27 54 98225 4048 110486972
Somnolence 95.04 12.27 75 98204 297374 110193646
Bursitis 94.82 12.27 5 98274 129913 110361107
Gait disturbance 94.24 12.27 66 98213 278142 110212878
Venoocclusive liver disease 94.19 12.27 90 98189 15117 110475903
White blood cell count abnormal 92.18 12.27 64 98215 6845 110484175
Nasopharyngitis 91.79 12.27 130 98149 394231 110096789
Acute graft versus host disease in skin 91.25 12.27 76 98203 10664 110480356
Osteoarthritis 90.63 12.27 25 98254 182598 110308422
Cellulitis 90.57 12.27 282 97997 125734 110365286
Pericarditis 89.97 12.27 41 98238 219073 110271947
Impaired healing 88.59 12.27 32 98247 196685 110294335
Pleural effusion 88.25 12.27 352 97927 177357 110313663
Joint range of motion decreased 87.95 12.27 5 98274 121827 110369193
Fungal infection 87.65 12.27 160 98119 50646 110440374
Folliculitis 86.93 12.27 21 98258 167632 110323388
Aplasia 86.90 12.27 65 98214 7808 110483212
Tumour lysis syndrome 86.25 12.27 121 98158 30680 110460340
Infusion related reaction 84.46 12.27 130 98149 381032 110109988
Rash maculo-papular 83.50 12.27 196 98083 74026 110416994
Sinusitis 82.60 12.27 85 98194 296603 110194417
Chronic graft versus host disease 82.59 12.27 68 98211 9389 110481631
Overdose 82.49 12.27 53 98226 233741 110257279
Pneumatosis intestinalis 82.28 12.27 65 98214 8464 110482556
Immune reconstitution inflammatory syndrome 82.02 12.27 86 98193 16140 110474880
Blood pressure increased 81.46 12.27 66 98213 258307 110232713
Dizziness 81.28 12.27 332 97947 697861 109793159
Hypersensitivity 79.21 12.27 149 98130 403849 110087171
Capillary leak syndrome 78.78 12.27 51 98228 4857 110486163
Hypertension 78.22 12.27 215 98064 509869 109981151
Herpes simplex 76.93 12.27 82 98197 15682 110475338
Lymphadenopathy 76.69 12.27 173 98106 63662 110427358
Neurotoxicity 75.45 12.27 135 98144 42072 110448948
Skin toxicity 75.39 12.27 71 98208 11712 110479308
Product dose omission issue 73.94 12.27 107 98172 321675 110169345
Clostridium difficile infection 73.80 12.27 151 98128 51978 110439042
Urticaria 73.30 12.27 106 98173 318751 110172269
Colitis 72.61 12.27 228 98051 102095 110388925
Contusion 71.85 12.27 61 98218 233300 110257720
Loss of personal independence in daily activities 71.75 12.27 22 98257 149998 110341022
Psoriasis 71.67 12.27 18 98261 139975 110351045
Condition aggravated 71.54 12.27 373 97906 734463 109756557
Pseudomonas infection 71.51 12.27 105 98174 27748 110463272
Viral infection 70.64 12.27 150 98129 52989 110438031
Peripheral sensory neuropathy 69.71 12.27 80 98199 16600 110474420
Respiratory failure 69.49 12.27 376 97903 214956 110276064
Gait inability 68.92 12.27 18 98261 136358 110354662
Acute respiratory distress syndrome 68.23 12.27 148 98131 53050 110437970
Leukocytosis 68.18 12.27 149 98130 53679 110437341
Cytomegalovirus chorioretinitis 68.07 12.27 54 98225 7074 110483946
Escherichia sepsis 67.84 12.27 63 98216 10209 110480811
Splenic rupture 67.44 12.27 37 98242 2600 110488420
Suicidal ideation 67.36 12.27 4 98275 93933 110397087
Suicide attempt 66.90 12.27 7 98272 103387 110387633
Face oedema 66.28 12.27 112 98167 33357 110457663
Blister 65.74 12.27 63 98216 227313 110263707
Liver injury 65.16 12.27 26 98253 150387 110340633
Memory impairment 65.01 12.27 48 98231 196896 110294124
Enterococcal infection 64.60 12.27 85 98194 20281 110470739
Hypoaesthesia 64.16 12.27 113 98166 314110 110176910
Acute graft versus host disease in intestine 63.23 12.27 47 98232 5592 110485428
Migraine 63.20 12.27 37 98242 171615 110319405
Road traffic accident 62.92 12.27 10 98269 107388 110383632
Neutrophil count abnormal 62.58 12.27 45 98234 5087 110485933
Gastrooesophageal reflux disease 61.85 12.27 42 98237 179934 110311086
Muscle spasms 61.46 12.27 95 98184 278062 110212958
Stem cell transplant 61.40 12.27 42 98237 4385 110486635
Stress 61.29 12.27 10 98269 105338 110385682
Abscess bacterial 60.89 12.27 25 98254 912 110490108
Sciatica 60.45 12.27 6 98273 92393 110398627
Acute febrile neutrophilic dermatosis 59.55 12.27 43 98236 4893 110486127
Splenomegaly 59.53 12.27 90 98189 24408 110466612
Tonsillar disorder 58.79 12.27 28 98251 1461 110489559
Pneumonia fungal 58.71 12.27 69 98210 14685 110476335
Escherichia infection 58.59 12.27 88 98191 23728 110467292
Drug effective for unapproved indication 57.62 12.27 67 98212 14100 110476920
Musculoskeletal pain 57.37 12.27 47 98232 182976 110308044
Pain in extremity 57.02 12.27 231 98048 486887 110004133
Pneumonia klebsiella 56.49 12.27 47 98232 6585 110484435
Prescribed overdose 56.48 12.27 6 98273 87575 110403445
Dry mouth 55.96 12.27 57 98222 199891 110291129
Acute lymphocytic leukaemia recurrent 55.60 12.27 44 98235 5743 110485277
Neutropenic infection 55.26 12.27 35 98244 3210 110487810
Confusional state 55.01 12.27 222 98057 468458 110022562
Intentional product use issue 54.45 12.27 85 98194 247821 110243199
Cytomegalovirus test positive 54.07 12.27 47 98232 6989 110484031
Blood pressure systolic increased 52.72 12.27 6 98273 82985 110408035
Therapeutic product effect incomplete 51.81 12.27 74 98205 223731 110267289
Pruritus 51.20 12.27 305 97974 581255 109909765
Device related infection 50.74 12.27 110 98169 39409 110451611
Systemic candida 50.66 12.27 53 98226 9921 110481099
Inflammation 49.76 12.27 59 98220 193179 110297841
Paronychia 49.46 12.27 55 98224 11026 110479994
Insomnia 49.45 12.27 160 98119 360430 110130590
Cytogenetic abnormality 48.67 12.27 23 98256 1179 110489841
Gene mutation 48.67 12.27 33 98246 3396 110487624
Disseminated intravascular coagulation 48.60 12.27 111 98168 41175 110449845
Blood pressure fluctuation 48.58 12.27 5 98274 74819 110416201
Colitis ulcerative 48.14 12.27 6 98273 77357 110413663
Streptococcal bacteraemia 48.11 12.27 37 98242 4632 110486388
Pulmonary haemorrhage 48.10 12.27 66 98213 16390 110474630
Hypercholesterolaemia 47.83 12.27 11 98268 90826 110400194
Alpha haemolytic streptococcal infection 47.27 12.27 33 98246 3560 110487460
Thrombotic microangiopathy 46.77 12.27 89 98190 29060 110461960
Red blood cell sedimentation rate increased 46.53 12.27 7 98272 78295 110412725
Blood magnesium decreased 46.52 12.27 72 98207 19924 110471096
Pharyngeal inflammation 46.48 12.27 25 98254 1689 110489331
Venoocclusive disease 45.96 12.27 41 98238 6309 110484711
Ill-defined disorder 45.87 12.27 43 98236 156810 110334210
Graft versus host disease in skin 45.80 12.27 46 98233 8208 110482812
Arthritis 45.51 12.27 49 98230 167537 110323483
Exposure during pregnancy 45.41 12.27 49 98230 167375 110323645
Haemoglobin decreased 44.38 12.27 375 97904 248352 110242668
Epistaxis 44.33 12.27 231 98048 130141 110360879
Platelet transfusion 44.28 12.27 29 98250 2817 110488203
Neuroblastoma recurrent 44.13 12.27 17 98262 523 110490497
Cytomegalovirus infection reactivation 44.04 12.27 67 98212 18266 110472754
Candida infection 43.72 12.27 117 98162 47892 110443128
Heart rate abnormal 43.25 12.27 42 98237 7196 110483824
Rash pustular 42.96 12.27 55 98224 12774 110478246
Nasal congestion 42.54 12.27 17 98262 98265 110392755
Live birth 41.78 12.27 6 98273 69478 110421542
Maternal exposure during pregnancy 41.63 12.27 104 98175 254779 110236241
Acute graft versus host disease in liver 41.56 12.27 26 98253 2333 110488687
Product quality issue 41.42 12.27 9 98270 77290 110413730
Myocardial infarction 41.10 12.27 67 98212 192016 110299004
Klebsiella infection 41.01 12.27 68 98211 19941 110471079
Inappropriate schedule of product administration 40.85 12.27 74 98205 203563 110287457
Renal failure 40.10 12.27 341 97938 226233 110264787
Malaise 39.91 12.27 393 97886 671426 109819594
Polyneuropathy 39.84 12.27 88 98191 31924 110459096
Wound infection 39.66 12.27 18 98261 96447 110394573
Therapy partial responder 39.66 12.27 96 98183 36965 110454055
Feeling abnormal 39.64 12.27 62 98217 180649 110310371
Bacillus infection 39.50 12.27 22 98257 1592 110489428
Bradycardia 39.49 12.27 48 98231 155469 110335551
Acute lymphocytic leukaemia 39.32 12.27 36 98243 5729 110485291
Crystal nephropathy 39.26 12.27 23 98256 1833 110489187
Injection site pain 39.07 12.27 61 98218 177861 110313159
Alveolitis 38.94 12.27 32 98247 4407 110486613
Lymphadenitis 38.83 12.27 35 98244 5458 110485562
Muscular weakness 38.58 12.27 104 98175 248364 110242656
Campylobacter gastroenteritis 38.44 12.27 23 98256 1906 110489114
Neutrophil count increased 38.41 12.27 91 98188 34561 110456459
Neoplasm recurrence 38.30 12.27 34 98245 5198 110485822
Serotonin syndrome 38.28 12.27 4 98275 59149 110431871
Intentional product misuse 38.20 12.27 37 98242 132867 110358153
Injection site swelling 37.94 12.27 5 98274 61785 110429235
Osteoporosis 37.85 12.27 15 98264 87137 110403883
Injection site reaction 37.59 12.27 16 98263 89054 110401966
Pneumonitis 37.48 12.27 151 98128 76380 110414640
Abdominal pain upper 37.48 12.27 171 98108 348940 110142080
Drug-induced liver injury 37.41 12.27 31 98248 120036 110370984
Alopecia 37.20 12.27 182 98097 364571 110126449
Staphylococcal infection 36.68 12.27 141 98138 69803 110421217
Hypophosphataemia 36.63 12.27 87 98192 33095 110457925
Night sweats 36.57 12.27 39 98240 133944 110357076
Heart rate decreased 36.34 12.27 14 98265 82742 110408278
Leukaemoid reaction 36.06 12.27 14 98265 440 110490580
BK virus infection 35.97 12.27 51 98228 13055 110477965
Medication error 35.65 12.27 25 98254 105341 110385679
Sedation 35.58 12.27 9 98270 69674 110421346
Chills 35.41 12.27 290 97989 190290 110300730
Streptococcal sepsis 35.23 12.27 32 98247 5040 110485980
Pseudomonal bacteraemia 35.21 12.27 30 98249 4341 110486679
Tremor 35.02 12.27 80 98199 202152 110288868
White blood cell count increased 34.60 12.27 174 98105 96668 110394352
Blood lactate dehydrogenase increased 34.45 12.27 102 98177 44232 110446788
Klebsiella bacteraemia 34.37 12.27 31 98248 4838 110486182
Hypogammaglobulinaemia 34.33 12.27 63 98216 20013 110471007
Blood culture positive 34.10 12.27 41 98238 8935 110482085
Oral herpes 33.94 12.27 89 98190 35991 110455029
Excessive eye blinking 33.93 12.27 21 98258 1849 110489171
Streptococcal infection 33.84 12.27 45 98234 10845 110480175
Injection site erythema 33.68 12.27 21 98258 94155 110396865
Adenovirus infection 33.51 12.27 45 98234 10949 110480071
Oesophageal candidiasis 33.32 12.27 46 98233 11488 110479532
Incorrect dose administered 33.24 12.27 26 98253 103615 110387405
Diffuse alveolar damage 33.06 12.27 28 98251 4019 110487001
Balance disorder 32.86 12.27 33 98246 116527 110374493
Leukaemia recurrent 32.67 12.27 25 98254 3106 110487914
Foot deformity 32.10 12.27 3 98276 48477 110442543
Corynebacterium sepsis 31.89 12.27 11 98268 245 110490775
Candida test positive 31.89 12.27 18 98261 1337 110489683
Amnesia 31.88 12.27 28 98251 105380 110385640
Intracardiac thrombus 31.77 12.27 28 98251 4240 110486780
Neutrophilic dermatosis 31.59 12.27 15 98264 777 110490243
Plasma cell myeloma recurrent 31.51 12.27 35 98244 7007 110484013
Staphylococcal sepsis 31.41 12.27 56 98223 17398 110473622
COVID-19 pneumonia 31.31 12.27 88 98191 37055 110453965
Toxic epidermal necrolysis 31.10 12.27 116 98163 56611 110434409
Pneumocystis jirovecii pneumonia 31.02 12.27 96 98183 42639 110448381
Viral haemorrhagic cystitis 30.86 12.27 25 98254 3374 110487646
Engraftment syndrome 30.82 12.27 20 98259 1912 110489108
Rhabdomyolysis 30.73 12.27 37 98242 120364 110370656
Onycholysis 30.65 12.27 23 98256 2776 110488244
Nail disorder 30.53 12.27 7 98272 57928 110433092
Plasma cells increased 30.32 12.27 9 98270 121 110490899
Hemianopia 30.15 12.27 23 98256 2845 110488175
Nasal disorder 29.97 12.27 27 98252 4207 110486813
Diffuse large B-cell lymphoma 29.90 12.27 52 98227 15846 110475174
Frequent bowel movements 29.85 12.27 13 98266 71377 110419643
Bone marrow necrosis 29.72 12.27 12 98267 419 110490601
Blood stem cell harvest failure 29.66 12.27 9 98270 131 110490889
Adverse drug reaction 29.63 12.27 30 98249 105529 110385491
Hypomagnesaemia 29.47 12.27 119 98160 60251 110430769
Transfusion 29.44 12.27 68 98211 25404 110465616
Cutaneous T-cell lymphoma stage I 28.99 12.27 9 98270 142 110490878
Malignant neoplasm progression 28.94 12.27 259 98020 174308 110316712
Deep vein thrombosis 28.81 12.27 218 98061 139669 110351351
Back injury 28.71 12.27 4 98275 47395 110443625
Palmar-plantar erythrodysaesthesia syndrome 28.71 12.27 91 98188 40934 110450086
Prescribed underdose 28.66 12.27 11 98268 65163 110425857
Myelosuppression 28.58 12.27 162 98117 94178 110396842
Fungaemia 28.54 12.27 31 98248 6055 110484965
Clostridium bacteraemia 28.04 12.27 12 98267 486 110490534
Bacterial sepsis 27.77 12.27 40 98239 10386 110480634
Visceral leishmaniasis 27.58 12.27 18 98261 1738 110489282
Chronic lymphocytic leukaemia 27.29 12.27 30 98249 5938 110485082
Marrow hyperplasia 27.21 12.27 18 98261 1778 110489242
Femoroacetabular impingement 26.94 12.27 6 98273 22 110490998
Varicose vein 26.86 12.27 32 98247 6908 110484112
Chemotherapy 26.59 12.27 19 98260 2127 110488893
Lactic acidosis 26.48 12.27 26 98253 92785 110398235
Interstitial lung disease 26.40 12.27 213 98066 139121 110351899
Chronic obstructive pulmonary disease 26.35 12.27 35 98244 109123 110381897
Oesophagitis 26.17 12.27 70 98209 28645 110462375
Coronavirus infection 25.98 12.27 37 98242 9508 110481512
Cerebrovascular accident 25.84 12.27 79 98200 181205 110309815
Lupus-like syndrome 25.78 12.27 3 98276 40789 110450231
Bone erosion 25.67 12.27 5 98274 46366 110444654
Cognitive disorder 25.57 12.27 24 98255 87487 110403533
Feeling hot 25.45 12.27 26 98253 91080 110399940
Dyspnoea 25.33 12.27 770 97509 1106102 109384918
Transplant failure 25.21 12.27 28 98251 5607 110485413
Joint injury 25.13 12.27 3 98276 39991 110451029
Extramedullary haemopoiesis 25.10 12.27 10 98269 337 110490683
Chronic lymphocytic leukaemia recurrent 24.86 12.27 14 98265 1035 110489985
Pneumonia moraxella 24.73 12.27 8 98271 145 110490875
Gamma-glutamyltransferase increased 24.67 12.27 114 98165 61195 110429825
Agitation 24.58 12.27 39 98240 113012 110378008
Rash scarlatiniform 24.53 12.27 10 98269 358 110490662
Petechiae 24.52 12.27 60 98219 23257 110467763
Diabetic ketoacidosis 24.44 12.27 4 98275 42054 110448966
Large granular lymphocytosis 24.25 12.27 11 98268 513 110490507
Metastases to lymph nodes 24.24 12.27 46 98233 14986 110476034
Radiation fibrosis - lung 24.23 12.27 7 98272 85 110490935
Cerebellar stroke 24.16 12.27 13 98266 879 110490141
Atrial fibrillation 24.16 12.27 311 97968 229331 110261689
Epididymitis 24.11 12.27 19 98260 2465 110488555
Joint stiffness 24.03 12.27 15 98264 67228 110423792
Enterobacter sepsis 24.03 12.27 15 98264 1341 110489679
Myeloid leukaemia 23.98 12.27 13 98266 892 110490128
Bladder hypertrophy 23.96 12.27 14 98265 1110 110489910
Ultrasound foetal abnormal 23.87 12.27 7 98272 90 110490930
Diabetes mellitus 23.85 12.27 32 98247 99349 110391671
Blood disorder 23.77 12.27 36 98243 9774 110481246
Neoplasm progression 23.73 12.27 117 98162 64478 110426542
Hepatosplenomegaly 23.70 12.27 30 98249 6889 110484131
Swollen tongue 23.68 12.27 12 98267 60350 110430670
Gastroenteritis norovirus 23.56 12.27 22 98257 3589 110487431
Drug withdrawal syndrome 23.56 12.27 3 98276 38051 110452969
Dysarthria 23.50 12.27 24 98255 84097 110406923
Toxic erythema of chemotherapy 23.44 12.27 10 98269 402 110490618
Pulmonary fibrosis 23.35 12.27 34 98245 102008 110389012
Graft versus host disease in gastrointestinal tract 23.30 12.27 34 98245 8934 110482086
Venous thrombosis 23.20 12.27 33 98246 8472 110482548
Progressive multifocal leukoencephalopathy 22.90 12.27 61 98218 24895 110466125
Paraesthesia 22.74 12.27 148 98131 276373 110214647
Infection 22.74 12.27 450 97829 361750 110129270
Visual impairment 22.61 12.27 54 98225 134374 110356646
Sinusitis fungal 22.59 12.27 19 98260 2701 110488319
Urinary bladder haematoma 22.52 12.27 5 98274 18 110491002
Vascular device infection 22.39 12.27 47 98232 16465 110474555
White blood cell disorder 22.32 12.27 22 98257 3837 110487183
Haematochezia 22.26 12.27 43 98236 115481 110375539
Bone marrow transplant rejection 22.14 12.27 9 98270 320 110490700
Biliary sepsis 22.11 12.27 16 98263 1827 110489193
Cholangitis infective 22.09 12.27 12 98267 827 110490193
Nephrolithiasis 22.02 12.27 16 98263 66196 110424824
Splenic haematoma 21.93 12.27 9 98270 328 110490692
Subclavian vein thrombosis 21.93 12.27 19 98260 2813 110488207
International normalised ratio increased 21.79 12.27 27 98252 86745 110404275
Leukaemia 21.74 12.27 30 98249 7488 110483532
Onychomycosis 21.66 12.27 4 98275 38527 110452493
Mucosal disorder 21.59 12.27 23 98256 4394 110486626
Procedural pain 21.55 12.27 3 98276 35562 110455458
Peripheral T-cell lymphoma unspecified 21.41 12.27 12 98267 879 110490141
Lung infiltration 21.40 12.27 59 98220 24569 110466451
Extravasation blood 21.34 12.27 10 98269 503 110490517
Enterococcal sepsis 21.27 12.27 20 98259 3292 110487728
Bone marrow transplant 21.27 12.27 15 98264 1645 110489375
Candida sepsis 21.19 12.27 19 98260 2942 110488078
Bacterial diarrhoea 21.12 12.27 9 98270 361 110490659
Fluid retention 21.01 12.27 32 98247 94275 110396745
Hypogonadism 20.98 12.27 16 98263 1978 110489042
Klebsiella sepsis 20.97 12.27 22 98257 4131 110486889
Coma 20.91 12.27 46 98233 117823 110373197
Product use issue 20.78 12.27 177 98102 311518 110179502
Bone marrow disorder 20.66 12.27 22 98257 4201 110486819
Constipation 20.65 12.27 439 97840 357347 110133673
Pneumonia cytomegaloviral 20.49 12.27 28 98251 6926 110484094
Joint dislocation 20.44 12.27 3 98276 34187 110456833
Hepatic cirrhosis 20.41 12.27 18 98261 67608 110423412
Fluid intake reduced 20.39 12.27 28 98251 6958 110484062
Pulmonary sarcoidosis 20.39 12.27 15 98264 1757 110489263
Cytokine storm 20.34 12.27 14 98265 1476 110489544
Neuroleptic malignant syndrome 20.34 12.27 3 98276 34056 110456964
Pregnancy 20.26 12.27 10 98269 51057 110439963
Alanine aminotransferase increased 20.23 12.27 251 98028 183522 110307498
Blood bilirubin increased 20.15 12.27 126 98153 75846 110415174
Oral candidiasis 20.10 12.27 86 98193 44674 110446346
Brain oedema 19.98 12.27 67 98212 31031 110459989
Aspergilloma 19.85 12.27 11 98268 788 110490232
Delirium 19.85 12.27 58 98221 134967 110356053
Meningitis tuberculous 19.83 12.27 13 98266 1265 110489755
Multiple sclerosis relapse 19.69 12.27 10 98269 50230 110440790
Cataract 19.68 12.27 25 98254 79460 110411560
Blood pressure diastolic decreased 19.59 12.27 4 98275 35881 110455139
Platelet count abnormal 19.58 12.27 26 98253 6256 110484764
Engraft failure 19.51 12.27 11 98268 815 110490205
Vulvovaginal candidiasis 19.51 12.27 19 98260 3266 110487754
Myoclonus 19.49 12.27 3 98276 32995 110458025
Abdominal wall wound 19.48 12.27 6 98273 92 110490928
Coronary artery disease 19.41 12.27 21 98258 71669 110419351
Lymphocytosis 19.39 12.27 24 98255 5387 110485633
Chest discomfort 19.34 12.27 84 98195 173764 110317256
Sinus disorder 19.27 12.27 3 98276 32725 110458295
Pseudomembranous colitis 19.23 12.27 26 98253 6365 110484655
Illness 19.17 12.27 27 98252 82144 110408876
Treatment noncompliance 19.09 12.27 22 98257 72968 110418052
Periumbilical abscess 19.03 12.27 8 98271 310 110490710
Osteolysis 19.00 12.27 24 98255 5499 110485521
Myeloblast percentage decreased 18.97 12.27 5 98274 42 110490978
Follicular lymphoma stage IV 18.76 12.27 5 98274 44 110490976
Hyperbilirubinaemia 18.75 12.27 65 98214 30606 110460414
Pneumonia pseudomonal 18.73 12.27 28 98251 7518 110483502
Device related thrombosis 18.67 12.27 19 98260 3443 110487577
Nail bed inflammation 18.58 12.27 15 98264 2015 110489005
Inadequate osteointegration 18.57 12.27 4 98275 12 110491008
Fibrosis 18.46 12.27 28 98251 7614 110483406
Cardiac ventricular thrombosis 18.31 12.27 18 98261 3129 110487891
Fusarium infection 18.31 12.27 17 98262 2754 110488266
Cystitis viral 18.15 12.27 13 98266 1460 110489560
Sopor 18.13 12.27 5 98274 36541 110454479
Hyperkalaemia 18.08 12.27 61 98218 135735 110355285
Folate deficiency 18.06 12.27 21 98258 4417 110486603
Dry eye 17.89 12.27 14 98265 55779 110435241
Injection site bruising 17.55 12.27 12 98267 51251 110439769
Stomatococcal infection 17.50 12.27 8 98271 380 110490640
Sinus congestion 17.47 12.27 3 98276 30456 110460564
Hydronephrosis 17.46 12.27 49 98230 20616 110470404
Nasal mucosal disorder 17.41 12.27 14 98265 1869 110489151
Urinary tract infection pseudomonal 17.39 12.27 15 98264 2207 110488813
Blood glucose increased 17.31 12.27 60 98219 132436 110358584
Laryngitis 17.30 12.27 8 98271 42403 110448617
Disability 17.29 12.27 3 98276 30220 110460800
Red blood cell count decreased 17.27 12.27 109 98170 65814 110425206
Acanthosis 17.23 12.27 9 98270 573 110490447
Eye pruritus 17.19 12.27 4 98275 32771 110458249
Full blood count decreased 17.07 12.27 65 98214 32034 110458986
Acute respiratory failure 17.04 12.27 120 98159 75140 110415880
Liver function test increased 17.02 12.27 33 98246 88515 110402505
Hypoglycaemia 16.97 12.27 50 98229 116054 110374966
Tonsillitis 16.95 12.27 28 98251 8185 110482835
Product storage error 16.89 12.27 50 98229 21678 110469342
Cytomegalovirus enteritis 16.81 12.27 11 98268 1067 110489953
PSTPIP1-associated myeloid-related proteinaemia inflammatory syndrome 16.80 12.27 4 98275 21 110490999
Eye pain 16.80 12.27 12 98267 50087 110440933
Taste disorder 16.78 12.27 20 98259 65367 110425653
Therapeutic response shortened 16.78 12.27 3 98276 29580 110461440
Ocular hyperaemia 16.67 12.27 7 98272 39279 110451741
Herpes simplex encephalitis 16.64 12.27 10 98269 835 110490185
Accidental overdose 16.62 12.27 13 98266 51821 110439199
Abnormal behaviour 16.49 12.27 7 98272 39032 110451988
Hypocalcaemia 16.46 12.27 107 98172 65259 110425761
Cardiac failure 16.44 12.27 246 98033 187380 110303640
Systemic inflammatory response syndrome 16.39 12.27 36 98243 13007 110478013
Device dislocation 16.37 12.27 4 98275 31700 110459320
Escherichia test positive 16.36 12.27 18 98261 3566 110487454
Biliary tract infection 16.33 12.27 13 98266 1711 110489309
Delayed engraftment 16.32 12.27 7 98272 285 110490735
Ear infection 16.30 12.27 19 98260 62713 110428307
Intestinal fistula 16.27 12.27 13 98266 1720 110489300
Movement disorder 16.25 12.27 6 98273 36398 110454622
Laryngeal cancer stage IV 16.21 12.27 4 98275 25 110490995
Cardio-respiratory arrest 16.14 12.27 51 98228 115785 110375235
Out of specification test results 16.07 12.27 6 98273 169 110490851
Depressed level of consciousness 15.95 12.27 49 98230 112229 110378791
Cardiac disorder 15.94 12.27 27 98252 76253 110414767
Herpes simplex reactivation 15.93 12.27 12 98267 1456 110489564
Lip swelling 15.88 12.27 13 98266 50654 110440366
Disturbance in attention 15.87 12.27 19 98260 61976 110429044
Eye irritation 15.82 12.27 5 98274 33447 110457573
Infective aortitis 15.81 12.27 5 98274 84 110490936
Adverse event 15.80 12.27 47 98232 108762 110382258
Enterococcus test positive 15.77 12.27 16 98263 2888 110488132
Raoultella ornithinolytica infection 15.75 12.27 6 98273 179 110490841
Amniotic fluid volume decreased 15.67 12.27 7 98272 315 110490705
Speech disorder 15.63 12.27 19 98260 61550 110429470
Neutrophil/lymphocyte ratio increased 15.54 12.27 3 98276 4 110491016
Spermatozoa morphology abnormal 15.54 12.27 3 98276 4 110491016
Transformation to acute myeloid leukaemia 15.54 12.27 12 98267 1511 110489509
Blood stem cell transplant failure 15.46 12.27 9 98270 709 110490311
Anaphylactic reaction 15.45 12.27 51 98228 114249 110376771
Growth of eyelashes 15.38 12.27 6 98273 191 110490829
Intentional self-injury 15.36 12.27 7 98272 37422 110453598
Aspartate aminotransferase increased 15.32 12.27 213 98066 159723 110331297
Pulmonary resection 15.29 12.27 6 98273 194 110490826
Therapeutic response decreased 15.26 12.27 40 98239 96459 110394561
Lymph node pain 15.21 12.27 13 98266 1889 110489131
Enterocolitis infectious 15.21 12.27 17 98262 3427 110487593
Purpura 15.19 12.27 52 98227 24336 110466684
Central nervous system lymphoma 15.15 12.27 16 98263 3028 110487992
Anaemia of malignant disease 15.13 12.27 10 98269 986 110490034
Colorectal cancer metastatic 15.09 12.27 12 98267 1577 110489443
Encephalitis brain stem 15.07 12.27 7 98272 345 110490675
Staphylococcus test positive 15.04 12.27 25 98254 7345 110483675
Angina pectoris 15.00 12.27 20 98259 62275 110428745
Ejection fraction decreased 14.98 12.27 74 98205 40806 110450214
Trichosporon infection 14.95 12.27 11 98268 1289 110489731
Acute kidney injury 14.93 12.27 699 97580 634731 109856289
Plasmablast count increased 14.93 12.27 4 98275 36 110490984
Monocytopenia 14.90 12.27 6 98273 208 110490812
Nightmare 14.84 12.27 8 98271 38855 110452165
Syphilis 14.83 12.27 9 98270 765 110490255
Dyspepsia 14.80 12.27 104 98175 190861 110300159
Febrile infection 14.78 12.27 19 98260 4429 110486591
Skin maceration 14.77 12.27 6 98273 213 110490807
Ecthyma 14.75 12.27 10 98269 1029 110489991
Abdominal mass 14.72 12.27 20 98259 4921 110486099
Tissue infiltration 14.71 12.27 10 98269 1033 110489987
Underdose 14.71 12.27 21 98258 63533 110427487
Emotional distress 14.70 12.27 11 98268 44836 110446184
Hyperpyrexia 14.66 12.27 26 98253 8043 110482977
Skin oedema 14.65 12.27 13 98266 1986 110489034
Generalised oedema 14.57 12.27 60 98219 30644 110460376
Bronchitis 14.51 12.27 81 98198 156951 110334069
Anal abscess 14.49 12.27 32 98247 11606 110479414
Peripheral motor neuropathy 14.45 12.27 18 98261 4068 110486952
Metastases to liver 14.38 12.27 66 98213 35320 110455700
Lymphoma 14.35 12.27 45 98234 20126 110470894
Ovarian disorder 14.33 12.27 8 98271 582 110490438
Tumour necrosis 14.30 12.27 14 98265 2422 110488598
Hallucination, auditory 14.29 12.27 3 98276 26394 110464626
Chronic myeloid leukaemia recurrent 14.27 12.27 7 98272 390 110490630
Neutrophil Pelger-Huet anomaly present 14.27 12.27 7 98272 390 110490630
B-cell lymphoma 14.24 12.27 24 98255 7130 110483890
Autoimmune haemolytic anaemia 14.24 12.27 30 98249 10537 110480483
Naevus haemorrhage 14.15 12.27 5 98274 120 110490900
Necrotising colitis 13.99 12.27 12 98267 1753 110489267
Rectosigmoid cancer metastatic 13.81 12.27 4 98275 49 110490971
Hyperthermia 13.81 12.27 46 98233 21226 110469794
Systemic mycosis 13.75 12.27 17 98262 3812 110487208
Hyperchlorhydria 13.74 12.27 13 98266 2156 110488864
Dermatitis atopic 13.63 12.27 3 98276 25538 110465482
Coagulopathy 13.56 12.27 72 98207 40839 110450181
Neutrophilia 13.54 12.27 29 98250 10300 110480720
Angiodysplasia 13.54 12.27 11 98268 1491 110489529
Cytomegalovirus hepatitis 13.53 12.27 9 98270 897 110490123
Pulmonary arterial hypertension 13.50 12.27 6 98273 32562 110458458
Respiratory tract infection viral 13.44 12.27 21 98258 5857 110485163
Thrombocytopenic purpura 13.42 12.27 15 98264 3024 110487996
Neck pain 13.38 12.27 60 98219 123070 110367950
Epilepsy 13.35 12.27 45 98234 100164 110390856
Proctitis bacterial 13.32 12.27 5 98274 143 110490877
Symmetrical drug-related intertriginous and flexural exanthema 13.24 12.27 12 98267 1885 110489135
Enterocolitis 13.23 12.27 42 98237 18907 110472113
Oesophageal haemorrhage 13.21 12.27 12 98267 1891 110489129
Hallucination 13.21 12.27 46 98233 101386 110389634
Relapsing fever 13.18 12.27 7 98272 461 110490559
Gastrointestinal toxicity 13.15 12.27 30 98249 11118 110479902
Burning sensation 13.13 12.27 26 98253 69186 110421834
Minimal residual disease 13.12 12.27 9 98270 944 110490076
Acute myeloid leukaemia refractory 13.10 12.27 6 98273 286 110490734
Breast cancer metastatic 13.09 12.27 30 98249 11151 110479869
Obstructive airways disorder 13.08 12.27 13 98266 46136 110444884
Skin haemorrhage 13.08 12.27 3 98276 24824 110466196
Ascites 13.04 12.27 133 98146 92675 110398345
Granulomatous liver disease 13.02 12.27 11 98268 1573 110489447
Serum ferritin increased 13.01 12.27 31 98248 11816 110479204
Ileus 13.00 12.27 58 98221 30671 110460349
Erysipelas 12.93 12.27 33 98246 13125 110477895
Dyskinesia 12.93 12.27 16 98263 51430 110439590
Erythropenia 12.92 12.27 7 98272 480 110490540
Post procedural diarrhoea 12.88 12.27 7 98272 483 110490537
Heart rate increased 12.85 12.27 75 98204 143759 110347261
Uterine enlargement 12.85 12.27 9 98270 976 110490044
Electrolyte imbalance 12.85 12.27 66 98213 36962 110454058
Pseudomonas test positive 12.84 12.27 13 98266 2341 110488679
Labelled drug-drug interaction medication error 12.79 12.27 5 98274 29297 110461723
Guillain-Barre syndrome 12.77 12.27 29 98250 10715 110480305
Pure white cell aplasia 12.76 12.27 5 98274 161 110490859
Motor dysfunction 12.76 12.27 3 98276 24403 110466617
Intensive care 12.73 12.27 13 98266 2366 110488654
Pneumovirus test positive 12.66 12.27 4 98275 67 110490953
Atypical pneumonia 12.61 12.27 24 98255 7838 110483182
Epstein-Barr virus infection 12.60 12.27 41 98238 18697 110472323
Gastric disorder 12.54 12.27 7 98272 33350 110457670
Hyperglycaemia 12.47 12.27 123 98156 84967 110406053
Periodontitis 12.46 12.27 19 98260 5189 110485831
Toxic skin eruption 12.46 12.27 53 98226 27462 110463558
Klebsiella test positive 12.43 12.27 13 98266 2433 110488587
Dermatitis exfoliative generalised 12.36 12.27 29 98250 10943 110480077
Choriocarcinoma 12.34 12.27 4 98275 73 110490947
Therapeutic response unexpected 12.33 12.27 3 98276 23840 110467180

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AA02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Colony stimulating factors
FDA CS M0024696 Granulocyte Colony-Stimulating Factor
FDA PE N0000009451 Increased Myeloid Cell Production
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175666 Leukocyte Growth Factor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

L03AA Colony stimulating factors 6 drugs
efbemalenograstim alfaeflapegrastimlenograstimlipegfilgrastimpegfilgrastimsargramostim

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Congenital neutropenia indication 89655007
Cyclical neutropenia indication 191347008 DOID:5339
Chronic idiopathic neutropenia indication 248693006
Chemotherapy-induced neutropenia indication 425229001
Relapsed acute myeloid leukemia indication 12281000132104
Refractory acute myeloid leukemia indication 12291000132102
Enhancement of an antitumor effect of dinutuximab for neuroblastoma indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Granulocyte colony-stimulating factor receptor Membrane receptor ACTIVATOR DRUG LABEL DRUG LABEL

External reference:

IDSource
PVI5M0M1GW UNII
D03235 KEGG_DRUG
4019570 VUID
N0000147669 NUI
4019570 VANDF
4034460 VANDF
C0210630 UMLSCUI
CHEBI:749461 CHEBI
CHEMBL1201567 ChEMBL_ID
DB00099 DRUGBANK_ID
D000069585 MESH_DESCRIPTOR_UI
6739 INN_ID
6968 IUPHAR_LIGAND_ID
1605064 RXNORM
2266 MMSL
234064 MMSL
33394 MMSL
4727 MMSL
d00512 MMSL
003574 NDDF
015943 NDDF
108965009 SNOMEDCT_US
386948008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nivestym HUMAN PRESCRIPTION DRUG LABEL 1 0069-0291 INJECTION, SOLUTION 300 ug SUBCUTANEOUS BLA 29 sections
Nivestym HUMAN PRESCRIPTION DRUG LABEL 1 0069-0292 INJECTION, SOLUTION 480 ug SUBCUTANEOUS BLA 29 sections
Nivestym HUMAN PRESCRIPTION DRUG LABEL 1 0069-0293 INJECTION, SOLUTION 300 ug SUBCUTANEOUS BLA 29 sections
Nivestym HUMAN PRESCRIPTION DRUG LABEL 1 0069-0294 INJECTION, SOLUTION 480 ug SUBCUTANEOUS BLA 29 sections
Neupogen HUMAN PRESCRIPTION DRUG LABEL 1 54868-2522 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 14 sections
Neupogen HUMAN PRESCRIPTION DRUG LABEL 1 54868-3050 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 14 sections
Neupogen HUMAN PRESCRIPTION DRUG LABEL 1 54868-5020 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 14 sections
NEUPOGEN HUMAN PRESCRIPTION DRUG LABEL 1 55513-209 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 29 sections
NEUPOGEN HUMAN PRESCRIPTION DRUG LABEL 1 55513-530 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 29 sections
NEUPOGEN HUMAN PRESCRIPTION DRUG LABEL 1 55513-546 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 29 sections
NEUPOGEN HUMAN PRESCRIPTION DRUG LABEL 1 55513-924 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 29 sections
ZARXIO HUMAN PRESCRIPTION DRUG LABEL 1 61314-318 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 26 sections
ZARXIO HUMAN PRESCRIPTION DRUG LABEL 1 61314-318 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 26 sections
ZARXIO HUMAN PRESCRIPTION DRUG LABEL 1 61314-326 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 26 sections
ZARXIO HUMAN PRESCRIPTION DRUG LABEL 1 61314-326 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 26 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-910 INJECTION, SOLUTION 300 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-910 INJECTION, SOLUTION 300 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-912 INJECTION, SOLUTION 480 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-912 INJECTION, SOLUTION 480 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-918 INJECTION, SOLUTION 300 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-918 INJECTION, SOLUTION 300 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-920 INJECTION, SOLUTION 480 ug SUBCUTANEOUS BLA 29 sections
GRANIX HUMAN PRESCRIPTION DRUG LABEL 1 63459-920 INJECTION, SOLUTION 480 ug SUBCUTANEOUS BLA 29 sections
NYPOZI HUMAN PRESCRIPTION DRUG LABEL 1 69097-429 INJECTION 480 ug SUBCUTANEOUS BLA 27 sections
NYPOZI HUMAN PRESCRIPTION DRUG LABEL 1 69097-430 INJECTION 300 ug SUBCUTANEOUS BLA 27 sections
FILKRI HUMAN PRESCRIPTION DRUG LABEL 1 69448-008 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 29 sections
FILKRI HUMAN PRESCRIPTION DRUG LABEL 1 69448-009 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 29 sections
RELEUKO HUMAN PRESCRIPTION DRUG LABEL 1 70121-1568 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 28 sections
RELEUKO HUMAN PRESCRIPTION DRUG LABEL 1 70121-1569 INJECTION, SOLUTION 300 ug INTRAVENOUS BLA 28 sections
RELEUKO HUMAN PRESCRIPTION DRUG LABEL 1 70121-1570 INJECTION, SOLUTION 480 ug INTRAVENOUS BLA 28 sections