etanercept 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Tumour Necrosis Factor (TNF) receptors 4978 185243-69-0

Description:

MoleculeDescription

Synonyms:

  • etanercept-szzs
  • erelzi
  • etanercept
  • enbrel
  • TNR 001
  • TNR-001
  • etanercept (genetical recombination)
A recombinant version of soluble human TNF receptor fused to an IgG FC fragment that binds specifically to TUMOR NECROSIS FACTOR and inhibits its binding with endogenous TNF receptors. It prevents the inflammatory effect of TNF and is used to treat RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS and ANKYLOSING SPONDYLITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
7 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 3, 2000 EMA
Nov. 2, 1998 FDA IMMUNEX
Jan. 19, 2005 PMDA WYETH LEDERLE JAPAN, WYETH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site erythema 40081.01 13.57 21479 980092 61695 62425756
Injection site pain 39179.79 13.57 24727 976844 105073 62382378
Injection site pruritus 22445.77 13.57 11919 989652 33197 62454254
Injection site swelling 21359.43 13.57 11741 989830 35831 62451620
Injection site reaction 16654.77 13.57 10768 990803 47756 62439695
Injection site bruising 13179.40 13.57 8217 993354 33693 62453758
Injection site warmth 11831.93 13.57 5451 996120 9744 62477707
Drug ineffective 9031.56 13.57 36285 965286 1008480 61478971
Injection site rash 6664.36 13.57 3983 997588 14826 62472625
Arthralgia 5975.37 13.57 21107 980464 548603 61938848
Injection site urticaria 5535.29 13.57 3189 998382 10884 62476567
Wrong technique in product usage process 5507.04 13.57 5811 995760 56529 62430922
Injection site haemorrhage 5354.33 13.57 3822 997749 20492 62466959
Joint swelling 3870.29 13.57 12652 988919 315014 62172437
Therapeutic product effect decreased 3724.42 13.57 8920 992651 184267 62303184
Injection site discolouration 3400.42 13.57 1895 999676 5953 62481498
Injection site induration 3242.05 13.57 1944 999627 7282 62480169
Therapeutic product effect incomplete 3117.92 13.57 6403 995168 118653 62368798
Pain in extremity 3018.03 13.57 11756 989815 319730 62167721
Acute kidney injury 2830.97 13.57 398 1001173 263017 62224434
Toxicity to various agents 2766.80 13.57 328 1001243 246922 62240529
Product storage error 2639.23 13.57 2059 999512 12897 62474554
Hypotension 2620.23 13.57 553 1001018 272051 62215400
Pain 2619.81 13.57 20272 981299 720356 61767095
Death 2579.96 13.57 1346 1000225 373035 62114416
Drug interaction 2570.97 13.57 301 1001270 228830 62258621
Accidental exposure to product 2515.47 13.57 2609 998962 24796 62462655
Nasopharyngitis 2324.01 13.57 9033 992538 245224 62242227
Anaemia 2221.35 13.57 925 1000646 292505 62194946
Completed suicide 2220.40 13.57 13 1001558 145660 62341791
Device issue 2213.23 13.57 2281 999290 21500 62465951
Sinusitis 2159.10 13.57 8160 993411 218493 62268958
Treatment failure 2034.53 13.57 7332 994239 191711 62295740
Injection site mass 2008.49 13.57 1937 999634 16719 62470732
Musculoskeletal stiffness 1840.17 13.57 6746 994825 177872 62309579
Febrile neutropenia 1676.50 13.57 40 1001531 118409 62369042
Dyspnoea 1673.87 13.57 5132 996439 656181 61831270
Constipation 1671.42 13.57 728 1000843 224215 62263236
Swelling 1596.95 13.57 8557 993014 266821 62220630
Mobility decreased 1568.80 13.57 4836 996735 116323 62371128
Contraindicated product administered 1557.36 13.57 7180 994391 210468 62276983
Hyponatraemia 1497.10 13.57 62 1001509 111838 62375613
Drug intolerance 1490.86 13.57 9135 992436 299526 62187925
Diarrhoea 1487.98 13.57 6033 995538 709333 61778118
Neutropenia 1457.72 13.57 472 1001099 174533 62312918
Product dose omission issue 1412.66 13.57 7361 994210 226952 62260499
Therapeutic response decreased 1345.63 13.57 2989 998582 58536 62428915
Thrombocytopenia 1330.93 13.57 368 1001203 150789 62336662
Dehydration 1327.67 13.57 536 1001035 172818 62314633
Abdominal pain 1301.40 13.57 1631 999940 291825 62195626
Injection site haematoma 1298.12 13.57 983 1000588 5849 62481602
Injection site discomfort 1243.58 13.57 823 1000748 3807 62483644
Malignant neoplasm progression 1242.60 13.57 9 1001562 82112 62405339
Disease progression 1203.17 13.57 237 1001334 122521 62364930
Musculoskeletal pain 1192.94 13.57 3682 997889 88595 62398856
Vomiting 1138.14 13.57 4757 996814 554860 61932591
Joint stiffness 1128.08 13.57 2216 999355 39653 62447798
Arthropathy 1120.53 13.57 6930 994641 227862 62259589
Cardiac arrest 1106.31 13.57 95 1001476 92450 62395001
Seizure 1086.28 13.57 368 1001203 132266 62355185
Intentional overdose 1069.07 13.57 20 1001551 74132 62413319
Tachycardia 1067.80 13.57 273 1001298 117883 62369568
Synovitis 1043.33 13.57 5751 995820 181167 62306284
Hypokalaemia 1030.78 13.57 194 1001377 103610 62383841
Haemoglobin decreased 989.86 13.57 530 1001041 144955 62342496
Bradycardia 984.67 13.57 39 1001532 73188 62414263
Drug abuse 980.66 13.57 37 1001534 72481 62414970
Somnolence 962.62 13.57 841 1000730 177844 62309607
Therapy interrupted 940.82 13.57 1772 999799 30683 62456768
Pancytopenia 927.30 13.57 198 1001373 96735 62390716
Underdose 927.18 13.57 1602 999969 25854 62461597
Peripheral swelling 903.33 13.57 7227 994344 258715 62228736
Oxygen saturation decreased 902.40 13.57 155 1001416 88430 62399021
Electrocardiogram QT prolonged 893.43 13.57 8 1001563 59522 62427929
Pulmonary embolism 873.39 13.57 373 1001198 116311 62371140
Respiratory failure 865.15 13.57 265 1001306 101593 62385858
Nausea 837.55 13.57 9041 992530 845430 61642021
Arthritis 832.06 13.57 3830 997741 112091 62375360
Overdose 808.35 13.57 402 1001169 114676 62372775
Injection site recall reaction 805.95 13.57 287 1001284 126 62487325
Renal failure 804.08 13.57 426 1001145 117226 62370225
Depressed level of consciousness 796.14 13.57 45 1001526 62033 62425418
Gastrointestinal haemorrhage 790.52 13.57 159 1001412 81017 62406434
Injection site macule 789.90 13.57 303 1001268 233 62487218
Musculoskeletal disorder 785.81 13.57 1271 1000300 19373 62468078
Platelet count decreased 785.48 13.57 426 1001145 115696 62371755
Hyperkalaemia 767.94 13.57 18 1001553 54185 62433266
Suicide attempt 766.60 13.57 49 1001522 60869 62426582
Injection site extravasation 761.68 13.57 814 1000757 8027 62479424
Respiratory tract congestion 745.33 13.57 1146 1000425 16686 62470765
Decreased appetite 739.42 13.57 1805 999766 249247 62238204
Infection 735.86 13.57 6150 995421 223023 62264428
Hypoxia 735.19 13.57 54 1001517 59738 62427713
Cardio-respiratory arrest 731.98 13.57 56 1001515 59903 62427548
Syncope 727.39 13.57 478 1001093 116907 62370544
Multiple sclerosis relapse 716.07 13.57 9 1001562 48469 62438982
Product use in unapproved indication 705.21 13.57 1083 1000488 177997 62309454
Deep vein thrombosis 695.63 13.57 227 1001344 83573 62403878
Asthenia 690.22 13.57 3408 998163 380196 62107255
Drug hypersensitivity 685.33 13.57 7704 993867 302983 62184468
Hypoglycaemia 685.25 13.57 74 1001497 59991 62427460
Atrial fibrillation 684.23 13.57 504 1001067 116132 62371319
Weight decreased 678.84 13.57 2174 999397 274624 62212827
Coma 674.81 13.57 104 1001467 64260 62423191
Agitation 673.19 13.57 77 1001494 59680 62427771
Sepsis 666.56 13.57 862 1000709 152261 62335190
Knee arthroplasty 655.27 13.57 2114 999457 52092 62435359
Finger deformity 651.25 13.57 704 1000867 7041 62480410
Neutrophil count decreased 639.66 13.57 71 1001500 56335 62431116
Tremor 632.60 13.57 691 1000880 131548 62355903
Surgery 631.35 13.57 1603 999968 34309 62453142
Cardiac failure 626.59 13.57 311 1001260 88831 62398620
International normalised ratio increased 623.19 13.57 25 1001546 46400 62441051
Injection site irritation 618.74 13.57 560 1001011 4418 62483033
Blood pressure increased 600.53 13.57 1020 1000551 161042 62326409
Rhabdomyolysis 599.14 13.57 21 1001550 43930 62443521
Injury associated with device 591.60 13.57 479 1001092 3187 62484264
Fear of injection 588.09 13.57 643 1000928 6521 62480930
Blood pressure decreased 587.76 13.57 150 1001421 64872 62422579
Condition aggravated 586.39 13.57 9251 992320 392966 62094485
Metabolic acidosis 583.10 13.57 31 1001540 45038 62442413
Dizziness 581.09 13.57 4183 997388 425742 62061709
Lactic acidosis 575.21 13.57 5 1001566 38282 62449169
Pleural effusion 572.78 13.57 383 1001188 92827 62394624
Nodule 570.03 13.57 1116 1000455 19910 62467541
Hallucination 569.17 13.57 91 1001480 54726 62432725
Sedation 549.33 13.57 13 1001558 38796 62448655
Red blood cell sedimentation rate abnormal 544.85 13.57 1057 1000514 18725 62468726
Anxiety 543.37 13.57 1694 999877 215847 62271604
Therapy non-responder 541.57 13.57 2504 999067 73397 62414054
Heart rate increased 541.41 13.57 416 1001155 93822 62393629
Psoriasis 540.91 13.57 2758 998813 84199 62403252
Pulmonary oedema 533.15 13.57 108 1001463 54765 62432686
White blood cell count decreased 529.72 13.57 860 1000711 138244 62349207
Exposure during pregnancy 528.11 13.57 1033 1000538 154514 62332937
Device expulsion 527.36 13.57 4 1001567 34918 62452533
Incorrect dose administered by device 524.52 13.57 481 1001090 3867 62483584
Neoplasm progression 524.32 13.57 10 1001561 36418 62451033
Fall 522.40 13.57 3833 997738 388501 62098950
Injection site vesicles 521.08 13.57 408 1001163 2569 62484882
Cardiac failure congestive 519.70 13.57 417 1001154 92016 62395435
Alopecia 506.67 13.57 7803 993768 329733 62157718
C-reactive protein abnormal 504.90 13.57 1739 999832 44357 62443094
Skin plaque 503.78 13.57 639 1000932 7681 62479770
Hypersensitivity 502.30 13.57 6926 994645 285759 62201692
Confusional state 500.29 13.57 1975 999596 234405 62253046
Multiple organ dysfunction syndrome 493.95 13.57 141 1001430 56611 62430840
Neuropathy peripheral 486.25 13.57 648 1000923 113019 62374432
Injection site inflammation 478.98 13.57 433 1001138 3410 62484041
Suicidal ideation 471.03 13.57 197 1001374 62224 62425227
Mental status changes 469.48 13.57 42 1001529 39557 62447894
Blood creatinine increased 462.48 13.57 422 1001149 87422 62400029
Drug dose omission by device 461.95 13.57 469 1001102 4332 62483119
Hyperglycaemia 461.57 13.57 58 1001513 41809 62445642
Chest pain 457.19 13.57 1804 999767 214155 62273296
Orthostatic hypotension 455.19 13.57 29 1001542 36131 62451320
Oropharyngeal pain 452.93 13.57 2794 998777 91693 62395758
Ascites 452.49 13.57 55 1001516 40673 62446778
Hand deformity 451.02 13.57 4163 997408 155294 62332157
Blood bilirubin increased 449.63 13.57 36 1001535 37104 62450347
Dyspnoea exertional 445.96 13.57 196 1001375 60106 62427345
Bronchitis 444.08 13.57 3433 998138 121502 62365949
Encephalopathy 441.99 13.57 47 1001524 38573 62448878
Mucosal inflammation 430.44 13.57 105 1001466 46823 62440628
Influenza 426.96 13.57 3059 998512 105663 62381788
Drug reaction with eosinophilia and systemic symptoms 426.34 13.57 27 1001544 33809 62453642
Unresponsive to stimuli 426.04 13.57 27 1001544 33789 62453662
Respiratory arrest 423.74 13.57 22 1001549 32623 62454828
Dysarthria 415.07 13.57 84 1001487 42627 62444824
Inflammation 412.18 13.57 2461 999110 79812 62407639
Haematochezia 412.10 13.57 164 1001407 53380 62434071
Foetal exposure during pregnancy 410.32 13.57 23 1001548 31939 62455512
Flushing 409.39 13.57 349 1001222 74738 62412713
Serotonin syndrome 408.31 13.57 9 1001562 28673 62458778
Cerebrovascular accident 408.27 13.57 671 1000900 107353 62380098
Systemic lupus erythematosus 401.53 13.57 5048 996523 203870 62283581
Transplant dysfunction 401.16 13.57 438 1001133 4434 62483017
Blood pressure systolic increased 399.32 13.57 125 1001446 47272 62440179
Cognitive disorder 397.86 13.57 191 1001380 55624 62431827
Foot deformity 393.20 13.57 1147 1000424 26706 62460745
Adverse reaction 388.03 13.57 628 1000943 9575 62477876
Palpitations 385.20 13.57 746 1000825 112024 62375427
Paranasal sinus hypersecretion 384.02 13.57 381 1001190 3414 62484037
Hypomagnesaemia 383.93 13.57 16 1001555 28721 62458730
Pneumonia aspiration 382.84 13.57 47 1001524 34493 62452958
Acute respiratory failure 367.72 13.57 53 1001518 34432 62453019
Blood alkaline phosphatase increased 366.15 13.57 111 1001460 42856 62444595
Osteonecrosis of jaw 363.06 13.57 59 1001512 35064 62452387
Alanine aminotransferase increased 359.19 13.57 681 1000890 103089 62384362
Melaena 357.84 13.57 33 1001538 30332 62457119
Heart rate decreased 356.48 13.57 136 1001435 45424 62442027
Respiratory distress 355.53 13.57 55 1001516 33896 62453555
Hepatic function abnormal 354.84 13.57 76 1001495 37066 62450385
Dysphagia 353.99 13.57 530 1001041 88055 62399396
Rectal haemorrhage 353.74 13.57 165 1001406 48865 62438586
Herpes zoster 353.09 13.57 2370 999201 80092 62407359
Renal impairment 351.74 13.57 530 1001041 87825 62399626
Disorientation 350.83 13.57 94 1001477 39358 62448093
Blood glucose increased 350.57 13.57 485 1001086 83271 62404180
Gastrooesophageal reflux disease 350.39 13.57 606 1000965 95033 62392418
Unevaluable event 350.18 13.57 1673 999898 49713 62437738
Hypervolaemia 348.29 13.57 26 1001545 28387 62459064
Pharyngitis streptococcal 346.33 13.57 612 1000959 10060 62477391
Plasma cell myeloma 346.03 13.57 72 1001499 35833 62451618
Lymphocyte count decreased 345.80 13.57 37 1001534 30220 62457231
Drug withdrawal syndrome 344.73 13.57 21 1001550 27173 62460278
Intentional self-injury 344.19 13.57 14 1001557 25673 62461778
Red blood cell sedimentation rate increased 342.19 13.57 1489 1000082 42493 62444958
Chronic kidney disease 338.15 13.57 146 1001425 45252 62442199
Pemphigus 334.21 13.57 4395 997176 179331 62308120
Aspartate aminotransferase increased 332.58 13.57 570 1001001 89707 62397744
Blood creatine phosphokinase increased 331.00 13.57 44 1001527 30386 62457065
Pulmonary hypertension 325.33 13.57 91 1001480 37032 62450419
Injection site hypersensitivity 323.68 13.57 267 1001304 1830 62485621
Drug level increased 320.31 13.57 8 1001563 22728 62464723
Chest discomfort 319.13 13.57 796 1000775 109173 62378278
Cholestasis 319.11 13.57 43 1001528 29391 62458060
COVID-19 317.19 13.57 833 1000738 112270 62375181
Toxic epidermal necrolysis 316.86 13.57 21 1001550 25313 62462138
Hepatic failure 315.09 13.57 86 1001485 35570 62451881
Loss of personal independence in daily activities 314.36 13.57 2616 998955 94674 62392777
Ear infection 311.39 13.57 1312 1000259 36901 62450550
Acute myocardial infarction 310.44 13.57 64 1001507 32060 62455391
Impaired healing 310.17 13.57 2717 998854 99825 62387626
Grip strength decreased 309.04 13.57 912 1000659 21375 62466076
Gamma-glutamyltransferase increased 308.50 13.57 78 1001493 33953 62453498
Angioedema 307.05 13.57 188 1001383 47777 62439674
Haematemesis 303.57 13.57 56 1001515 30356 62457095
Balance disorder 301.94 13.57 543 1001028 83879 62403572
Bone marrow failure 300.97 13.57 50 1001521 29240 62458211
Jaundice 300.42 13.57 50 1001521 29201 62458250
Blood pressure fluctuation 300.05 13.57 179 1001392 46138 62441313
Psychotic disorder 297.56 13.57 30 1001541 25682 62461769
Hepatocellular injury 296.85 13.57 40 1001531 27341 62460110
Loss of consciousness 296.66 13.57 917 1000654 117204 62370247
Coronary artery disease 295.84 13.57 73 1001498 32304 62455147
Pulmonary arterial hypertension 293.71 13.57 15 1001556 22562 62464889
Myalgia 293.65 13.57 1250 1000321 145279 62342172
Blood calcium decreased 293.14 13.57 36 1001535 26415 62461036
Generalised tonic-clonic seizure 288.41 13.57 54 1001517 28962 62458489
Urinary retention 287.43 13.57 63 1001508 30238 62457213
Oedema 286.88 13.57 702 1000869 96920 62390531
Fluid retention 285.15 13.57 312 1001259 59374 62428077
Hypertension 285.09 13.57 2922 998649 276381 62211070
Altered state of consciousness 282.91 13.57 33 1001538 25197 62462254
Pneumonia 278.01 13.57 5305 996266 451462 62035989
Device dislocation 277.61 13.57 38 1001533 25667 62461784
Arrhythmia 275.69 13.57 128 1001443 38012 62449439
Product quality issue 270.87 13.57 113 1001458 35752 62451699
Haemorrhage 268.99 13.57 340 1001231 60682 62426769
Lethargy 268.42 13.57 292 1001279 55715 62431736
Ventricular tachycardia 267.32 13.57 11 1001560 19968 62467483
Agranulocytosis 267.12 13.57 39 1001532 25095 62462356
Abdominal discomfort 266.13 13.57 6785 994786 314100 62173351
Aphasia 265.79 13.57 94 1001477 32906 62454545
Pyrexia 265.66 13.57 5533 996038 464945 62022506
Psoriatic arthropathy 263.93 13.57 2400 999171 89120 62398331
Upper respiratory tract infection 262.29 13.57 2201 999370 79846 62407605
Stevens-Johnson syndrome 262.20 13.57 40 1001531 24910 62462541
Sinus tachycardia 261.79 13.57 36 1001535 24232 62463219
Depression 261.26 13.57 1919 999652 194573 62292878
Full blood count decreased 259.59 13.57 48 1001523 25976 62461475
Delirium 258.68 13.57 249 1001322 50292 62437159
Aggression 257.93 13.57 33 1001538 23465 62463986
Withdrawal syndrome 257.90 13.57 14 1001557 19983 62467468
Contusion 257.81 13.57 3553 998018 146491 62340960
Accidental overdose 257.64 13.57 32 1001539 23277 62464174
Asthma 257.55 13.57 1085 1000486 126476 62360975
Shock 257.42 13.57 33 1001538 23430 62464021
Septic shock 256.26 13.57 409 1001162 66220 62421231
Pancreatitis acute 254.63 13.57 58 1001513 27108 62460343
General physical health deterioration 250.34 13.57 2004 999567 199398 62288053
Blood urea increased 249.90 13.57 55 1001516 26324 62461127
Blood potassium decreased 249.72 13.57 179 1001392 41847 62445604
Foot operation 249.42 13.57 426 1001145 6805 62480646
No adverse event 249.13 13.57 174 1001397 41231 62446220
Circulatory collapse 247.73 13.57 28 1001543 21910 62465541
Oedema peripheral 247.09 13.57 1861 999710 187650 62299801
Haematoma 246.86 13.57 120 1001451 34700 62452751
Gait disturbance 246.25 13.57 4160 997411 179018 62308433
Joint destruction 246.21 13.57 391 1001180 5861 62481590
Ejection fraction decreased 246.01 13.57 31 1001540 22301 62465150
Diabetic ketoacidosis 245.10 13.57 21 1001550 20484 62466967
Colitis 244.99 13.57 242 1001329 48286 62439165
Cerebral haemorrhage 244.99 13.57 89 1001482 30640 62456811
Hypocalcaemia 244.24 13.57 97 1001474 31616 62455835
Myocardial infarction 244.13 13.57 785 1000786 99108 62388343
Leukocytosis 243.83 13.57 55 1001516 25880 62461571
Neurotoxicity 243.15 13.57 5 1001566 16985 62470466
Acute hepatic failure 242.20 13.57 11 1001560 18316 62469135
Electrolyte imbalance 241.51 13.57 20 1001551 20056 62467395
Glossodynia 241.43 13.57 4065 997506 174811 62312640
Blood lactate dehydrogenase increased 240.79 13.57 38 1001533 23078 62464373
Upper gastrointestinal haemorrhage 240.66 13.57 14 1001557 18838 62468613
Therapeutic product effect delayed 240.00 13.57 239 1001332 2152 62485299
Myelosuppression 237.98 13.57 43 1001528 23660 62463791
Infusion site pain 237.40 13.57 6 1001565 16863 62470588
Leukopenia 237.28 13.57 543 1001028 76747 62410704
Drug ineffective for unapproved indication 236.05 13.57 121 1001450 33942 62453509
Eosinophilia 235.70 13.57 38 1001533 22718 62464733
Abdominal distension 232.99 13.57 651 1000920 85964 62401487
Injection site nodule 232.91 13.57 295 1001276 3540 62483911
Epistaxis 232.22 13.57 500 1001071 72225 62415226
Sinus headache 230.56 13.57 358 1001213 5258 62482193
Hip arthroplasty 228.87 13.57 1410 1000161 46236 62441215
Neck pain 228.22 13.57 1872 999699 67446 62420005
Rash 228.20 13.57 10922 990649 549949 61937502
Therapy cessation 227.71 13.57 1019 1000552 29438 62458013
Posterior reversible encephalopathy syndrome 227.31 13.57 11 1001560 17334 62470117
Small intestinal obstruction 227.00 13.57 16 1001555 18321 62469130
Rheumatoid factor positive 226.61 13.57 2180 999391 82226 62405225
Increased tendency to bruise 224.19 13.57 507 1001064 10045 62477406
Obstructive airways disorder 222.59 13.57 31 1001540 20668 62466783
Blood pressure diastolic decreased 221.98 13.57 44 1001527 22662 62464789
Hepatic enzyme increased 221.07 13.57 4449 997122 197879 62289572
Neutropenic sepsis 220.10 13.57 9 1001562 16429 62471022
Adverse drug reaction 220.05 13.57 2071 999500 77643 62409808
Inappropriate antidiuretic hormone secretion 219.51 13.57 5 1001566 15457 62471994
Hallucination, visual 219.51 13.57 24 1001547 19274 62468177
Dyskinesia 218.33 13.57 116 1001455 31886 62455565
Tachypnoea 217.40 13.57 14 1001557 17288 62470163
Status epilepticus 215.97 13.57 5 1001566 15228 62472223
Haematocrit decreased 215.45 13.57 182 1001389 39158 62448293
Cardiogenic shock 215.34 13.57 18 1001553 17914 62469537
Myoclonus 214.81 13.57 8 1001563 15860 62471591
Thrombosis 214.49 13.57 436 1001135 64319 62423132
Emotional distress 213.36 13.57 124 1001447 32425 62455026
Epilepsy 213.05 13.57 80 1001491 26985 62460466
Right ventricular failure 212.76 13.57 15 1001556 17173 62470278
Rheumatoid nodule 212.64 13.57 675 1000896 16480 62470971
Abnormal behaviour 210.56 13.57 41 1001530 21385 62466066
Cerebral infarction 210.42 13.57 58 1001513 23835 62463616
Rubber sensitivity 210.34 13.57 220 1001351 2111 62485340
Hemiparesis 209.81 13.57 54 1001517 23228 62464223
Restlessness 209.56 13.57 101 1001470 29352 62458099
Wheezing 209.49 13.57 787 1000784 94808 62392643
Tuberculin test positive 206.80 13.57 266 1001305 3245 62484206
Premature delivery 206.23 13.57 110 1001461 30171 62457280
Joint range of motion decreased 206.05 13.57 1035 1000536 31393 62456058
Bone erosion 205.95 13.57 682 1000889 17035 62470416
Urinary incontinence 205.57 13.57 125 1001446 31889 62455562
Chondrolysis 203.76 13.57 90 1001481 137 62487314
Shoulder arthroplasty 203.21 13.57 282 1001289 3720 62483731
Rhinorrhoea 202.10 13.57 1745 999826 63832 62423619
Cholelithiasis 201.77 13.57 237 1001334 43688 62443763
Haematuria 201.41 13.57 104 1001467 29053 62458398
Respiratory depression 200.55 13.57 3 1001568 13712 62473739
Disturbance in attention 200.30 13.57 184 1001387 38005 62449446
Adverse event 200.04 13.57 1782 999789 65777 62421674
Pericardial effusion 199.18 13.57 113 1001458 29945 62457506
Coagulopathy 198.37 13.57 41 1001530 20503 62466948
Clostridium difficile colitis 196.65 13.57 42 1001529 20527 62466924
Full blood count abnormal 196.56 13.57 129 1001442 31588 62455863
Rash maculo-papular 195.95 13.57 131 1001440 31765 62455686
Metastases to bone 194.77 13.57 46 1001525 20973 62466478
Pancreatitis 194.48 13.57 295 1001276 48760 62438691
Knee operation 191.48 13.57 342 1001229 5671 62481780
Gastritis 188.32 13.57 186 1001385 37117 62450334
Blood pressure diastolic abnormal 188.10 13.57 10 1001561 14532 62472919
Labelled drug-drug interaction medication error 187.68 13.57 5 1001566 13394 62474057
Sinus congestion 186.57 13.57 670 1000901 17453 62469998
Frequent bowel movements 186.39 13.57 65 1001506 22957 62464494
Hypothermia 183.32 13.57 7 1001564 13574 62473877
Antibiotic therapy 183.14 13.57 146 1001425 947 62486504
Cyanosis 182.96 13.57 25 1001546 16910 62470541
Injection site injury 182.77 13.57 120 1001451 546 62486905
Ill-defined disorder 182.19 13.57 2033 999538 79722 62407729
Sinus bradycardia 182.16 13.57 12 1001559 14539 62472912
Poisoning 181.78 13.57 8 1001563 13692 62473759
Face oedema 180.00 13.57 48 1001523 20164 62467287
Demyelination 177.57 13.57 359 1001212 6561 62480890
Blood iron abnormal 177.50 13.57 260 1001311 3616 62483835
Blood sodium decreased 177.44 13.57 80 1001491 24172 62463279
Product prescribing error 176.84 13.57 97 1001474 26192 62461259
Sleep disorder due to general medical condition, insomnia type 175.01 13.57 1416 1000155 50801 62436650
Presyncope 174.93 13.57 111 1001460 27674 62459777
Neuroleptic malignant syndrome 174.76 13.57 3 1001568 12053 62475398
Acute respiratory distress syndrome 174.76 13.57 76 1001495 23458 62463993
Transient ischaemic attack 174.16 13.57 203 1001368 37550 62449901
Tubulointerstitial nephritis 174.00 13.57 49 1001522 19854 62467597
Ischaemic stroke 173.05 13.57 36 1001535 17921 62469530
Extrapyramidal disorder 172.25 13.57 9 1001562 13275 62474176
Dystonia 171.23 13.57 12 1001559 13807 62473644
Gastroenteritis 169.09 13.57 105 1001466 26485 62460966
Osteoarthritis 168.29 13.57 2269 999302 93074 62394377
Intestinal obstruction 167.92 13.57 144 1001427 30755 62456696
Anuria 167.62 13.57 7 1001564 12544 62474907
Bacteraemia 166.72 13.57 35 1001536 17313 62470138
Lymphopenia 166.12 13.57 42 1001529 18285 62469166
Speech disorder 165.27 13.57 240 1001331 40389 62447062
Subdural haematoma 165.07 13.57 17 1001554 14311 62473140
Infusion site erythema 164.94 13.57 4 1001567 11675 62475776
Metastases to liver 163.75 13.57 84 1001487 23555 62463896
Premature baby 163.70 13.57 61 1001510 20674 62466777
Angina pectoris 163.67 13.57 140 1001431 29938 62457513
Transfusion 163.14 13.57 23 1001548 15194 62472257
Medication error 161.53 13.57 366 1001205 51918 62435533
Osteonecrosis 161.42 13.57 93 1001478 24437 62463014
Dysgeusia 158.55 13.57 310 1001261 46400 62441051
Anhedonia 157.97 13.57 3 1001568 10971 62476480
Complication associated with device 157.62 13.57 37 1001534 16941 62470510
Haemorrhage intracranial 157.01 13.57 15 1001556 13404 62474047
Cytomegalovirus infection 156.63 13.57 67 1001504 20885 62466566
Hypothyroidism 156.21 13.57 270 1001301 42362 62445089
Corrective lens user 155.84 13.57 78 1001493 182 62487269
Brain oedema 155.64 13.57 20 1001551 14175 62473276
Breast cancer 155.14 13.57 1299 1000272 47084 62440367
Arthropod bite 154.88 13.57 370 1001201 7608 62479843
Vision blurred 154.43 13.57 835 1000736 91089 62396362
Renal tubular necrosis 154.17 13.57 8 1001563 11870 62475581
Flatulence 153.29 13.57 193 1001378 34509 62452942
Respiratory rate increased 152.65 13.57 18 1001553 13630 62473821
Mycobacterium tuberculosis complex test positive 152.58 13.57 183 1001388 2068 62485383
Acidosis 150.91 13.57 6 1001565 11227 62476224
Chronic obstructive pulmonary disease 150.77 13.57 496 1001075 62190 62425261
Dyspepsia 150.61 13.57 968 1000603 101228 62386223
Tricuspid valve incompetence 150.12 13.57 25 1001546 14596 62472855
Mania 149.65 13.57 12 1001559 12355 62475096
Ataxia 149.48 13.57 29 1001542 15166 62472285
Acne 149.08 13.57 745 1000826 22548 62464903
Haemoptysis 148.77 13.57 140 1001431 28586 62458865
Sleep apnoea syndrome 148.52 13.57 144 1001427 28989 62458462
Intentional product misuse 148.32 13.57 1542 1000029 59375 62428076
Hepatic cytolysis 148.24 13.57 31 1001540 15376 62472075
COVID-19 pneumonia 146.55 13.57 24 1001547 14185 62473266
Decreased immune responsiveness 146.23 13.57 271 1001300 4630 62482821
Infusion site extravasation 145.62 13.57 4 1001567 10422 62477029
Cardiomegaly 145.61 13.57 48 1001523 17566 62469885
Treatment noncompliance 145.52 13.57 227 1001344 37098 62450353
Joint arthroplasty 144.99 13.57 197 1001374 2544 62484907
Wound 144.84 13.57 3485 998086 159778 62327673
Left ventricular dysfunction 144.04 13.57 12 1001559 11976 62475475
Malaise 142.89 13.57 7973 993598 407981 62079470
Joint warmth 142.59 13.57 145 1001426 1342 62486109
Hyperhidrosis 142.32 13.57 1055 1000516 106781 62380670
Parkinsonism 142.22 13.57 5 1001566 10434 62477017
Blood pressure systolic abnormal 141.72 13.57 21 1001550 13365 62474086
Joint effusion 141.51 13.57 589 1000982 16471 62470980
Shock haemorrhagic 141.26 13.57 3 1001568 9892 62477559
Malnutrition 140.72 13.57 34 1001537 15264 62472187
Abdominal pain lower 139.13 13.57 120 1001451 25558 62461893
Supraventricular tachycardia 138.79 13.57 28 1001543 14243 62473208
Metastases to central nervous system 137.73 13.57 21 1001550 13084 62474367
Localised infection 137.59 13.57 882 1000689 29328 62458123
Troponin increased 137.36 13.57 5 1001566 10116 62477335
Pallor 137.13 13.57 168 1001403 30400 62457051
Ear pain 136.91 13.57 1008 1000563 35110 62452341
Injection site papule 135.89 13.57 108 1001463 697 62486754
Tooth infection 135.03 13.57 601 1000970 17319 62470132
Disability 135.01 13.57 611 1000960 17736 62469715
Anti-cyclic citrullinated peptide antibody positive 134.75 13.57 2579 998992 113633 62373818
Taste disorder 134.55 13.57 26 1001545 13636 62473815
Disseminated intravascular coagulation 134.52 13.57 66 1001505 18985 62468466
Joint injury 134.45 13.57 863 1000708 28709 62458742
Acute generalised exanthematous pustulosis 133.66 13.57 11 1001560 11088 62476363
Mydriasis 133.15 13.57 16 1001555 11940 62475511
Diabetes mellitus inadequate control 132.67 13.57 37 1001534 15089 62472362
Extra dose administered 132.56 13.57 303 1001268 6047 62481404
Blood magnesium decreased 132.37 13.57 24 1001547 13174 62474277
Mitral valve incompetence 132.23 13.57 72 1001499 19522 62467929
Infusion site swelling 132.00 13.57 5 1001566 9765 62477686
Ventricular fibrillation 131.87 13.57 16 1001555 11851 62475600
Transaminases increased 131.84 13.57 181 1001390 31186 62456265
Device failure 131.26 13.57 292 1001279 5719 62481732
Ileus 129.19 13.57 36 1001535 14689 62472762
Nightmare 128.85 13.57 71 1001500 19123 62468328
Cholecystitis chronic 128.37 13.57 9 1001562 10352 62477099
Acute myeloid leukaemia 127.91 13.57 55 1001516 17092 62470359
Joint noise 127.48 13.57 240 1001331 4152 62483299
Heart rate irregular 127.41 13.57 100 1001471 22321 62465130
Hallucination, auditory 127.16 13.57 24 1001547 12800 62474651
Spinal operation 125.86 13.57 350 1001221 7921 62479530
Body temperature decreased 125.42 13.57 83 1001488 20236 62467215
Red blood cell count decreased 125.17 13.57 285 1001286 40360 62447091
Dermatitis atopic 124.80 13.57 7 1001564 9717 62477734
Muscle rigidity 124.18 13.57 17 1001554 11483 62475968
Hypoalbuminaemia 123.88 13.57 19 1001552 11786 62475665
Joint lock 123.62 13.57 167 1001404 2144 62485307
Device malfunction 123.51 13.57 584 1000987 17273 62470178
Cardiac disorder 122.95 13.57 401 1001170 50415 62437036
Joint fluid drainage 122.20 13.57 60 1001511 132 62487319
Myelodysplastic syndrome 121.43 13.57 56 1001515 16698 62470753
Limb operation 120.40 13.57 223 1001348 3808 62483643
Sneezing 120.37 13.57 588 1000983 17630 62469821
Tardive dyskinesia 119.73 13.57 3 1001568 8499 62478952
Myocardial ischaemia 119.42 13.57 28 1001543 12831 62474620
Cytopenia 118.75 13.57 20 1001551 11581 62475870
Headache 118.66 13.57 11560 990011 621681 61865770
Clostridium difficile infection 118.54 13.57 180 1001391 29742 62457709
Oliguria 118.53 13.57 6 1001565 9095 62478356
Vertigo 117.97 13.57 514 1001057 59373 62428078
Lower respiratory tract infection 117.86 13.57 2826 998745 129481 62357970
Toxic skin eruption 117.81 13.57 29 1001542 12856 62474595
Urine output decreased 117.73 13.57 19 1001552 11351 62476100
Paraesthesia oral 117.06 13.57 80 1001491 19176 62468275
Haemodynamic instability 116.77 13.57 7 1001564 9183 62478268
Circumstance or information capable of leading to medication error 116.73 13.57 215 1001356 3655 62483796
Muscle spasms 116.30 13.57 1747 999824 154403 62333048
Delusion 115.99 13.57 24 1001547 11993 62475458
Anal incontinence 115.79 13.57 35 1001536 13541 62473910
Paranoia 115.50 13.57 22 1001549 11657 62475794
Rales 115.27 13.57 29 1001542 12668 62474783
Irritability 114.96 13.57 202 1001369 31492 62455959
Aspiration 114.93 13.57 17 1001554 10834 62476617
Device related infection 114.25 13.57 120 1001451 23272 62464179
Haematotoxicity 113.73 13.57 9 1001562 9367 62478084
Intentional product use issue 113.63 13.57 1380 1000191 126512 62360939
Pustular psoriasis 112.81 13.57 235 1001336 4391 62483060
Macular degeneration 112.51 13.57 131 1001440 24245 62463206
Transplant rejection 112.21 13.57 400 1001171 10380 62477071
Renal injury 111.91 13.57 10 1001561 9429 62478022
Acute coronary syndrome 111.67 13.57 14 1001557 10112 62477339
Fibromyalgia 111.09 13.57 1835 999736 78585 62408866
Prothrombin time prolonged 111.08 13.57 11 1001560 9553 62477898
Urinary tract infection 111.05 13.57 3252 998319 261432 62226019
Blood loss anaemia 110.99 13.57 8 1001563 8993 62478458
Mental disorder 110.52 13.57 148 1001423 25771 62461680
Tinnitus 110.38 13.57 249 1001322 35379 62452072
Lower gastrointestinal haemorrhage 110.30 13.57 3 1001568 7887 62479564
Deformity 110.25 13.57 420 1001151 11264 62476187
Wrist surgery 109.86 13.57 99 1001472 776 62486675
Rash pruritic 109.59 13.57 1433 1000138 58366 62429085
Poor venous access 109.38 13.57 48 1001523 14737 62472714
Glomerular filtration rate decreased 108.73 13.57 38 1001533 13403 62474048
Thrombotic microangiopathy 108.56 13.57 18 1001553 10543 62476908
Lipase increased 108.42 13.57 14 1001557 9886 62477565
Pharyngitis 107.58 13.57 613 1000958 19530 62467921
Schizophrenia 106.79 13.57 15 1001556 9937 62477514
Atelectasis 106.29 13.57 109 1001462 21374 62466077
Subarachnoid haemorrhage 106.25 13.57 46 1001525 14237 62473214
Blood albumin decreased 106.02 13.57 50 1001521 14716 62472735
Hypernatraemia 105.98 13.57 3 1001568 7606 62479845
Cardiomyopathy 105.64 13.57 74 1001497 17510 62469941
Complication of device insertion 105.28 13.57 3 1001568 7561 62479890
Weight increased 105.24 13.57 3221 998350 257571 62229880
Hyperthermia 105.13 13.57 11 1001560 9145 62478306
Muscle injury 104.75 13.57 1529 1000042 63816 62423635
Device difficult to use 103.95 13.57 439 1001132 12357 62475094
Eye disorder 103.73 13.57 663 1000908 22022 62465429
Hypovolaemia 103.67 13.57 21 1001550 10652 62476799
Walking aid user 103.41 13.57 388 1001183 10329 62477122
Myocarditis 103.07 13.57 19 1001552 10306 62477145
Cardiac failure acute 103.02 13.57 14 1001557 9509 62477942
Injection site laceration 102.84 13.57 45 1001526 66 62487385
Folliculitis 102.55 13.57 1619 999952 68698 62418753
Nephropathy toxic 102.39 13.57 14 1001557 9465 62477986
Pneumonitis 102.08 13.57 255 1001316 34967 62452484
Cough 101.67 13.57 5618 995953 287125 62200326
Injection site paraesthesia 101.67 13.57 79 1001492 491 62486960
Hydronephrosis 101.46 13.57 22 1001549 10640 62476811
Ovarian cyst 101.34 13.57 509 1001062 15436 62472015
Lip swelling 101.28 13.57 211 1001360 30852 62456599
Atrioventricular block first degree 100.81 13.57 3 1001568 7270 62480181
Chondropathy 100.60 13.57 151 1001420 2149 62485302
Hypophagia 100.52 13.57 214 1001357 31045 62456406
Haemolytic anaemia 100.29 13.57 19 1001552 10106 62477345
Impaired work ability 100.12 13.57 542 1001029 16933 62470518
Vaginal haemorrhage 99.86 13.57 175 1001396 27312 62460139
Haemodialysis 99.57 13.57 12 1001559 8935 62478516
Klebsiella infection 99.10 13.57 10 1001561 8556 62478895
Iritis 99.07 13.57 179 1001392 2996 62484455
Device use error 98.98 13.57 255 1001316 5506 62481945
Off label use 98.85 13.57 9230 992341 665232 61822219
Second primary malignancy 98.27 13.57 7 1001564 7946 62479505
Drug dependence 98.23 13.57 146 1001425 24337 62463114
Ventricular extrasystoles 98.11 13.57 31 1001540 11656 62475795
Tumour lysis syndrome 97.77 13.57 13 1001558 8977 62478474
Swollen tongue 97.73 13.57 256 1001315 34544 62452907
Incorrect disposal of product 97.66 13.57 83 1001488 596 62486855
Product complaint 97.29 13.57 40 1001531 12769 62474682
Hospitalisation 97.29 13.57 865 1000706 84216 62403235
Oesophagitis 97.19 13.57 58 1001513 14950 62472501
Atrioventricular block complete 97.13 13.57 9 1001562 8242 62479209
Myopathy 97.00 13.57 28 1001543 11163 62476288
Drug-induced liver injury 96.20 13.57 319 1001252 39903 62447548
Uterine perforation 96.05 13.57 3 1001568 6960 62480491
Colitis ulcerative 95.80 13.57 165 1001406 25926 62461525
Viral upper respiratory tract infection 95.80 13.57 304 1001267 7420 62480031
Fine motor skill dysfunction 94.99 13.57 225 1001346 4600 62482851
Apathy 94.96 13.57 13 1001558 8781 62478670
Drug level decreased 94.95 13.57 8 1001563 7911 62479540
Haemorrhoids 94.93 13.57 126 1001445 22024 62465427
Limb deformity 94.91 13.57 201 1001370 3801 62483650
Jaundice cholestatic 94.85 13.57 5 1001566 7319 62480132
Aplastic anaemia 94.69 13.57 18 1001553 9551 62477900
Incorrect product administration duration 94.51 13.57 32 1001539 11514 62475937
Discomfort 94.36 13.57 3376 998195 163998 62323453
Enterococcal infection 93.90 13.57 8 1001563 7840 62479611
Bronchospasm 93.32 13.57 81 1001490 17199 62470252
Peritonitis 93.14 13.57 80 1001491 17074 62470377
Failure to thrive 92.94 13.57 5 1001566 7193 62480258
Deafness transitory 92.90 13.57 134 1001437 1836 62485615
Chromaturia 91.94 13.57 77 1001494 16640 62470811
Blood potassium increased 91.60 13.57 92 1001479 18217 62469234
Therapeutic response delayed 91.09 13.57 79 1001492 585 62486866
Normal newborn 90.85 13.57 12 1001559 8329 62479122
Liver function test increased 90.27 13.57 852 1000719 31959 62455492
Rhinitis allergic 90.08 13.57 36 1001535 11691 62475760
Faecaloma 90.00 13.57 10 1001561 7931 62479520
Anaphylactic shock 89.97 13.57 146 1001425 23487 62463964
Hospice care 89.87 13.57 10 1001561 7922 62479529
Drug resistance 89.84 13.57 139 1001432 22794 62464657
Furuncle 89.41 13.57 267 1001304 6299 62481152
Bronchitis chronic 88.98 13.57 206 1001365 4147 62483304
Stress cardiomyopathy 88.91 13.57 20 1001551 9430 62478021
Respiratory acidosis 88.83 13.57 4 1001567 6711 62480740
Blood lactic acid increased 88.24 13.57 6 1001565 7080 62480371
Proteinuria 88.24 13.57 103 1001468 19042 62468409
Irritable bowel syndrome 88.15 13.57 1807 999764 80605 62406846
Nasal congestion 88.03 13.57 1491 1000080 64169 62423282
Hypertransaminasaemia 87.22 13.57 4 1001567 6605 62480846
Faeces discoloured 87.02 13.57 98 1001473 18411 62469040
Polyneuropathy 86.84 13.57 62 1001509 14527 62472924
Psychomotor hyperactivity 86.50 13.57 30 1001541 10633 62476818
Insomnia 86.44 13.57 2660 998911 212592 62274859
Vascular device infection 86.01 13.57 8 1001563 7304 62480147
Acute pulmonary oedema 85.90 13.57 13 1001558 8145 62479306
End stage renal disease 85.34 13.57 5 1001566 6688 62480763
Chills 85.24 13.57 1266 1000305 112112 62375339
Urosepsis 85.01 13.57 100 1001471 18424 62469027
Muscular weakness 84.64 13.57 1388 1000183 120965 62366486
Spinal fusion surgery 84.49 13.57 237 1001334 5391 62482060
White blood cell count increased 84.38 13.57 436 1001135 48125 62439326
Apnoea 83.97 13.57 13 1001558 8009 62479442
Bone pain 83.86 13.57 511 1001060 54130 62433321
Arthrodesis 83.72 13.57 155 1001416 2646 62484805
Eosinophil count increased 83.21 13.57 34 1001537 10894 62476557
Cholecystitis 83.14 13.57 72 1001499 15305 62472146
Secretion discharge 83.13 13.57 398 1001173 11833 62475618
Product substitution issue 82.78 13.57 78 1001493 15918 62471533
Hepatomegaly 82.72 13.57 42 1001529 11847 62475604
Hip surgery 82.15 13.57 170 1001401 3161 62484290
Colitis ischaemic 82.05 13.57 33 1001538 10675 62476776
Shoulder operation 81.93 13.57 140 1001431 2237 62485214
Infusion site pruritus 81.84 13.57 3 1001568 6032 62481419
Metastases to lung 81.55 13.57 50 1001521 12700 62474751
Sickle cell anaemia with crisis 81.35 13.57 3 1001568 6000 62481451
Fistula 81.33 13.57 31 1001540 10362 62477089
Limb discomfort 80.94 13.57 770 1000801 28946 62458505
Haemolysis 80.70 13.57 7 1001564 6761 62480690
Hepatitis acute 80.57 13.57 22 1001549 9098 62478353
Hypertensive crisis 79.74 13.57 74 1001497 15212 62472239
Skin haemorrhage 79.45 13.57 343 1001228 9751 62477700
Abortion induced 79.40 13.57 31 1001540 10211 62477240
Renal disorder 79.21 13.57 261 1001310 32713 62454738
Diplopia 79.21 13.57 159 1001412 23569 62463882
Exostosis 79.19 13.57 518 1001053 17344 62470107
Sinus disorder 79.12 13.57 660 1000911 23893 62463558
Hypotonia 79.07 13.57 24 1001547 9261 62478190
Metabolic encephalopathy 78.39 13.57 3 1001568 5806 62481645
Ageusia 78.29 13.57 61 1001510 13667 62473784
Toothache 78.07 13.57 545 1001026 18654 62468797
Hemiplegia 77.78 13.57 25 1001546 9298 62478153
Angina unstable 77.78 13.57 10 1001561 7085 62480366
Hyperthyroidism 77.77 13.57 70 1001501 14603 62472848
Rheumatoid factor increased 77.49 13.57 119 1001452 1730 62485721
Activated partial thromboplastin time prolonged 77.32 13.57 9 1001562 6884 62480567
Dialysis 76.90 13.57 34 1001537 10393 62477058
Erythema multiforme 76.84 13.57 32 1001539 10137 62477314
Salivary hypersecretion 76.75 13.57 14 1001557 7652 62479799
Atrial flutter 76.72 13.57 29 1001542 9743 62477708
Hepatic necrosis 76.53 13.57 3 1001568 5684 62481767
Uveitis 76.48 13.57 396 1001175 12157 62475294
Blood pressure diastolic increased 76.45 13.57 31 1001540 9979 62477472
Tuberculosis 76.34 13.57 365 1001206 10846 62476605
Stress 76.25 13.57 1486 1000085 65681 62421770
Increased upper airway secretion 75.31 13.57 174 1001397 3498 62483953
Incontinence 75.26 13.57 45 1001526 11587 62475864
Neutrophil count increased 75.01 13.57 90 1001481 16437 62471014
Immune system disorder 74.99 13.57 331 1001240 9503 62477948
Polyuria 74.72 13.57 21 1001550 8521 62478930
Macule 74.64 13.57 123 1001448 1905 62485546
Hiatus hernia 73.55 13.57 143 1001428 21451 62466000
Pneumothorax 73.33 13.57 89 1001482 16172 62471279
C-reactive protein increased 73.17 13.57 1985 999586 92722 62394729
Dysuria 73.07 13.57 279 1001292 33459 62453992
Rash erythematous 73.05 13.57 1007 1000564 41503 62445948
Dementia 72.59 13.57 115 1001456 18679 62468772
Sudden death 72.57 13.57 37 1001534 10412 62477039
Hyperlipidaemia 72.56 13.57 123 1001448 19448 62468003
Skin ulcer 72.48 13.57 1016 1000555 42029 62445422
Pericarditis 72.17 13.57 2646 998925 128933 62358518
Personality disorder 72.13 13.57 5 1001566 5806 62481645
Genital haemorrhage 72.11 13.57 14 1001557 7318 62480133
Asphyxia 72.07 13.57 7 1001564 6174 62481277
Lung infiltration 71.98 13.57 73 1001498 14390 62473061
Amylase increased 71.89 13.57 8 1001563 6337 62481114
Device breakage 71.44 13.57 47 1001524 11495 62475956
Elbow deformity 71.37 13.57 103 1001468 1412 62486039
Enterocolitis 71.24 13.57 18 1001553 7840 62479611
Affect lability 70.95 13.57 44 1001527 11107 62476344
Aspergillus infection 70.60 13.57 20 1001551 8073 62479378
Hypovolaemic shock 70.38 13.57 8 1001563 6233 62481218
Ankle operation 70.36 13.57 94 1001477 1193 62486258
Blister 70.35 13.57 2607 998964 127207 62360244
Injury 69.83 13.57 778 1000793 72469 62414982
Anaphylactic reaction 69.56 13.57 686 1000885 65414 62422037
Enteritis 69.52 13.57 22 1001549 8264 62479187
Female genital tract fistula 69.14 13.57 17 1001554 7542 62479909
Bradykinesia 68.93 13.57 3 1001568 5185 62482266
Atypical femur fracture 68.54 13.57 4 1001567 5368 62482083
Head injury 68.50 13.57 213 1001358 27183 62460268
Blood triglycerides increased 68.09 13.57 58 1001513 12430 62475021
Arteriosclerosis 67.91 13.57 37 1001534 10029 62477422
Decubitus ulcer 67.64 13.57 41 1001530 10479 62476972
Gastrointestinal disorder 67.63 13.57 2621 998950 128618 62358833
Hereditary angioedema 67.26 13.57 18 1001553 7544 62479907
Low birth weight baby 67.25 13.57 15 1001556 7114 62480337
Ankle deformity 67.24 13.57 58 1001513 426 62487025
Cytomegalovirus viraemia 66.93 13.57 6 1001565 5643 62481808
Concomitant disease aggravated 66.75 13.57 30 1001541 9082 62478369
Atrial septal defect 66.67 13.57 14 1001557 6924 62480527
Proctitis 66.62 13.57 5 1001566 5436 62482015
Atrioventricular block 66.52 13.57 19 1001552 7628 62479823
Retching 66.20 13.57 80 1001491 14565 62472886
Scratch 66.12 13.57 241 1001330 6324 62481127
Panic attack 66.02 13.57 160 1001411 22171 62465280
Depressed mood 65.87 13.57 368 1001203 39823 62447628
Forced expiratory volume decreased 65.59 13.57 3 1001568 4965 62482486
Arteriosclerosis coronary artery 65.48 13.57 25 1001546 8348 62479103
Foetal growth restriction 65.27 13.57 19 1001552 7534 62479917
Bradyphrenia 65.22 13.57 15 1001556 6965 62480486
Catheter site infection 64.77 13.57 3 1001568 4911 62482540
Granulocytopenia 64.65 13.57 7 1001564 5665 62481786
Partial seizures 64.61 13.57 8 1001563 5834 62481617
Diastolic dysfunction 64.40 13.57 12 1001559 6459 62480992
Rib fracture 64.39 13.57 165 1001406 22432 62465019
Product dose omission in error 64.24 13.57 20 1001551 7592 62479859
Cardiac murmur 64.20 13.57 81 1001490 14471 62472980
Iron deficiency anaemia 63.96 13.57 137 1001434 19832 62467619
Therapy partial responder 63.83 13.57 45 1001526 10613 62476838
Orthopnoea 63.63 13.57 11 1001560 6250 62481201
Hypertriglyceridaemia 63.60 13.57 11 1001560 6248 62481203
Mental impairment 63.23 13.57 78 1001493 14073 62473378
Nystagmus 63.06 13.57 11 1001560 6209 62481242
Electrocardiogram abnormal 63.01 13.57 33 1001538 9146 62478305
Onychomycosis 62.79 13.57 270 1001301 7662 62479789
Gait inability 62.62 13.57 1179 1000392 51780 62435671
Bronchopulmonary aspergillosis 62.37 13.57 29 1001542 8606 62478845
Abnormal dreams 62.19 13.57 45 1001526 10471 62476980
Eczema 61.87 13.57 280 1001291 32011 62455440
Respiratory syncytial virus infection 61.86 13.57 17 1001554 7001 62480450
Cerebral ischaemia 61.79 13.57 15 1001556 6713 62480738
Middle insomnia 61.58 13.57 65 1001506 12578 62474873
Device occlusion 61.29 13.57 20 1001551 7367 62480084
Hyperreflexia 61.25 13.57 10 1001561 5924 62481527
Rash papular 61.09 13.57 441 1001130 15261 62472190
Thirst 61.07 13.57 79 1001492 13962 62473489
SLE arthritis 60.96 13.57 64 1001507 617 62486834
Pulmonary fibrosis 60.86 13.57 924 1000647 38885 62448566
Miosis 60.85 13.57 20 1001551 7333 62480118
Nephropathy 60.51 13.57 13 1001558 6328 62481123
Peripheral sensory neuropathy 60.38 13.57 21 1001550 7430 62480021
Somnambulism 60.31 13.57 8 1001563 5535 62481916
Restless legs syndrome 60.31 13.57 126 1001445 18405 62469046
Spinal pain 60.06 13.57 384 1001187 12755 62474696
Injection site oedema 59.79 13.57 92 1001479 1340 62486111
Device power source issue 59.69 13.57 59 1001512 526 62486925
Left ventricular hypertrophy 59.47 13.57 7 1001564 5308 62482143
Rheumatoid factor negative 59.35 13.57 60 1001511 551 62486900
Hypoventilation 59.28 13.57 4 1001567 4750 62482701
Nasal polyps 58.41 13.57 12 1001559 6027 62481424
Breast cancer metastatic 58.30 13.57 62 1001509 11956 62475495
Premature labour 57.92 13.57 67 1001504 12437 62475014
Systemic infection 57.87 13.57 4 1001567 4656 62482795
Major depression 57.80 13.57 27 1001544 7991 62479460
Dermatitis bullous 57.79 13.57 31 1001540 8477 62478974
Nocturia 57.79 13.57 28 1001543 8113 62479338
Guttate psoriasis 57.76 13.57 52 1001519 407 62487044
Duodenal ulcer 57.66 13.57 25 1001546 7731 62479720
Ventricular hypokinesia 57.63 13.57 4 1001567 4640 62482811
Immune thrombocytopenia 57.59 13.57 49 1001522 10507 62476944
Protein urine present 57.48 13.57 13 1001558 6107 62481344
Skin discolouration 57.44 13.57 877 1000694 36951 62450500
Proctalgia 57.35 13.57 13 1001558 6097 62481354
Coma scale abnormal 57.13 13.57 7 1001564 5146 62482305
Throat tightness 57.05 13.57 201 1001370 24686 62462765
Oligohydramnios 56.91 13.57 15 1001556 6351 62481100
Metabolic disorder 56.86 13.57 16 1001555 6487 62480964
Product administration error 56.80 13.57 173 1001398 22224 62465227
Weight fluctuation 56.80 13.57 43 1001528 9776 62477675
Ketoacidosis 56.66 13.57 3 1001568 4375 62483076
Blood calcium increased 56.63 13.57 39 1001532 9311 62478140
Abortion spontaneous 56.53 13.57 474 1001097 46721 62440730
Amnesia 56.36 13.57 582 1000989 55003 62432448
Potentiating drug interaction 56.33 13.57 3 1001568 4353 62483098
Wheelchair user 56.24 13.57 223 1001348 6096 62481355
Abdominal pain upper 55.93 13.57 2673 998898 203771 62283680
Rhinovirus infection 55.92 13.57 4 1001567 4525 62482926
Laryngitis 55.69 13.57 458 1001113 16509 62470942
Aortic valve incompetence 55.69 13.57 13 1001558 5975 62481476
Intestinal ischaemia 55.63 13.57 24 1001547 7444 62480007
Drug level below therapeutic 55.47 13.57 6 1001565 4860 62482591
Animal bite 55.42 13.57 136 1001435 2846 62484605
Bundle branch block left 55.33 13.57 21 1001550 7038 62480413
Aplasia pure red cell 55.29 13.57 4 1001567 4483 62482968
Hypoxic-ischaemic encephalopathy 55.29 13.57 3 1001568 4284 62483167
Surgical failure 55.04 13.57 72 1001499 894 62486557
Application site erythema 55.02 13.57 6 1001565 4829 62482622
Blood phosphorus decreased 54.79 13.57 4 1001567 4449 62483002
Gallbladder operation 54.78 13.57 117 1001454 2226 62485225
Stillbirth 54.74 13.57 19 1001552 6731 62480720
Clonus 54.72 13.57 5 1001566 4631 62482820
Body height decreased 54.71 13.57 47 1001524 10031 62477420
Product physical issue 54.64 13.57 7 1001564 4973 62482478
Pre-existing condition improved 54.61 13.57 31 1001540 8213 62479238
Spinal compression fracture 54.59 13.57 88 1001483 14195 62473256
Serum ferritin increased 54.45 13.57 15 1001556 6167 62481284
Feeling abnormal 54.44 13.57 2863 998708 145529 62341922
Unintended pregnancy 54.41 13.57 15 1001556 6164 62481287
Muscle twitching 54.23 13.57 146 1001425 19522 62467929
Pseudomonas infection 54.22 13.57 58 1001513 11155 62476296
Ecchymosis 54.08 13.57 57 1001514 11037 62476414
Pemphigoid 54.08 13.57 24 1001547 7320 62480131
Musculoskeletal deformity 53.78 13.57 103 1001468 1806 62485645
Low turnover osteopathy 53.75 13.57 3 1001568 4182 62483269
Femoral neck fracture 53.71 13.57 34 1001537 8489 62478962
Petechiae 53.71 13.57 85 1001486 13812 62473639
Pulmonary haemorrhage 53.62 13.57 23 1001548 7158 62480293
Venous thrombosis 53.52 13.57 7 1001564 4895 62482556
Brain injury 53.48 13.57 22 1001549 7021 62480430
Ileus paralytic 53.48 13.57 5 1001566 4546 62482905
Peritonitis bacterial 53.19 13.57 7 1001564 4872 62482579
Rebound effect 53.11 13.57 5 1001566 4521 62482930
Aortic arteriosclerosis 52.96 13.57 16 1001555 6193 62481258
Upper respiratory tract congestion 52.69 13.57 108 1001463 1994 62485457
Iron deficiency 52.65 13.57 24 1001547 7206 62480245
Bundle branch block right 52.54 13.57 8 1001563 4990 62482461
Elbow operation 52.32 13.57 43 1001528 293 62487158
Tendon operation 51.92 13.57 42 1001529 279 62487172
Obsessive-compulsive disorder 51.87 13.57 3 1001568 4057 62483394
Supraventricular extrasystoles 51.45 13.57 6 1001565 4583 62482868
Kidney infection 51.45 13.57 576 1000995 22600 62464851
Escherichia urinary tract infection 51.31 13.57 68 1001503 11894 62475557
Oral mucosal exfoliation 51.29 13.57 93 1001478 1561 62485890
Skin mass 51.28 13.57 208 1001363 5747 62481704
Induration 51.20 13.57 83 1001488 1267 62486184
Systemic lupus erythematosus rash 50.99 13.57 111 1001460 2141 62485310
Meniscus injury 50.91 13.57 235 1001336 6879 62480572
Neck surgery 50.74 13.57 99 1001472 1761 62485690
Systemic inflammatory response syndrome 50.72 13.57 13 1001558 5608 62481843
Foetal death 50.68 13.57 59 1001512 10921 62476530
Blood thyroid stimulating hormone increased 50.67 13.57 25 1001546 7169 62480282
Cholecystitis acute 50.63 13.57 34 1001537 8226 62479225
Pneumonia fungal 50.42 13.57 12 1001559 5443 62482008
Joint surgery 50.40 13.57 45 1001526 348 62487103
Procedural pain 50.25 13.57 173 1001398 21396 62466055
Pathogen resistance 50.21 13.57 19 1001552 6379 62481072
Dyslipidaemia 50.13 13.57 27 1001544 7366 62480085
Graft versus host disease 49.96 13.57 22 1001549 6741 62480710
Catatonia 49.84 13.57 6 1001565 4471 62482980
Cardiovascular disorder 49.80 13.57 68 1001503 11744 62475707
Azotaemia 49.75 13.57 6 1001565 4465 62482986
Periorbital oedema 49.67 13.57 14 1001557 5670 62481781
Blood chloride decreased 49.65 13.57 13 1001558 5529 62481922
Maternal drugs affecting foetus 49.51 13.57 11 1001560 5231 62482220
Personality change 49.47 13.57 24 1001547 6949 62480502
Eye movement disorder 49.32 13.57 11 1001560 5217 62482234
Hot flush 49.31 13.57 542 1001029 50617 62436834
Intestinal perforation 49.31 13.57 70 1001501 11893 62475558
Bedridden 49.30 13.57 321 1001250 10730 62476721
Hyperuricaemia 49.27 13.57 12 1001559 5358 62482093
Central nervous system lesion 49.24 13.57 57 1001514 10578 62476873
Chronic sinusitis 49.21 13.57 79 1001492 12764 62474687
Tongue oedema 49 13.57 7 1001564 4579 62482872
Respiration abnormal 48.80 13.57 20 1001551 6397 62481054
Euphoric mood 48.77 13.57 9 1001562 4878 62482573
Injection site hypoaesthesia 48.64 13.57 49 1001522 448 62487003
Skin toxicity 48.53 13.57 8 1001563 4706 62482745
Bunion operation 48.41 13.57 80 1001491 1242 62486209
Odynophagia 48.38 13.57 29 1001542 7457 62479994
Malignant melanoma 48.33 13.57 326 1001245 11030 62476421
Pyelonephritis 48.24 13.57 133 1001438 17645 62469806
Sexual dysfunction 48.13 13.57 6 1001565 4353 62483098
Cyst 48.13 13.57 384 1001187 13715 62473736
Pollakiuria 47.88 13.57 252 1001319 27685 62459766
Granuloma skin 47.87 13.57 261 1001310 8176 62479275
International normalised ratio decreased 47.79 13.57 7 1001564 4494 62482957
Diverticulum intestinal 47.78 13.57 23 1001548 6690 62480761
Device dispensing error 47.65 13.57 28 1001543 100 62487351
Diverticulum 47.62 13.57 72 1001499 11919 62475532
Panniculitis 47.36 13.57 325 1001246 11060 62476391
Hypogammaglobulinaemia 47.26 13.57 27 1001544 7128 62480323
Endodontic procedure 47.12 13.57 134 1001437 3073 62484378
Cerebral atrophy 47.11 13.57 11 1001560 5055 62482396
Tumour marker increased 47.06 13.57 10 1001561 4905 62482546
Depressive symptom 46.91 13.57 5 1001566 4097 62483354
Cataract operation 46.86 13.57 192 1001379 5330 62482121
Blood culture positive 46.65 13.57 9 1001562 4726 62482725
Blindness 46.63 13.57 180 1001391 21519 62465932
Blood parathyroid hormone decreased 46.53 13.57 289 1001282 9502 62477949
Spinal column injury 46.33 13.57 101 1001470 1950 62485501
Gastric ulcer 46.30 13.57 208 1001363 23829 62463622
Culture urine positive 46.27 13.57 3 1001568 3684 62483767
Thrombocytosis 46.12 13.57 17 1001554 5801 62481650
Amenorrhoea 46.05 13.57 53 1001518 9861 62477590
Toe operation 46.03 13.57 59 1001512 717 62486734
Blood pressure systolic decreased 45.95 13.57 30 1001541 7367 62480084
Blood pressure inadequately controlled 45.91 13.57 11 1001560 4967 62482484
Post procedural haemorrhage 45.91 13.57 35 1001536 7929 62479522
Haemorrhagic stroke 45.79 13.57 17 1001554 5775 62481676
Swelling face 45.56 13.57 715 1000856 62760 62424691
Gastroenteritis viral 45.54 13.57 573 1000998 23127 62464324
Exercise tolerance decreased 45.40 13.57 15 1001556 5482 62481969
Disturbance in social behaviour 45.33 13.57 5 1001566 3988 62483463
Brain natriuretic peptide increased 45.26 13.57 13 1001558 5200 62482251
Candida infection 45.16 13.57 262 1001309 28089 62459362
Vaginal discharge 45.13 13.57 47 1001524 9151 62478300
Cachexia 44.94 13.57 17 1001554 5709 62481742
Cytomegalovirus infection reactivation 44.89 13.57 5 1001566 3958 62483493
Back pain 44.88 13.57 4792 996779 259353 62228098
Tachyarrhythmia 44.83 13.57 8 1001563 4442 62483009
Ankylosing spondylitis 44.77 13.57 301 1001270 10173 62477278
Disease recurrence 44.66 13.57 259 1001312 27771 62459680
Bone swelling 44.65 13.57 89 1001482 1609 62485842
Carpal tunnel decompression 44.64 13.57 63 1001508 845 62486606
Diarrhoea haemorrhagic 44.59 13.57 46 1001525 8996 62478455
Lip oedema 44.32 13.57 5 1001566 3919 62483532
Patent ductus arteriosus 44.23 13.57 7 1001564 4243 62483208
Dyspnoea at rest 44.12 13.57 6 1001565 4073 62483378
Atrial tachycardia 44.09 13.57 7 1001564 4233 62483218
Respiratory rate decreased 44 13.57 3 1001568 3532 62483919
Blood prolactin increased 43.52 13.57 3 1001568 3500 62483951
Ammonia increased 43.51 13.57 10 1001561 4646 62482805
Helicobacter infection 43.39 13.57 1834 999737 90951 62396500
Musculoskeletal discomfort 43.33 13.57 454 1001117 17513 62469938
Blood immunoglobulin E increased 43.24 13.57 5 1001566 3844 62483607
Electrocardiogram T wave inversion 43.19 13.57 3 1001568 3478 62483973
Ischaemia 43.13 13.57 11 1001560 4761 62482690
Pelvic pain 43.09 13.57 93 1001478 13426 62474025
Skin reaction 43.07 13.57 390 1001181 14459 62472992
Eye operation 42.84 13.57 107 1001464 2265 62485186
Latent tuberculosis 42.80 13.57 114 1001457 2513 62484938
Peripheral ischaemia 42.66 13.57 12 1001559 4866 62482585
Blood thyroid stimulating hormone decreased 42.61 13.57 10 1001561 4580 62482871
Joint dislocation 42.53 13.57 469 1001102 18331 62469120
Physical disability 42.52 13.57 117 1001454 2631 62484820
Gastritis erosive 42.52 13.57 21 1001550 6018 62481433
Wrong product administered 42.27 13.57 22 1001549 6119 62481332
Endophthalmitis 42.06 13.57 4 1001567 3588 62483863
Haemophagocytic lymphohistiocytosis 42.02 13.57 64 1001507 10563 62476888
Sensory disturbance 41.98 13.57 96 1001475 13576 62473875
Intracranial pressure increased 41.90 13.57 15 1001556 5212 62482239
Sensitisation 41.78 13.57 3 1001568 3383 62484068
Pruritus 41.78 13.57 6404 995167 355049 62132402
Blood glucose decreased 41.76 13.57 179 1001392 20773 62466678
Ventricular septal defect 41.73 13.57 9 1001562 4369 62483082
Blood creatine increased 41.72 13.57 18 1001553 5583 62481868
Laryngeal oedema 41.61 13.57 19 1001552 5699 62481752
Diverticulitis 41.51 13.57 865 1000706 38692 62448759
Staphylococcus test positive 41.50 13.57 6 1001565 3890 62483561
Splenomegaly 41.47 13.57 70 1001501 11087 62476364
Vulvovaginal mycotic infection 41.43 13.57 186 1001385 5380 62482071
Oxygen consumption increased 41.33 13.57 6 1001565 3878 62483573
Infusion related reaction 41.23 13.57 3323 998248 242198 62245253
Pre-eclampsia 41.17 13.57 50 1001521 9083 62478368
Drooling 41.11 13.57 6 1001565 3862 62483589
Lymphoedema 41.07 13.57 76 1001495 11616 62475835
Polycystic ovaries 41.00 13.57 10 1001561 4461 62482990
Contrast media allergy 40.96 13.57 106 1001465 2295 62485156
Back disorder 40.91 13.57 306 1001265 10711 62476740
Injection site coldness 40.64 13.57 23 1001548 75 62487376
Local reaction 40.64 13.57 53 1001518 656 62486795
Portal hypertension 40.41 13.57 6 1001565 3813 62483638
Embolism 40.39 13.57 39 1001532 7867 62479584
Protein total decreased 40.28 13.57 22 1001549 5955 62481496
Erythema 40.17 13.57 3257 998314 172494 62314957
Neutrophilia 40.12 13.57 10 1001561 4396 62483055
Breast cancer stage I 40.07 13.57 30 1001541 6859 62480592
Drug tolerance decreased 40.04 13.57 437 1001134 17036 62470415
Dermatitis exfoliative 39.94 13.57 18 1001553 5441 62482010
Embolic stroke 39.80 13.57 6 1001565 3770 62483681
Pulmonary arterial pressure increased 39.57 13.57 5 1001566 3590 62483861
Hydrocephalus 39.53 13.57 17 1001554 5283 62482168
Wrist deformity 39.44 13.57 97 1001474 2033 62485418
Pruritus allergic 39.32 13.57 81 1001490 1501 62485950
Red cell distribution width increased 39.14 13.57 66 1001505 10458 62476993
Polydipsia 39.13 13.57 5 1001566 3559 62483892
Escherichia bacteraemia 39.07 13.57 7 1001564 3876 62483575
Enthesopathy 38.91 13.57 251 1001320 8363 62479088
Injection site dryness 38.70 13.57 40 1001531 378 62487073
Infection susceptibility increased 38.68 13.57 133 1001438 3388 62484063
Lung consolidation 38.58 13.57 9 1001562 4139 62483312
Pharyngeal swelling 38.40 13.57 27 1001544 6377 62481074
Pneumonia bacterial 38.40 13.57 56 1001515 9409 62478042
Human antichimeric antibody positive 38.26 13.57 84 1001487 1630 62485821
Non-cardiac chest pain 38.20 13.57 26 1001545 6246 62481205
Phlebitis 38.19 13.57 30 1001541 6694 62480757
Device defective 38.09 13.57 91 1001480 1871 62485580
Hypopnoea 38.00 13.57 7 1001564 3799 62483652
Flank pain 37.98 13.57 132 1001439 16278 62471173
Lung transplant 37.95 13.57 3 1001568 3125 62484326
Obstruction 37.93 13.57 3 1001568 3124 62484327
Body height below normal 37.89 13.57 97 1001474 2086 62485365
Fluid intake reduced 37.89 13.57 6 1001565 3635 62483816
Cardiac tamponade 37.77 13.57 14 1001557 4761 62482690
White blood cells urine positive 37.75 13.57 17 1001554 5141 62482310
Injection site anaesthesia 37.70 13.57 17 1001554 28 62487423
Large intestine perforation 37.64 13.57 47 1001524 8435 62479016
Neurogenic bladder 37.58 13.57 4 1001567 3281 62484170
Malabsorption 37.55 13.57 9 1001562 4063 62483388
Hypoaesthesia oral 37.26 13.57 95 1001476 12938 62474513
Application site pain 37.11 13.57 10 1001561 4172 62483279
Eating disorder 36.96 13.57 164 1001407 18852 62468599
Abdominal wall haematoma 36.87 13.57 3 1001568 3052 62484399
Faeces soft 36.85 13.57 22 1001549 5670 62481781
Disability assessment scale score increased 36.82 13.57 4 1001567 3229 62484222
Occupational exposure to product 36.76 13.57 93 1001478 1985 62485466
Scar excision 36.76 13.57 20 1001551 59 62487392
Coordination abnormal 36.66 13.57 104 1001467 13669 62473782
Sinus node dysfunction 36.62 13.57 14 1001557 4671 62482780
Sensitivity to weather change 36.54 13.57 217 1001354 7020 62480431
Mass excision 36.50 13.57 36 1001535 320 62487131
Clostridium test positive 36.36 13.57 4 1001567 3197 62484254
Urticaria 36.35 13.57 3063 998508 162739 62324712
Performance status decreased 36.22 13.57 7 1001564 3671 62483780
General symptom 36.19 13.57 112 1001459 2696 62484755
Oral candidiasis 36.14 13.57 211 1001360 22587 62464864
Pathological fracture 36.10 13.57 52 1001519 8782 62478669
Dental care 36.04 13.57 63 1001508 1026 62486425
Muscle haemorrhage 36.04 13.57 4 1001567 3175 62484276
Adjustment disorder 36.02 13.57 4 1001567 3174 62484277
Motor dysfunction 36.01 13.57 72 1001499 10689 62476762
Urine analysis abnormal 35.99 13.57 17 1001554 4999 62482452
Lung opacity 35.88 13.57 4 1001567 3164 62484287
Lymphocyte percentage decreased 35.83 13.57 3 1001568 2982 62484469
Hypokinesia 35.80 13.57 107 1001464 13829 62473622
Inflammatory marker increased 35.78 13.57 207 1001364 6632 62480819
Tooth abscess 35.52 13.57 377 1001194 14592 62472859
Platelet count increased 35.49 13.57 151 1001420 17560 62469891
Skin hyperpigmentation 35.46 13.57 25 1001546 5896 62481555
Breath sounds abnormal 35.38 13.57 75 1001496 10898 62476553
Metastases to lymph nodes 35.37 13.57 46 1001525 8112 62479339
Product administration interrupted 35.30 13.57 16 1001555 4820 62482631
Impaired quality of life 35.28 13.57 106 1001465 13677 62473774
Joint laxity 35.28 13.57 102 1001469 2362 62485089
Neutrophil percentage increased 35.21 13.57 3 1001568 2940 62484511
Thyroid neoplasm 35.10 13.57 141 1001430 3878 62483573
Acute graft versus host disease 35.00 13.57 13 1001558 4415 62483036
Drug abuser 34.92 13.57 3 1001568 2920 62484531
Periorbital swelling 34.84 13.57 3 1001568 2915 62484536
Pulmonary alveolar haemorrhage 34.78 13.57 15 1001556 4653 62482798
Duodenal ulcer perforation 34.73 13.57 1696 999875 85513 62401938
Incoherent 34.64 13.57 14 1001557 4516 62482935
Cystitis haemorrhagic 34.50 13.57 11 1001560 4112 62483339
Product availability issue 34.47 13.57 11 1001560 4110 62483341
Rheumatoid lung 34.41 13.57 136 1001435 3712 62483739
Thrombotic thrombocytopenic purpura 34.37 13.57 9 1001562 3827 62483624
Spider vein 34.36 13.57 33 1001538 283 62487168
Dermatitis allergic 34.32 13.57 378 1001193 14770 62472681
Cerebellar syndrome 34.30 13.57 7 1001564 3532 62483919
Lymphoma 34.29 13.57 318 1001253 11869 62475582
Occult blood positive 34.06 13.57 8 1001563 3662 62483789
Intermenstrual bleeding 34.05 13.57 45 1001526 7881 62479570
Pulmonary function test decreased 33.98 13.57 10 1001561 3937 62483514
Faecal calprotectin increased 33.96 13.57 5 1001566 3198 62484253
Stridor 33.90 13.57 7 1001564 3503 62483948
Hyperventilation 33.85 13.57 28 1001543 6088 62481363
Dental operation 33.80 13.57 69 1001502 1270 62486181
Bone lesion 33.70 13.57 26 1001545 5855 62481596
Myositis 33.65 13.57 59 1001512 9207 62478244
Gastrointestinal perforation 33.63 13.57 7 1001564 3484 62483967
Renal cyst 33.56 13.57 70 1001501 10232 62477219
Hyperpyrexia 33.55 13.57 8 1001563 3624 62483827
Drug screen positive 33.51 13.57 8 1001563 3621 62483830
Immune reconstitution inflammatory syndrome 33.49 13.57 28 1001543 6056 62481395
Rash morbilliform 33.45 13.57 6 1001565 3319 62484132
Escherichia infection 33.44 13.57 97 1001474 12657 62474794
Vitamin D deficiency 33.34 13.57 110 1001461 13782 62473669
Arterial occlusive disease 33.31 13.57 27 1001544 5931 62481520
Injection site cellulitis 33.30 13.57 66 1001505 1188 62486263
Hepatitis fulminant 33.26 13.57 7 1001564 3457 62483994
Fibrin D dimer increased 33.24 13.57 19 1001552 5015 62482436
Cardiac failure chronic 33.23 13.57 14 1001557 4404 62483047
Anger 33.19 13.57 94 1001477 12362 62475089
Galactorrhoea 33.17 13.57 12 1001559 4143 62483308
International normalised ratio abnormal 33.15 13.57 6 1001565 3298 62484153
Blood phosphorus increased 33.14 13.57 5 1001566 3140 62484311
Sensory loss 32.99 13.57 70 1001501 10168 62477283
Ventricular hypertrophy 32.88 13.57 7 1001564 3429 62484022
Feeling cold 32.80 13.57 231 1001340 23657 62463794
Mucous stools 32.70 13.57 13 1001558 4235 62483216
Stress at work 32.63 13.57 64 1001507 1143 62486308
Thrombophlebitis 32.60 13.57 14 1001557 4354 62483097
Self-medication 32.56 13.57 3 1001568 2760 62484691
Eyelid ptosis 32.53 13.57 40 1001531 7227 62480224
Intervertebral disc protrusion 32.35 13.57 540 1001031 23169 62464282
Focal dyscognitive seizures 32.31 13.57 4 1001567 2917 62484534
Mammoplasty 32.26 13.57 42 1001529 519 62486932
Scleritis 32.23 13.57 147 1001424 4281 62483170
Tenosynovitis 32.06 13.57 346 1001225 13449 62474002
Biliary dyskinesia 32.06 13.57 3 1001568 2726 62484725
Petit mal epilepsy 31.96 13.57 10 1001561 3784 62483667
Extrasystoles 31.95 13.57 21 1001550 5139 62482312
Initial insomnia 31.89 13.57 30 1001541 6127 62481324
Necrosis 31.78 13.57 24 1001547 5463 62481988
Juvenile idiopathic arthritis 31.74 13.57 120 1001451 3206 62484245
Abnormal faeces 31.70 13.57 24 1001547 5456 62481995
Behaviour disorder 31.69 13.57 6 1001565 3193 62484258
Epidural injection 31.65 13.57 10 1001561 0 62487451
Lupus-like syndrome 31.65 13.57 375 1001196 14920 62472531
Post procedural infection 31.65 13.57 254 1001317 9088 62478363
Peripheral coldness 31.54 13.57 93 1001478 12072 62475379
Abdominal tenderness 31.51 13.57 50 1001521 8116 62479335
Streptococcal infection 31.48 13.57 177 1001394 5610 62481841
Injection site pustule 31.48 13.57 20 1001551 85 62487366
Blood chloride increased 31.40 13.57 3 1001568 2681 62484770
Osteoporosis 31.40 13.57 1153 1000418 56185 62431266
Nerve injury 31.32 13.57 266 1001305 9680 62477771
Gallbladder disorder 31.16 13.57 172 1001399 18670 62468781
Anaemia macrocytic 31.14 13.57 8 1001563 3446 62484005
Swelling of eyelid 31.09 13.57 6 1001565 3150 62484301
Bilirubin conjugated increased 31.05 13.57 4 1001567 2830 62484621
Congestive cardiomyopathy 31.00 13.57 31 1001540 6151 62481300
Endocarditis 30.99 13.57 27 1001544 5723 62481728
Movement disorder 30.96 13.57 207 1001364 21454 62465997
Injection site exfoliation 30.93 13.57 34 1001537 347 62487104
Exposure via skin contact 30.92 13.57 35 1001536 370 62487081
Neonatal respiratory distress syndrome 30.82 13.57 4 1001567 2814 62484637
Oesophageal pain 30.74 13.57 10 1001561 3691 62483760
Neoplasm recurrence 30.73 13.57 3 1001568 2635 62484816
Low density lipoprotein increased 30.61 13.57 33 1001538 6324 62481127
Areflexia 30.57 13.57 6 1001565 3112 62484339
Accident 30.54 13.57 181 1001390 5851 62481600
Post transplant lymphoproliferative disorder 30.45 13.57 21 1001550 5010 62482441
Persecutory delusion 30.42 13.57 4 1001567 2786 62484665
Aphthous ulcer 30.35 13.57 115 1001456 13823 62473628
Chronic graft versus host disease 30.34 13.57 6 1001565 3096 62484355
Aortic stenosis 30.32 13.57 21 1001550 4999 62482452
Pain in jaw 30.20 13.57 493 1001078 43003 62444448
Colonoscopy 30.19 13.57 73 1001498 1513 62485938
Ocular icterus 30.15 13.57 10 1001561 3646 62483805
Tenoplasty 30.14 13.57 17 1001554 55 62487396
Knee deformity 30.12 13.57 66 1001505 1279 62486172
Psychiatric symptom 30.05 13.57 23 1001548 5200 62482251
Exposed bone in jaw 30.03 13.57 5 1001566 2920 62484531
Colorectal cancer 30.01 13.57 10 1001561 3635 62483816
Duodenitis 29.98 13.57 11 1001560 3764 62483687
Coronary artery occlusion 29.89 13.57 52 1001519 8139 62479312
Sciatica 29.88 13.57 731 1000840 33593 62453858
Immobile 29.88 13.57 178 1001393 5765 62481686
Ankle arthroplasty 29.87 13.57 79 1001492 1734 62485717
Plasmacytoma 29.86 13.57 3 1001568 2576 62484875
Loose body in joint 29.82 13.57 64 1001507 1222 62486229
Hypoglycaemic coma 29.81 13.57 3 1001568 2572 62484879
Retinal haemorrhage 29.73 13.57 21 1001550 4948 62482503
Hip fracture 29.71 13.57 309 1001262 29165 62458286
Rotator cuff syndrome 29.71 13.57 335 1001236 13167 62474284
Polyarthritis 29.69 13.57 267 1001304 9879 62477572
Scab 29.61 13.57 217 1001354 7546 62479905
Progressive multifocal leukoencephalopathy 29.57 13.57 105 1001466 12866 62474585
Purpura 29.55 13.57 87 1001484 11298 62476153
Skin laceration 29.46 13.57 513 1001058 22195 62465256
Hepatic lesion 29.39 13.57 20 1001551 4805 62482646
Mucormycosis 29.27 13.57 5 1001566 2866 62484585
Increased appetite 29.26 13.57 68 1001503 9562 62477889
Conjunctival haemorrhage 29.26 13.57 10 1001561 3577 62483874
Synovial cyst 29.24 13.57 272 1001299 10161 62477290
Cytomegalovirus test positive 29.18 13.57 6 1001565 3012 62484439
Glycosylated haemoglobin increased 29.18 13.57 99 1001472 12299 62475152
Left ventricular failure 29.11 13.57 28 1001543 5659 62481792
Fracture 29.08 13.57 185 1001386 19399 62468052
Product preparation error 28.92 13.57 32 1001539 6060 62481391
Cholangitis 28.91 13.57 27 1001544 5534 62481917
Eye infection 28.87 13.57 306 1001265 11839 62475612
Anal fistula 28.79 13.57 10 1001561 3541 62483910
Injection site scar 28.77 13.57 55 1001516 963 62486488
Urine ketone body present 28.76 13.57 3 1001568 2500 62484951
Self-injurious ideation 28.55 13.57 4 1001567 2655 62484796
Cold sweat 28.49 13.57 96 1001475 11951 62475500
Pseudomembranous colitis 28.46 13.57 7 1001564 3105 62484346
Skin papilloma 28.38 13.57 154 1001417 4815 62482636
Exposure to communicable disease 28.36 13.57 41 1001530 563 62486888
Rotator cuff repair 28.33 13.57 86 1001485 2048 62485403
Nail disorder 28.22 13.57 322 1001249 12693 62474758
Bone graft 28.11 13.57 53 1001518 918 62486533
Tonsillar ulcer 28.06 13.57 29 1001542 274 62487177
Basal cell carcinoma 28.05 13.57 608 1000963 27383 62460068
Exposure to toxic agent 28.03 13.57 28 1001543 5559 62481892
Urine abnormality 28.02 13.57 42 1001529 6977 62480474
Ovarian neoplasm 27.89 13.57 51 1001520 862 62486589
Malignant pleural effusion 27.79 13.57 4 1001567 2602 62484849
Papule 27.68 13.57 169 1001402 5522 62481929
Urinary tract infection bacterial 27.67 13.57 24 1001547 5098 62482353
Radiculopathy 27.64 13.57 59 1001512 8552 62478899
Carpal tunnel syndrome 27.63 13.57 472 1001099 20345 62467106
Haemoperitoneum 27.46 13.57 5 1001566 2736 62484715
Visual field defect 27.43 13.57 38 1001533 6523 62480928
Laryngospasm 27.33 13.57 7 1001564 3021 62484430
Bacterial test positive 27.32 13.57 26 1001545 5281 62482170
Periodontitis 27.30 13.57 9 1001562 3294 62484157
Leukoencephalopathy 27.27 13.57 18 1001553 4395 62483056
Pyelonephritis acute 27.26 13.57 20 1001551 4621 62482830
Dactylitis 27.25 13.57 97 1001474 2515 62484936
Gastrointestinal sounds abnormal 27.17 13.57 15 1001556 4036 62483415
Coronary artery stenosis 27.15 13.57 21 1001550 4723 62482728
Lacunar infarction 27.00 13.57 9 1001562 3271 62484180
Pulmonary thrombosis 26.80 13.57 61 1001510 8641 62478810
Hepatitis toxic 26.65 13.57 9 1001562 3244 62484207
Ventricular dysfunction 26.58 13.57 6 1001565 2822 62484629
Tooth extraction 26.49 13.57 263 1001308 10001 62477450
Wound dehiscence 26.45 13.57 23 1001548 4880 62482571
Autonomic nervous system imbalance 26.44 13.57 6 1001565 2812 62484639
Escherichia sepsis 26.40 13.57 24 1001547 4983 62482468
Bicytopenia 26.36 13.57 4 1001567 2501 62484950
Dry mouth 26.35 13.57 983 1000588 76880 62410571
Staphylococcal bacteraemia 26.30 13.57 29 1001542 5501 62481950
Anal fissure 26.29 13.57 19 1001552 4424 62483027
Diabetic retinopathy 26.20 13.57 3 1001568 2324 62485127
Diffuse large B-cell lymphoma recurrent 26.10 13.57 3 1001568 2317 62485134
Tension headache 26.01 13.57 26 1001545 5160 62482291
Epstein-Barr virus infection 25.97 13.57 55 1001516 7995 62479456
Dental implantation 25.97 13.57 44 1001527 698 62486753
Ischaemic cardiomyopathy 25.96 13.57 4 1001567 2473 62484978
Intervertebral disc operation 25.94 13.57 48 1001523 819 62486632
Dissociation 25.86 13.57 7 1001564 2912 62484539
Carotid artery stenosis 25.84 13.57 26 1001545 5144 62482307
Duodenal ulcer haemorrhage 25.82 13.57 4 1001567 2463 62484988
Iridocyclitis 25.75 13.57 93 1001478 2429 62485022
Thinking abnormal 25.73 13.57 84 1001487 10559 62476892
Clostridial infection 25.71 13.57 19 1001552 4373 62483078
Haemarthrosis 25.46 13.57 9 1001562 3152 62484299
Paraesthesia 25.33 13.57 2131 999440 154835 62332616
Heavy menstrual bleeding 25.33 13.57 170 1001401 17603 62469848
Burn infection 25.24 13.57 15 1001556 55 62487396
Appendicitis 25.09 13.57 58 1001513 8171 62479280
Gangrene 25.06 13.57 36 1001535 6087 62481364
Small for dates baby 25.00 13.57 14 1001557 3737 62483714
Arthropod sting 24.98 13.57 57 1001514 1136 62486315
Parosmia 24.90 13.57 37 1001534 6169 62481282
Device related sepsis 24.90 13.57 17 1001554 4077 62483374
Pseudomonal sepsis 24.89 13.57 4 1001567 2397 62485054
Injection site erosion 24.84 13.57 16 1001555 70 62487381
Neoplasm malignant 24.82 13.57 632 1000939 29229 62458222
Oral surgery 24.79 13.57 58 1001513 1176 62486275
Dysphoria 24.79 13.57 25 1001546 4941 62482510
Cardiopulmonary failure 24.77 13.57 13 1001558 3599 62483852
Mesenteritis 24.73 13.57 28 1001543 296 62487155
Skin injury 24.68 13.57 72 1001499 1676 62485775
Injection site infection 24.58 13.57 77 1001494 1866 62485585
Hypertonic bladder 24.48 13.57 13 1001558 3575 62483876
Extravasation 24.48 13.57 4 1001567 2368 62485083
Eyelid oedema 24.45 13.57 84 1001487 10395 62477056
Urinary sediment present 24.41 13.57 3 1001568 2200 62485251
Intentional dose omission 24.40 13.57 214 1001357 7861 62479590
Bipolar disorder 24.35 13.57 56 1001515 7904 62479547
Electric shock 24.32 13.57 60 1001511 1260 62486191
Acute graft versus host disease in skin 24.31 13.57 12 1001559 3440 62484011
Reversible cerebral vasoconstriction syndrome 24.27 13.57 6 1001565 2652 62484799
Oral pain 24.21 13.57 309 1001262 28085 62459366
Spinal cord compression 24.21 13.57 18 1001553 4130 62483321
Red blood cell sedimentation rate 24.16 13.57 145 1001426 4709 62482742
Feeling hot 24.14 13.57 998 1000573 49356 62438095
Rheumatic fever 24.11 13.57 869 1000702 42242 62445209
Communication disorder 24.11 13.57 5 1001566 2495 62484956
Decreased activity 24.10 13.57 39 1001532 6281 62481170
Epicondylitis 24.08 13.57 83 1001488 2117 62485334
Subileus 24.03 13.57 10 1001561 3169 62484282
Microcytic anaemia 24.03 13.57 12 1001559 3417 62484034
Neurological decompensation 24.00 13.57 6 1001565 2632 62484819
Breast cancer stage II 23.97 13.57 65 1001506 8671 62478780
Metastasis 23.91 13.57 28 1001543 5169 62482282
Blood parathyroid hormone increased 23.88 13.57 9 1001562 3029 62484422
Micturition urgency 23.83 13.57 75 1001496 9536 62477915
Cross sensitivity reaction 23.81 13.57 3 1001568 2159 62485292
Reaction to preservatives 23.79 13.57 23 1001548 199 62487252
Amyotrophic lateral sclerosis 23.73 13.57 55 1001516 1108 62486343
Generalised oedema 23.71 13.57 149 1001422 15669 62471782
Macular oedema 23.71 13.57 16 1001555 3861 62483590
Growth failure 23.70 13.57 28 1001543 311 62487140
Intra-abdominal haemorrhage 23.69 13.57 5 1001566 2464 62484987
Cardiac dysfunction 23.68 13.57 4 1001567 2311 62485140
SARS-CoV-2 test positive 23.59 13.57 58 1001513 7998 62479453
Alcohol abuse 23.58 13.57 3 1001568 2143 62485308
Metastases to meninges 23.51 13.57 6 1001565 2596 62484855
Cell death 23.50 13.57 6 1001565 2595 62484856
Orthosis user 23.40 13.57 19 1001552 127 62487324
Affective disorder 23.36 13.57 38 1001533 6108 62481343
Dilatation ventricular 23.36 13.57 5 1001566 2440 62485011
Social avoidant behaviour 23.24 13.57 9 1001562 2979 62484472
Drug effective for unapproved indication 23.23 13.57 12 1001559 3352 62484099
Prosthesis user 23.22 13.57 15 1001556 66 62487385
Intraventricular haemorrhage 23.21 13.57 3 1001568 2117 62485334
Coronavirus infection 23.16 13.57 20 1001551 4258 62483193
Nail pitting 23.12 13.57 27 1001544 296 62487155
Lactose intolerance 23.11 13.57 9 1001562 2969 62484482
Anxiety disorder 23.09 13.57 18 1001553 4032 62483419
Immune-mediated enterocolitis 23.08 13.57 3 1001568 2108 62485343
Menopause 23.01 13.57 97 1001474 2728 62484723
Pneumonia klebsiella 23 13.57 5 1001566 2414 62485037
Lack of injection site rotation 22.96 13.57 32 1001539 424 62487027
Injection site plaque 22.95 13.57 19 1001552 131 62487320
Staphylococcal infection 22.93 13.57 831 1000740 40425 62447026
Small intestinal haemorrhage 22.81 13.57 3 1001568 2089 62485362
Haemoglobin abnormal 22.78 13.57 28 1001543 5060 62482391
Paraparesis 22.74 13.57 4 1001567 2244 62485207
Metastases to peritoneum 22.72 13.57 13 1001558 3429 62484022
Onychomadesis 22.71 13.57 164 1001407 5676 62481775
Paralysis 22.66 13.57 80 1001491 9820 62477631
Mass 22.59 13.57 328 1001243 13672 62473779
Gout 22.58 13.57 120 1001451 13151 62474300
Live birth 22.57 13.57 277 1001294 25353 62462098
Animal scratch 22.56 13.57 61 1001510 1357 62486094
Prescription drug used without a prescription 22.55 13.57 5 1001566 2381 62485070
Product administered at inappropriate site 22.52 13.57 104 1001467 3045 62484406
Choking 22.50 13.57 80 1001491 9799 62477652
Acute psychosis 22.48 13.57 6 1001565 2519 62484932
Arthritis infective 22.42 13.57 177 1001394 6301 62481150
Glaucoma 22.38 13.57 421 1001150 18484 62468967
Fatigue 22.29 13.57 14801 986770 873227 61614224
Eye irritation 22.29 13.57 230 1001341 21741 62465710
Caesarean section 22.28 13.57 167 1001404 16865 62470586
Eosinophilic pneumonia 22.22 13.57 4 1001567 2207 62485244
Essential hypertension 22.22 13.57 28 1001543 5005 62482446
Vitreous haemorrhage 22.21 13.57 3 1001568 2047 62485404
Hypoproteinaemia 22.19 13.57 3 1001568 2046 62485405
Haemolytic uraemic syndrome 22.18 13.57 6 1001565 2497 62484954
Arteriospasm coronary 22.16 13.57 18 1001553 3950 62483501
Rhinitis 22.10 13.57 98 1001473 11268 62476183
Autoimmune haemolytic anaemia 22.02 13.57 24 1001547 4577 62482874
Biliary colic 22.02 13.57 15 1001556 3602 62483849
Mean cell haemoglobin concentration decreased 21.96 13.57 15 1001556 3597 62483854
Haemothorax 21.86 13.57 4 1001567 2181 62485270
Refusal of treatment by patient 21.84 13.57 33 1001538 5464 62481987
Red cell distribution width decreased 21.81 13.57 77 1001494 1988 62485463
Red blood cells urine positive 21.81 13.57 11 1001560 3115 62484336
High density lipoprotein decreased 21.65 13.57 4 1001567 2166 62485285
Cyst removal 21.62 13.57 33 1001538 477 62486974
Blood immunoglobulin G decreased 21.58 13.57 6 1001565 2452 62484999
Mood altered 21.52 13.57 140 1001431 14603 62472848
Internal haemorrhage 21.51 13.57 30 1001541 5135 62482316
Monocyte count decreased 21.41 13.57 4 1001567 2149 62485302
Hepatic cyst 21.40 13.57 30 1001541 5124 62482327
Rocky mountain spotted fever 21.34 13.57 11 1001560 28 62487423
Normochromic normocytic anaemia 21.30 13.57 25 1001546 4611 62482840
Dyschezia 21.29 13.57 5 1001566 2289 62485162
Enuresis 21.29 13.57 7 1001564 2566 62484885
Night sweats 21.28 13.57 958 1000613 47856 62439595
Disease susceptibility 21.26 13.57 21 1001550 187 62487264
Mean cell volume increased 21.26 13.57 15 1001556 3536 62483915
Nocardiosis 21.15 13.57 3 1001568 1973 62485478
Spinal stenosis 21.13 13.57 342 1001229 14583 62472868
Humerus fracture 21.12 13.57 71 1001500 8845 62478606
Procedural haemorrhage 21.06 13.57 8 1001563 2680 62484771
Intramedullary rod insertion 20.99 13.57 4 1001567 2119 62485332
Large intestinal stenosis 20.97 13.57 3 1001568 1960 62485491
Bruxism 20.96 13.57 15 1001556 3510 62483941
Nasal discharge discolouration 20.91 13.57 81 1001490 2190 62485261
Bradyarrhythmia 20.88 13.57 4 1001567 2111 62485340
Organ failure 20.85 13.57 8 1001563 2663 62484788
Haemorrhoidal haemorrhage 20.84 13.57 22 1001549 4257 62483194
Gastrointestinal necrosis 20.83 13.57 9 1001562 2789 62484662
Hyperaemia 20.82 13.57 5 1001566 2254 62485197
Injection related reaction 20.79 13.57 42 1001529 767 62486684
Chronic respiratory failure 20.74 13.57 3 1001568 1944 62485507
Vascular access complication 20.70 13.57 77 1001494 2041 62485410
Hypochromic anaemia 20.67 13.57 3 1001568 1939 62485512
Ulcer 20.66 13.57 549 1001022 25558 62461893
Product administered to patient of inappropriate age 20.65 13.57 13 1001558 3255 62484196
Escherichia test positive 20.60 13.57 6 1001565 2378 62485073
Troponin I increased 20.53 13.57 5 1001566 2233 62485218
Non-small cell lung cancer 20.47 13.57 16 1001555 3579 62483872
Neutrophil count abnormal 20.45 13.57 10 1001561 2882 62484569
Retinal toxicity 20.44 13.57 55 1001516 1220 62486231
Maternal exposure during breast feeding 20.44 13.57 22 1001549 4219 62483232
Lower respiratory tract infection viral 20.40 13.57 45 1001526 876 62486575
Megacolon 20.28 13.57 3 1001568 1912 62485539
Pulmonary infarction 20.19 13.57 9 1001562 2738 62484713
Seronegative arthritis 20.17 13.57 119 1001452 3840 62483611
Hepatosplenic T-cell lymphoma 20.11 13.57 35 1001536 568 62486883
Hangnail 20.09 13.57 11 1001560 33 62487418
Lymph node pain 20.08 13.57 59 1001512 1379 62486072
Large intestinal ulcer 20.03 13.57 15 1001556 3429 62484022
Blood sodium increased 20.00 13.57 9 1001562 2723 62484728
Product use complaint 20 13.57 7 1001564 2467 62484984
Gastric ulcer haemorrhage 19.95 13.57 29 1001542 4879 62482572
Cutaneous vasculitis 19.93 13.57 147 1001424 5122 62482329
Central venous catheterisation 19.93 13.57 8 1001563 2591 62484860
Fibrosis 19.92 13.57 22 1001549 4170 62483281
Polyp 19.85 13.57 46 1001525 6475 62480976
Haematocrit increased 19.83 13.57 6 1001565 2320 62485131
Investigation abnormal 19.82 13.57 72 1001499 1886 62485565
Hypertensive emergency 19.81 13.57 3 1001568 1879 62485572
Sputum increased 19.81 13.57 7 1001564 2452 62484999
Haemoglobin increased 19.80 13.57 17 1001554 3629 62483822
Defaecation urgency 19.74 13.57 22 1001549 4153 62483298
Oesophageal candidiasis 19.72 13.57 37 1001534 5626 62481825
Hypertensive heart disease 19.72 13.57 7 1001564 2445 62485006
Craniocerebral injury 19.71 13.57 10 1001561 2822 62484629
Dysaesthesia 19.68 13.57 25 1001546 4453 62482998
Ear congestion 19.64 13.57 91 1001480 2668 62484783
Miliaria 19.63 13.57 53 1001518 1178 62486273
Product prescribing issue 19.59 13.57 9 1001562 2690 62484761
Mean cell haemoglobin increased 19.59 13.57 11 1001560 2932 62484519
Sputum culture positive 19.57 13.57 5 1001566 2162 62485289
Vulvovaginal candidiasis 19.55 13.57 13 1001558 3162 62484289
Left atrial dilatation 19.52 13.57 3 1001568 1858 62485593
Carbohydrate antigen 125 increased 19.51 13.57 10 1001561 2806 62484645
Gastrointestinal stoma complication 19.43 13.57 3 1001568 1852 62485599
Oral herpes 19.42 13.57 544 1001027 25530 62461921
Feeling drunk 19.39 13.57 22 1001549 4120 62483331
Ligament rupture 19.39 13.57 106 1001465 3324 62484127
Bronchiectasis 19.38 13.57 162 1001409 15980 62471471
Liver transplant 19.37 13.57 6 1001565 2285 62485166
Fungal infection 19.35 13.57 738 1000833 36136 62451315
Product label confusion 19.30 13.57 68 1001503 1754 62485697
Compartment syndrome 19.28 13.57 6 1001565 2278 62485173
Prothrombin time shortened 19.22 13.57 4 1001567 1991 62485460
Compression fracture 19.22 13.57 46 1001525 6402 62481049
Anal haemorrhage 19.16 13.57 5 1001566 2131 62485320
Meningitis aseptic 19.11 13.57 29 1001542 4794 62482657
Anticipatory anxiety 19.09 13.57 53 1001518 1198 62486253
Synovectomy 19.09 13.57 19 1001552 171 62487280
Appetite disorder 18.96 13.57 56 1001515 7265 62480186
Mood swings 18.93 13.57 190 1001381 18058 62469393
Right ventricular dysfunction 18.92 13.57 3 1001568 1816 62485635
Jugular vein thrombosis 18.89 13.57 13 1001558 3105 62484346
Transaminases abnormal 18.84 13.57 36 1001535 630 62486821
Tenderness 18.80 13.57 478 1001093 22100 62465351
Cellulitis 18.79 13.57 1079 1000492 80879 62406572
Gastric haemorrhage 18.79 13.57 46 1001525 6352 62481099
Malignant neoplasm of conjunctiva 18.78 13.57 11 1001560 39 62487412
Anaemia postoperative 18.73 13.57 6 1001565 2236 62485215
Hyperparathyroidism 18.70 13.57 10 1001561 2739 62484712
Dizziness postural 18.68 13.57 57 1001514 7319 62480132
Nasal ulcer 18.68 13.57 79 1001492 2225 62485226
Autoimmune hepatitis 18.67 13.57 70 1001501 8440 62479011
Oropharyngeal discomfort 18.65 13.57 34 1001537 5226 62482225
Eructation 18.64 13.57 68 1001503 8265 62479186
Listless 18.59 13.57 11 1001560 2849 62484602
Hearing aid user 18.54 13.57 12 1001559 53 62487398
Infiltration anaesthesia 18.51 13.57 19 1001552 178 62487273
Injection site streaking 18.50 13.57 10 1001561 29 62487422
Intestinal haemorrhage 18.49 13.57 20 1001551 3827 62483624
Hepatitis 18.40 13.57 482 1001089 39306 62448145
Hysterectomy 18.40 13.57 230 1001341 9269 62478182
Alcohol use 18.39 13.57 5 1001566 2074 62485377
Hepatitis B virus test positive 18.35 13.57 20 1001551 202 62487249
Anaphylactoid reaction 18.29 13.57 19 1001552 3704 62483747
Poor quality device used 18.29 13.57 5 1001566 2066 62485385
Bone disorder 18.21 13.57 453 1001118 20873 62466578
Type I hypersensitivity 18.18 13.57 12 1001559 2930 62484521
Herpes simplex 18.17 13.57 68 1001503 8203 62479248
Dermatitis exfoliative generalised 18.07 13.57 20 1001551 3787 62483664
Synovial disorder 18.06 13.57 72 1001499 1973 62485478
Renal artery stenosis 18.04 13.57 4 1001567 1905 62485546
Rash pustular 18.03 13.57 185 1001386 7097 62480354
Angiopathy 18.03 13.57 28 1001543 4585 62482866
Pelvic venous thrombosis 18.02 13.57 3 1001568 1752 62485699
Total lung capacity decreased 17.95 13.57 6 1001565 2177 62485274
Polymyalgia rheumatica 17.90 13.57 20 1001551 3771 62483680
Sleep terror 17.86 13.57 10 1001561 2670 62484781
Hepatotoxicity 17.86 13.57 446 1001125 36595 62450856
Laryngeal disorder 17.77 13.57 46 1001525 996 62486455
Weight bearing difficulty 17.75 13.57 85 1001486 2527 62484924
Blood urine present 17.75 13.57 152 1001419 14917 62472534
Cutaneous T-cell lymphoma 17.74 13.57 55 1001516 1325 62486126
Intervertebral discitis 17.74 13.57 99 1001472 3129 62484322
Quadriparesis 17.73 13.57 5 1001566 2024 62485427
Sunburn 17.72 13.57 89 1001482 2699 62484752
Gingival injury 17.70 13.57 9 1001562 22 62487429
Respiratory symptom 17.70 13.57 16 1001555 3331 62484120
Nephrogenic anaemia 17.68 13.57 6 1001565 2156 62485295
Blood glucose fluctuation 17.67 13.57 28 1001543 4548 62482903
Type IV hypersensitivity reaction 17.67 13.57 12 1001559 2886 62484565
Metastatic bronchial carcinoma 17.62 13.57 15 1001556 108 62487343
Hypersomnia 17.51 13.57 191 1001380 17864 62469587
Injection site discharge 17.47 13.57 41 1001530 833 62486618
Polyhydramnios 17.40 13.57 7 1001564 2264 62485187
Sudden cardiac death 17.40 13.57 6 1001565 2134 62485317
Anosmia 17.39 13.57 53 1001518 6807 62480644
Gastrointestinal motility disorder 17.34 13.57 34 1001537 5085 62482366
Acute lymphocytic leukaemia 17.34 13.57 9 1001562 2507 62484944
Neuralgia 17.29 13.57 296 1001275 25630 62461821
Nephrotic syndrome 17.24 13.57 39 1001532 5537 62481914
Pneumonia influenzal 17.21 13.57 3 1001568 1694 62485757
Crohn's disease 17.20 13.57 32 1001539 4881 62482570
Carbon dioxide decreased 17.15 13.57 6 1001565 2115 62485336
Cerebrovascular disorder 17.08 13.57 11 1001560 2721 62484730
Maternal exposure before pregnancy 17.03 13.57 62 1001509 7541 62479910
Catheterisation cardiac 17.00 13.57 29 1001542 4574 62482877
Peripheral motor neuropathy 16.98 13.57 3 1001568 1678 62485773
Cerebral venous sinus thrombosis 16.97 13.57 5 1001566 1967 62485484
Pulmonary function test abnormal 16.96 13.57 4 1001567 1826 62485625
Swollen joint count increased 16.92 13.57 713 1000858 35341 62452110
Antibody test positive 16.91 13.57 86 1001485 2621 62484830
Stem cell transplant 16.86 13.57 4 1001567 1818 62485633
Oesophageal ulcer 16.85 13.57 28 1001543 4462 62482989
Folate deficiency 16.84 13.57 9 1001562 2466 62484985
Spinal disorder 16.78 13.57 234 1001337 9668 62477783
Injection site hyperaesthesia 16.76 13.57 11 1001560 50 62487401
Trismus 16.75 13.57 22 1001549 3863 62483588
Angle closure glaucoma 16.74 13.57 7 1001564 2212 62485239
Pulmonary sarcoidosis 16.73 13.57 45 1001526 998 62486453
Pelvic inflammatory disease 16.72 13.57 3 1001568 1659 62485792
Tendon disorder 16.71 13.57 153 1001418 5690 62481761
Decreased interest 16.68 13.57 16 1001555 3238 62484213
Neurological symptom 16.65 13.57 42 1001529 5741 62481710
Emotional disorder 16.65 13.57 133 1001438 13246 62474205
Intra-abdominal haematoma 16.62 13.57 4 1001567 1801 62485650
Rhonchi 16.62 13.57 10 1001561 2566 62484885
Pharyngeal operation 16.61 13.57 6 1001565 3 62487448
Staphylococcal skin infection 16.59 13.57 43 1001528 932 62486519
Hepatitis B reactivation 16.58 13.57 15 1001556 3122 62484329
Body temperature abnormal 16.56 13.57 70 1001501 1971 62485480
Vocal cord paralysis 16.51 13.57 7 1001564 2194 62485257
Product taste abnormal 16.45 13.57 6 1001565 2061 62485390
Hepatorenal syndrome 16.44 13.57 5 1001566 1927 62485524
Paradoxical drug reaction 16.42 13.57 25 1001546 4127 62483324
Spinal nerve stimulator implantation 16.41 13.57 15 1001556 120 62487331
Spinal laminectomy 16.38 13.57 36 1001535 699 62486752
Ejection fraction abnormal 16.35 13.57 4 1001567 1781 62485670
Cor pulmonale 16.28 13.57 6 1001565 2048 62485403
Spinal osteoarthritis 16.19 13.57 170 1001401 16016 62471435
Chorea 16.19 13.57 3 1001568 1621 62485830
Bite 16.15 13.57 28 1001543 453 62486998
Mucosal disorder 16.11 13.57 7 1001564 2162 62485289
False positive tuberculosis test 16.10 13.57 7 1001564 10 62487441
Bipolar I disorder 16.01 13.57 5 1001566 1894 62485557
Splenic infarction 16.00 13.57 4 1001567 1755 62485696
Tinea pedis 16.00 13.57 55 1001516 1401 62486050
Faeces hard 15.96 13.57 7 1001564 2150 62485301
Hypercalcaemia 15.91 13.57 333 1001238 27989 62459462
Abdominal adhesions 15.90 13.57 16 1001555 3166 62484285
Infected bunion 15.83 13.57 5 1001566 0 62487451
Smear cervix 15.83 13.57 5 1001566 0 62487451
Spinal meningioma benign 15.81 13.57 14 1001557 107 62487344
Intentional underdose 15.78 13.57 5 1001566 1877 62485574
Anion gap increased 15.78 13.57 5 1001566 1877 62485574
Red blood cell sedimentation rate decreased 15.78 13.57 18 1001553 192 62487259
Spinal fusion acquired 15.72 13.57 7 1001564 11 62487440
Urine leukocyte esterase positive 15.71 13.57 20 1001551 3559 62483892
Conjunctival hyperaemia 15.68 13.57 9 1001562 2370 62485081
Pelvic floor muscle weakness 15.68 13.57 11 1001560 57 62487394
Acinetobacter infection 15.62 13.57 3 1001568 1580 62485871
Cytomegalovirus colitis 15.60 13.57 9 1001562 2363 62485088
Diabetic neuropathy 15.55 13.57 24 1001547 3940 62483511
Enteritis infectious 15.55 13.57 7 1001564 2117 62485334
Varices oesophageal 15.54 13.57 16 1001555 3132 62484319
Extradural haematoma 15.50 13.57 4 1001567 1718 62485733
Pulse abnormal 15.50 13.57 9 1001562 2355 62485096
Metastases to spine 15.49 13.57 17 1001554 3232 62484219
Bacterial sepsis 15.49 13.57 24 1001547 3934 62483517
Bile duct stone 15.46 13.57 21 1001550 3635 62483816
Dry eye 15.45 13.57 789 1000782 39972 62447479
Mean platelet volume decreased 15.44 13.57 83 1001488 2586 62484865
Musculoskeletal injury 15.41 13.57 14 1001557 111 62487340
Incorrect dosage administered 15.40 13.57 69 1001502 1994 62485457
Therapy change 15.40 13.57 47 1001524 6034 62481417
Ligament operation 15.35 13.57 8 1001563 21 62487430
Hiccups 15.34 13.57 8 1001563 2223 62485228
Hair colour changes 15.32 13.57 16 1001555 3111 62484340
Psychotic symptom 15.31 13.57 3 1001568 1558 62485893
Oesophageal spasm 15.27 13.57 16 1001555 3107 62484344
Meniscus operation 15.24 13.57 15 1001556 133 62487318
Immunosuppression 15.22 13.57 209 1001362 8605 62478846
Dyspareunia 15.19 13.57 10 1001561 2445 62485006
Catarrh 15.14 13.57 3 1001568 1546 62485905
Tooth fracture 15.14 13.57 253 1001318 10857 62476594
Mole excision 15.10 13.57 16 1001555 156 62487295
Peptic ulcer haemorrhage 15.09 13.57 44 1001527 1024 62486427
Labelled drug-disease interaction medication error 15.07 13.57 15 1001556 135 62487316
Peripheral arterial occlusive disease 15.03 13.57 27 1001544 4174 62483277
Sinus pain 15.02 13.57 19 1001552 3391 62484060
Talipes 15.02 13.57 3 1001568 1537 62485914
Infected bite 15.02 13.57 68 1001503 1974 62485477
Device allergy 14.99 13.57 10 1001561 47 62487404
Apraxia 14.99 13.57 5 1001566 1816 62485635
Large intestinal obstruction 14.96 13.57 9 1001562 2310 62485141
Alcoholism 14.95 13.57 5 1001566 1813 62485638
Contraindication to medical treatment 14.94 13.57 33 1001538 643 62486808
Vascular pseudoaneurysm 14.94 13.57 3 1001568 1531 62485920
Asthmatic crisis 14.88 13.57 5 1001566 1808 62485643
Device alarm issue 14.88 13.57 3 1001568 1527 62485924
Lip ulceration 14.88 13.57 68 1001503 1982 62485469
Pruritus genital 14.87 13.57 12 1001559 2642 62484809
Kyphosis 14.85 13.57 11 1001560 2529 62484922
Eosinophil count decreased 14.85 13.57 8 1001563 2182 62485269
Expired product administered 14.79 13.57 49 1001522 6132 62481319
Mean cell haemoglobin concentration abnormal 14.76 13.57 14 1001557 118 62487333
Mallory-Weiss syndrome 14.76 13.57 3 1001568 1518 62485933
Diabetic eye disease 14.74 13.57 15 1001556 139 62487312
Intervertebral disc compression 14.72 13.57 47 1001524 1151 62486300
Anorectal discomfort 14.71 13.57 12 1001559 2627 62484824
Suicidal behaviour 14.71 13.57 12 1001559 2627 62484824
Anticonvulsant drug level increased 14.70 13.57 3 1001568 1514 62485937
Lymphadenopathy 14.70 13.57 745 1000826 37713 62449738
Mucosal erosion 14.69 13.57 3 1001568 1513 62485938
Melkersson-Rosenthal syndrome 14.69 13.57 7 1001564 14 62487437
Multiple injuries 14.69 13.57 5 1001566 1793 62485658
Meningitis staphylococcal 14.69 13.57 7 1001564 14 62487437
Skin fissures 14.68 13.57 257 1001314 11131 62476320
Liver abscess 14.67 13.57 14 1001557 2840 62484611
Blood creatinine decreased 14.66 13.57 42 1001529 5503 62481948
Upper respiratory tract inflammation 14.66 13.57 11 1001560 2512 62484939
Facial paralysis 14.65 13.57 146 1001425 13895 62473556
Product container issue 14.62 13.57 5 1001566 1788 62485663
Bladder disorder 14.61 13.57 82 1001489 8864 62478587
Skin candida 14.61 13.57 4 1001567 1651 62485800
Portal vein thrombosis 14.60 13.57 12 1001559 2618 62484833
Incorrect drug administration rate 14.60 13.57 25 1001546 3937 62483514
Skin swelling 14.54 13.57 99 1001472 3360 62484091
Abdominal abscess 14.54 13.57 31 1001540 4495 62482956
Butterfly rash 14.54 13.57 61 1001510 1712 62485739
Bladder repair 14.51 13.57 13 1001558 101 62487350
Gastrointestinal inflammation 14.48 13.57 43 1001528 5569 62481882
Streptococcal bacteraemia 14.41 13.57 5 1001566 1772 62485679
Colitis microscopic 14.36 13.57 217 1001354 9122 62478329
Salivary gland disorder 14.31 13.57 17 1001554 190 62487261
Hyporeflexia 14.26 13.57 6 1001565 1889 62485562
Injection site scab 14.23 13.57 25 1001546 409 62487042
Sternal fracture 14.19 13.57 9 1001562 2245 62485206
Strabismus 14.18 13.57 7 1001564 2007 62485444
In vitro fertilisation 14.14 13.57 12 1001559 86 62487365
Bone sequestrum 14.11 13.57 3 1001568 1471 62485980
Paronychia 14.10 13.57 43 1001528 5522 62481929
Muscle atrophy 14.07 13.57 60 1001511 6973 62480478
Hyperparathyroidism secondary 14.01 13.57 3 1001568 1464 62485987
Infected cyst 14.00 13.57 44 1001527 1068 62486383
Enterocolitis haemorrhagic 14 13.57 3 1001568 1463 62485988
Chronic disease 13.95 13.57 15 1001556 149 62487302
Ureteric obstruction 13.95 13.57 6 1001565 1864 62485587
Prescribed overdose 13.94 13.57 421 1001150 33732 62453719
Neck mass 13.91 13.57 101 1001470 3502 62483949
Multiple system atrophy 13.86 13.57 17 1001554 197 62487254
Recurrent cancer 13.85 13.57 7 1001564 1980 62485471
Suspected COVID-19 13.85 13.57 12 1001559 2550 62484901
Discontinued product administered 13.84 13.57 11 1001560 71 62487380
Premature rupture of membranes 13.81 13.57 37 1001534 4956 62482495
Linear IgA disease 13.79 13.57 3 1001568 1448 62486003
Extranodal marginal zone B-cell lymphoma (MALT type) 13.77 13.57 27 1001544 482 62486969
Upper-airway cough syndrome 13.77 13.57 255 1001316 11163 62476288
Paranasal sinus discomfort 13.76 13.57 117 1001454 4259 62483192
Temperature regulation disorder 13.74 13.57 50 1001521 6082 62481369
Skin disorder 13.73 13.57 583 1000988 28924 62458527
Lymphangiosis carcinomatosa 13.71 13.57 3 1001568 1442 62486009
BK virus infection 13.70 13.57 19 1001552 3260 62484191
Hepatitis E 13.70 13.57 3 1001568 1441 62486010
Gestational diabetes 13.69 13.57 77 1001494 8319 62479132
Peripheral vascular disorder 13.66 13.57 49 1001522 5986 62481465
Regurgitation 13.60 13.57 5 1001566 1709 62485742
Ileal stenosis 13.59 13.57 5 1001566 1708 62485743
Hypercoagulation 13.58 13.57 8 1001563 2077 62485374
Micturition disorder 13.58 13.57 12 1001559 2526 62484925
Dermatitis psoriasiform 13.58 13.57 71 1001500 2188 62485263
Application site vesicles 13.58 13.57 3 1001568 1432 62486019

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 11175.94 13.86 5390 231768 33615 34686158
Injection site erythema 7222.46 13.86 3036 234122 12863 34706910
Arthralgia 4779.52 13.86 5808 231350 164233 34555540
Drug ineffective 4663.87 13.86 9787 227371 446964 34272809
Injection site swelling 4336.56 13.86 1928 235230 9599 34710174
Injection site pruritus 3877.00 13.86 1541 235617 5442 34714331
Injection site reaction 3132.12 13.86 1602 235556 11431 34708342
Therapeutic product effect decreased 2846.33 13.86 2150 235008 32593 34687180
Injection site bruising 2802.93 13.86 1305 235853 7358 34712415
Joint swelling 2711.78 13.86 2637 234521 57253 34662520
Injection site haemorrhage 2620.93 13.86 1294 235864 8474 34711299
Wrong technique in product usage process 2618.83 13.86 2076 235082 33910 34685863
Therapeutic product effect incomplete 2478.36 13.86 2326 234832 48215 34671558
Nasopharyngitis 2470.01 13.86 2695 234463 67273 34652500
Pain in extremity 2261.50 13.86 3478 233680 123035 34596738
Pain 2173.01 13.86 4477 232681 200198 34519575
Accidental exposure to product 2009.00 13.86 1188 235970 11614 34708159
Product dose omission issue 1887.77 13.86 3109 234049 116602 34603171
Musculoskeletal stiffness 1777.83 13.86 1873 235285 44807 34674966
Injection site warmth 1696.27 13.86 607 236551 1455 34718318
Acute kidney injury 1481.93 13.86 170 236988 304818 34414955
Product storage error 1477.53 13.86 830 236328 7292 34712481
Device issue 1475.73 13.86 885 236273 8892 34710881
Injection site rash 1419.04 13.86 650 236508 3503 34716270
Mobility decreased 1330.59 13.86 1310 235848 28818 34690955
Toxicity to various agents 1171.48 13.86 43 237115 200319 34519454
Therapeutic response decreased 1170.54 13.86 1207 235951 28106 34691667
Psoriasis 1135.55 13.86 1358 235800 37454 34682319
Drug interaction 1129.50 13.86 113 237045 225833 34493940
Sinusitis 1084.33 13.86 1370 235788 40032 34679741
Joint stiffness 1043.27 13.86 741 236417 10132 34709641
Arthritis 1015.68 13.86 1156 236002 30190 34689583
Hypotension 956.06 13.86 175 236983 221474 34498299
Underdose 927.00 13.86 760 236398 13020 34706753
Anaemia 901.69 13.86 236 236922 233099 34486674
Treatment failure 901.37 13.86 1333 235825 45364 34674409
Musculoskeletal pain 895.01 13.86 1094 236064 30869 34688904
Arthropathy 893.25 13.86 1005 236153 25902 34693871
Psoriatic arthropathy 877.81 13.86 863 236295 18935 34700838
Skin plaque 789.18 13.86 453 236705 4161 34715612
Death 785.77 13.86 930 236228 397119 34322654
Febrile neutropenia 767.47 13.86 39 237119 136810 34582963
Synovitis 767.26 13.86 688 236470 13378 34706395
Injection site mass 728.27 13.86 491 236667 6135 34713638
Injection site discomfort 698.36 13.86 298 236860 1312 34718461
Knee arthroplasty 692.64 13.86 498 236660 6946 34712827
Swelling 677.29 13.86 1109 236049 41257 34678516
Injection site discolouration 666.36 13.86 282 236876 1211 34718562
Injection site urticaria 629.37 13.86 299 236859 1773 34718000
Thrombocytopenia 595.42 13.86 162 236996 156085 34563688
Injection site induration 593.72 13.86 319 236839 2541 34717232
Neutropenia 572.68 13.86 176 236982 156602 34563171
Completed suicide 569.85 13.86 22 237136 98146 34621627
Drug abuse 565.89 13.86 25 237133 99071 34620702
Diarrhoea 564.19 13.86 1124 236034 388788 34330985
Contraindicated product administered 554.35 13.86 706 236452 20775 34698998
Injection site extravasation 549.48 13.86 306 236852 2636 34717137
Malignant neoplasm progression 547.16 13.86 10 237148 88036 34631737
Confusional state 544.50 13.86 152 237006 144008 34575765
Peripheral swelling 515.41 13.86 1406 235752 75135 34644638
Vomiting 505.19 13.86 562 236596 247059 34472714
Dyspnoea 497.49 13.86 1143 236015 375639 34344134
Influenza 496.37 13.86 1063 236095 48603 34671170
Drug intolerance 484.43 13.86 1175 235983 58395 34661378
Hyponatraemia 471.63 13.86 21 237137 82670 34637103
Surgery 453.02 13.86 519 236639 13638 34706135
Dehydration 448.07 13.86 161 236997 129808 34589965
Constipation 434.12 13.86 193 236965 136789 34582984
Hyperkalaemia 426.59 13.86 9 237149 69380 34650393
Rhabdomyolysis 418.42 13.86 9 237149 68154 34651619
Bradycardia 399.91 13.86 29 237129 75389 34644384
Disease progression 395.02 13.86 121 237037 107956 34611817
C-reactive protein abnormal 393.99 13.86 384 236774 8326 34711447
Respiratory tract congestion 392.80 13.86 329 236829 5810 34713963
Decreased appetite 370.28 13.86 350 236808 166042 34553731
Therapy non-responder 369.56 13.86 819 236339 38327 34681446
Bone erosion 365.26 13.86 265 236893 3750 34716023
General physical health deterioration 362.59 13.86 210 236948 128059 34591714
Cardiac arrest 359.88 13.86 103 237055 96056 34623717
Hip arthroplasty 354.68 13.86 272 236886 4207 34715566
Respiratory failure 350.20 13.86 149 237009 108423 34611350
Headache 344.24 13.86 2434 234724 198201 34521572
Tachycardia 343.81 13.86 77 237081 84695 34635078
Back pain 343.58 13.86 1685 235473 120104 34599669
Injection site haematoma 342.50 13.86 189 236969 1596 34718177
Gastrointestinal haemorrhage 338.13 13.86 91 237067 88386 34631387
Hypokalaemia 321.65 13.86 18 237140 58196 34661577
Apparent death 319.01 13.86 235 236923 3409 34716364
Blood creatinine increased 314.93 13.86 125 237033 94851 34624922
Intentional product misuse 312.91 13.86 844 236314 44767 34675006
Abdominal pain 312.14 13.86 391 236767 163227 34556546
Seizure 308.84 13.86 163 236995 104694 34615079
Pancytopenia 304.60 13.86 132 237026 95025 34624748
Syncope 303.81 13.86 120 237038 91331 34628442
Iritis 302.66 13.86 162 236996 1279 34718494
Hypoglycaemia 301.56 13.86 17 237141 54623 34665150
Overdose 298.39 13.86 122 237036 90937 34628836
Hand deformity 294.49 13.86 226 236932 3499 34716274
Drug hypersensitivity 290.67 13.86 1199 235959 79330 34640443
Haemoglobin decreased 285.37 13.86 240 236918 120532 34599241
Platelet count decreased 285.22 13.86 236 236922 119481 34600292
Oropharyngeal pain 281.95 13.86 694 236464 34791 34684982
Neck pain 281.74 13.86 567 236591 24782 34694991
Disability 279.59 13.86 243 236915 4522 34715251
Unevaluable event 278.93 13.86 656 236502 31934 34687839
Cardio-respiratory arrest 274.59 13.86 28 237130 55245 34664528
Pyrexia 273.95 13.86 1246 235912 331767 34388006
Renal impairment 273.81 13.86 150 237008 94363 34625410
Infection 268.57 13.86 1275 235883 89640 34630133
Hypoxia 268.36 13.86 30 237128 55065 34664708
Incorrect dose administered by device 266.87 13.86 163 236995 1695 34718078
Atrial fibrillation 264.51 13.86 264 236894 122129 34597644
Diverticulitis 262.32 13.86 480 236678 19524 34700249
Electrocardiogram QT prolonged 261.40 13.86 3 237155 40949 34678824
International normalised ratio increased 260.32 13.86 15 237143 47312 34672461
Neutrophil count decreased 256.18 13.86 25 237133 51079 34668694
Intentional overdose 256.02 13.86 9 237149 43665 34676108
Agitation 254.13 13.86 42 237116 57357 34662416
Product use in unapproved indication 253.27 13.86 254 236904 117245 34602528
Tuberculin test positive 253.01 13.86 134 237024 1033 34718740
Metabolic acidosis 249.28 13.86 11 237147 43669 34676104
Condition aggravated 248.04 13.86 2184 234974 190012 34529761
Musculoskeletal disorder 241.17 13.86 252 236906 5952 34713821
Localised infection 235.67 13.86 426 236732 17161 34702612
Herpes zoster 235.34 13.86 636 236522 33763 34686010
Therapy interrupted 231.56 13.86 368 236790 13329 34706444
Red blood cell sedimentation rate increased 231.37 13.86 298 236860 8864 34710909
Hallucination 229.51 13.86 37 237121 51461 34668312
Red blood cell sedimentation rate abnormal 224.77 13.86 190 236968 3399 34716374
Rheumatoid arthritis 224.55 13.86 669 236489 37569 34682204
Grip strength decreased 224.04 13.86 180 236978 2989 34716784
Foot deformity 222.18 13.86 209 236949 4328 34715445
Inflammation 218.02 13.86 547 236611 27748 34692025
Somnolence 217.59 13.86 260 236898 110856 34608917
Injection site irritation 216.80 13.86 125 237033 1158 34718615
Cardiac failure 215.88 13.86 181 236977 91067 34628706
Joint lock 214.86 13.86 124 237034 1151 34718622
Rhinorrhoea 214.56 13.86 512 236646 25156 34694617
Osteoarthritis 214.37 13.86 449 236709 20193 34699580
Sepsis 213.48 13.86 512 236646 166049 34553724
Injection site vesicles 213.09 13.86 103 237055 638 34719135
Delirium 209.15 13.86 26 237132 43965 34675808
Suicide attempt 207.41 13.86 15 237143 39101 34680672
Hypersensitivity 207.09 13.86 892 236266 60143 34659630
Skin laceration 205.87 13.86 332 236826 12177 34707596
Joint range of motion decreased 205.65 13.86 251 236907 7061 34712712
Blood pressure decreased 202.46 13.86 50 237108 51465 34668308
Limb discomfort 202.37 13.86 308 236850 10739 34709034
Depressed level of consciousness 202.03 13.86 26 237132 42815 34676958
Nodule 201.46 13.86 240 236918 6579 34713194
Sinus congestion 200.77 13.86 218 236940 5387 34714386
Paranasal sinus hypersecretion 198.41 13.86 108 237050 885 34718888
Foetal exposure during pregnancy 198.10 13.86 16 237142 38085 34681688
Chondropathy 197.99 13.86 107 237051 863 34718910
Feeling abnormal 197.80 13.86 902 236256 62333 34657440
Multiple organ dysfunction syndrome 197.51 13.86 139 237019 76427 34643346
Coma 196.55 13.86 36 237122 45642 34674131
Septic shock 195.28 13.86 123 237035 71711 34648062
Lactic acidosis 194.40 13.86 10 237148 34762 34685011
Mental status changes 192.54 13.86 18 237140 38065 34681708
Melaena 192.19 13.86 12 237146 35368 34684405
Fall 191.44 13.86 719 236439 202166 34517607
Oxygen saturation decreased 186.41 13.86 66 237092 53752 34666021
Fear of injection 184.99 13.86 121 237037 1431 34718342
Pneumonia aspiration 184.72 13.86 31 237127 41872 34677901
Finger deformity 182.89 13.86 119 237039 1394 34718379
Plasma cell myeloma 181.16 13.86 33 237125 42004 34677769
Blood creatine phosphokinase increased 179.29 13.86 42 237116 44815 34674958
Hyperglycaemia 179.01 13.86 27 237131 39453 34680320
Injury associated with device 178.09 13.86 105 237053 1018 34718755
Injection site macule 176.61 13.86 47 237111 13 34719760
Upper respiratory tract infection 176.02 13.86 559 236599 32500 34687273
Sleep disorder due to general medical condition, insomnia type 175.19 13.86 110 237048 1206 34718567
Drug reaction with eosinophilia and systemic symptoms 174.05 13.86 13 237145 32999 34686774
Loss of consciousness 173.19 13.86 183 236975 82484 34637289
Uveitis 173.14 13.86 234 236924 7301 34712472
Aggression 171.37 13.86 29 237129 38935 34680838
Loss of personal independence in daily activities 171.18 13.86 555 236603 32624 34687149
Mycobacterium tuberculosis complex test positive 168.99 13.86 108 237050 1224 34718549
Sarcoidosis 168.87 13.86 147 237011 2741 34717032
Musculoskeletal discomfort 166.61 13.86 238 236920 7830 34711943
Device difficult to use 162.47 13.86 144 237014 2753 34717020
Spinal operation 162.45 13.86 145 237013 2799 34716974
Haematuria 162.44 13.86 68 237090 49998 34669775
Impaired work ability 161.96 13.86 217 236941 6713 34713060
Knee operation 160.90 13.86 125 237033 1972 34717801
Acute myocardial infarction 157.34 13.86 84 237074 53635 34666138
Asthenia 157.19 13.86 997 236161 244254 34475519
Lymphoma 155.05 13.86 293 236865 12214 34707559
Respiratory distress 153.67 13.86 28 237130 35637 34684136
Dysphagia 153.43 13.86 119 237039 62262 34657511
Spinal fusion surgery 152.89 13.86 92 237066 929 34718844
Infusion related reaction 152.43 13.86 85 237073 52972 34666801
Shoulder operation 152.11 13.86 95 237063 1031 34718742
Urinary retention 151.05 13.86 31 237127 36257 34683516
Unresponsive to stimuli 150.80 13.86 9 237149 27560 34692213
Orthostatic hypotension 149.64 13.86 6 237152 25913 34693860
Therapeutic product effect delayed 149.37 13.86 99 237059 1199 34718574
Impaired healing 149.36 13.86 325 236833 15009 34704764
Therapy cessation 148.83 13.86 345 236813 16628 34703145
Injection site recall reaction 148 13.86 37 237121 0 34719773
Iridocyclitis 147.91 13.86 108 237050 1544 34718229
Cardiac failure congestive 146.39 13.86 211 236947 83059 34636714
Cerebral haemorrhage 145.10 13.86 30 237128 34907 34684866
Blood bilirubin increased 145.07 13.86 40 237118 38256 34681517
Weight decreased 144.87 13.86 659 236499 175642 34544131
Mass 144.22 13.86 220 236938 7685 34712088
Ankylosing spondylitis 142.63 13.86 183 236975 5421 34714352
Ill-defined disorder 141.44 13.86 300 236858 13609 34706164
Neoplasm progression 139.42 13.86 4 237154 23296 34696477
Chronic kidney disease 138.55 13.86 53 237105 41157 34678616
Ascites 136.12 13.86 73 237085 46498 34673275
Cardiogenic shock 136.11 13.86 12 237146 26606 34693167
Hypoacusis 133.88 13.86 323 236835 15978 34703795
Haematemesis 132.64 13.86 16 237142 27695 34692078
Blood glucose increased 131.71 13.86 155 237003 66563 34653210
Drug dose omission by device 130.98 13.86 114 237044 2125 34717648
Agranulocytosis 129.61 13.86 8 237150 23813 34695960
Nausea 129.37 13.86 1581 235577 338327 34381446
Nasal congestion 129.30 13.86 397 236761 22660 34697113
Arthropod bite 129.19 13.86 125 237033 2684 34717089
Gait disturbance 129.05 13.86 1004 236154 84136 34635637
Joint noise 127.91 13.86 71 237087 607 34719166
Skin haemorrhage 127.38 13.86 158 237000 4520 34715253
Tooth infection 127.16 13.86 191 236967 6580 34713193
Encephalopathy 126.31 13.86 41 237117 35278 34684495
Haemorrhage 126.31 13.86 98 237060 51272 34668501
Bone marrow failure 125.96 13.86 23 237135 29230 34690543
Bronchitis 125.56 13.86 591 236567 41372 34678401
Joint effusion 125.03 13.86 165 236993 5028 34714745
Drug level increased 124.64 13.86 6 237152 22090 34697683
Blood pressure increased 123.20 13.86 258 236900 87844 34631929
Coronary artery disease 122.82 13.86 89 237069 48216 34671557
Pleural effusion 122.46 13.86 229 236929 81317 34638456
Blood urea increased 122.19 13.86 28 237130 30336 34689437
Toxic epidermal necrolysis 121.71 13.86 6 237152 21640 34698133
Mucosal inflammation 121.25 13.86 55 237103 38567 34681206
Joint destruction 121.21 13.86 57 237101 329 34719444
Sedation 120.80 13.86 5 237153 21001 34698772
Neuropathy peripheral 120.53 13.86 239 236919 83024 34636749
Hypervolaemia 119.36 13.86 3 237155 19706 34700067
Decreased immune responsiveness 118.66 13.86 95 237063 1569 34718204
Cholestasis 118.62 13.86 20 237138 26928 34692845
Sneezing 116.21 13.86 160 236998 5082 34714691
Pulmonary oedema 115.18 13.86 92 237066 47437 34672336
Renal failure 115.12 13.86 475 236683 130082 34589691
Haematocrit decreased 114.15 13.86 38 237120 32178 34687595
Adverse reaction 114.03 13.86 121 237037 2910 34716863
Hypocalcaemia 113.88 13.86 15 237143 24274 34695499
Shoulder arthroplasty 113.69 13.86 59 237099 434 34719339
Device malfunction 113.25 13.86 231 236927 10190 34709583
Dysarthria 113.21 13.86 47 237111 34735 34685038
Rash maculo-papular 112.97 13.86 27 237131 28424 34691349
Psychotic disorder 112.52 13.86 16 237142 24436 34695337
Inappropriate schedule of product administration 111.81 13.86 765 236393 61531 34658242
Urticaria 111.36 13.86 765 236393 61612 34658161
Furuncle 110.60 13.86 125 237033 3233 34716540
Sinus disorder 109.76 13.86 183 236975 6902 34712871
Adverse event 109.57 13.86 329 236829 18548 34701225
Heart rate increased 109.45 13.86 92 237066 46251 34673522
Abnormal behaviour 108.88 13.86 19 237139 24950 34694823
Suicidal ideation 108.57 13.86 70 237088 40318 34679455
Upper gastrointestinal haemorrhage 107.87 13.86 21 237137 25497 34694276
Oedema 107.79 13.86 91 237067 45650 34674123
Hepatic failure 107.12 13.86 50 237108 34481 34685292
Erythema 107.10 13.86 995 236163 87785 34631988
Hypoaesthesia 107.00 13.86 749 236409 60695 34659078
Pharyngitis streptococcal 106.07 13.86 110 237048 2574 34717199
Lymphocyte count decreased 105.99 13.86 14 237144 22608 34697165
Abdominal distension 105.98 13.86 145 237013 58347 34661426
Skin exfoliation 105.64 13.86 417 236741 27015 34692758
Ear infection 105.57 13.86 222 236936 10009 34709764
Joint arthroplasty 105.06 13.86 69 237089 822 34718951
Respiratory arrest 104.89 13.86 30 237128 28013 34691760
Rheumatoid factor negative 104.50 13.86 69 237089 830 34718943
Drug withdrawal syndrome 104.01 13.86 8 237150 19826 34699947
Pneumonitis 102.12 13.86 51 237107 33827 34685946
Leukopenia 102.08 13.86 168 236990 62688 34657085
Shock 101.99 13.86 20 237138 24159 34695614
Injection site injury 101.87 13.86 45 237113 219 34719554
Tumour lysis syndrome 101.80 13.86 3 237155 17056 34702717
Wheezing 101.76 13.86 79 237079 41323 34678450
Blood alkaline phosphatase increased 101.67 13.86 42 237116 31133 34688640
Foot operation 101.47 13.86 63 237095 676 34719097
Tooth fracture 101.20 13.86 125 237033 3560 34716213
Demyelination 101.18 13.86 117 237041 3104 34716669
COVID-19 101.10 13.86 236 236922 77314 34642459
Circumstance or information capable of leading to medication error 100.90 13.86 89 237069 1690 34718083
White blood cell count decreased 100.80 13.86 322 236836 95123 34624650
Ventricular tachycardia 100.22 13.86 28 237130 26551 34693222
Tubulointerstitial nephritis 98.53 13.86 13 237145 21011 34698762
Disorientation 98.49 13.86 51 237107 33137 34686636
Synovial cyst 97.95 13.86 99 237059 2245 34717528
Myelosuppression 97.65 13.86 9 237149 19256 34700517
Sinus headache 97.35 13.86 71 237087 1013 34718760
Ventricular fibrillation 96.80 13.86 19 237139 22935 34696838
Pancreatitis acute 96.59 13.86 35 237123 28106 34691667
Palmar-plantar erythrodysaesthesia syndrome 96.57 13.86 4 237154 16791 34702982
Angioedema 96.14 13.86 68 237090 37306 34682467
Dyspnoea exertional 96.11 13.86 91 237067 43188 34676585
Influenza like illness 96.07 13.86 407 236751 27227 34692546
Extra dose administered 95.93 13.86 127 237031 3882 34715891
Dizziness 95.73 13.86 984 236174 217537 34502236
Heart rate decreased 95.37 13.86 48 237110 31697 34688076
Diabetic ketoacidosis 95.34 13.86 7 237151 18025 34701748
Bone cyst 94.68 13.86 82 237076 1518 34718255
Tachypnoea 94.58 13.86 8 237150 18344 34701429
Eosinophilia 94.54 13.86 30 237128 26192 34693581
Injection site papule 93.85 13.86 46 237112 295 34719478
Blood lactate dehydrogenase increased 92.90 13.86 21 237137 22969 34696804
Cough 92.75 13.86 1482 235676 148658 34571115
Scratch 92.64 13.86 114 237044 3234 34716539
Altered state of consciousness 92.33 13.86 21 237137 22872 34696901
Contusion 91.71 13.86 488 236670 35876 34683897
Hallucination, visual 91.02 13.86 8 237150 17783 34701990
Anaphylactic reaction 90.97 13.86 53 237105 32248 34687525
Onychoclasis 90.12 13.86 86 237072 1814 34717959
Intentional product use issue 89.77 13.86 168 236990 59648 34660125
Arrhythmia 89.70 13.86 67 237091 35741 34684032
Circulatory collapse 89.59 13.86 17 237141 21021 34698752
Dyskinesia 89.52 13.86 21 237137 22392 34697381
Restlessness 88.64 13.86 31 237127 25451 34694322
Sinus tachycardia 88.29 13.86 8 237150 17352 34702421
Tuberculosis 87.21 13.86 185 236973 8392 34711381
Cognitive disorder 86.78 13.86 43 237115 28650 34691123
Anti-cyclic citrullinated peptide antibody positive 86.62 13.86 83 237075 1760 34718013
Chest pain 86.41 13.86 505 236653 126257 34593516
Jaundice 86.04 13.86 55 237103 31827 34687946
Subdural haematoma 85.91 13.86 17 237141 20404 34699369
Rheumatoid nodule 85.86 13.86 103 237055 2844 34716929
Gamma-glutamyltransferase increased 85.15 13.86 46 237112 29185 34690588
Enthesopathy 85.02 13.86 129 237029 4484 34715289
Haemoptysis 84.51 13.86 68 237090 34938 34684835
Sensitivity to weather change 83.66 13.86 77 237081 1549 34718224
Nail disorder 83.59 13.86 86 237072 1993 34717780
Malaise 83.15 13.86 1744 235414 184081 34535692
Dislocation of vertebra 83.09 13.86 46 237112 391 34719382
Exostosis 82.73 13.86 129 237029 4594 34715179
Generalised tonic-clonic seizure 82.30 13.86 21 237137 21153 34698620
Injection site inflammation 82.15 13.86 60 237098 858 34718915
Acne cystic 81.35 13.86 48 237110 466 34719307
Pneumonia 80.50 13.86 1861 235297 360766 34359007
Renal tubular necrosis 80.35 13.86 7 237151 15673 34704100
Myoclonus 79.94 13.86 5 237153 14720 34705053
Hyperbilirubinaemia 79.93 13.86 10 237148 16833 34702940
Acute respiratory failure 79.90 13.86 56 237102 30872 34688901
Drug eruption 79.47 13.86 306 236852 19592 34700181
Alanine aminotransferase abnormal 79.28 13.86 126 237032 4562 34715211
Pulmonary hypertension 78.97 13.86 22 237136 20902 34698871
Nerve compression 78.65 13.86 104 237054 3175 34716598
Acute respiratory distress syndrome 78.41 13.86 39 237119 25930 34693843
Leukocytosis 77.54 13.86 33 237125 24032 34695741
Device use error 77.52 13.86 88 237070 2287 34717486
Osteonecrosis of jaw 77.15 13.86 14 237144 17875 34701898
Aspartate aminotransferase increased 76.31 13.86 222 236936 67561 34652212
Atlantoaxial instability 75.88 13.86 40 237118 305 34719468
Tenderness 75.70 13.86 154 237004 6780 34712993
Rectal haemorrhage 74.70 13.86 98 237060 40151 34679622
Joint warmth 74.52 13.86 42 237116 371 34719402
Haemorrhage intracranial 74.39 13.86 10 237148 15936 34703837
Spinal instability 73.76 13.86 40 237118 325 34719448
Mineral metabolism disorder 73.05 13.86 40 237118 332 34719441
Injection site paraesthesia 72.92 13.86 30 237128 118 34719655
Chondrolysis 72.33 13.86 28 237130 90 34719683
Urinary tract infection 72.14 13.86 309 236849 83772 34636001
Joint fluid drainage 72.11 13.86 27 237131 77 34719696
Medication error 71.91 13.86 42 237116 25523 34694250
Cerebral infarction 71.87 13.86 49 237109 27406 34692367
Intentional self-injury 70.97 13.86 6 237152 13765 34706008
Accidental overdose 70.92 13.86 24 237134 20116 34699657
Tenosynovitis 70.73 13.86 118 237040 4452 34715321
Wrist deformity 70.60 13.86 39 237119 330 34719443
Joint ankylosis 70.51 13.86 69 237089 1503 34718270
Small intestinal obstruction 70.13 13.86 9 237149 14857 34704916
Pallor 70.07 13.86 43 237115 25437 34694336
Spinal pain 69.35 13.86 135 237023 5754 34714019
Status epilepticus 69.34 13.86 4 237154 12610 34707163
Treatment noncompliance 68.56 13.86 54 237104 28046 34691727
Intervertebral disc space narrowing 68.43 13.86 57 237101 998 34718775
Full blood count decreased 68.29 13.86 19 237139 18069 34701704
Neutropenic sepsis 68.28 13.86 7 237151 13760 34706013
Prostate cancer 68.22 13.86 482 236676 39167 34680606
Tremor 68.13 13.86 308 236850 82279 34637494
Palpitations 67.63 13.86 104 237054 39882 34679891
Skin discolouration 66.88 13.86 269 236889 17576 34702197
Hypophagia 66.82 13.86 40 237118 23982 34695791
Clostridium difficile colitis 66.37 13.86 13 237145 15717 34704056
Nephropathy toxic 66.23 13.86 5 237153 12583 34707190
Upper respiratory tract congestion 66.20 13.86 51 237107 794 34718979
Drug tolerance decreased 66.11 13.86 74 237084 1893 34717880
Rotator cuff repair 66.03 13.86 36 237122 296 34719477
Stevens-Johnson syndrome 66.00 13.86 22 237136 18617 34701156
Drug-induced liver injury 65.93 13.86 59 237099 28773 34691000
Coagulopathy 65.60 13.86 26 237132 19763 34700010
Urinary incontinence 65.58 13.86 23 237135 18851 34700922
Epilepsy 65.32 13.86 32 237126 21463 34698310
Corrective lens user 65.17 13.86 23 237135 52 34719721
Immune system disorder 64.85 13.86 121 237037 4994 34714779
Cyanosis 64.59 13.86 6 237152 12758 34707015
Pancreatitis 64.02 13.86 103 237055 38788 34680985
Fluid retention 63.94 13.86 53 237105 26834 34692939
COVID-19 pneumonia 63.73 13.86 18 237140 16949 34702824
Limb operation 63.47 13.86 48 237110 726 34719047
Intervertebral disc protrusion 63.02 13.86 179 236979 9777 34709996
Adrenal insufficiency 62.77 13.86 10 237148 14037 34705736
Disseminated intravascular coagulation 62.57 13.86 35 237123 21781 34697992
Hepatic encephalopathy 62.25 13.86 12 237146 14673 34705100
Fibromyalgia 61.88 13.86 90 237068 3010 34716763
Malignant melanoma 61.87 13.86 156 237002 7934 34711839
Tooth disorder 61.58 13.86 188 236970 10694 34709079
Blood sodium decreased 61.49 13.86 17 237141 16234 34703539
Latent tuberculosis 61.46 13.86 60 237098 1303 34718470
Troponin increased 61.43 13.86 4 237154 11385 34708388
Tooth extraction 61.39 13.86 113 237045 4615 34715158
Ileus 61.06 13.86 18 237140 16481 34703292
Oral surgery 60.80 13.86 42 237116 547 34719226
Acute hepatic failure 60.73 13.86 11 237147 14063 34705710
Intestinal obstruction 60.72 13.86 40 237118 22782 34696991
Electrolyte imbalance 60.62 13.86 12 237146 14400 34705373
Haematoma 60.24 13.86 51 237107 25554 34694219
Therapeutic response delayed 60.06 13.86 43 237115 595 34719178
No adverse event 59.90 13.86 41 237117 22886 34696887
Skin disorder 59.59 13.86 215 236943 13340 34706433
Endodontic procedure 59.28 13.86 37 237121 401 34719372
Skin ulcer 58.66 13.86 302 236856 21914 34697859
Joint injury 58.14 13.86 165 236993 9008 34710765
Red blood cell count decreased 58.01 13.86 67 237091 29023 34690750
Cytomegalovirus infection 57.96 13.86 55 237103 26080 34693693
Neutrophil count increased 57.71 13.86 22 237136 17124 34702649
Angina pectoris 57.55 13.86 77 237081 31286 34688487
Pruritus 57.54 13.86 1314 235844 140667 34579106
Rheumatoid factor increased 57.45 13.86 40 237118 528 34719245
Ischaemic stroke 57.26 13.86 26 237132 18224 34701549
Brain oedema 57.11 13.86 12 237146 13809 34705964
Hallucination, auditory 56.73 13.86 7 237151 11910 34707863
Aphasia 56.54 13.86 38 237120 21416 34698357
Increased tendency to bruise 56.48 13.86 100 237058 3961 34715812
Myocarditis 56.29 13.86 12 237146 13670 34706103
Anxiety 55.69 13.86 420 236738 99008 34620765
Throat irritation 55.41 13.86 178 236980 10407 34709366
Antibiotic therapy 55.32 13.86 21 237137 63 34719710
Hypothyroidism 55.12 13.86 37 237121 20865 34698908
Anuria 54.99 13.86 4 237154 10381 34709392
Terminal state 54.87 13.86 97 237061 3837 34715936
Physical disability 54.68 13.86 57 237101 1342 34718431
Hypothermia 54.53 13.86 5 237153 10743 34709030
Rheumatoid factor positive 54.14 13.86 42 237116 661 34719112
Blood potassium increased 54.14 13.86 22 237136 16473 34703300
Atrial flutter 54.08 13.86 19 237139 15555 34704218
Presyncope 54.05 13.86 31 237127 19028 34700745
Blood potassium decreased 53.94 13.86 27 237131 17888 34701885
Prescribed overdose 53.89 13.86 5 237153 10642 34709131
Hepatocellular injury 53.79 13.86 43 237115 22168 34697605
Pulmonary thrombosis 53.71 13.86 140 237018 7267 34712506
Meniscus injury 53.33 13.86 71 237087 2182 34717591
Muscle rigidity 53.08 13.86 5 237153 10513 34709260
Alanine aminotransferase increased 52.90 13.86 326 236832 80489 34639284
Myocardial ischaemia 52.77 13.86 26 237132 17382 34702391
Skin mass 52.70 13.86 96 237062 3889 34715884
Blood pressure systolic increased 52.44 13.86 47 237111 22905 34696868
Haemodynamic instability 52.41 13.86 3 237155 9520 34710253
Flushing 52.29 13.86 87 237071 32333 34687440
Pathogen resistance 52.14 13.86 3 237155 9479 34710294
Neck surgery 51.93 13.86 33 237125 370 34719403
Face oedema 51.91 13.86 8 237150 11508 34708265
Cardiac operation 51.84 13.86 83 237075 3024 34716749
Speech disorder 51.39 13.86 59 237099 25627 34694146
Gait inability 51.25 13.86 277 236881 20481 34699292
Anaphylactic shock 51.13 13.86 22 237136 15919 34703854
Gastric disorder 51.06 13.86 193 236965 12248 34707525
White blood cell count increased 50.63 13.86 129 237029 41022 34678751
Electrocardiogram abnormal 50.62 13.86 3 237155 9244 34710529
Malnutrition 50.57 13.86 12 237146 12697 34707076
Blood pressure fluctuation 50.51 13.86 58 237100 25191 34694582
Sudden death 50.34 13.86 20 237138 15181 34704592
Delusion 50.14 13.86 12 237146 12623 34707150
Renal injury 49.96 13.86 8 237150 11187 34708586
Cyst 49.94 13.86 101 237057 4427 34715346
Prostate infection 49.87 13.86 46 237112 928 34718845
Tooth loss 49.83 13.86 92 237066 3766 34716007
Acute coronary syndrome 49.72 13.86 15 237143 13530 34706243
Rotator cuff syndrome 49.70 13.86 115 237043 5534 34714239
Back disorder 49.56 13.86 127 237031 6524 34713249
Venous injury 48.85 13.86 29 237129 285 34719488
Shock haemorrhagic 48.72 13.86 9 237149 11345 34708428
Lymphopenia 48.61 13.86 25 237133 16310 34703463
Vein rupture 48.42 13.86 44 237114 870 34718903
Skin fissures 48.42 13.86 109 237049 5150 34714623
Ataxia 47.93 13.86 17 237141 13836 34705937
Urine output decreased 47.60 13.86 6 237152 10043 34709730
Lyme disease 47.49 13.86 46 237112 989 34718784
Burning sensation 47.15 13.86 248 236910 18146 34701627
Bronchospasm 47.15 13.86 8 237150 10723 34709050
Pustular psoriasis 47.12 13.86 57 237101 1588 34718185
Cardiomegaly 46.88 13.86 23 237135 15415 34704358
Transplant rejection 46.85 13.86 7 237151 10304 34709469
Subarachnoid haemorrhage 46.36 13.86 14 237144 12621 34707152
Haematochezia 46.34 13.86 161 236997 46373 34673400
Alopecia 46.01 13.86 303 236855 24052 34695721
Irritability 45.93 13.86 60 237098 24630 34695143
Tricuspid valve incompetence 45.82 13.86 6 237152 9754 34710019
Cerebrovascular accident 45.73 13.86 362 236796 84449 34635324
Acne 45.68 13.86 172 236986 10894 34708879
Transient ischaemic attack 45.56 13.86 73 237085 27540 34692233
Atrioventricular block complete 45.54 13.86 5 237153 9314 34710459
Nephrolithiasis 45.50 13.86 357 236801 29976 34689797
Full blood count abnormal 45.38 13.86 36 237122 18632 34701141
Post procedural infection 45.10 13.86 101 237057 4755 34715018
Hepatic cytolysis 44.94 13.86 21 237137 14475 34705298
Rash pruritic 44.88 13.86 325 236833 26616 34693157
Ankle deformity 44.82 13.86 25 237133 216 34719557
Right ventricular failure 44.80 13.86 4 237154 8780 34710993
Cytology abnormal 44.73 13.86 30 237128 371 34719402
Scab 44.58 13.86 98 237060 4556 34715217
Drug specific antibody present 44.54 13.86 80 237078 3205 34716568
Pulmonary arterial hypertension 44.51 13.86 4 237154 8735 34711038
Mania 44.28 13.86 6 237152 9505 34710268
Mitral valve incompetence 44.27 13.86 23 237135 14920 34704853
Clostridium difficile infection 44.02 13.86 38 237120 18860 34700913
Aspiration 43.87 13.86 14 237144 12180 34707593
Tooth abscess 43.86 13.86 112 237046 5741 34714032
Urosepsis 43.78 13.86 16 237142 12783 34706990
Haemodialysis 43.78 13.86 9 237149 10517 34709256
Rash erythematous 43.75 13.86 305 236853 24672 34695101
Lipase increased 43.70 13.86 6 237152 9410 34710363
Neoplasm malignant 43.45 13.86 257 236901 19648 34700125
Product prescribing error 43.39 13.86 55 237103 22872 34696901
Hepatotoxicity 43.36 13.86 49 237109 21436 34698337
Atelectasis 43.33 13.86 34 237124 17693 34702080
Chronic obstructive pulmonary disease 43.04 13.86 178 236980 48740 34671033
Intestinal sepsis 43.00 13.86 36 237122 635 34719138
Balance disorder 42.99 13.86 137 237021 40517 34679256
C-reactive protein increased 42.87 13.86 558 236600 53540 34666233
Nightmare 42.86 13.86 22 237136 14369 34705404
Obstructive airways disorder 42.81 13.86 26 237132 15468 34704305
Dental implantation 42.73 13.86 17 237141 60 34719713
Skin injury 42.40 13.86 65 237093 2280 34717493
Thrombotic microangiopathy 42.37 13.86 10 237148 10620 34709153
Oliguria 42.24 13.86 4 237154 8376 34711397
Myopathy 42.04 13.86 13 237145 11541 34708232
Elbow operation 42.03 13.86 20 237138 119 34719654
Hypoalbuminaemia 42.01 13.86 15 237143 12159 34707614
Staphylococcal infection 41.91 13.86 372 236786 32388 34687385
Activated partial thromboplastin time prolonged 41.66 13.86 5 237153 8690 34711083
Feeling hot 41.57 13.86 249 236909 19123 34700650
Oesophagitis 41.43 13.86 19 237139 13242 34706531
Paranoia 41.43 13.86 15 237143 12053 34707720
Prothrombin time prolonged 41.35 13.86 7 237151 9399 34710374
Muscle spasms 41.33 13.86 727 236431 74274 34645499
Injection site nodule 41.33 13.86 54 237104 1629 34718144
Basal cell carcinoma 41.12 13.86 251 236907 19407 34700366
Ankle operation 41.03 13.86 24 237134 229 34719544
Chills 40.93 13.86 352 236806 80691 34639082
Arthrodesis 40.90 13.86 30 237128 432 34719341
Bacteraemia 40.86 13.86 44 237114 19673 34700100
Incorrect disposal of product 40.80 13.86 27 237131 326 34719447
Prescribed underdose 40.74 13.86 6 237152 8927 34710846
Left ventricular dysfunction 40.71 13.86 9 237149 9998 34709775
Rash macular 40.70 13.86 184 236974 12658 34707115
Duodenal ulcer 40.63 13.86 10 237148 10322 34709451
Toe operation 40.49 13.86 14 237144 29 34719744
Eye operation 40.38 13.86 28 237130 367 34719406
Device failure 40.37 13.86 64 237094 2312 34717461
Substance abuse 40.30 13.86 3 237155 7638 34712135
Cytopenia 40.11 13.86 18 237140 12705 34707068
Hyperthyroidism 40.07 13.86 11 237147 10555 34709218
Product quality issue 39.99 13.86 34 237124 17001 34702772
Sacroiliitis 39.83 13.86 50 237108 1448 34718325
Paranasal sinus discomfort 39.80 13.86 38 237120 802 34718971
Viral upper respiratory tract infection 39.62 13.86 69 237089 2697 34717076
Hernia repair 39.61 13.86 46 237112 1226 34718547
Hepatitis cholestatic 39.52 13.86 4 237154 7943 34711830
Rash papular 39.36 13.86 156 237002 10122 34709651
Proteinuria 39.30 13.86 41 237117 18601 34701172
Blood calcium decreased 39.19 13.86 10 237148 10074 34709699
Cardiac failure chronic 39.09 13.86 4 237154 7875 34711898
Failure to thrive 38.71 13.86 6 237152 8595 34711178
Nail pitting 38.62 13.86 25 237133 290 34719483
Hepatic enzyme increased 38.40 13.86 420 236738 38660 34681113
Glomerular filtration rate decreased 38.32 13.86 20 237138 12941 34706832
Klebsiella infection 38.28 13.86 6 237152 8525 34711248
Pulmonary sarcoidosis 38.24 13.86 32 237126 564 34719209
Lung neoplasm malignant 38.23 13.86 225 236933 17170 34702603
Blood phosphorus increased 38.10 13.86 4 237154 7717 34712056
Spondylitis 37.78 13.86 45 237113 1233 34718540
Hyperuricaemia 37.62 13.86 5 237153 8038 34711735
Hip surgery 37.35 13.86 42 237116 1080 34718693
Hypertension 37.32 13.86 676 236482 135767 34584006
Anhedonia 37.25 13.86 4 237154 7581 34712192
Body temperature decreased 37.25 13.86 21 237137 13013 34706760
Disturbance in attention 37.06 13.86 75 237083 25870 34693903
Gastritis 36.87 13.86 57 237101 21816 34697957
Dental operation 36.86 13.86 27 237131 388 34719385
Purpura 36.81 13.86 12 237146 10299 34709474
Hypovolaemic shock 36.75 13.86 3 237155 7082 34712691
Second primary malignancy 36.66 13.86 5 237153 7881 34711892
Osteosclerosis 36.50 13.86 45 237113 1279 34718494
Intestinal ischaemia 36.09 13.86 5 237153 7789 34711984
Hepatitis 35.97 13.86 67 237091 23837 34695936
Hepatic enzyme abnormal 35.77 13.86 66 237092 2700 34717073
Injection site hypersensitivity 35.57 13.86 24 237134 300 34719473
Acute myeloid leukaemia 35.44 13.86 43 237115 18227 34701546
Neck mass 35.40 13.86 49 237109 1564 34718209
Gallbladder operation 35.33 13.86 29 237129 497 34719276
Device related infection 35.13 13.86 39 237119 17198 34702575
Intestinal polyp 34.92 13.86 39 237119 995 34718778
Hyperthermia 34.89 13.86 14 237144 10563 34709210
Acute generalised exanthematous pustulosis 34.79 13.86 3 237155 6773 34713000
Guttate psoriasis 34.52 13.86 22 237136 248 34719525
Toxic skin eruption 34.51 13.86 17 237141 11368 34708405
Respiratory rate increased 34.47 13.86 12 237146 9882 34709891
Exposure during pregnancy 34.45 13.86 9 237149 8925 34710848
Angina unstable 34.43 13.86 18 237140 11635 34708138
Arteriosclerosis coronary artery 34.42 13.86 21 237137 12464 34707309
Bundle branch block right 34.38 13.86 5 237153 7511 34712262
Polyuria 34.30 13.86 8 237150 8566 34711207
Withdrawal syndrome 34.27 13.86 21 237137 12434 34707339
Injection site coldness 34.23 13.86 11 237147 16 34719757
Discomfort 34.20 13.86 233 236925 18705 34701068
End stage renal disease 34.03 13.86 9 237149 8852 34710921
Toothache 33.96 13.86 108 237050 6280 34713493
Oedema peripheral 33.90 13.86 590 236568 119222 34600551
Hypercalcaemia 33.77 13.86 33 237125 15435 34704338
Parkinsonism 33.76 13.86 7 237151 8131 34711642
Progressive multifocal leukoencephalopathy 33.75 13.86 12 237146 9752 34710021
Polychondritis 33.54 13.86 21 237137 229 34719544
Bronchopulmonary aspergillosis 33.51 13.86 30 237128 14629 34705144
Hypogammaglobulinaemia 33.50 13.86 6 237152 7734 34712039
Myelodysplastic syndrome 33.40 13.86 49 237109 19159 34700614
Haemorrhagic stroke 33.29 13.86 3 237155 6536 34713237
Gastric haemorrhage 33.17 13.86 14 237144 10247 34709526
Pericardial effusion 32.96 13.86 74 237084 24588 34695185
Emotional distress 32.87 13.86 32 237126 14994 34704779
Nail psoriasis 32.86 13.86 15 237143 80 34719693
Rheumatoid lung 32.62 13.86 36 237122 906 34718867
Pulmonary fibrosis 32.43 13.86 225 236933 18171 34701602
Hiccups 32.20 13.86 14 237144 10068 34709705
Nail bed disorder 32.20 13.86 10 237148 12 34719761
Meniscus operation 32.20 13.86 10 237148 12 34719761
Injection site hypoaesthesia 32.12 13.86 15 237143 85 34719688
Polyarthritis 32.09 13.86 85 237073 4455 34715318
Eye disorder 32.08 13.86 139 237019 9389 34710384
Candida infection 31.98 13.86 44 237114 17671 34702102
Pulmonary haemorrhage 31.83 13.86 15 237143 10289 34709484
Blood pressure diastolic decreased 31.73 13.86 11 237147 9083 34710690
Left ventricular hypertrophy 31.72 13.86 8 237150 8122 34711651
Macule 31.68 13.86 45 237113 1472 34718301
Oral herpes 31.54 13.86 96 237062 5451 34714322
Apnoea 31.51 13.86 4 237154 6660 34713113
Ependymoma malignant 31.34 13.86 10 237148 14 34719759
Nocturia 31.33 13.86 15 237143 10195 34709578
Gastroenteritis viral 31.31 13.86 113 237045 7011 34712762
Pseudomonas infection 31.22 13.86 23 237135 12359 34707414
Lupus-like syndrome 31.02 13.86 62 237096 2694 34717079
Cataract operation 31.02 13.86 41 237117 1251 34718522
Appendicitis 30.73 13.86 33 237125 14774 34704999
Insurance issue 30.69 13.86 52 237106 1987 34717786
Transfusion 30.63 13.86 10 237148 8575 34711198
Arthritis bacterial 30.58 13.86 90 237068 5016 34714757
Artificial crown procedure 30.55 13.86 10 237148 16 34719757
Hydronephrosis 30.54 13.86 16 237142 10330 34709443
Product use issue 30.40 13.86 278 236880 62938 34656835
Limb deformity 30.39 13.86 28 237130 564 34719209
Squamous cell carcinoma 30.29 13.86 156 237002 11319 34708454
Asphyxia 30.24 13.86 5 237153 6830 34712943
Blood loss anaemia 30.21 13.86 9 237149 8185 34711588
Carpal tunnel syndrome 29.94 13.86 85 237073 4641 34715132
Accident at work 29.75 13.86 32 237126 782 34718991
Psychomotor hyperactivity 29.73 13.86 14 237144 9608 34710165
Arthritis infective 29.42 13.86 69 237089 3350 34716423
Atrial septal defect 29.37 13.86 7 237151 7385 34712388
Ingrown hair 29.08 13.86 17 237141 162 34719611
Coordination abnormal 28.91 13.86 8 237150 7636 34712137
Rocky mountain spotted fever 28.89 13.86 9 237149 11 34719762
Arthropod sting 28.87 13.86 26 237132 508 34719265
Ear congestion 28.86 13.86 27 237131 555 34719218
Body temperature increased 28.57 13.86 46 237112 17322 34702451
Low birth weight baby 28.57 13.86 9 237149 7896 34711877
Drug dependence 28.20 13.86 78 237080 24139 34695634
Limb crushing injury 28.16 13.86 14 237144 93 34719680
Ventricular extrasystoles 28.14 13.86 24 237134 11984 34707789
Peritonitis bacterial 28.10 13.86 4 237154 6106 34713667
Stent placement 28.05 13.86 87 237071 4991 34714782
Lower respiratory tract infection 27.92 13.86 333 236825 31304 34688469
Gastroenteritis 27.82 13.86 34 237124 14366 34705407
Heart rate irregular 27.80 13.86 40 237118 15767 34704006
Weight increased 27.65 13.86 454 236704 92579 34627194
Osteolysis 27.60 13.86 64 237094 3084 34716689
Breast feeding 27.56 13.86 8 237150 6 34719767
Hyperlipidaemia 27.34 13.86 35 237123 14494 34705279
Viral infection 27.31 13.86 209 236949 17414 34702359
Medical device implantation 27.19 13.86 27 237131 599 34719174
Petechiae 27.16 13.86 15 237143 9403 34710370
Obsessive-compulsive disorder 27.15 13.86 3 237155 5561 34714212
Ventricular hypokinesia 27.08 13.86 3 237155 5549 34714224
Increased upper airway secretion 27.03 13.86 46 237112 1764 34718009
Gastritis erosive 27.01 13.86 4 237154 5928 34713845
Hepatitis acute 26.86 13.86 9 237149 7592 34712181
Lethargy 26.83 13.86 166 236992 40956 34678817
Haemophagocytic lymphohistiocytosis 26.83 13.86 29 237129 12944 34706829
Liver injury 26.81 13.86 37 237121 14841 34704932
Transaminases increased 26.56 13.86 93 237065 26730 34693043
Hypotonia 26.55 13.86 10 237148 7843 34711930
Anal incontinence 26.53 13.86 10 237148 7839 34711934
Device occlusion 26.40 13.86 6 237152 6539 34713234
Head injury 26.36 13.86 52 237106 18108 34701665
Supraventricular tachycardia 26.32 13.86 22 237136 11095 34708678
Impaired quality of life 26.32 13.86 4 237154 5814 34713959
Cholangitis 26.30 13.86 13 237145 8676 34711097
Hepatitis B virus test positive 26.20 13.86 20 237138 307 34719466
Cardiac failure acute 26.18 13.86 20 237138 10550 34709223
Trigger finger 26.18 13.86 31 237127 844 34718929
Aplasia pure red cell 26.01 13.86 5 237153 6127 34713646
Adverse drug reaction 25.96 13.86 309 236849 29033 34690740
Stomatitis 25.93 13.86 419 236739 42095 34677678
Colitis 25.89 13.86 150 237008 37600 34682173
Intervertebral disc operation 25.83 13.86 18 237140 238 34719535
Dermatitis atopic 25.80 13.86 3 237155 5344 34714429
Hemiparesis 25.76 13.86 42 237116 15736 34704037
Wrong product administered 25.72 13.86 3 237155 5331 34714442
Chest discomfort 25.70 13.86 241 236917 54289 34665484
Prostatic operation 25.64 13.86 22 237136 402 34719371
Episcleritis 25.59 13.86 16 237142 174 34719599
Gynaecomastia 25.55 13.86 19 237139 10161 34709612
Amyotrophic lateral sclerosis 25.52 13.86 33 237125 985 34718788
Peritonitis 25.40 13.86 45 237113 16320 34703453
Cardiomyopathy 25.38 13.86 47 237111 16761 34703012
Infected bite 25.37 13.86 22 237136 408 34719365
Dental caries 25.29 13.86 78 237080 4461 34715312
Chromaturia 25.29 13.86 37 237121 14483 34705290
Meningitis viral 25.28 13.86 31 237127 876 34718897
Glycosylated haemoglobin increased 25.08 13.86 24 237134 11336 34708437
Rubber sensitivity 25.03 13.86 17 237141 215 34719558
Hypertransaminasaemia 25.03 13.86 4 237154 5602 34714171
Systemic infection 24.96 13.86 3 237155 5209 34714564
Onychomadesis 24.94 13.86 25 237133 561 34719212
Drug resistance 24.94 13.86 91 237067 25836 34693937
Asthma 24.91 13.86 178 236980 42478 34677295
Hospice care 24.91 13.86 8 237150 6932 34712841
Food intolerance 24.88 13.86 39 237119 1395 34718378
Pemphigoid 24.71 13.86 14 237144 8652 34711121
Dermatitis contact 24.67 13.86 66 237092 3480 34716293
Decubitus ulcer 24.60 13.86 15 237143 8906 34710867
Liver function test increased 24.42 13.86 176 236982 14389 34705384
Carpal tunnel decompression 24.38 13.86 17 237141 225 34719548
Dysuria 24.38 13.86 98 237060 27054 34692719
Road traffic accident 24.33 13.86 202 236956 17248 34702525
Injection site hyperaesthesia 24.26 13.86 7 237151 5 34719768
Benign prostatic hyperplasia 24.22 13.86 38 237120 14457 34705316
Tendon sheath incision 24 13.86 6 237152 0 34719773
Depression 23.80 13.86 490 236668 96608 34623165
Blood magnesium decreased 23.78 13.86 7 237151 6416 34713357
Iron deficiency anaemia 23.77 13.86 21 237137 10308 34709465
Ageusia 23.67 13.86 21 237137 10287 34709486
Arteriosclerosis 23.39 13.86 28 237130 11940 34707833
Dialysis 23.24 13.86 25 237133 11183 34708590
Ligament operation 23.20 13.86 7 237151 7 34719766
Haemolysis 23.19 13.86 13 237145 8081 34711692
Exposure to communicable disease 23.13 13.86 14 237144 143 34719630
Muscle swelling 23.10 13.86 20 237138 370 34719403
Bundle branch block left 23.10 13.86 6 237152 5973 34713800
Euphoric mood 23.10 13.86 5 237153 5636 34714137
Ligament rupture 23.08 13.86 32 237126 1023 34718750
Herpes ophthalmic 23.06 13.86 24 237134 564 34719209
Premature baby 23.04 13.86 63 237095 19570 34700203
Amylase increased 23.04 13.86 6 237152 5962 34713811
Cutaneous sarcoidosis 22.97 13.86 14 237144 145 34719628
Toxic encephalopathy 22.87 13.86 4 237154 5245 34714528
Device dislocation 22.79 13.86 7 237151 6242 34713531
Blood glucose decreased 22.79 13.86 34 237124 13203 34706570
Tonsil cancer 22.66 13.86 33 237125 1105 34718668
Intervertebral disc disorder 22.59 13.86 44 237114 1876 34717897
Product complaint 22.59 13.86 6 237152 5884 34713889
Graft versus host disease 22.56 13.86 23 237135 10546 34709227
Colitis ischaemic 22.31 13.86 8 237150 6467 34713306
Intentional dose omission 22.22 13.86 63 237095 3437 34716336
Acute pulmonary oedema 22.21 13.86 11 237147 7332 34712441
Ankle fracture 22.17 13.86 70 237088 4055 34715718
Hyperaesthesia teeth 22.15 13.86 23 237135 539 34719234
Aplastic anaemia 22.07 13.86 20 237138 9696 34710077
Gastric ulcer haemorrhage 22.07 13.86 5 237153 5461 34714312
Lower gastrointestinal haemorrhage 22.02 13.86 19 237139 9433 34710340
Retinal haemorrhage 21.91 13.86 4 237154 5085 34714688
Frequent bowel movements 21.86 13.86 33 237125 12754 34707019
Respiratory syncytial virus infection 21.85 13.86 3 237155 4706 34715067
Diabetes mellitus inadequate control 21.83 13.86 36 237122 13428 34706345
Ischaemic cardiomyopathy 21.83 13.86 8 237150 6381 34713392
Embolism 21.82 13.86 13 237145 7816 34711957
Memory impairment 21.79 13.86 414 236744 42904 34676869
Sunburn 21.72 13.86 42 237116 1781 34717992
Atrioventricular block 21.63 13.86 14 237144 8049 34711724
Erectile dysfunction 21.49 13.86 70 237088 20567 34699206
Cachexia 21.38 13.86 11 237147 7175 34712598
Walking aid user 21.32 13.86 43 237115 1881 34717892
Cerebral haematoma 21.28 13.86 3 237155 4612 34715161
Ventricular hypertrophy 21.23 13.86 3 237155 4604 34715169
Limb injury 21.21 13.86 144 237014 11545 34708228
Ischaemia 21.06 13.86 3 237155 4577 34715196
International normalised ratio decreased 20.98 13.86 3 237155 4564 34715209
False positive tuberculosis test 20.96 13.86 6 237152 4 34719769
Paraesthesia 20.93 13.86 577 236581 63595 34656178
Haemorrhoids 20.93 13.86 42 237116 14533 34705240
Ecchymosis 20.86 13.86 10 237148 6793 34712980
Frustration tolerance decreased 20.84 13.86 51 237107 2545 34717228
Acute graft versus host disease 20.81 13.86 9 237149 6494 34713279
Myositis 20.78 13.86 31 237127 12039 34707734
Propionibacterium infection 20.72 13.86 16 237142 250 34719523
Limb mass 20.54 13.86 25 237133 701 34719072
Rales 20.54 13.86 22 237136 9861 34709912
Incontinence 20.53 13.86 7 237151 5840 34713933
Cartilage injury 20.50 13.86 22 237136 536 34719237
Seronegative arthritis 20.50 13.86 30 237128 1009 34718764
Tendon disorder 20.50 13.86 54 237104 2821 34716952
Brain injury 20.47 13.86 8 237150 6134 34713639
Lung infiltration 20.47 13.86 35 237123 12870 34706903
Wrist surgery 20.44 13.86 13 237145 146 34719627
Tongue disorder 20.41 13.86 81 237077 5258 34714515
Injection site anaesthesia 20.40 13.86 7 237151 14 34719759
Thyroid cancer 20.38 13.86 39 237119 1641 34718132
Red cell distribution width increased 20.37 13.86 8 237150 6115 34713658
Obesity 20.36 13.86 35 237123 12843 34706930
Pulse absent 20.28 13.86 7 237151 5796 34713977
Eosinophil count increased 20.25 13.86 17 237141 8555 34711218
Lymphadenopathy 20.25 13.86 288 236870 28175 34691598
Skin lesion 20.19 13.86 233 236925 21728 34698045
Bradyphrenia 20.17 13.86 4 237154 4794 34714979
Injection site laceration 20.16 13.86 8 237150 28 34719745
Post procedural haemorrhage 20.13 13.86 16 237142 8273 34711500
Gastrointestinal disorder 20.11 13.86 333 236825 33615 34686158
Protein total decreased 20.10 13.86 5 237153 5125 34714648
Pulseless electrical activity 20.06 13.86 12 237146 7199 34712574
Hangnail 20 13.86 5 237153 0 34719773
Tuberculin test 20 13.86 5 237153 0 34719773
Bunion operation 20 13.86 5 237153 0 34719773
Flatulence 20.00 13.86 75 237083 21123 34698650
Haemolytic anaemia 19.97 13.86 25 237133 10454 34709319
Partial seizures 19.94 13.86 4 237154 4756 34715017
Systemic lupus erythematosus rash 19.92 13.86 10 237148 68 34719705
Pathological fracture 19.91 13.86 3 237155 4388 34715385
Tooth impacted 19.80 13.86 10 237148 69 34719704
Taste disorder 19.77 13.86 12 237146 7143 34712630
Occupational exposure to product 19.76 13.86 18 237140 357 34719416
Complication associated with device 19.73 13.86 8 237150 5998 34713775
Prostatic specific antigen increased 19.66 13.86 44 237114 14636 34705137
Fine motor skill dysfunction 19.64 13.86 40 237118 1762 34718011
General symptom 19.62 13.86 27 237131 857 34718916
Faeces discoloured 19.59 13.86 45 237113 14833 34704940
Interstitial lung disease 19.58 13.86 318 236840 64964 34654809
Foetal heart rate decreased 19.56 13.86 9 237149 49 34719724
Device defective 19.47 13.86 25 237133 741 34719032
Rheumatoid factor 19.45 13.86 10 237148 72 34719701
Nail bed bleeding 19.44 13.86 18 237140 365 34719408
Immune thrombocytopenia 19.44 13.86 20 237138 9132 34710641
Duodenal ulcer haemorrhage 19.43 13.86 5 237153 5008 34714765
Metastases to bone 19.41 13.86 32 237126 11938 34707835
Mouth haemorrhage 19.32 13.86 6 237152 5313 34714460
Tendonitis 19.30 13.86 117 237041 9023 34710750
Nephropathy 19.24 13.86 8 237150 5909 34713864
Cervical vertebral fracture 19.18 13.86 42 237116 1947 34717826
Cardiovascular disorder 19.15 13.86 24 237134 10032 34709741
Fibrin D dimer increased 19.01 13.86 3 237155 4241 34715532
Immunosuppression 19.00 13.86 89 237069 6215 34713558
Cyst removal 18.96 13.86 8 237150 34 34719739
Systemic lupus erythematosus 18.93 13.86 62 237096 3662 34716111
Pulmonary alveolar haemorrhage 18.88 13.86 14 237144 7498 34712275
Dysgeusia 18.86 13.86 104 237054 26393 34693380
Device dispensing error 18.85 13.86 9 237149 54 34719719
Bladder transitional cell carcinoma recurrent 18.63 13.86 12 237146 138 34719635
Animal bite 18.61 13.86 22 237136 598 34719175
Swollen tongue 18.57 13.86 45 237113 14560 34705213
Weight fluctuation 18.57 13.86 6 237152 5179 34714594
Pulmonary embolism 18.56 13.86 465 236693 89281 34630492
Whipple's disease 18.56 13.86 6 237152 9 34719764
Poor venous access 18.56 13.86 6 237152 5177 34714596
Nail infection 18.53 13.86 16 237142 295 34719478
Myocardial infarction 18.43 13.86 654 236504 120431 34599342
Cerebral ischaemia 18.33 13.86 10 237148 6312 34713461
Spinal disorder 18.31 13.86 67 237091 4185 34715588
Blood uric acid increased 18.30 13.86 23 237135 9601 34710172
Tendon operation 18.26 13.86 8 237150 38 34719735
Secretion discharge 18.26 13.86 84 237074 5821 34713952
Proctalgia 18.19 13.86 8 237150 5715 34714058
Injection site pustule 18.18 13.86 6 237152 10 34719763
Oral candidiasis 18.17 13.86 34 237124 12076 34707697
Blood culture positive 18.10 13.86 5 237153 4778 34714995
Product administration error 18.04 13.86 54 237104 16290 34703483
Iron deficiency 17.95 13.86 7 237151 5374 34714399
Malignant melanoma stage I 17.87 13.86 10 237148 87 34719686
Head discomfort 17.85 13.86 65 237093 4051 34715722
Lung consolidation 17.79 13.86 9 237149 5927 34713846
Pneumocystis jirovecii pneumonia 17.78 13.86 71 237087 19639 34700134
Neonatal respiratory distress syndrome 17.74 13.86 3 237155 4031 34715742
Mononucleosis syndrome 17.71 13.86 9 237149 63 34719710
Joint surgery 17.67 13.86 5 237153 3 34719770
Erythrodermic psoriasis 17.62 13.86 26 237132 881 34718892
Skin cancer 17.60 13.86 125 237033 10172 34709601
Brain herniation 17.58 13.86 3 237155 4005 34715768
Cholecystitis acute 17.52 13.86 11 237147 6428 34713345
Dysstasia 17.45 13.86 142 237016 12053 34707720
Pulmonary function test decreased 17.39 13.86 6 237152 4969 34714804
Lip and/or oral cavity cancer 17.38 13.86 17 237141 370 34719403
Hyperhidrosis 17.37 13.86 386 236772 75306 34644467
Hypertriglyceridaemia 17.34 13.86 19 237139 8429 34711344
Granuloma 17.32 13.86 55 237103 3196 34716577
Multiple sclerosis 17.31 13.86 90 237068 6555 34713218
Spinal laminectomy 17.30 13.86 15 237143 278 34719495
Dactylitis 17.30 13.86 26 237132 896 34718877
Pneumonia bacterial 17.23 13.86 34 237124 11838 34707935
Tendon pain 17.19 13.86 52 237106 2943 34716830
Photosensitivity reaction 17.18 13.86 127 237031 10467 34709306
Metabolic disorder 17.13 13.86 4 237154 4279 34715494
Pneumothorax 17.08 13.86 69 237089 19023 34700750
Pneumatosis intestinalis 17.07 13.86 3 237155 3920 34715853
Breath sounds abnormal 17.07 13.86 13 237145 6868 34712905
Blood thyroid stimulating hormone increased 16.96 13.86 4 237154 4251 34715522
Blood triglycerides increased 16.94 13.86 45 237113 14114 34705659
Cholecystitis 16.94 13.86 29 237129 10659 34709114
Sinus node dysfunction 16.93 13.86 4 237154 4245 34715528
Ear neoplasm 16.92 13.86 9 237149 70 34719703
Axial spondyloarthritis 16.82 13.86 16 237142 336 34719437
Papule 16.81 13.86 64 237094 4075 34715698
C-reactive protein decreased 16.79 13.86 40 237118 1962 34717811
Foot fracture 16.79 13.86 73 237085 4938 34714835
Generalised oedema 16.77 13.86 37 237121 12371 34707402
Infected cyst 16.73 13.86 20 237138 550 34719223
Ileus paralytic 16.66 13.86 10 237148 5987 34713786
Septic arthritis staphylococcal 16.64 13.86 19 237139 497 34719276
Ligament disorder 16.61 13.86 11 237147 133 34719640
Yolk sac tumour site unspecified 16.57 13.86 5 237153 5 34719768
Hypertensive crisis 16.55 13.86 21 237137 8730 34711043
Manufacturing product shipping issue 16.55 13.86 7 237151 30 34719743
Spinal fusion acquired 16.55 13.86 7 237151 30 34719743
Scar 16.53 13.86 82 237076 5862 34713911
Cytomegalovirus infection reactivation 16.51 13.86 7 237151 5111 34714662
Gastric operation 16.49 13.86 8 237150 50 34719723
Peripheral sensory neuropathy 16.48 13.86 13 237145 6747 34713026
Eating disorder 16.40 13.86 19 237139 8221 34711552
HLA-B*27 positive 16.37 13.86 7 237151 31 34719742
Carbuncle 16.37 13.86 7 237151 31 34719742
Syringe issue 16.36 13.86 9 237149 5655 34714118
Skin irritation 16.27 13.86 78 237080 5499 34714274
Coronary artery stenosis 16.26 13.86 25 237133 9591 34710182
Dementia 16.22 13.86 44 237114 13704 34706069
Infection susceptibility increased 16.21 13.86 22 237136 689 34719084
Ankle arthroplasty 16.10 13.86 5 237153 6 34719767
Injection site oedema 16.07 13.86 13 237145 218 34719555
Dermatitis psoriasiform 16.06 13.86 33 237125 1463 34718310
Lower limb fracture 16.06 13.86 63 237095 4068 34715705
Secondary amyloidosis 16.01 13.86 9 237149 79 34719694
X-ray abnormal 16.00 13.86 18 237140 463 34719310
Cast application 16 13.86 4 237154 0 34719773
Anticipatory anxiety 16 13.86 4 237154 0 34719773
Self-consciousness 15.98 13.86 8 237150 54 34719719
Carotid artery stenosis 15.98 13.86 7 237151 5012 34714761
Wisdom teeth removal 15.97 13.86 10 237148 109 34719664
Body temperature abnormal 15.96 13.86 21 237137 638 34719135
Enterococcal infection 15.93 13.86 24 237134 9282 34710491
Penile squamous cell carcinoma 15.92 13.86 9 237149 80 34719693
Mixed connective tissue disease 15.86 13.86 7 237151 34 34719739
Muscle haemorrhage 15.84 13.86 3 237155 3715 34716058
Paradoxical psoriasis 15.80 13.86 6 237152 18 34719755
Seminoma 15.78 13.86 13 237145 224 34719549
Ammonia increased 15.74 13.86 5 237153 4364 34715409
Sudden cardiac death 15.74 13.86 3 237155 3698 34716075
Diabetes mellitus 15.71 13.86 423 236735 46450 34673323
Bursitis 15.68 13.86 76 237082 5382 34714391
Gastric ulcer 15.67 13.86 54 237104 15596 34704177
Vascular graft 15.67 13.86 33 237125 1489 34718284
Affect lability 15.63 13.86 3 237155 3680 34716093
Cholelithiasis 15.61 13.86 82 237076 21066 34698707
Abdominal pain lower 15.58 13.86 30 237128 10541 34709232
Renal tubular disorder 15.55 13.86 6 237152 4637 34715136
Precancerous skin lesion 15.54 13.86 20 237138 594 34719179
Tinea infection 15.54 13.86 13 237145 229 34719544
Nail discolouration 15.51 13.86 26 237132 985 34718788
Soft tissue swelling 15.49 13.86 19 237139 537 34719236
Muscle tightness 15.49 13.86 70 237088 4814 34714959
Mental impairment 15.47 13.86 29 237129 10293 34709480
Angioimmunoblastic T-cell lymphoma 15.43 13.86 15 237143 324 34719449
Papillary cystadenoma lymphomatosum 15.38 13.86 7 237151 37 34719736
Drug ineffective for unapproved indication 15.33 13.86 96 237062 23619 34696154
Metabolic encephalopathy 15.31 13.86 5 237153 4287 34715486
Testicular seminoma (pure) 15.29 13.86 8 237150 60 34719713
Maternal drugs affecting foetus 15.28 13.86 4 237154 3961 34715812
Gingival discolouration 15.28 13.86 5 237153 8 34719765
Muscular weakness 15.26 13.86 377 236781 72520 34647253
Nasal cavity cancer 15.25 13.86 12 237146 193 34719580
Intracranial pressure increased 15.22 13.86 4 237154 3951 34715822
Polyneuropathy 15.19 13.86 51 237107 14845 34704928
Erythema multiforme 15.10 13.86 22 237136 8627 34711146
Alcohol poisoning 15.09 13.86 3 237155 3590 34716183
Pyelonephritis 15.09 13.86 12 237146 6203 34713570
Peripheral ischaemia 15.08 13.86 10 237148 5677 34714096
Abdominal discomfort 14.98 13.86 521 236637 59314 34660459
Arthroscopy 14.86 13.86 9 237149 92 34719681
Dermatitis bullous 14.84 13.86 15 237143 6907 34712866
Nasal discharge discolouration 14.84 13.86 14 237144 291 34719482
Pseudomonal sepsis 14.82 13.86 3 237155 3544 34716229
Xyphoid retraction 14.79 13.86 11 237147 162 34719611
Jaundice cholestatic 14.77 13.86 7 237151 4787 34714986
Muscle spasticity 14.76 13.86 11 237147 5877 34713896
Diaphragmatic injury 14.75 13.86 10 237148 126 34719647
Serum ferritin increased 14.75 13.86 12 237146 6134 34713639
Oral infection 14.72 13.86 39 237119 2044 34717729
Gastrointestinal perforation 14.69 13.86 4 237154 3859 34715914
Oesophageal infection 14.68 13.86 14 237144 295 34719478
Granuloma skin 14.67 13.86 29 237129 1250 34718523
Drug tolerance 14.66 13.86 48 237110 2834 34716939
Myelitis 14.65 13.86 23 237135 824 34718949
Hospitalisation 14.58 13.86 285 236873 56617 34663156
Eosinophilic pneumonia 14.55 13.86 3 237155 3498 34716275
Neutrophilia 14.44 13.86 5 237153 4132 34715641
Upper-airway cough syndrome 14.43 13.86 55 237103 3503 34716270
Mycobacterial infection 14.36 13.86 42 237116 2332 34717441
Superficial spreading melanoma stage unspecified 14.35 13.86 11 237147 170 34719603
Ejection fraction decreased 14.29 13.86 74 237084 19080 34700693
Bronchiectasis 14.28 13.86 28 237130 9773 34710000
Impaired gastric emptying 14.26 13.86 3 237155 3450 34716323
Portal vein thrombosis 14.26 13.86 4 237154 3784 34715989
Arthroscopic surgery 14.26 13.86 5 237153 11 34719762
Odynophagia 14.25 13.86 10 237148 5511 34714262
Pulmonary tuberculosis 14.24 13.86 67 237091 4687 34715086
Bacterial sepsis 14.24 13.86 9 237149 5241 34714532
Periarthritis 14.19 13.86 26 237132 1058 34718715
Blood albumin decreased 14.16 13.86 46 237112 13526 34706247
Hydrocephalus 14.15 13.86 9 237149 5223 34714550
Benign neoplasm of thyroid gland 14.13 13.86 6 237152 26 34719747
Protein urine present 14.13 13.86 9 237149 5219 34714554
Drug use disorder 14.00 13.86 61 237097 4130 34715643
Intestinal perforation 13.98 13.86 25 237133 9035 34710738
Ear pain 13.97 13.86 74 237084 5428 34714345
Orthosis user 13.96 13.86 5 237153 12 34719761
Echinococciasis 13.96 13.86 5 237153 12 34719761
Ocular sarcoidosis 13.96 13.86 5 237153 12 34719761
Hemiplegia 13.96 13.86 16 237142 6956 34712817
Necrosis 13.96 13.86 11 237147 5712 34714061
Intervertebral disc injury 13.95 13.86 6 237152 27 34719746
Aspergillus infection 13.88 13.86 40 237118 12214 34707559
Systemic inflammatory response syndrome 13.87 13.86 15 237143 6694 34713079

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Injection site pain 48976.75 13.87 26208 956708 103630 78657842
Injection site erythema 47604.30 13.87 21873 961043 56324 78705148
Injection site pruritus 26104.73 13.87 11961 970955 30322 78731150
Injection site swelling 25651.43 13.87 12219 970697 34913 78726559
Injection site reaction 18430.47 13.87 10279 972637 44506 78716966
Injection site bruising 16543.56 13.87 8681 974235 32321 78729151
Injection site warmth 13575.15 13.87 5543 977373 9264 78752208
Arthralgia 10406.11 13.87 22173 960743 549630 78211842
Drug ineffective 8781.94 13.87 31136 951780 1049777 77711695
Wrong technique in product usage process 8581.35 13.87 7182 975734 66693 78694779
Injection site rash 7992.74 13.87 4064 978852 13890 78747582
Injection site haemorrhage 7786.66 13.87 4638 978278 23232 78738240
Injection site urticaria 6189.93 13.87 3067 979849 9759 78751713
Joint swelling 5941.48 13.87 11801 971115 276845 78484627
Pain in extremity 5659.47 13.87 13294 969622 351244 78410228
Acute kidney injury 4839.90 13.87 426 982490 518978 78242494
Pain 4750.47 13.87 19156 963760 684646 78076826
Nasopharyngitis 4652.52 13.87 9898 973018 243983 78517489
Injection site discolouration 4330.82 13.87 2038 980878 5576 78755896
Therapeutic product effect decreased 4165.49 13.87 7340 975576 156523 78604949
Product storage error 4065.13 13.87 2519 980397 13707 78747765
Toxicity to various agents 4012.85 13.87 314 982602 421226 78340246
Sinusitis 3889.72 13.87 7887 975029 187614 78573858
Injection site induration 3870.73 13.87 2049 980867 7770 78753702
Drug interaction 3789.66 13.87 369 982547 414814 78346658
Product dose omission issue 3773.20 13.87 8971 973945 238566 78522906
Therapeutic product effect incomplete 3691.63 13.87 6416 976500 135229 78626243
Device issue 3635.15 13.87 2868 980048 24240 78737232
Accidental exposure to product 3501.65 13.87 2981 979935 28341 78733131
Hypotension 3435.12 13.87 638 982278 439679 78321793
Musculoskeletal stiffness 3334.87 13.87 6937 975979 168071 78593401
Anaemia 2972.88 13.87 898 982018 444117 78317355
Completed suicide 2888.95 13.87 25 982891 245742 78515730
Injection site mass 2863.37 13.87 2208 980708 17976 78743496
Mobility decreased 2773.21 13.87 5213 977703 116962 78644510
Death 2744.09 13.87 1809 981107 564705 78196767
Swelling 2559.46 13.87 7138 975778 209573 78551899
Febrile neutropenia 2507.07 13.87 74 982842 230925 78530547
Neutropenia 2239.50 13.87 418 982498 287292 78474180
Therapeutic response decreased 2178.53 13.87 3352 979564 63501 78697971
Treatment failure 2159.30 13.87 5763 977153 164723 78596749
Musculoskeletal pain 2104.11 13.87 4189 978727 98165 78663307
Joint stiffness 2025.48 13.87 2508 980408 38322 78723150
Thrombocytopenia 2016.61 13.87 408 982508 264851 78496621
Dyspnoea 1947.86 13.87 4859 978057 852166 77909306
Hyponatraemia 1933.08 13.87 56 982860 177792 78583680
Underdose 1855.12 13.87 2165 980751 30986 78730486
Arthropathy 1831.49 13.87 5565 977351 171546 78589926
Arthritis 1825.81 13.87 4236 978680 110644 78650828
Injection site discomfort 1749.52 13.87 975 981941 4191 78757281
Drug abuse 1736.68 13.87 60 982856 162631 78598841
Drug intolerance 1640.91 13.87 7025 975891 257094 78504378
Malignant neoplasm progression 1616.39 13.87 10 982906 135980 78625492
Constipation 1603.63 13.87 741 982175 282309 78479163
Synovitis 1594.55 13.87 4775 978141 145959 78615513
Contraindicated product administered 1572.55 13.87 4890 978026 152648 78608824
Peripheral swelling 1562.93 13.87 7024 975892 262593 78498879
Cardiac arrest 1554.84 13.87 158 982758 171938 78589534
Therapy interrupted 1552.56 13.87 1924 980992 29417 78732055
Dehydration 1524.47 13.87 576 982340 247611 78513861
Psoriasis 1479.11 13.87 3354 979562 86233 78675239
Bradycardia 1450.26 13.87 49 982867 135508 78625964
Disease progression 1429.31 13.87 270 982646 184092 78577380
Abdominal pain 1411.51 13.87 1634 981282 387935 78373537
Diarrhoea 1404.18 13.87 5844 977072 874645 77886827
Injection site haematoma 1393.59 13.87 821 982095 4006 78757466
Tachycardia 1349.35 13.87 274 982642 177494 78583978
Injection site extravasation 1341.30 13.87 1044 981872 8625 78752847
Respiratory failure 1336.04 13.87 297 982619 180614 78580858
Vomiting 1311.09 13.87 4042 978874 661786 78099686
Hyperkalaemia 1301.69 13.87 21 982895 114377 78647095
Pancytopenia 1290.64 13.87 240 982676 165505 78595967
Respiratory tract congestion 1250.16 13.87 1382 981534 18572 78742900
Seizure 1223.23 13.87 401 982515 188433 78573039
Hypokalaemia 1214.98 13.87 167 982749 143873 78617599
Gastrointestinal haemorrhage 1200.46 13.87 191 982725 147528 78613944
Haemoglobin decreased 1196.30 13.87 622 982294 221497 78539975
Intentional overdose 1190.98 13.87 23 982893 105937 78655535
Skin plaque 1184.89 13.87 1015 981901 9730 78751742
Rhabdomyolysis 1168.93 13.87 20 982896 103111 78658361
Knee arthroplasty 1120.92 13.87 1956 980960 41292 78720180
Platelet count decreased 1112.35 13.87 503 982413 194161 78567311
Cardio-respiratory arrest 1088.96 13.87 61 982855 108449 78653023
Musculoskeletal disorder 1085.32 13.87 1331 981585 20117 78741355
Sepsis 1079.61 13.87 1037 981879 268391 78493081
Overdose 1058.74 13.87 472 982444 183734 78577738
Electrocardiogram QT prolonged 1057.57 13.87 10 982906 90376 78671096
Renal failure 1045.31 13.87 588 982328 200380 78561092
Surgery 1037.73 13.87 1622 981294 31144 78730328
Syncope 1032.63 13.87 459 982457 178990 78582482
Hypoxia 1030.04 13.87 60 982856 103183 78658289
Atrial fibrillation 1022.04 13.87 584 982332 197302 78564170
Depressed level of consciousness 989.82 13.87 48 982868 96604 78664868
Confusional state 979.86 13.87 1502 981414 316495 78444977
Hypoglycaemia 978.17 13.87 71 982845 101523 78659949
Oxygen saturation decreased 972.75 13.87 202 982714 128845 78632627
Somnolence 964.14 13.87 914 982002 238067 78523405
Oropharyngeal pain 927.72 13.87 3213 979703 106140 78655332
Injection site macule 920.98 13.87 319 982597 223 78761249
Decreased appetite 917.28 13.87 1768 981148 340650 78420822
Product use in unapproved indication 914.72 13.87 1042 981874 249317 78512155
Influenza 905.05 13.87 3576 979340 126030 78635442
International normalised ratio increased 901.25 13.87 32 982884 84689 78676783
Cardiac failure 898.84 13.87 391 982525 154451 78607021
Injection site recall reaction 897.78 13.87 288 982628 99 78761373
Metabolic acidosis 882.03 13.87 30 982886 82499 78678973
Agitation 878.84 13.87 100 982816 99615 78661857
Drug hypersensitivity 865.96 13.87 6478 976438 292438 78469034
Multiple organ dysfunction syndrome 860.64 13.87 211 982705 120035 78641437
Infection 854.37 13.87 5500 977416 236212 78525260
Neutrophil count decreased 854.32 13.87 84 982832 93875 78667597
Bronchitis 852.80 13.87 3530 979386 127114 78634358
Blood creatinine increased 845.38 13.87 427 982489 154630 78606842
Coma 838.59 13.87 121 982795 100528 78660944
Pulmonary embolism 815.30 13.87 558 982358 171096 78590376
Suicide attempt 809.88 13.87 54 982862 82878 78678594
Lactic acidosis 808.57 13.87 11 982905 70348 78691124
Incorrect dose administered by device 808 13.87 591 982325 4398 78757074
Cardiac failure congestive 787.09 13.87 385 982531 142017 78619455
Finger deformity 785.63 13.87 687 982229 6787 78754685
Nodule 774.10 13.87 1171 981745 21823 78739649
C-reactive protein abnormal 772.72 13.87 1788 981128 46579 78714893
Red blood cell sedimentation rate abnormal 756.57 13.87 1103 981813 19860 78741612
Hypersensitivity 752.97 13.87 5672 977244 256567 78504905
Unevaluable event 752.68 13.87 1928 980988 53657 78707815
Blood pressure decreased 734.68 13.87 163 982753 99303 78662169
Injection site vesicles 729.17 13.87 461 982455 2611 78758861
Psoriatic arthropathy 724.44 13.87 2363 980553 75636 78685836
Renal impairment 704.95 13.87 547 982369 157236 78604236
Pleural effusion 698.11 13.87 466 982450 144796 78616676
Injury associated with device 697.38 13.87 471 982445 3035 78758437
Hallucination 691.70 13.87 113 982803 85632 78675840
Drug reaction with eosinophilia and systemic symptoms 670.58 13.87 28 982888 64216 78697256
Headache 657.18 13.87 11508 971408 642264 78119208
Inflammation 648.03 13.87 2579 980337 91174 78670298
Weight decreased 646.07 13.87 2230 980686 352968 78408504
White blood cell count decreased 643.66 13.87 825 982091 187463 78574009
Hyperglycaemia 641.72 13.87 62 982854 70273 78691199
Mental status changes 638.26 13.87 49 982867 66910 78694562
Ascites 636.11 13.87 88 982828 75474 78685998
Therapy non-responder 635.46 13.87 2536 980380 89769 78671703
Deep vein thrombosis 635.43 13.87 349 982567 120570 78640902
Fear of injection 633.47 13.87 609 982307 6865 78754607
Asthenia 632.35 13.87 3709 979207 507980 78253492
Hand deformity 630.82 13.87 2747 980169 101172 78660300
Foot deformity 620.06 13.87 1086 981830 22988 78738484
Alopecia 618.90 13.87 4923 977993 226432 78535040
Injection site irritation 618.40 13.87 451 982465 3339 78758133
Pulmonary oedema 617.74 13.87 162 982754 88092 78673380
Blood bilirubin increased 616.00 13.87 54 982862 66178 78695294
Acute myocardial infarction 613.69 13.87 105 982811 76931 78684541
Pneumonia aspiration 605.82 13.87 61 982855 66906 78694566
Melaena 599.42 13.87 38 982878 60852 78700620
Blood creatine phosphokinase increased 598.40 13.87 60 982856 66030 78695442
Paranasal sinus hypersecretion 583.37 13.87 438 982478 3408 78758064
Blood pressure increased 581.58 13.87 1073 981843 210287 78551185
Neoplasm progression 581.58 13.87 11 982905 51671 78709801
Encephalopathy 575.65 13.87 75 982841 67322 78694150
Sedation 572.34 13.87 14 982902 51881 78709591
General physical health deterioration 570.81 13.87 1628 981288 273610 78487862
Orthostatic hypotension 568.33 13.87 30 982886 56134 78705338
Injection site inflammation 568.22 13.87 437 982479 3539 78757933
Unresponsive to stimuli 563.89 13.87 30 982886 55758 78705714
Respiratory arrest 557.45 13.87 39 982877 57511 78703961
Septic shock 557.08 13.87 419 982497 122382 78639090
Herpes zoster 550.83 13.87 2442 980474 90641 78670831
Nausea 549.86 13.87 8402 974514 948794 77812678
Pyrexia 540.70 13.87 5554 977362 673155 78088317
Drug dose omission by device 534.88 13.87 512 982404 5738 78755734
Loss of consciousness 534.49 13.87 775 982141 167168 78594304
Dysarthria 532.46 13.87 95 982821 67527 78693945
Multiple sclerosis relapse 531.54 13.87 8 982908 46525 78714947
Mucosal inflammation 524.68 13.87 141 982775 75439 78686033
Tremor 523.69 13.87 803 982113 169280 78592192
Ear infection 518.55 13.87 1244 981672 33188 78728284
Neck pain 517.43 13.87 2070 980846 73347 78688125
Condition aggravated 517.08 13.87 8861 974055 492263 78269209
Heart rate increased 511.26 13.87 441 982475 120283 78641189
Rhinorrhoea 510.74 13.87 2074 980842 74000 78687472
Serotonin syndrome 509.05 13.87 9 982907 45018 78716454
Hypomagnesaemia 508.60 13.87 15 982901 46896 78714576
Respiratory distress 505.35 13.87 62 982854 58277 78703195
Red blood cell sedimentation rate increased 498.98 13.87 1470 981446 44472 78717000
Coronary artery disease 496.37 13.87 101 982815 65373 78696099
Dyspnoea exertional 495.53 13.87 226 982690 86847 78674625
Gait disturbance 493.14 13.87 4300 978616 203206 78558266
Grip strength decreased 487.79 13.87 927 981989 20942 78740530
Upper respiratory tract infection 486.99 13.87 2321 980595 88847 78672625
Pharyngitis streptococcal 480.30 13.87 626 982290 10088 78751384
Leukopenia 476.14 13.87 440 982476 116073 78645399
Haematuria 472.99 13.87 131 982785 68705 78692767
Contusion 470.82 13.87 3295 979621 145481 78615991
Urinary retention 464.94 13.87 71 982845 56559 78704913
Impaired healing 464.17 13.87 2226 980690 85429 78676043
Cholestasis 459.75 13.87 52 982864 52057 78709415
Hip arthroplasty 458.14 13.87 1215 981701 34541 78726931
Bone marrow failure 455.97 13.87 49 982867 51058 78710414
Blood alkaline phosphatase increased 454.90 13.87 112 982804 63552 78697920
Haematemesis 454.04 13.87 55 982861 52209 78709263
Hepatic failure 452.62 13.87 100 982816 61112 78700360
Delirium 452.26 13.87 239 982677 84388 78677084
Acute respiratory failure 451.06 13.87 92 982824 59449 78702023
Toxic epidermal necrolysis 450.50 13.87 24 982892 44557 78716915
Alanine aminotransferase increased 450.07 13.87 822 982094 161748 78599724
Fall 445.70 13.87 3855 979061 483774 78277698
Aggression 444.23 13.87 53 982863 50905 78710567
Drug level increased 443.90 13.87 9 982907 39642 78721830
Disorientation 443.59 13.87 113 982803 62663 78698809
Lymphocyte count decreased 438.56 13.87 39 982877 47250 78714222
Aspartate aminotransferase increased 437.95 13.87 643 982273 137998 78623474
Cerebral haemorrhage 435.06 13.87 90 982826 57583 78703889
Haematochezia 434.87 13.87 271 982645 87374 78674098
Agranulocytosis 434.74 13.87 31 982885 44999 78716473
Pneumonia 432.15 13.87 5643 977273 654603 78106869
Heart rate decreased 431.59 13.87 163 982753 70153 78691319
Chest pain 430.06 13.87 1902 981014 280402 78481070
Cardiogenic shock 428.49 13.87 21 982895 41893 78719579
Angioedema 427.01 13.87 201 982715 75834 78685638
Bone erosion 423.64 13.87 777 982139 17070 78744402
Dizziness 422.38 13.87 4299 978617 522142 78239330
Suicidal ideation 422.31 13.87 206 982710 76134 78685338
Hypervolaemia 422.12 13.87 26 982890 42664 78718808
Gamma-glutamyltransferase increased 421.54 13.87 81 982835 54599 78706873
Jaundice 415.60 13.87 77 982839 53272 78708200
Shock 414.66 13.87 32 982884 43516 78717956
Rectal haemorrhage 414.39 13.87 211 982705 76089 78685383
Chronic kidney disease 413.37 13.87 149 982767 66005 78695467
Cerebrovascular accident 409.87 13.87 808 982108 154484 78606988
Plasma cell myeloma 408.24 13.87 80 982836 53179 78708293
Feeling abnormal 405.04 13.87 3350 979566 155849 78605623
Blood pressure systolic increased 404.97 13.87 159 982757 66827 78694645
Ventricular tachycardia 404.47 13.87 29 982887 41906 78719566
Blood urea increased 403.23 13.87 60 982856 48730 78712742
Loss of personal independence in daily activities 403.16 13.87 2400 980516 100180 78661292
Dysphagia 403.10 13.87 549 982367 121587 78639885
Neuropathy peripheral 401.45 13.87 703 982213 140602 78620870
Sinus congestion 399.62 13.87 807 982109 19089 78742383
Psychotic disorder 395.42 13.87 30 982886 41372 78720100
Upper gastrointestinal haemorrhage 395.16 13.87 30 982886 41350 78720122
Altered state of consciousness 390.99 13.87 42 982874 43780 78717692
Eosinophilia 390.77 13.87 49 982867 45296 78716176
Adverse event 390.25 13.87 1624 981292 58590 78702882
Joint range of motion decreased 389.55 13.87 1094 981822 32188 78729284
Sinus headache 387.86 13.87 391 982525 4689 78756783
Rheumatoid factor positive 379.32 13.87 1603 981313 58236 78703236
Pancreatitis acute 379.19 13.87 75 982841 49529 78711943
Osteoarthritis 373.96 13.87 2090 980826 85219 78676253
Malaise 373.86 13.87 8276 974640 481593 78279879
Back pain 371.17 13.87 5533 977383 298647 78462825
Hepatocellular injury 363.72 13.87 72 982844 47521 78713951
Accidental overdose 360.76 13.87 35 982881 39546 78721926
Injection site hypersensitivity 360.11 13.87 249 982667 1676 78759796
Cognitive disorder 359.85 13.87 207 982709 69719 78691753
Arrhythmia 358.14 13.87 153 982763 61119 78700353
Knee operation 356.60 13.87 400 982516 5466 78756006
Blood glucose increased 356.54 13.87 540 982376 114435 78647037
Transplant dysfunction 353.82 13.87 441 982475 6780 78754692
Generalised tonic-clonic seizure 353.81 13.87 58 982858 43852 78717620
Blood lactate dehydrogenase increased 353.45 13.87 36 982880 39134 78722338
Therapy cessation 353.17 13.87 1143 981773 36419 78725053
Systemic lupus erythematosus 353.12 13.87 2631 980285 118518 78642954
Circulatory collapse 352.21 13.87 30 982886 37638 78723834
Hypocalcaemia 346.76 13.87 93 982823 49831 78711641
Drug withdrawal syndrome 343.71 13.87 21 982895 34697 78726775
Haemorrhage 343.68 13.87 369 982547 90749 78670723
Sinus tachycardia 343.45 13.87 30 982886 36878 78724594
Stevens-Johnson syndrome 343.23 13.87 40 982876 39126 78722346
Pulmonary hypertension 342.70 13.87 85 982831 47995 78713477
Myocardial infarction 342.49 13.87 1144 981772 182985 78578487
COVID-19 342.00 13.87 912 982004 156762 78604710
Disability 339.80 13.87 691 982225 16429 78745043
Rash maculo-papular 337.53 13.87 134 982782 55944 78705528
Injection site nodule 335.55 13.87 316 982600 3464 78758008
Osteonecrosis of jaw 333.28 13.87 64 982852 43162 78718310
Myelosuppression 331.99 13.87 50 982866 40246 78721226
Leukocytosis 331.54 13.87 66 982850 43389 78718083
Diabetic ketoacidosis 330.82 13.87 23 982893 34099 78727373
Foot operation 329.96 13.87 380 982536 5353 78756119
Cough 329.61 13.87 6349 976567 360440 78401032
Joint destruction 326.43 13.87 384 982532 5541 78755931
Intentional self-injury 325.86 13.87 18 982898 32401 78729071
Haematocrit decreased 324.89 13.87 175 982741 61137 78700335
Flushing 323.51 13.87 366 982550 87902 78673570
Adverse reaction 322.98 13.87 481 982435 8833 78752639
Neuroleptic malignant syndrome 322.56 13.87 3 982913 27556 78733916
Cerebral infarction 321.21 13.87 83 982833 45593 78715879
Anxiety 321.01 13.87 1774 981142 246738 78514734
Labelled drug-drug interaction medication error 319.09 13.87 4 982912 27646 78733826
Tachypnoea 318.61 13.87 19 982897 32044 78729428
Blood pressure fluctuation 313.68 13.87 222 982694 66923 78694549
Increased tendency to bruise 313.33 13.87 505 982411 9959 78751513
Palpitations 311.12 13.87 686 982230 125924 78635548
Therapeutic product effect delayed 310.17 13.87 275 982641 2771 78758701
Ventricular fibrillation 308.14 13.87 22 982894 31904 78729568
Acute respiratory distress syndrome 308.13 13.87 81 982835 43986 78717486
Inappropriate antidiuretic hormone secretion 307.33 13.87 3 982913 26310 78735162
Tubulointerstitial nephritis 304.75 13.87 52 982864 38183 78723289
Hallucination, visual 300.79 13.87 28 982888 32701 78728771
Myoclonus 299.28 13.87 9 982907 27651 78733821
Sleep disorder due to general medical condition, insomnia type 299.07 13.87 1196 981720 42360 78719112
Device expulsion 297.30 13.87 4 982912 25857 78735615
Haematoma 296.13 13.87 136 982780 52059 78709413
Aphasia 295.82 13.87 103 982813 46629 78714843
Spinal operation 295.04 13.87 423 982493 7494 78753978
Acute hepatic failure 292.81 13.87 20 982896 30093 78731379
Injection site injury 292.72 13.87 156 982760 601 78760871
Oedema peripheral 292.48 13.87 1864 981052 250424 78511048
Abnormal behaviour 291.46 13.87 49 982867 36372 78725100
Posterior reversible encephalopathy syndrome 290.14 13.87 7 982909 26274 78735198
Tooth infection 289.59 13.87 686 982230 18146 78743326
Subdural haematoma 288.60 13.87 27 982889 31407 78730065
Pulmonary arterial hypertension 287.46 13.87 15 982901 28351 78733121
Arthropod bite 287.36 13.87 433 982483 8038 78753434
Ejection fraction decreased 286.94 13.87 42 982874 34535 78726937
Limb discomfort 286.01 13.87 974 981942 31876 78729596
Localised infection 285.98 13.87 1066 981850 36509 78724963
Hepatic enzyme increased 285.78 13.87 3475 979441 179135 78582337
Oedema 285.60 13.87 658 982258 118922 78642550
Hypertension 285.22 13.87 2655 980261 328337 78433135
Electrolyte imbalance 284.92 13.87 26 982890 30855 78730617
Sneezing 282.34 13.87 698 982218 18985 78742487
Restlessness 281.61 13.87 110 982806 46382 78715090
Abdominal distension 281.26 13.87 664 982252 118986 78642486
Status epilepticus 279.06 13.87 6 982910 25035 78736437
Poisoning 277.98 13.87 7 982909 25265 78736207
Acne 275.43 13.87 849 982067 26341 78735131
Neutropenic sepsis 275.25 13.87 14 982902 27050 78734422
Adverse drug reaction 274.84 13.87 1575 981341 64817 78696655
Colitis 274.09 13.87 299 982617 73008 78688464
Joint lock 273.72 13.87 263 982653 2962 78758510
Rheumatoid nodule 272.26 13.87 639 982277 16799 78744673
Fibromyalgia 272.05 13.87 1535 981381 62805 78698667
Coagulopathy 271.96 13.87 56 982860 35950 78725522
Renal tubular necrosis 271.45 13.87 8 982908 25031 78736441
Haemorrhage intracranial 271.39 13.87 12 982904 26181 78735291
Epilepsy 271.07 13.87 83 982833 40777 78720695
Blood calcium decreased 270.28 13.87 36 982880 31783 78729689
Chondrolysis 269.97 13.87 117 982799 244 78761228
Pericardial effusion 269.36 13.87 116 982800 46121 78715351
Sinus disorder 264.45 13.87 740 982176 21724 78739748
Pneumonitis 264.13 13.87 217 982699 60643 78700829
Anti-cyclic citrullinated peptide antibody positive 263.79 13.87 1843 981073 81300 78680172
Haemoptysis 263.10 13.87 184 982732 55815 78705657
Small intestinal obstruction 262.61 13.87 19 982897 27253 78734219
Iritis 262.41 13.87 279 982637 3576 78757896
Clostridium difficile colitis 261.54 13.87 42 982874 32241 78729231
Sinus bradycardia 260.17 13.87 12 982904 25235 78736237
Ischaemic stroke 257.67 13.87 48 982868 33083 78728389
Hepatic encephalopathy 257.41 13.87 9 982907 24157 78737315
Hepatic function abnormal 257.31 13.87 313 982603 72794 78688678
Pancreatitis 257.16 13.87 279 982637 68296 78693176
Nasal congestion 256.58 13.87 1720 981196 74832 78686640
Dyskinesia 253.48 13.87 117 982799 44656 78716816
Device malfunction 251.96 13.87 706 982210 20742 78740730
Hyperbilirubinaemia 251.53 13.87 12 982904 24506 78736966
Abdominal discomfort 251.51 13.87 4416 978500 246311 78515161
Shoulder arthroplasty 251.29 13.87 253 982663 3029 78758443
Pemphigus 248.60 13.87 2087 980829 97495 78663977
Angina pectoris 247.01 13.87 167 982749 51565 78709907
Cytomegalovirus infection 243.66 13.87 110 982806 42534 78718938
Chondropathy 242.37 13.87 220 982696 2292 78759180
COVID-19 pneumonia 241.83 13.87 34 982882 28815 78732657
Corrective lens user 240.04 13.87 98 982818 163 78761309
Hepatic cytolysis 239.74 13.87 27 982889 27124 78734348
Extrapyramidal disorder 239.65 13.87 9 982907 22670 78738802
Obstructive airways disorder 239.54 13.87 48 982868 31411 78730061
Rash 239.03 13.87 9045 973871 569313 78192159
Joint noise 238.18 13.87 269 982647 3705 78757767
Extra dose administered 236.95 13.87 395 982521 8020 78753452
Gastrooesophageal reflux disease 236.73 13.87 589 982327 103657 78657815
Exposure during pregnancy 236.28 13.87 563 982353 100569 78660903
Fluid retention 234.13 13.87 310 982606 69499 78691973
Lethargy 233.95 13.87 401 982515 80891 78680581
Disseminated intravascular coagulation 233.85 13.87 75 982841 35767 78725705
Hypothermia 233.78 13.87 11 982905 22735 78738737
Right ventricular failure 233.25 13.87 14 982902 23483 78737989
Presyncope 232.85 13.87 107 982809 40947 78720525
Tumour lysis syndrome 232.47 13.87 16 982900 23923 78737549
Joint effusion 228.59 13.87 610 982306 17404 78744068
Mycobacterium tuberculosis complex test positive 228.16 13.87 223 982693 2569 78758903
Cyanosis 227.58 13.87 23 982893 25159 78736313
Joint injury 226.92 13.87 875 982041 30460 78731012
Withdrawal syndrome 226.63 13.87 31 982885 26823 78734649
Bacteraemia 224.48 13.87 63 982853 32761 78728711
Decreased immune responsiveness 224.09 13.87 306 982610 5169 78756303
Urinary incontinence 223.81 13.87 112 982804 40797 78720675
Lymphopenia 223.72 13.87 51 982865 30506 78730966
Ovarian cyst 223.50 13.87 487 982429 12168 78749304
Chest discomfort 222.95 13.87 909 982007 137135 78624337
Hemiparesis 222.92 13.87 69 982847 33664 78727808
Pallor 222.89 13.87 174 982742 49888 78711584
Intentional product misuse 222.64 13.87 1966 980950 93199 78668273
Anuria 222.62 13.87 8 982908 20955 78740517
Ill-defined disorder 222.50 13.87 1483 981433 64392 78697080
Joint arthroplasty 222.33 13.87 218 982698 2522 78758950
Drug ineffective for unapproved indication 221.97 13.87 183 982733 51055 78710417
Ileus 221.82 13.87 30 982886 26181 78735291
Product prescribing error 220.29 13.87 140 982776 44673 78716799
Blood pressure diastolic decreased 220.09 13.87 51 982865 30165 78731307
Shoulder operation 219.66 13.87 217 982699 2535 78758937
Dystonia 217.84 13.87 11 982905 21388 78740084
Balance disorder 216.42 13.87 569 982347 98288 78663184
Spinal fusion surgery 216.28 13.87 294 982622 4944 78756528
Brain oedema 215.98 13.87 28 982888 25235 78736237
Tuberculin test positive 215.09 13.87 237 982679 3171 78758301
Hypophagia 214.54 13.87 148 982768 45219 78716253
Intentional product use issue 214.18 13.87 1054 981862 151058 78610414
Breast cancer 213.31 13.87 904 982012 32877 78728595
Transaminases increased 212.99 13.87 194 982722 51549 78709923
Transient ischaemic attack 212.86 13.87 201 982715 52494 78708978
Device difficult to use 212.81 13.87 494 982422 12891 78748581
Acidosis 211.77 13.87 7 982909 19755 78741717
Medication error 211.21 13.87 324 982592 68318 78693154
Face oedema 209.95 13.87 45 982871 28091 78733381
Circumstance or information capable of leading to medication error 209.46 13.87 251 982665 3697 78757775
Device dislocation 207.68 13.87 35 982881 25935 78735537
Cardiomegaly 205.32 13.87 38 982878 26314 78735158
Device failure 205.26 13.87 315 982601 5946 78755526
Shock haemorrhagic 205.21 13.87 10 982906 20050 78741422
Blood potassium decreased 204.13 13.87 164 982752 46348 78715124
Intestinal obstruction 203.89 13.87 140 982776 42880 78718592
Ear pain 203.23 13.87 874 982042 31995 78729477
Impaired work ability 202.57 13.87 618 982298 19063 78742409
Gastritis 202.28 13.87 176 982740 47817 78713655
Limb operation 202.09 13.87 230 982686 3196 78758276
Rash pruritic 200.43 13.87 1541 981375 70088 78691384
Antibiotic therapy 199.12 13.87 127 982789 732 78760740
Troponin increased 198.91 13.87 9 982907 19246 78742226
Skin discolouration 198.60 13.87 1016 981900 40018 78721454
Off label use 198.50 13.87 9153 973763 898062 77863410
Glossodynia 198.19 13.87 2047 980869 101290 78660182
Hypothyroidism 197.73 13.87 212 982704 52180 78709292
Joint warmth 196.77 13.87 162 982754 1462 78760010
Rubber sensitivity 196.46 13.87 167 982749 1582 78759890
Injection site papule 196.15 13.87 130 982786 808 78760664
Myocarditis 196.01 13.87 20 982896 21713 78739759
Wheezing 195.50 13.87 757 982159 115907 78645565
Myalgia 194.93 13.87 1412 981504 184229 78577243
Skin haemorrhage 193.58 13.87 445 982471 11536 78749936
Blood sodium decreased 189.66 13.87 86 982830 33169 78728303
Drug-induced liver injury 189.46 13.87 327 982589 65790 78695682
Hypoalbuminaemia 188.49 13.87 21 982895 21276 78740196
Ataxia 186.93 13.87 40 982876 24999 78736473
Emotional distress 186.87 13.87 132 982784 39837 78721635
Nephropathy toxic 186.23 13.87 18 982898 20401 78741071
Pruritus 185.93 13.87 6266 976650 388382 78373090
Muscle rigidity 185.43 13.87 16 982900 19866 78741606
Malnutrition 185.18 13.87 28 982888 22474 78738998
Left ventricular dysfunction 184.96 13.87 14 982902 19347 78742125
Discomfort 183.37 13.87 2360 980556 123257 78638215
Myocardial ischaemia 180.15 13.87 46 982870 25473 78735999
Myelodysplastic syndrome 179.74 13.87 74 982842 30227 78731245
Acute coronary syndrome 179.28 13.87 24 982892 21109 78740363
Subarachnoid haemorrhage 178.78 13.87 41 982875 24424 78737048
Full blood count abnormal 178.51 13.87 142 982774 40332 78721140
Mania 177.92 13.87 12 982904 18248 78743224
Atrial flutter 177.75 13.87 27 982889 21598 78739874
Respiratory rate increased 177.48 13.87 27 982889 21573 78739899
Haemodynamic instability 176.74 13.87 9 982907 17373 78744099
Transfusion 174.49 13.87 27 982889 21303 78740169
Furuncle 174.40 13.87 325 982591 7229 78754243
Acute myeloid leukaemia 174.38 13.87 81 982835 30804 78730668
Hallucination, auditory 174.36 13.87 24 982892 20669 78740803
Toxic skin eruption 174.00 13.87 32 982884 22261 78739211
Mydriasis 173.66 13.87 11 982905 17632 78743840
Chronic obstructive pulmonary disease 173.33 13.87 510 982406 84909 78676563
Tricuspid valve incompetence 173.05 13.87 20 982896 19692 78741780
Disturbance in attention 173.01 13.87 223 982693 50578 78710894
Blood pressure diastolic abnormal 172.33 13.87 18 982898 19184 78742288
Acute generalised exanthematous pustulosis 172.12 13.87 10 982906 17244 78744228
Full blood count decreased 171.66 13.87 58 982858 26761 78734711
Speech disorder 170.39 13.87 254 982662 54191 78707281
Treatment noncompliance 170.33 13.87 237 982679 52031 78709441
Demyelination 170.22 13.87 333 982583 7690 78753782
Exostosis 168.52 13.87 524 982392 16334 78745138
Haemodialysis 168.41 13.87 15 982901 18153 78743319
Anaphylactic shock 168.13 13.87 119 982797 35877 78725595
Erythema 167.78 13.87 3766 979150 219524 78541948
Oliguria 167.25 13.87 8 982908 16301 78745171
Supraventricular tachycardia 167.16 13.87 30 982886 21240 78740232
Body temperature decreased 167.03 13.87 94 982822 32051 78729421
Wound 166.75 13.87 2176 980740 114003 78647469
Cholelithiasis 166.47 13.87 244 982672 52420 78709052
Cytopenia 166.29 13.87 26 982890 20357 78741115
Gastroenteritis 165.44 13.87 108 982808 33974 78727498
Joint fluid drainage 165.21 13.87 80 982836 238 78761234
Delusion 164.48 13.87 27 982889 20396 78741076
Anhedonia 164.34 13.87 4 982912 14894 78746578
Parkinsonism 164.26 13.87 10 982906 16574 78744898
Thrombotic microangiopathy 163.92 13.87 26 982890 20143 78741329
Device use error 163.31 13.87 305 982611 6796 78754676
No adverse event 162.14 13.87 132 982784 37060 78724412
Atrioventricular block complete 161.59 13.87 11 982905 16599 78744873
Device related infection 160.67 13.87 113 982803 34181 78727291
Bronchospasm 160.45 13.87 53 982863 24806 78736666
Klebsiella infection 160.28 13.87 8 982908 15712 78745760
Sudden death 160.02 13.87 40 982876 22471 78739001
Mitral valve incompetence 159.61 13.87 76 982840 28489 78732983
Renal injury 159.58 13.87 13 982903 16914 78744558
Immune system disorder 158.06 13.87 391 982525 10638 78750834
Musculoskeletal discomfort 157.88 13.87 571 982345 19264 78742208
Hypovolaemia 157.70 13.87 17 982899 17674 78743798
Aspiration 157.20 13.87 29 982887 20129 78741343
Skin laceration 156.49 13.87 740 982176 28222 78733250
Frequent bowel movements 155.48 13.87 85 982831 29454 78732018
Hypernatraemia 155.27 13.87 5 982911 14446 78747026
Prothrombin time prolonged 153.85 13.87 15 982901 16884 78744588
Diverticulitis 153.83 13.87 1032 981884 44904 78716568
Cardiac failure acute 152.50 13.87 25 982891 18904 78742568
Infusion site pain 151.98 13.87 5 982911 14171 78747301
Haematotoxicity 151.79 13.87 10 982906 15509 78745963
Hepatitis cholestatic 151.74 13.87 4 982912 13848 78747624
Urine output decreased 151.62 13.87 21 982895 18001 78743471
White blood cell count increased 151.14 13.87 446 982470 74187 78687285
Walking aid user 151.00 13.87 365 982551 9783 78751689
Glomerular filtration rate decreased 150.80 13.87 46 982870 22656 78738816
Scratch 150.16 13.87 324 982592 8039 78753433
Product quality issue 149.78 13.87 119 982797 33821 78727651
Eye disorder 149.74 13.87 629 982287 22783 78738689
Hyperthermia 149.45 13.87 22 982894 18015 78743457
Paranoia 149.31 13.87 29 982887 19403 78742069
Lipase increased 148.90 13.87 15 982901 16451 78745021
Bronchopulmonary aspergillosis 148.40 13.87 45 982871 22249 78739223
Red blood cell count decreased 147.59 13.87 304 982612 57209 78704263
Proteinuria 147.19 13.87 111 982805 32391 78729081
Neutrophil count increased 147.02 13.87 90 982826 29306 78732166
Injection site paraesthesia 146.07 13.87 92 982824 517 78760955
Myopathy 145.28 13.87 37 982879 20526 78740946
Drug level decreased 144.73 13.87 8 982908 14394 78747078
Oesophagitis 144.59 13.87 59 982857 24230 78737242
Angina unstable 144.51 13.87 17 982899 16510 78744962
Anaphylactic reaction 143.77 13.87 538 982378 83205 78678267
Aplastic anaemia 143.46 13.87 24 982892 17881 78743591
Clostridium difficile infection 141.65 13.87 191 982725 42494 78718978
Epistaxis 141.15 13.87 801 982115 110714 78650758
Second primary malignancy 141.09 13.87 9 982907 14341 78747131
Blood pressure systolic abnormal 140.70 13.87 22 982894 17225 78744247
Blood loss anaemia 140.46 13.87 14 982902 15484 78745988
Enterocolitis 140.05 13.87 10 982906 14502 78746970
Atelectasis 139.98 13.87 115 982801 32142 78729330
Drug resistance 139.97 13.87 189 982727 42024 78719448
Osteonecrosis 139.79 13.87 107 982809 30988 78730484
Blood potassium increased 139.09 13.87 95 982821 29180 78732292
Heart rate irregular 138.74 13.87 119 982797 32560 78728912
Cardiomyopathy 138.56 13.87 92 982824 28682 78732790
Diabetes mellitus inadequate control 137.98 13.87 63 982853 24201 78737271
Secretion discharge 137.49 13.87 453 982463 14569 78746903
Metastases to bone 136.47 13.87 65 982851 24362 78737110
Cytomegalovirus viraemia 135.78 13.87 5 982911 12816 78748656
Spinal pain 135.40 13.87 458 982458 14934 78746538
Lower gastrointestinal haemorrhage 135.17 13.87 19 982897 16106 78745366
Miosis 133.78 13.87 18 982898 15771 78745701
Toothache 132.80 13.87 543 982373 19427 78742045
Blood magnesium decreased 132.60 13.87 22 982894 16490 78744982
Nightmare 132.40 13.87 77 982839 25784 78735688
Mass 132.37 13.87 495 982421 16977 78744495
Peritonitis 131.85 13.87 92 982824 27944 78733528
Pulseless electrical activity 130.42 13.87 12 982904 14148 78747324
Back disorder 130.03 13.87 375 982541 11203 78750269
Ventricular extrasystoles 128.95 13.87 41 982875 19663 78741809
Hyperthyroidism 128.91 13.87 56 982860 22153 78739319
Activated partial thromboplastin time prolonged 128.56 13.87 13 982903 14215 78747257
Blood lactic acid increased 128.32 13.87 7 982909 12737 78748735
Rheumatoid factor increased 127.88 13.87 134 982782 1687 78759785
Failure to thrive 127.61 13.87 4 982912 11840 78749632
Hydronephrosis 126.05 13.87 30 982886 17424 78744048
Salivary hypersecretion 125.95 13.87 14 982902 14210 78747262
Flatulence 125.45 13.87 208 982708 42516 78718956
Stress 125.28 13.87 1517 981399 78095 78683377
Rales 125.01 13.87 45 982871 19956 78741516
Asthma 124.79 13.87 1064 981852 134031 78627441
Gastroenteritis viral 124.50 13.87 621 982295 24210 78737262
Blood albumin decreased 124.37 13.87 72 982844 24171 78737301
Increased upper airway secretion 124.26 13.87 201 982715 3976 78757496
Hepatitis acute 124.16 13.87 21 982895 15521 78745951
Respiratory acidosis 123.57 13.87 3 982913 11197 78750275
Enterococcal infection 123.26 13.87 22 982894 15638 78745834
Rash erythematous 122.69 13.87 1169 981747 56600 78704872
Complication associated with device 122.62 13.87 32 982884 17464 78744008
Injection site laceration 122.53 13.87 50 982866 83 78761389
Hypoaesthesia 122.39 13.87 2985 979931 176367 78585105
Arteriosclerosis coronary artery 122.19 13.87 34 982882 17782 78743690
Faeces discoloured 121.31 13.87 108 982808 29019 78732453
Pseudomonas infection 120.86 13.87 53 982863 20850 78740622
Urosepsis 120.61 13.87 90 982826 26405 78735067
Haemolytic anaemia 120.38 13.87 35 982881 17785 78743687
Anal incontinence 120.34 13.87 37 982879 18131 78743341
Abdominal pain lower 119.48 13.87 129 982787 31653 78729819
Cyst 119.27 13.87 409 982507 13431 78748041
Incorrect disposal of product 118.81 13.87 98 982818 887 78760585
Hypertransaminasaemia 118.67 13.87 7 982909 11917 78749555
Urticaria 118.57 13.87 3056 979860 182145 78579327
Duodenal ulcer 118.48 13.87 28 982888 16341 78745131
Pustular psoriasis 117.56 13.87 212 982704 4594 78756878
Drug dependence 117.38 13.87 201 982715 40568 78720904
Wrist surgery 117.19 13.87 90 982826 727 78760745
Tooth disorder 116.96 13.87 635 982281 25598 78735874
Hypovolaemic shock 116.92 13.87 9 982907 12267 78749205
Fine motor skill dysfunction 116.89 13.87 225 982691 5132 78756340
Gait inability 116.71 13.87 1175 981741 57742 78703730
Toxic encephalopathy 116.07 13.87 6 982910 11434 78750038
Tardive dyskinesia 115.99 13.87 3 982913 10568 78750904
Acute pulmonary oedema 114.18 13.87 19 982897 14211 78747261
Polyuria 114.11 13.87 23 982893 14991 78746481
Asphyxia 113.32 13.87 8 982908 11712 78749760
Pathogen resistance 113.21 13.87 20 982896 14322 78747150
Eosinophil count increased 113.00 13.87 35 982881 17070 78744402
Granulocytopenia 112.89 13.87 7 982909 11424 78750048
Depression 112.85 13.87 1935 980981 214855 78546617
Kidney infection 112.77 13.87 551 982365 21300 78740172
Irritable bowel syndrome 112.76 13.87 1219 981697 61022 78700450
Ankle operation 112.09 13.87 99 982817 992 78760480
Substance abuse 111.83 13.87 4 982912 10522 78750950
Erythema multiforme 111.54 13.87 39 982877 17612 78743860
Dialysis 111.28 13.87 44 982872 18418 78743054
Meniscus injury 111.14 13.87 253 982663 6515 78754957
Lower respiratory tract infection 111.09 13.87 2223 980693 126997 78634475
Electrocardiogram abnormal 111.01 13.87 34 982882 16703 78744769
Viral upper respiratory tract infection 110.86 13.87 302 982614 8724 78752748
End stage renal disease 110.85 13.87 11 982905 12209 78749263
Bundle branch block right 110.78 13.87 7 982909 11244 78750228
Dysgeusia 109.85 13.87 350 982566 56827 78704645
Metastases to liver 109.73 13.87 112 982804 28202 78733270
Uveitis 109.06 13.87 454 982462 16376 78745096
Vascular device infection 108.85 13.87 4 982912 10272 78751200
Macule 108.73 13.87 157 982759 2800 78758672
Pericarditis 108.71 13.87 1848 981068 102388 78659084
Faecaloma 108.68 13.87 9 982907 11555 78749917
Pneumothorax 108.67 13.87 113 982803 28210 78733262
Aspergillus infection 108.57 13.87 50 982866 19111 78742361
Iridocyclitis 108.51 13.87 177 982739 3527 78757945
Interstitial lung disease 108.45 13.87 877 982039 111723 78649749
Arthrodesis 108.45 13.87 141 982775 2266 78759206
Polyneuropathy 107.43 13.87 84 982832 24067 78737405
Poor venous access 106.55 13.87 45 982871 18104 78743368
Immune thrombocytopenia 106.39 13.87 43 982873 17762 78743710
Haemophagocytic lymphohistiocytosis 106.26 13.87 69 982847 21768 78739704
Hyperhidrosis 106.00 13.87 1275 981641 150217 78611255
Muscle injury 105.78 13.87 988 981928 47573 78713899
Diastolic dysfunction 105.64 13.87 7 982909 10804 78750668
Apnoea 104.96 13.87 11 982905 11693 78749779
Therapeutic response delayed 104.31 13.87 97 982819 1045 78760427
Infusion site extravasation 103.52 13.87 5 982911 10103 78751369
Taste disorder 103.42 13.87 33 982883 15790 78745682
Hypertensive crisis 103.30 13.87 64 982852 20706 78740766
Fatigue 103.22 13.87 13022 969894 916705 77844767
Blood phosphorus increased 103.20 13.87 6 982910 10341 78751131
Jaundice cholestatic 102.77 13.87 10 982906 11274 78750198
Hypoacusis 102.54 13.87 680 982236 29470 78732002
Chromaturia 101.88 13.87 100 982816 25646 78735826
Laryngitis 101.86 13.87 430 982486 15609 78745863
Psychomotor hyperactivity 101.81 13.87 40 982876 16809 78744663
Hip surgery 101.45 13.87 160 982756 3095 78758377
Helicobacter infection 101.44 13.87 1309 981607 68395 78693077
Upper respiratory tract congestion 101.31 13.87 142 982774 2461 78759011
Hyperuricaemia 101.05 13.87 13 982903 11786 78749686
Irritability 100.96 13.87 223 982693 40921 78720551
Ventricular hypokinesia 100.46 13.87 3 982913 9276 78752196
Lip swelling 100.17 13.87 222 982694 40689 78720783
Hypertriglyceridaemia 100.05 13.87 18 982898 12722 78748750
Dermatitis atopic 99.79 13.87 6 982910 10050 78751422
Arteriosclerosis 99.55 13.87 50 982866 18177 78743295
Amylase increased 99.33 13.87 11 982905 11198 78750274
Skin mass 99.25 13.87 270 982646 7793 78753679
Cholecystitis 99.13 13.87 77 982839 22135 78739337
Infusion site erythema 99.12 13.87 4 982912 9456 78752016
Limb deformity 99.06 13.87 167 982749 3423 78758049
Haemorrhoids 99.04 13.87 128 982788 29000 78732472
Neck surgery 98.73 13.87 117 982799 1702 78759770
Atrioventricular block 97.79 13.87 26 982890 14015 78747457
Colitis ulcerative 97.55 13.87 174 982742 34568 78726904
Pulse absent 97.39 13.87 7 982909 10096 78751376
Colitis ischaemic 96.95 13.87 34 982882 15325 78746147
Peripheral sensory neuropathy 96.93 13.87 21 982895 13012 78748460
Ankylosing spondylitis 96.84 13.87 351 982565 11854 78749618
Cataract operation 96.69 13.87 204 982712 4981 78756491
Lung infiltration 96.58 13.87 84 982832 22828 78738644
Pemphigoid 96.50 13.87 34 982882 15281 78746191
Thrombosis 96.49 13.87 623 982293 83477 78677995
Rheumatoid factor negative 96.43 13.87 94 982822 1079 78760393
Folliculitis 96.36 13.87 1076 981840 54304 78707168
Systemic infection 96.22 13.87 6 982910 9746 78751726
Schizophrenia 96.06 13.87 35 982881 15405 78746067
Cardiac failure chronic 96.01 13.87 12 982904 11123 78750349
Apparent death 95.13 13.87 145 982771 2720 78758752
Nail disorder 95.02 13.87 342 982574 11510 78749962
Haemorrhagic stroke 95.01 13.87 12 982904 11034 78750438
Intervertebral disc protrusion 94.88 13.87 556 982360 23065 78738407
Hepatic necrosis 94.84 13.87 4 982912 9096 78752376
Ankle deformity 94.69 13.87 75 982841 637 78760835
Deformity 94.57 13.87 297 982619 9308 78752164
Haemolysis 94.56 13.87 21 982895 12791 78748681
Pulmonary haemorrhage 93.89 13.87 32 982884 14685 78746787
Drug level below therapeutic 93.51 13.87 7 982909 9763 78751709
Chills 93.44 13.87 1400 981516 158834 78602638
Drug tolerance decreased 92.81 13.87 361 982555 12617 78748855
Gallbladder operation 92.76 13.87 119 982797 1886 78759586
Influenza like illness 92.60 13.87 1318 981598 70389 78691083
Graft versus host disease 91.91 13.87 35 982881 14991 78746481
Intestinal ischaemia 91.62 13.87 25 982891 13245 78748227
Hemiplegia 91.04 13.87 35 982881 14904 78746568
Metastases to central nervous system 90.83 13.87 44 982872 16331 78745141
Premature delivery 90.74 13.87 93 982823 23374 78738098
Appendicitis 90.39 13.87 74 982842 20720 78740752
Bone disorder 90.23 13.87 470 982446 18643 78742829
Throat irritation 90.16 13.87 835 982081 40111 78721361
Blood triglycerides increased 90.07 13.87 76 982840 20964 78740508
Elbow deformity 89.80 13.87 103 982813 1444 78760028
Cerebral ischaemia 89.71 13.87 15 982901 11180 78750292
Left ventricular hypertrophy 89.67 13.87 15 982901 11176 78750296
Cholecystitis chronic 89.64 13.87 9 982907 9897 78751575
Tooth abscess 89.64 13.87 417 982499 15793 78745679
Tooth extraction 89.62 13.87 319 982597 10676 78750796
Blister 89.62 13.87 2015 980901 117461 78644011
Animal bite 89.54 13.87 136 982780 2543 78758929
Swollen tongue 89.40 13.87 250 982666 42320 78719152
Stress cardiomyopathy 89.39 13.87 15 982901 11151 78750321
Metabolic encephalopathy 89.15 13.87 6 982910 9141 78752331
Feeling hot 89.13 13.87 1127 981789 58607 78702865
Ecchymosis 88.80 13.87 38 982878 15168 78746304
Guttate psoriasis 88.75 13.87 61 982855 406 78761066
Peritonitis bacterial 88.40 13.87 8 982908 9559 78751913
Hyperlipidaemia 88.37 13.87 115 982801 25978 78735494
Paraesthesia oral 87.57 13.87 74 982842 20397 78741075
Skin ulcer 87.45 13.87 1037 981879 53113 78708359
Carpal tunnel decompression 86.96 13.87 70 982846 610 78760862
General symptom 86.62 13.87 130 982786 2404 78759068
Duodenal ulcer perforation 85.50 13.87 1217 981699 64994 78696478
Nocturia 85.13 13.87 31 982885 13650 78747822
Diplopia 84.93 13.87 178 982738 33288 78728184
Rash papular 84.90 13.87 511 982405 21405 78740067
Bundle branch block left 84.71 13.87 19 982897 11494 78749978
Hospice care 84.60 13.87 13 982903 10311 78751161
Endodontic procedure 84.35 13.87 134 982782 2609 78758863
Partial seizures 84.34 13.87 7 982909 8971 78752501
Hypercapnia 83.85 13.87 7 982909 8928 78752544
Sleep apnoea syndrome 83.65 13.87 205 982711 36273 78725199
Bradyphrenia 83.63 13.87 15 982901 10625 78750847
Tooth fracture 83.50 13.87 322 982594 11208 78750264
Ketoacidosis 83.39 13.87 3 982913 7851 78753621
Oral surgery 83.24 13.87 85 982831 1036 78760436
Enthesopathy 83.10 13.87 323 982593 11285 78750187
Ageusia 83.06 13.87 51 982865 16581 78744891
Forced expiratory volume decreased 82.91 13.87 3 982913 7811 78753661
Hypogammaglobulinaemia 82.90 13.87 28 982888 12923 78748549
Decubitus ulcer 82.76 13.87 45 982871 15642 78745830
Device occlusion 82.59 13.87 22 982894 11844 78749628
Dermatitis bullous 82.55 13.87 36 982880 14209 78747263
Gastrointestinal disorder 82.46 13.87 2031 980885 120174 78641298
Hepatotoxicity 82.33 13.87 339 982577 51013 78710459
Systemic inflammatory response syndrome 82.22 13.87 20 982896 11445 78750027
Cachexia 82.13 13.87 18 982898 11065 78750407
Bronchitis chronic 82.03 13.87 175 982741 4307 78757165
Azotaemia 81.94 13.87 5 982911 8271 78753201
Dysuria 81.91 13.87 336 982580 50615 78710857
Rotator cuff repair 81.86 13.87 108 982808 1762 78759710
Mental disorder 81.54 13.87 164 982752 31138 78730334
Cystitis haemorrhagic 81.28 13.87 9 982907 9163 78752309
Petechiae 81.24 13.87 80 982836 20485 78740987
Rotator cuff syndrome 81.21 13.87 367 982549 13728 78747744
Hepatomegaly 81.01 13.87 68 982848 18806 78742666
Metastases to lung 81.01 13.87 63 982853 18100 78743372
Onychomycosis 80.93 13.87 255 982661 8006 78753466
Coma scale abnormal 80.88 13.87 7 982909 8671 78752801
Toe operation 80.49 13.87 63 982853 525 78760947
Pulmonary alveolar haemorrhage 80.20 13.87 21 982895 11436 78750036
Myositis 79.92 13.87 71 982845 19097 78742375
Surgical failure 79.74 13.87 74 982842 795 78760677
Hypoxic-ischaemic encephalopathy 79.66 13.87 4 982912 7816 78753656
Vision blurred 79.62 13.87 877 982039 105021 78656451
Pneumonia fungal 79.52 13.87 20 982896 11190 78750282
Blood pressure diastolic increased 79.26 13.87 40 982876 14502 78746970
Iron deficiency anaemia 79.13 13.87 121 982795 25551 78735921
Wrist deformity 78.72 13.87 113 982803 2004 78759468
Incontinence 78.65 13.87 38 982878 14126 78747346
Cerebral haematoma 78.02 13.87 5 982911 7937 78753535
Sickle cell anaemia with crisis 77.79 13.87 5 982911 7917 78753555
Gastritis erosive 77.63 13.87 19 982897 10828 78750644
C-reactive protein increased 77.62 13.87 2112 980804 126915 78634557
Hyperreflexia 77.51 13.87 7 982909 8378 78753094
Dental operation 77.16 13.87 83 982833 1079 78760393
Ileus paralytic 76.84 13.87 13 982903 9607 78751865
Elbow operation 76.82 13.87 51 982865 318 78761154
Pneumocystis jirovecii pneumonia 76.67 13.87 180 982736 32328 78729144
Oral mucosal exfoliation 76.48 13.87 93 982823 1392 78760080
Panniculitis 75.73 13.87 328 982588 12043 78749429
Pneumonia bacterial 75.44 13.87 76 982840 19255 78742217
Product complaint 75.37 13.87 35 982881 13314 78748158
Gastric haemorrhage 75.37 13.87 46 982870 15004 78746468
Head injury 75.15 13.87 224 982692 37145 78724327
Burning sensation 75.03 13.87 1076 981840 57556 78703916
Physical disability 75.02 13.87 141 982775 3157 78758315
Coronary artery stenosis 74.84 13.87 30 982886 12454 78749018
Atrial tachycardia 74.79 13.87 3 982913 7130 78754342
Tenderness 74.32 13.87 523 982393 23119 78738353
Skin toxicity 74.08 13.87 8 982908 8306 78753166
Cardiac disorder 73.97 13.87 490 982426 65267 78696205
Injection site hypoaesthesia 73.85 13.87 58 982858 486 78760986
Hypotonia 73.83 13.87 33 982883 12837 78748635
SLE arthritis 73.62 13.87 60 982856 533 78760939
Aplasia pure red cell 73.62 13.87 6 982910 7804 78753668
Gastric ulcer 73.53 13.87 196 982720 33709 78727763
Scab 73.12 13.87 291 982625 10281 78751191
Cholangitis 72.91 13.87 33 982883 12743 78748729
Skin fissures 72.80 13.87 337 982579 12736 78748736
Vertigo 72.66 13.87 525 982391 68557 78692915
Hypoventilation 72.63 13.87 4 982912 7220 78754252
Eye operation 72.07 13.87 111 982805 2102 78759370
Blood parathyroid hormone decreased 72.06 13.87 289 982627 10247 78751225
Pyelonephritis 72.03 13.87 87 982829 20301 78741171
Hallucinations, mixed 72.01 13.87 3 982913 6896 78754576
Synovial cyst 72 13.87 280 982636 9785 78751687
Iron deficiency 71.83 13.87 21 982895 10633 78750839
Cholecystitis acute 71.82 13.87 38 982878 13413 78748059
Protein urine present 71.81 13.87 18 982898 10094 78751378
Apathy 71.78 13.87 35 982881 12942 78748530
International normalised ratio decreased 71.31 13.87 8 982908 8062 78753410
Granuloma skin 71.24 13.87 262 982654 8912 78752560
Rhinitis allergic 71.11 13.87 31 982885 12238 78749234
Infusion site swelling 71.10 13.87 7 982909 7819 78753653
Enteritis 71.06 13.87 46 982870 14537 78746935
Dyspnoea at rest 70.56 13.87 5 982911 7297 78754175
Acute graft versus host disease 70.48 13.87 19 982897 10148 78751324
Carpal tunnel syndrome 70.42 13.87 447 982469 19081 78742391
Hepatitis fulminant 70.09 13.87 5 982911 7257 78754215
Vulvovaginal mycotic infection 69.84 13.87 166 982750 4400 78757072
Nephropathy 69.81 13.87 17 982899 9721 78751751
Device dispensing error 69.78 13.87 35 982881 115 78761357
Ischaemic cardiomyopathy 69.61 13.87 7 982909 7688 78753784
Lung consolidation 69.49 13.87 13 982903 8934 78752538
Purpura 69.33 13.87 83 982833 19444 78742028
Concomitant disease aggravated 69.13 13.87 38 982878 13129 78748343
Cytomegalovirus infection reactivation 69.13 13.87 12 982904 8704 78752768
Bone swelling 68.95 13.87 95 982821 1619 78759853
Cardiac tamponade 68.87 13.87 15 982901 9261 78752211
Brain injury 68.51 13.87 28 982888 11489 78749983
Fistula 68.44 13.87 37 982879 12903 78748569
Tinnitus 68.39 13.87 297 982619 44036 78717436
Embolism 68.28 13.87 44 982872 13938 78747534
Respiratory syncytial virus infection 68.21 13.87 16 982900 9386 78752086
Clonus 68.12 13.87 4 982912 6836 78754636
Tuberculosis 67.83 13.87 368 982548 14830 78746642
Metabolic disorder 67.74 13.87 15 982901 9155 78752317
Blood chloride decreased 67.69 13.87 10 982906 8167 78753305
Tenosynovitis 67.66 13.87 374 982542 15180 78746292
Joint dislocation 67.57 13.87 398 982518 16541 78744931
Dyspepsia 67.42 13.87 938 981978 107749 78653723
Wheelchair user 67.31 13.87 197 982719 5935 78755537
Hiccups 67.21 13.87 20 982896 10011 78751461
Rheumatoid arthritis 67.13 13.87 3178 979738 205292 78556180
Pulmonary fibrosis 66.98 13.87 835 982081 43277 78718195
Hypertonia 66.95 13.87 6 982910 7226 78754246
Eye infection 66.91 13.87 308 982608 11612 78749860
Proctalgia 66.90 13.87 20 982896 9981 78751491
Muscular weakness 66.76 13.87 1490 981426 159239 78602233
Tachyarrhythmia 66.60 13.87 5 982911 6957 78754515
Sciatica 66.48 13.87 664 982252 32558 78728914
Sarcoidosis 66.38 13.87 240 982676 8095 78753377
Skin disorder 66.28 13.87 675 982241 33268 78728204
Latent tuberculosis 66.14 13.87 135 982781 3218 78758254
Pneumatosis intestinalis 66.05 13.87 3 982913 6394 78755078
Injection site coldness 65.89 13.87 32 982884 96 78761376
Hyperphosphataemia 65.80 13.87 3 982913 6373 78755099
Splenomegaly 65.74 13.87 96 982820 20658 78740814
Complication of device insertion 65.49 13.87 3 982913 6347 78755125
Erectile dysfunction 65.23 13.87 51 982865 14613 78746859
Behaviour disorder 65.05 13.87 3 982913 6310 78755162
Lymphoma 65.04 13.87 403 982513 17057 78744415
Brain natriuretic peptide increased 64.86 13.87 15 982901 8885 78752587
Neoplasm malignant 64.73 13.87 638 982278 31172 78730300
Incorrect product administration duration 64.14 13.87 34 982882 11988 78749484
Memory impairment 64.13 13.87 1818 981098 109916 78651556
Wrong product administered 64.08 13.87 16 982900 8996 78752476
Blood culture positive 63.88 13.87 13 982903 8416 78753056
Induration 63.70 13.87 98 982818 1854 78759618
Clostridium test positive 63.59 13.87 4 982912 6450 78755022
Endophthalmitis 63.29 13.87 4 982912 6424 78755048
Benign prostatic hyperplasia 63.20 13.87 32 982884 11580 78749892
Blood phosphorus decreased 63.19 13.87 5 982911 6663 78754809
Blood pressure systolic decreased 62.60 13.87 29 982887 11047 78750425
Orthopnoea 62.38 13.87 23 982893 10050 78751422
Post procedural haemorrhage 62.15 13.87 47 982869 13697 78747775
Ischaemia 62.15 13.87 12 982904 8063 78753409
Thirst 62.09 13.87 83 982833 18536 78742936
Eczema 62.03 13.87 275 982641 40543 78720929
Escherichia bacteraemia 61.97 13.87 5 982911 6557 78754915
Muscle haemorrhage 61.79 13.87 4 982912 6296 78755176
Post procedural infection 61.59 13.87 291 982625 11093 78750379
Aplasia 61.52 13.87 11 982905 7809 78753663
Joint surgery 61.41 13.87 42 982874 277 78761195
Peripheral ischaemia 61.32 13.87 20 982896 9437 78752035
Renal tubular disorder 61.09 13.87 5 982911 6481 78754991
Duodenal ulcer haemorrhage 61.08 13.87 8 982908 7155 78754317
Ventricular hypertrophy 61 13.87 7 982909 6931 78754541
Weight fluctuation 60.86 13.87 34 982882 11641 78749831
Intracranial pressure increased 60.70 13.87 14 982902 8308 78753164
Nystagmus 60.69 13.87 23 982893 9881 78751591
Nerve injury 60.58 13.87 253 982663 9139 78752333
Oral herpes 60.51 13.87 560 982356 26894 78734578
Depressive symptom 60.36 13.87 5 982911 6418 78755054
Weight increased 60.16 13.87 2799 980117 274587 78486885
Dry eye 59.96 13.87 708 982208 36223 78725249
Intestinal perforation 59.84 13.87 76 982840 17350 78744122
Injection site oedema 59.74 13.87 79 982837 1292 78760180
Large intestine perforation 59.49 13.87 55 982861 14512 78746960
Red cell distribution width increased 59.39 13.87 60 982856 15182 78746290
Catheter site infection 59.38 13.87 7 982909 6788 78754684
Aortic arteriosclerosis 59.36 13.87 18 982898 8900 78752572
Protein total decreased 59.35 13.87 19 982897 9073 78752399
Skin exfoliation 59.31 13.87 982 981934 54118 78707354
Osteoporosis 59.21 13.87 967 981949 53145 78708327
Device power source issue 59.11 13.87 66 982850 897 78760575
Odynophagia 59.02 13.87 33 982883 11294 78750178
Candida infection 58.95 13.87 256 982660 37958 78723514
Aortic valve incompetence 58.62 13.87 22 982894 9508 78751964
Non-cardiac chest pain 58.56 13.87 22 982894 9502 78751970
Cardiovascular disorder 58.45 13.87 82 982834 17943 78743529
Systemic candida 58.38 13.87 7 982909 6699 78754773
Nerve compression 58.13 13.87 247 982669 8992 78752480
Tendon operation 58.02 13.87 39 982877 249 78761223
Bunion operation 58.01 13.87 65 982851 887 78760585
Occult blood positive 57.95 13.87 8 982908 6875 78754597
Gynaecomastia 57.89 13.87 12 982904 7669 78753803
Normal newborn 57.74 13.87 9 982907 7063 78754409
Injection site dryness 57.73 13.87 43 982873 330 78761142
Infection susceptibility increased 57.70 13.87 136 982780 3585 78757887
Cardiac murmur 57.54 13.87 66 982850 15758 78745714
Hiatus hernia 57.48 13.87 126 982790 23186 78738286
Pulmonary function test decreased 57.42 13.87 12 982904 7625 78753847
Ammonia increased 57.40 13.87 12 982904 7623 78753849
Bone cyst 57.11 13.87 129 982787 3304 78758168
Dental implantation 56.97 13.87 51 982865 521 78760951
Serum ferritin increased 56.88 13.87 25 982891 9822 78751650
Supraventricular extrasystoles 56.80 13.87 9 982907 6978 78754494
Hyperlactacidaemia 56.56 13.87 3 982913 5592 78755880
Lip oedema 56.47 13.87 6 982910 6310 78755162
Escherichia infection 56.42 13.87 84 982832 17933 78743539
Euphoric mood 56.35 13.87 13 982903 7713 78753759
Middle insomnia 56.31 13.87 69 982847 16000 78745472
Dyslipidaemia 56.27 13.87 37 982879 11596 78749876
Venous thrombosis 56.00 13.87 10 982906 7106 78754366
Foetal exposure during pregnancy 55.84 13.87 4 982912 5786 78755686
Orthosis user 55.71 13.87 24 982892 49 78761423
Hydrocephalus 55.66 13.87 20 982896 8880 78752592
Blood thyroid stimulating hormone increased 55.52 13.87 25 982891 9683 78751789
Thyroid neoplasm 55.01 13.87 121 982795 3043 78758429
Arthropod sting 54.89 13.87 74 982842 1234 78760238
Pseudomonal sepsis 54.86 13.87 6 982910 6168 78755304
Neutrophilia 54.85 13.87 15 982901 7936 78753536
Mucormycosis 54.75 13.87 18 982898 8451 78753021
BK virus infection 54.70 13.87 20 982896 8784 78752688
Infusion related reaction 54.68 13.87 2300 980616 227937 78533535
Mental impairment 54.66 13.87 94 982822 18942 78742530
Therapy partial responder 54.58 13.87 81 982835 17316 78744156
Personality disorder 54.54 13.87 6 982910 6140 78755332
Sensitivity to weather change 54.45 13.87 220 982696 7827 78753645
Injection site scar 54.43 13.87 59 982857 774 78760698
Joint laxity 54.30 13.87 101 982815 2243 78759229
Cerebral atrophy 54.29 13.87 16 982900 8059 78753413
Catheter site pain 54.22 13.87 3 982913 5393 78756079
Sinus node dysfunction 54.13 13.87 14 982902 7687 78753785
Rheumatoid lung 54.11 13.87 144 982772 4101 78757371
Electrocardiogram T wave inversion 53.93 13.87 3 982913 5369 78756103
Dementia 53.89 13.87 142 982774 24517 78736955
Papule 53.75 13.87 207 982709 7200 78754272
Product substitution issue 53.73 13.87 105 982811 20151 78741321
Gastric ulcer haemorrhage 53.61 13.87 22 982894 9005 78752467
Nail pitting 53.57 13.87 43 982873 373 78761099
Embolic stroke 53.55 13.87 15 982901 7811 78753661
Malignant melanoma 53.51 13.87 338 982578 14403 78747069
Genital haemorrhage 53.31 13.87 7 982909 6248 78755224
Fibrin D dimer increased 53.19 13.87 20 982896 8634 78752838
Methaemoglobinaemia 53.14 13.87 4 982912 5553 78755919
Rebound effect 53.02 13.87 12 982904 7214 78754258
Dermatitis exfoliative 52.98 13.87 34 982882 10795 78750677
Proctitis 52.93 13.87 8 982908 6424 78755048
Injection site exfoliation 52.48 13.87 37 982879 258 78761214
Retinal haemorrhage 52.19 13.87 18 982898 8199 78753273
Obsessive-compulsive disorder 52.06 13.87 6 982910 5921 78755551
Systemic lupus erythematosus rash 51.95 13.87 87 982829 1773 78759699
Stridor 51.93 13.87 4 982912 5449 78756023
Lower limb fracture 51.90 13.87 475 982441 22740 78738732
Eye movement disorder 51.84 13.87 17 982899 7994 78753478
Product administration error 51.82 13.87 209 982707 31637 78729835
Thrombosis in device 51.80 13.87 4 982912 5438 78756034
Abortion induced 51.77 13.87 12 982904 7097 78754375
Paranasal sinus discomfort 51.67 13.87 146 982770 4310 78757162
Human antichimeric antibody positive 51.61 13.87 81 982835 1560 78759912
Bedridden 51.58 13.87 289 982627 11790 78749682
Affect lability 51.56 13.87 38 982878 11221 78750251
Onychomadesis 51.53 13.87 162 982754 5080 78756392
Dental care 51.41 13.87 60 982856 858 78760614
Hepatitis 51.39 13.87 439 982477 55288 78706184
Laryngeal oedema 51.30 13.87 18 982898 8111 78753361
Rhinovirus infection 51.25 13.87 17 982899 7936 78753536
Staphylococcal bacteraemia 51.25 13.87 45 982871 12173 78749299
Immune reconstitution inflammatory syndrome 51.12 13.87 57 982859 13784 78747688
Alcohol abuse 50.89 13.87 4 982912 5359 78756113
Glaucoma 50.80 13.87 417 982499 19344 78742128
Musculoskeletal deformity 50.61 13.87 78 982838 1478 78759994
Necrosis 50.42 13.87 27 982889 9466 78752006
Eosinophilic pneumonia 50.27 13.87 4 982912 5306 78756166
Nasal polyps 50.22 13.87 14 982902 7313 78754159
Major depression 50.00 13.87 24 982892 8956 78752516
Device defective 49.93 13.87 87 982829 1833 78759639
Knee deformity 49.86 13.87 70 982846 1215 78760257
Cytomegalovirus test positive 49.86 13.87 7 982909 5940 78755532
Gastrointestinal perforation 49.67 13.87 8 982908 6129 78755343
Progressive multifocal leukoencephalopathy 49.44 13.87 113 982803 20487 78740985
Diabetes insipidus 49.43 13.87 4 982912 5233 78756239
Bone graft 49.27 13.87 53 982863 689 78760783
Nervousness 49.23 13.87 629 982287 32786 78728686
Hyperpyrexia 49.18 13.87 8 982908 6084 78755388
Blood immunoglobulin E increased 49.14 13.87 7 982909 5875 78755597
Atlantoaxial instability 49.09 13.87 36 982880 269 78761203
Electroencephalogram abnormal 49.01 13.87 5 982911 5429 78756043
Night sweats 48.75 13.87 908 982008 51187 78710285
Oesophageal ulcer 48.42 13.87 13 982903 6962 78754510
Glycosylated haemoglobin increased 48.40 13.87 103 982813 19157 78742315
Central nervous system lesion 48.34 13.87 56 982860 13312 78748160
Chronic graft versus host disease 48.29 13.87 12 982904 6769 78754703
Polyarthritis 48.22 13.87 286 982630 11916 78749556
Stress at work 48.12 13.87 65 982851 1086 78760386
Upper-airway cough syndrome 48.11 13.87 277 982639 11416 78750056
Bronchiectasis 48.10 13.87 130 982786 22256 78739216
Abdominal wall haematoma 48.08 13.87 3 982913 4870 78756602
Portal hypertension 47.94 13.87 14 982902 7094 78754378
Fungal infection 47.91 13.87 752 982164 40996 78720476
Respiration abnormal 47.87 13.87 18 982898 7770 78753702
Ear congestion 47.80 13.87 109 982807 2810 78758662
Escherichia urinary tract infection 47.78 13.87 60 982856 13765 78747707
Arteriospasm coronary 47.61 13.87 12 982904 6704 78754768
Immune-mediated enterocolitis 47.57 13.87 3 982913 4827 78756645
Alcohol poisoning 47.47 13.87 3 982913 4818 78756654
Drooling 47.44 13.87 8 982908 5926 78755546
Lupus-like syndrome 47.40 13.87 313 982603 13544 78747928
Injection site pustule 47.36 13.87 23 982893 69 78761403
Normochromic normocytic anaemia 47.26 13.87 18 982898 7709 78753763
Ligament rupture 47.24 13.87 119 982797 3275 78758197
Transplant rejection 47.22 13.87 405 982511 19032 78742440
Cytomegalovirus chorioretinitis 47.13 13.87 6 982910 5484 78755988
Fluid intake reduced 47.03 13.87 10 982906 6278 78755194
Left ventricular failure 46.99 13.87 30 982886 9551 78751921
Hysterectomy 46.93 13.87 177 982739 6095 78755377
Colorectal cancer 46.80 13.87 24 982892 8623 78752849
Renal cyst 46.80 13.87 68 982848 14664 78746808
Platelet count increased 46.74 13.87 132 982784 22274 78739198
Bursitis 46.73 13.87 660 982256 35184 78726288
Drug screen positive 46.68 13.87 9 982907 6054 78755418
Femoral neck fracture 46.63 13.87 33 982883 9951 78751521
Oxygen consumption increased 46.45 13.87 4 982912 4975 78756497
Spinal instability 46.41 13.87 41 982875 411 78761061
Ventricular dysfunction 46.25 13.87 9 982907 6014 78755458
Renal disorder 46.23 13.87 316 982600 41789 78719683
Intervertebral disc operation 46.22 13.87 58 982858 898 78760574
Spinal disorder 46.17 13.87 249 982667 10011 78751461
Disease recurrence 46.00 13.87 336 982580 43773 78717699
Spinal stenosis 45.99 13.87 343 982573 15448 78746024
Intentional dose omission 45.97 13.87 223 982693 8594 78752878
Periorbital oedema 45.96 13.87 23 982893 8379 78753093
Skin injury 45.93 13.87 118 982798 3288 78758184
Neutrophil percentage increased 45.92 13.87 3 982913 4686 78756786
Blood pressure inadequately controlled 45.84 13.87 10 982906 6167 78755305
Blood creatine increased 45.83 13.87 30 982886 9425 78752047
Body height below normal 45.74 13.87 87 982829 1966 78759506
Personality change 45.71 13.87 35 982881 10135 78751337
Persecutory delusion 45.64 13.87 4 982912 4905 78756567
International normalised ratio abnormal 45.62 13.87 8 982908 5760 78755712
Self-medication 45.57 13.87 5 982911 5127 78756345
Rash morbilliform 45.55 13.87 10 982906 6140 78755332
Mineral metabolism disorder 45.45 13.87 35 982881 284 78761188
Faecal calprotectin increased 45.35 13.87 7 982909 5534 78755938
Ulcer 45.35 13.87 567 982349 29405 78732067
Application site erythema 45.32 13.87 5 982911 5105 78756367
Incoherent 45.27 13.87 19 982897 7673 78753799
Congestive cardiomyopathy 45.19 13.87 47 982869 11733 78749739
Petit mal epilepsy 45.17 13.87 8 982908 5719 78755753
Performance status decreased 45.16 13.87 10 982906 6103 78755369
Scleritis 45.03 13.87 137 982779 4219 78757253
Carotid artery stenosis 44.94 13.87 26 982890 8732 78752740
Duodenitis 44.81 13.87 21 982895 7946 78753526
Rash macular 44.29 13.87 548 982368 28351 78733121
Blood uric acid increased 44.10 13.87 60 982856 13300 78748172
Thrombotic thrombocytopenic purpura 44.04 13.87 12 982904 6364 78755108
Breath sounds abnormal 44.03 13.87 81 982835 15903 78745569
Multiple-drug resistance 44.00 13.87 27 982889 8781 78752691
Hypoglycaemic coma 43.93 13.87 4 982912 4756 78756716
Prostatic specific antigen increased 43.87 13.87 38 982878 10348 78751124
Atypical femur fracture 43.76 13.87 6 982910 5183 78756289
Disturbance in social behaviour 43.73 13.87 5 982911 4965 78756507
Pneumonia cytomegaloviral 43.72 13.87 5 982911 4964 78756508
Exercise tolerance decreased 43.68 13.87 29 982887 9042 78752430
Exposure to communicable disease 43.61 13.87 43 982873 501 78760971
Lung opacity 43.59 13.87 6 982910 5168 78756304
Diverticulum intestinal 43.51 13.87 26 982890 8579 78752893
Blood chloride increased 43.39 13.87 6 982910 5150 78756322
Mass excision 43.37 13.87 36 982880 329 78761143
Foot fracture 43.34 13.87 438 982478 21543 78739929
Depressed mood 43.33 13.87 385 982531 48095 78713377
Cystitis 43.25 13.87 901 982015 51831 78709641
Laryngeal pain 43.19 13.87 11 982905 6103 78755369
Coordination abnormal 43.16 13.87 93 982823 17219 78744253
Product dose omission in error 43.08 13.87 21 982895 7767 78753705
Oral candidiasis 43.00 13.87 203 982713 29425 78732047
Intraventricular haemorrhage 42.79 13.87 5 982911 4882 78756590
Compartment syndrome 42.57 13.87 6 982910 5076 78756396
Nocardiosis 42.54 13.87 9 982907 5670 78755802
Scar 42.53 13.87 327 982589 14869 78746603
Conjunctival haemorrhage 42.51 13.87 10 982906 5855 78755617
Haemothorax 42.46 13.87 8 982908 5470 78756002
Inadequate analgesia 42.43 13.87 4 982912 4625 78756847
Subileus 42.27 13.87 9 982907 5645 78755827
Neurological decompensation 42.18 13.87 7 982909 5246 78756226
Logorrhoea 42.14 13.87 3 982913 4362 78757110
Spider vein 41.68 13.87 30 982886 217 78761255
Anaemia macrocytic 41.66 13.87 9 982907 5588 78755884
Blood calcium increased 41.61 13.87 40 982876 10360 78751112
Sacroiliitis 41.59 13.87 121 982795 3633 78757839
Colonoscopy 41.53 13.87 81 982835 1866 78759606
Staphylococcus test positive 41.51 13.87 14 982902 6467 78755005
Leukoencephalopathy 41.46 13.87 23 982893 7906 78753566
Lymphocyte percentage decreased 41.39 13.87 6 982910 4970 78756502
Hernia repair 41.38 13.87 84 982832 1994 78759478
Encephalitis 41.37 13.87 74 982842 14686 78746786
Cardiac operation 41.35 13.87 146 982770 4866 78756606
Gastrointestinal necrosis 41.32 13.87 9 982907 5556 78755916
Nephrotic syndrome 41.29 13.87 46 982870 11128 78750344
Product administered at inappropriate site 41.26 13.87 125 982791 3840 78757632
Rheumatic fever 41.20 13.87 535 982381 27990 78733482
Bilirubin conjugated increased 41.04 13.87 9 982907 5530 78755942
Somnambulism 40.99 13.87 10 982906 5711 78755761
Gastric disorder 40.97 13.87 669 982247 36764 78724708
Faeces soft 40.90 13.87 26 982890 8297 78753175
Hypopnoea 40.84 13.87 8 982908 5321 78756151
Loose body in joint 40.84 13.87 64 982852 1231 78760241
Burn infection 40.68 13.87 17 982899 31 78761441
Inappropriate schedule of product administration 40.66 13.87 2026 980890 131602 78629870
Dermatitis acneiform 40.49 13.87 38 982878 9955 78751517
Hangnail 40.43 13.87 15 982901 16 78761456
Haemolytic uraemic syndrome 40.37 13.87 4 982912 4445 78757027
Diffuse large B-cell lymphoma recurrent 40.31 13.87 3 982913 4204 78757268
Staphylococcal sepsis 40.23 13.87 75 982841 14651 78746821
Culture urine positive 40.21 13.87 4 982912 4431 78757041
Injury 40.18 13.87 692 982224 76804 78684668
Retching 40.17 13.87 98 982818 17369 78744103
Dislocation of vertebra 40.16 13.87 198 982718 7682 78753790
Autonomic nervous system imbalance 39.90 13.87 5 982911 4625 78756847
Small intestinal haemorrhage 39.80 13.87 3 982913 4160 78757312
Injection site anaesthesia 39.79 13.87 16 982900 25 78761447
Sudden cardiac death 39.72 13.87 8 982908 5217 78756255
Lacunar infarction 39.69 13.87 12 982904 5945 78755527
Obstruction 39.67 13.87 5 982911 4605 78756867
Spinal laminectomy 39.63 13.87 44 982872 594 78760878
Blood iron abnormal 39.61 13.87 65 982851 1302 78760170
Tumour haemorrhage 39.58 13.87 3 982913 4141 78757331
Anal fistula 39.53 13.87 18 982898 6926 78754546
Fungaemia 39.46 13.87 5 982911 4586 78756886
Post transplant lymphoproliferative disorder 39.36 13.87 50 982866 11414 78750058
Pathological fracture 39.35 13.87 43 982873 10494 78750978
Exposure to toxic agent 39.30 13.87 33 982883 9125 78752347
Pseudomembranous colitis 39.28 13.87 9 982907 5365 78756107
Infusion site pruritus 39.27 13.87 3 982913 4115 78757357
Mean cell volume increased 39.20 13.87 14 982902 6239 78755233
Refusal of treatment by patient 39.08 13.87 32 982884 8959 78752513
Lipodystrophy acquired 38.95 13.87 4 982912 4321 78757151
Nasal discharge discolouration 38.94 13.87 92 982824 2429 78759043
Phlebitis 38.91 13.87 31 982885 8799 78752673
Throat tightness 38.88 13.87 194 982722 27713 78733759
Ovarian neoplasm 38.87 13.87 43 982873 578 78760894
Aortic stenosis 38.82 13.87 22 982894 7473 78753999
Troponin I increased 38.75 13.87 6 982910 4732 78756740
Sleep disorder 38.60 13.87 1354 981562 84323 78677149
Bacterial test positive 38.39 13.87 22 982894 7427 78754045
Hyperventilation 38.38 13.87 25 982891 7874 78753598
Exposure via skin contact 38.16 13.87 32 982884 297 78761175
Female genital tract fistula 38.10 13.87 13 982903 5962 78755510
Eyelid ptosis 38.10 13.87 48 982868 10996 78750476
Skin reaction 38.09 13.87 333 982583 15735 78745737
Epstein-Barr virus infection 38.00 13.87 75 982841 14341 78747131
Contrast media allergy 37.83 13.87 91 982825 2431 78759041
High density lipoprotein decreased 37.83 13.87 6 982910 4649 78756823
Neoplasm recurrence 37.69 13.87 4 982912 4210 78757262
Gangrene 37.61 13.87 33 982883 8931 78752541
Psychiatric decompensation 37.48 13.87 3 982913 3960 78757512
Craniocerebral injury 37.39 13.87 9 982907 5187 78756285
Seronegative arthritis 37.28 13.87 135 982781 4557 78756915
Areflexia 37.14 13.87 11 982905 5523 78755949
Bacterial sepsis 37.12 13.87 28 982888 8170 78753302
Paralysis 36.99 13.87 66 982850 13111 78748361
Neck mass 36.95 13.87 129 982787 4275 78757197
Nephrolithiasis 36.92 13.87 889 982027 52402 78709070
Bradyarrhythmia 36.91 13.87 4 982912 4142 78757330
Lung transplant 36.80 13.87 6 982910 4555 78756917
Blood glucose decreased 36.76 13.87 182 982734 26052 78735420
Pulmonary arterial pressure increased 36.73 13.87 6 982910 4549 78756923
Portal vein thrombosis 36.60 13.87 13 982903 5814 78755658
Cerebellar syndrome 36.58 13.87 11 982905 5469 78756003
Cyst removal 36.49 13.87 37 982879 447 78761025
Haemarthrosis 36.45 13.87 13 982903 5799 78755673
Cell death 36.13 13.87 7 982909 4692 78756780
Menopause 36.11 13.87 80 982836 2022 78759450
Escherichia sepsis 36.09 13.87 31 982885 8477 78752995
Animal scratch 36.03 13.87 65 982851 1409 78760063
Body temperature abnormal 35.95 13.87 86 982830 2289 78759183
Scar excision 35.92 13.87 18 982898 59 78761413
Generalised oedema 35.86 13.87 160 982756 23549 78737923
Swelling of eyelid 35.72 13.87 3 982913 3808 78757664
Tendonitis 35.71 13.87 450 982466 23380 78738092
Sleep terror 35.66 13.87 6 982910 4452 78757020
Skin hyperpigmentation 35.64 13.87 23 982893 7280 78754192
Hepatorenal syndrome 35.63 13.87 5 982911 4244 78757228
Pharyngeal swelling 35.42 13.87 26 982890 7693 78753779
Prostate infection 35.39 13.87 42 982874 612 78760860
Deafness transitory 35.38 13.87 52 982864 943 78760529
Sputum culture positive 35.38 13.87 3 982913 3778 78757694
Extrasystoles 35.34 13.87 24 982892 7395 78754077
Stenotrophomonas infection 35.28 13.87 3 982913 3770 78757702
Adjustment disorder 35.26 13.87 4 982912 3996 78757476
Thrombophlebitis 35.17 13.87 17 982899 6318 78755154
Dysaesthesia 35.14 13.87 14 982902 5834 78755638
Head discomfort 35.14 13.87 302 982614 14200 78747272
Blood sodium increased 35.14 13.87 8 982908 4790 78756682
Ocular icterus 35.02 13.87 12 982904 5488 78755984
Vaginal haemorrhage 34.98 13.87 144 982772 21673 78739799
Intestinal sepsis 34.93 13.87 49 982867 850 78760622
Neurological symptom 34.88 13.87 34 982882 8749 78752723
Acute graft versus host disease in skin 34.87 13.87 26 982890 7632 78753840
Tonsillectomy 34.83 13.87 41 982875 592 78760880
Injection site hyperaesthesia 34.77 13.87 17 982899 52 78761420
Enterobacter infection 34.65 13.87 7 982909 4555 78756917
Pharyngitis 34.59 13.87 425 982491 21950 78739522
Skin papilloma 34.47 13.87 154 982762 5732 78755740
Microcytic anaemia 34.47 13.87 11 982905 5263 78756209
Pulmonary function test abnormal 34.46 13.87 5 982911 4139 78757333
Rocky mountain spotted fever 34.40 13.87 14 982902 23 78761449
Intervertebral disc space narrowing 34.39 13.87 70 982846 1665 78759807
Insurance issue 34.33 13.87 151 982765 5582 78755890
Hospitalisation 34.32 13.87 891 982025 93345 78668127
Nephrogenic anaemia 34.15 13.87 4 982912 3898 78757574
Hepatosplenomegaly 34.13 13.87 16 982900 6053 78755419
Ligament operation 34.08 13.87 13 982903 16 78761456
Urinary bladder suspension 34.05 13.87 21 982895 113 78761359
Autoimmune hepatitis 34 13.87 58 982858 11725 78749747
Urine analysis abnormal 33.97 13.87 19 982897 6501 78754971
Communication disorder 33.86 13.87 5 982911 4085 78757387
Blood thyroid stimulating hormone decreased 33.83 13.87 14 982902 5702 78755770
Visual field defect 33.68 13.87 37 982879 9008 78752464
Muscle twitching 33.45 13.87 174 982742 24590 78736882
Oesophageal carcinoma 33.44 13.87 53 982863 11031 78750441
Gout 33.37 13.87 174 982742 24575 78736897
Sexual dysfunction 33.28 13.87 28 982888 7735 78753737
Tenoplasty 33.27 13.87 18 982898 72 78761400
Oesophageal varices haemorrhage 33.23 13.87 6 982910 4230 78757242
Anal haemorrhage 33.21 13.87 6 982910 4228 78757244
Device breakage 33.20 13.87 50 982866 10625 78750847
Blindness 33.19 13.87 209 982707 28174 78733298
Spinal compression fracture 33.13 13.87 103 982813 16855 78744617
Meniscus operation 33.12 13.87 23 982893 156 78761316
Pollakiuria 33.07 13.87 297 982619 37020 78724452
Eating disorder 32.94 13.87 137 982779 20560 78740912
Laryngospasm 32.83 13.87 5 982911 3992 78757480
Sunburn 32.79 13.87 113 982803 3720 78757752
Pulmonary sarcoidosis 32.74 13.87 60 982856 1317 78760155
Spinal column injury 32.64 13.87 79 982837 2119 78759353
Restless legs syndrome 32.60 13.87 132 982784 19960 78741512
Hyperaesthesia teeth 32.55 13.87 71 982845 1775 78759697
Lymph node pain 32.48 13.87 64 982852 1486 78759986
Basal cell carcinoma 32.44 13.87 644 982272 36731 78724741
Flank pain 32.43 13.87 130 982786 19714 78741758
Haemoperitoneum 32.29 13.87 7 982909 4336 78757136
Diarrhoea haemorrhagic 32.24 13.87 72 982844 13162 78748310
Dilatation ventricular 32.23 13.87 6 982910 4138 78757334
Pneumonia klebsiella 32.22 13.87 11 982905 5043 78756429
Abnormal dreams 32.18 13.87 57 982859 11355 78750117
Hepatic enzyme abnormal 32.12 13.87 185 982731 7625 78753847
Tendon disorder 32.07 13.87 174 982742 7012 78754460
Limb injury 32.05 13.87 527 982389 29001 78732471
Vitreous haemorrhage 32.02 13.87 4 982912 3709 78757763
Malabsorption 32.00 13.87 11 982905 5021 78756451
Urinary tract infection bacterial 31.96 13.87 20 982896 6436 78755036
Dilatation atrial 31.92 13.87 4 982912 3700 78757772
Anticipatory anxiety 31.89 13.87 55 982861 1149 78760323
Upper limb fracture 31.66 13.87 350 982566 17617 78743855
Peripheral arterial occlusive disease 31.62 13.87 33 982883 8225 78753247
Type IV hypersensitivity reaction 31.55 13.87 6 982910 4075 78757397
Lyme disease 31.53 13.87 102 982814 3248 78758224
Breast cancer stage I 31.48 13.87 22 982894 6678 78754794
Hearing aid user 31.37 13.87 15 982901 43 78761429
Low density lipoprotein increased 31.31 13.87 36 982880 8586 78752886
Red blood cells urine positive 31.30 13.87 11 982905 4952 78756520
Sputum increased 31.27 13.87 9 982907 4604 78756868
Conjunctival hyperaemia 31.06 13.87 8 982908 4405 78757067
Epicondylitis 30.98 13.87 77 982839 2101 78759371
False positive tuberculosis test 30.93 13.87 12 982904 16 78761456
Neurogenic bladder 30.89 13.87 7 982909 4205 78757267
Arthritis infective 30.87 13.87 191 982725 8080 78753392
SARS-CoV-2 test positive 30.84 13.87 61 982855 11655 78749817
Injection site discharge 30.75 13.87 44 982872 778 78760694
Pyelonephritis acute 30.74 13.87 18 982898 6005 78755467
Clostridial infection 30.72 13.87 16 982900 5698 78755774
Paraparesis 30.69 13.87 5 982911 3798 78757674
Product administered to patient of inappropriate age 30.68 13.87 15 982901 5538 78755934
Epidural injection 30.68 13.87 9 982907 0 78761472
Product physical issue 30.60 13.87 7 982909 4178 78757294
Panic attack 30.59 13.87 174 982742 24042 78737430
Rib fracture 30.55 13.87 210 982706 27737 78733735
Acute psychosis 30.55 13.87 7 982909 4173 78757299
Wound dehiscence 30.54 13.87 22 982894 6573 78754899
Artificial crown procedure 30.53 13.87 26 982890 247 78761225
Cast application 30.50 13.87 11 982905 10 78761462
Premature labour 30.50 13.87 35 982881 8355 78753117
Frustration tolerance decreased 30.40 13.87 177 982739 7325 78754147
Mesenteritis 30.29 13.87 29 982887 325 78761147
Injection site infection 30.21 13.87 77 982839 2135 78759337
Myasthenia gravis 30.18 13.87 51 982865 10348 78751124
Product distribution issue 30.16 13.87 58 982858 1322 78760150
Alanine aminotransferase abnormal 30.15 13.87 200 982716 8667 78752805
Extravasation 30.10 13.87 5 982911 3745 78757727
Bicytopenia 30.06 13.87 10 982906 4660 78756812
Mammoplasty 29.92 13.87 27 982889 279 78761193
White blood cells urine positive 29.82 13.87 19 982897 6056 78755416
Skin swelling 29.81 13.87 113 982803 3901 78757571
Social avoidant behaviour 29.80 13.87 11 982905 4803 78756669
Focal dyscognitive seizures 29.76 13.87 4 982912 3508 78757964
Nasal ulcer 29.75 13.87 75 982841 2065 78759407
Electric shock 29.74 13.87 58 982858 1336 78760136
Palmoplantar keratoderma 29.73 13.87 5 982911 3711 78757761
Ingrown hair 29.70 13.87 41 982875 700 78760772
Megacolon 29.57 13.87 4 982912 3491 78757981
Arthroscopic surgery 29.56 13.87 14 982902 39 78761433
Prescription drug used without a prescription 29.54 13.87 7 982909 4078 78757394
Urinary hesitation 29.52 13.87 8 982908 4258 78757214
Trigger finger 29.48 13.87 117 982799 4128 78757344
Diverticulum 29.44 13.87 90 982826 14806 78746666
Anaphylactoid reaction 29.42 13.87 15 982901 5407 78756065
Infected bite 29.34 13.87 70 982846 1860 78759612
Liver transplant 29.31 13.87 9 982907 4414 78757058
Injection site scab 29.27 13.87 29 982887 340 78761132
Disability assessment scale score increased 29.16 13.87 4 982912 3454 78758018
Drug effective for unapproved indication 29.14 13.87 19 982897 5982 78755490
Secondary immunodeficiency 29.10 13.87 3 982913 3231 78758241
Prothrombin time shortened 29.03 13.87 3 982913 3225 78758247
Rhonchi 29.02 13.87 7 982909 4029 78757443
Tonsillar ulcer 29.00 13.87 31 982885 400 78761072
Anger 28.96 13.87 111 982805 17051 78744421
Asthma-chronic obstructive pulmonary disease overlap syndrome 28.95 13.87 3 982913 3218 78758254
Anosmia 28.91 13.87 40 982876 8804 78752668
Body height decreased 28.86 13.87 38 982878 8542 78752930
Dactylitis 28.77 13.87 87 982829 2670 78758802
Venous injury 28.64 13.87 42 982874 760 78760712
Blood immunoglobulin G decreased 28.61 13.87 4 982912 3405 78758067
Diffuse alveolar damage 28.50 13.87 5 982911 3599 78757873
Chronic sinusitis 28.47 13.87 75 982841 12951 78748521
Metastases to meninges 28.47 13.87 5 982911 3596 78757876
Macular oedema 28.45 13.87 16 982900 5458 78756014
Viral infection 28.42 13.87 713 982203 42303 78719169
Muscle swelling 28.39 13.87 43 982873 802 78760670
Impaired quality of life 28.38 13.87 87 982829 14299 78747173
Hepatitis toxic 28.29 13.87 14 982902 5133 78756339
Swollen joint count increased 28.24 13.87 418 982498 22509 78738963
Gastrointestinal sounds abnormal 28.08 13.87 16 982900 5419 78756053
Injection site erosion 28.06 13.87 19 982897 123 78761349
Endocarditis 28.05 13.87 55 982861 10542 78750930
Local reaction 28.04 13.87 36 982880 571 78760901
Cardiac dysfunction 28.04 13.87 8 982908 4116 78757356
Urinary tract infection 27.92 13.87 2959 979957 271553 78489919
Arterial occlusive disease 27.89 13.87 38 982878 8418 78753054
Adenovirus infection 27.82 13.87 38 982878 8409 78753063
Kidney fibrosis 27.75 13.87 5 982911 3530 78757942
Urinary tract obstruction 27.68 13.87 12 982904 4753 78756719
Exposed bone in jaw 27.65 13.87 6 982910 3714 78757758
Lack of injection site rotation 27.61 13.87 34 982882 516 78760956
Herpes simplex 27.54 13.87 69 982847 12118 78749354
Application site pain 27.50 13.87 12 982904 4735 78756737
Meningitis cryptococcal 27.43 13.87 5 982911 3501 78757971
Cardiopulmonary failure 27.39 13.87 26 982890 6775 78754697
JC virus infection 27.38 13.87 7 982909 3874 78757598
Dizziness postural 27.19 13.87 64 982852 11485 78749987
Red blood cell sedimentation rate 27.07 13.87 138 982778 5427 78756045
Ear discomfort 27.05 13.87 190 982726 8393 78753079
Metastases to peritoneum 27.05 13.87 10 982906 4362 78757110
Dissociation 26.97 13.87 8 982908 4013 78757459
Accident 26.96 13.87 194 982722 8637 78752835
Amnesia 26.90 13.87 582 982334 62475 78698997
Reaction to preservatives 26.88 13.87 23 982893 220 78761252
Facial paralysis 26.84 13.87 151 982765 20921 78740551
Miliaria 26.84 13.87 60 982856 1526 78759946
Visual impairment 26.82 13.87 1391 981525 90740 78670732
Thyroid cancer 26.78 13.87 138 982778 5450 78756022
Self-injurious ideation 26.77 13.87 6 982910 3632 78757840
Chronic respiratory failure 26.69 13.87 3 982913 3019 78758453
Lymphadenopathy 26.66 13.87 852 982064 52395 78709077
Prosthesis user 26.47 13.87 15 982901 67 78761405
Thrombocytosis 26.46 13.87 40 982876 8486 78752986
Streptococcal bacteraemia 26.43 13.87 6 982910 3600 78757872
Spondylitis 26.37 13.87 122 982794 4609 78756863
Monocyte count decreased 26.30 13.87 4 982912 3197 78758275
Intracardiac thrombus 26.26 13.87 10 982906 4283 78757189
Calciphylaxis 26.22 13.87 7 982909 3763 78757709
Ankle arthroplasty 26.15 13.87 58 982858 1467 78760005
Drug eruption 26.07 13.87 718 982198 43217 78718255
Malignant pleural effusion 26.06 13.87 5 982911 3375 78758097
Conduction disorder 26.05 13.87 5 982911 3374 78758098
Adrenal insufficiency 26.00 13.87 225 982691 28262 78733210
Non-small cell lung cancer 25.99 13.87 24 982892 6336 78755136
Mouth haemorrhage 25.98 13.87 60 982856 10839 78750633
Middle ear effusion 25.95 13.87 77 982839 2338 78759134
Internal haemorrhage 25.93 13.87 43 982873 8790 78752682
Fixed eruption 25.92 13.87 3 982913 2951 78758521
Peripheral motor neuropathy 25.92 13.87 5 982911 3362 78758110
Ependymoma malignant 25.92 13.87 10 982906 13 78761459
Infusion site bruising 25.90 13.87 3 982913 2949 78758523
Weight bearing difficulty 25.87 13.87 93 982823 3128 78758344
Diabetic nephropathy 25.84 13.87 3 982913 2944 78758528
Injection site plaque 25.82 13.87 18 982898 123 78761349
Myoglobin blood increased 25.75 13.87 4 982912 3147 78758325
Strongyloidiasis 25.71 13.87 8 982908 3890 78757582
Anion gap increased 25.70 13.87 7 982909 3713 78757759
Type I hypersensitivity 25.67 13.87 11 982905 4387 78757085
Injection site cellulitis 25.66 13.87 61 982855 1617 78759855
Amyotrophic lateral sclerosis 25.64 13.87 64 982852 1751 78759721
Pulmonary sepsis 25.61 13.87 7 982909 3705 78757767
Cataract 25.61 13.87 972 981944 61148 78700324
Acute abdomen 25.59 13.87 4 982912 3133 78758339
Lichenoid keratosis 25.57 13.87 9 982907 4048 78757424
Mucous stools 25.54 13.87 16 982900 5146 78756326
Linear IgA disease 25.54 13.87 4 982912 3128 78758344
Hyperthermia malignant 25.50 13.87 3 982913 2914 78758558
Cold sweat 25.48 13.87 131 982785 18568 78742904
Focal segmental glomerulosclerosis 25.42 13.87 5 982911 3316 78758156
Vascular pseudoaneurysm 25.41 13.87 6 982910 3504 78757968
Cytomegalovirus colitis 25.36 13.87 13 982903 4672 78756800
Plantar fasciitis 25.36 13.87 97 982819 3363 78758109
Hepatitis B virus test positive 25.29 13.87 31 982885 468 78761004
Periorbital swelling 25.27 13.87 3 982913 2893 78758579
Multiple injuries 25.25 13.87 6 982910 3489 78757983
Coronary artery occlusion 25.24 13.87 100 982816 15215 78746257
Arthroscopy 25.19 13.87 32 982884 502 78760970
Vascular purpura 25.16 13.87 4 982912 3094 78758378
Pneumomediastinum 25.14 13.87 7 982909 3660 78757812
Episcleritis 25.12 13.87 46 982870 1009 78760463
Haemorrhoidal haemorrhage 25.08 13.87 28 982888 6767 78754705
Periodontitis 25.06 13.87 12 982904 4484 78756988
Tonsillitis 25.03 13.87 155 982761 6559 78754913
Hepatitis B reactivation 25.01 13.87 23 982893 6085 78755387
Staphylococcal infection 24.96 13.87 916 982000 57379 78704093
Pruritus genital 24.96 13.87 12 982904 4474 78756998
Psychiatric symptom 24.87 13.87 30 982886 7005 78754467
Enterococcal bacteraemia 24.83 13.87 4 982912 3064 78758408
Ligament disorder 24.81 13.87 27 982889 356 78761116
Blood parathyroid hormone increased 24.72 13.87 6 982910 3439 78758033
Foetal death 24.71 13.87 38 982878 8006 78753466
Thyroiditis 24.60 13.87 13 982903 4592 78756880
Mean cell haemoglobin increased 24.56 13.87 11 982905 4274 78757198
Stillbirth 24.54 13.87 9 982907 3946 78757526
Ear disorder 24.54 13.87 106 982810 3887 78757585
Pneumonia pseudomonal 24.52 13.87 22 982894 5889 78755583
Polycystic ovaries 24.49 13.87 8 982908 3771 78757701
Injection related reaction 24.45 13.87 45 982871 991 78760481
Hereditary angioedema 24.44 13.87 18 982898 5317 78756155
Tumour marker increased 24.43 13.87 11 982905 4261 78757211
Paresis 24.33 13.87 11 982905 4250 78757222
Syringe issue 24.30 13.87 25 982891 6273 78755199
Precancerous cells present 24.29 13.87 49 982867 1158 78760314
Pneumonia staphylococcal 24.26 13.87 15 982901 4859 78756613
Hepatic lesion 24.26 13.87 30 982886 6929 78754543
Fibrosis 24.21 13.87 18 982898 5291 78756181
Tension headache 24.19 13.87 32 982884 7179 78754293
Procalcitonin increased 24.15 13.87 4 982912 3002 78758470
Procedural haemorrhage 24.11 13.87 14 982902 4692 78756780
Hypercalcaemia 24.06 13.87 331 982585 38099 78723373
Hypokinesia 24.05 13.87 137 982779 18923 78742549
Hypertensive emergency 24.02 13.87 3 982913 2782 78758690
Liver injury 24.01 13.87 523 982393 56091 78705381
Subcutaneous haematoma 23.93 13.87 3 982913 2774 78758698
Mycobacterium tuberculosis complex test 23.86 13.87 7 982909 0 78761472
Escherichia test positive 23.85 13.87 5 982911 3170 78758302
Folate deficiency 23.82 13.87 6 982910 3354 78758118
Device related sepsis 23.82 13.87 25 982891 6215 78755257
Pruritus allergic 23.76 13.87 53 982863 1346 78760126
Gastric perforation 23.71 13.87 10 982906 4027 78757445
Needle issue 23.69 13.87 256 982660 12812 78748660
PO2 decreased 23.68 13.87 4 982912 2959 78758513
Optic ischaemic neuropathy 23.65 13.87 4 982912 2957 78758515
Troponin T increased 23.64 13.87 7 982909 3515 78757957
Enteritis infectious 23.59 13.87 6 982910 3332 78758140
Abdominal abscess 23.53 13.87 32 982884 7095 78754377
Autoimmune haemolytic anaemia 23.50 13.87 42 982874 8338 78753134
Cartilage injury 23.50 13.87 56 982860 1487 78759985
Hypoaesthesia oral 23.42 13.87 92 982824 14032 78747440
Breast cancer metastatic 23.33 13.87 44 982872 8558 78752914
Manufacturing product shipping issue 23.31 13.87 15 982901 88 78761384
Sensory disturbance 23.26 13.87 101 982815 14976 78746496
Venous thrombosis limb 23.20 13.87 13 982903 4444 78757028
Multiple fractures 23.18 13.87 174 982742 7852 78753620
Abdominal tenderness 23.16 13.87 61 982855 10533 78750939
Motor dysfunction 23.15 13.87 98 982818 14635 78746837
Prescribed underdose 23.15 13.87 242 982674 29272 78732200
Diabetic retinopathy 23.11 13.87 5 982911 3101 78758371
Pneumonia influenzal 23.03 13.87 4 982912 2900 78758572
Psychotic symptom 23.03 13.87 3 982913 2694 78758778
Synovial disorder 23.02 13.87 65 982851 1918 78759554
Paradoxical drug reaction 22.99 13.87 33 982883 7152 78754320
Oesophageal pain 22.98 13.87 12 982904 4267 78757205
Biliary colic 22.98 13.87 10 982906 3952 78757520
Thinking abnormal 22.94 13.87 84 982832 13077 78748395
Gastric bypass 22.90 13.87 50 982866 1251 78760221
Hepatocellular carcinoma 22.87 13.87 48 982868 8973 78752499
Livedo reticularis 22.79 13.87 11 982905 4092 78757380
Wisdom teeth removal 22.78 13.87 29 982887 456 78761016
Fracture 22.76 13.87 166 982750 21635 78739837
Enterocolitis infectious 22.65 13.87 4 982912 2865 78758607
Hyperparathyroidism secondary 22.61 13.87 3 982913 2657 78758815
Wrong technique in device usage process 22.55 13.87 104 982812 3924 78757548
Jugular vein thrombosis 22.54 13.87 14 982902 4524 78756948
Large intestinal stenosis 22.50 13.87 4 982912 2852 78758620
Mallory-Weiss syndrome 22.46 13.87 4 982912 2848 78758624
Bronchial wall thickening 22.40 13.87 3 982913 2638 78758834
Abdominal operation 22.40 13.87 32 982884 565 78760907
Idiopathic intracranial hypertension 22.38 13.87 6 982910 3216 78758256
Eyelid exfoliation 22.37 13.87 17 982899 135 78761337
Right ventricular dysfunction 22.33 13.87 3 982913 2632 78758840
Investigation abnormal 22.32 13.87 66 982850 2000 78759472
Hypertensive heart disease 22.28 13.87 12 982904 4194 78757278
Hypoproteinaemia 22.24 13.87 11 982905 4035 78757437
Nail discolouration 22.24 13.87 85 982831 2946 78758526
Alcoholism 22.23 13.87 9 982907 3714 78757758
Large intestinal ulcer 22.21 13.87 16 982900 4781 78756691
Respiratory symptom 22.16 13.87 16 982900 4775 78756697
Secondary adrenocortical insufficiency 22.12 13.87 5 982911 3009 78758463
Abnormal faeces 22.09 13.87 37 982879 7534 78753938
Aphthous ulcer 22.07 13.87 120 982796 16769 78744703
Hyperleukocytosis 22.05 13.87 3 982913 2607 78758865
Blood creatine phosphokinase MB increased 22.01 13.87 4 982912 2807 78758665
Aortic dissection 21.99 13.87 12 982904 4163 78757309
Epstein-Barr virus associated lymphoproliferative disorder 21.98 13.87 8 982908 3524 78757948
Road traffic accident 21.95 13.87 699 982217 42965 78718507
Mucosal disorder 21.94 13.87 8 982908 3520 78757952
Ankle fracture 21.94 13.87 312 982604 16657 78744815
Pulmonary infarction 21.87 13.87 10 982906 3839 78757633
Superinfection 21.86 13.87 17 982899 4885 78756587
Gastric infection 21.83 13.87 98 982818 3655 78757817
Micturition urgency 21.82 13.87 81 982835 12560 78748912
Spinal nerve stimulator implantation 21.77 13.87 14 982902 82 78761390
Oesophageal candidiasis 21.77 13.87 51 982865 9167 78752305
Varices oesophageal 21.77 13.87 25 982891 5966 78755506
Immobile 21.77 13.87 154 982762 6819 78754653
Extremity necrosis 21.74 13.87 6 982910 3155 78758317
Angle closure glaucoma 21.72 13.87 5 982911 2971 78758501
Spinal cord compression 21.70 13.87 28 982888 6349 78755123
Bursa removal 21.68 13.87 9 982907 16 78761456
Quadriparesis 21.67 13.87 8 982908 3493 78757979
Acinetobacter infection 21.64 13.87 4 982912 2773 78758699
Polychondritis 21.63 13.87 31 982885 549 78760923
Breast cancer stage II 21.62 13.87 42 982874 8078 78753394
Ovarian cancer 21.60 13.87 101 982815 3833 78757639
Accident at work 21.57 13.87 45 982871 1090 78760382
Mean cell haemoglobin concentration decreased 21.56 13.87 15 982901 4564 78756908
Coronavirus infection 21.54 13.87 37 982879 7460 78754012
Eyelid oedema 21.53 13.87 91 982825 13596 78747876
Bursa disorder 21.48 13.87 21 982895 242 78761230
Sensitisation 21.47 13.87 7 982909 3304 78758168
Polydipsia 21.46 13.87 30 982886 6575 78754897
Bone deformity 21.39 13.87 24 982892 328 78761144
Biliary dyskinesia 21.33 13.87 3 982913 2542 78758930
Choking 21.25 13.87 77 982839 12024 78749448
Central venous catheterisation 21.25 13.87 7 982909 3282 78758190
Ischaemic cerebral infarction 21.22 13.87 3 982913 2532 78758940
Liver abscess 21.21 13.87 26 982890 6028 78755444
Amenorrhoea 21.17 13.87 39 982877 7653 78753819
Metastases to lymph nodes 21.14 13.87 62 982854 10335 78751137
Ototoxicity 21.09 13.87 7 982909 3267 78758205
Meningitis aseptic 21.02 13.87 33 982883 6895 78754577
Intervertebral disc disorder 20.97 13.87 116 982800 4709 78756763
Infected cyst 20.93 13.87 48 982868 1242 78760230
Pancreatitis necrotising 20.93 13.87 11 982905 3897 78757575
Multiple allergies 20.90 13.87 209 982707 10251 78751221
Klebsiella sepsis 20.87 13.87 7 982909 3245 78758227
Bladder operation 20.85 13.87 39 982877 870 78760602
Oral infection 20.80 13.87 131 982785 5576 78755896
Movement disorder 20.78 13.87 225 982691 27034 78734438
Body tinea 20.77 13.87 60 982856 1794 78759678
Acute graft versus host disease in intestine 20.73 13.87 12 982904 4029 78757443
Hyporeflexia 20.70 13.87 9 982907 3559 78757913
Haematocrit increased 20.67 13.87 12 982904 4022 78757450
Reversible cerebral vasoconstriction syndrome 20.66 13.87 6 982910 3051 78758421
Subacute cutaneous lupus erythematosus 20.63 13.87 9 982907 3552 78757920
Eosinophil count decreased 20.62 13.87 8 982908 3388 78758084
Urine abnormality 20.61 13.87 44 982872 8175 78753297
Metabolic surgery 20.53 13.87 45 982871 1129 78760343
Increased appetite 20.52 13.87 77 982839 11901 78749571
Peptic ulcer 20.49 13.87 28 982888 6195 78755277
Squamous cell carcinoma of skin 20.45 13.87 96 982820 13937 78747535
Anal fissure 20.37 13.87 40 982876 7663 78753809
Infiltration anaesthesia 20.34 13.87 17 982899 157 78761315
Malignant neoplasm of conjunctiva 20.33 13.87 11 982905 44 78761428
Musculoskeletal injury 20.33 13.87 18 982898 181 78761291
Pancreatic carcinoma 20.31 13.87 92 982824 13485 78747987
Joint ankylosis 20.18 13.87 66 982850 2114 78759358
Essential hypertension 20.17 13.87 27 982889 6026 78755446
Initial insomnia 20.16 13.87 34 982882 6904 78754568
Neck deformity 20.15 13.87 59 982857 1778 78759694
Gastrointestinal stoma complication 20.12 13.87 4 982912 2633 78758839
Mole excision 20.10 13.87 16 982900 137 78761335
CD4 lymphocytes decreased 20.09 13.87 4 982912 2630 78758842
Whipple's disease 20.09 13.87 8 982908 12 78761460
Joint injection 20.09 13.87 8 982908 12 78761460
Cytology abnormal 20.02 13.87 23 982893 323 78761149
Oropharyngeal discomfort 20.02 13.87 36 982880 7130 78754342
Alcohol use 20.01 13.87 18 982898 4813 78756659
Pre-eclampsia 20.00 13.87 35 982881 7006 78754466
Carotid artery occlusion 19.97 13.87 40 982876 7607 78753865
Dyschezia 19.94 13.87 6 982910 2982 78758490
Gastric operation 19.94 13.87 21 982895 266 78761206
Tic 19.92 13.87 6 982910 2980 78758492
Gastrointestinal oedema 19.92 13.87 4 982912 2614 78758858
Galactorrhoea 19.91 13.87 10 982906 3636 78757836
Haemoglobin increased 19.78 13.87 28 982888 6104 78755368
Resuscitation 19.76 13.87 3 982913 2401 78759071
Unintended pregnancy 19.72 13.87 12 982904 3921 78757551
Regurgitation 19.72 13.87 5 982911 2782 78758690
Ileal stenosis 19.70 13.87 3 982913 2395 78759077
Trismus 19.66 13.87 23 982893 5444 78756028
Eye inflammation 19.65 13.87 141 982775 6272 78755200
Vasculitis 19.61 13.87 206 982710 24896 78736576
Dysstasia 19.56 13.87 464 982452 27282 78734190
Gingival injury 19.54 13.87 9 982907 23 78761449
Bronchial obstruction 19.52 13.87 5 982911 2763 78758709
Peripheral coldness 19.50 13.87 116 982800 15854 78745618
Limb mass 19.47 13.87 92 982824 3507 78757965
Skin atrophy 19.46 13.87 129 982787 5589 78755883
Bone density abnormal 19.40 13.87 82 982834 2978 78758494
Product prescribing issue 19.38 13.87 13 982903 4032 78757440
Hypochromic anaemia 19.34 13.87 5 982911 2746 78758726
Nail operation 19.32 13.87 32 982884 646 78760826
Upper respiratory tract inflammation 19.29 13.87 13 982903 4022 78757450
Bladder repair 19.27 13.87 11 982905 50 78761422
Oligohydramnios 19.18 13.87 9 982907 3403 78758069
Retinal toxicity 19.15 13.87 49 982867 1362 78760110
Suicidal behaviour 19.14 13.87 8 982908 3239 78758233
Urinary sediment present 19.02 13.87 4 982912 2531 78758941
Terminal state 18.94 13.87 114 982802 4775 78756697
Differentiation syndrome 18.91 13.87 4 982912 2520 78758952
Dermatitis exfoliative generalised 18.81 13.87 38 982878 7203 78754269
Neutrophil count abnormal 18.77 13.87 10 982906 3516 78757956
Hostility 18.72 13.87 3 982913 2307 78759165
Bipolar disorder 18.72 13.87 42 982874 7665 78753807
Red blood cell sedimentation rate decreased 18.71 13.87 20 982896 258 78761214
Tendon sheath incision 18.67 13.87 10 982906 39 78761433
Cholecystectomy 18.62 13.87 188 982728 9244 78752228
Brain abscess 18.59 13.87 20 982896 4916 78756556
Angiopathy 18.53 13.87 37 982879 7045 78754427
Swelling face 18.47 13.87 704 982212 70508 78690964
Peripheral sensorimotor neuropathy 18.43 13.87 7 982909 3003 78758469
Intra-abdominal fluid collection 18.41 13.87 8 982908 3164 78758308
Limb crushing injury 18.39 13.87 19 982897 235 78761237
Defaecation urgency 18.39 13.87 27 982889 5797 78755675
Optic neuropathy 18.37 13.87 10 982906 3474 78757998
Hypercoagulation 18.33 13.87 7 982909 2993 78758479
Myelopathy 18.33 13.87 18 982898 4615 78756857
Bacterial infection 18.32 13.87 273 982643 31007 78730465
Premature baby 18.31 13.87 12 982904 3768 78757704
Blood glucose fluctuation 18.28 13.87 34 982882 6648 78754824
Sensory loss 18.27 13.87 90 982826 12901 78748571
Aphonia 18.23 13.87 201 982715 10111 78751361
Presbyacusis 18.22 13.87 73 982843 2587 78758885
Intervertebral disc compression 18.17 13.87 46 982870 1270 78760202
Bone lesion 18.14 13.87 28 982888 5891 78755581
Injection site streaking 18.12 13.87 10 982906 42 78761430
Affective disorder 18.11 13.87 48 982868 8271 78753201
Rebound psoriasis 18.08 13.87 17 982899 186 78761286
Dysphoria 18.03 13.87 19 982897 4715 78756757
Laryngeal disorder 18.03 13.87 41 982875 1055 78760417
Post procedural haematoma 18.03 13.87 4 982912 2438 78759034
Suspected COVID-19 18.02 13.87 8 982908 3125 78758347
Organ failure 17.97 13.87 14 982902 4019 78757453
Uterine dilation and curettage 17.93 13.87 28 982888 537 78760935
Gastrointestinal motility disorder 17.79 13.87 30 982886 6092 78755380
Pelvic venous thrombosis 17.79 13.87 3 982913 2222 78759250
Acute lymphocytic leukaemia 17.77 13.87 21 982895 4948 78756524
Tonic convulsion 17.73 13.87 3 982913 2217 78759255
Coeliac disease 17.72 13.87 216 982700 11135 78750337
Intervertebral discitis 17.71 13.87 111 982805 4717 78756755
Radiculopathy 17.66 13.87 53 982863 8771 78752701
Drug tolerance 17.65 13.87 174 982742 8501 78752971
Mechanical ventilation 17.65 13.87 6 982910 2758 78758714
Cerebrovascular disorder 17.63 13.87 12 982904 3693 78757779
Bile duct stone 17.56 13.87 26 982890 5563 78755909
Tinea pedis 17.55 13.87 68 982848 2372 78759100
Hepatic cyst 17.54 13.87 30 982886 6059 78755413
Chest X-ray abnormal 17.53 13.87 45 982871 7838 78753634
Polymyalgia rheumatica 17.52 13.87 18 982898 4519 78756953
Haemoglobin abnormal 17.50 13.87 38 982878 7016 78754456
Mononucleosis syndrome 17.48 13.87 14 982902 121 78761351
Generalised anxiety disorder 17.48 13.87 3 982913 2194 78759278
Tendon injury 17.43 13.87 61 982855 2024 78759448
Prostatic operation 17.43 13.87 19 982897 251 78761221
Total lung capacity decreased 17.38 13.87 7 982909 2898 78758574
Glycosuria 17.38 13.87 3 982913 2185 78759287
Hyperparathyroidism 17.37 13.87 9 982907 3215 78758257
Bite 17.32 13.87 27 982889 517 78760955
Serum sickness 17.28 13.87 12 982904 3654 78757818
Laser therapy 17.22 13.87 8 982908 21 78761451
Product availability issue 17.21 13.87 14 982902 3933 78757539
Butterfly rash 17.21 13.87 53 982863 1643 78759829
Product container seal issue 17.21 13.87 12 982904 82 78761390
Precancerous skin lesion 17.18 13.87 46 982870 1315 78760157
Steroid diabetes 17.16 13.87 11 982905 3495 78757977
Adrenocortical insufficiency acute 17.15 13.87 8 982908 3035 78758437
Guillain-Barre syndrome 17.13 13.87 55 982861 8910 78752562
Urinary bladder haemorrhage 17.09 13.87 5 982911 2531 78758941
Neurectomy 17.04 13.87 5 982911 0 78761472
Normocytic anaemia 17.04 13.87 16 982900 4191 78757281
Rheumatoid nodule removal 17.04 13.87 5 982911 0 78761472
Apraxia 17.01 13.87 7 982909 2860 78758612
Hypertonic bladder 16.99 13.87 16 982900 4185 78757287
Allergic oedema 16.99 13.87 33 982883 758 78760714
Peripheral vascular disorder 16.98 13.87 47 982869 7983 78753489
Toxoplasmosis 16.97 13.87 6 982910 2691 78758781
Limb reconstructive surgery 16.94 13.87 10 982906 49 78761423
Enuresis 16.92 13.87 9 982907 3167 78758305
Loss of libido 16.85 13.87 6 982910 2679 78758793
Dental caries 16.78 13.87 221 982695 11599 78749873
Application site rash 16.77 13.87 3 982913 2129 78759343
Varicella zoster virus infection 16.72 13.87 18 982898 4423 78757049
Scarlet fever 16.69 13.87 14 982902 130 78761342
Bruxism 16.68 13.87 15 982901 4011 78757461
Coagulation time prolonged 16.67 13.87 5 982911 2490 78758982
Hot flush 16.66 13.87 532 982384 54345 78707127
In vitro fertilisation 16.64 13.87 11 982905 68 78761404
Hypersensitivity pneumonitis 16.63 13.87 13 982903 3726 78757746
Inflammatory marker increased 16.60 13.87 204 982712 10536 78750936
Cardiovascular insufficiency 16.55 13.87 8 982908 2973 78758499
Product use complaint 16.55 13.87 5 982911 2478 78758994
Laboratory test abnormal 16.54 13.87 458 982458 27590 78733882
Neuroma 16.53 13.87 19 982897 267 78761205
Tumour pain 16.51 13.87 4 982912 2295 78759177
Overwork 16.48 13.87 10 982906 52 78761420
Nail psoriasis 16.48 13.87 29 982887 616 78760856
Illness 16.46 13.87 716 982200 45795 78715677
Large intestinal haemorrhage 16.39 13.87 7 982909 2798 78758674
Paraplegia 16.37 13.87 23 982893 5030 78756442
Pharyngeal operation 16.37 13.87 6 982910 6 78761466
Melkersson-Rosenthal syndrome 16.34 13.87 7 982909 14 78761458
Osteoporosis postmenopausal 16.34 13.87 7 982909 14 78761458
Device alarm issue 16.30 13.87 3 982913 2086 78759386
Hyperaemia 16.29 13.87 9 982907 3101 78758371
Vaginal discharge 16.29 13.87 43 982873 7420 78754052
Skin candida 16.28 13.87 3 982913 2084 78759388
Pneumoperitoneum 16.27 13.87 9 982907 3099 78758373
Disease susceptibility 16.26 13.87 20 982896 303 78761169
Coronary artery thrombosis 16.25 13.87 9 982907 3097 78758375
Lupus vasculitis 16.24 13.87 27 982889 547 78760925
Transaminases abnormal 16.17 13.87 34 982882 828 78760644
Loss of employment 16.15 13.87 69 982847 2518 78758954
Facial paresis 16.13 13.87 27 982889 5499 78755973
Skin sensitisation 16.12 13.87 37 982879 958 78760514
Contrast media reaction 16.09 13.87 3 982913 2067 78759405
Invasive breast carcinoma 16.08 13.87 26 982890 514 78760958
Idiopathic pulmonary fibrosis 16.07 13.87 17 982899 4211 78757261
Pulse abnormal 16.05 13.87 11 982905 3373 78758099
Prolonged labour 15.98 13.87 24 982892 444 78761028
Hepatic cancer 15.96 13.87 71 982845 10458 78751014
Unmasking of previously unidentified disease 15.95 13.87 3 982913 2054 78759418
Migraine 15.95 13.87 1269 981647 86224 78675248
Procedural complication 15.94 13.87 48 982868 7935 78753537
Metastatic bronchial carcinoma 15.93 13.87 18 982898 248 78761224
Spinal meningioma benign 15.92 13.87 12 982904 94 78761378
Body temperature increased 15.90 13.87 421 982495 43999 78717473
Vaginal operation 15.90 13.87 6 982910 7 78761465
Septic embolus 15.89 13.87 3 982913 2048 78759424
Monoparesis 15.88 13.87 12 982904 3499 78757973
Chorea 15.87 13.87 5 982911 2412 78759060
Diabetic neuropathy 15.82 13.87 33 982883 6183 78755289
Flat affect 15.78 13.87 3 982913 2038 78759434
Carotid artery thrombosis 15.76 13.87 9 982907 3044 78758428
Thyroid operation 15.75 13.87 15 982901 167 78761305
Bronchial hyperreactivity 15.63 13.87 9 982907 3031 78758441
Nail bed disorder 15.60 13.87 18 982898 254 78761218
Erosive oesophagitis 15.60 13.87 8 982908 2874 78758598
Antibody test positive 15.57 13.87 72 982844 2720 78758752
Concomitant disease progression 15.55 13.87 12 982904 3461 78758011
Blood creatinine abnormal 15.53 13.87 22 982894 4795 78756677
Ureteric obstruction 15.52 13.87 7 982909 2709 78758763
Continuous haemodiafiltration 15.51 13.87 3 982913 2013 78759459
Synovial rupture 15.50 13.87 21 982895 352 78761120
Procedural pain 15.48 13.87 196 982720 22888 78738584
Retinal detachment 15.48 13.87 60 982856 9187 78752285
Skin irritation 15.48 13.87 209 982707 11031 78750441
Disease complication 15.48 13.87 23 982893 4914 78756558
Biliary obstruction 15.42 13.87 21 982895 4653 78756819
Pelvic pain 15.40 13.87 99 982817 13282 78748190
Intervertebral disc injury 15.40 13.87 15 982901 172 78761300
Anaesthetic complication 15.38 13.87 8 982908 2851 78758621
Fallopian tube cancer 15.37 13.87 8 982908 29 78761443
Chronic disease 15.34 13.87 14 982902 147 78761325
Large intestinal obstruction 15.28 13.87 11 982905 3288 78758184
Small intestinal perforation 15.26 13.87 11 982905 3286 78758186
Catarrh 15.23 13.87 4 982912 2174 78759298
Intentional underdose 15.22 13.87 5 982911 2349 78759123
Peritoneal dialysis complication 15.22 13.87 5 982911 2349 78759123
HLA marker study positive 15.22 13.87 13 982903 124 78761348
Synovectomy 15.17 13.87 17 982899 232 78761240
Large intestine polyp 15.16 13.87 93 982823 12615 78748857
Cystoid macular oedema 15.12 13.87 3 982913 1977 78759495
Eructation 15.10 13.87 76 982840 10833 78750639
Hodgkin's disease 15.08 13.87 33 982883 827 78760645
Lacrimation increased 14.98 13.87 373 982543 22104 78739368
Antinuclear antibody positive 14.97 13.87 156 982760 7734 78753738
Oesophageal stenosis 14.94 13.87 19 982897 4335 78757137
Mucosal erosion 14.86 13.87 5 982911 2313 78759159
Nervous system disorder 14.84 13.87 237 982679 26619 78734853
Discontinued product administered 14.81 13.87 11 982905 84 78761388
Substance-induced psychotic disorder 14.81 13.87 12 982904 3377 78758095
Anti-cyclic citrullinated peptide antibody 14.78 13.87 123 982793 5729 78755743
Splenic infarction 14.77 13.87 14 982902 3650 78757822
Metastasis 14.75 13.87 40 982876 6840 78754632
Papilloma excision 14.73 13.87 5 982911 3 78761469
Thrombocytopenic purpura 14.69 13.87 6 982910 2463 78759009
Prescribed overdose 14.65 13.87 355 982561 37528 78723944
Pulmonary mass 14.65 13.87 465 982451 28569 78732903
Cerebellar infarction 14.62 13.87 14 982902 3633 78757839
Dermatitis allergic 14.61 13.87 309 982607 17821 78743651
Acute sinusitis 14.61 13.87 21 982895 4549 78756923
Labelled drug-disease interaction medication error 14.58 13.87 19 982897 306 78761166
X-ray abnormal 14.58 13.87 122 982794 5691 78755781
Accidental exposure to product by child 14.57 13.87 9 982907 2917 78758555
Muscle atrophy 14.57 13.87 80 982836 11152 78750320
Cutaneous T-cell lymphoma 14.55 13.87 69 982847 2634 78758838
Needle track marks 14.50 13.87 10 982906 67 78761405
Immunosuppression 14.45 13.87 230 982686 12573 78748899
Haemophilus infection 14.43 13.87 5 982911 2271 78759201
Retinopathy 14.40 13.87 16 982900 3875 78757597
Product taste abnormal 14.38 13.87 5 982911 2266 78759206
Oral pain 14.29 13.87 291 982625 31507 78729965
Vocal cord paralysis 14.27 13.87 7 982909 2580 78758892
Vitreous detachment 14.26 13.87 5 982911 2254 78759218
Foaming at mouth 14.22 13.87 3 982913 1894 78759578
Streptococcal infection 14.21 13.87 169 982747 8661 78752811
Lymphoedema 14.21 13.87 92 982824 12321 78749151
Labile blood pressure 14.20 13.87 5 982911 2248 78759224
Computerised tomogram thorax abnormal 14.20 13.87 6 982910 2413 78759059
General physical condition abnormal 14.18 13.87 38 982878 6525 78754947
Oral mucosal roughening 14.18 13.87 7 982909 22 78761450
Traumatic haematoma 14.17 13.87 4 982912 2072 78759400
Cardiac granuloma 14.15 13.87 5 982911 4 78761468
Organising pneumonia 14.14 13.87 78 982838 10861 78750611
Thyroidectomy 14.14 13.87 34 982882 908 78760564
Septic arthritis staphylococcal 14.08 13.87 31 982885 780 78760692
Eastern Cooperative Oncology Group performance status worsened 14.05 13.87 4 982912 2061 78759411
Hair disorder 14.03 13.87 38 982878 1094 78760378
Abdominal adhesions 14.00 13.87 14 982902 3559 78757913
Humerus fracture 13.99 13.87 63 982853 9250 78752222
Hepatitis B 13.99 13.87 54 982862 8278 78753194
Lower respiratory tract inflammation 13.98 13.87 13 982903 140 78761332
Hair colour changes 13.98 13.87 19 982897 4213 78757259
Stem cell transplant 13.96 13.87 15 982901 3689 78757783
Spinal fusion acquired 13.93 13.87 11 982905 93 78761379
Gastrointestinal inflammation 13.92 13.87 47 982869 7497 78753975
Urine leukocyte esterase positive 13.88 13.87 18 982898 4073 78757399

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Tumor necrosis factor alpha (TNF-alpha) inhibitors
FDA MoA N0000175451 Tumor Necrosis Factor Receptor Blocking Activity
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA EPC N0000175610 Tumor Necrosis Factor Blocker

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriasis with arthropathy indication 33339001
Rheumatoid arthritis indication 69896004 DOID:7148
Plaque psoriasis indication 200965009
Juvenile idiopathic arthritis indication 410502007
Nonradiographic axial spondyloarthritis indication 713777005
Sepsis contraindication 91302008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tumor necrosis factor Cytokine INHIBITOR DRUG LABEL DRUG LABEL

External reference:

IDSource
OP401G7OJC UNII
D00742 KEGG_DRUG
4021136 VUID
N0000148590 NUI
4021136 VANDF
C0717758 UMLSCUI
CHEBI:4875 CHEBI
CHEMBL1201572 ChEMBL_ID
DB00005 DRUGBANK_ID
D000068800 MESH_DESCRIPTOR_UI
7783 INN_ID
6789 IUPHAR_LIGAND_ID
2103480 RXNORM
13915 MMSL
33391 MMSL
7788 MMSL
d04365 MMSL
007673 NDDF
016975 NDDF
118259007 SNOMEDCT_US
387045004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-3531 SOLUTION 50 mg SUBCUTANEOUS BLA 32 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-4490 SOLUTION 50 mg SUBCUTANEOUS BLA 29 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 50090-4590 SOLUTION 50 mg SUBCUTANEOUS BLA 32 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-010 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-021 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-032 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-044 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-055 SOLUTION 25 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-435 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-435 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-435 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-435 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-445 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-445 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections
ENBREL HUMAN PRESCRIPTION DRUG LABEL 1 58406-445 SOLUTION 50 mg SUBCUTANEOUS BLA 34 sections