triamcinolone hexacetonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 4976 5611-51-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triamcinolone hexacetonide
  • aristospan
  • hexatrione
  • CL 34433
  • CL-34433
synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems
  • Molecular weight: 532.65
  • Formula: C30H41FO7
  • CLOGP: 4.60
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 99.13
  • ALOGS: -5.23
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 29, 1969 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human antichimeric antibody positive 285.60 171.24 49 1780 1440 50601855
Body height below normal 279.01 171.24 50 1779 1899 50601396
Drug specific antibody 216.81 171.24 40 1789 1785 50601510
Polyarthritis 203.89 171.24 49 1780 7878 50595417
Adrenal insufficiency 198.57 171.24 54 1775 14189 50589106
Bone density decreased 192.46 171.24 50 1779 11025 50592270
Obesity 171.90 171.24 50 1779 16725 50586570

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human antichimeric antibody positive 298.97 154.73 49 1816 1367 64495500
Body height below normal 293.61 154.73 50 1815 1768 64495099
Drug specific antibody 220.20 154.73 40 1825 2055 64494812
Polyarthritis 210.04 154.73 50 1815 9665 64487202
Bone density decreased 208.84 154.73 50 1815 9902 64486965
Adrenal insufficiency 181.63 154.73 53 1812 22434 64474433
Obesity 172.85 154.73 50 1815 20512 64476355

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Lichen planus indication 4776004 DOID:9201
Keloid scar indication 33659008
Lichen simplex chronicus indication 53891004
Necrobiosis lipoidica diabeticorum indication 56391002
Alopecia areata indication 68225006 DOID:986
Discoid lupus erythematosus indication 200938002
Idiopathic thrombocytopenic purpura contraindication 32273002 DOID:8924




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.08 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
I7GT1U99Y9 UNII
D00985 KEGG_DRUG
4017601 VUID
N0000179269 NUI
4017599 VANDF
4017601 VANDF
C0077004 UMLSCUI
CHEBI:9670 CHEBI
CHEBI:9667 CHEBI
CHEMBL1200878 ChEMBL_ID
21826 PUBCHEM_CID
1907 INN_ID
C005900 MESH_SUPPLEMENTAL_RECORD_UI
31307 PUBCHEM_CID
DB00620 DRUGBANK_ID
10759 RXNORM
354456 MMSL
4582 MMSL
5613 MMSL
5616 MMSL
d00620 MMSL
116594009 SNOMEDCT_US
412524002 SNOMEDCT_US
6028009 SNOMEDCT_US
C0040864 UMLSCUI
002188 NDDF
002191 NDDF
D014221 MESH_DESCRIPTOR_UI
755 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hexatrione2% HUMAN PRESCRIPTION DRUG LABEL 1 59137-570 INJECTION, SUSPENSION 40 mg INTRA-ARTICULAR Unapproved drug for use in drug shortage 3 sections