pegfilgrastim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
granulocyte colony stimulating factor (G-CSF) type substances 4986 208265-92-3

Description:

MoleculeDescription

Synonyms:

  • pegfilgrastim-jmdb
  • fulphila
  • pegfilgrastim
  • neulasta
  • ristempa
  • pegfilgrastim (genetical recombination)
  • g-lasta
pegylated (r-G-CSF) conjugated to polyethylene glycol for treatment of neutropenic patients with non-myeloid malignancies who are at high risk for infection
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.30 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 31, 2002 FDA AMGEN
Aug. 22, 2002 EMA Amgen Europe B.V.
Sept. 26, 2014 PMDA Kyowa Hakko Kirin Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device adhesion issue 35418.92 19.35 6133 91906 558 90529850
Unintentional medical device removal 29761.87 19.35 5332 92707 1698 90528710
Wrong technique in product usage process 16580.32 19.35 5127 92912 66444 90463964
Device use error 15085.89 19.35 3030 95009 4191 90526217
Device malfunction 13829.99 19.35 3423 94616 17554 90512854
Accidental exposure to product 8589.00 19.35 2749 95290 39617 90490791
Device issue 7602.78 19.35 2302 95737 27235 90503173
Device occlusion 6745.86 19.35 1641 96398 7641 90522767
Application site haemorrhage 3975.41 19.35 739 97300 426 90529982
Intercepted product preparation error 3516.57 19.35 680 97359 640 90529768
Drug dose omission by device 3506.27 19.35 997 97042 9234 90521174
Device physical property issue 2996.35 19.35 677 97362 2099 90528309
Occupational exposure to product 2595.28 19.35 592 97447 1939 90528469
Application site pain 2526.93 19.35 654 97385 4066 90526342
Device leakage 2498.77 19.35 763 97276 9228 90521180
Febrile neutropenia 2419.50 19.35 1715 96324 156634 90373774
Bone pain 2044.27 19.35 1098 96941 60885 90469523
Device electrical finding 1184.92 19.35 208 97831 30 90530378
Neutropenia 1176.87 19.35 1329 96710 223575 90306833
Application site discomfort 1131.64 19.35 220 97819 218 90530190
Device power source issue 1120.61 19.35 245 97794 619 90529789
Application site bruise 884.50 19.35 174 97865 194 90530214
Device failure 761.05 19.35 285 97754 6612 90523796
Underdose 756.30 19.35 556 97483 53461 90476947
Investigation 738.01 19.35 197 97842 1400 90529008
Product dose omission issue 722.51 19.35 1200 96839 290487 90239921
Incorrect disposal of product 654.25 19.35 162 97877 816 90529592
Incorrect dose administered by device 625.48 19.35 235 97804 5502 90524906
Product preparation error 543.14 19.35 251 97788 10010 90520398
Drug ineffective 516.99 19.35 446 97593 1383852 89146556
Aortitis 459.59 19.35 131 97908 1219 90529189
Intercepted product administration error 420.75 19.35 112 97927 786 90529622
Neutrophil count decreased 397.57 19.35 437 97602 71095 90459313
Neutrophil count abnormal 381.71 19.35 150 97889 3978 90526430
Arthropathy 379.33 19.35 3 98036 366239 90164169
Joint swelling 376.32 19.35 50 97989 503250 90027158
Drug intolerance 358.27 19.35 35 98004 447556 90082852
Circumstance or information capable of leading to medication error 354.86 19.35 150 97889 4817 90525591
Device delivery system issue 353.35 19.35 114 97925 1664 90528744
Rheumatoid arthritis 339.16 19.35 12 98027 362602 90167806
Condition aggravated 327.37 19.35 118 97921 595427 89934981
Maternal exposure during pregnancy 326.37 19.35 15 98024 360048 90170360
Chemotherapy 318.14 19.35 106 97933 1721 90528687
Needle issue 306.71 19.35 190 97849 13744 90516664
White blood cell count decreased 297.88 19.35 597 97442 166512 90363896
White blood cell count abnormal 295.71 19.35 150 97889 7354 90523054
Hand deformity 291.23 19.35 6 98033 296356 90234052
Abdominal discomfort 288.15 19.35 80 97959 477248 90053160
Treatment failure 287.92 19.35 9 98030 303919 90226489
Product communication issue 285.12 19.35 93 97946 1408 90529000
Hepatic enzyme increased 283.93 19.35 30 98009 360706 90169702
Magnetic resonance imaging 276.09 19.35 56 97983 82 90530326
Pericarditis 275.93 19.35 3 98036 270148 90260260
Weight increased 275.79 19.35 58 97981 417869 90112539
Drug hypersensitivity 263.00 19.35 87 97952 463522 90066886
Infusion related reaction 254.98 19.35 68 97971 416712 90113696
Glossodynia 250.05 19.35 28 98011 321751 90208657
Swelling 247.76 19.35 73 97966 418985 90111423
Product use issue 243.49 19.35 34 98005 329885 90200523
Sinusitis 236.01 19.35 43 97996 343045 90187363
Hypertension 234.22 19.35 101 97938 457431 90072977
Helicobacter infection 229.49 19.35 3 98036 226847 90303561
Musculoskeletal stiffness 224.94 19.35 28 98011 296504 90233904
Therapeutic product effect decreased 223.80 19.35 21 98018 277550 90252858
Wound 221.75 19.35 32 98007 302948 90227460
Peripheral swelling 221.49 19.35 85 97954 413021 90117387
Device placement issue 220.70 19.35 83 97956 1947 90528461
Nasopharyngitis 219.53 19.35 83 97956 407021 90123387
Exposure during pregnancy 219.02 19.35 9 98030 238401 90292007
Hyperhidrosis 215.89 19.35 464 97575 135841 90394567
Death 206.37 19.35 1008 97031 455543 90074865
Off label use 204.51 19.35 1950 96089 1100302 89430106
Folliculitis 201.26 19.35 4 98035 204349 90326059
Fibromyalgia 199.39 19.35 5 98034 206264 90324144
Drug delivery system malfunction 196.97 19.35 69 97970 1312 90529096
Pyrexia 196.19 19.35 1303 96736 659182 89871226
Asthma 183.30 19.35 23 98016 242137 90288271
Type 2 diabetes mellitus 182.33 19.35 9 98030 203235 90327173
Depression 181.95 19.35 50 97989 300551 90229857
Application site erythema 181.89 19.35 96 97943 5112 90525296
Colony stimulating factor therapy 180.36 19.35 49 97990 375 90530033
Impaired healing 180.33 19.35 21 98018 234178 90296230
Pruritus 179.31 19.35 193 97846 541332 89989076
Osteoarthritis 177.74 19.35 8 98031 195722 90334686
Intentional product use issue 175.91 19.35 16 98023 216876 90313532
Headache 174.51 19.35 426 97613 862320 89668088
Irritable bowel syndrome 171.80 19.35 14 98025 207434 90322974
Blister 166.84 19.35 36 98003 254962 90275446
Injury 164.31 19.35 13 98026 197336 90333072
Wheezing 161.18 19.35 31 98008 238049 90292359
Product use in unapproved indication 152.67 19.35 87 97952 336149 90194259
Computerised tomogram thorax abnormal 145.67 19.35 62 97977 2025 90528383
Psoriasis 145.04 19.35 3 98036 147751 90382657
Drug interaction 142.97 19.35 60 97979 276393 90254015
Toxicity to various agents 140.22 19.35 68 97971 287778 90242630
Joint range of motion decreased 132.17 19.35 3 98036 135640 90394768
Discomfort 131.82 19.35 66 97973 274269 90256139
Contusion 129.13 19.35 55 97984 251161 90279247
Bursitis 127.94 19.35 3 98036 131651 90398757
Pain 127.53 19.35 600 97439 995741 89534667
Rash 126.63 19.35 440 97599 795660 89734748
Intentional medical device removal by patient 120.06 19.35 29 98010 129 90530279
Computerised tomogram 119.64 19.35 21 98018 3 90530405
Mobility decreased 119.44 19.35 61 97978 250673 90279735
Sleep disorder due to general medical condition, insomnia type 117.68 19.35 5 98034 128689 90401719
Mucosal inflammation 117.38 19.35 218 97821 57407 90473001
Therapeutic product effect incomplete 115.88 19.35 33 98006 193863 90336545
Hypersensitivity 114.13 19.35 198 97841 454479 90075929
Arthralgia 113.48 19.35 446 97593 778076 89752332
Intercepted medication error 113.47 19.35 41 97998 856 90529552
Migraine 112.68 19.35 33 98006 190359 90340049
Ill-defined disorder 111.36 19.35 31 98008 184860 90345548
Neuropathy peripheral 110.67 19.35 363 97676 136607 90393801
Confusional state 107.47 19.35 157 97882 386048 90144360
C-reactive protein abnormal 107.16 19.35 8 98031 127421 90402987
Arthritis 104.67 19.35 26 98013 167289 90363119
Lower respiratory tract infection 103.88 19.35 72 97967 250587 90279821
Fall 103.49 19.35 230 97809 481580 90048828
Hospitalisation 103.05 19.35 339 97700 127761 90402647
Computerised tomogram thorax 101.63 19.35 33 98006 492 90529916
Blood pressure increased 101.62 19.35 43 97996 197174 90333234
Arteritis 100.18 19.35 35 98004 660 90529748
Leukopenia 100.11 19.35 287 97752 100423 90429985
Device alarm issue 99.39 19.35 46 97993 1839 90528569
Leukocytosis 96.57 19.35 142 97897 30848 90499560
Injury associated with device 96.03 19.35 60 97979 4404 90526004
Dry mouth 95.04 19.35 40 97999 184019 90346389
Application site extravasation 93.29 19.35 16 98023 0 90530408
Atelectasis 92.71 19.35 123 97916 24286 90506122
Prescribed overdose 91.98 19.35 3 98036 97622 90432786
Neutropenic sepsis 90.82 19.35 105 97934 18025 90512383
Dizziness 90.68 19.35 330 97709 588954 89941454
Sleep disorder 90.16 19.35 51 97988 197979 90332429
Gastrooesophageal reflux disease 89.39 19.35 34 98005 166303 90364105
Wrong technique in device usage process 88.27 19.35 63 97976 5772 90524636
Platelet count decreased 86.63 19.35 335 97704 136634 90393774
Facet joint syndrome 86.20 19.35 5 98034 98384 90432024
Application site injury 82.72 19.35 16 98023 15 90530393
Memory impairment 82.59 19.35 56 97983 197188 90333220
Amnesia 80.39 19.35 11 98028 108494 90421914
Acute kidney injury 79.90 19.35 140 97899 320247 90210161
Loss of personal independence in daily activities 79.78 19.35 24 98015 136081 90394327
Thrombocytopenia 79.58 19.35 440 97599 208285 90322123
Road traffic accident 79.53 19.35 11 98028 107615 90422793
Application site discolouration 79.46 19.35 32 98007 906 90529502
Application site mass 78.89 19.35 17 98022 39 90530369
Lower limb fracture 78.74 19.35 3 98036 85010 90445398
Palmar-plantar erythrodysaesthesia syndrome 78.23 19.35 122 97917 27901 90502507
Bronchitis 76.16 19.35 35 98004 152892 90377516
Device deployment issue 74.26 19.35 53 97986 4856 90525552
Sciatica 73.43 19.35 11 98028 101371 90429037
Application site swelling 72.33 19.35 27 98012 620 90529788
Anxiety 72.23 19.35 141 97898 309631 90220777
Liver disorder 71.77 19.35 21 98018 121248 90409160
Alopecia 71.73 19.35 284 97755 494787 90035621
Gait disturbance 71.34 19.35 107 97932 260389 90270019
Urticaria 69.81 19.35 146 97893 312588 90217820
Delirium 69.72 19.35 14 98025 104345 90426063
Gait inability 69.16 19.35 36 98003 146420 90383988
Abdominal pain upper 68.77 19.35 162 97877 332512 90197896
Suicide attempt 68.69 19.35 3 98036 75396 90455012
Device mechanical issue 67.42 19.35 30 98009 1093 90529315
Application site reaction 65.80 19.35 27 98012 803 90529605
Febrile bone marrow aplasia 65.66 19.35 66 97973 9672 90520736
Wound infection 65.64 19.35 17 98022 106385 90424023
Hypoaesthesia 64.95 19.35 153 97886 314057 90216351
Drug-induced liver injury 64.95 19.35 10 98029 90308 90440100
Overdose 64.39 19.35 46 97993 157663 90372745
Staphylococcal bacteraemia 62.45 19.35 57 97982 7412 90522996
Prescribed underdose 62.25 19.35 5 98034 75014 90455394
Inflammation 61.96 19.35 61 97978 178531 90351877
Dyspepsia 61.76 19.35 74 97965 198086 90332322
Product quality issue 61.30 19.35 7 98032 79318 90451090
Somnolence 61.09 19.35 82 97957 209002 90321406
Suicidal ideation 61.07 19.35 5 98034 73850 90456558
Muscle spasms 61.04 19.35 112 97927 251771 90278637
Aortic wall hypertrophy 60.89 19.35 13 98026 28 90530380
Oedema 60.11 19.35 77 97962 200218 90330190
Ear infection 59.76 19.35 4 98035 69771 90460637
Device material issue 59.48 19.35 21 98018 409 90529999
Obesity 59.35 19.35 20 98019 105487 90424921
Insomnia 58.61 19.35 176 97863 333298 90197110
Incorrect dose administered 58.26 19.35 203 97836 78727 90451681
Device defective 58.24 19.35 40 97999 3446 90526962
Application site haematoma 57.85 19.35 12 98027 21 90530387
Drug abuse 57.24 19.35 10 98029 82337 90448071
Epilepsy 57.11 19.35 10 98029 82196 90448212
Pneumonia 56.61 19.35 431 97608 637628 89892780
Osteoporosis 56.60 19.35 17 98022 96514 90433894
Alopecia areata 56.15 19.35 32 98007 1983 90528425
Pulmonary fibrosis 56.06 19.35 23 98016 107480 90422928
Oral pain 56.03 19.35 115 97924 32568 90497840
White blood cell count increased 55.89 19.35 180 97859 67061 90463347
Red blood cell sedimentation rate increased 55.34 19.35 11 98028 82584 90447824
Neutropenic colitis 54.24 19.35 41 97998 4102 90526306
Drug ineffective for unapproved indication 53.77 19.35 5 98034 66639 90463769
Autoimmune disorder 51.88 19.35 10 98029 76734 90453674
Blood pressure systolic increased 51.00 19.35 3 98036 58342 90472066
Infection 50.96 19.35 210 97829 361884 90168524
Product storage error 50.86 19.35 84 97955 20157 90510251
Cataract 49.58 19.35 9 98030 72083 90458325
Frequent bowel movements 49.54 19.35 3 98036 56932 90473476
COVID-19 49.54 19.35 66 97973 168777 90361631
Anaemia 49.33 19.35 591 97448 352211 90178197
Application site irritation 48.97 19.35 29 98010 1932 90528476
Hair colour changes 48.92 19.35 36 98003 3458 90526950
Heart rate abnormal 48.82 19.35 45 97994 5926 90524482
Device monitoring procedure not performed 48.50 19.35 9 98030 5 90530403
Coma 47.98 19.35 10 98029 72622 90457786
Cerebrovascular accident 47.90 19.35 38 98001 123495 90406913
Pancytopenia 47.46 19.35 256 97783 120007 90410401
Inappropriate schedule of product administration 47.41 19.35 301 97738 149632 90380776
Colitis ulcerative 47.37 19.35 5 98034 60261 90470147
Cardiac failure congestive 46.98 19.35 24 98015 98670 90431738
Pneumocystis jirovecii pneumonia 46.82 19.35 84 97955 21532 90508876
Myalgia 45.51 19.35 335 97704 174790 90355618
Muscular weakness 44.82 19.35 98 97941 206568 90323840
Application site pruritus 44.79 19.35 37 98002 4210 90526198
Liver function test increased 44.50 19.35 18 98021 84837 90445571
Pregnancy 44.32 19.35 7 98032 62040 90468368
Hepatitis 44.21 19.35 11 98028 70728 90459680
Peripheral sensory neuropathy 43.71 19.35 52 97987 9198 90521210
Bradycardia 43.62 19.35 18 98021 83829 90446579
Nasal congestion 43.25 19.35 18 98021 83396 90447012
Myocardial infarction 43.13 19.35 31 98008 105941 90424467
Weight decreased 42.57 19.35 239 97800 379671 90150737
Electrocardiogram QT prolonged 42.05 19.35 13 98026 72443 90457965
Lung disorder 41.56 19.35 61 97978 149822 90380586
Stress 41.50 19.35 18 98021 81377 90449031
Nail bed inflammation 40.75 19.35 25 98014 1776 90528632
Heart rate decreased 40.65 19.35 5 98034 53500 90476908
Sedation 40.56 19.35 3 98036 48168 90482240
Seizure 40.51 19.35 64 97975 152565 90377843
Joint stiffness 40.20 19.35 17 98022 78025 90452383
Visual impairment 39.58 19.35 51 97988 132314 90398094
Carotidynia 39.57 19.35 12 98027 141 90530267
Rectal haemorrhage 39.56 19.35 20 98019 82724 90447684
Illness 38.91 19.35 20 98019 81949 90448459
Treatment noncompliance 38.89 19.35 5 98034 51722 90478686
Abortion spontaneous 38.83 19.35 6 98033 54050 90476358
Upper respiratory tract infection 38.83 19.35 49 97990 128269 90402139
Night sweats 38.11 19.35 50 97989 128716 90401692
Renal impairment 37.73 19.35 35 98004 105386 90425022
Nasal mucosal disorder 37.54 19.35 24 98015 1833 90528575
Lymphadenitis 37.41 19.35 33 98006 4104 90526304
Streptococcal sepsis 37.33 19.35 31 98008 3553 90526855
Sleep disorder due to a general medical condition 37.06 19.35 3 98036 44735 90485673
Madarosis 36.99 19.35 31 98008 3598 90526810
Fluid retention 36.87 19.35 25 98014 88066 90442342
Gastrointestinal disorder 36.63 19.35 148 97891 256539 90273869
Injection site reaction 36.10 19.35 28 98011 92052 90438356
Hair texture abnormal 35.78 19.35 34 98005 4653 90525755
Dehydration 35.65 19.35 344 97695 194103 90336305
Therapy non-responder 35.64 19.35 58 97981 136646 90393762
Pneumonitis 35.58 19.35 117 97922 44053 90486355
Medication error 35.46 19.35 24 98015 84628 90445780
Influenza 35.46 19.35 60 97979 139204 90391204
Foetal exposure during pregnancy 35.28 19.35 3 98036 42972 90487436
Ultrasound scan 34.98 19.35 6 98033 0 90530408
Hypoglycaemia 34.74 19.35 16 98023 69832 90460576
Injection site pruritus 34.37 19.35 8 98031 53826 90476582
Pseudomonal sepsis 34.36 19.35 32 98007 4270 90526138
Neutrophil count increased 34.15 19.35 69 97970 19321 90511087
Blood magnesium decreased 34.01 19.35 61 97978 15632 90514776
Pancreatitis 33.20 19.35 17 98022 69809 90460599
Depressed level of consciousness 32.74 19.35 19 98020 72765 90457643
Injection site erythema 32.62 19.35 35 98004 98467 90431941
Dry eye 32.54 19.35 11 98028 57920 90472488
Blood glucose increased 32.49 19.35 33 98006 95213 90435195
Vision blurred 32.46 19.35 43 97996 110250 90420158
Metabolic acidosis 32.29 19.35 10 98029 55666 90474742
Vasculitis 32.21 19.35 74 97965 22619 90507789
Radiotherapy 31.98 19.35 17 98022 918 90529490
Intentional product misuse 31.77 19.35 30 98009 89574 90440834
Interstitial lung disease 31.75 19.35 165 97874 76240 90454168
Lactic acidosis 31.24 19.35 8 98031 50455 90479953
Sepsis 30.96 19.35 314 97725 179500 90350908
Disability 30.49 19.35 4 98035 40741 90489667
Nephrolithiasis 29.97 19.35 8 98031 49077 90481331
Pulmonary hypertension 29.91 19.35 5 98034 42518 90487890
Unevaluable event 29.77 19.35 128 97911 54720 90475688
Cystitis haemorrhagic 29.42 19.35 33 98006 5480 90524928
Left ventricular dysfunction 29.24 19.35 55 97984 14614 90515794
Femur fracture 29.12 19.35 7 98032 46075 90484333
Capillary leak syndrome 28.96 19.35 24 98015 2743 90527665
Hypersensitivity pneumonitis 28.93 19.35 28 98011 3920 90526488
Hallucination 28.58 19.35 18 98021 65941 90464467
Premature delivery 28.54 19.35 4 98035 38758 90491650
Poor quality device used 28.50 19.35 22 98017 2271 90528137
Oedema peripheral 28.46 19.35 163 97876 257752 90272656
Neutropenic infection 28.45 19.35 20 98019 1789 90528619
Body temperature abnormal 28.03 19.35 23 98016 2592 90527816
Mastectomy 27.99 19.35 21 98018 2078 90528330
Recall phenomenon 27.82 19.35 15 98024 834 90529574
Gastrointestinal haemorrhage 27.79 19.35 34 98005 90214 90440194
Walking aid user 27.77 19.35 3 98036 35503 90494905
Diabetes mellitus 27.70 19.35 18 98021 64857 90465551
Blood pressure fluctuation 27.67 19.35 11 98028 52402 90478006
Tongue coated 27.08 19.35 19 98020 1694 90528714
Chronic obstructive pulmonary disease 27.03 19.35 24 98015 73805 90456603
Hepatotoxicity 27.00 19.35 8 98031 45834 90484574
Vascular device infection 26.60 19.35 47 97992 11905 90518503
International normalised ratio increased 26.55 19.35 9 98030 47307 90483101
Injection site haemorrhage 26.49 19.35 79 97960 28239 90502169
Taste disorder 26.38 19.35 17 98022 61529 90468879
Therapeutic procedure 26.30 19.35 15 98024 931 90529477
Laryngitis 26.23 19.35 11 98028 50742 90479666
Tremor 26.05 19.35 82 97957 153091 90377317
Splenic rupture 25.95 19.35 17 98022 1354 90529054
Acute febrile neutrophilic dermatosis 25.71 19.35 25 98014 3520 90526888
White blood cell disorder 25.53 19.35 23 98016 2941 90527467
Application site warmth 25.52 19.35 10 98029 263 90530145
Basal ganglion degeneration 25.51 19.35 11 98028 371 90530037
Cardiac arrest 25.09 19.35 47 97992 104888 90425520
Melaena 24.68 19.35 4 98035 34793 90495615
Immunodeficiency 24.65 19.35 8 98031 43226 90487182
Stomatitis 24.55 19.35 185 97854 274513 90255895
Hyperleukocytosis 24.49 19.35 14 98025 873 90529535
Breast cancer metastatic 24.48 19.35 52 97987 15080 90515328
Vascular fragility 24.14 19.35 9 98030 206 90530202
Vein discolouration 24.01 19.35 10 98029 309 90530099
Infective aortitis 23.94 19.35 6 98033 32 90530376
Endoscopic retrograde cholangiopancreatography 23.89 19.35 9 98030 212 90530196
Metastases to central nervous system 23.58 19.35 56 97983 17486 90512922
Refusal of treatment by patient 23.48 19.35 30 98009 5708 90524700
Anaesthesia 23.46 19.35 11 98028 453 90529955
Application site cellulitis 23.32 19.35 4 98035 0 90530408
Respiratory arrest 23.25 19.35 4 98035 33307 90497101
Agitation 23.16 19.35 23 98016 67075 90463333
Disturbance in attention 23.10 19.35 11 98028 47098 90483310
Transient ischaemic attack 22.89 19.35 9 98030 43167 90487241
Balance disorder 22.76 19.35 44 97995 97036 90433372
Generalised tonic-clonic seizure 22.65 19.35 5 98034 34898 90495510
Respiratory disorder 22.63 19.35 22 98017 64794 90465614
Aphasia 22.58 19.35 9 98030 42803 90487605
Application site urticaria 22.47 19.35 9 98030 251 90530157
Injection site swelling 22.45 19.35 19 98020 59820 90470588
Metastases to lymph nodes 22.28 19.35 43 97996 11646 90518762
Sinus disorder 22.23 19.35 5 98034 34442 90495966
Varicose vein 22.00 19.35 33 98006 7294 90523114
Lymphadenopathy 21.97 19.35 103 97936 45672 90484736
Blood creatine increased 21.81 19.35 32 98007 6935 90523473
Eye irritation 21.79 19.35 5 98034 33973 90496435
Orthostatic hypotension 21.72 19.35 9 98030 41818 90488590
Hypotension 21.72 19.35 236 97803 325161 90205247
Haematemesis 21.55 19.35 5 98034 33721 90496687
Device dislocation 21.54 19.35 79 97960 31403 90499005
Movement disorder 21.35 19.35 3 98036 29016 90501392
Drug reaction with eosinophilia and systemic symptoms 20.95 19.35 10 98029 42748 90487660
Acne 20.85 19.35 3 98036 28504 90501904
Rhabdomyolysis 20.85 19.35 15 98024 51241 90479167
Abdominal distension 20.77 19.35 72 97967 130529 90399879
Hypervolaemia 20.65 19.35 5 98034 32752 90497656
Cholelithiasis 20.54 19.35 16 98023 52490 90477918
Dyskinesia 20.41 19.35 7 98032 36527 90493881
Therapy interrupted 19.94 19.35 15 98024 50093 90480315
Skin ulcer 19.92 19.35 15 98024 50060 90480348
Tissue infiltration 19.49 19.35 12 98027 858 90529550
Respiratory depth decreased 19.45 19.35 5 98034 30 90530378
Hyperkalaemia 19.45 19.35 25 98014 64939 90465469

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device adhesion issue 19743.82 19.50 3441 46178 193 42571523
Unintentional medical device removal 15240.82 19.50 2711 46908 480 42571236
Wrong technique in product usage process 7580.70 19.50 2543 47076 40092 42531624
Device use error 7525.00 19.50 1500 48119 1697 42570019
Device malfunction 6273.01 19.50 1661 47958 10666 42561050
Device occlusion 4622.72 19.50 1207 48412 7243 42564473
Device issue 3459.73 19.50 1067 48552 12442 42559274
Accidental exposure to product 2374.01 19.50 892 48727 19501 42552215
Application site haemorrhage 2113.48 19.50 382 49237 98 42571618
Drug dose omission by device 2111.76 19.50 604 49015 5282 42566434
Device physical property issue 1283.91 19.50 307 49312 1187 42570529
Application site pain 1003.40 19.50 276 49343 2053 42569663
Febrile neutropenia 863.19 19.50 1069 48550 184634 42387082
Investigation 725.57 19.50 177 49442 758 42570958
Intercepted product preparation error 704.52 19.50 280 49339 7109 42564607
Device power source issue 695.90 19.50 158 49461 456 42571260
Device electrical finding 620.74 19.50 112 49507 27 42571689
Device leakage 587.01 19.50 271 49348 10014 42561702
Application site discomfort 542.87 19.50 97 49522 17 42571699
Device failure 450.19 19.50 155 49464 2588 42569128
Incorrect disposal of product 426.87 19.50 99 49520 323 42571393
Product dose omission issue 411.19 19.50 683 48936 153682 42418034
Underdose 346.24 19.50 225 49394 16441 42555275
Incorrect dose administered by device 328.86 19.50 123 49496 2633 42569083
Bone pain 319.43 19.50 246 49373 23546 42548170
Neutropenia 308.03 19.50 701 48918 198730 42372986
Product preparation error 298.09 19.50 134 49485 4644 42567072
Application site bruise 283.68 19.50 51 49568 11 42571705
Hyperhidrosis 276.91 19.50 427 49192 90085 42481631
Occupational exposure to product 250.81 19.50 65 49554 372 42571344
Device delivery system issue 231.82 19.50 74 49545 963 42570753
Device placement issue 222.37 19.50 46 49573 70 42571646
Drug ineffective 203.11 19.50 263 49356 629934 41941782
Drug interaction 187.52 19.50 41 49578 266958 42304758
Circumstance or information capable of leading to medication error 187.21 19.50 80 49539 2448 42569268
Death 185.50 19.50 1054 48565 470131 42101585
Toxicity to various agents 173.98 19.50 29 49590 229107 42342609
Drug delivery system malfunction 173.17 19.50 50 49569 451 42571265
Magnetic resonance imaging 169.86 19.50 30 49589 3 42571713
Hospitalisation 167.51 19.50 306 49313 74024 42497692
Intercepted product administration error 163.77 19.50 49 49570 506 42571210
Chemotherapy 161.70 19.50 53 49566 754 42570962
Colony stimulating factor therapy 160.58 19.50 39 49580 163 42571553
Condition aggravated 148.53 19.50 59 49560 260695 42311021
Neutrophil count decreased 129.08 19.50 250 49369 63165 42508551
Needle issue 123.15 19.50 93 49526 8634 42563082
Product communication issue 109.06 19.50 43 49576 1066 42570650
White blood cell count abnormal 104.64 19.50 61 49558 3664 42568052
Neutrophil count abnormal 101.41 19.50 54 49565 2717 42568999
Off label use 99.65 19.50 1156 48463 637179 41934537
Aortitis 95.84 19.50 34 49585 622 42571094
Device deployment issue 92.10 19.50 33 49586 622 42571094
Hypertension 78.28 19.50 49 49570 167155 42404561
Depression 78.24 19.50 17 49602 111346 42460370
Blood pressure increased 74.85 19.50 14 49605 101914 42469802
Bradycardia 74.02 19.50 7 49612 85477 42486239
Acute kidney injury 68.78 19.50 210 49409 367127 42204589
Drug intolerance 68.55 19.50 7 49612 80417 42491299
Rash 67.66 19.50 138 49481 276816 42294900
Somnolence 66.52 19.50 41 49578 141064 42430652
Device mechanical issue 65.88 19.50 30 49589 1071 42570645
Intercepted medication error 65.25 19.50 24 49595 489 42571227
Application site extravasation 63.33 19.50 11 49608 0 42571716
Wrong technique in device usage process 61.62 19.50 39 49580 2718 42568998
Arteritis 61.44 19.50 23 49596 493 42571223
Dizziness 61.03 19.50 124 49495 249130 42322586
Seizure 58.26 19.50 34 49585 120527 42451189
Renal impairment 57.80 19.50 28 49591 110200 42461516
Pyrexia 57.74 19.50 706 48913 393336 42178380
Intentional medical device removal by patient 57.69 19.50 21 49598 415 42571301
Intentional product use issue 56.91 19.50 8 49611 71825 42499891
Device alarm issue 55.18 19.50 24 49595 767 42570949
Weight increased 54.27 19.50 29 49590 107954 42463762
Neutropenic sepsis 54.01 19.50 79 49540 15867 42555849
Therapeutic procedure 53.61 19.50 18 49601 277 42571439
Hallucination 51.72 19.50 4 49615 57503 42514213
Confusional state 51.49 19.50 72 49547 167525 42404191
Pruritus 51.40 19.50 88 49531 188683 42383033
Rhabdomyolysis 50.71 19.50 14 49605 78005 42493711
Cerebrovascular accident 50.45 19.50 25 49594 97135 42474581
Cardiac arrest 49.82 19.50 33 49586 109287 42462429
Drug hypersensitivity 49.50 19.50 27 49592 99362 42472354
Therapeutic product effect incomplete 49.46 19.50 11 49608 70928 42500788
Myocardial infarction 49.39 19.50 43 49576 123966 42447750
Tremor 48.75 19.50 26 49593 96903 42474813
Product use in unapproved indication 48.40 19.50 88 49531 184368 42387348
Weight decreased 47.91 19.50 107 49512 207841 42363875
Hyperkalaemia 47.72 19.50 17 49602 80441 42491275
Overdose 47.66 19.50 32 49587 105232 42466484
Leukocytosis 47.36 19.50 106 49513 29602 42542114
Anxiety 47.35 19.50 41 49578 118519 42453197
Agitation 46.85 19.50 9 49610 64305 42507411
Fall 46.77 19.50 130 49489 234390 42337326
White blood cell count decreased 45.68 19.50 251 49368 110145 42461571
Coronary artery disease 44.94 19.50 5 49614 53715 42518001
Psoriasis 44.80 19.50 3 49616 48601 42523115
Intentional product misuse 44.38 19.50 9 49610 61891 42509825
Blood creatinine increased 43.98 19.50 38 49581 109965 42461751
Bone marrow necrosis 41.70 19.50 15 49604 286 42571430
Fat embolism syndrome 41.58 19.50 11 49608 69 42571647
International normalised ratio increased 41.54 19.50 4 49615 48164 42523552
Suicidal ideation 41.53 19.50 4 49615 48157 42523559
Headache 41.12 19.50 142 49477 239227 42332489
Application site injury 40.30 19.50 7 49612 0 42571716
Cardiac failure congestive 40.14 19.50 25 49594 85577 42486139
Febrile bone marrow aplasia 39.76 19.50 54 49565 10127 42561589
Application site swelling 39.75 19.50 15 49604 329 42571387
Blood glucose increased 39.74 19.50 18 49601 73681 42498035
Dyspnoea 38.58 19.50 330 49289 442291 42129425
Coma 37.95 19.50 8 49611 53546 42518170
Renal failure 37.30 19.50 69 49550 143657 42428059
Stress 37.28 19.50 4 49615 44208 42527508
Asthma 37.23 19.50 13 49606 62301 42509415
Cardio-respiratory arrest 37.22 19.50 11 49608 58625 42513091
Blood creatine phosphokinase increased 36.87 19.50 6 49613 48332 42523384
Application site mass 36.35 19.50 8 49611 19 42571697
Foetal exposure during pregnancy 35.80 19.50 6 49613 47305 42524411
Neutropenic infection 35.75 19.50 24 49595 1849 42569867
Device defective 35.55 19.50 23 49596 1665 42570051
Application site erythema 35.43 19.50 27 49592 2539 42569177
Computerised tomogram 34.99 19.50 8 49611 24 42571692
Cardiac failure 34.74 19.50 44 49575 106812 42464904
Drug ineffective for unapproved indication 34.61 19.50 6 49613 46157 42525559
Wheezing 33.47 19.50 11 49608 54770 42516946
Gait disturbance 33.28 19.50 39 49580 97961 42473755
Musculoskeletal stiffness 32.91 19.50 13 49606 57752 42513964
Abdominal discomfort 32.58 19.50 24 49595 75231 42496485
Metabolic acidosis 32.42 19.50 10 49609 51848 42519868
Pulmonary oedema 32.02 19.50 11 49608 53261 42518455
Diabetes mellitus 31.89 19.50 15 49604 60072 42511644
Heart rate decreased 31.59 19.50 3 49616 36529 42535187
Product use issue 31.30 19.50 26 49593 76725 42494991
Failure to anastomose 30.57 19.50 11 49608 210 42571506
Nasopharyngitis 30.09 19.50 32 49587 83964 42487752
Thrombocytopenia 29.97 19.50 346 49273 189933 42381783
Lactic acidosis 29.63 19.50 8 49611 45253 42526463
Joint swelling 29.05 19.50 22 49597 68000 42503716
Loss of consciousness 29.02 19.50 39 49580 92315 42479401
Peripheral swelling 28.48 19.50 38 49581 90232 42481484
Phlebitis infective 27.92 19.50 9 49610 121 42571595
Hypotension 27.66 19.50 181 49438 257450 42314266
Haematochezia 27.48 19.50 17 49602 58419 42513297
Febrile infection 27.39 19.50 24 49595 2747 42568969
Haematuria 26.93 19.50 17 49602 57782 42513934
Palpitations 26.47 19.50 13 49606 50784 42520932
Chronic kidney disease 26.31 19.50 11 49608 47230 42524486
Tubulointerstitial nephritis 26.22 19.50 3 49616 31545 42540171
Gastrointestinal haemorrhage 26.16 19.50 46 49573 97680 42474036
Treatment noncompliance 25.94 19.50 6 49613 37666 42534050
Granulocytopenia neonatal 25.54 19.50 6 49613 21 42571695
Gastritis bacterial 25.54 19.50 11 49608 343 42571373
Haemorrhage 25.33 19.50 20 49599 60543 42511173
Oedema peripheral 25.22 19.50 78 49541 135998 42435718
Cataract 25.22 19.50 3 49616 30601 42541115
Myeloblast count increased 25.12 19.50 6 49613 23 42571693
Expired device used 25.10 19.50 9 49610 170 42571546
Drug reaction with eosinophilia and systemic symptoms 24.75 19.50 9 49610 42066 42529650
Hypoglycaemia 24.74 19.50 20 49599 59834 42511882
Ventricular fibrillation 24.70 19.50 3 49616 30120 42541596
Disturbance in attention 24.43 19.50 3 49616 29863 42541853
Perihepatic abscess 24.26 19.50 8 49611 116 42571600
Loss of personal independence in daily activities 24.12 19.50 14 49605 49802 42521914
Cardiogenic shock 23.90 19.50 6 49613 35634 42536082
Urticaria 23.52 19.50 31 49588 74005 42497711
Neuropathy peripheral 22.67 19.50 199 49420 101654 42470062
Arthralgia 22.62 19.50 143 49476 205095 42366621
COVID-19 22.53 19.50 65 49554 115883 42455833
Depressed level of consciousness 22.49 19.50 14 49605 47956 42523760
Eczema 22.36 19.50 6 49613 34080 42537636
Angioedema 21.93 19.50 11 49608 42466 42529250
Arthropathy 21.85 19.50 4 49615 29593 42542123
Abdominal distension 21.82 19.50 31 49588 71704 42500012
Alanine aminotransferase increased 21.57 19.50 44 49575 88362 42483354
Multiple organ dysfunction syndrome 21.45 19.50 51 49568 96984 42474732
Drug-induced liver injury 21.17 19.50 9 49610 38264 42533452
Dry mouth 21.09 19.50 10 49609 39869 42531847
Jaundice 21.03 19.50 7 49612 34582 42537134
Dysarthria 21.02 19.50 10 49609 39797 42531919
Vision blurred 20.91 19.50 19 49600 53680 42518036
Mastitis 20.85 19.50 8 49611 184 42571532
Cardiac disorder 20.67 19.50 16 49603 48916 42522800
Hyponatraemia 20.36 19.50 56 49563 101406 42470310
Pancytopenia 20.29 19.50 218 49401 117525 42454191
Rectal haemorrhage 19.98 19.50 17 49602 49589 42522127
Sleep disorder 19.97 19.50 16 49603 48079 42523637
Acute myocardial infarction 19.90 19.50 23 49596 58142 42513574
Splenic rupture 19.87 19.50 16 49603 1631 42570085
Migraine 19.73 19.50 3 49616 25411 42546305
Blister 19.69 19.50 4 49615 27486 42544230
Prostate cancer 19.62 19.50 14 49605 44629 42527087
Angiodysplasia 19.51 19.50 12 49607 795 42570921

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device adhesion issue 51136.33 18.06 8782 109317 528 110470672
Unintentional medical device removal 38890.28 18.06 6921 111178 2002 110469198
Wrong technique in product usage process 19577.60 18.06 6083 112016 81265 110389935
Device use error 19161.41 18.06 3834 114265 5255 110465945
Device malfunction 18401.39 18.06 4464 113635 21094 110450106
Device occlusion 11070.16 18.06 2683 115416 12502 110458698
Device issue 9019.61 18.06 2714 115385 31821 110439379
Accidental exposure to product 7039.99 18.06 2460 115639 47548 110423652
Drug dose omission by device 5059.48 18.06 1429 116670 13087 110458113
Application site haemorrhage 4881.71 18.06 912 117187 584 110470616
Device physical property issue 3937.96 18.06 894 117205 2900 110468300
Intercepted product preparation error 3186.97 18.06 846 117253 5974 110465226
Application site pain 2745.69 18.06 719 117380 4780 110466420
Device leakage 2410.46 18.06 830 117269 15218 110455982
Febrile neutropenia 2272.23 18.06 2200 115899 314567 110156633
Device electrical finding 1721.38 18.06 302 117797 47 110471153
Device power source issue 1716.08 18.06 376 117723 981 110470219
Investigation 1508.52 18.06 375 117724 1957 110469243
Bone pain 1415.43 18.06 876 117223 64257 110406943
Application site discomfort 1264.52 18.06 240 117859 187 110471013
Application site bruise 991.91 18.06 187 117912 134 110471066
Neutropenia 964.58 18.06 1557 116542 373063 110098137
Device failure 941.01 18.06 336 117763 6871 110464329
Incorrect disposal of product 916.64 18.06 225 117874 1103 110470097
Product dose omission issue 878.39 18.06 1374 116725 320408 110150792
Incorrect dose administered by device 872.03 18.06 313 117786 6501 110464699
Product preparation error 853.99 18.06 350 117749 10529 110460671
Underdose 652.92 18.06 542 117557 63012 110408188
Intercepted product administration error 572.86 18.06 142 117957 730 110470470
Drug ineffective 553.43 18.06 489 117610 1520051 108951149
Aortitis 523.07 18.06 158 117941 1857 110469343
Chemotherapy 446.34 18.06 142 117957 2004 110469196
Needle issue 420.60 18.06 253 117846 17587 110453613
Device placement issue 393.52 18.06 124 117975 1693 110469507
Device delivery system issue 386.01 18.06 127 117972 2006 110469194
Magnetic resonance imaging 368.45 18.06 72 118027 77 110471123
Condition aggravated 367.21 18.06 163 117936 734673 109736527
Neutrophil count abnormal 361.95 18.06 153 117946 4979 110466221
Circumstance or information capable of leading to medication error 359.07 18.06 153 117946 5080 110466120
Product communication issue 350.56 18.06 123 117976 2383 110468817
Death 346.78 18.06 1570 116529 697299 109773901
Hyperhidrosis 340.90 18.06 670 117429 186628 110284572
Neutrophil count decreased 334.07 18.06 520 117579 120421 110350779
Hospitalisation 327.76 18.06 564 117535 141929 110329271
White blood cell count abnormal 321.39 18.06 154 117945 6755 110464445
Drug intolerance 306.68 18.06 37 118062 406475 110064725
Colony stimulating factor therapy 291.98 18.06 78 118021 564 110470636
Joint swelling 289.77 18.06 60 118039 442785 110028415
Toxicity to various agents 287.16 18.06 79 118020 480476 109990724
Drug interaction 282.93 18.06 91 118008 500092 109971108
Rheumatoid arthritis 275.71 18.06 10 118089 299603 110171597
Hypertension 274.36 18.06 101 117998 509983 109961217
Drug hypersensitivity 256.10 18.06 83 118016 454007 110017193
Treatment failure 255.97 18.06 9 118090 277225 110193975
Drug delivery system malfunction 250.90 18.06 77 118022 958 110470242
Weight increased 250.65 18.06 69 118030 419575 110051625
Contraindicated product administered 248.97 18.06 3 118096 248264 110222936
Maternal exposure during pregnancy 223.02 18.06 12 118087 254871 110216329
White blood cell count decreased 221.22 18.06 641 117458 228749 110242451
Hepatic enzyme increased 217.15 18.06 40 118059 320852 110150348
Pericarditis 209.99 18.06 5 118094 219109 110252091
Depression 207.48 18.06 43 118056 317292 110153908
Hand deformity 205.60 18.06 6 118093 218500 110252700
Abdominal discomfort 200.16 18.06 85 118014 393773 110077427
Peripheral swelling 196.24 18.06 93 118006 403941 110067259
Headache 195.68 18.06 406 117693 881971 109589229
Musculoskeletal stiffness 195.63 18.06 32 118067 279790 110191410
Pruritus 189.57 18.06 205 117894 581355 109889845
Swelling 189.49 18.06 69 118030 350972 110120228
Infusion related reaction 189.35 18.06 85 118014 381077 110090123
Product use in unapproved indication 188.39 18.06 123 117976 447254 110023946
Intentional product use issue 188.26 18.06 22 118077 247884 110223316
Sinusitis 186.29 18.06 44 118055 296644 110174556
Asthma 185.69 18.06 24 118075 250267 110220933
Nasopharyngitis 180.70 18.06 98 118001 394263 110076937
Helicobacter infection 178.87 18.06 3 118096 181874 110289326
Wheezing 174.42 18.06 31 118068 255199 110216001
Product use issue 170.37 18.06 60 118039 311635 110159565
Pyrexia 169.86 18.06 1581 116518 896684 109574516
Osteoarthritis 168.29 18.06 6 118093 182617 110288583
Fibromyalgia 167.33 18.06 3 118096 170906 110300294
Arteritis 164.01 18.06 57 118042 1072 110470128
Therapeutic product effect decreased 161.98 18.06 32 118067 244284 110226916
Impaired healing 161.07 18.06 13 118086 196704 110274496
Glossodynia 158.30 18.06 24 118075 221980 110249220
Wound 156.91 18.06 30 118069 234407 110236793
Type 2 diabetes mellitus 156.10 18.06 8 118091 177224 110293976
Acute kidney injury 154.98 18.06 276 117823 635154 109836046
Folliculitis 152.79 18.06 6 118093 167647 110303553
Exposure during pregnancy 152.55 18.06 6 118093 167418 110303782
Blister 150.28 18.06 30 118069 227346 110243854
Drug abuse 150.18 18.06 10 118089 177401 110293799
Wrong technique in device usage process 150.18 18.06 93 118006 6808 110464392
Application site erythema 149.13 18.06 86 118013 5524 110465676
Blood pressure increased 147.74 18.06 46 118053 258327 110212873
Neuropathy peripheral 145.69 18.06 472 117627 178805 110292395
Intentional medical device removal by patient 145.58 18.06 43 118056 465 110470735
Rash 141.95 18.06 429 117670 820535 109650665
Intercepted medication error 141.19 18.06 52 118047 1164 110470036
Fall 140.16 18.06 270 117829 603212 109867988
Injury 138.97 18.06 14 118085 177251 110293949
Confusional state 138.93 18.06 178 117921 468502 110002698
Therapeutic product effect incomplete 136.94 18.06 35 118064 223770 110247430
Device deployment issue 134.29 18.06 73 118026 4180 110467020
Device mechanical issue 131.69 18.06 57 118042 1967 110469233
Dizziness 131.58 18.06 350 117749 697843 109773357
Psoriasis 131.11 18.06 4 118095 139989 110331211
Computerised tomogram thorax abnormal 129.08 18.06 62 118037 2733 110468467
Irritable bowel syndrome 126.09 18.06 14 118085 164201 110306999
Computerised tomogram 125.74 18.06 22 118077 3 110471197
Bursitis 120.63 18.06 4 118095 129914 110341286
Hypersensitivity 117.06 18.06 156 117943 403842 110067358
Pain 116.75 18.06 574 117525 954381 109516819
Occupational exposure to product 112.85 18.06 40 118059 799 110470401
Contusion 109.76 18.06 56 118043 233305 110237895
Anxiety 109.71 18.06 124 117975 344954 110126246
Migraine 108.61 18.06 25 118074 171627 110299573
Dry mouth 108.35 18.06 39 118060 199909 110271291
Application site extravasation 108.24 18.06 19 118080 3 110471197
Somnolence 105.79 18.06 97 118002 297352 110173848
Arthritis 104.86 18.06 25 118074 167561 110303639
C-reactive protein abnormal 102.29 18.06 10 118089 129685 110341515
Computerised tomogram thorax 101.98 18.06 33 118066 493 110470707
Bradycardia 99.69 18.06 22 118077 155495 110315705
Arthralgia 99.65 18.06 461 117638 779171 109692029
Urticaria 98.73 18.06 117 117982 318740 110152460
Overdose 98.70 18.06 64 118035 233730 110237470
Joint range of motion decreased 97.13 18.06 9 118090 121823 110349377
Suicide attempt 96.65 18.06 3 118096 103391 110367809
Coma 95.89 18.06 8 118091 117861 110353339
Application site mass 90.86 18.06 19 118080 36 110471164
Facet joint syndrome 89.83 18.06 3 118096 96825 110374375
Triple negative breast cancer 89.57 18.06 30 118069 502 110470698
Sleep disorder due to general medical condition, insomnia type 89.26 18.06 6 118093 105637 110365563
Gastrooesophageal reflux disease 87.95 18.06 41 118058 179935 110291265
Lip dry 86.61 18.06 5 118094 100078 110371122
Febrile bone marrow aplasia 84.93 18.06 99 118000 17366 110453834
Discomfort 83.73 18.06 64 118035 214643 110256557
Cerebrovascular accident 83.03 18.06 45 118054 181239 110289961
Sleep disorder 82.99 18.06 55 118044 198589 110272611
Device alarm issue 82.88 18.06 44 118055 2402 110468798
Application site swelling 81.59 18.06 32 118067 855 110470345
Lower respiratory tract infection 80.96 18.06 84 118015 243022 110228178
Hypercholesterolaemia 80.29 18.06 4 118095 90833 110380367
Gait inability 80.25 18.06 23 118076 136353 110334847
Amnesia 78.40 18.06 10 118089 105398 110365802
Memory impairment 77.70 18.06 58 118041 196886 110274314
Gait disturbance 76.96 18.06 111 117988 278097 110193103
Prescribed overdose 76.95 18.06 4 118095 87577 110383623
Muscle spasms 76.93 18.06 111 117988 278046 110193154
Drug-induced liver injury 76.92 18.06 17 118082 120050 110351150
Liver disorder 76.62 18.06 28 118071 142215 110328985
Neutropenic sepsis 76.32 18.06 126 117973 30620 110440580
Drug ineffective for unapproved indication 75.90 18.06 10 118089 102828 110368372
Mobility decreased 75.77 18.06 85 118014 237337 110233863
Road traffic accident 75.65 18.06 12 118087 107386 110363814
Aortic wall hypertrophy 75.30 18.06 16 118083 34 110471166
Loss of personal independence in daily activities 75.14 18.06 33 118066 149987 110321213
Bronchitis 74.85 18.06 37 118062 156995 110314205
Suicidal ideation 74.72 18.06 7 118092 93930 110377270
Seizure 74.13 18.06 76 118023 221109 110250091
Myocardial infarction 73.95 18.06 58 118041 192025 110279175
Electrocardiogram QT prolonged 72.76 18.06 14 118085 108946 110362254
Renal impairment 72.43 18.06 57 118042 188388 110282812
Delirium 72.02 18.06 27 118072 134998 110336202
Ill-defined disorder 70.29 18.06 40 118059 156813 110314387
Weight decreased 70.15 18.06 260 117839 467797 110003403
Cardiac arrest 70.12 18.06 64 118035 196689 110274511
Cardiac failure congestive 69.85 18.06 37 118062 150963 110320237
Grip strength decreased 69.39 18.06 4 118095 80170 110391030
Stress 69.37 18.06 14 118085 105334 110365866
Heart rate decreased 69.04 18.06 5 118094 82751 110388449
Oedema 68.29 18.06 74 118025 209902 110261298
Thrombocytopenia 68.08 18.06 619 117480 348266 110122934
Device defective 67.10 18.06 45 118054 3777 110467423
Off label use 66.88 18.06 2083 116016 1498102 108973098
Therapeutic procedure 66.72 18.06 29 118070 1011 110470189
Colitis ulcerative 66.53 18.06 4 118095 77359 110393841
Application site discolouration 66.48 18.06 29 118070 1020 110470180
Hepatitis 65.88 18.06 9 118090 90045 110381155
Intentional product misuse 65.36 18.06 30 118069 132874 110338326
Obesity 65.08 18.06 20 118079 113331 110357869
Lower limb fracture 64.48 18.06 4 118095 75344 110395856
Metabolic acidosis 64.14 18.06 14 118085 99730 110371470
Atelectasis 63.88 18.06 129 117970 36583 110434617
Sciatica 63.57 18.06 11 118088 92388 110378812
Frequent bowel movements 63.56 18.06 3 118096 71387 110399813
Platelet count decreased 63.09 18.06 442 117657 230001 110241199
International normalised ratio increased 62.71 18.06 9 118090 86763 110384437
Abdominal pain upper 61.91 18.06 180 117919 348931 110122269
Hallucination 61.76 18.06 16 118083 101416 110369784
Neutropenic colitis 61.24 18.06 58 118041 8007 110463193
Coronary artery disease 60.77 18.06 4 118095 71686 110399514
Rectal haemorrhage 60.58 18.06 26 118073 119807 110351393
Agitation 59.63 18.06 23 118076 113028 110358172
Application site injury 59.14 18.06 12 118087 18 110471182
Sedation 58.74 18.06 4 118095 69679 110401521
Muscular weakness 58.58 18.06 110 117989 248358 110222842
Product quality issue 58.30 18.06 7 118092 77292 110393908
Hypoaesthesia 57.94 18.06 159 117940 314064 110157136
Cardiac failure 57.88 18.06 69 118030 187557 110283643
Therapy non-responder 57.45 18.06 50 118049 157257 110313943
Leukocytosis 57.27 18.06 156 117943 53672 110417528
Insomnia 56.86 18.06 196 117903 360394 110110806
Hypotension 56.53 18.06 328 117771 523521 109947679
Device material issue 56.24 18.06 21 118078 489 110470711
Hypoglycaemia 55.87 18.06 27 118072 116077 110355123
Lactic acidosis 55.82 18.06 15 118084 92796 110378404
Lung disorder 55.77 18.06 66 118033 179981 110291219
Cataract 55.71 18.06 9 118090 79476 110391724
Rhabdomyolysis 54.96 18.06 30 118069 120371 110350829
Blood glucose increased 54.91 18.06 37 118062 132459 110338741
Hyperkalaemia 54.85 18.06 39 118060 135757 110335443
Cardio-respiratory arrest 54.14 18.06 28 118071 115808 110355392
Alopecia areata 54.10 18.06 32 118067 2155 110469045
Depressed level of consciousness 52.69 18.06 27 118072 112251 110358949
Red blood cell sedimentation rate increased 52.41 18.06 10 118089 78292 110392908
Mucosal inflammation 51.16 18.06 221 117878 95920 110375280
Tremor 50.85 18.06 86 118013 202146 110269054
Osteoporosis 50.72 18.06 15 118084 87137 110384063
Wound infection 50.26 18.06 20 118079 96445 110374755
Dyspepsia 50.08 18.06 79 118020 190886 110280314
Oedema peripheral 49.58 18.06 182 117917 328478 110142722
Treatment noncompliance 49.54 18.06 9 118090 72981 110398219
Blood pressure fluctuation 49.14 18.06 10 118089 74814 110396386
Ear infection 49.03 18.06 5 118094 62727 110408473
Prescribed underdose 48.91 18.06 6 118093 65168 110406032
Epilepsy 48.68 18.06 23 118076 100186 110371014
Device monitoring procedure not performed 48.62 18.06 9 118090 5 110471195
COVID-19 48.22 18.06 120 117979 244940 110226260
Inflammation 47.83 18.06 83 118016 193155 110278045
Leukopenia 47.75 18.06 297 117802 148494 110322706
Blood creatinine increased 47.64 18.06 76 118023 182813 110288387
Medication error 47.02 18.06 27 118072 105339 110365861
Application site haematoma 46.99 18.06 12 118087 71 110471129
Autoimmune disorder 46.84 18.06 7 118092 65476 110405724
Gastrointestinal haemorrhage 46.79 18.06 65 118034 165453 110305747
Liver function test increased 46.73 18.06 18 118081 88530 110382670
Expired device used 46.71 18.06 20 118079 672 110470528
Renal failure 46.12 18.06 109 117990 226465 110244735
Aggression 45.56 18.06 5 118094 59205 110411995
Injection site reaction 45.54 18.06 19 118080 89051 110382149
Blood creatine phosphokinase increased 45.51 18.06 11 118088 73066 110398134
Inappropriate schedule of product administration 45.28 18.06 372 117727 203265 110267935
Product storage error 44.74 18.06 82 118017 21646 110449554
Abdominal distension 44.45 18.06 74 118025 175029 110296171
Diabetes mellitus 43.59 18.06 26 118073 99355 110371845
Pancytopenia 42.95 18.06 376 117723 209237 110261963
Application site reaction 42.83 18.06 20 118079 827 110470373
Drug resistance 42.77 18.06 5 118094 56369 110414831
Psychotic disorder 42.71 18.06 3 118096 50934 110420266
Dyspnoea 41.88 18.06 883 117216 1105989 109365211
Abdominal pain 41.63 18.06 349 117750 512640 109958560
Pulmonary fibrosis 41.61 18.06 29 118070 102013 110369187
Drug reaction with eosinophilia and systemic symptoms 41.19 18.06 18 118081 82077 110389123
Hair texture abnormal 41.15 18.06 34 118065 3920 110467280
Upper respiratory tract infection 40.82 18.06 48 118051 131280 110339920
Nail bed inflammation 40.76 18.06 26 118073 2004 110469196
Hepatotoxicity 40.56 18.06 9 118090 63391 110407809
Injection site pruritus 40.29 18.06 4 118095 51254 110419946
Heart rate abnormal 40.26 18.06 44 118055 7194 110464006
Pregnancy 40.10 18.06 4 118095 51063 110420137
Haemorrhage 40.07 18.06 33 118066 106659 110364541
Nasal mucosal disorder 40.02 18.06 25 118074 1858 110469342
Fat embolism syndrome 39.88 18.06 12 118087 139 110471061
Visual impairment 39.81 18.06 51 118048 134377 110336823
Application site pruritus 39.64 18.06 34 118065 4126 110467074
Poor quality device used 39.30 18.06 29 118070 2834 110468366
Pulmonary oedema 39.23 18.06 30 118069 100629 110370571
Vision blurred 39.20 18.06 48 118051 128974 110342226
Carotidynia 38.62 18.06 12 118087 156 110471044
Sleep disorder due to a general medical condition 38.61 18.06 5 118094 52107 110419093
Madarosis 38.61 18.06 31 118068 3432 110467768
Oral pain 38.32 18.06 107 117992 37337 110433863
Hair colour changes 37.99 18.06 35 118064 4666 110466534
Melaena 37.93 18.06 13 118086 68744 110402456
Nasal congestion 37.41 18.06 30 118069 98252 110372948
Basal cell carcinoma 37.01 18.06 3 118096 45267 110425933
Haematemesis 36.60 18.06 9 118090 59099 110412101
Pancreatitis 36.30 18.06 28 118071 93505 110377695
Nephrolithiasis 35.71 18.06 13 118086 66199 110405001
Fluid retention 35.63 18.06 29 118070 94278 110376922
Injection site erythema 35.53 18.06 29 118070 94147 110377053
Influenza 35.49 18.06 80 118019 169021 110302179
Transient ischaemic attack 35.47 18.06 12 118087 63970 110407230
Alanine aminotransferase increased 35.36 18.06 91 118008 183682 110287518
Obstructive airways disorder 35.25 18.06 4 118095 46145 110425055
Incorrect dose administered 35.22 18.06 210 117889 103431 110367769
Imaging procedure 35.06 18.06 6 118093 0 110471200
Vertigo 35.01 18.06 25 118074 86845 110384355
Cardiogenic shock 34.99 18.06 9 118090 57329 110413871
Joint stiffness 34.93 18.06 14 118085 67229 110403971
Serotonin syndrome 34.75 18.06 10 118089 59143 110412057
Generalised tonic-clonic seizure 34.50 18.06 8 118091 54672 110416528
Application site irritation 34.47 18.06 23 118076 1914 110469286
Bone marrow necrosis 34.27 18.06 14 118085 417 110470783
Dysarthria 34.17 18.06 24 118075 84097 110387103
Pneumonia 34.11 18.06 696 117403 876018 109595182
Haematochezia 34.03 18.06 44 118055 115480 110355720
Disturbance in attention 33.72 18.06 12 118087 61983 110409217
Anaemia 33.39 18.06 792 117307 546294 109924906
Lupus-like syndrome 32.54 18.06 3 118096 40789 110430411
Injection site haemorrhage 32.45 18.06 93 118006 32935 110438265
Irritability 32.22 18.06 6 118093 47803 110423397
Tubulointerstitial nephritis 32.22 18.06 9 118090 54275 110416925
Respiratory arrest 32.20 18.06 11 118088 58288 110412912
Unresponsive to stimuli 31.98 18.06 14 118085 63776 110407424
Joint injury 31.75 18.06 3 118096 39991 110431209
White blood cell disorder 31.71 18.06 29 118070 3830 110467370
Angioedema 31.70 18.06 35 118064 98465 110372735
Cholelithiasis 31.67 18.06 14 118085 63408 110407792
Dyskinesia 31.54 18.06 8 118091 51438 110419762
Infection 31.40 18.06 242 117857 361958 110109242
Unevaluable event 31.39 18.06 136 117963 59091 110412109
Hallucination, visual 31.36 18.06 3 118096 39602 110431598
Aphasia 31.12 18.06 12 118087 58985 110412215
Cholestasis 31.04 18.06 15 118084 64503 110406697
Loss of consciousness 30.72 18.06 107 117992 196199 110275001
Chronic obstructive pulmonary disease 30.71 18.06 43 118056 109115 110362085
Peripheral sensory neuropathy 30.69 18.06 60 118039 16620 110454580
Palmar-plantar erythrodysaesthesia syndrome 30.61 18.06 105 117994 40920 110430280
Hyponatraemia 30.57 18.06 124 117975 217529 110253671
Failure to anastomose 30.52 18.06 11 118088 231 110470969
Streptococcal sepsis 30.26 18.06 32 118067 5040 110466160
Product packaging issue 30.12 18.06 20 118079 1651 110469549
Lymphadenitis 29.87 18.06 33 118066 5460 110465740
General physical health deterioration 29.87 18.06 300 117799 424995 110046205
Neutropenic infection 29.87 18.06 26 118073 3219 110467981
Throat irritation 29.76 18.06 10 118089 53542 110417658
Gastrointestinal disorder 29.67 18.06 145 117954 241807 110229393
Accidental underdose 29.45 18.06 18 118081 1287 110469913
Refusal of treatment by patient 29.27 18.06 43 118056 9451 110461749
Rash pruritic 29.25 18.06 37 118062 98032 110373168
Oxygen saturation decreased 29.24 18.06 79 118020 156903 110314297
Scan 29.22 18.06 5 118094 0 110471200
X-ray 29.22 18.06 5 118094 0 110471200
Ultrasound scan 29.22 18.06 5 118094 0 110471200
Illness 28.94 18.06 27 118072 82144 110389056
Body temperature abnormal 28.79 18.06 25 118074 3084 110468116
Injection site swelling 28.78 18.06 15 118084 61775 110409425
Haematuria 28.39 18.06 28 118071 82977 110388223
Palpitations 28.26 18.06 82 118017 159130 110312070
Accidental overdose 28.25 18.06 10 118089 51824 110419376
Nightmare 28.15 18.06 4 118095 38859 110432341
Orthostatic hypotension 28.12 18.06 18 118081 66231 110404969
Disease recurrence 27.95 18.06 15 118084 60769 110410431
Pseudomonal sepsis 27.93 18.06 41 118058 9005 110462195
Product prescribing error 27.81 18.06 10 118089 51321 110419879
Hepatic cytolysis 27.73 18.06 12 118087 55041 110416159
Cardiac disorder 26.94 18.06 25 118074 76255 110394945
Respiratory disorder 26.90 18.06 22 118077 71360 110399840
Dry eye 26.80 18.06 13 118086 55780 110415420
Jaundice 26.68 18.06 15 118084 59221 110411979
Pulmonary hypertension 26.32 18.06 13 118086 55207 110415993
Splenic rupture 26.04 18.06 22 118077 2615 110468585
Pneumonitis 25.96 18.06 155 117944 76376 110394824
Myeloblast count increased 25.92 18.06 7 118092 53 110471147
Bronchiectasis 25.87 18.06 4 118095 36489 110434711
Pain in extremity 25.62 18.06 366 117733 486752 109984448
Rash erythematous 25.33 18.06 30 118069 81802 110389398
Eye irritation 25.30 18.06 3 118096 33449 110437751
Application site laceration 25.28 18.06 5 118094 6 110471194
Femur fracture 25.25 18.06 8 118091 44461 110426739
Metastases to central nervous system 25.14 18.06 67 118032 22750 110448450
Interstitial lung disease 25.02 18.06 243 117856 139091 110332109
Radiotherapy 24.88 18.06 17 118082 1471 110469729
Therapy interrupted 24.87 18.06 11 118088 49811 110421389
Chronic kidney disease 24.67 18.06 27 118072 76264 110394936
Basal ganglion degeneration 24.25 18.06 11 118088 425 110470775
Capillary leak syndrome 24.16 18.06 28 118071 4880 110466320
Vascular fragility 24.09 18.06 9 118090 210 110470990
Acute febrile neutrophilic dermatosis 24.03 18.06 28 118071 4908 110466292
Hepatocellular injury 24.02 18.06 12 118087 50630 110420570
Taste disorder 23.61 18.06 21 118078 65366 110405834
Endoscopic retrograde cholangiopancreatography 23.51 18.06 9 118090 225 110470975
Laryngitis 23.43 18.06 8 118091 42403 110428797
Blood magnesium decreased 23.35 18.06 60 118039 19936 110451264
Uterine enlargement 23.29 18.06 14 118085 971 110470229
Toxic epidermal necrolysis 23.29 18.06 16 118083 56711 110414489
Diabetic ketoacidosis 23.12 18.06 8 118091 42050 110429150
Balance disorder 22.97 18.06 57 118042 116503 110354697
Breast cancer metastatic 22.77 18.06 42 118057 11139 110460061
Heart rate increased 22.77 18.06 78 118021 143756 110327444
Liver function test abnormal 22.74 18.06 24 118075 68926 110402274
Acute myocardial infarction 22.58 18.06 34 118065 83743 110387457
Therapeutic response decreased 22.48 18.06 43 118056 96456 110374744
Night sweats 22.35 18.06 71 118028 133912 110337288
Swollen tongue 22.26 18.06 19 118080 60343 110410857
Therapy cessation 22.24 18.06 10 118089 44847 110426353
Perihepatic abscess 22.15 18.06 8 118091 169 110471031
Blood urea increased 21.90 18.06 16 118083 54941 110416259
Hypervolaemia 21.60 18.06 13 118086 49447 110421753
White blood cell count increased 21.56 18.06 177 117922 96665 110374535
Neck pain 21.43 18.06 64 118035 123066 110348134
Onychomadesis 21.39 18.06 11 118088 45652 110425548
Cystitis haemorrhagic 21.36 18.06 43 118056 12166 110459034
Gastritis bacterial 21.34 18.06 11 118088 565 110470635
Diplopia 21.31 18.06 9 118090 41885 110429315
Tongue coated 21.20 18.06 17 118082 1879 110469321
Tinnitus 21.19 18.06 20 118079 60520 110410680
Intercepted product selection error 21.19 18.06 5 118094 20 110471180
Hyperleukocytosis 21.06 18.06 22 118077 3417 110467783
Atrial fibrillation 21.05 18.06 151 117948 229491 110241709
Vein discolouration 20.90 18.06 10 118089 437 110470763
Gastroenteritis viral 20.87 18.06 4 118095 31222 110439978
Anaesthesia 20.85 18.06 11 118088 593 110470607
Ventricular fibrillation 20.82 18.06 9 118090 41304 110429896
Paraesthesia 20.69 18.06 192 117907 276329 110194871
Eosinophilia 20.45 18.06 19 118080 57917 110413283
Body temperature decreased 20.35 18.06 7 118092 36928 110434272
Premature delivery 20.31 18.06 4 118095 30628 110440572
Pneumocystis jirovecii pneumonia 20.30 18.06 95 118004 42640 110428560
Hepatic encephalopathy 20.25 18.06 3 118096 28253 110442947
Mastectomy 20.06 18.06 15 118084 1496 110469704
Tissue infiltration 20.06 18.06 13 118086 1030 110470170
Acute hepatic failure 19.94 18.06 7 118092 36461 110434739
Injury associated with device 19.89 18.06 24 118075 4365 110466835
Transaminases increased 19.87 18.06 23 118076 63367 110407833
Disorientation 19.72 18.06 28 118071 70643 110400557
Stevens-Johnson syndrome 19.56 18.06 13 118086 46888 110424312
Respiratory depth decreased 19.52 18.06 5 118094 30 110471170
Diabetes mellitus inadequate control 19.51 18.06 4 118095 29771 110441429
Hyperlipidaemia 19.39 18.06 7 118092 35841 110435359
Posterior reversible encephalopathy syndrome 19.39 18.06 6 118093 33855 110437345
Transposition of the great vessels 19.38 18.06 6 118093 77 110471123
Device dislocation 19.32 18.06 76 118023 31628 110439572
Ischaemic stroke 19.24 18.06 10 118089 41253 110429947
Sinus bradycardia 19.24 18.06 4 118095 29479 110441721
Nail bed tenderness 19.21 18.06 9 118090 375 110470825
Angina pectoris 19.11 18.06 23 118076 62272 110408928
Acne 19.08 18.06 6 118093 33514 110437686
Labelled drug-drug interaction medication error 19.07 18.06 4 118095 29298 110441902
Urinary retention 19.06 18.06 28 118071 69655 110401545
Erythema 19.05 18.06 209 117890 291238 110179962
Cytomegalovirus infection 19.04 18.06 18 118081 54426 110416774
Spinal pain 19.04 18.06 53 118046 18462 110452738
Adverse drug reaction 19.00 18.06 54 118045 105505 110365695
Vaginal prolapse 18.99 18.06 9 118090 385 110470815
Infective aortitis 18.97 18.06 6 118093 83 110471117
Cerebral haemorrhage 18.87 18.06 25 118074 64943 110406257
Recall phenomenon 18.85 18.06 14 118085 1382 110469818
Blood potassium increased 18.84 18.06 6 118093 33243 110437957
Vascular device infection 18.72 18.06 49 118050 16463 110454737
Flatulence 18.53 18.06 17 118082 52132 110419068
Movement disorder 18.23 18.06 8 118091 36396 110434804
Eye pain 18.19 18.06 16 118083 50083 110421117
Renal tubular necrosis 18.18 18.06 5 118094 30470 110440730
Haematopoietic stem cell mobilisation 18.18 18.06 9 118090 424 110470776
Application site warmth 18.11 18.06 8 118091 290 110470910

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AA13 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Colony stimulating factors
FDA CS M0024696 Granulocyte Colony-Stimulating Factor
FDA PE N0000009451 Increased Myeloid Cell Production
FDA EPC N0000175666 Leukocyte Growth Factor
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

L03AA Colony stimulating factors 6 drugs
efbemalenograstim alfaeflapegrastimfilgrastimlenograstimlipegfilgrastimsargramostim

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chemotherapy-induced neutropenia indication 425229001
Allogeneic peripheral blood stem cell transplant indication 425843001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Granulocyte colony-stimulating factor receptor Membrane receptor ACTIVATOR DRUG LABEL DRUG LABEL

External reference:

IDSource
3A58010674 UNII
D06889 KEGG_DRUG
4021293 VUID
N0000148730 NUI
4021293 VANDF
4037680 VANDF
C1136535 UMLSCUI
CHEBI:749426 CHEBI
CHEMBL1201568 ChEMBL_ID
DB00019 DRUGBANK_ID
8114 INN_ID
C455861 MESH_SUPPLEMENTAL_RECORD_UI
6969 IUPHAR_LIGAND_ID
2048018 RXNORM
16343 MMSL
284537 MMSL
34517 MMSL
42757 MMSL
d04790 MMSL
009564 NDDF
017594 NDDF
385544005 SNOMEDCT_US
388379009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NYVEPRIA HUMAN PRESCRIPTION DRUG LABEL 1 0069-0324 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 30 sections
Neulasta HUMAN PRESCRIPTION DRUG LABEL 1 55513-099 SOLUTION 4 mg SUBCUTANEOUS BLA 31 sections
Neulasta HUMAN PRESCRIPTION DRUG LABEL 1 55513-190 INJECTION 6 mg SUBCUTANEOUS BLA 31 sections
ZIEXTENZO HUMAN PRESCRIPTION DRUG LABEL 1 61314-866 INJECTION 6 mg SUBCUTANEOUS BLA 25 sections
STIMUFEND HUMAN PRESCRIPTION DRUG LABEL 1 65219-371 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 28 sections
UDENYCA HUMAN PRESCRIPTION DRUG LABEL 1 69448-025 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 26 sections
UDENYCA HUMAN PRESCRIPTION DRUG LABEL 1 69448-026 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 26 sections
UDENYCA HUMAN PRESCRIPTION DRUG LABEL 1 69448-027 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 26 sections
UDENYCA HUMAN PRESCRIPTION DRUG LABEL 1 70114-101 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 26 sections
UDENYCA HUMAN PRESCRIPTION DRUG LABEL 1 70114-120 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 26 sections
UDENYCA HUMAN PRESCRIPTION DRUG LABEL 1 70114-130 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 26 sections
FYLNETRA HUMAN PRESCRIPTION DRUG LABEL 1 70121-1627 INJECTION 6 mg SUBCUTANEOUS BLA 27 sections
ARMLUPEG HUMAN PRESCRIPTION DRUG LABEL 1 70748-273 INJECTION 6 mg SUBCUTANEOUS BLA 25 sections
STIMUFEND HUMAN PRESCRIPTION DRUG LABEL 1 72603-402 INJECTION, SOLUTION 6 mg SUBCUTANEOUS BLA 28 sections
Fulphila HUMAN PRESCRIPTION DRUG LABEL 1 83257-005 INJECTION 6 mg SUBCUTANEOUS BLA 26 sections