triamcinolone hexacetonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids not used as glucocorticosteroids	4976	5611-51-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

triamcinolone hexacetonide
aristospan
hexatrione
CL 34433
CL-34433

synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems

Molecular weight: 532.65
Formula: C30H41FO7
CLOGP: 4.60
LIPINSKI: 1
HAC: 7
HDO: 1
TPSA: 99.13
ALOGS: -5.23
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 29, 1969	FDA	SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Human antichimeric antibody positive	285.60	171.24	49	1780	1440	50601855
Body height below normal	279.01	171.24	50	1779	1899	50601396
Drug specific antibody	216.81	171.24	40	1789	1785	50601510
Polyarthritis	203.89	171.24	49	1780	7878	50595417
Adrenal insufficiency	198.57	171.24	54	1775	14189	50589106
Bone density decreased	192.46	171.24	50	1779	11025	50592270
Obesity	171.90	171.24	50	1779	16725	50586570

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Human antichimeric antibody positive	298.97	154.73	49	1816	1367	64495500
Body height below normal	293.61	154.73	50	1815	1768	64495099
Drug specific antibody	220.20	154.73	40	1825	2055	64494812
Polyarthritis	210.04	154.73	50	1815	9665	64487202
Bone density decreased	208.84	154.73	50	1815	9902	64486965
Adrenal insufficiency	181.63	154.73	53	1812	22434	64474433
Obesity	172.85	154.73	50	1815	20512	64476355

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:50857	anti-allergic drugs
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Lichen planus	indication	4776004	DOID:9201
Keloid scar	indication	33659008
Lichen simplex chronicus	indication	53891004
Necrobiosis lipoidica diabeticorum	indication	56391002
Alopecia areata	indication	68225006	DOID:986
Discoid lupus erythematosus	indication	200938002
Idiopathic thrombocytopenic purpura	contraindication	32273002	DOID:8924

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.08	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
I7GT1U99Y9	UNII
D00985	KEGG_DRUG
4017601	VUID
N0000179269	NUI
4017599	VANDF
4017601	VANDF
C0077004	UMLSCUI
CHEBI:9670	CHEBI
CHEBI:9667	CHEBI
CHEMBL1200878	ChEMBL_ID
21826	PUBCHEM_CID
1907	INN_ID
C005900	MESH_SUPPLEMENTAL_RECORD_UI
31307	PUBCHEM_CID
DB00620	DRUGBANK_ID
10759	RXNORM
354456	MMSL
4582	MMSL
5613	MMSL
5616	MMSL
d00620	MMSL
116594009	SNOMEDCT_US
412524002	SNOMEDCT_US
6028009	SNOMEDCT_US
C0040864	UMLSCUI
002188	NDDF
002191	NDDF
D014221	MESH_DESCRIPTOR_UI
755	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Hexatrione2%	HUMAN PRESCRIPTION DRUG LABEL	1	59137-570	INJECTION, SUSPENSION	40 mg	INTRA-ARTICULAR	Unapproved drug for use in drug shortage	3 sections