triamcinolone hexacetonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 4976 | 5611-51-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 29, 1969 | FDA | SANDOZ |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Human antichimeric antibody positive | 331.08 | 173.30 | 57 | 2306 | 1657 | 63485002 |
| Body height below normal | 323.90 | 173.30 | 58 | 2305 | 2125 | 63484534 |
| Polyarthritis | 260.59 | 173.30 | 63 | 2300 | 10083 | 63476576 |
| Drug specific antibody | 255.25 | 173.30 | 48 | 2315 | 2307 | 63484352 |
| Adrenal insufficiency | 220.48 | 173.30 | 62 | 2301 | 17853 | 63468806 |
| Bone density decreased | 214.08 | 173.30 | 58 | 2305 | 14554 | 63472105 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Human antichimeric antibody positive | 345.86 | 165.36 | 57 | 2334 | 1584 | 79740413 |
| Body height below normal | 339.97 | 165.36 | 58 | 2333 | 1995 | 79740002 |
| Polyarthritis | 267.74 | 165.36 | 64 | 2327 | 12138 | 79729859 |
| Drug specific antibody | 260.34 | 165.36 | 48 | 2343 | 2580 | 79739417 |
| Bone density decreased | 231.72 | 165.36 | 58 | 2333 | 13289 | 79728708 |
| Adrenal insufficiency | 201.00 | 165.36 | 61 | 2330 | 28426 | 79713571 |
| Obesity | 176.24 | 165.36 | 58 | 2333 | 35067 | 79706930 |
| Antibody test positive | 170.55 | 165.36 | 34 | 2357 | 2758 | 79739239 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Lichen planus | indication | 4776004 | DOID:9201 |
| Keloid scar | indication | 33659008 | |
| Lichen simplex chronicus | indication | 53891004 | |
| Necrobiosis lipoidica diabeticorum | indication | 56391002 | |
| Alopecia areata | indication | 68225006 | DOID:986 |
| Discoid lupus erythematosus | indication | 200938002 | |
| Idiopathic thrombocytopenic purpura | contraindication | 32273002 | DOID:8924 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.08 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | DRUG LABEL | DRUG LABEL |
External reference:
| ID | Source |
|---|---|
| I7GT1U99Y9 | UNII |
| D00985 | KEGG_DRUG |
| 4017601 | VUID |
| N0000179269 | NUI |
| 4017599 | VANDF |
| 4017601 | VANDF |
| C0077004 | UMLSCUI |
| CHEBI:9670 | CHEBI |
| CHEBI:9667 | CHEBI |
| CHEMBL1200878 | ChEMBL_ID |
| 21826 | PUBCHEM_CID |
| 1907 | INN_ID |
| C005900 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB00620 | DRUGBANK_ID |
| 10759 | RXNORM |
| 354456 | MMSL |
| 4582 | MMSL |
| 5613 | MMSL |
| 5616 | MMSL |
| d00620 | MMSL |
| 002188 | NDDF |
| 002191 | NDDF |
| 116594009 | SNOMEDCT_US |
| 412524002 | SNOMEDCT_US |
| 6028009 | SNOMEDCT_US |
| C0040864 | UMLSCUI |
| 755 | INN_ID |
| 31307 | PUBCHEM_CID |
| D014221 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Hexatrione2% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59137-570 | INJECTION, SUSPENSION | 40 mg | INTRA-ARTICULAR | Unapproved drug for use in drug shortage | 3 sections |
| Hexatrione2% | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59137-570 | INJECTION, SUSPENSION | 40 mg | INTRA-ARTICULAR | Unapproved drug for use in drug shortage | 3 sections |