All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ibritumomab tiuxetan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
chelating agents	4984	206181-63-7

Description:

Molecule	Description
Synonyms: ibritumomab tiuxetan (90Y) ibritumomab tiuxetan zevalin IDEC-Y2B8	90Y-labeled anti-CD20 monoclonal antibody for radioimmunotherapy for patients with relapsed B-cell non-Hodgkin's lymphoma Molecular weight: 660.50 Formula: C23H32N5O10SY CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Feb. 19, 2002	FDA	SPECTRUM PHARMS
Jan. 16, 2004	EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Thrombocytopenia	111.90	37.66	54	1112	208671	90418610
Bone marrow failure	103.57	37.66	31	1135	32190	90595091
Progressive multifocal leukoencephalopathy	86.40	37.66	23	1143	15632	90611649
Myelodysplastic syndrome	75.37	37.66	22	1144	20881	90606400
Stem cell transplant	67.06	37.66	13	1153	2141	90625140
Neutropenia	58.13	37.66	36	1130	224868	90402413
Pancytopenia	46.35	37.66	25	1141	120238	90507043
Enterococcal infection	42.63	37.66	12	1154	9979	90617302
Platelet count decreased	40.65	37.66	24	1142	136945	90490336

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myelodysplastic syndrome	96.15	33.17	35	1567	22710	42597023
Meningitis tuberculous	74.39	33.17	14	1588	665	42619068
Thrombocytopenia	67.15	33.17	56	1546	190223	42429510
Mucosal inflammation	64.14	33.17	33	1569	49341	42570392
Acute myeloid leukaemia	57.56	33.17	24	1578	22232	42597501
Venoocclusive liver disease	51.59	33.17	18	1584	10284	42609449
Bone marrow failure	45.49	33.17	23	1579	33070	42586663
Second primary malignancy	45.15	33.17	16	1586	9559	42610174
Neutropenia	40.01	33.17	43	1559	199388	42420345
Hepatic angiosarcoma	39.46	33.17	6	1596	76	42619657
Febrile neutropenia	38.94	33.17	41	1561	185662	42434071
Progressive multifocal leukoencephalopathy	38.66	33.17	15	1587	11521	42608212
Herpes simplex	37.84	33.17	13	1589	7082	42612651
Stem cell transplant	36.14	33.17	10	1592	2662	42617071
White blood cell count decreased	33.71	33.17	30	1572	110366	42509367

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myelodysplastic syndrome	146.22	34.22	49	2717	37435	110549098
Bone marrow failure	125.46	34.22	49	2717	57799	110528734
Thrombocytopenia	122.91	34.22	87	2679	348798	110237735
Progressive multifocal leukoencephalopathy	102.75	34.22	34	2732	24922	110561611
Stem cell transplant	89.34	34.22	21	2745	4406	110582127
Neutropenia	80.81	34.22	70	2696	374550	110211983
Platelet count decreased	70.76	34.22	53	2713	230390	110356143
Cytomegalovirus infection	70.56	34.22	32	2734	54412	110532121
Pancytopenia	68.37	34.22	50	2716	209563	110376970
Acute myeloid leukaemia	67.73	34.22	28	2738	38082	110548451
Meningitis tuberculous	65.17	34.22	13	2753	1265	110585268
White blood cell count decreased	64.35	34.22	50	2716	229340	110357193
Acute graft versus host disease in intestine	59.89	34.22	16	2750	5623	110580910
Multiple organ dysfunction syndrome	53.56	34.22	38	2728	151672	110434861
Disease progression	51.28	34.22	45	2721	243989	110342544
Acute graft versus host disease in skin	49.71	34.22	16	2750	10724	110575809
Venoocclusive liver disease	48.03	34.22	17	2749	15190	110571343
Respiratory failure	47.84	34.22	41	2725	215291	110371242
Second primary malignancy	45.17	34.22	17	2749	18051	110568482
Aplasia	41.70	34.22	13	2753	7860	110578673
Mucosal inflammation	40.81	34.22	27	2739	96114	110490419
Hepatic angiosarcoma	39.82	34.22	6	2760	110	110586423
Sepsis	38.41	34.22	44	2722	327302	110259231
Herpes simplex	36.40	34.22	14	2752	15750	110570783
Enterococcal infection	36.29	34.22	15	2751	20351	110566182
Neutrophil count decreased	35.23	34.22	27	2739	120914	110465619

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V10XX02	VARIOUS THERAPEUTIC RADIOPHARMACEUTICALS OTHER THERAPEUTIC RADIOPHARMACEUTICALS Various therapeutic radiopharmaceuticals
FDA MoA	N0000000205	Radiopharmaceutical Activity
FDA MoA	N0000175078	CD20-directed Antibody Interactions
FDA EPC	N0000175658	CD20-directed Radiotherapeutic Antibody
CHEBI has role	CHEBI:35610	antineoplastic agent

Related Drugs by ATC class:

V10XX Various therapeutic radiopharmaceuticals 4 drugs

lutetium (177Lu) oxodotreotidelutetium (177Lu) vipivotide tetraxetanradium Ra 223 dichloridesodium phosphate (32P)

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Follicular non-Hodgkin's lymphoma	indication	308121000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
B-lymphocyte antigen CD20	Surface antigen	P11836	CD20_HUMAN	ANTIBODY BINDING	Kd	7.85		DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D04489	KEGG_DRUG
4021301	VUID
N0000148737	NUI
4021301	VANDF
CHEBI:749464	CHEBI
CHEMBL1201606	ChEMBL_ID
C422802	MESH_SUPPLEMENTAL_RECORD_UI
6777	IUPHAR_LIGAND_ID
DB00078	DRUGBANK_ID
262323	RXNORM
17128	MMSL
d04845	MMSL
009576	NDDF
385546007	SNOMEDCT_US
385548008	SNOMEDCT_US
C0877880	UMLSCUI
CHEMBL2108667	ChEMBL_ID
7873	INN_ID
4Q52C550XK	UNII

Pharmaceutical products:

None