Stem definition | Drug id | CAS RN |
---|---|---|
humanized origin | 4979 | 180288-69-1 |
Molecule | Description |
---|---|
Synonyms:
|
The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Trastuzumab products have been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2. Trastuzumab products are mediators of antibody-dependent cellular cytotoxicity (ADCC). In vitro, trastuzumab product-mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.
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Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 28, 2000 | EMA | ROCHE REGISTRATION GMBH | |
Sept. 25, 1998 | FDA | GENENTECH | |
April 4, 2001 | PMDA | ROCHE JAPAN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ejection fraction decreased | 2737.29 | 13.24 | 1134 | 108980 | 18707 | 56163246 |
Disease progression | 1559.05 | 13.24 | 1432 | 108682 | 103741 | 56078212 |
Myelosuppression | 1471.73 | 13.24 | 707 | 109407 | 16748 | 56165205 |
Metastases to central nervous system | 1353.43 | 13.24 | 597 | 109517 | 11539 | 56170414 |
Diarrhoea | 1145.08 | 13.24 | 3270 | 106844 | 635237 | 55546716 |
Palmar-plantar erythrodysaesthesia syndrome | 1130.88 | 13.24 | 630 | 109484 | 20435 | 56161518 |
Cardiotoxicity | 1043.20 | 13.24 | 434 | 109680 | 7216 | 56174737 |
Neuropathy peripheral | 852.77 | 13.24 | 1028 | 109086 | 101865 | 56080088 |
Febrile neutropenia | 747.68 | 13.24 | 975 | 109139 | 104570 | 56077383 |
Drug ineffective | 685.18 | 13.24 | 485 | 109629 | 918504 | 55263449 |
Rheumatoid arthritis | 654.79 | 13.24 | 21 | 110093 | 382583 | 55799370 |
Neutropenia | 634.53 | 13.24 | 1121 | 108993 | 157046 | 56024907 |
Bone marrow failure | 547.10 | 13.24 | 449 | 109665 | 27837 | 56154116 |
Metastases to bone | 509.20 | 13.24 | 370 | 109744 | 19138 | 56162815 |
Mucosal inflammation | 465.48 | 13.24 | 493 | 109621 | 42317 | 56139636 |
Metastases to liver | 464.96 | 13.24 | 365 | 109749 | 21221 | 56160732 |
Chills | 430.21 | 13.24 | 742 | 109372 | 101862 | 56080091 |
Breast cancer metastatic | 425.69 | 13.24 | 303 | 109811 | 15166 | 56166787 |
Cardiac dysfunction | 414.22 | 13.24 | 153 | 109961 | 1817 | 56180136 |
Metastases to lung | 406.81 | 13.24 | 265 | 109849 | 11453 | 56170500 |
Polyneuropathy | 395.00 | 13.24 | 271 | 109843 | 12779 | 56169174 |
Left ventricular dysfunction | 365.36 | 13.24 | 243 | 109871 | 10880 | 56171073 |
Breast cancer recurrent | 337.00 | 13.24 | 163 | 109951 | 3912 | 56178041 |
Interstitial lung disease | 325.12 | 13.24 | 475 | 109639 | 56588 | 56125365 |
Joint swelling | 323.56 | 13.24 | 84 | 110030 | 289716 | 55892237 |
Malignant neoplasm progression | 318.61 | 13.24 | 540 | 109574 | 73047 | 56108906 |
Metastases to lymph nodes | 313.24 | 13.24 | 190 | 109924 | 7233 | 56174720 |
Drug hypersensitivity | 312.56 | 13.24 | 77 | 110037 | 275128 | 55906825 |
Cardiac failure | 303.33 | 13.24 | 562 | 109552 | 81531 | 56100422 |
Synovitis | 294.50 | 13.24 | 4 | 110110 | 161301 | 56020652 |
Systemic lupus erythematosus | 287.30 | 13.24 | 16 | 110098 | 180062 | 56001891 |
Condition aggravated | 261.96 | 13.24 | 177 | 109937 | 344721 | 55837232 |
Cardiomyopathy | 261.01 | 13.24 | 232 | 109882 | 16026 | 56165927 |
Therapeutic product effect decreased | 258.59 | 13.24 | 19 | 110095 | 169433 | 56012520 |
Arthropathy | 249.93 | 13.24 | 45 | 110069 | 200230 | 55981723 |
Completed suicide | 245.69 | 13.24 | 3 | 110111 | 133830 | 56048123 |
Peripheral sensory neuropathy | 243.12 | 13.24 | 158 | 109956 | 6798 | 56175155 |
Fall | 241.44 | 13.24 | 207 | 109907 | 357303 | 55824650 |
Death | 231.52 | 13.24 | 1294 | 108820 | 340132 | 55841821 |
Abdominal discomfort | 223.20 | 13.24 | 133 | 109981 | 277141 | 55904812 |
Metastasis | 218.86 | 13.24 | 129 | 109985 | 4655 | 56177298 |
Pleural effusion | 213.20 | 13.24 | 498 | 109616 | 84982 | 56096971 |
Skin toxicity | 205.93 | 13.24 | 118 | 109996 | 4035 | 56177918 |
Sinusitis | 195.64 | 13.24 | 71 | 110043 | 197510 | 55984443 |
Lymphoedema | 190.74 | 13.24 | 161 | 109953 | 10369 | 56171584 |
Neoplasm progression | 182.98 | 13.24 | 267 | 109847 | 31749 | 56150204 |
Metastases to skin | 182.96 | 13.24 | 78 | 110036 | 1380 | 56180573 |
Pneumonitis | 181.51 | 13.24 | 264 | 109850 | 31300 | 56150653 |
Treatment failure | 181.38 | 13.24 | 54 | 110060 | 170338 | 56011615 |
Neutropenic sepsis | 181.37 | 13.24 | 184 | 109930 | 15001 | 56166952 |
Neurotoxicity | 178.89 | 13.24 | 186 | 109928 | 15609 | 56166344 |
Epistaxis | 178.74 | 13.24 | 401 | 109713 | 66622 | 56115331 |
Breast cancer | 177.37 | 13.24 | 332 | 109782 | 48501 | 56133452 |
Nail disorder | 167.31 | 13.24 | 155 | 109959 | 11296 | 56170657 |
Drug interaction | 165.37 | 13.24 | 103 | 110011 | 209652 | 55972301 |
Glossodynia | 164.67 | 13.24 | 47 | 110067 | 152411 | 56029542 |
Onycholysis | 160.41 | 13.24 | 70 | 110044 | 1314 | 56180639 |
Product dose omission issue | 159.41 | 13.24 | 102 | 110012 | 204651 | 55977302 |
Pyrexia | 150.99 | 13.24 | 1362 | 108752 | 417411 | 55764542 |
Swelling | 141.74 | 13.24 | 156 | 109958 | 239615 | 55942338 |
Weight increased | 140.75 | 13.24 | 145 | 109969 | 229558 | 55952395 |
Psoriasis | 139.62 | 13.24 | 11 | 110103 | 92681 | 56089272 |
Pain | 139.35 | 13.24 | 747 | 109367 | 662437 | 55519516 |
Osteonecrosis of jaw | 139.27 | 13.24 | 241 | 109873 | 33117 | 56148836 |
Drug intolerance | 137.94 | 13.24 | 190 | 109924 | 264628 | 55917325 |
Computerised tomogram thorax abnormal | 137.26 | 13.24 | 64 | 110050 | 1411 | 56180542 |
Product use issue | 129.96 | 13.24 | 104 | 110010 | 185937 | 55996016 |
Onychoclasis | 127.96 | 13.24 | 98 | 110016 | 5487 | 56176466 |
Bone pain | 127.93 | 13.24 | 295 | 109819 | 49890 | 56132063 |
Hypokalaemia | 127.77 | 13.24 | 441 | 109673 | 93996 | 56087957 |
Decreased appetite | 127.66 | 13.24 | 799 | 109315 | 218432 | 55963521 |
Wound | 125.75 | 13.24 | 57 | 110057 | 138747 | 56043206 |
Maternal exposure during pregnancy | 125.01 | 13.24 | 112 | 110002 | 189441 | 55992512 |
Nausea | 124.94 | 13.24 | 2141 | 107973 | 762037 | 55419916 |
Ventricular hypokinesia | 124.18 | 13.24 | 86 | 110028 | 4115 | 56177838 |
Confusional state | 122.38 | 13.24 | 136 | 109978 | 208019 | 55973934 |
Stomatitis | 119.74 | 13.24 | 511 | 109603 | 120299 | 56061654 |
Haematotoxicity | 119.63 | 13.24 | 112 | 110002 | 8271 | 56173682 |
Drug abuse | 117.97 | 13.24 | 3 | 110111 | 67607 | 56114346 |
Vomiting | 117.48 | 13.24 | 1488 | 108626 | 496740 | 55685213 |
Nail discolouration | 116.00 | 13.24 | 68 | 110046 | 2428 | 56179525 |
Nail toxicity | 115.75 | 13.24 | 38 | 110076 | 308 | 56181645 |
Pericardial effusion | 113.00 | 13.24 | 196 | 109918 | 26979 | 56154974 |
Therapeutic product effect incomplete | 112.06 | 13.24 | 34 | 110080 | 105997 | 56075956 |
Loss of personal independence in daily activities | 106.50 | 13.24 | 16 | 110098 | 81353 | 56100600 |
Lacrimation increased | 106.25 | 13.24 | 154 | 109960 | 18194 | 56163759 |
Somnolence | 106.02 | 13.24 | 98 | 110016 | 163315 | 56018638 |
Toxicity to various agents | 105.39 | 13.24 | 173 | 109941 | 224391 | 55957562 |
Gastrointestinal toxicity | 105.12 | 13.24 | 91 | 110023 | 6065 | 56175888 |
Acute myeloid leukaemia | 104.98 | 13.24 | 147 | 109967 | 16825 | 56165128 |
Mitral valve incompetence | 104.59 | 13.24 | 152 | 109962 | 18001 | 56163952 |
Alveolitis | 104.06 | 13.24 | 65 | 110049 | 2608 | 56179345 |
Metastatic neoplasm | 103.84 | 13.24 | 75 | 110039 | 3838 | 56178115 |
Hospitalisation | 102.29 | 13.24 | 13 | 110101 | 74987 | 56106966 |
Musculoskeletal stiffness | 101.87 | 13.24 | 93 | 110021 | 155914 | 56026039 |
Injection site pain | 101.62 | 13.24 | 51 | 110063 | 117067 | 56064886 |
Overdose | 101.39 | 13.24 | 40 | 110074 | 105790 | 56076163 |
Neutrophil count decreased | 98.67 | 13.24 | 266 | 109848 | 49556 | 56132397 |
Biopsy lung abnormal | 97.80 | 13.24 | 28 | 110086 | 134 | 56181819 |
Thrombocytopenia | 97.80 | 13.24 | 525 | 109589 | 135699 | 56046254 |
Dyspnoea | 97.19 | 13.24 | 1662 | 108452 | 590915 | 55591038 |
Fibromyalgia | 95.90 | 13.24 | 5 | 110109 | 59598 | 56122355 |
Exposure during pregnancy | 95.46 | 13.24 | 76 | 110038 | 136266 | 56045687 |
Duodenal ulcer perforation | 95.28 | 13.24 | 11 | 110103 | 68331 | 56113622 |
Neutropenic infection | 93.40 | 13.24 | 45 | 110069 | 1070 | 56180883 |
Cellulitis | 92.78 | 13.24 | 340 | 109774 | 74609 | 56107344 |
Hepatic enzyme increased | 92.17 | 13.24 | 120 | 109994 | 171264 | 56010689 |
Hyperpyrexia | 92.16 | 13.24 | 65 | 110049 | 3203 | 56178750 |
Asthenia | 90.08 | 13.24 | 1046 | 109068 | 341927 | 55840026 |
Dysgeusia | 89.78 | 13.24 | 227 | 109887 | 40688 | 56141265 |
Colitis | 89.70 | 13.24 | 230 | 109884 | 41581 | 56140372 |
Leukopenia | 89.66 | 13.24 | 324 | 109790 | 70616 | 56111337 |
Onychomadesis | 89.25 | 13.24 | 74 | 110040 | 4647 | 56177306 |
Radiation necrosis | 88.41 | 13.24 | 32 | 110082 | 357 | 56181596 |
Dry skin | 87.81 | 13.24 | 246 | 109868 | 46863 | 56135090 |
Discomfort | 87.32 | 13.24 | 89 | 110025 | 141672 | 56040281 |
Erysipelas | 87.22 | 13.24 | 88 | 110026 | 7125 | 56174828 |
Inappropriate schedule of product administration | 85.86 | 13.24 | 28 | 110086 | 83359 | 56098594 |
Lymphangiosis carcinomatosa | 85.65 | 13.24 | 44 | 110070 | 1205 | 56180748 |
Paronychia | 84.58 | 13.24 | 73 | 110041 | 4845 | 56177108 |
HER2 positive breast cancer | 83.62 | 13.24 | 31 | 110083 | 372 | 56181581 |
Metastases to spine | 83.25 | 13.24 | 59 | 110055 | 2930 | 56179023 |
Breast pain | 83.18 | 13.24 | 90 | 110024 | 7904 | 56174049 |
Recall phenomenon | 82.74 | 13.24 | 34 | 110080 | 546 | 56181407 |
Vascular device infection | 82.30 | 13.24 | 76 | 110038 | 5514 | 56176439 |
Contusion | 82.13 | 13.24 | 78 | 110036 | 128352 | 56053601 |
Anaemia | 81.77 | 13.24 | 841 | 109273 | 266670 | 55915283 |
Mobility decreased | 81.62 | 13.24 | 46 | 110068 | 98945 | 56083008 |
Nail dystrophy | 81.50 | 13.24 | 39 | 110075 | 913 | 56181040 |
Disease recurrence | 81.40 | 13.24 | 158 | 109956 | 23702 | 56158251 |
Dermatitis acneiform | 79.86 | 13.24 | 67 | 110047 | 4277 | 56177676 |
Organising pneumonia | 79.45 | 13.24 | 73 | 110041 | 5262 | 56176691 |
Hypertransaminasaemia | 79.20 | 13.24 | 69 | 110045 | 4638 | 56177315 |
Suicide attempt | 78.92 | 13.24 | 10 | 110104 | 57826 | 56124127 |
Invasive ductal breast carcinoma | 78.40 | 13.24 | 81 | 110033 | 6745 | 56175208 |
Injection site erythema | 78 | 13.24 | 27 | 110087 | 77421 | 56104532 |
Asthma | 77.51 | 13.24 | 64 | 110050 | 112706 | 56069247 |
Arthritis | 77.29 | 13.24 | 50 | 110064 | 99802 | 56082151 |
Blood cholesterol increased | 77.17 | 13.24 | 23 | 110091 | 72556 | 56109397 |
Lung infiltration | 76.20 | 13.24 | 113 | 110001 | 13625 | 56168328 |
Osteonecrosis | 75.89 | 13.24 | 151 | 109963 | 23064 | 56158889 |
Radiation skin injury | 75.22 | 13.24 | 36 | 110078 | 843 | 56181110 |
Irritable bowel syndrome | 72.23 | 13.24 | 22 | 110092 | 68436 | 56113517 |
Hot flush | 70.98 | 13.24 | 227 | 109887 | 46499 | 56135454 |
Hepatic function abnormal | 70.94 | 13.24 | 187 | 109927 | 34371 | 56147582 |
Aortitis | 69.94 | 13.24 | 36 | 110078 | 990 | 56180963 |
Constipation | 68.54 | 13.24 | 649 | 109465 | 201294 | 55980659 |
Osteoarthritis | 68.10 | 13.24 | 36 | 110078 | 80260 | 56101693 |
Product use in unapproved indication | 67.41 | 13.24 | 107 | 110007 | 140715 | 56041238 |
Plasma cell myeloma | 66.30 | 13.24 | 7 | 110107 | 46639 | 56135314 |
Multifocal micronodular pneumocyte hyperplasia | 65.27 | 13.24 | 18 | 110096 | 73 | 56181880 |
Bronchial polyp | 65.27 | 13.24 | 18 | 110096 | 73 | 56181880 |
Pericarditis | 65.24 | 13.24 | 70 | 110044 | 108853 | 56073100 |
Onychalgia | 64.34 | 13.24 | 32 | 110082 | 817 | 56181136 |
Injury | 63.57 | 13.24 | 19 | 110095 | 59832 | 56122121 |
Granulocyte count decreased | 63.57 | 13.24 | 33 | 110081 | 924 | 56181029 |
Dehydration | 63.44 | 13.24 | 529 | 109585 | 158296 | 56023657 |
Injection site swelling | 63.35 | 13.24 | 6 | 110108 | 43572 | 56138381 |
Myalgia | 62.83 | 13.24 | 458 | 109656 | 131567 | 56050386 |
Injection site bruising | 62.71 | 13.24 | 3 | 110111 | 38518 | 56143435 |
Recurrent cancer | 62.60 | 13.24 | 41 | 110073 | 1787 | 56180166 |
Cough | 62.54 | 13.24 | 780 | 109334 | 259181 | 55922772 |
Alanine aminotransferase increased | 62.51 | 13.24 | 354 | 109760 | 93308 | 56088645 |
Fatigue | 62.42 | 13.24 | 1998 | 108116 | 786554 | 55395399 |
Madarosis | 62.40 | 13.24 | 48 | 110066 | 2705 | 56179248 |
Migraine | 61.21 | 13.24 | 48 | 110066 | 86749 | 56095204 |
Injection site pruritus | 60.36 | 13.24 | 6 | 110108 | 41925 | 56140028 |
Breast neoplasm | 60.06 | 13.24 | 36 | 110078 | 1340 | 56180613 |
Oligohydramnios | 59.78 | 13.24 | 66 | 110048 | 5928 | 56176025 |
Acute interstitial pneumonitis | 59.24 | 13.24 | 28 | 110086 | 637 | 56181316 |
Systolic dysfunction | 59.04 | 13.24 | 37 | 110077 | 1493 | 56180460 |
Blood lactate dehydrogenase increased | 58.80 | 13.24 | 127 | 109987 | 20548 | 56161405 |
Device related infection | 57.26 | 13.24 | 130 | 109984 | 21750 | 56160203 |
Chest discomfort | 56.61 | 13.24 | 359 | 109755 | 98498 | 56083455 |
Ejection fraction abnormal | 56.54 | 13.24 | 32 | 110082 | 1068 | 56180885 |
White blood cell count decreased | 55.95 | 13.24 | 430 | 109684 | 125560 | 56056393 |
Erythema | 55.31 | 13.24 | 506 | 109608 | 155433 | 56026520 |
Mastitis | 54.95 | 13.24 | 43 | 110071 | 2485 | 56179468 |
Mastectomy | 54.07 | 13.24 | 35 | 110079 | 1495 | 56180458 |
Second primary malignancy | 53.23 | 13.24 | 69 | 110045 | 7333 | 56174620 |
Adverse event | 52.90 | 13.24 | 21 | 110093 | 55355 | 56126598 |
Injection site reaction | 52.86 | 13.24 | 19 | 110095 | 53228 | 56128725 |
Radiation pneumonitis | 52.47 | 13.24 | 34 | 110080 | 1455 | 56180498 |
Atelectasis | 51.96 | 13.24 | 116 | 109998 | 19192 | 56162761 |
Blister | 51.85 | 13.24 | 83 | 110031 | 108804 | 56073149 |
Arthralgia | 51.21 | 13.24 | 683 | 109431 | 500986 | 55680967 |
Congestive cardiomyopathy | 51.13 | 13.24 | 60 | 110054 | 5759 | 56176194 |
Pulmonary embolism | 50.60 | 13.24 | 371 | 109743 | 106753 | 56075200 |
Alopecia areata | 50.47 | 13.24 | 33 | 110081 | 1434 | 56180519 |
Feeling abnormal | 50.41 | 13.24 | 117 | 109997 | 133485 | 56048468 |
Axillary pain | 50.25 | 13.24 | 35 | 110079 | 1690 | 56180263 |
Metastases to meninges | 50.19 | 13.24 | 39 | 110075 | 2231 | 56179722 |
Paraesthesia | 50.14 | 13.24 | 431 | 109683 | 130083 | 56051870 |
Sedation | 50.13 | 13.24 | 5 | 110109 | 34849 | 56147104 |
Blood bilirubin increased | 49.71 | 13.24 | 161 | 109953 | 33193 | 56148760 |
Hyperkalaemia | 49.07 | 13.24 | 19 | 110095 | 50846 | 56131107 |
Nail infection | 48.95 | 13.24 | 39 | 110075 | 2314 | 56179639 |
Urticaria | 48.92 | 13.24 | 134 | 109980 | 144542 | 56037411 |
Platelet count decreased | 48.86 | 13.24 | 366 | 109748 | 106017 | 56075936 |
Incorrect dose administered | 48.47 | 13.24 | 21 | 110093 | 52526 | 56129427 |
Tumour marker increased | 47.61 | 13.24 | 50 | 110064 | 4243 | 56177710 |
Blood uric acid decreased | 47.36 | 13.24 | 25 | 110089 | 725 | 56181228 |
Drug reaction with eosinophilia and systemic symptoms | 47.34 | 13.24 | 3 | 110111 | 30301 | 56151652 |
Impaired healing | 46.45 | 13.24 | 61 | 110053 | 86780 | 56095173 |
Lactic acidosis | 46.13 | 13.24 | 7 | 110107 | 35339 | 56146614 |
Peripheral swelling | 45.96 | 13.24 | 270 | 109844 | 234456 | 55947497 |
Dermatitis | 45.29 | 13.24 | 95 | 110019 | 15062 | 56166891 |
Aspartate aminotransferase increased | 44.85 | 13.24 | 296 | 109818 | 82306 | 56099647 |
Hyperbilirubinaemia | 44.09 | 13.24 | 75 | 110039 | 10160 | 56171793 |
Transaminases increased | 43.90 | 13.24 | 140 | 109974 | 28630 | 56153323 |
Agranulocytosis | 43.87 | 13.24 | 120 | 109994 | 22539 | 56159414 |
Wheezing | 42.96 | 13.24 | 50 | 110064 | 74976 | 56106977 |
Nasal congestion | 42.56 | 13.24 | 29 | 110085 | 56341 | 56125612 |
Suicidal ideation | 41.90 | 13.24 | 31 | 110083 | 57711 | 56124242 |
Hallucination | 41.72 | 13.24 | 22 | 110092 | 49127 | 56132826 |
Dyspnoea exertional | 41.41 | 13.24 | 214 | 109900 | 54475 | 56127478 |
Ear infection | 41.30 | 13.24 | 6 | 110108 | 31289 | 56150664 |
Intentional product misuse | 40.93 | 13.24 | 25 | 110089 | 51479 | 56130474 |
Ascites | 40.43 | 13.24 | 163 | 109951 | 37381 | 56144572 |
Osteoporosis | 40.35 | 13.24 | 26 | 110088 | 52026 | 56129927 |
Depression | 40.33 | 13.24 | 198 | 109916 | 179919 | 56002034 |
Gait disturbance | 39.85 | 13.24 | 174 | 109940 | 163147 | 56018806 |
Peripheral motor neuropathy | 39.55 | 13.24 | 29 | 110085 | 1519 | 56180434 |
Bronchitis | 39.50 | 13.24 | 102 | 110012 | 112209 | 56069744 |
Acute respiratory distress syndrome | 39.38 | 13.24 | 113 | 110001 | 21813 | 56160140 |
Therapy cessation | 38.98 | 13.24 | 4 | 110110 | 27260 | 56154693 |
Tachycardia | 38.76 | 13.24 | 346 | 109768 | 105530 | 56076423 |
Tonsillar disorder | 38.68 | 13.24 | 25 | 110089 | 1065 | 56180888 |
Chronic kidney disease | 38.48 | 13.24 | 17 | 110097 | 42039 | 56139914 |
Skin fissures | 38.43 | 13.24 | 68 | 110046 | 9505 | 56172448 |
Hepatotoxicity | 38.25 | 13.24 | 141 | 109973 | 31012 | 56150941 |
Hair colour changes | 38.12 | 13.24 | 37 | 110077 | 2858 | 56179095 |
Computerised tomogram thorax | 37.80 | 13.24 | 15 | 110099 | 219 | 56181734 |
Metastases to chest wall | 37.74 | 13.24 | 19 | 110095 | 498 | 56181455 |
Neoplasm | 37.45 | 13.24 | 54 | 110060 | 6347 | 56175606 |
Neoplasm recurrence | 37.25 | 13.24 | 34 | 110080 | 2430 | 56179523 |
Meibomian gland dysfunction | 37.01 | 13.24 | 13 | 110101 | 132 | 56181821 |
Ejection fraction | 36.91 | 13.24 | 29 | 110085 | 1686 | 56180267 |
Pseudocirrhosis | 36.65 | 13.24 | 20 | 110094 | 621 | 56181332 |
Enterocolitis infectious | 36.60 | 13.24 | 28 | 110086 | 1565 | 56180388 |
Ventricular dysfunction | 36.49 | 13.24 | 35 | 110079 | 2664 | 56179289 |
Anxiety | 36.32 | 13.24 | 225 | 109889 | 192947 | 55989006 |
Influenza | 36.27 | 13.24 | 83 | 110031 | 95178 | 56086775 |
Dermatomyositis | 36.23 | 13.24 | 35 | 110079 | 2687 | 56179266 |
Cystitis noninfective | 36.20 | 13.24 | 23 | 110091 | 951 | 56181002 |
Hyperfibrinogenaemia | 36.06 | 13.24 | 9 | 110105 | 22 | 56181931 |
Troponin I increased | 36.01 | 13.24 | 31 | 110083 | 2050 | 56179903 |
Skin exfoliation | 35.67 | 13.24 | 155 | 109959 | 36745 | 56145208 |
Performance status decreased | 35.60 | 13.24 | 38 | 110076 | 3285 | 56178668 |
International normalised ratio increased | 35.53 | 13.24 | 21 | 110093 | 44020 | 56137933 |
Foot deformity | 35.38 | 13.24 | 3 | 110111 | 23822 | 56158131 |
Wrong technique in product usage process | 35.25 | 13.24 | 37 | 110077 | 58131 | 56123822 |
Breast mass | 35.06 | 13.24 | 55 | 110059 | 6964 | 56174989 |
Tumour pain | 34.84 | 13.24 | 25 | 110089 | 1266 | 56180687 |
Enterocolitis | 34.57 | 13.24 | 55 | 110059 | 7049 | 56174904 |
Sleep apnoea syndrome | 34.38 | 13.24 | 5 | 110109 | 26056 | 56155897 |
Pulmonary mass | 34.38 | 13.24 | 103 | 110011 | 20367 | 56161586 |
Carcinoembryonic antigen increased | 34.14 | 13.24 | 27 | 110087 | 1585 | 56180368 |
Cataract | 34.08 | 13.24 | 30 | 110084 | 51217 | 56130736 |
Jaw operation | 34.04 | 13.24 | 21 | 110093 | 824 | 56181129 |
Toxic cardiomyopathy | 33.98 | 13.24 | 12 | 110102 | 124 | 56181829 |
Coma | 33.89 | 13.24 | 40 | 110074 | 59615 | 56122338 |
Breast inflammation | 33.89 | 13.24 | 12 | 110102 | 125 | 56181828 |
Blood creatinine decreased | 33.83 | 13.24 | 46 | 110068 | 5120 | 56176833 |
Foetal exposure during pregnancy | 33.69 | 13.24 | 12 | 110102 | 33811 | 56148142 |
Adverse drug reaction | 33.57 | 13.24 | 47 | 110067 | 65085 | 56116868 |
Cardiac failure congestive | 33.31 | 13.24 | 289 | 109825 | 87431 | 56094522 |
Folliculitis | 33.28 | 13.24 | 35 | 110079 | 54944 | 56127009 |
Dyskinesia | 33.25 | 13.24 | 8 | 110106 | 29100 | 56152853 |
Left ventricular dilatation | 33.14 | 13.24 | 17 | 110097 | 464 | 56181489 |
Eosinophil percentage increased | 33.12 | 13.24 | 22 | 110092 | 982 | 56180971 |
Electrocardiogram QT prolonged | 32.76 | 13.24 | 35 | 110079 | 54553 | 56127400 |
Blood alkaline phosphatase increased | 32.74 | 13.24 | 157 | 109957 | 38788 | 56143165 |
Lymphadenopathy | 32.60 | 13.24 | 146 | 109968 | 35062 | 56146891 |
Blood glucose increased | 32.38 | 13.24 | 61 | 110053 | 75090 | 56106863 |
Cardiac disorder | 32.30 | 13.24 | 176 | 109938 | 45711 | 56136242 |
Gait inability | 32.26 | 13.24 | 21 | 110093 | 41797 | 56140156 |
Excessive eye blinking | 32.24 | 13.24 | 22 | 110092 | 1027 | 56180926 |
Chronic obstructive pulmonary disease | 32.08 | 13.24 | 39 | 110075 | 57376 | 56124577 |
Aggression | 32.06 | 13.24 | 3 | 110111 | 22003 | 56159950 |
Unresponsive to stimuli | 32.04 | 13.24 | 11 | 110103 | 31714 | 56150239 |
Acute pulmonary oedema | 31.84 | 13.24 | 55 | 110059 | 7542 | 56174411 |
Product prescribing error | 31.65 | 13.24 | 4 | 110110 | 23182 | 56158771 |
Therapy interrupted | 31.40 | 13.24 | 6 | 110108 | 25619 | 56156334 |
Sense of oppression | 31.25 | 13.24 | 21 | 110093 | 956 | 56180997 |
Metastases to breast | 31.00 | 13.24 | 14 | 110100 | 286 | 56181667 |
Therapy partial responder | 30.87 | 13.24 | 55 | 110059 | 7730 | 56174223 |
Basal cell carcinoma | 30.70 | 13.24 | 6 | 110108 | 25215 | 56156738 |
Delirium | 30.62 | 13.24 | 23 | 110091 | 42494 | 56139459 |
Central nervous system lesion | 30.52 | 13.24 | 63 | 110051 | 9875 | 56172078 |
Device issue | 30.43 | 13.24 | 3 | 110111 | 21103 | 56160850 |
Hypoxia | 30.38 | 13.24 | 195 | 109919 | 53702 | 56128251 |
Perforation | 29.95 | 13.24 | 21 | 110093 | 1025 | 56180928 |
Myocarditis | 29.41 | 13.24 | 58 | 110056 | 8800 | 56173153 |
Diabetes mellitus | 29.28 | 13.24 | 36 | 110078 | 52699 | 56129254 |
Rhabdomyolysis | 29.27 | 13.24 | 22 | 110092 | 40636 | 56141317 |
Accidental overdose | 29.26 | 13.24 | 3 | 110111 | 20458 | 56161495 |
Hair texture abnormal | 29.12 | 13.24 | 37 | 110077 | 3855 | 56178098 |
Pulmonary toxicity | 29.11 | 13.24 | 54 | 110060 | 7829 | 56174124 |
Hypoglycaemia | 29.04 | 13.24 | 40 | 110074 | 55775 | 56126178 |
Metastases to pleura | 28.95 | 13.24 | 23 | 110091 | 1359 | 56180594 |
Breast disorder | 28.92 | 13.24 | 29 | 110085 | 2330 | 56179623 |
Depressed level of consciousness | 28.80 | 13.24 | 41 | 110073 | 56392 | 56125561 |
Irritability | 28.62 | 13.24 | 11 | 110103 | 29577 | 56152376 |
Bladder irritation | 28.47 | 13.24 | 12 | 110102 | 206 | 56181747 |
Tumour marker abnormal | 28.38 | 13.24 | 14 | 110100 | 351 | 56181602 |
Malignant pleural effusion | 28.34 | 13.24 | 29 | 110085 | 2387 | 56179566 |
Vulvovaginal inflammation | 28.31 | 13.24 | 18 | 110096 | 745 | 56181208 |
Mouth ulceration | 28.26 | 13.24 | 124 | 109990 | 29516 | 56152437 |
Seroma | 28.17 | 13.24 | 26 | 110088 | 1885 | 56180068 |
Biliary sepsis | 28.08 | 13.24 | 19 | 110095 | 875 | 56181078 |
Hepatic lesion | 28.03 | 13.24 | 38 | 110076 | 4217 | 56177736 |
Vocal cord paralysis | 27.87 | 13.24 | 26 | 110088 | 1911 | 56180042 |
Hip arthroplasty | 27.68 | 13.24 | 21 | 110093 | 38602 | 56143351 |
Joint injury | 27.50 | 13.24 | 8 | 110106 | 25646 | 56156307 |
Multiple sclerosis | 27.46 | 13.24 | 10 | 110104 | 27792 | 56154161 |
Eye pain | 27.40 | 13.24 | 13 | 110101 | 30834 | 56151119 |
Red cell distribution width increased | 27.28 | 13.24 | 58 | 110056 | 9282 | 56172671 |
Nephrolithiasis | 27.14 | 13.24 | 20 | 110094 | 37315 | 56144638 |
Treatment noncompliance | 27.11 | 13.24 | 15 | 110099 | 32608 | 56149345 |
Keratitis | 26.75 | 13.24 | 31 | 110083 | 2936 | 56179017 |
Gastric disorder | 26.55 | 13.24 | 16 | 110098 | 33194 | 56148759 |
Orthostatic hypotension | 26.54 | 13.24 | 16 | 110098 | 33183 | 56148770 |
Diastolic dysfunction | 26.50 | 13.24 | 43 | 110071 | 5602 | 56176351 |
Cardio-respiratory arrest | 26.48 | 13.24 | 42 | 110072 | 55279 | 56126674 |
Blood pressure fluctuation | 26.39 | 13.24 | 24 | 110090 | 40336 | 56141617 |
Bone lesion | 26.37 | 13.24 | 42 | 110072 | 5388 | 56176565 |
Rash pustular | 26.32 | 13.24 | 47 | 110067 | 6616 | 56175337 |
Axillary vein thrombosis | 26.31 | 13.24 | 13 | 110101 | 327 | 56181626 |
Retinal detachment | 26.30 | 13.24 | 42 | 110072 | 5399 | 56176554 |
Breast oedema | 26.30 | 13.24 | 8 | 110106 | 49 | 56181904 |
Eosinophilia | 26.14 | 13.24 | 4 | 110110 | 20073 | 56161880 |
Sensory disturbance | 25.86 | 13.24 | 68 | 110046 | 12475 | 56169478 |
Bile duct stenosis | 25.59 | 13.24 | 20 | 110094 | 1154 | 56180799 |
Bursitis | 25.47 | 13.24 | 11 | 110103 | 27571 | 56154382 |
Hiccups | 25.41 | 13.24 | 25 | 110089 | 1963 | 56179990 |
Nodular regenerative hyperplasia | 25.27 | 13.24 | 14 | 110100 | 448 | 56181505 |
Dysuria | 25.20 | 13.24 | 123 | 109991 | 30606 | 56151347 |
Blood creatine increased | 25.10 | 13.24 | 40 | 110074 | 5133 | 56176820 |
Calcium ionised increased | 24.98 | 13.24 | 9 | 110105 | 99 | 56181854 |
Type 2 diabetes mellitus | 24.97 | 13.24 | 33 | 110081 | 46829 | 56135124 |
Nail bed bleeding | 24.88 | 13.24 | 12 | 110102 | 286 | 56181667 |
Hydrothorax | 24.81 | 13.24 | 17 | 110097 | 799 | 56181154 |
Hepatitis B reactivation | 24.71 | 13.24 | 27 | 110087 | 2397 | 56179556 |
Gastrointestinal haemorrhage | 24.44 | 13.24 | 72 | 110042 | 75879 | 56106074 |
Respiratory arrest | 24.14 | 13.24 | 15 | 110099 | 30610 | 56151343 |
Brachial plexopathy | 24.13 | 13.24 | 9 | 110105 | 110 | 56181843 |
Asthenopia | 24.09 | 13.24 | 25 | 110089 | 2092 | 56179861 |
Tumour lysis syndrome | 24.07 | 13.24 | 50 | 110064 | 7873 | 56174080 |
Hypervolaemia | 23.73 | 13.24 | 11 | 110103 | 26447 | 56155506 |
Mental status changes | 23.69 | 13.24 | 23 | 110091 | 37478 | 56144475 |
Injection site haemorrhage | 23.66 | 13.24 | 7 | 110107 | 22194 | 56159759 |
Vessel puncture site bruise | 23.55 | 13.24 | 13 | 110101 | 413 | 56181540 |
Eastern Cooperative Oncology Group performance status worsened | 23.43 | 13.24 | 17 | 110097 | 876 | 56181077 |
Hypoaesthesia | 23.42 | 13.24 | 398 | 109716 | 141093 | 56040860 |
Mean platelet volume decreased | 23.35 | 13.24 | 25 | 110089 | 2169 | 56179784 |
Nasal disorder | 23.31 | 13.24 | 27 | 110087 | 2555 | 56179398 |
Product quality issue | 23.07 | 13.24 | 17 | 110097 | 31719 | 56150234 |
Odynophagia | 23.07 | 13.24 | 45 | 110069 | 6773 | 56175180 |
Osteolysis | 23.05 | 13.24 | 27 | 110087 | 2586 | 56179367 |
Dysaesthesia | 23.03 | 13.24 | 34 | 110080 | 4082 | 56177871 |
Nail ridging | 22.73 | 13.24 | 12 | 110102 | 348 | 56181605 |
Distichiasis | 22.67 | 13.24 | 6 | 110108 | 20 | 56181933 |
Vulvovaginal dryness | 22.63 | 13.24 | 26 | 110088 | 2439 | 56179514 |
Flushing | 22.60 | 13.24 | 223 | 109891 | 69877 | 56112076 |
Breast cellulitis | 22.40 | 13.24 | 14 | 110100 | 562 | 56181391 |
Vascular fragility | 22.40 | 13.24 | 9 | 110105 | 136 | 56181817 |
Swollen tongue | 22.36 | 13.24 | 16 | 110098 | 30308 | 56151645 |
Acute leukaemia | 22.36 | 13.24 | 18 | 110096 | 1084 | 56180869 |
Abnormal behaviour | 22.33 | 13.24 | 6 | 110108 | 20266 | 56161687 |
Multicentric reticulohistiocytosis | 22.26 | 13.24 | 5 | 110109 | 6 | 56181947 |
Acoustic stimulation tests abnormal | 22.20 | 13.24 | 8 | 110106 | 88 | 56181865 |
Lymphangitis | 22.16 | 13.24 | 16 | 110098 | 818 | 56181135 |
Illness | 22.00 | 13.24 | 21 | 110093 | 34490 | 56147463 |
Embolism | 21.82 | 13.24 | 46 | 110068 | 7318 | 56174635 |
Palmar erythema | 21.81 | 13.24 | 21 | 110093 | 1606 | 56180347 |
Plantar erythema | 21.76 | 13.24 | 10 | 110104 | 213 | 56181740 |
Coronary artery disease | 21.74 | 13.24 | 17 | 110097 | 30779 | 56151174 |
Rhinorrhoea | 21.69 | 13.24 | 188 | 109926 | 56849 | 56125104 |
Tricuspid valve incompetence | 21.61 | 13.24 | 66 | 110048 | 13187 | 56168766 |
Osteosclerosis | 21.58 | 13.24 | 31 | 110083 | 3632 | 56178321 |
Sopor | 21.57 | 13.24 | 7 | 110107 | 20915 | 56161038 |
Sarcoid-like reaction | 21.43 | 13.24 | 5 | 110109 | 8 | 56181945 |
Disorientation | 21.39 | 13.24 | 24 | 110090 | 36589 | 56145364 |
Intercepted product preparation error | 21.35 | 13.24 | 13 | 110101 | 498 | 56181455 |
Secondary cerebellar degeneration | 21.29 | 13.24 | 7 | 110107 | 57 | 56181896 |
Kidney infection | 21.25 | 13.24 | 7 | 110107 | 20718 | 56161235 |
Cardiac tamponade | 21.17 | 13.24 | 34 | 110080 | 4392 | 56177561 |
Prescribed underdose | 21.08 | 13.24 | 7 | 110107 | 20610 | 56161343 |
Dyschezia | 21.07 | 13.24 | 23 | 110091 | 2040 | 56179913 |
Pustule | 20.91 | 13.24 | 19 | 110095 | 1350 | 56180603 |
Full blood count abnormal | 20.81 | 13.24 | 13 | 110101 | 26449 | 56155504 |
Cytomegalovirus infection | 20.72 | 13.24 | 6 | 110108 | 19290 | 56162663 |
Atrial thrombosis | 20.71 | 13.24 | 20 | 110094 | 1535 | 56180418 |
Left ventricular enlargement | 20.58 | 13.24 | 7 | 110107 | 64 | 56181889 |
Osteitis condensans | 20.58 | 13.24 | 6 | 110108 | 31 | 56181922 |
Bone sequestrum | 20.58 | 13.24 | 19 | 110095 | 1378 | 56180575 |
Superior vena cava syndrome | 20.55 | 13.24 | 14 | 110100 | 652 | 56181301 |
Gamma-glutamyltransferase increased | 20.54 | 13.24 | 117 | 109997 | 30888 | 56151065 |
Medication error | 20.40 | 13.24 | 32 | 110082 | 42303 | 56139650 |
Emotional distress | 20.30 | 13.24 | 17 | 110097 | 29746 | 56152207 |
Headache | 20.23 | 13.24 | 891 | 109223 | 558153 | 55623800 |
Infection | 20.18 | 13.24 | 273 | 109841 | 199933 | 55982020 |
Sequestrectomy | 20.15 | 13.24 | 15 | 110099 | 804 | 56181149 |
Tooth extraction | 20.12 | 13.24 | 52 | 110062 | 9441 | 56172512 |
Toxic optic neuropathy | 19.92 | 13.24 | 9 | 110105 | 184 | 56181769 |
Hypothalamo-pituitary disorder | 19.92 | 13.24 | 14 | 110100 | 686 | 56181267 |
Pneumonitis chemical | 19.88 | 13.24 | 9 | 110105 | 185 | 56181768 |
Viral infection | 19.71 | 13.24 | 20 | 110094 | 31926 | 56150027 |
Myeloproliferative neoplasm | 19.61 | 13.24 | 12 | 110102 | 464 | 56181489 |
Metastases to the mediastinum | 19.58 | 13.24 | 12 | 110102 | 465 | 56181488 |
Xerophthalmia | 19.56 | 13.24 | 12 | 110102 | 466 | 56181487 |
Bone erosion | 19.46 | 13.24 | 3 | 110111 | 14971 | 56166982 |
Hepatic failure | 19.39 | 13.24 | 122 | 109992 | 33364 | 56148589 |
Post-traumatic pain | 19.38 | 13.24 | 11 | 110103 | 369 | 56181584 |
Gallbladder disorder | 19.34 | 13.24 | 5 | 110109 | 17329 | 56164624 |
Gait apraxia | 19.29 | 13.24 | 5 | 110109 | 15 | 56181938 |
Pneumocystis jirovecii pneumonia | 19.22 | 13.24 | 71 | 110043 | 15630 | 56166323 |
Cardiac failure chronic | 19.12 | 13.24 | 31 | 110083 | 4036 | 56177917 |
Fluid retention | 19.09 | 13.24 | 49 | 110065 | 54029 | 56127924 |
Chromosomal mutation | 19.05 | 13.24 | 5 | 110109 | 16 | 56181937 |
Cystoid macular oedema | 19.00 | 13.24 | 19 | 110095 | 1522 | 56180431 |
Neutropenic colitis | 18.84 | 13.24 | 25 | 110089 | 2718 | 56179235 |
Brain oedema | 18.82 | 13.24 | 63 | 110051 | 13208 | 56168745 |
Transaminases | 18.81 | 13.24 | 7 | 110107 | 85 | 56181868 |
Creatinine renal clearance decreased | 18.73 | 13.24 | 3 | 110111 | 14556 | 56167397 |
Injection site rash | 18.71 | 13.24 | 5 | 110109 | 16953 | 56165000 |
Rectal haemorrhage | 18.65 | 13.24 | 142 | 109972 | 41325 | 56140628 |
Corneal disorder | 18.61 | 13.24 | 20 | 110094 | 1742 | 56180211 |
Sinus congestion | 18.60 | 13.24 | 4 | 110110 | 15720 | 56166233 |
Nasopharyngitis | 18.60 | 13.24 | 312 | 109802 | 220647 | 55961306 |
Leukaemia cutis | 18.59 | 13.24 | 7 | 110107 | 88 | 56181865 |
Entropion | 18.57 | 13.24 | 6 | 110108 | 46 | 56181907 |
Autonomic neuropathy | 18.44 | 13.24 | 16 | 110098 | 1069 | 56180884 |
Therapy non-responder | 18.44 | 13.24 | 60 | 110054 | 61295 | 56120658 |
Pruritus | 18.40 | 13.24 | 475 | 109639 | 316148 | 55865805 |
Spinal pain | 18.28 | 13.24 | 58 | 110056 | 11826 | 56170127 |
Hydrocephalus | 18.20 | 13.24 | 34 | 110080 | 4955 | 56176998 |
Breast sarcoma | 18.19 | 13.24 | 4 | 110110 | 4 | 56181949 |
Dysarthria | 18.02 | 13.24 | 31 | 110083 | 39519 | 56142434 |
Gingival bleeding | 18.00 | 13.24 | 57 | 110057 | 11609 | 56170344 |
Congenital syphilitic osteochondritis | 17.99 | 13.24 | 5 | 110109 | 21 | 56181932 |
Skin disorder | 17.90 | 13.24 | 100 | 110014 | 26209 | 56155744 |
Vasogenic cerebral oedema | 17.86 | 13.24 | 12 | 110102 | 546 | 56181407 |
Paralysis recurrent laryngeal nerve | 17.82 | 13.24 | 6 | 110108 | 53 | 56181900 |
Inflammation | 17.81 | 13.24 | 72 | 110042 | 68999 | 56112954 |
Pleural disorder | 17.78 | 13.24 | 12 | 110102 | 550 | 56181403 |
Pericardial effusion malignant | 17.78 | 13.24 | 7 | 110107 | 100 | 56181853 |
Telangiectasia | 17.65 | 13.24 | 14 | 110100 | 825 | 56181128 |
Bradycardia | 17.64 | 13.24 | 70 | 110044 | 67434 | 56114519 |
Status epilepticus | 17.61 | 13.24 | 4 | 110110 | 15137 | 56166816 |
Gastritis | 17.42 | 13.24 | 122 | 109992 | 34580 | 56147373 |
Overflow diarrhoea | 17.41 | 13.24 | 7 | 110107 | 106 | 56181847 |
Chest wall abscess | 17.34 | 13.24 | 6 | 110108 | 58 | 56181895 |
Renal impairment | 17.32 | 13.24 | 90 | 110024 | 80623 | 56101330 |
Noninfective conjunctivitis | 17.30 | 13.24 | 4 | 110110 | 6 | 56181947 |
Surgery | 17.18 | 13.24 | 23 | 110091 | 32463 | 56149490 |
Skin laceration | 17.14 | 13.24 | 9 | 110105 | 20147 | 56161806 |
Dilatation ventricular | 17.13 | 13.24 | 22 | 110092 | 2316 | 56179637 |
Botryomycosis | 17.12 | 13.24 | 5 | 110109 | 26 | 56181927 |
Pituitary tumour | 17.08 | 13.24 | 14 | 110100 | 865 | 56181088 |
Barotrauma | 17.05 | 13.24 | 8 | 110106 | 179 | 56181774 |
Neuromyopathy | 17.02 | 13.24 | 12 | 110102 | 591 | 56181362 |
Hypersensitivity | 17.01 | 13.24 | 377 | 109737 | 256031 | 55925922 |
Spider naevus | 17.00 | 13.24 | 7 | 110107 | 113 | 56181840 |
Breast ulceration | 16.99 | 13.24 | 6 | 110108 | 62 | 56181891 |
Inflammatory carcinoma of the breast | 16.99 | 13.24 | 6 | 110108 | 62 | 56181891 |
Breast haemorrhage | 16.97 | 13.24 | 8 | 110106 | 181 | 56181772 |
Hepatic cancer metastatic | 16.93 | 13.24 | 10 | 110104 | 362 | 56181591 |
Retracted nipple | 16.92 | 13.24 | 4 | 110110 | 7 | 56181946 |
Hyperaesthesia | 16.91 | 13.24 | 46 | 110068 | 8611 | 56173342 |
Nasal ulcer | 16.86 | 13.24 | 20 | 110094 | 1942 | 56180011 |
Capillary leak syndrome | 16.82 | 13.24 | 20 | 110094 | 1946 | 56180007 |
Breast induration | 16.81 | 13.24 | 5 | 110109 | 28 | 56181925 |
Herpangina | 16.81 | 13.24 | 5 | 110109 | 28 | 56181925 |
Disability | 16.77 | 13.24 | 5 | 110109 | 15775 | 56166178 |
Oral candidiasis | 16.76 | 13.24 | 77 | 110037 | 18686 | 56163267 |
Joint dislocation | 16.76 | 13.24 | 5 | 110109 | 15768 | 56166185 |
Toxic neuropathy | 16.69 | 13.24 | 10 | 110104 | 372 | 56181581 |
Cholangiectasis acquired | 16.58 | 13.24 | 4 | 110110 | 8 | 56181945 |
Device dislocation | 16.57 | 13.24 | 12 | 110102 | 22594 | 56159359 |
Nasal crusting | 16.56 | 13.24 | 9 | 110105 | 277 | 56181676 |
Aortic valve incompetence | 16.56 | 13.24 | 35 | 110079 | 5577 | 56176376 |
Hepatic neoplasm | 16.54 | 13.24 | 19 | 110095 | 1782 | 56180171 |
Hyperchlorhydria | 16.48 | 13.24 | 18 | 110096 | 1597 | 56180356 |
Respiratory tract congestion | 16.46 | 13.24 | 5 | 110109 | 15586 | 56166367 |
Arachnoid cyst | 16.42 | 13.24 | 8 | 110106 | 195 | 56181758 |
Metabolic acidosis | 16.42 | 13.24 | 34 | 110080 | 40420 | 56141533 |
Full blood count decreased | 16.34 | 13.24 | 13 | 110101 | 23336 | 56158617 |
Subclavian vein thrombosis | 16.28 | 13.24 | 19 | 110095 | 1813 | 56180140 |
Jaundice | 16.15 | 13.24 | 100 | 110014 | 27194 | 56154759 |
Upper respiratory tract infection | 16.15 | 13.24 | 78 | 110036 | 71210 | 56110743 |
Adenocarcinoma gastric | 16.13 | 13.24 | 11 | 110103 | 513 | 56181440 |
Frequent bowel movements | 16.06 | 13.24 | 6 | 110108 | 16418 | 56165535 |
Blood pressure systolic increased | 16.01 | 13.24 | 35 | 110079 | 40801 | 56141152 |
Mucosal dryness | 15.99 | 13.24 | 22 | 110092 | 2476 | 56179477 |
Merycism | 15.95 | 13.24 | 8 | 110106 | 208 | 56181745 |
Metastases to nervous system | 15.74 | 13.24 | 5 | 110109 | 36 | 56181917 |
Inflammatory carcinoma of breast stage IV | 15.72 | 13.24 | 3 | 110111 | 0 | 56181953 |
Left atrial volume increased | 15.72 | 13.24 | 3 | 110111 | 0 | 56181953 |
Multiple gated acquisition scan abnormal | 15.72 | 13.24 | 3 | 110111 | 0 | 56181953 |
Globulinuria | 15.72 | 13.24 | 3 | 110111 | 0 | 56181953 |
Poisoning | 15.70 | 13.24 | 3 | 110111 | 12810 | 56169143 |
Gingival pain | 15.66 | 13.24 | 37 | 110077 | 6351 | 56175602 |
Transient ischaemic attack | 15.59 | 13.24 | 26 | 110088 | 33551 | 56148402 |
Thyroid disorder | 15.59 | 13.24 | 4 | 110110 | 13934 | 56168019 |
Blood phosphorus decreased | 15.54 | 13.24 | 28 | 110086 | 3969 | 56177984 |
Apical granuloma | 15.51 | 13.24 | 5 | 110109 | 38 | 56181915 |
Product administration error | 15.49 | 13.24 | 11 | 110103 | 20918 | 56161035 |
Therapeutic response unexpected | 15.42 | 13.24 | 7 | 110107 | 17037 | 56164916 |
Extravasation | 15.42 | 13.24 | 20 | 110094 | 2127 | 56179826 |
Bone cancer metastatic | 15.41 | 13.24 | 7 | 110107 | 145 | 56181808 |
Intracranial pressure increased | 15.38 | 13.24 | 30 | 110084 | 4515 | 56177438 |
Agitation | 15.35 | 13.24 | 57 | 110057 | 55979 | 56125974 |
Back pain | 15.35 | 13.24 | 588 | 109526 | 236582 | 55945371 |
Fear | 15.35 | 13.24 | 5 | 110109 | 14903 | 56167050 |
Catheter site pain | 15.34 | 13.24 | 29 | 110085 | 4264 | 56177689 |
Sepsis | 15.34 | 13.24 | 370 | 109744 | 139470 | 56042483 |
Joint effusion | 15.33 | 13.24 | 5 | 110109 | 14893 | 56167060 |
Vaginal prolapse | 15.30 | 13.24 | 10 | 110104 | 434 | 56181519 |
Infusion site pain | 15.30 | 13.24 | 4 | 110110 | 13758 | 56168195 |
Bronchospasm | 15.28 | 13.24 | 66 | 110048 | 15603 | 56166350 |
Scintillating scotoma | 15.24 | 13.24 | 7 | 110107 | 149 | 56181804 |
Dyspnoea at rest | 15.20 | 13.24 | 27 | 110087 | 3786 | 56178167 |
Acral peeling skin syndrome | 15.19 | 13.24 | 4 | 110110 | 13 | 56181940 |
Bone disorder | 15.15 | 13.24 | 77 | 110037 | 19466 | 56162487 |
Pneumonia aspiration | 15.14 | 13.24 | 25 | 110089 | 32386 | 56149567 |
Superinfection | 15.12 | 13.24 | 20 | 110094 | 2168 | 56179785 |
Respiratory depression | 15.05 | 13.24 | 3 | 110111 | 12432 | 56169521 |
Abdominal rigidity | 15.01 | 13.24 | 18 | 110096 | 1767 | 56180186 |
Hiatus hernia | 14.98 | 13.24 | 10 | 110104 | 19642 | 56162311 |
Oropharyngeal candidiasis | 14.97 | 13.24 | 14 | 110100 | 1032 | 56180921 |
Rash follicular | 14.97 | 13.24 | 5 | 110109 | 43 | 56181910 |
Gram stain positive | 14.97 | 13.24 | 5 | 110109 | 43 | 56181910 |
Dizziness | 14.94 | 13.24 | 593 | 109521 | 375547 | 55806406 |
Nervousness | 14.88 | 13.24 | 21 | 110093 | 28994 | 56152959 |
HER2 negative breast cancer | 14.87 | 13.24 | 5 | 110109 | 44 | 56181909 |
Blood bilirubin decreased | 14.86 | 13.24 | 12 | 110102 | 726 | 56181227 |
Dandy-Walker syndrome | 14.85 | 13.24 | 6 | 110108 | 92 | 56181861 |
Impaired work ability | 14.80 | 13.24 | 5 | 110109 | 14567 | 56167386 |
Ocular vasculitis | 14.77 | 13.24 | 5 | 110109 | 45 | 56181908 |
Hypoalbuminaemia | 14.75 | 13.24 | 50 | 110064 | 10549 | 56171404 |
Laboratory test abnormal | 14.63 | 13.24 | 16 | 110098 | 24679 | 56157274 |
Essential thrombocythaemia | 14.62 | 13.24 | 7 | 110107 | 164 | 56181789 |
Myositis | 14.59 | 13.24 | 43 | 110071 | 8425 | 56173528 |
Central nervous system neoplasm | 14.55 | 13.24 | 4 | 110110 | 16 | 56181937 |
Rotator cuff syndrome | 14.55 | 13.24 | 3 | 110111 | 12140 | 56169813 |
Underdose | 14.51 | 13.24 | 15 | 110099 | 23742 | 56158211 |
SAPHO syndrome | 14.45 | 13.24 | 6 | 110108 | 99 | 56181854 |
Vena cava thrombosis | 14.43 | 13.24 | 19 | 110095 | 2050 | 56179903 |
Feeling jittery | 14.38 | 13.24 | 3 | 110111 | 12043 | 56169910 |
Hypocalcaemia | 14.37 | 13.24 | 101 | 110013 | 28659 | 56153294 |
Vulvovaginal candidiasis | 14.37 | 13.24 | 23 | 110091 | 2963 | 56178990 |
Glaucoma | 14.35 | 13.24 | 8 | 110106 | 17321 | 56164632 |
Cardiac failure acute | 14.29 | 13.24 | 44 | 110070 | 8829 | 56173124 |
Foot fracture | 14.22 | 13.24 | 13 | 110101 | 21796 | 56160157 |
Nail bed tenderness | 14.21 | 13.24 | 9 | 110105 | 370 | 56181583 |
Stress | 14.21 | 13.24 | 63 | 110051 | 58847 | 56123106 |
Corneal bleeding | 14.17 | 13.24 | 4 | 110110 | 18 | 56181935 |
Intervertebral disc protrusion | 14.06 | 13.24 | 13 | 110101 | 21681 | 56160272 |
Device malfunction | 14.02 | 13.24 | 7 | 110107 | 16129 | 56165824 |
Peripheral sensorimotor neuropathy | 14.02 | 13.24 | 15 | 110099 | 1300 | 56180653 |
Pneumothorax | 14.02 | 13.24 | 62 | 110052 | 14805 | 56167148 |
Skin infection | 13.97 | 13.24 | 57 | 110057 | 13138 | 56168815 |
Catheter site erythema | 13.94 | 13.24 | 27 | 110087 | 4043 | 56177910 |
Dacryostenosis acquired | 13.87 | 13.24 | 10 | 110104 | 510 | 56181443 |
Vagus nerve disorder | 13.78 | 13.24 | 6 | 110108 | 112 | 56181841 |
Pulmonary arterial hypertension | 13.78 | 13.24 | 19 | 110095 | 26484 | 56155469 |
Crying | 13.72 | 13.24 | 13 | 110101 | 21427 | 56160526 |
Cerebrovascular accident | 13.71 | 13.24 | 126 | 109988 | 99144 | 56082809 |
Anal erythema | 13.68 | 13.24 | 7 | 110107 | 190 | 56181763 |
Limb injury | 13.68 | 13.24 | 14 | 110100 | 22256 | 56159697 |
Folate deficiency | 13.68 | 13.24 | 19 | 110095 | 2158 | 56179795 |
Urogenital prolapse | 13.67 | 13.24 | 4 | 110110 | 21 | 56181932 |
Gastrointestinal ulcer perforation | 13.64 | 13.24 | 3 | 110111 | 3 | 56181950 |
Metastases to pituitary gland | 13.64 | 13.24 | 3 | 110111 | 3 | 56181950 |
Eye swelling | 13.63 | 13.24 | 13 | 110101 | 21363 | 56160590 |
Road traffic accident | 13.56 | 13.24 | 21 | 110093 | 27906 | 56154047 |
Bone marrow infiltration | 13.54 | 13.24 | 10 | 110104 | 530 | 56181423 |
Arrhythmia | 13.53 | 13.24 | 116 | 109998 | 34967 | 56146986 |
Bacterial rhinitis | 13.51 | 13.24 | 4 | 110110 | 22 | 56181931 |
Soft tissue infection | 13.48 | 13.24 | 18 | 110096 | 1969 | 56179984 |
Premature delivery | 13.47 | 13.24 | 20 | 110094 | 27040 | 56154913 |
Appendiceal abscess | 13.45 | 13.24 | 7 | 110107 | 197 | 56181756 |
Amnesia | 13.44 | 13.24 | 46 | 110068 | 46276 | 56135677 |
Joint range of motion decreased | 13.37 | 13.24 | 18 | 110096 | 25347 | 56156606 |
Ulcerative keratitis | 13.34 | 13.24 | 20 | 110094 | 2435 | 56179518 |
Naevus haemorrhage | 13.27 | 13.24 | 6 | 110108 | 123 | 56181830 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Disease progression | 199.18 | 25.30 | 149 | 5536 | 90315 | 31601344 |
Off label use | 119.57 | 25.30 | 218 | 5467 | 347056 | 31344603 |
Palmar-plantar erythrodysaesthesia syndrome | 115.25 | 25.30 | 56 | 5629 | 15427 | 31676232 |
Myelosuppression | 108.16 | 25.30 | 53 | 5632 | 14867 | 31676792 |
Death | 89.82 | 25.30 | 198 | 5487 | 360371 | 31331288 |
Oligohydramnios | 73.29 | 25.30 | 16 | 5669 | 322 | 31691337 |
Bone marrow failure | 63.27 | 25.30 | 47 | 5638 | 27961 | 31663698 |
Pulmonary hypoplasia | 63.21 | 25.30 | 15 | 5670 | 443 | 31691216 |
Intentional product use issue | 60.10 | 25.30 | 58 | 5627 | 49289 | 31642370 |
Anastomotic complication | 55.52 | 25.30 | 13 | 5672 | 362 | 31691297 |
Therapy partial responder | 52.63 | 25.30 | 25 | 5660 | 6537 | 31685122 |
Carbohydrate antigen 15-3 increased | 49.11 | 25.30 | 9 | 5676 | 70 | 31691589 |
Tidal volume decreased | 48.15 | 25.30 | 8 | 5677 | 32 | 31691627 |
Ejection fraction decreased | 47.97 | 25.30 | 33 | 5652 | 17401 | 31674258 |
Delusion of grandeur | 47.15 | 25.30 | 13 | 5672 | 704 | 31690955 |
Metastases to central nervous system | 43.29 | 25.30 | 23 | 5662 | 7613 | 31684046 |
Diarrhoea | 40.05 | 25.30 | 146 | 5539 | 352263 | 31339396 |
Gastric perforation | 38.97 | 25.30 | 15 | 5670 | 2344 | 31689315 |
Breast cancer | 35.99 | 25.30 | 9 | 5676 | 332 | 31691327 |
Onycholysis | 35.03 | 25.30 | 10 | 5675 | 615 | 31691044 |
Nasal discomfort | 33.55 | 25.30 | 12 | 5673 | 1528 | 31690131 |
Paranasal sinus discomfort | 33.39 | 25.30 | 10 | 5675 | 728 | 31690931 |
Neuropathy peripheral | 31.56 | 25.30 | 52 | 5633 | 75597 | 31616062 |
Obstruction gastric | 31.52 | 25.30 | 10 | 5675 | 882 | 31690777 |
Anastomotic leak | 30.69 | 25.30 | 9 | 5676 | 609 | 31691050 |
Rectal polyp | 30.45 | 25.30 | 9 | 5676 | 626 | 31691033 |
Alopecia | 30.34 | 25.30 | 27 | 5658 | 20668 | 31670991 |
Metastases to liver | 30.16 | 25.30 | 22 | 5663 | 12705 | 31678954 |
Metastases to lung | 28.14 | 25.30 | 18 | 5667 | 8404 | 31683255 |
Drug interaction | 26.94 | 25.30 | 3 | 5682 | 208540 | 31483119 |
Lymphoedema | 26.90 | 25.30 | 13 | 5672 | 3527 | 31688132 |
Malignant sweat gland neoplasm | 26.46 | 25.30 | 4 | 5681 | 7 | 31691652 |
Affective disorder | 26.23 | 25.30 | 13 | 5672 | 3723 | 31687936 |
Foetal growth restriction | 25.98 | 25.30 | 13 | 5672 | 3802 | 31687857 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ejection fraction decreased | 1754.40 | 13.67 | 822 | 85918 | 29940 | 70811764 |
Myelosuppression | 1320.92 | 13.67 | 673 | 86067 | 29472 | 70812232 |
Diarrhoea | 900.49 | 13.67 | 2531 | 84209 | 780810 | 70060894 |
Palmar-plantar erythrodysaesthesia syndrome | 796.15 | 13.67 | 483 | 86257 | 29764 | 70811940 |
Disease progression | 777.24 | 13.67 | 957 | 85783 | 155715 | 70685989 |
Metastases to central nervous system | 774.88 | 13.67 | 375 | 86365 | 14659 | 70827045 |
Neuropathy peripheral | 630.42 | 13.67 | 776 | 85964 | 126120 | 70715584 |
Cardiotoxicity | 576.10 | 13.67 | 278 | 86462 | 10792 | 70830912 |
Bone marrow failure | 505.92 | 13.67 | 444 | 86296 | 48566 | 70793138 |
Drug ineffective | 434.52 | 13.67 | 312 | 86428 | 939440 | 69902264 |
Breast cancer metastatic | 408.04 | 13.67 | 214 | 86526 | 9932 | 70831772 |
Febrile neutropenia | 395.52 | 13.67 | 811 | 85929 | 203507 | 70638197 |
Metastases to bone | 382.68 | 13.67 | 273 | 86467 | 22103 | 70819601 |
Metastases to liver | 353.74 | 13.67 | 276 | 86464 | 25602 | 70816102 |
Polyneuropathy | 338.25 | 13.67 | 249 | 86491 | 21166 | 70820538 |
Chills | 332.68 | 13.67 | 618 | 86122 | 144168 | 70697536 |
Cardiac dysfunction | 330.49 | 13.67 | 134 | 86606 | 3403 | 70838301 |
Rheumatoid arthritis | 319.18 | 13.67 | 8 | 86732 | 291797 | 70549907 |
Neutropenia | 316.33 | 13.67 | 855 | 85885 | 256301 | 70585403 |
Mucosal inflammation | 301.75 | 13.67 | 393 | 86347 | 67457 | 70774247 |
Metastases to lung | 290.83 | 13.67 | 205 | 86535 | 16279 | 70825425 |
Breast cancer recurrent | 271.95 | 13.67 | 109 | 86631 | 2684 | 70839020 |
Left ventricular dysfunction | 250.79 | 13.67 | 194 | 86546 | 17763 | 70823941 |
Metastases to lymph nodes | 244.16 | 13.67 | 148 | 86592 | 9090 | 70832614 |
Drug interaction | 211.71 | 13.67 | 101 | 86639 | 381340 | 70460364 |
Lymphoedema | 190.31 | 13.67 | 136 | 86604 | 11033 | 70830671 |
Fall | 187.18 | 13.67 | 161 | 86579 | 443935 | 70397769 |
Cardiomyopathy | 186.49 | 13.67 | 194 | 86546 | 26179 | 70815525 |
Breast cancer | 185.65 | 13.67 | 217 | 86523 | 33332 | 70808372 |
Interstitial lung disease | 183.01 | 13.67 | 399 | 86341 | 104286 | 70737418 |
Malignant neoplasm progression | 174.36 | 13.67 | 429 | 86311 | 121310 | 70720394 |
Nausea | 174.16 | 13.67 | 1695 | 85045 | 850393 | 69991311 |
Neutropenic sepsis | 170.83 | 13.67 | 180 | 86560 | 24650 | 70817054 |
Condition aggravated | 168.37 | 13.67 | 165 | 86575 | 427470 | 70414234 |
Peripheral sensory neuropathy | 167.28 | 13.67 | 130 | 86610 | 11980 | 70829724 |
Stomatitis | 165.47 | 13.67 | 435 | 86305 | 128076 | 70713628 |
Drug abuse | 164.98 | 13.67 | 3 | 86737 | 147253 | 70694451 |
Drug hypersensitivity | 157.41 | 13.67 | 62 | 86678 | 262397 | 70579307 |
Onycholysis | 157.17 | 13.67 | 65 | 86675 | 1738 | 70839966 |
Toxicity to various agents | 155.63 | 13.67 | 143 | 86597 | 382029 | 70459675 |
Joint swelling | 148.30 | 13.67 | 62 | 86678 | 253149 | 70588555 |
Computerised tomogram thorax abnormal | 144.45 | 13.67 | 64 | 86676 | 2034 | 70839670 |
Synovitis | 143.28 | 13.67 | 3 | 86737 | 129225 | 70712479 |
Contraindicated product administered | 142.30 | 13.67 | 5 | 86735 | 134607 | 70707097 |
Neoplasm progression | 139.21 | 13.67 | 220 | 86520 | 45008 | 70796696 |
Cardiac failure | 133.87 | 13.67 | 433 | 86307 | 143108 | 70698596 |
Osteonecrosis of jaw | 132.54 | 13.67 | 204 | 86536 | 40798 | 70800906 |
Product dose omission issue | 127.72 | 13.67 | 53 | 86687 | 217415 | 70624289 |
Epistaxis | 127.63 | 13.67 | 343 | 86397 | 102284 | 70739420 |
Metastases to skin | 124.76 | 13.67 | 53 | 86687 | 1518 | 70840186 |
Confusional state | 123.51 | 13.67 | 100 | 86640 | 284298 | 70557406 |
Therapeutic product effect decreased | 118.42 | 13.67 | 17 | 86723 | 143001 | 70698703 |
Pleural effusion | 117.79 | 13.67 | 394 | 86346 | 132470 | 70709234 |
Nail disorder | 116.72 | 13.67 | 99 | 86641 | 10325 | 70831379 |
Metastasis | 114.76 | 13.67 | 79 | 86661 | 6035 | 70835669 |
Skin toxicity | 114.32 | 13.67 | 84 | 86656 | 7114 | 70834590 |
Nail toxicity | 114.24 | 13.67 | 34 | 86706 | 326 | 70841378 |
Vomiting | 111.58 | 13.67 | 1161 | 85579 | 591950 | 70249754 |
Biopsy lung abnormal | 109.82 | 13.67 | 28 | 86712 | 140 | 70841564 |
Hypokalaemia | 109.25 | 13.67 | 381 | 86359 | 130807 | 70710897 |
Bone pain | 106.74 | 13.67 | 209 | 86531 | 50613 | 70791091 |
Overdose | 105.23 | 13.67 | 38 | 86702 | 169707 | 70671997 |
Gastrointestinal toxicity | 104.56 | 13.67 | 76 | 86664 | 6329 | 70835375 |
Invasive ductal breast carcinoma | 101.88 | 13.67 | 72 | 86668 | 5737 | 70835967 |
Pneumonitis | 100.99 | 13.67 | 213 | 86527 | 54384 | 70787320 |
Alveolitis | 100.56 | 13.67 | 61 | 86679 | 3750 | 70837954 |
Hyperpyrexia | 99.83 | 13.67 | 69 | 86671 | 5305 | 70836399 |
Arthropathy | 97.52 | 13.67 | 31 | 86709 | 150026 | 70691678 |
Decreased appetite | 96.74 | 13.67 | 671 | 86069 | 304109 | 70537595 |
Psoriasis | 96.46 | 13.67 | 6 | 86734 | 98427 | 70743277 |
Nail discolouration | 94.56 | 13.67 | 52 | 86688 | 2654 | 70839050 |
Nail dystrophy | 92.30 | 13.67 | 37 | 86703 | 911 | 70840793 |
Systemic lupus erythematosus | 92.04 | 13.67 | 9 | 86731 | 101893 | 70739811 |
Cellulitis | 91.80 | 13.67 | 298 | 86442 | 98630 | 70743074 |
Neurotoxicity | 90.28 | 13.67 | 144 | 86596 | 29682 | 70812022 |
Alopecia | 89.65 | 13.67 | 479 | 86261 | 198011 | 70643693 |
Dysgeusia | 89.10 | 13.67 | 191 | 86549 | 49311 | 70792393 |
Dyspnoea | 89.02 | 13.67 | 1377 | 85363 | 768683 | 70073021 |
Lacrimation increased | 87.98 | 13.67 | 115 | 86625 | 19784 | 70821920 |
Fatigue | 84.85 | 13.67 | 1446 | 85294 | 822873 | 70018831 |
Pyrexia | 83.43 | 13.67 | 1119 | 85621 | 605833 | 70235871 |
Sinusitis | 83.24 | 13.67 | 52 | 86688 | 169143 | 70672561 |
Abdominal discomfort | 80.72 | 13.67 | 86 | 86654 | 214572 | 70627132 |
HER2 positive breast cancer | 80.41 | 13.67 | 26 | 86714 | 335 | 70841369 |
Ventricular hypokinesia | 79.89 | 13.67 | 72 | 86668 | 8140 | 70833564 |
Erysipelas | 79.28 | 13.67 | 78 | 86662 | 9846 | 70831858 |
Madarosis | 78.69 | 13.67 | 45 | 86695 | 2478 | 70839226 |
Treatment failure | 78.55 | 13.67 | 39 | 86701 | 144103 | 70697601 |
Pericardial effusion | 77.27 | 13.67 | 163 | 86577 | 41613 | 70800091 |
Somnolence | 77.10 | 13.67 | 90 | 86650 | 215516 | 70626188 |
Paronychia | 76.78 | 13.67 | 66 | 86674 | 7008 | 70834696 |
Multifocal micronodular pneumocyte hyperplasia | 73.66 | 13.67 | 18 | 86722 | 73 | 70841631 |
Bronchial polyp | 73.27 | 13.67 | 18 | 86722 | 75 | 70841629 |
Hyperkalaemia | 72.93 | 13.67 | 20 | 86720 | 106571 | 70735133 |
Hypertransaminasaemia | 72.77 | 13.67 | 71 | 86669 | 8872 | 70832832 |
Metastases to meninges | 72.13 | 13.67 | 46 | 86694 | 3090 | 70838614 |
Aortitis | 72.08 | 13.67 | 35 | 86705 | 1376 | 70840328 |
Vascular device infection | 71.50 | 13.67 | 67 | 86673 | 7963 | 70833741 |
Rhabdomyolysis | 71.34 | 13.67 | 15 | 86725 | 95745 | 70745959 |
Lymphangiosis carcinomatosa | 70.50 | 13.67 | 38 | 86702 | 1863 | 70839841 |
Plasma cell myeloma | 70.14 | 13.67 | 5 | 86735 | 73196 | 70768508 |
Mitral valve incompetence | 70.10 | 13.67 | 121 | 86619 | 26607 | 70815097 |
Weight increased | 69.87 | 13.67 | 118 | 86622 | 242213 | 70599491 |
Metastatic neoplasm | 68.80 | 13.67 | 52 | 86688 | 4596 | 70837108 |
Recall phenomenon | 68.74 | 13.67 | 31 | 86709 | 1028 | 70840676 |
Inappropriate schedule of product administration | 68.49 | 13.67 | 23 | 86717 | 107532 | 70734172 |
Oligohydramnios | 68.32 | 13.67 | 45 | 86695 | 3195 | 70838509 |
Loss of personal independence in daily activities | 68.19 | 13.67 | 11 | 86729 | 84899 | 70756805 |
Paraesthesia | 66.89 | 13.67 | 353 | 86387 | 145184 | 70696520 |
Suicide attempt | 66.86 | 13.67 | 9 | 86731 | 79501 | 70762203 |
Haematotoxicity | 66.72 | 13.67 | 83 | 86657 | 13591 | 70828113 |
Acute myeloid leukaemia | 64.67 | 13.67 | 127 | 86613 | 30813 | 70810891 |
Colitis | 64.47 | 13.67 | 198 | 86542 | 63616 | 70778088 |
Mastitis | 64.35 | 13.67 | 37 | 86703 | 2059 | 70839645 |
Hot flush | 63.91 | 13.67 | 168 | 86572 | 49416 | 70792288 |
Injection site pain | 63.82 | 13.67 | 32 | 86708 | 117587 | 70724117 |
Metastases to spine | 63.79 | 13.67 | 46 | 86694 | 3783 | 70837921 |
Hospitalisation | 63.46 | 13.67 | 12 | 86728 | 82556 | 70759148 |
Product use issue | 63.37 | 13.67 | 76 | 86664 | 179861 | 70661843 |
Therapy partial responder | 62.93 | 13.67 | 77 | 86663 | 12397 | 70829307 |
Disease recurrence | 61.90 | 13.67 | 140 | 86600 | 37463 | 70804241 |
Alopecia areata | 61.51 | 13.67 | 33 | 86707 | 1603 | 70840101 |
Neutropenic infection | 60.44 | 13.67 | 35 | 86705 | 1974 | 70839730 |
Granulocyte count decreased | 59.74 | 13.67 | 31 | 86709 | 1406 | 70840298 |
Infusion related reaction | 59.73 | 13.67 | 430 | 86310 | 197104 | 70644600 |
Breast pain | 59.00 | 13.67 | 58 | 86682 | 7313 | 70834391 |
Drug reaction with eosinophilia and systemic symptoms | 58.48 | 13.67 | 3 | 86737 | 58010 | 70783694 |
Acute interstitial pneumonitis | 58.11 | 13.67 | 28 | 86712 | 1082 | 70840622 |
Product use in unapproved indication | 58.00 | 13.67 | 103 | 86637 | 207375 | 70634329 |
Tumour marker increased | 57.39 | 13.67 | 43 | 86697 | 3751 | 70837953 |
Cough | 57.24 | 13.67 | 629 | 86111 | 324748 | 70516956 |
Therapeutic product effect incomplete | 56.03 | 13.67 | 39 | 86701 | 119843 | 70721861 |
Onychalgia | 55.95 | 13.67 | 25 | 86715 | 811 | 70840893 |
Organising pneumonia | 55.57 | 13.67 | 65 | 86675 | 9985 | 70831719 |
Lactic acidosis | 55.54 | 13.67 | 7 | 86733 | 65017 | 70776687 |
Radiation skin injury | 55.51 | 13.67 | 29 | 86711 | 1334 | 70840370 |
Pain | 55.49 | 13.67 | 497 | 86243 | 628319 | 70213385 |
Myocardial infarction | 54.79 | 13.67 | 78 | 86662 | 171567 | 70670137 |
Onychoclasis | 53.08 | 13.67 | 46 | 86694 | 4938 | 70836766 |
Neutrophil count decreased | 52.52 | 13.67 | 222 | 86518 | 83334 | 70758370 |
White blood cell count decreased | 52.37 | 13.67 | 372 | 86368 | 169769 | 70671935 |
Device related infection | 50.95 | 13.67 | 118 | 86622 | 32067 | 70809637 |
Chest discomfort | 50.65 | 13.67 | 292 | 86448 | 124089 | 70717615 |
Hair texture abnormal | 50.25 | 13.67 | 37 | 86703 | 3143 | 70838561 |
Mastectomy | 49.93 | 13.67 | 25 | 86715 | 1051 | 70840653 |
Osteonecrosis | 49.60 | 13.67 | 110 | 86630 | 29050 | 70812654 |
Tonsillar disorder | 49.54 | 13.67 | 25 | 86715 | 1069 | 70840635 |
Gastrointestinal haemorrhage | 49.49 | 13.67 | 57 | 86683 | 137351 | 70704353 |
Axillary pain | 48.85 | 13.67 | 30 | 86710 | 1885 | 70839819 |
International normalised ratio increased | 48.45 | 13.67 | 19 | 86721 | 80707 | 70760997 |
Atelectasis | 47.86 | 13.67 | 108 | 86632 | 28854 | 70812850 |
Mobility decreased | 47.48 | 13.67 | 34 | 86706 | 102965 | 70738739 |
Acute kidney injury | 47.32 | 13.67 | 363 | 86377 | 474261 | 70367443 |
Cardio-respiratory arrest | 46.72 | 13.67 | 33 | 86707 | 100644 | 70741060 |
Fibromyalgia | 46.65 | 13.67 | 3 | 86737 | 47871 | 70793833 |
Dermatitis acneiform | 46.40 | 13.67 | 56 | 86684 | 8889 | 70832815 |
Leukopenia | 45.92 | 13.67 | 254 | 86486 | 106306 | 70735398 |
Metastases to chest wall | 45.64 | 13.67 | 18 | 86722 | 424 | 70841280 |
Erythema | 45.36 | 13.67 | 407 | 86333 | 199156 | 70642548 |
Computerised tomogram thorax | 44.61 | 13.67 | 15 | 86725 | 220 | 70841484 |
Drug intolerance | 44.57 | 13.67 | 135 | 86605 | 225552 | 70616152 |
Blood uric acid decreased | 44.54 | 13.67 | 24 | 86716 | 1176 | 70840528 |
Carbohydrate antigen 15-3 increased | 44.49 | 13.67 | 23 | 86717 | 1035 | 70840669 |
Constipation | 44.36 | 13.67 | 488 | 86252 | 251950 | 70589754 |
Arthritis | 44.31 | 13.67 | 33 | 86707 | 97947 | 70743757 |
Myalgia | 44.28 | 13.67 | 354 | 86386 | 167538 | 70674166 |
Injection site erythema | 44.03 | 13.67 | 17 | 86723 | 72907 | 70768797 |
Breast mass | 43.50 | 13.67 | 44 | 86696 | 5741 | 70835963 |
Hair colour changes | 43.39 | 13.67 | 37 | 86703 | 3886 | 70837818 |
Hepatic enzyme increased | 42.91 | 13.67 | 79 | 86661 | 156911 | 70684793 |
Intentional product misuse | 42.65 | 13.67 | 22 | 86718 | 79573 | 70762131 |
Musculoskeletal stiffness | 42.52 | 13.67 | 72 | 86668 | 147688 | 70694016 |
Pseudocirrhosis | 42.07 | 13.67 | 19 | 86721 | 632 | 70841072 |
Dry skin | 41.89 | 13.67 | 157 | 86583 | 55774 | 70785930 |
Meibomian gland dysfunction | 41.83 | 13.67 | 13 | 86727 | 146 | 70841558 |
Asthma | 41.48 | 13.67 | 52 | 86688 | 120741 | 70720963 |
Bradycardia | 41.40 | 13.67 | 55 | 86685 | 124560 | 70717144 |
Hallucination | 40.98 | 13.67 | 21 | 86719 | 76239 | 70765465 |
Delirium | 40.92 | 13.67 | 20 | 86720 | 74594 | 70767110 |
Ejection fraction | 40.91 | 13.67 | 26 | 86714 | 1736 | 70839968 |
Second primary malignancy | 40.86 | 13.67 | 64 | 86676 | 12987 | 70828717 |
Contusion | 40.05 | 13.67 | 59 | 86681 | 127977 | 70713727 |
Sedation | 39.98 | 13.67 | 5 | 86735 | 46726 | 70794978 |
Injury | 39.74 | 13.67 | 15 | 86725 | 65230 | 70776474 |
Anaemia | 39.21 | 13.67 | 702 | 86038 | 402721 | 70438983 |
Breast neoplasm | 39.06 | 13.67 | 20 | 86720 | 882 | 70840822 |
Unresponsive to stimuli | 38.95 | 13.67 | 8 | 86732 | 51923 | 70789781 |
Coronary artery disease | 38.93 | 13.67 | 14 | 86726 | 62722 | 70778982 |
Injection site reaction | 38.83 | 13.67 | 7 | 86733 | 49845 | 70791859 |
Orthostatic hypotension | 38.75 | 13.67 | 8 | 86732 | 51735 | 70789969 |
Hypoglycaemia | 38.68 | 13.67 | 35 | 86705 | 94329 | 70747375 |
Blood lactate dehydrogenase increased | 38.31 | 13.67 | 112 | 86628 | 35015 | 70806689 |
Nail infection | 38.06 | 13.67 | 27 | 86713 | 2164 | 70839540 |
Dermatitis | 37.35 | 13.67 | 77 | 86663 | 19340 | 70822364 |
Cytomegalovirus infection | 37.28 | 13.67 | 3 | 86737 | 39755 | 70801949 |
Radiation necrosis | 36.69 | 13.67 | 15 | 86725 | 389 | 70841315 |
Bladder irritation | 36.68 | 13.67 | 13 | 86727 | 225 | 70841479 |
Blood creatinine decreased | 36.48 | 13.67 | 45 | 86695 | 7304 | 70834400 |
Product prescribing error | 36.35 | 13.67 | 3 | 86737 | 38949 | 70802755 |
Swelling | 36.35 | 13.67 | 114 | 86626 | 188425 | 70653279 |
Adverse event | 36.32 | 13.67 | 8 | 86732 | 49453 | 70792251 |
Central nervous system lesion | 36.15 | 13.67 | 59 | 86681 | 12394 | 70829310 |
Dyskinesia | 36.12 | 13.67 | 4 | 86736 | 41070 | 70800634 |
Duodenal ulcer perforation | 36.08 | 13.67 | 9 | 86731 | 51103 | 70790601 |
Asthenia | 35.91 | 13.67 | 771 | 85969 | 456895 | 70384809 |
Drug ineffective for unapproved indication | 35.88 | 13.67 | 3 | 86737 | 38535 | 70803169 |
Wound | 35.50 | 13.67 | 41 | 86699 | 98691 | 70743013 |
Vulvovaginal dryness | 35.47 | 13.67 | 24 | 86716 | 1782 | 70839922 |
Electrocardiogram QT prolonged | 35.41 | 13.67 | 30 | 86710 | 83487 | 70758217 |
Eosinophilia | 35.27 | 13.67 | 4 | 86736 | 40315 | 70801389 |
Wheezing | 35.06 | 13.67 | 38 | 86702 | 94132 | 70747572 |
Dehydration | 34.73 | 13.67 | 426 | 86314 | 225716 | 70615988 |
Acoustic stimulation tests abnormal | 34.60 | 13.67 | 8 | 86732 | 24 | 70841680 |
Pulmonary mass | 34.35 | 13.67 | 89 | 86651 | 25944 | 70815760 |
Feeling abnormal | 34.31 | 13.67 | 77 | 86663 | 142242 | 70699462 |
Coma | 34.27 | 13.67 | 37 | 86703 | 91807 | 70749897 |
Enterocolitis | 34.06 | 13.67 | 59 | 86681 | 13007 | 70828697 |
Chronic kidney disease | 34.04 | 13.67 | 16 | 86724 | 61041 | 70780663 |
Injection site pruritus | 34.03 | 13.67 | 4 | 86736 | 39206 | 70802498 |
Congestive cardiomyopathy | 33.40 | 13.67 | 53 | 86687 | 10873 | 70830831 |
Recurrent cancer | 33.26 | 13.67 | 26 | 86714 | 2415 | 70839289 |
Mental status changes | 32.99 | 13.67 | 18 | 86722 | 63083 | 70778621 |
Chronic obstructive pulmonary disease | 32.78 | 13.67 | 28 | 86712 | 77613 | 70764091 |
Perforation | 32.74 | 13.67 | 20 | 86720 | 1245 | 70840459 |
Eosinophil percentage increased | 32.68 | 13.67 | 21 | 86719 | 1429 | 70840275 |
Agranulocytosis | 32.61 | 13.67 | 116 | 86624 | 40182 | 70801522 |
Nasal congestion | 32.53 | 13.67 | 20 | 86720 | 65652 | 70776052 |
Cystitis noninfective | 32.36 | 13.67 | 20 | 86720 | 1271 | 70840433 |
Flushing | 32.20 | 13.67 | 191 | 86549 | 81981 | 70759723 |
Jaw operation | 32.14 | 13.67 | 17 | 86723 | 802 | 70840902 |
Accidental overdose | 31.98 | 13.67 | 3 | 86737 | 35118 | 70806586 |
Respiratory arrest | 31.86 | 13.67 | 13 | 86727 | 53920 | 70787784 |
Blood glucose increased | 31.67 | 13.67 | 48 | 86692 | 102934 | 70738770 |
Asthenopia | 31.25 | 13.67 | 24 | 86716 | 2172 | 70839532 |
Arthralgia | 31.15 | 13.67 | 431 | 86309 | 502959 | 70338745 |
Hypoaesthesia | 31.14 | 13.67 | 306 | 86434 | 153433 | 70688271 |
Platelet count decreased | 31.03 | 13.67 | 344 | 86396 | 177878 | 70663826 |
Vascular fragility | 30.99 | 13.67 | 10 | 86730 | 128 | 70841576 |
Discomfort | 30.67 | 13.67 | 51 | 86689 | 105385 | 70736319 |
Depression | 30.67 | 13.67 | 132 | 86608 | 198842 | 70642862 |
Blood pressure fluctuation | 30.61 | 13.67 | 17 | 86723 | 58995 | 70782709 |
Cardiac arrest | 30.56 | 13.67 | 97 | 86643 | 159737 | 70681967 |
Mean platelet volume decreased | 30.46 | 13.67 | 24 | 86716 | 2255 | 70839449 |
Hyperfibrinogenaemia | 30.45 | 13.67 | 9 | 86731 | 84 | 70841620 |
Troponin I increased | 30.44 | 13.67 | 31 | 86709 | 4077 | 70837627 |
Blood cholesterol increased | 30.20 | 13.67 | 21 | 86719 | 64583 | 70777121 |
Tumour pain | 30.01 | 13.67 | 23 | 86717 | 2075 | 70839629 |
Sense of oppression | 29.74 | 13.67 | 20 | 86720 | 1470 | 70840234 |
Red cell distribution width increased | 29.68 | 13.67 | 57 | 86683 | 13600 | 70828104 |
Depressed level of consciousness | 29.64 | 13.67 | 38 | 86702 | 87393 | 70754311 |
Hepatic lesion | 29.63 | 13.67 | 37 | 86703 | 6080 | 70835624 |
Systolic dysfunction | 29.14 | 13.67 | 28 | 86712 | 3433 | 70838271 |
Diabetes mellitus | 29.01 | 13.67 | 27 | 86713 | 71797 | 70769907 |
Tachycardia | 28.98 | 13.67 | 309 | 86431 | 158237 | 70683467 |
Enterocolitis infectious | 28.96 | 13.67 | 25 | 86715 | 2669 | 70839035 |
Glossodynia | 28.90 | 13.67 | 38 | 86702 | 86449 | 70755255 |
Anxiety | 28.82 | 13.67 | 155 | 86585 | 220175 | 70621529 |
Renal failure | 28.79 | 13.67 | 126 | 86614 | 188944 | 70652760 |
Onychomadesis | 28.68 | 13.67 | 30 | 86710 | 4071 | 70837633 |
Medication error | 28.65 | 13.67 | 17 | 86723 | 56895 | 70784809 |
Anastomotic complication | 28.63 | 13.67 | 13 | 86727 | 438 | 70841266 |
Lung infiltration | 28.61 | 13.67 | 74 | 86666 | 21550 | 70820154 |
Pulmonary embolism | 28.59 | 13.67 | 304 | 86436 | 155563 | 70686141 |
Hepatic function abnormal | 28.56 | 13.67 | 161 | 86579 | 67835 | 70773869 |
Irritability | 28.44 | 13.67 | 6 | 86734 | 38219 | 70803485 |
Suicidal ideation | 28.30 | 13.67 | 26 | 86714 | 69570 | 70772134 |
Nasal discomfort | 28.14 | 13.67 | 32 | 86708 | 4769 | 70836935 |
Odynophagia | 27.91 | 13.67 | 47 | 86693 | 10128 | 70831576 |
Breast inflammation | 27.90 | 13.67 | 9 | 86731 | 115 | 70841589 |
Excessive eye blinking | 27.87 | 13.67 | 19 | 86721 | 1428 | 70840276 |
Vessel puncture site bruise | 27.68 | 13.67 | 13 | 86727 | 474 | 70841230 |
Osteoarthritis | 27.51 | 13.67 | 30 | 86710 | 74117 | 70767587 |
Tumour marker abnormal | 27.47 | 13.67 | 11 | 86729 | 270 | 70841434 |
Biliary sepsis | 27.28 | 13.67 | 19 | 86721 | 1479 | 70840225 |
Keratitis | 27.20 | 13.67 | 28 | 86712 | 3729 | 70837975 |
Blister | 27.09 | 13.67 | 51 | 86689 | 100475 | 70741229 |
Metastases to pleura | 27.05 | 13.67 | 18 | 86722 | 1300 | 70840404 |
Dysarthria | 26.89 | 13.67 | 22 | 86718 | 62291 | 70779413 |
Disorientation | 26.85 | 13.67 | 19 | 86721 | 57904 | 70783800 |
Abnormal behaviour | 26.76 | 13.67 | 5 | 86735 | 34704 | 70807000 |
Hydrothorax | 26.58 | 13.67 | 18 | 86722 | 1338 | 70840366 |
Wrong technique in product usage process | 26.38 | 13.67 | 27 | 86713 | 68671 | 70773033 |
Nasal disorder | 26.38 | 13.67 | 26 | 86714 | 3288 | 70838416 |
Carcinoembryonic antigen increased | 26.33 | 13.67 | 21 | 86719 | 2009 | 70839695 |
Death | 26.12 | 13.67 | 812 | 85928 | 509249 | 70332455 |
Neoplasm recurrence | 26.09 | 13.67 | 28 | 86712 | 3913 | 70837791 |
Papilloedema | 26.03 | 13.67 | 34 | 86706 | 5844 | 70835860 |
Blood creatine phosphokinase increased | 25.98 | 13.67 | 22 | 86718 | 61241 | 70780463 |
Performance status decreased | 25.74 | 13.67 | 33 | 86707 | 5568 | 70836136 |
Osteosclerosis | 25.73 | 13.67 | 27 | 86713 | 3678 | 70838026 |
Breast cellulitis | 25.70 | 13.67 | 11 | 86729 | 321 | 70841383 |
Therapy cessation | 25.65 | 13.67 | 5 | 86735 | 33671 | 70808033 |
Vulvovaginal candidiasis | 25.53 | 13.67 | 22 | 86718 | 2344 | 70839360 |
Metabolic acidosis | 25.52 | 13.67 | 32 | 86708 | 74314 | 70767390 |
Gait disturbance | 25.45 | 13.67 | 128 | 86612 | 184978 | 70656726 |
Bone lesion | 24.97 | 13.67 | 32 | 86708 | 5398 | 70836306 |
Treatment noncompliance | 24.76 | 13.67 | 13 | 86727 | 46561 | 70795143 |
Hepatotoxicity | 24.69 | 13.67 | 113 | 86627 | 43873 | 70797831 |
Calcium ionised increased | 24.62 | 13.67 | 9 | 86731 | 171 | 70841533 |
Multicentric reticulohistiocytosis | 24.60 | 13.67 | 5 | 86735 | 6 | 70841698 |
Vulvovaginal inflammation | 24.52 | 13.67 | 12 | 86728 | 480 | 70841224 |
Skin fissures | 24.45 | 13.67 | 47 | 86693 | 11223 | 70830481 |
Nail bed bleeding | 24.40 | 13.67 | 12 | 86728 | 485 | 70841219 |
Ear infection | 24.32 | 13.67 | 3 | 86737 | 28333 | 70813371 |
Nephrolithiasis | 24.02 | 13.67 | 14 | 86726 | 47309 | 70794395 |
Pustule | 23.91 | 13.67 | 18 | 86722 | 1581 | 70840123 |
Peripheral motor neuropathy | 23.88 | 13.67 | 24 | 86716 | 3108 | 70838596 |
Off label use | 23.76 | 13.67 | 1123 | 85617 | 741937 | 70099767 |
Basal cell carcinoma | 23.66 | 13.67 | 6 | 86734 | 33692 | 70808012 |
Back pain | 23.59 | 13.67 | 464 | 86276 | 270688 | 70571016 |
Emotional distress | 23.58 | 13.67 | 8 | 86732 | 37180 | 70804524 |
Post-traumatic pain | 23.45 | 13.67 | 11 | 86729 | 400 | 70841304 |
Osteitis condensans | 23.37 | 13.67 | 6 | 86734 | 31 | 70841673 |
Sensory disturbance | 23.32 | 13.67 | 52 | 86688 | 13780 | 70827924 |
Acute pulmonary oedema | 23.27 | 13.67 | 51 | 86689 | 13361 | 70828343 |
Exposure during pregnancy | 23.20 | 13.67 | 45 | 86695 | 87672 | 70754032 |
Irritable bowel syndrome | 23.15 | 13.67 | 17 | 86723 | 50833 | 70790871 |
Renal impairment | 23.09 | 13.67 | 94 | 86646 | 143843 | 70697861 |
Sopor | 23.07 | 13.67 | 5 | 86735 | 31262 | 70810442 |
Subdural haematoma | 23.07 | 13.67 | 4 | 86736 | 29294 | 70812410 |
HER2 positive gastric cancer | 22.83 | 13.67 | 4 | 86736 | 0 | 70841704 |
Cerebrovascular accident | 22.83 | 13.67 | 94 | 86646 | 143376 | 70698328 |
Cystoid macular oedema | 22.80 | 13.67 | 19 | 86721 | 1933 | 70839771 |
Hyperbilirubinaemia | 22.76 | 13.67 | 70 | 86670 | 22498 | 70819206 |
Osteoporosis | 22.72 | 13.67 | 16 | 86724 | 48891 | 70792813 |
Gait inability | 22.50 | 13.67 | 15 | 86725 | 47160 | 70794544 |
Dyspepsia | 22.48 | 13.67 | 186 | 86554 | 88891 | 70752813 |
Temperature intolerance | 22.23 | 13.67 | 39 | 86701 | 8684 | 70833020 |
Dysaesthesia | 22.15 | 13.67 | 30 | 86710 | 5338 | 70836366 |
Xerophthalmia | 22.08 | 13.67 | 12 | 86728 | 598 | 70841106 |
Lymphangitis | 22.00 | 13.67 | 16 | 86724 | 1333 | 70840371 |
Palmar erythema | 22.00 | 13.67 | 18 | 86722 | 1785 | 70839919 |
Migraine | 21.89 | 13.67 | 34 | 86706 | 72204 | 70769500 |
Influenza | 21.73 | 13.67 | 69 | 86671 | 113631 | 70728073 |
Urticaria | 21.70 | 13.67 | 114 | 86626 | 162935 | 70678769 |
Osteolysis | 21.55 | 13.67 | 24 | 86716 | 3495 | 70838209 |
Pneumonia aspiration | 21.18 | 13.67 | 27 | 86713 | 62262 | 70779442 |
Rash pustular | 21.16 | 13.67 | 42 | 86698 | 10266 | 70831438 |
Blood alkaline phosphatase increased | 21.01 | 13.67 | 133 | 86607 | 58388 | 70783316 |
Left ventricular dilatation | 21.00 | 13.67 | 14 | 86726 | 1014 | 70840690 |
Corneal disorder | 20.99 | 13.67 | 19 | 86721 | 2160 | 70839544 |
Gait apraxia | 20.93 | 13.67 | 5 | 86735 | 18 | 70841686 |
Distichiasis | 20.93 | 13.67 | 5 | 86735 | 18 | 70841686 |
Lymphadenopathy | 20.80 | 13.67 | 116 | 86624 | 48675 | 70793029 |
Breast disorder | 20.78 | 13.67 | 18 | 86722 | 1931 | 70839773 |
Radiation pneumonitis | 20.61 | 13.67 | 24 | 86716 | 3669 | 70838035 |
Pulmonary hypoplasia | 20.60 | 13.67 | 6 | 86734 | 53 | 70841651 |
Overflow diarrhoea | 20.55 | 13.67 | 7 | 86733 | 107 | 70841597 |
Respiratory depression | 20.43 | 13.67 | 3 | 86737 | 24828 | 70816876 |
Acute respiratory distress syndrome | 20.27 | 13.67 | 102 | 86638 | 41152 | 70800552 |
Pericarditis | 20.27 | 13.67 | 46 | 86694 | 84659 | 70757045 |
Barotrauma | 20.22 | 13.67 | 8 | 86732 | 190 | 70841514 |
Swollen tongue | 20.20 | 13.67 | 10 | 86730 | 37036 | 70804668 |
Hypothalamo-pituitary disorder | 20.20 | 13.67 | 14 | 86726 | 1081 | 70840623 |
Spinal pain | 20.18 | 13.67 | 49 | 86691 | 13721 | 70827983 |
Infection | 20.12 | 13.67 | 163 | 86577 | 210622 | 70631082 |
Delusion of grandeur | 20.11 | 13.67 | 13 | 86727 | 894 | 70840810 |
Dermatomyositis | 20.09 | 13.67 | 23 | 86717 | 3452 | 70838252 |
Breast sarcoma | 20.06 | 13.67 | 4 | 86736 | 4 | 70841700 |
Vaginal prolapse | 20.05 | 13.67 | 9 | 86731 | 295 | 70841409 |
Dizziness | 20.05 | 13.67 | 424 | 86316 | 463717 | 70377987 |
Ovarian failure | 19.90 | 13.67 | 11 | 86729 | 567 | 70841137 |
Mouth ulceration | 19.84 | 13.67 | 89 | 86651 | 34260 | 70807444 |
Hypervolaemia | 19.79 | 13.67 | 12 | 86728 | 39694 | 70802010 |
Acute myocardial infarction | 19.62 | 13.67 | 37 | 86703 | 72850 | 70768854 |
Dysuria | 19.61 | 13.67 | 109 | 86631 | 45685 | 70796019 |
Subclavian vein thrombosis | 19.60 | 13.67 | 19 | 86721 | 2355 | 70839349 |
Hyperchlorhydria | 19.58 | 13.67 | 17 | 86723 | 1829 | 70839875 |
Haemorrhoids | 19.30 | 13.67 | 72 | 86668 | 25516 | 70816188 |
Tidal volume decreased | 19.18 | 13.67 | 6 | 86734 | 69 | 70841635 |
Skin infection | 19.15 | 13.67 | 53 | 86687 | 16059 | 70825645 |
Hypotension | 19.08 | 13.67 | 364 | 86376 | 404017 | 70437687 |
Agitation | 19.03 | 13.67 | 55 | 86685 | 93320 | 70748384 |
Gastritis | 19.00 | 13.67 | 106 | 86634 | 44485 | 70797219 |
Herpangina | 18.99 | 13.67 | 5 | 86735 | 29 | 70841675 |
Inflammatory carcinoma of the breast | 18.99 | 13.67 | 5 | 86735 | 29 | 70841675 |
Impaired healing | 18.94 | 13.67 | 39 | 86701 | 74335 | 70767369 |
Eye pain | 18.91 | 13.67 | 9 | 86731 | 34093 | 70807611 |
Merycism | 18.67 | 13.67 | 8 | 86732 | 234 | 70841470 |
Transaminases | 18.58 | 13.67 | 6 | 86734 | 77 | 70841627 |
Gastrointestinal disorder | 18.57 | 13.67 | 204 | 86536 | 105223 | 70736481 |
Thrombocytopenia | 18.43 | 13.67 | 402 | 86338 | 238708 | 70602996 |
Blood creatine increased | 18.34 | 13.67 | 36 | 86704 | 8728 | 70832976 |
Therapy interrupted | 18.23 | 13.67 | 4 | 86736 | 24798 | 70816906 |
Entropion | 18.06 | 13.67 | 5 | 86735 | 36 | 70841668 |
Nail bed tenderness | 18.05 | 13.67 | 9 | 86731 | 375 | 70841329 |
Toxic neuropathy | 18.04 | 13.67 | 12 | 86728 | 866 | 70840838 |
Cataract | 18.03 | 13.67 | 25 | 86715 | 55620 | 70786084 |
Retinal detachment | 17.99 | 13.67 | 35 | 86705 | 8432 | 70833272 |
Vocal cord paralysis | 17.96 | 13.67 | 18 | 86722 | 2323 | 70839381 |
Sarcoid-like reaction | 17.83 | 13.67 | 4 | 86736 | 10 | 70841694 |
Encephalopathy | 17.77 | 13.67 | 30 | 86710 | 61631 | 70780073 |
Metastases to the mediastinum | 17.77 | 13.67 | 10 | 86730 | 534 | 70841170 |
Urinary retention | 17.62 | 13.67 | 23 | 86717 | 52497 | 70789207 |
Metastases to breast | 17.55 | 13.67 | 8 | 86732 | 272 | 70841432 |
Maternal exposure during pregnancy | 17.47 | 13.67 | 77 | 86663 | 115268 | 70726436 |
Eastern Cooperative Oncology Group performance status worsened | 17.45 | 13.67 | 15 | 86725 | 1593 | 70840111 |
Device issue | 17.41 | 13.67 | 4 | 86736 | 24021 | 70817683 |
Pituitary tumour | 17.31 | 13.67 | 13 | 86727 | 1138 | 70840566 |
Limb injury | 17.30 | 13.67 | 5 | 86735 | 25747 | 70815957 |
Colitis ulcerative | 17.26 | 13.67 | 10 | 86730 | 33913 | 70807791 |
Lower respiratory tract infection | 17.23 | 13.67 | 211 | 86529 | 111702 | 70730002 |
Leukaemia cutis | 17.18 | 13.67 | 7 | 86733 | 180 | 70841524 |
Globulinuria | 17.12 | 13.67 | 3 | 86737 | 0 | 70841704 |
Left atrial volume increased | 17.12 | 13.67 | 3 | 86737 | 0 | 70841704 |
Tooth extraction | 17.04 | 13.67 | 38 | 86702 | 10069 | 70831635 |
Malignant pleural effusion | 16.85 | 13.67 | 20 | 86720 | 3119 | 70838585 |
Dandy-Walker syndrome | 16.79 | 13.67 | 5 | 86735 | 48 | 70841656 |
Illness | 16.71 | 13.67 | 9 | 86731 | 31782 | 70809922 |
Aphasia | 16.60 | 13.67 | 17 | 86723 | 43232 | 70798472 |
Transient ischaemic attack | 16.59 | 13.67 | 19 | 86721 | 45925 | 70795779 |
Road traffic accident | 16.57 | 13.67 | 11 | 86729 | 34671 | 70807033 |
Tongue coated | 16.56 | 13.67 | 13 | 86727 | 1215 | 70840489 |
Axillary vein thrombosis | 16.52 | 13.67 | 10 | 86730 | 612 | 70841092 |
Clostridial infection | 16.50 | 13.67 | 26 | 86714 | 5303 | 70836401 |
Adenocarcinoma gastric | 16.45 | 13.67 | 15 | 86725 | 1721 | 70839983 |
Catheter site pain | 16.44 | 13.67 | 25 | 86715 | 4943 | 70836761 |
Generalised tonic-clonic seizure | 16.42 | 13.67 | 16 | 86724 | 41645 | 70800059 |
Pleural disorder | 16.39 | 13.67 | 11 | 86729 | 806 | 70840898 |
Metastases to nervous system | 16.35 | 13.67 | 5 | 86735 | 53 | 70841651 |
Breast ulceration | 16.35 | 13.67 | 5 | 86735 | 53 | 70841651 |
Gout | 16.34 | 13.67 | 4 | 86736 | 23002 | 70818702 |
Adverse drug reaction | 16.27 | 13.67 | 25 | 86715 | 53319 | 70788385 |
Oral candidiasis | 16.22 | 13.67 | 67 | 86673 | 24885 | 70816819 |
Spider naevus | 16.17 | 13.67 | 6 | 86734 | 119 | 70841585 |
Alopecia totalis | 16.12 | 13.67 | 8 | 86732 | 330 | 70841374 |
Angioedema | 16.07 | 13.67 | 36 | 86704 | 66574 | 70775130 |
Viral infection | 16.02 | 13.67 | 14 | 86726 | 38377 | 70803327 |
Naevus haemorrhage | 15.99 | 13.67 | 6 | 86734 | 123 | 70841581 |
Paralysis recurrent laryngeal nerve | 15.99 | 13.67 | 6 | 86734 | 123 | 70841581 |
Nasal ulcer | 15.90 | 13.67 | 15 | 86725 | 1798 | 70839906 |
Urinary tract disorder | 15.87 | 13.67 | 20 | 86720 | 3317 | 70838387 |
Foot deformity | 15.87 | 13.67 | 3 | 86737 | 20652 | 70821052 |
Botryomycosis | 15.86 | 13.67 | 5 | 86735 | 59 | 70841645 |
Full blood count abnormal | 15.85 | 13.67 | 11 | 86729 | 33867 | 70807837 |
Pancreatitis | 15.84 | 13.67 | 33 | 86707 | 62635 | 70779069 |
Hypoxia | 15.70 | 13.67 | 179 | 86561 | 93165 | 70748539 |
Gingival pain | 15.67 | 13.67 | 29 | 86711 | 6728 | 70834976 |
Movement disorder | 15.64 | 13.67 | 5 | 86735 | 24124 | 70817580 |
Pneumonitis chemical | 15.56 | 13.67 | 8 | 86732 | 356 | 70841348 |
Dental fistula | 15.53 | 13.67 | 9 | 86731 | 508 | 70841196 |
Urogenital prolapse | 15.53 | 13.67 | 4 | 86736 | 21 | 70841683 |
Pleural neoplasm | 15.45 | 13.67 | 8 | 86732 | 361 | 70841343 |
Gastric disorder | 15.35 | 13.67 | 11 | 86729 | 33311 | 70808393 |
Injection site haemorrhage | 15.33 | 13.67 | 6 | 86734 | 25521 | 70816183 |
Gastric perforation | 15.26 | 13.67 | 21 | 86719 | 3794 | 70837910 |
Amenorrhoea | 15.15 | 13.67 | 29 | 86711 | 6901 | 70834803 |
Joint injury | 15.10 | 13.67 | 7 | 86733 | 26925 | 70814779 |
Myeloproliferative neoplasm | 15.08 | 13.67 | 11 | 86729 | 921 | 70840783 |
Diabetic ketoacidosis | 15.05 | 13.67 | 10 | 86730 | 31502 | 70810202 |
Atrial thrombosis | 14.82 | 13.67 | 19 | 86721 | 3206 | 70838498 |
Fluid retention | 14.70 | 13.67 | 35 | 86705 | 63350 | 70778354 |
Hepatitis | 14.69 | 13.67 | 24 | 86716 | 49956 | 70791748 |
Flatulence | 14.67 | 13.67 | 15 | 86725 | 38166 | 70803538 |
Product administration error | 14.61 | 13.67 | 9 | 86731 | 29514 | 70812190 |
Incorrect dose administered | 14.57 | 13.67 | 38 | 86702 | 66681 | 70775023 |
Myoclonus | 14.55 | 13.67 | 7 | 86733 | 26348 | 70815356 |
Carbohydrate antigen 19-9 increased | 14.53 | 13.67 | 8 | 86732 | 409 | 70841295 |
Postural orthostatic tachycardia syndrome | 14.45 | 13.67 | 9 | 86731 | 580 | 70841124 |
Corneal bleeding | 14.43 | 13.67 | 4 | 86736 | 29 | 70841675 |
Frequent bowel movements | 14.40 | 13.67 | 4 | 86736 | 21149 | 70820555 |
Rhinorrhoea | 14.36 | 13.67 | 134 | 86606 | 66237 | 70775467 |
Hypertensive crisis | 14.36 | 13.67 | 54 | 86686 | 19208 | 70822496 |
Pulmonary toxicity | 14.33 | 13.67 | 37 | 86703 | 10761 | 70830943 |
Chromosomal mutation | 14.31 | 13.67 | 4 | 86736 | 30 | 70841674 |
Appendiceal abscess | 14.23 | 13.67 | 7 | 86733 | 283 | 70841421 |
Product quality issue | 14.19 | 13.67 | 10 | 86730 | 30551 | 70811153 |
Tumour haemorrhage | 14.16 | 13.67 | 20 | 86720 | 3702 | 70838002 |
Folate deficiency | 14.16 | 13.67 | 18 | 86722 | 3012 | 70838692 |
Fear | 14.05 | 13.67 | 4 | 86736 | 20807 | 70820897 |
Toothache | 14.02 | 13.67 | 52 | 86688 | 18378 | 70823326 |
Bronchitis | 13.96 | 13.67 | 85 | 86655 | 117158 | 70724546 |
Labelled drug-drug interaction medication error | 13.95 | 13.67 | 6 | 86734 | 24121 | 70817583 |
Nodular regenerative hyperplasia | 13.90 | 13.67 | 12 | 86728 | 1281 | 70840423 |
Lymphocyte count decreased | 13.84 | 13.67 | 96 | 86644 | 43443 | 70798261 |
HER2 positive salivary gland cancer | 13.84 | 13.67 | 3 | 86737 | 6 | 70841698 |
Catheter site bruise | 13.83 | 13.67 | 7 | 86733 | 301 | 70841403 |
Mouth swelling | 13.74 | 13.67 | 24 | 86716 | 5325 | 70836379 |
Plantar erythema | 13.73 | 13.67 | 7 | 86733 | 306 | 70841398 |
None
Source | Code | Description |
---|---|---|
ATC | L01FD01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors |
ATC | L01XY02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Combinations of antineoplastic agents |
FDA MoA | N0000020008 | HER2/Neu/cerbB2 Antagonists |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000074322 | Antineoplastic Agents, Immunological |
FDA EPC | N0000175661 | HER2/neu Receptor Antagonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Secondary malignant neoplasm of female breast | indication | 94297009 | |
Secondary malignant neoplasm of stomach | indication | 94606003 | |
Human epidermal growth factor 2 positive gastric cancer | indication | 102453009 | |
HER2-positive salivary gland tumors | indication | 255072001 | |
HER2-positive rectal cancer | indication | 363351006 | DOID:1993 |
HER2-positive colon cancer | indication | 363406005 | DOID:219 |
HER2-positive carcinoma of breast | indication | 427685000 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Receptor tyrosine-protein kinase erbB-2 | Kinase | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
ID | Source |
---|---|
P188ANX8CK | UNII |
D03257 | KEGG_DRUG |
4021140 | VUID |
N0000148593 | NUI |
C0728747 | UMLSCUI |
CHEMBL1201585 | ChEMBL_ID |
DB00072 | DRUGBANK_ID |
D000068878 | MESH_DESCRIPTOR_UI |
7637 | INN_ID |
C000630669 | MESH_SUPPLEMENTAL_RECORD_UI |
5082 | IUPHAR_LIGAND_ID |
101306 | RXNORM |
11893 | MMSL |
266775 | MMSL |
33398 | MMSL |
7554 | MMSL |
d04357 | MMSL |
007663 | NDDF |
017423 | NDDF |
327397006 | SNOMEDCT_US |
387003001 | SNOMEDCT_US |
4021140 | VANDF |
4038908 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ontruzant | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-5033 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
Trazimera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0308 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
Herceptin Hylecta | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50242-077 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 28 sections |
Herceptin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 25 sections |
Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-245 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-245 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-260 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-260 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 28 sections |
Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 28 sections |
Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-141 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-141 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
HERZUMA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63459-303 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
HERZUMA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63459-303 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
OGIVRI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-845 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 29 sections |
OGIVRI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-991 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
Ontruzant | HUMAN PRESCRIPTION DRUG LABEL | 1 | 78206-147 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |