triamcinolone hexacetonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 4976 5611-51-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triamcinolone hexacetonide
  • aristospan
  • hexatrione
  • CL 34433
  • CL-34433
synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems
  • Molecular weight: 532.65
  • Formula: C30H41FO7
  • CLOGP: 4.60
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 99.13
  • ALOGS: -5.23
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 29, 1969 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human antichimeric antibody positive 331.08 173.30 57 2306 1657 63485002
Body height below normal 323.90 173.30 58 2305 2125 63484534
Polyarthritis 260.59 173.30 63 2300 10083 63476576
Drug specific antibody 255.25 173.30 48 2315 2307 63484352
Adrenal insufficiency 220.48 173.30 62 2301 17853 63468806
Bone density decreased 214.08 173.30 58 2305 14554 63472105

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human antichimeric antibody positive 345.86 165.36 57 2334 1584 79740413
Body height below normal 339.97 165.36 58 2333 1995 79740002
Polyarthritis 267.74 165.36 64 2327 12138 79729859
Drug specific antibody 260.34 165.36 48 2343 2580 79739417
Bone density decreased 231.72 165.36 58 2333 13289 79728708
Adrenal insufficiency 201.00 165.36 61 2330 28426 79713571
Obesity 176.24 165.36 58 2333 35067 79706930
Antibody test positive 170.55 165.36 34 2357 2758 79739239

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Lichen planus indication 4776004 DOID:9201
Keloid scar indication 33659008
Lichen simplex chronicus indication 53891004
Necrobiosis lipoidica diabeticorum indication 56391002
Alopecia areata indication 68225006 DOID:986
Discoid lupus erythematosus indication 200938002
Idiopathic thrombocytopenic purpura contraindication 32273002 DOID:8924




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.08 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
I7GT1U99Y9 UNII
D00985 KEGG_DRUG
4017601 VUID
N0000179269 NUI
4017599 VANDF
4017601 VANDF
C0077004 UMLSCUI
CHEBI:9670 CHEBI
CHEBI:9667 CHEBI
CHEMBL1200878 ChEMBL_ID
21826 PUBCHEM_CID
1907 INN_ID
C005900 MESH_SUPPLEMENTAL_RECORD_UI
DB00620 DRUGBANK_ID
10759 RXNORM
354456 MMSL
4582 MMSL
5613 MMSL
5616 MMSL
d00620 MMSL
002188 NDDF
002191 NDDF
116594009 SNOMEDCT_US
412524002 SNOMEDCT_US
6028009 SNOMEDCT_US
C0040864 UMLSCUI
755 INN_ID
31307 PUBCHEM_CID
D014221 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hexatrione2% HUMAN PRESCRIPTION DRUG LABEL 1 59137-570 INJECTION, SUSPENSION 40 mg INTRA-ARTICULAR Unapproved drug for use in drug shortage 3 sections
Hexatrione2% HUMAN PRESCRIPTION DRUG LABEL 1 59137-570 INJECTION, SUSPENSION 40 mg INTRA-ARTICULAR Unapproved drug for use in drug shortage 3 sections