triamcinolone hexacetonide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 4976 5611-51-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triamcinolone hexacetonide
  • aristospan
  • hexatrione
  • CL 34433
  • CL-34433
synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems
  • Molecular weight: 532.65
  • Formula: C30H41FO7
  • CLOGP: 4.60
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 99.13
  • ALOGS: -5.23
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 29, 1969 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human antichimeric antibody positive 261.66 172.55 45 1631 1351 46683035
Body height below normal 255.84 172.55 46 1630 1793 46682593
Juvenile idiopathic arthritis 218.68 172.55 46 1630 4086 46680300
Drug specific antibody 204.89 172.55 36 1640 1224 46683162
Polyarthritis 192.33 172.55 45 1631 6497 46677889
Bone density decreased 179.38 172.55 46 1630 9706 46674680
Adrenal insufficiency 175.09 172.55 48 1628 13076 46671310

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000893 Anti-Inflammatory Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Lichen planus indication 4776004 DOID:9201
Keloid scar indication 33659008
Lichen simplex chronicus indication 53891004
Necrobiosis lipoidica diabeticorum indication 56391002
Alopecia areata indication 68225006 DOID:986
Discoid lupus erythematosus indication 200938002
Idiopathic thrombocytopenic purpura contraindication 32273002 DOID:8924

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.08 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D00985 KEGG_DRUG
4017601 VUID
N0000179269 NUI
4017601 VANDF
C0701378 UMLSCUI
CHEBI:9670 CHEBI
CHEMBL1200878 ChEMBL_ID
21826 PUBCHEM_CID
C005900 MESH_SUPPLEMENTAL_RECORD_UI
1907 INN_ID
I7GT1U99Y9 UNII
DB00620 DRUGBANK_ID
203789 RXNORM
5616 MMSL
002191 NDDF
412524002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hexatrione2% HUMAN PRESCRIPTION DRUG LABEL 1 59137-570 INJECTION, SUSPENSION 40 mg INTRA-ARTICULAR Unapproved drug for use in drug shortage 3 sections