rituximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4975 174722-31-7

Description:

MoleculeDescription

Synonyms:

  • rituximab
  • rituxan
  • MabThera
  • rituximab (genetical recombination)
A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 2, 1998 EMA Roche Registration GmbH
Nov. 26, 1997 FDA GENENTECH
Jan. 25, 2008 PMDA Bayer Yakuhin, Nihon Schering, Zenyaku Kogyo

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 2963.06 11.89 15033 441958 1029732 62002299
Contraindicated product administered 2927.71 11.89 5450 451541 212198 62819833
Drug intolerance 2402.02 11.89 6200 450791 302461 62729570
Treatment failure 2194.37 11.89 4587 452404 194456 62837575
Pemphigus 2136.94 11.89 4329 452662 179397 62852634
Infusion related reaction 2014.54 11.89 5034 451957 240487 62791544
Off label use 2007.93 11.89 9859 447132 664603 62367428
Systemic lupus erythematosus 1995.93 11.89 4545 452446 204373 62827658
Glossodynia 1723.88 11.89 3906 453085 174970 62857061
Synovitis 1602.17 11.89 3899 453092 183019 62849012
Hand deformity 1588.76 11.89 3529 453462 155928 62876103
Arthropathy 1587.04 11.89 4481 452510 230311 62801720
Joint swelling 1432.71 11.89 5389 451602 322277 62709754
Alopecia 1312.97 11.89 5351 451640 332185 62699846
Abdominal discomfort 1266.08 11.89 5110 451881 315775 62716256
Therapeutic product effect decreased 1165.38 11.89 3542 453449 189645 62842386
Wound 1112.65 11.89 3127 453864 160136 62871895
Swelling 1077.24 11.89 4375 452616 271003 62761028
Intentional product use issue 1073.65 11.89 2648 454343 125244 62906787
Product dose omission issue 1045.65 11.89 208 456783 234105 62797926
Anti-cyclic citrullinated peptide antibody positive 1025.43 11.89 2453 454538 113759 62918272
Completed suicide 1007.67 11.89 7 456984 145666 62886365
Hepatic enzyme increased 911.00 11.89 3362 453629 198966 62833065
Pericarditis 875.38 11.89 2499 454492 129080 62902951
Drug interaction 846.84 11.89 296 456695 228835 62803196
Rheumatoid factor positive 824.82 11.89 1855 455136 82551 62949480
Progressive multifocal leukoencephalopathy 820.14 11.89 708 456283 12263 63019768
Product use issue 740.68 11.89 3347 453644 217173 62814858
Discomfort 727.86 11.89 2751 454240 164623 62867408
Toxicity to various agents 718.44 11.89 446 456545 246804 62785227
Hypersensitivity 646.52 11.89 3955 453036 288730 62743301
Fall 632.28 11.89 1163 455828 391171 62640860
Rheumatoid arthritis 628.46 11.89 3535 453456 250284 62781747
Hypogammaglobulinaemia 616.50 11.89 468 456523 6687 63025344
Injection site pain 607.14 11.89 102 456889 129698 62902333
Helicobacter infection 589.53 11.89 1734 455257 91051 62940980
Infection 576.64 11.89 3206 453785 225967 62806064
Duodenal ulcer perforation 559.97 11.89 1636 455355 85573 62946458
Maternal exposure during pregnancy 548.59 11.89 3071 453920 216991 62815040
Musculoskeletal stiffness 542.18 11.89 2696 454295 181922 62850109
Pain 541.20 11.89 7889 449102 732739 62299292
Drug abuse 503.80 11.89 3 456988 72515 62959516
Diffuse large B-cell lymphoma recurrent 498.20 11.89 270 456721 2050 63029981
Dizziness 490.98 11.89 1528 455463 428397 62603634
Diarrhoea 489.00 11.89 3084 453907 712282 62319749
Acute kidney injury 477.50 11.89 723 456268 262692 62769339
Red blood cell sedimentation rate increased 460.38 11.89 994 455997 42988 62989043
Constipation 457.35 11.89 568 456423 224375 62807656
Vomiting 427.43 11.89 2327 454664 557290 62474741
Dehydration 401.55 11.89 393 456598 172961 62859070
Feeling abnormal 370.32 11.89 314 456677 148078 62883953
Overdose 360.50 11.89 189 456802 114889 62917142
Anxiety 354.17 11.89 640 456351 216901 62815130
Ill-defined disorder 346.02 11.89 1333 455658 80422 62951609
Hyponatraemia 338.55 11.89 192 456799 111708 62920323
Suicide attempt 336.41 11.89 27 456964 60891 62971140
Arthralgia 331.76 11.89 5848 451143 563862 62468169
Febrile neutropenia 323.10 11.89 1695 455296 116754 62915277
Drug hypersensitivity 320.87 11.89 3533 453458 307154 62724877
Injection site erythema 318.21 11.89 101 456890 83073 62948958
Nausea 317.40 11.89 4294 452697 850177 62181854
Rash 315.43 11.89 5726 451265 555145 62476886
C-reactive protein increased 312.46 11.89 1431 455560 93276 62938755
Somnolence 307.86 11.89 507 456484 178178 62853853
Cardiac failure congestive 304.32 11.89 142 456849 92291 62939740
Loss of personal independence in daily activities 294.67 11.89 1434 455557 95856 62936175
Drug effective for unapproved indication 294.15 11.89 222 456769 3142 63028889
Dyspnoea 293.62 11.89 3196 453795 658117 62373914
Seizure 293.09 11.89 313 456678 132321 62899710
Tremor 292.29 11.89 312 456679 131927 62900104
C-reactive protein abnormal 290.22 11.89 859 456132 45237 62986794
Depressed level of consciousness 287.50 11.89 50 456941 62028 62970003
Oedema peripheral 285.33 11.89 584 456407 188927 62843104
Hip arthroplasty 285.01 11.89 872 456119 46774 62985257
Rheumatoid nodule 283.18 11.89 471 456520 16684 63015347
Blood pressure fluctuation 282.98 11.89 854 456137 45463 62986568
Suicidal ideation 272.73 11.89 58 456933 62363 62969668
Wrong technique in product usage process 270.18 11.89 59 456932 62281 62969750
Myalgia 269.30 11.89 398 456593 146131 62885900
Blood pressure diastolic abnormal 266.95 11.89 419 456572 14123 63017908
Hepatitis B reactivation 265.43 11.89 203 456788 2934 63029097
Rhabdomyolysis 261.96 11.89 13 456978 43938 62988093
Blood cholesterol increased 258.03 11.89 1348 455643 92684 62939347
Rheumatic fever 257.85 11.89 789 456202 42322 62989709
Muscle spasms 257.08 11.89 456 456535 155694 62876337
Hypoglycaemia 255.99 11.89 59 456932 60006 62972025
Inappropriate schedule of product administration 253.24 11.89 225 456766 103740 62928291
Throat irritation 251.86 11.89 717 456274 36930 62995101
Blood pressure systolic abnormal 247.54 11.89 387 456604 12999 63019032
Vision blurred 245 11.89 182 456809 91742 62940289
Cardio-respiratory arrest 238.07 11.89 68 456923 59891 62972140
Electrocardiogram QT prolonged 237.31 11.89 67 456924 59463 62972568
Death 235.11 11.89 1653 455338 372728 62659303
Inflammation 232.35 11.89 1189 455802 81084 62950947
International normalised ratio increased 231.95 11.89 30 456961 46395 62985636
Cardiac arrest 230.60 11.89 196 456795 92349 62939682
Asthenia 229.66 11.89 1717 455274 381887 62650144
Gastrooesophageal reflux disease 228.14 11.89 211 456780 95428 62936603
Swollen joint count increased 228.03 11.89 673 456318 35381 62996650
Psoriatic arthropathy 226.78 11.89 1276 455715 90244 62941787
Bradycardia 223.83 11.89 124 456867 73103 62958928
Pulmonary fibrosis 220.98 11.89 710 456281 39099 62992932
Hospitalisation 220.93 11.89 173 456818 84908 62947123
Urinary tract infection 219.22 11.89 1069 455922 263615 62768416
Agitation 217.39 11.89 79 456912 59678 62972353
Bone erosion 215.43 11.89 426 456565 17291 63014740
Incorrect dose administered 215.26 11.89 81 456910 59887 62972144
Product use in unapproved indication 214.66 11.89 2100 454891 176980 62855051
Panniculitis 214.50 11.89 332 456659 11053 63020978
Hypotension 213.27 11.89 1123 455868 271481 62760550
Injection site swelling 212.39 11.89 42 456949 47530 62984501
Sedation 209.35 11.89 19 456972 38790 62993241
Folliculitis 208.26 11.89 1030 455961 69287 62962744
Haematochezia 206.61 11.89 64 456927 53480 62978551
Knee arthroplasty 205.38 11.89 854 456137 53352 62978679
Hallucination 203.63 11.89 70 456921 54747 62977284
Muscle injury 202.73 11.89 970 456021 64375 62967656
Sleep disorder due to general medical condition, insomnia type 201.25 11.89 827 456164 51390 62980641
Drug tolerance decreased 200.36 11.89 410 456581 17063 63014968
Abdominal pain 200.02 11.89 1264 455727 292192 62739839
Type 2 diabetes mellitus 196.64 11.89 946 456045 62922 62969109
Hyperkalaemia 196.59 11.89 72 456919 54131 62977900
Disease progression 195.71 11.89 1533 455458 121225 62910806
Metabolic acidosis 194.60 11.89 43 456948 45026 62987005
Ear pruritus 193.09 11.89 187 456804 3778 63028253
Anaemia 192.31 11.89 1279 455712 292151 62739880
Cytomegalovirus infection 191.76 11.89 449 456542 20503 63011528
Injection site pruritus 190.89 11.89 45 456946 45071 62986960
Blood parathyroid hormone decreased 190.77 11.89 290 456701 9501 63022530
Granuloma skin 190.64 11.89 268 456723 8169 63023862
Hypokalaemia 182.00 11.89 291 456700 103513 62928518
COVID-19 pneumonia 181.71 11.89 349 456642 13860 63018171
Irritable bowel syndrome 179.00 11.89 1110 455881 81302 62950729
Liver injury 175.31 11.89 881 456110 59639 62972392
B-lymphocyte count decreased 174.87 11.89 105 456886 989 63031042
Cerebrovascular accident 173.68 11.89 320 456671 107704 62924327
Myocardial infarction 172.35 11.89 283 456708 99610 62932421
Back pain 171.22 11.89 1155 455836 262990 62769041
Diffuse large B-cell lymphoma refractory 168.51 11.89 107 456884 1123 63030908
Lactic acidosis 166.38 11.89 36 456955 38251 62993780
Blood pressure systolic increased 165.87 11.89 729 456262 46668 62985363
Intentional self-injury 165.60 11.89 4 456987 25683 63006348
Coma 164.42 11.89 133 456858 64231 62967800
Intentional product misuse 164.39 11.89 119 456872 60798 62971233
Lymphoma 164.10 11.89 306 456685 11881 63020150
Plasma cell myeloma 163.90 11.89 30 456961 35875 62996156
Unresponsive to stimuli 163.86 11.89 24 456967 33792 62998239
Balance disorder 163.30 11.89 221 456770 84201 62947830
Dry skin 163.04 11.89 104 456887 56783 62975248
Foot deformity 162.12 11.89 505 456486 27348 63004683
Gastrointestinal haemorrhage 161.62 11.89 208 456783 80968 62951063
Emotional distress 160.29 11.89 22 456969 32527 62999504
Pneumocystis jirovecii pneumonia 159.77 11.89 367 456624 16547 63015484
Blood glucose increased 158.25 11.89 223 456768 83533 62948498
Multiple sclerosis relapse 157.19 11.89 76 456915 48402 62983629
Therapy cessation 156.28 11.89 18 456973 30439 63001592
Flatulence 156.25 11.89 30 456961 34672 62997359
Swelling face 156.20 11.89 136 456855 63339 62968692
Therapy interrupted 155.04 11.89 24 456967 32431 62999600
Serum sickness 154.77 11.89 143 456848 2717 63029314
Blister 154.35 11.89 1520 455471 128294 62903737
Respiratory arrest 154.01 11.89 25 456966 32620 62999411
Tumour lysis syndrome 153.99 11.89 251 456740 8739 63023292
Orthostatic hypotension 153.12 11.89 36 456955 36124 62995907
Post transplant lymphoproliferative disorder 152.96 11.89 185 456806 4846 63027185
Demyelination 150.73 11.89 216 456775 6704 63025327
Therapeutic response decreased 150.51 11.89 855 456136 60670 62971361
Dysgeusia 150.28 11.89 74 456917 46636 62985395
Dyskinesia 147.68 11.89 26 456965 31976 63000055
Therapeutic product effect incomplete 147.08 11.89 1461 455530 123595 62908436
Decreased appetite 147.05 11.89 1130 455861 249922 62782109
Surgery 145.79 11.89 39 456952 35873 62996158
Impaired healing 144.81 11.89 1246 455745 101296 62930735
Therapy non-responder 144.49 11.89 989 456002 74912 62957119
Skin necrosis 143.32 11.89 313 456678 13637 63018394
Device issue 141.83 11.89 7 456984 23774 63008257
Product quality issue 141.77 11.89 41 456950 35824 62996207
Coeliac disease 141.69 11.89 296 456695 12501 63019530
Hepatitis B 140.84 11.89 155 456836 3657 63028374
Mobility decreased 140.32 11.89 1411 455580 119748 62912283
Humoral immune defect 135.17 11.89 56 456935 209 63031822
Tachycardia 135.06 11.89 419 456572 117737 62914294
Rectal haemorrhage 134.63 11.89 94 456897 48936 62983095
Insomnia 134.59 11.89 951 456040 214301 62817730
Epistaxis 134.06 11.89 197 456794 72528 62959503
Accidental exposure to product 133.83 11.89 19 456972 27386 63004645
Joint stiffness 133.83 11.89 627 456364 41242 62990789
Lethargy 133.03 11.89 124 456867 55883 62976148
Accidental overdose 132.48 11.89 9 456982 23300 63008731
Paraesthesia 132.12 11.89 630 456361 156336 62875695
Headache 131.12 11.89 3514 453477 629727 62402304
Injection site bruising 130.94 11.89 69 456922 41841 62990190
Palpitations 130.25 11.89 398 456593 112372 62919659
Blood calcium decreased 129.97 11.89 18 456973 26433 63005598
Renal failure 128.35 11.89 426 456565 117226 62914805
Depression 127.84 11.89 858 456133 195634 62836397
JC virus infection 127.71 11.89 111 456880 1940 63030091
Sopor 127.62 11.89 8 456983 22156 63009875
Full blood count abnormal 125.84 11.89 36 456955 31681 63000350
Deformity 123.28 11.89 265 456726 11419 63020612
Injection site haemorrhage 123.19 11.89 15 456976 24299 63007732
Vertigo 122.81 11.89 150 456841 59737 62972294
Condition aggravated 122.75 11.89 3775 453216 398442 62633589
Immunodeficiency 121.38 11.89 371 456620 19883 63012148
Disorientation 120.27 11.89 67 456924 39385 62992646
Ulcer 119.78 11.89 437 456554 25670 63006361
Musculoskeletal deformity 118.23 11.89 103 456888 1806 63030225
Memory impairment 117.54 11.89 372 456619 103886 62928145
Irritability 116.80 11.89 41 456950 31653 63000378
Nightmare 116.58 11.89 5 456986 19189 63012842
Blood potassium decreased 116.15 11.89 80 456911 41946 62990085
Blood pressure diastolic decreased 115.31 11.89 393 456598 22313 63009718
Arthritis 114.65 11.89 1308 455683 114613 62917418
Neutropenia 114.59 11.89 1833 455158 173172 62858859
Injection site rash 113.91 11.89 5 456986 18804 63013227
Contrast media allergy 112.74 11.89 111 456880 2290 63029741
Hypophagia 112.54 11.89 42 456949 31217 63000814
Grip strength decreased 112.52 11.89 385 456606 21902 63010129
Chest pain 111.91 11.89 1004 455987 214955 62817076
Skin exfoliation 111.42 11.89 88 456903 43014 62989017
Disturbance in attention 110.56 11.89 69 456922 38120 62993911
Hyperglycaemia 110.10 11.89 84 456907 41783 62990248
Sciatica 109.69 11.89 514 456477 33810 62998221
Disease recurrence 109.61 11.89 446 456545 27584 63004447
Chronic obstructive pulmonary disease 109.60 11.89 176 456815 62510 62969521
Osteonecrosis of jaw 109.47 11.89 58 456933 35065 62996966
Haematemesis 107.60 11.89 42 456949 30370 63001661
Neuropathy peripheral 106.64 11.89 438 456553 113229 62918802
Loss of consciousness 106.60 11.89 462 456529 117659 62914372
Basal cell carcinoma 106.01 11.89 441 456550 27550 63004481
Palmar-plantar erythrodysaesthesia syndrome 105.54 11.89 19 456972 22996 63009035
Cytopenia 105.49 11.89 248 456743 11353 63020678
Chronic kidney disease 104.91 11.89 103 456888 45295 62986736
Abdominal distension 104.85 11.89 299 456692 86316 62945715
Abdominal pain upper 104.68 11.89 965 456026 205479 62826552
Generalised tonic-clonic seizure 104.44 11.89 39 456952 28977 63003054
Cellulitis 104.39 11.89 276 456715 81682 62950349
Macular degeneration 103.74 11.89 24 456967 24352 63007679
Injection site mass 103.74 11.89 8 456983 18648 63013383
Blood bilirubin increased 103.58 11.89 70 456921 37070 62994961
Frequent bowel movements 103.44 11.89 20 456971 23002 63009029
Blood creatine phosphokinase increased 102.85 11.89 45 456946 30385 63001646
Malaise 102.12 11.89 2249 454742 413705 62618326
Swollen tongue 101.96 11.89 62 456929 34738 62997293
Haematotoxicity 101.63 11.89 215 456776 9161 63022870
COVID-19 101.62 11.89 1253 455738 111850 62920181
Product substitution issue 101.21 11.89 3 456988 15993 63016038
Restlessness 100.43 11.89 43 456948 29410 63002621
SLE arthritis 100.23 11.89 62 456929 619 63031412
Cognitive disorder 100.15 11.89 154 456837 55661 62976370
B-cell lymphoma recurrent 99.79 11.89 52 456939 361 63031670
Abnormal behaviour 99.76 11.89 17 456974 21409 63010622
Withdrawal syndrome 99.70 11.89 13 456978 19984 63012047
Chronic lymphocytic leukaemia recurrent 99.48 11.89 44 456947 200 63031831
Metastases to liver 99.17 11.89 24 456967 23615 63008416
Lower respiratory tract infection 98.66 11.89 1417 455574 130890 62901141
Product prescribing error 98.62 11.89 33 456958 26256 63005775
Angioedema 98.49 11.89 120 456871 47845 62984186
Mental status changes 98.45 11.89 84 456907 39515 62992516
Elbow deformity 98.41 11.89 84 456907 1431 63030600
Smooth muscle cell neoplasm 97.73 11.89 66 456925 775 63031256
Illness 97.33 11.89 126 456865 48933 62983098
Epstein-Barr virus infection 97.19 11.89 193 456798 7857 63024174
Cytomegalovirus viraemia 97.13 11.89 158 456833 5491 63026540
Full blood count decreased 97.05 11.89 33 456958 25991 63006040
Myelodysplastic syndrome 96.79 11.89 303 456688 16451 63015580
Creatinine renal clearance decreased 96.62 11.89 5 456986 16303 63015728
Therapy partial responder 96 11.89 227 456764 10431 63021600
Pulmonary oedema 95.99 11.89 154 456837 54719 62977312
Unevaluable event 94.90 11.89 139 456852 51247 62980784
Pulmonary hypertension 94.44 11.89 77 456914 37046 62994985
Coronary artery disease 94.42 11.89 58 456933 32319 62999712
Speech disorder 94.09 11.89 92 456899 40537 62991494
Hypoxia 93.54 11.89 180 456811 59612 62972419
Red blood cell sedimentation rate 93.47 11.89 143 456848 4711 63027320
Device malfunction 93.01 11.89 10 456981 17847 63014184
Metastases to bone 90.84 11.89 20 456971 20999 63011032
Aggression 90.80 11.89 28 456963 23470 63008561
Secondary immunodeficiency 90.48 11.89 77 456914 1306 63030725
Pallor 90.20 11.89 54 456937 30514 63001517
Staphylococcal bacteraemia 90.15 11.89 151 456840 5379 63026652
Diabetic ketoacidosis 89.66 11.89 19 456972 20486 63011545
Foetal exposure during pregnancy 89.45 11.89 60 456931 31902 63000129
No adverse event 88.81 11.89 556 456435 40849 62991182
Migraine 88.57 11.89 412 456579 102934 62929097
Diffuse large B-cell lymphoma 88.46 11.89 167 456824 6545 63025486
Caesarean section 87.55 11.89 10 456981 17022 63015009
Skin ulcer 87.38 11.89 570 456421 42475 62989556
Device dislocation 86.90 11.89 38 456953 25667 63006364
Obstructive airways disorder 86.86 11.89 21 456970 20678 63011353
Abortion spontaneous 86.82 11.89 128 456863 47067 62984964
Physical disability 86.74 11.89 103 456888 2645 63029386
Onychomycosis 86.11 11.89 182 456809 7750 63024281
Syncope 85.39 11.89 495 456496 116890 62915141
Depressed mood 85.25 11.89 98 456893 40093 62991938
Mental disorder 84.99 11.89 40 456951 25879 63006152
Joint range of motion decreased 84.86 11.89 459 456532 31969 63000062
Drug level increased 84.49 11.89 29 456962 22707 63009324
Urinary incontinence 84.48 11.89 64 456927 31950 63000081
Hallucination, visual 84.14 11.89 18 456973 19280 63012751
Obliterative bronchiolitis 84.09 11.89 89 456902 2006 63030025
Head injury 82.82 11.89 47 456944 27349 63004682
Drug reaction with eosinophilia and systemic symptoms 82.63 11.89 73 456918 33763 62998268
Blood alkaline phosphatase increased 82.54 11.89 113 456878 42854 62989177
Dysarthria 82.38 11.89 112 456879 42599 62989432
Transient ischaemic attack 82.33 11.89 90 456901 37663 62994368
Peripheral swelling 82.04 11.89 2500 454491 263442 62768589
Urinary retention 81.99 11.89 59 456932 30242 63001789
Product storage error 81.53 11.89 7 456984 14949 63017082
Burning sensation 81.49 11.89 168 456823 54239 62977792
Hypervolaemia 81.33 11.89 52 456939 28361 63003670
Haemoglobin decreased 81.30 11.89 663 456328 144822 62887209
Adverse event 80.21 11.89 791 456200 66768 62965263
Anaphylactic reaction 79.98 11.89 777 456214 65323 62966708
Hyperhidrosis 79.91 11.89 452 456539 107384 62924647
Labelled drug-drug interaction medication error 79.72 11.89 4 456987 13395 63018636
Lip swelling 79.56 11.89 64 456927 30999 63001032
White blood cell count abnormal 79.42 11.89 153 456838 6089 63025942
Hallucination, auditory 79.04 11.89 3 456988 12821 63019210
Injection site urticaria 78.35 11.89 6 456985 14067 63017964
Hepatic function abnormal 78.31 11.89 91 456900 37051 62994980
Chest discomfort 78.25 11.89 467 456524 109502 62922529
Jaundice 77.80 11.89 58 456933 29193 63002838
Hypomagnesaemia 77.70 11.89 56 456935 28681 63003350
Product administration error 77.49 11.89 32 456959 22365 63009666
Tenosynovitis 77.41 11.89 247 456744 13548 63018483
Blood immunoglobulin M decreased 77.21 11.89 61 456930 927 63031104
Blood sodium decreased 77.13 11.89 39 456952 24213 63007818
Stomatitis 76.99 11.89 1415 455576 137310 62894721
Fibromyalgia 76.62 11.89 901 456090 79519 62952512
Pulmonary toxicity 76.25 11.89 193 456798 9262 63022769
Cholelithiasis 76.15 11.89 124 456867 43801 62988230
Injection site warmth 75.46 11.89 10 456981 15185 63016846
Therapeutic response unexpected 74.96 11.89 21 456970 18738 63013293
Asthma 74.20 11.89 575 456416 126986 62905045
Adjustment disorder with depressed mood 73.81 11.89 200 456791 10004 63022027
Red blood cell sedimentation rate abnormal 73.60 11.89 310 456681 19472 63012559
Abdominal pain lower 73.49 11.89 47 456944 25631 63006400
Pulmonary embolism 73.12 11.89 515 456476 116169 62915862
Oxygen saturation decreased 73.03 11.89 966 456025 87619 62944412
Extrapyramidal disorder 73.02 11.89 6 456985 13278 63018753
Haematoma 72.67 11.89 86 456905 34734 62997297
Device difficult to use 72.55 11.89 5 456986 12791 63019240
Surgical failure 71.99 11.89 58 456933 908 63031123
Hypersomnia 70.70 11.89 21 456970 18034 63013997
Blood urea increased 70.55 11.89 52 456939 26327 63005704
Pancreatitis 70.53 11.89 155 456836 48900 62983131
Aspergillus infection 70.34 11.89 170 456821 7923 63024108
Nasal congestion 70.04 11.89 240 456751 65420 62966611
Nervousness 69.62 11.89 72 456919 30907 63001124
Hyperlipidaemia 69.28 11.89 27 456964 19544 63012487
Sleep apnoea syndrome 68.59 11.89 65 456926 29068 63002963
Joint destruction 68.50 11.89 144 456847 6108 63025923
Visual acuity reduced 68.08 11.89 36 456955 21790 63010241
Polyomavirus-associated nephropathy 68.03 11.89 75 456916 1773 63030258
Prescribed overdose 67.95 11.89 450 456541 33703 62998328
Vascular access complication 67.87 11.89 80 456911 2038 63029993
Disability 67.86 11.89 287 456704 18060 63013971
Red cell distribution width decreased 67.84 11.89 79 456912 1986 63030045
Blood pressure decreased 67.79 11.89 240 456751 64782 62967249
Right ventricular failure 67.29 11.89 20 456971 17168 63014863
Deep vein thrombosis 67.21 11.89 342 456649 83458 62948573
Influenza like illness 66.80 11.89 251 456740 66573 62965458
Osteoarthritis 66.68 11.89 1010 455981 94333 62937698
Dystonia 66.51 11.89 10 456981 13809 63018222
Tubulointerstitial nephritis 66.37 11.89 30 456961 19873 63012158
Dislocation of vertebra 66.26 11.89 173 456818 8462 63023569
Bronchitis chronic 65.87 11.89 115 456876 4238 63027793
General physical health deterioration 65.79 11.89 1907 455084 199495 62832536
Temperature regulation disorder 65.75 11.89 140 456851 5992 63026039
Procedural pain 65.21 11.89 37 456954 21532 63010499
Mean platelet volume decreased 65.14 11.89 88 456903 2581 63029450
Vaginal haemorrhage 65.10 11.89 61 456930 27426 63004605
Pollakiuria 64.99 11.89 63 456928 27874 63004157
Spinal column injury 64.95 11.89 77 456914 1974 63030057
Transfusion 64.72 11.89 15 456976 15202 63016829
Dyspnoea exertional 64.60 11.89 220 456771 60082 62971949
Herpes zoster 64.59 11.89 891 456100 81571 62950460
Chromaturia 64.45 11.89 20 456971 16697 63015334
Complication associated with device 64.23 11.89 21 456970 16957 63015074
Pneumonia aspiration 64.20 11.89 93 456898 34447 62997584
Cardiac disorder 64.04 11.89 172 456819 50644 62981387
Cardiac failure 63.70 11.89 378 456613 88764 62943267
Psoriasis 63.60 11.89 366 456625 86591 62945440
Acute myocardial infarction 63.21 11.89 83 456908 32041 62999990
Seronegative arthritis 63.07 11.89 107 456884 3852 63028179
Hypercalcaemia 63.05 11.89 384 456607 27938 63004093
Sleep disorder 62.95 11.89 879 456112 80687 62951344
Agranulocytosis 62.58 11.89 351 456640 24783 63007248
Poor quality sleep 62.00 11.89 33 456958 19902 63012129
Rash papular 61.96 11.89 18 456973 15684 63016347
Impaired quality of life 61.87 11.89 12 456979 13771 63018260
Myelosuppression 61.68 11.89 335 456656 23368 63008663
Dysuria 61.57 11.89 92 456899 33646 62998385
Pulmonary arterial hypertension 61.04 11.89 44 456947 22533 63009498
Drug ineffective for unapproved indication 60.78 11.89 437 456554 33626 62998405
Dermatitis contact 60.43 11.89 5 456986 11003 63021028
Toxic epidermal necrolysis 60.26 11.89 56 456935 25278 63006753
Melaena 60.22 11.89 78 456913 30287 63001744
Cough 60.18 11.89 1625 455366 291118 62740913
Breast cancer stage III 60.14 11.89 188 456803 10198 63021833
Electric shock 60.08 11.89 60 456931 1260 63030771
Panic attack 59.75 11.89 44 456947 22287 63009744
Cardiomegaly 59.60 11.89 26 456965 17588 63014443
Myoclonus 59.38 11.89 20 456971 15848 63016183
Malignant neoplasm progression 59.33 11.89 347 456644 81774 62950257
Cytomegalovirus infection reactivation 59.07 11.89 104 456887 3859 63028172
Pancreatitis acute 58.97 11.89 65 456926 27101 63004930
Sinus bradycardia 58.68 11.89 16 456975 14535 63017496
Infusion site reaction 58.54 11.89 98 456893 3489 63028542
Lymphoma transformation 58.38 11.89 27 456964 139 63031892
Eye pain 58.28 11.89 96 456895 33758 62998273
Sleep disorder due to a general medical condition 58.24 11.89 9 456982 12179 63019852
Bone swelling 57.53 11.89 66 456925 1632 63030399
Psychotic disorder 57.51 11.89 60 456931 25652 63006379
Altered state of consciousness 57.42 11.89 58 456933 25172 63006859
Eczema 57.06 11.89 90 456901 32201 62999830
Mantle cell lymphoma recurrent 56.91 11.89 29 456962 191 63031840
Skin discolouration 56.48 11.89 117 456874 37711 62994320
Seasonal allergy 56.41 11.89 41 456950 20909 63011122
Needle issue 56.17 11.89 5 456986 10371 63021660
Cholecystitis chronic 56.07 11.89 5 456986 10356 63021675
Haematocrit decreased 55.98 11.89 125 456866 39215 62992816
Blood potassium increased 55.94 11.89 31 456960 18278 63013753
Musculoskeletal disorder 55.92 11.89 295 456696 20349 63011682
Gastrointestinal disorder 55.79 11.89 1287 455704 129952 62902079
Liver function test increased 55.72 11.89 416 456575 32395 62999636
Faeces discoloured 55.60 11.89 32 456959 18477 63013554
Coagulopathy 55.59 11.89 40 456951 20504 63011527
Respiratory depression 55.46 11.89 15 456976 13700 63018331
Hypocalcaemia 55.46 11.89 89 456902 31624 63000407
Blood immunoglobulin G decreased 55.42 11.89 78 456913 2380 63029651
Product label confusion 55.39 11.89 67 456924 1755 63030276
Gamma-glutamyltransferase increased 55.39 11.89 100 456891 33931 62998100
Circulatory collapse 55.19 11.89 46 456945 21892 63010139
Tinnitus 55.08 11.89 108 456883 35520 62996511
Pre-existing disease 54.90 11.89 27 456964 163 63031868
Pelvic pain 54.27 11.89 15 456976 13504 63018527
Bronchitis 54.18 11.89 606 456385 124329 62907702
Parkinsonism 53.98 11.89 6 456985 10433 63021598
Ventricular tachycardia 53.93 11.89 39 456952 19940 63012091
Fear 53.78 11.89 23 456968 15743 63016288
Monocyte count increased 53.34 11.89 146 456845 7347 63024684
Wrist deformity 53.16 11.89 71 456920 2059 63029972
Mania 52.98 11.89 12 456979 12355 63019676
Meningoencephalitis viral 52.89 11.89 32 456959 306 63031725
Drug eruption 52.87 11.89 371 456620 28323 63003708
Stevens-Johnson syndrome 52.74 11.89 61 456930 24889 63007142
Gastritis 52.69 11.89 119 456872 37184 62994847
Blood glucose decreased 52.62 11.89 44 456947 20908 63011123
Blood loss anaemia 52.58 11.89 3 456988 8998 63023033
Infusion site pain 52.35 11.89 28 456963 16841 63015190
Incorrect product administration duration 51.94 11.89 10 456981 11536 63020495
Ageusia 51.90 11.89 17 456974 13711 63018320
X-ray abnormal 51.85 11.89 152 456839 7958 63024073
Musculoskeletal pain 51.79 11.89 943 456048 91334 62940697
Metastases to central nervous system 51.76 11.89 15 456976 13090 63018941
Anger 51.56 11.89 13 456978 12443 63019588
Lung disorder 51.33 11.89 679 456312 61582 62970449
Hip fracture 51.28 11.89 83 456908 29391 63002640
Cerebral toxoplasmosis 51.19 11.89 48 456943 930 63031101
Femur fracture 50.63 11.89 144 456847 41612 62990419
Nodule 50.61 11.89 291 456700 20735 63011296
Sinus tachycardia 50.58 11.89 60 456931 24208 63007823
Laryngeal disorder 50.47 11.89 49 456942 993 63031038
Intestinal obstruction 50.11 11.89 91 456900 30808 63001223
Therapy responder 49.91 11.89 31 456960 312 63031719
Device breakage 49.84 11.89 11 456980 11531 63020500
Torsade de pointes 49.66 11.89 17 456974 13334 63018697
Rash macular 49.52 11.89 57 456934 23307 63008724
Premature baby 49.12 11.89 46 456945 20689 63011342
Ascites 48.98 11.89 141 456850 40587 62991444
Pleural effusion 48.81 11.89 432 456559 92778 62939253
Mean cell volume decreased 48.78 11.89 96 456895 3882 63028149
Fluid retention 48.76 11.89 242 456749 59444 62972587
Diverticulum 48.71 11.89 13 456978 11978 63020053
Varicella zoster virus infection 48.68 11.89 77 456914 2612 63029419
Nasopharyngitis 48.64 11.89 2267 454724 251990 62780041
Anuria 48.42 11.89 15 456976 12536 63019495
Bone marrow failure 48.41 11.89 369 456622 28921 63003110
Acidosis 47.92 11.89 11 456980 11222 63020809
Face oedema 47.69 11.89 45 456946 20167 63011864
Pruritus 47.69 11.89 2121 454870 359332 62672699
Gastric disorder 47.54 11.89 444 456547 36925 62995106
Haemophagocytic lymphohistiocytosis 47.16 11.89 176 456815 10451 63021580
Rhinitis allergic 47.10 11.89 13 456978 11714 63020317
Fine motor skill dysfunction 47.01 11.89 106 456885 4719 63027312
Mydriasis 46.64 11.89 14 456977 11942 63020089
Haemodialysis 46.63 11.89 5 456986 8942 63023089
Hypokinesia 46.48 11.89 21 456970 13915 63018116
Anticipatory anxiety 46.45 11.89 51 456940 1200 63030831
Cytokine release syndrome 46.20 11.89 215 456776 14099 63017932
Feeling hot 45.98 11.89 196 456795 50158 62981873
Electrolyte imbalance 45.86 11.89 46 456945 20030 63012001
Eye swelling 45.84 11.89 63 456928 23855 63008176
Mitral valve incompetence 45.79 11.89 44 456947 19550 63012481
Joint dislocation 45.78 11.89 261 456730 18539 63013492
Anaphylactic shock 45.55 11.89 62 456929 23571 63008460
Hepatitis E 45.38 11.89 54 456937 1390 63030641
Mood altered 44.98 11.89 25 456966 14718 63017313
Haemorrhoids 44.86 11.89 56 456935 22094 63009937
Glomerulonephritis 44.77 11.89 60 456931 1746 63030285
Ankle arthroplasty 44.59 11.89 60 456931 1753 63030278
Weight decreased 44.54 11.89 1587 455404 275211 62756820
Deep vein thrombosis postoperative 44.52 11.89 181 456810 11188 63020843
Systemic lupus erythematosus rash 44.29 11.89 67 456924 2185 63029846
Rhinorrhoea 44.28 11.89 283 456708 65294 62966737
Pericardial effusion 44.01 11.89 94 456897 29964 63002067
Oesophagitis 43.60 11.89 27 456964 14981 63017050
Delusion 43.50 11.89 16 456975 12001 63020030
Hysterectomy 43.21 11.89 8 456983 9491 63022540
Episcleritis 42.86 11.89 44 456947 956 63031075
B-cell lymphoma refractory 42.85 11.89 19 456972 87 63031944
Complication of device insertion 42.75 11.89 3 456988 7561 63024470
Hospice care 42.46 11.89 4 456987 7928 63024103
Drug level decreased 42.38 11.89 4 456987 7915 63024116
Muscle rigidity 42.16 11.89 15 456976 11485 63020546
Dementia 41.87 11.89 44 456947 18750 63013281
Lipase increased 41.63 11.89 10 456981 9890 63022141
Prothrombin time prolonged 41.53 11.89 9 456982 9555 63022476
Dizziness postural 41.48 11.89 3 456988 7373 63024658
Mesenteritis 41.46 11.89 27 456964 297 63031734
Blood triglycerides increased 41.37 11.89 19 456972 12469 63019562
Breast cancer female 41.36 11.89 23 456968 13536 63018495
Metastases to lung 41.31 11.89 20 456971 12730 63019301
Genital haemorrhage 41.18 11.89 3 456988 7329 63024702
Confusional state 41.11 11.89 1342 455649 235038 62796993
Arthrodesis 41.09 11.89 73 456918 2728 63029303
Finger deformity 41.04 11.89 136 456855 7609 63024422
Cerebral haemorrhage 41.03 11.89 101 456890 30628 63001403
Acute respiratory failure 41.02 11.89 120 456871 34365 62997666
Mean cell haemoglobin decreased 41.02 11.89 105 456886 5074 63026957
Prescribed underdose 40.95 11.89 359 456632 29330 63002701
Haemorrhage 40.87 11.89 264 456727 60758 62971273
West Nile viral infection 40.80 11.89 29 456962 372 63031659
Skin irritation 40.64 11.89 10 456981 9731 63022300
Hypercholesterolaemia 40.58 11.89 278 456713 21056 63010975
Post procedural complication 40.30 11.89 38 456953 17036 63014995
Heavy menstrual bleeding 40.28 11.89 41 456950 17732 63014299
Haemoptysis 40.28 11.89 92 456899 28634 63003397
Breast cancer metastatic 40.25 11.89 18 456973 12000 63020031
Upper gastrointestinal haemorrhage 39.94 11.89 46 456945 18806 63013225
Posterior reversible encephalopathy syndrome 39.77 11.89 237 456754 17108 63014923
Colitis ulcerative 39.55 11.89 80 456911 26011 63006020
Dysphonia 39.50 11.89 192 456799 47422 62984609
Electrocardiogram abnormal 39.13 11.89 9 456982 9170 63022861
Adenovirus infection 38.83 11.89 82 456909 3489 63028542
Eosinophil count increased 38.81 11.89 15 456976 10913 63021118
Peptic ulcer haemorrhage 38.72 11.89 43 456948 1025 63031006
Hot flush 38.66 11.89 213 456778 50946 62981085
Retinitis 38.54 11.89 115 456876 6081 63025950
Immunoglobulins decreased 38.45 11.89 47 456944 1245 63030786
Visual impairment 38.45 11.89 405 456586 84041 62947990
Renal disorder 38.31 11.89 116 456875 32858 62999173
Acquired haemophilia 38.22 11.89 42 456949 989 63031042
Ocular hyperaemia 38.19 11.89 77 456914 25067 63006964
Pneumocystis jirovecii infection 37.86 11.89 50 456941 1434 63030597
Onychomadesis 37.86 11.89 110 456881 5730 63026301
Heart rate decreased 37.60 11.89 497 456494 45063 62986968
Eating disorder 37.55 11.89 49 456942 18967 63013064
Second primary malignancy 37.22 11.89 134 456857 7819 63024212
Eye pruritus 36.98 11.89 48 456943 18623 63013408
Ventricular extrasystoles 36.86 11.89 19 456972 11668 63020363
Blood lactic acid increased 36.83 11.89 4 456987 7082 63024949
Apathy 36.75 11.89 9 456982 8785 63023246
Nocturia 36.73 11.89 7 456984 8134 63023897
Encephalopathy 36.71 11.89 148 456843 38472 62993559
Blood iron abnormal 36.49 11.89 84 456907 3792 63028239
Retching 36.48 11.89 31 456960 14614 63017417
Blood calcium increased 36.38 11.89 11 456980 9339 63022692
Vasculitis 36.26 11.89 240 456751 17969 63014062
Cystitis haemorrhagic 36.25 11.89 87 456904 4036 63027995
Major depression 35.95 11.89 7 456984 8011 63024020
Dialysis 35.91 11.89 15 456976 10412 63021619
Product complaint 35.90 11.89 24 456967 12785 63019246
Central nervous system lymphoma 35.86 11.89 49 456942 1453 63030578
Blood pressure diastolic increased 35.80 11.89 155 456836 9855 63022176
Concussion 35.74 11.89 11 456980 9233 63022798
Back injury 35.64 11.89 151 456840 9509 63022522
Atrioventricular block first degree 35.61 11.89 5 456986 7268 63024763
Dysstasia 35.53 11.89 61 456930 21105 63010926
Small intestinal obstruction 35.44 11.89 48 456943 18289 63013742
Soft tissue disorder 35.38 11.89 90 456901 4332 63027699
Sensory disturbance 35.22 11.89 28 456963 13644 63018387
Head discomfort 35.16 11.89 27 456964 13388 63018643
Cyanosis 35.15 11.89 42 456949 16893 63015138
Renal injury 35.14 11.89 12 456979 9427 63022604
Urine output decreased 35.10 11.89 19 456972 11351 63020680
Breast pain 34.87 11.89 10 456981 8788 63023243
Blood lactate dehydrogenase increased 34.78 11.89 285 456706 22831 63009200
Cardiogenic shock 34.60 11.89 47 456944 17885 63014146
Epilepsy 34.56 11.89 91 456900 26974 63005057
Extra dose administered 34.54 11.89 3 456988 6347 63025684
Underdose 34.54 11.89 93 456898 27363 63004668
Bunion operation 34.43 11.89 45 456946 1277 63030754
Lupus vulgaris 34.25 11.89 108 456883 5886 63026145
Thinking abnormal 34.02 11.89 17 456974 10626 63021405
Epstein-Barr virus infection reactivation 34.00 11.89 35 456956 763 63031268
Infusion site erythema 33.94 11.89 21 456970 11658 63020373
Shock 33.83 11.89 74 456917 23389 63008642
Muscle spasticity 33.74 11.89 66 456925 21728 63010303
Infusion site swelling 33.73 11.89 14 456977 9756 63022275
Salivary hypersecretion 33.73 11.89 7 456984 7659 63024372
Gastrosplenic fistula 33.64 11.89 14 456977 53 63031978
Muscle strain 33.55 11.89 9 456982 8265 63023766
Thirst 33.44 11.89 31 456960 14010 63018021
Concomitant disease aggravated 33.21 11.89 12 456979 9100 63022931
Iron deficiency anaemia 33.11 11.89 58 456933 19911 63012120
Febrile bone marrow aplasia 33.08 11.89 122 456869 7203 63024828
Abdominal tenderness 32.89 11.89 9 456982 8157 63023874
Renal impairment 32.83 11.89 443 456548 87912 62944119
Subdural haematoma 32.53 11.89 33 456958 14295 63017736
Leukocytosis 32.51 11.89 88 456903 25847 63006184
Diplopia 32.46 11.89 77 456914 23651 63008380
Nasal polyps 32.45 11.89 3 456988 6036 63025995
Hepatic failure 32.43 11.89 139 456852 35517 62996514
Arteriosclerosis 32.29 11.89 16 456975 10050 63021981
Ankle operation 32.27 11.89 43 456948 1244 63030787
Angina unstable 32.22 11.89 6 456985 7089 63024942
Hyperthyroidism 31.97 11.89 35 456956 14638 63017393
Musculoskeletal chest pain 31.65 11.89 65 456926 21018 63011013
Eyelid oedema 31.64 11.89 18 456973 10461 63021570
Jaundice cholestatic 31.59 11.89 7 456984 7317 63024714
Colitis ischaemic 31.47 11.89 19 456972 10689 63021342
Drug use disorder 31.47 11.89 93 456898 4891 63027140
Fracture 31.46 11.89 58 456933 19526 63012505
Oral pruritus 31.44 11.89 58 456933 2233 63029798
Sputum discoloured 31.39 11.89 43 456948 16304 63015727
Thyroid neoplasm 31.33 11.89 81 456910 3938 63028093
Hypovolaemia 31.28 11.89 19 456972 10654 63021377
Micturition urgency 31.25 11.89 15 456976 9596 63022435
Nerve injury 31.08 11.89 148 456843 9798 63022233
Female genital tract fistula 31.08 11.89 8 456983 7551 63024480
Anti-cyclic citrullinated peptide antibody 30.89 11.89 113 456878 6645 63025386
Pulseless electrical activity 30.84 11.89 8 456983 7513 63024518
Wound infection 30.63 11.89 261 456730 21149 63010882
Bursitis 30.54 11.89 404 456587 36637 62995394
Taste disorder 30.42 11.89 32 456959 13630 63018401
Duodenal ulcer 30.40 11.89 9 456982 7747 63024284
Food allergy 30.25 11.89 162 456829 11239 63020792
Steroid diabetes 30.22 11.89 42 456949 1266 63030765
Eosinophilia 30.22 11.89 75 456916 22681 63009350
Campylobacter infection 30.19 11.89 38 456953 1038 63030993
Crying 30.18 11.89 78 456913 23265 63008766
Device leakage 30.17 11.89 7 456984 7089 63024942
Autoimmune haemolytic anaemia 30.15 11.89 87 456904 4514 63027517
Treatment noncompliance 30.10 11.89 152 456839 37173 62994858
Amenorrhoea 29.98 11.89 17 456974 9897 63022134
Flushing 29.92 11.89 371 456620 74716 62957315
Tongue disorder 29.91 11.89 153 456838 10427 63021604
Fatigue 29.85 11.89 7015 449976 881013 62151018
Respiratory acidosis 29.82 11.89 6 456985 6709 63025322
Renal tubular necrosis 29.76 11.89 25 456966 11853 63020178
Pain of skin 29.75 11.89 24 456967 11610 63020421
Tricuspid valve incompetence 29.57 11.89 37 456954 14584 63017447
Product dose omission in error 29.54 11.89 9 456982 7603 63024428
Bradyphrenia 29.45 11.89 7 456984 6973 63025058
Rheumatic disorder 29.39 11.89 67 456924 3005 63029026
Hyperbilirubinaemia 29.36 11.89 23 456968 11291 63020740
Presyncope 29.33 11.89 102 456889 27683 63004348
Facial pain 29.32 11.89 20 456971 10541 63021490
Interstitial lung disease 29.10 11.89 616 456375 61292 62970739
Babesiosis 29.10 11.89 19 456972 210 63031821
Gestational diabetes 29.04 11.89 12 456979 8384 63023647
Subarachnoid haemorrhage 29.04 11.89 36 456955 14247 63017784
Pharyngeal paraesthesia 29.01 11.89 52 456939 1957 63030074
Hypothermia 28.92 11.89 33 456958 13548 63018483
Breast cancer stage I 28.88 11.89 7 456984 6882 63025149
Autoimmune disorder 28.72 11.89 217 456774 16960 63015071
Aphasia 28.59 11.89 131 456860 32869 62999162
Infection reactivation 28.45 11.89 39 456952 1160 63030871
Initial insomnia 28.41 11.89 5 456986 6152 63025879
Respiratory failure 28.38 11.89 539 456452 101319 62930712
Blood creatinine increased 28.27 11.89 453 456538 87391 62944640
Intervertebral discitis 28.26 11.89 68 456923 3160 63028871
Glomerular filtration rate decreased 28.26 11.89 33 456958 13408 63018623
Walking aid user 28.24 11.89 152 456839 10565 63021466
Insurance issue 28.18 11.89 5 456986 6116 63025915
Premature labour 28.16 11.89 29 456962 12475 63019556
Ischaemic stroke 28.13 11.89 54 456937 17903 63014128
Dermatitis bullous 28.10 11.89 13 456978 8495 63023536
Sinus disorder 28.08 11.89 87 456904 24466 63007565
ADAMTS13 activity decreased 27.88 11.89 15 456976 112 63031919
Exostosis 27.84 11.89 222 456769 17640 63014391
Middle insomnia 27.72 11.89 30 456961 12613 63019418
Thrombosis 27.70 11.89 315 456676 64440 62967591
Allergy to chemicals 27.62 11.89 65 456926 2977 63029054
Oropharyngeal pain 27.57 11.89 496 456495 93991 62938040
Low density lipoprotein increased 27.57 11.89 6 456985 6351 63025680
Upper-airway cough syndrome 27.44 11.89 25 456966 11393 63020638
Nail disorder 27.42 11.89 174 456817 12841 63019190
Inappropriate antidiuretic hormone secretion 27.41 11.89 43 456948 15419 63016612
Polyomavirus viraemia 27.38 11.89 30 456961 704 63031327
Amnesia 27.20 11.89 262 456729 55323 62976708
Maternal drugs affecting foetus 27.14 11.89 3 456988 5239 63026792
Eructation 27.11 11.89 13 456978 8320 63023711
Blood immunoglobulin A decreased 27.07 11.89 40 456951 1277 63030754
Hypertension 27.00 11.89 2348 454643 276955 62755076
Oliguria 26.96 11.89 16 456975 9085 63022946
Secretion discharge 26.84 11.89 29 456962 12202 63019829
Bradykinesia 26.78 11.89 3 456988 5185 63026846
Ureaplasma infection 26.74 11.89 28 456963 623 63031408
Paraesthesia oral 26.73 11.89 62 456929 19194 63012837
Pain in extremity 26.69 11.89 2039 454952 329447 62702584
Hypoacusis 26.62 11.89 87 456904 24064 63007967
Lacrimation increased 26.62 11.89 69 456922 20562 63011469
Cholestasis 26.61 11.89 115 456876 29319 63002712
Myocardial ischaemia 26.58 11.89 32 456959 12827 63019204
Dysphagia 26.49 11.89 463 456528 88122 62943909
Premature delivery 26.35 11.89 120 456871 30161 63001870
Photosensitivity reaction 26.29 11.89 42 456949 14952 63017079
Blood albumin decreased 26.24 11.89 41 456950 14725 63017306
Groin pain 26.15 11.89 21 456970 10182 63021849
Red blood cell count decreased 26.13 11.89 178 456813 40467 62991564
Cholecystitis 26.10 11.89 44 456947 15333 63016698
Proctitis 26.04 11.89 4 456987 5437 63026594
Drug tolerance 25.93 11.89 109 456882 6840 63025191
Emotional disorder 25.88 11.89 35 456956 13344 63018687
Ear pain 25.88 11.89 153 456838 35965 62996066
Staphylococcal infection 25.87 11.89 182 456809 41074 62990957
Arteriosclerosis coronary artery 25.83 11.89 14 456977 8359 63023672
Essential hypertension 25.76 11.89 3 456988 5030 63027001
Vasogenic cerebral oedema 25.71 11.89 32 456959 864 63031167
Brain oedema 25.62 11.89 39 456952 14156 63017875
Amylase increased 25.54 11.89 7 456984 6338 63025693
Dermatitis acneiform 25.51 11.89 3 456988 4993 63027038
Hypomania 25.45 11.89 7 456984 6323 63025708
Device failure 25.42 11.89 6 456985 6005 63026026
Blood pressure inadequately controlled 25.39 11.89 3 456988 4975 63027056
Spinal operation 25.27 11.89 14 456977 8257 63023774
Muscle tightness 25.25 11.89 29 456962 11871 63020160
Influenza 25.12 11.89 593 456398 108129 62923902
Ventricular fibrillation 25.09 11.89 29 456962 11838 63020193
Atrial fibrillation 25.09 11.89 643 456348 115993 62916038
Sensitivity to weather change 25.07 11.89 111 456880 7126 63024905
Wheelchair user 25.06 11.89 101 456890 6218 63025813
Supraventricular tachycardia 25 11.89 40 456951 14231 63017800
Tumour marker increased 24.98 11.89 3 456988 4912 63027119
Faecaloma 24.91 11.89 13 456978 7928 63024103
Hypothyroidism 24.85 11.89 192 456799 42440 62989591
Intermenstrual bleeding 24.83 11.89 13 456978 7913 63024118
Euphoric mood 24.79 11.89 3 456988 4884 63027147
Facet joint syndrome 24.79 11.89 161 456830 11977 63020054
Cervix disorder 24.74 11.89 26 456965 581 63031450
Wrist surgery 24.70 11.89 31 456960 844 63031187
Chronic lymphocytic leukaemia transformation 24.70 11.89 11 456980 51 63031980
Scoliosis 24.62 11.89 13 456978 7875 63024156
Troponin increased 24.51 11.89 22 456969 10099 63021932
Lip dry 24.51 11.89 193 456798 15277 63016754
Choking 24.50 11.89 21 456970 9858 63022173
Bronchopulmonary aspergillosis 24.50 11.89 125 456866 8510 63023521
Hepatic steatosis 24.45 11.89 115 456876 28654 63003377
Cerebral infarction 24.36 11.89 89 456902 23804 63008227
Vaccination failure 24.35 11.89 29 456962 747 63031284
Drug dose omission by device 24.23 11.89 3 456988 4798 63027233
Exercise tolerance decreased 24.23 11.89 5 456986 5492 63026539
Spinal stenosis 24.16 11.89 44 456947 14881 63017150
Joint injury 24.16 11.89 322 456669 29250 63002781
Skin plaque 24.12 11.89 15 456976 8305 63023726
Proctalgia 24.12 11.89 7 456984 6103 63025928
Personality change 24.06 11.89 10 456981 6963 63025068
Product preparation error 24.01 11.89 7 456984 6085 63025946
Acute hepatitis B 24.01 11.89 20 456971 329 63031702
Abnormal loss of weight 24.00 11.89 6 456985 5776 63026255
Anovulatory cycle 23.98 11.89 15 456976 153 63031878
Eosinophilic cystitis 23.88 11.89 11 456980 56 63031975
Muscular weakness 23.85 11.89 684 456307 121669 62910362
Rib fracture 23.82 11.89 83 456908 22514 63009517
Intestinal sepsis 23.82 11.89 19 456972 293 63031738
Mixed liver injury 23.79 11.89 3 456988 4732 63027299
Cartilage atrophy 23.74 11.89 15 456976 156 63031875
Muscle twitching 23.71 11.89 68 456923 19600 63012431
Post procedural haemorrhage 23.59 11.89 14 456977 7950 63024081
Impaired gastric emptying 23.57 11.89 141 456850 10191 63021840
Mental impairment 23.55 11.89 41 456950 14110 63017921
Knee operation 23.53 11.89 7 456984 6006 63026025
Immunodeficiency common variable 23.47 11.89 17 456974 225 63031806
Atypical femur fracture 23.44 11.89 5 456986 5367 63026664
Hepatic necrosis 23.42 11.89 6 456985 5681 63026350
Neck deformity 23.41 11.89 49 456942 2072 63029959
Non-cardiac chest pain 23.30 11.89 8 456983 6264 63025767
Atelectasis 23.26 11.89 78 456913 21405 63010626
Bundle branch block left 22.98 11.89 11 456980 7048 63024983
Incontinence 22.94 11.89 30 456961 11602 63020429
Anal incontinence 22.90 11.89 39 456952 13537 63018494
Hereditary angioedema 22.82 11.89 13 456978 7549 63024482
Intentional dose omission 22.81 11.89 15 456976 8060 63023971
Heparin-induced thrombocytopenia 22.79 11.89 3 456988 4579 63027452
Hypotonia 22.71 11.89 20 456971 9265 63022766
Osteonecrosis 22.69 11.89 95 456896 24435 63007596
Compression fracture 22.65 11.89 9 456982 6439 63025592
Flank pain 22.65 11.89 53 456938 16357 63015674
Nephrogenic systemic fibrosis 22.62 11.89 3 456988 4553 63027478
Arrhythmia 22.59 11.89 171 456820 37969 62994062
Citrobacter bacteraemia 22.54 11.89 8 456983 17 63032014
Neck mass 22.53 11.89 67 456924 3536 63028495
Pancytopenia 22.48 11.89 882 456109 96051 62935980
Peripheral coldness 22.36 11.89 33 456958 12132 63019899
Drug level below therapeutic 22.35 11.89 4 456987 4862 63027169
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.16 11.89 58 456933 2841 63029190
Live birth 22.16 11.89 282 456709 25348 63006683
Application site erythema 22.15 11.89 4 456987 4831 63027200
Abnormal faeces 22.15 11.89 6 456985 5474 63026557
Skin lesion 22.08 11.89 130 456861 30591 63001440
Stress 22.07 11.89 345 456646 66822 62965209
Skin burning sensation 22.02 11.89 36 456955 12698 63019333
Metastases to lymph nodes 21.92 11.89 16 456975 8142 63023889
Enthesopathy 21.91 11.89 121 456870 8493 63023538
Injection site haematoma 21.71 11.89 11 456980 6821 63025210
Infusion site haemorrhage 21.66 11.89 5 456986 5081 63026950
Eye irritation 21.64 11.89 83 456908 21888 63010143
Pulse absent 21.50 11.89 6 456985 5368 63026663
Platelet count abnormal 21.46 11.89 63 456928 3301 63028730
Meningitis enteroviral 21.45 11.89 7 456984 10 63032021
Leukoerythroblastosis 21.40 11.89 16 456975 223 63031808
Aspiration 21.38 11.89 28 456963 10823 63021208
Potentiating drug interaction 21.32 11.89 3 456988 4353 63027678
Hyperreflexia 21.31 11.89 8 456983 5926 63026105
Granulocyte count increased 21.25 11.89 29 456962 859 63031172
Maternal exposure timing unspecified 21.10 11.89 104 456887 6983 63025048
Acne 21.06 11.89 91 456900 23202 63008829
Bladder disorder 21.01 11.89 20 456971 8926 63023105
Hiatus hernia 21 11.89 82 456909 21512 63010519
Malignant transformation 20.93 11.89 20 456971 397 63031634
Clear cell renal cell carcinoma 20.89 11.89 38 456953 1447 63030584
Wrong product administered 20.88 11.89 9 456982 6132 63025899
Hypoxic-ischaemic encephalopathy 20.87 11.89 3 456988 4284 63027747
Injection site discomfort 20.85 11.89 4 456987 4626 63027405
Cytomegalovirus colitis 20.80 11.89 50 456941 2322 63029709
Leukopenia 20.77 11.89 715 456276 76575 62955456
Tooth extraction 20.73 11.89 26 456965 10238 63021793
Blood chloride decreased 20.71 11.89 7 456984 5535 63026496
Large intestine polyp 20.65 11.89 17 456974 8140 63023891
Abortion induced 20.63 11.89 26 456965 10216 63021815
Enterovirus myocarditis 20.61 11.89 6 456985 4 63032027
Skin disorder 20.61 11.89 126 456865 29381 63002650
Activated partial thromboplastin time prolonged 20.58 11.89 12 456979 6881 63025150
Peptic ulcer 20.58 11.89 4 456987 4583 63027448
Lower gastrointestinal haemorrhage 20.53 11.89 16 456975 7874 63024157
BK virus infection 20.53 11.89 61 456930 3218 63028813
Psychomotor hyperactivity 20.52 11.89 28 456963 10635 63021396
Pruritus allergic 20.40 11.89 39 456952 1543 63030488
Tension headache 20.36 11.89 6 456985 5180 63026851
Hypernatraemia 20.35 11.89 15 456976 7594 63024437
Device use error 20.31 11.89 8 456983 5753 63026278
Lymphoedema 20.27 11.89 33 456958 11659 63020372
Pemphigoid 20.26 11.89 14 456977 7330 63024701
Feeding disorder 20.22 11.89 41 456950 13321 63018710
Extrasystoles 20.21 11.89 6 456985 5154 63026877
Device adhesion issue 20.09 11.89 6 456985 5135 63026896
Larynx irritation 20.08 11.89 12 456979 112 63031919
Post cholecystectomy syndrome 20.06 11.89 20 456971 419 63031612
SARS-CoV-2 antibody test negative 20.00 11.89 14 456977 175 63031856
Gastrointestinal motility disorder 19.96 11.89 6 456985 5113 63026918
Renal transplant failure 19.94 11.89 26 456965 736 63031295
Feeling drunk 19.93 11.89 3 456988 4139 63027892
Drug level above therapeutic 19.92 11.89 5 456986 4800 63027231
Lupus nephritis 19.89 11.89 55 456936 2784 63029247
Vitreous floaters 19.88 11.89 9 456982 5957 63026074
Erythropoiesis abnormal 19.80 11.89 17 456974 292 63031739
Affect lability 19.78 11.89 31 456960 11120 63020911
Blood pressure increased 19.69 11.89 1387 455604 160675 62871356
Colitis 19.62 11.89 239 456752 48289 62983742
Cholecystectomy 19.59 11.89 29 456962 10648 63021383
Restless legs syndrome 19.58 11.89 68 456923 18463 63013568
Pharyngitis streptococcal 19.57 11.89 29 456962 10643 63021388
Dyspnoea at rest 19.52 11.89 3 456988 4076 63027955
Coxsackie viral infection 19.49 11.89 8 456983 29 63032002
Natural killer-cell leukaemia 19.41 11.89 11 456980 92 63031939
Affective disorder 19.37 11.89 10 456981 6136 63025895
Gastrointestinal sounds abnormal 19.34 11.89 3 456988 4048 63027983
C-reactive protein 19.34 11.89 78 456913 4804 63027227
Productive cough 19.33 11.89 329 456662 62879 62969152
Amyotrophic lateral sclerosis 19.28 11.89 32 456959 1131 63030900
Erythema multiforme 19.27 11.89 27 456964 10142 63021889
Myasthenia gravis crisis 19.23 11.89 21 456970 491 63031540
Partial seizures 19.18 11.89 9 456982 5833 63026198
Ovarian hyperstimulation syndrome 19.10 11.89 3 456988 4011 63028020
Cyst 19.09 11.89 46 456945 14053 63017978
Bacteraemia 19.09 11.89 200 456791 17148 63014883
Drug-induced liver injury 19.08 11.89 191 456800 40031 62992000
Hypoaesthesia 19.03 11.89 1004 455987 167389 62864642
Gene mutation 19.00 11.89 39 456952 1626 63030405
Ammonia increased 19.00 11.89 5 456986 4651 63027380
Metabolic encephalopathy 18.99 11.89 9 456982 5800 63026231
Joint effusion 18.92 11.89 197 456794 16863 63015168
Haemorrhagic stroke 18.89 11.89 9 456982 5783 63026248
Facial bones fracture 18.89 11.89 3 456988 3979 63028052
Vaginal discharge 18.89 11.89 23 456968 9175 63022856
Encephalitis 18.88 11.89 119 456872 8761 63023270
Psychiatric symptom 18.83 11.89 7 456984 5216 63026815
Brain natriuretic peptide increased 18.77 11.89 7 456984 5206 63026825
Apnoea 18.76 11.89 18 456973 8004 63024027
Blood pressure abnormal 18.73 11.89 52 456939 15146 63016885
Lymphopenia 18.64 11.89 208 456783 18119 63013912
Catheter site erythema 18.62 11.89 4 456987 4272 63027759
Stupor 18.61 11.89 4 456987 4271 63027760
Campylobacter gastroenteritis 18.61 11.89 20 456971 459 63031572
Myelitis 18.60 11.89 35 456956 1368 63030663
Sudden death 18.58 11.89 29 456962 10420 63021611
Gastrointestinal toxicity 18.54 11.89 107 456884 7634 63024397
Electrocardiogram ST segment elevation 18.54 11.89 3 456988 3924 63028107
Multiple system atrophy 18.44 11.89 14 456977 200 63031831
Carpal tunnel syndrome 18.41 11.89 82 456909 20735 63011296
Frustration tolerance decreased 18.40 11.89 14 456977 6974 63025057
Malnutrition 18.36 11.89 53 456938 15245 63016786
Post-acute COVID-19 syndrome 18.35 11.89 19 456972 417 63031614
Aspartate aminotransferase 18.32 11.89 19 456972 418 63031613
Rheumatoid factor 18.31 11.89 17 456974 325 63031706
Enterovirus infection 18.31 11.89 29 456962 985 63031046
Bone density abnormal 18.30 11.89 60 456931 3338 63028693
Oxygen consumption increased 18.26 11.89 3 456988 3881 63028150
Failure to thrive 18.22 11.89 15 456976 7183 63024848
Splenic marginal zone lymphoma recurrent 18.21 11.89 6 456985 9 63032022
Ocular lymphoma 18.21 11.89 9 456982 55 63031976
Gout 18.21 11.89 43 456948 13228 63018803
Bone pain 18.18 11.89 280 456711 54361 62977670
Status epilepticus 18.12 11.89 53 456938 15180 63016851
Overlap syndrome 18.11 11.89 27 456964 869 63031162
Photopsia 18.10 11.89 5 456986 4504 63027527
Shock haemorrhagic 18.04 11.89 27 456964 9868 63022163
Gallbladder disorder 18.04 11.89 72 456919 18770 63013261
Pancreatic carcinoma 17.98 11.89 17 456974 7611 63024420
Ligament sprain 17.94 11.89 41 456950 12759 63019272
Tachypnoea 17.94 11.89 64 456927 17238 63014793
Emphysema 17.92 11.89 32 456959 10906 63021125
Cerebral atrophy 17.91 11.89 7 456984 5059 63026972
Neuromyelitis optica spectrum disorder 17.89 11.89 29 456962 1005 63031026
Galactorrhoea 17.86 11.89 4 456987 4151 63027880
Scar 17.85 11.89 46 456945 13736 63018295
Gastroenteritis viral 17.73 11.89 99 456892 23601 63008430
T-lymphocyte count increased 17.68 11.89 11 456980 111 63031920
Cardiac pacemaker insertion 17.68 11.89 4 456987 4122 63027909
Enterococcal bacteraemia 17.64 11.89 35 456956 1424 63030607
Subclavian artery occlusion 17.57 11.89 7 456984 23 63032008
Human herpesvirus 6 infection 17.56 11.89 54 456937 2903 63029128
Soft tissue sarcoma 17.55 11.89 12 456979 144 63031887
Gingival swelling 17.55 11.89 5 456986 4413 63027618
Hepatotoxicity 17.55 11.89 369 456622 36672 62995359
Paranoia 17.54 11.89 36 456955 11643 63020388
Body temperature increased 17.48 11.89 177 456814 37015 62995016
Respiratory distress 17.48 11.89 158 456833 33793 62998238
Carotid artery occlusion 17.42 11.89 6 456985 4688 63027343
Overweight 17.41 11.89 3 456988 3748 63028283
Blindness transient 17.36 11.89 3 456988 3741 63028290
Muscle disorder 17.35 11.89 7 456984 4962 63027069
Hypophosphataemia 17.34 11.89 35 456956 11391 63020640
B-cell aplasia 17.32 11.89 10 456981 87 63031944
Ventricular septal defect 17.31 11.89 5 456986 4373 63027658
Stillbirth 17.17 11.89 14 456977 6736 63025295
Acute myeloid leukaemia 17.16 11.89 194 456797 16953 63015078
Metabolic disorder 17.16 11.89 13 456978 6490 63025541
Diarrhoea haemorrhagic 17.14 11.89 24 456967 9018 63023013
Hypertonia 17.08 11.89 6 456985 4631 63027400
Transaminases increased 17.02 11.89 144 456847 31223 63000808
Wound secretion 16.95 11.89 6 456985 4608 63027423
Procedural complication 16.92 11.89 9 456982 5430 63026601
Neutropenic sepsis 16.92 11.89 187 456804 16251 63015780
Atrial septal defect 16.90 11.89 15 456976 6923 63025108
Internal haemorrhage 16.89 11.89 8 456983 5157 63026874
Genitourinary tract infection 16.87 11.89 14 456977 229 63031802
Injury associated with device 16.87 11.89 3 456988 3663 63028368
Injury 16.86 11.89 666 456325 72581 62959450
Ejection fraction decreased 16.86 11.89 93 456898 22239 63009792
Ecchymosis 16.83 11.89 34 456957 11060 63020971
Haemodynamic instability 16.83 11.89 25 456966 9165 63022866
Cestode infection 16.80 11.89 15 456976 272 63031759
Serum ferritin increased 16.77 11.89 12 456979 6170 63025861
Foot fracture 16.76 11.89 102 456889 23812 63008219
Thyroid function test abnormal 16.74 11.89 3 456988 3644 63028387
Viral infection 16.65 11.89 170 456821 35493 62996538
Multiple sclerosis 16.54 11.89 105 456886 24267 63007764
Blood immunoglobulin A increased 16.53 11.89 24 456967 754 63031277
Ovarian cyst 16.52 11.89 59 456932 15886 63016145
Tooth loss 16.49 11.89 15 456976 6841 63025190
Maternal exposure during breast feeding 16.48 11.89 5 456986 4236 63027795
Atrioventricular block second degree 16.37 11.89 4 456987 3910 63028121
Musculoskeletal discomfort 16.36 11.89 70 456921 17897 63014134
Precancerous cells present 16.32 11.89 34 456957 1433 63030598
Toxic encephalopathy 16.30 11.89 14 456977 6565 63025466
Proteinuria 16.28 11.89 210 456781 18935 63013096
CD8 lymphocytes increased 16.24 11.89 6 456985 15 63032016
Polydipsia 16.22 11.89 3 456988 3561 63028470
Refractory anaemia with an excess of blasts 16.21 11.89 18 456973 429 63031602
Spinal pain 16.15 11.89 45 456946 13094 63018937
Catatonia 16.14 11.89 6 456985 4471 63027560
Product dispensing error 16.13 11.89 31 456960 10274 63021757
Dry eye 16.01 11.89 202 456789 40559 62991472
Cytomegalovirus test positive 16.00 11.89 53 456938 2965 63029066
Marginal zone lymphoma recurrent 15.97 11.89 6 456985 16 63032015
Bundle branch block right 15.95 11.89 8 456983 4990 63027041
Cytomegalovirus chorioretinitis 15.94 11.89 38 456953 1755 63030276
Toxic skin eruption 15.94 11.89 44 456947 12841 63019190
Hepatic encephalopathy 15.92 11.89 36 456955 11246 63020785
Cardiomyopathy acute 15.91 11.89 14 456977 249 63031782
Fear of injection 15.86 11.89 97 456894 7067 63024964
Crystal nephropathy 15.85 11.89 26 456965 910 63031121
Retinal deposits 15.81 11.89 9 456982 76 63031955
Vulvovaginal ulceration 15.77 11.89 4 456987 0 63032031
Acute flaccid myelitis 15.77 11.89 4 456987 0 63032031
Blood immunoglobulin M increased 15.76 11.89 29 456962 1114 63030917
Diastolic dysfunction 15.75 11.89 14 456977 6457 63025574
Nystagmus 15.70 11.89 13 456978 6207 63025824
Electrocardiogram T wave inversion 15.69 11.89 3 456988 3478 63028553
Epstein-Barr virus associated lymphoproliferative disorder 15.63 11.89 39 456952 1855 63030176
Pneumonia cytomegaloviral 15.62 11.89 43 456948 2171 63029860
Traumatic lung injury 15.58 11.89 35 456956 1554 63030477
Adenovirus reactivation 15.55 11.89 11 456980 140 63031891
Faeces soft 15.51 11.89 11 456980 5681 63026350
Device loosening 15.50 11.89 18 456973 451 63031580
Pelvic fracture 15.48 11.89 47 456944 13301 63018730
Pain in jaw 15.47 11.89 220 456771 43276 62988755
Clonus 15.44 11.89 7 456984 4629 63027402
Foetal growth restriction 15.39 11.89 19 456972 7534 63024497
Small for dates baby 15.36 11.89 4 456987 3747 63028284
Anosmia 15.35 11.89 16 456975 6844 63025187
Urine odour abnormal 15.34 11.89 14 456977 6375 63025656
Leukaemic lymphoma 15.33 11.89 9 456982 81 63031950
Coronary artery occlusion 15.27 11.89 22 456969 8169 63023862
Localised oedema 15.18 11.89 10 456981 5368 63026663
Blood lactate dehydrogenase abnormal 15.17 11.89 16 456975 359 63031672
CD4 lymphocytes increased 15.10 11.89 11 456980 147 63031884
B-lymphocyte count abnormal 15.07 11.89 8 456983 58 63031973
Oesophageal pain 15.06 11.89 4 456987 3697 63028334
Product administration interrupted 15.05 11.89 8 456983 4828 63027203
Blood creatine increased 15.03 11.89 11 456980 5590 63026441
Jaw disorder 15.02 11.89 10 456981 5339 63026692
Urine abnormality 15.01 11.89 17 456974 7002 63025029
Normal newborn 14.97 11.89 23 456968 8318 63023713
Eye discharge 14.90 11.89 13 456978 6050 63025981
Movement disorder 14.87 11.89 93 456898 21568 63010463
White blood cell count decreased 14.85 11.89 834 456157 138270 62893761
Skin laceration 14.82 11.89 99 456892 22609 63009422
Mucous stools 14.81 11.89 6 456985 4242 63027789
Fistula 14.80 11.89 33 456958 10360 63021671
Bacterial test positive 14.80 11.89 10 456981 5297 63026734
Atrial tachycardia 14.76 11.89 6 456985 4234 63027797
Tumour flare 14.72 11.89 16 456975 372 63031659
Ocular discomfort 14.72 11.89 6 456985 4227 63027804
Injection site discolouration 14.71 11.89 21 456970 7827 63024204
Infected seroma 14.71 11.89 9 456982 88 63031943
Hypertriglyceridaemia 14.69 11.89 14 456977 6245 63025786
Hepatic cytolysis 14.67 11.89 59 456932 15348 63016683
Intervertebral disc protrusion 14.66 11.89 105 456886 23604 63008427
Laryngeal pain 14.66 11.89 7 456984 4491 63027540
Selective IgG subclass deficiency 14.62 11.89 5 456986 9 63032022
Osteopenia 14.61 11.89 83 456908 19702 63012329
Erythema 14.60 11.89 1078 455913 174673 62857358
Pharyngeal disorder 14.60 11.89 39 456952 1934 63030097
Germ cell cancer 14.52 11.89 8 456983 63 63031968
Postoperative wound infection 14.51 11.89 36 456955 10889 63021142
Graft versus host disease in skin 14.50 11.89 50 456941 2855 63029176
Herpes oesophagitis 14.47 11.89 12 456979 196 63031835
Splenic abscess 14.44 11.89 11 456980 158 63031873
Blood phosphorus decreased 14.40 11.89 7 456984 4446 63027585
Myositis 14.40 11.89 28 456963 9238 63022793
Mood swings 14.32 11.89 75 456916 18173 63013858
Sacroiliitis 14.28 11.89 3 456988 3254 63028777
Vitamin D decreased 14.20 11.89 33 456958 10209 63021822
Blood urine present 14.16 11.89 58 456933 15011 63017020
Primary immunodeficiency syndrome 14.14 11.89 7 456984 43 63031988
Peripheral venous disease 14.11 11.89 172 456819 15305 63016726
Uterine leiomyoma 14.11 11.89 28 456963 9170 63022861
Sinusitis 14.08 11.89 1850 455141 224803 62807228
Oligohydramnios 14.07 11.89 15 456976 6351 63025680
Lung diffusion test decreased 14.06 11.89 21 456970 677 63031354
Alanine aminotransferase abnormal 14.06 11.89 67 456924 4437 63027594
Ventricular arrhythmia 14.02 11.89 5 456986 3823 63028208
Allergic oedema 14.02 11.89 23 456968 805 63031226
Gastric stenosis 14.01 11.89 8 456983 68 63031963
Chronic lymphocytic leukaemia refractory 14.00 11.89 7 456984 44 63031987
Ketoacidosis 13.98 11.89 7 456984 4371 63027660
Glomerular filtration rate increased 13.95 11.89 24 456967 874 63031157
Faecal calprotectin increased 13.94 11.89 3 456988 3200 63028831
Mucocutaneous ulceration 13.93 11.89 11 456980 167 63031864
Ganglioneuroma 13.83 11.89 10 456981 132 63031899
Swollen joint count 13.80 11.89 28 456963 1158 63030873
Muscle haemorrhage 13.79 11.89 3 456988 3176 63028855
Catheter site haemorrhage 13.76 11.89 3 456988 3172 63028859
Vulvovaginal candidiasis 13.76 11.89 3 456988 3172 63028859
Nervous system disorder 13.71 11.89 79 456912 18687 63013344
Haemarthrosis 13.68 11.89 3 456988 3158 63028873
Tongue oedema 13.67 11.89 8 456983 4578 63027453
Neoplasm malignant 13.67 11.89 296 456695 29565 63002466
Blood glucose fluctuation 13.62 11.89 8 456983 4568 63027463
5q minus syndrome 13.61 11.89 12 456979 214 63031817
Delirium 13.60 11.89 269 456722 50272 62981759
Wheezing 13.60 11.89 556 456435 95039 62936992
Infusion site pruritus 13.59 11.89 14 456977 6021 63026010
Diffuse alveolar damage 13.55 11.89 24 456967 895 63031136
Heart rate irregular 13.53 11.89 100 456891 22321 63009710
Laboratory test abnormal 13.53 11.89 126 456865 26786 63005245
Breast cancer 13.48 11.89 256 456735 48127 62983904
Obstruction 13.46 11.89 3 456988 3124 63028907
Quadrantanopia 13.44 11.89 6 456985 28 63032003
Low birth weight baby 13.44 11.89 19 456972 7110 63024921
Cardiovascular disorder 13.40 11.89 42 456949 11770 63020261
Passenger lymphocyte syndrome 13.35 11.89 8 456983 75 63031956
Osteoporosis 13.35 11.89 522 456469 56816 62975215
Back disorder 13.35 11.89 38 456953 10979 63021052
Functional gastrointestinal disorder 13.32 11.89 7 456984 4252 63027779
Rheumatoid lung 13.31 11.89 59 456932 3789 63028242
Combined immunodeficiency 13.30 11.89 9 456982 106 63031925
Central nervous system enteroviral infection 13.27 11.89 6 456985 29 63032002
Nasal discomfort 13.23 11.89 9 456982 4751 63027280
Follicular lymphoma 13.20 11.89 12 456979 223 63031808
Nail pigmentation 13.20 11.89 11 456980 181 63031850
Haematuria 13.20 11.89 140 456851 29017 63003014
Diabetic neuropathy 13.18 11.89 6 456985 3958 63028073
Viral upper respiratory tract infection 13.15 11.89 98 456893 7626 63024405
Rash pustular 13.15 11.89 20 456971 7262 63024769
Intervertebral disc annular tear 13.13 11.89 5 456986 14 63032017
Occult blood positive 13.09 11.89 5 456986 3665 63028366
Polycystic ovaries 13.05 11.89 8 456983 4463 63027568
Oral infection 13.02 11.89 10 456981 4958 63027073
Ocular icterus 13.01 11.89 5 456986 3651 63028380
Mucocutaneous leishmaniasis 13.01 11.89 15 456976 373 63031658
Chronic sinusitis 12.99 11.89 48 456943 12795 63019236
Adverse drug reaction 12.98 11.89 700 456291 79014 62953017
Tooth fracture 12.97 11.89 39 456952 11071 63020960
Respiratory syncytial virus infection 12.94 11.89 19 456972 6999 63025032
Blood parathyroid hormone increased 12.91 11.89 3 456988 3035 63028996
Toothache 12.88 11.89 83 456908 19116 63012915
Unintentional medical device removal 12.87 11.89 15 456976 6100 63025931
Strongyloidiasis 12.82 11.89 28 456963 1220 63030811
Nail operation 12.81 11.89 23 456968 867 63031164
Body height decreased 12.78 11.89 34 456957 10044 63021987
Glycosylated haemoglobin increased 12.76 11.89 46 456945 12352 63019679
Trigger finger 12.71 11.89 8 456983 4400 63027631
Vulval ulceration 12.70 11.89 14 456977 331 63031700
Hypoalbuminaemia 12.69 11.89 43 456948 11762 63020269
Pneumothorax 12.67 11.89 67 456924 16194 63015837
Hand fracture 12.66 11.89 13 456978 5600 63026431
Organising pneumonia 12.65 11.89 78 456913 5698 63026333
Hepatitis B surface antigen positive 12.61 11.89 7 456984 56 63031975
Social avoidant behaviour 12.60 11.89 3 456988 2985 63029046
Renal vein thrombosis 12.58 11.89 15 456976 387 63031644
Complement factor C3 decreased 12.57 11.89 13 456978 285 63031746
Cholesteatoma 12.55 11.89 10 456981 154 63031877
Diabetes mellitus inadequate control 12.54 11.89 61 456930 15065 63016966
Pustular psoriasis 12.52 11.89 9 456982 4617 63027414
Spinal osteoarthritis 12.44 11.89 67 456924 16119 63015912
Appetite disorder 12.38 11.89 21 456970 7300 63024731
Intervertebral disc disorder 12.37 11.89 10 456981 4833 63027198
Atrial flutter 12.37 11.89 33 456958 9739 63022292
Laryngitis 12.34 11.89 181 456810 16786 63015245
CD8 lymphocytes decreased 12.34 11.89 10 456981 158 63031873
Hepatitis B core antibody positive 12.30 11.89 11 456980 200 63031831
Limb mass 12.30 11.89 51 456940 3181 63028850
Malabsorption 12.29 11.89 7 456984 4065 63027966
Abscess 12.26 11.89 70 456921 16598 63015433
Aortic arteriosclerosis 12.26 11.89 16 456975 6193 63025838
Cell-mediated immune deficiency 12.23 11.89 6 456985 36 63031995
Plasma cells decreased 12.23 11.89 6 456985 36 63031995
Petit mal epilepsy 12.22 11.89 6 456985 3788 63028243
Food poisoning 12.21 11.89 8 456983 4308 63027723
Herpes zoster infection neurological 12.21 11.89 12 456979 247 63031784
Neutropenic infection 12.19 11.89 29 456962 1338 63030693
Injection site hypersensitivity 12.18 11.89 38 456953 2059 63029972
Granuloma 12.12 11.89 77 456914 5684 63026347
Uterine haemorrhage 12.12 11.89 7 456984 4034 63027997
Arthritis reactive 12.11 11.89 15 456976 403 63031628
Pneumonia viral 12.09 11.89 98 456893 7824 63024207
Immune effector cell-associated neurotoxicity syndrome 12.08 11.89 40 456951 2237 63029794
Septic shock 12.05 11.89 591 456400 66038 62965993
Neuroendocrine carcinoma of the skin 12.01 11.89 18 456973 582 63031449
Stent placement 12.00 11.89 6 456985 3749 63028282
Intracranial aneurysm 11.91 11.89 6 456985 3733 63028298
Cushingoid 11.91 11.89 103 456888 8382 63023649

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 2381.48 11.80 5936 168757 413588 34368650
Febrile neutropenia 1436.65 11.80 2502 172191 134347 34647891
Disease progression 1098.00 11.80 1949 172744 106128 34676110
Progressive multifocal leukoencephalopathy 972.88 11.80 607 174086 9157 34773081
Neutropenia 904.81 11.80 2242 172451 154536 34627702
Intentional product use issue 756.60 11.80 1191 173502 58625 34723613
Hypogammaglobulinaemia 725.55 11.80 463 174230 7277 34774961
Diffuse large B-cell lymphoma recurrent 703.67 11.80 337 174356 2891 34779347
Hepatitis B 691.21 11.80 409 174284 5574 34776664
Infusion related reaction 674.46 11.80 1059 173634 51998 34730240
Drug ineffective 656.23 11.80 4203 170490 452548 34329690
Hepatitis B reactivation 632.63 11.80 333 174360 3558 34778680
Product use in unapproved indication 594.00 11.80 1600 173093 115899 34666339
COVID-19 491.14 11.80 1151 173542 76399 34705839
Lymphoma 489.44 11.80 444 174249 12063 34770175
Pneumocystis jirovecii pneumonia 460.94 11.80 530 174163 19180 34763058
Cytomegalovirus infection 452.21 11.80 604 174089 25531 34756707
Drug interaction 445.60 11.80 291 174402 225655 34556583
Tumour lysis syndrome 438.70 11.80 482 174211 16577 34765661
Completed suicide 427.44 11.80 14 174679 98154 34684084
Myelodysplastic syndrome 372.98 11.80 470 174223 18738 34763500
Toxicity to various agents 344.76 11.80 297 174396 200065 34582173
Synovitis 340.30 11.80 385 174308 13681 34768557
Cytopenia 336.71 11.80 365 174328 12358 34769880
Apparent death 334.08 11.80 215 174478 3429 34778809
Product dose omission issue 332.86 11.80 93 174600 119618 34662620
COVID-19 pneumonia 310.26 11.80 403 174290 16564 34765674
Overdose 301.83 11.80 47 174646 91012 34691226
Therapy partial responder 294.01 11.80 298 174395 9318 34772920
Myelosuppression 292.31 11.80 418 174275 18847 34763391
Contraindicated product administered 281.34 11.80 435 174258 21046 34761192
Rhabdomyolysis 279.10 11.80 15 174678 68148 34714090
Bone marrow failure 278.84 11.80 514 174179 28739 34753499
Drug effective for unapproved indication 274.95 11.80 168 174525 2434 34779804
Fall 271.10 11.80 371 174322 202514 34579724
Chills 264.09 11.80 948 173745 80095 34702143
Diffuse large B-cell lymphoma refractory 263.30 11.80 128 174565 1138 34781100
Treatment failure 253.83 11.80 654 174039 46043 34736195
Neutrophil count decreased 252.73 11.80 691 174002 50413 34731825
B-cell lymphoma recurrent 241.68 11.80 105 174588 699 34781539
Infection 239.38 11.80 994 173699 89921 34692317
Agranulocytosis 239.00 11.80 428 174265 23393 34758845
Disease recurrence 231.00 11.80 398 174295 21092 34761146
Pancytopenia 227.91 11.80 1011 173682 94146 34688092
Lymphadenopathy 223.61 11.80 461 174232 28002 34754236
Blood pressure diastolic abnormal 212.31 11.80 183 174510 4635 34777603
Pyrexia 212.09 11.80 2567 172126 330446 34451792
Drug intolerance 211.45 11.80 717 173976 58853 34723385
Lymphopenia 211.38 11.80 329 174364 16006 34766232
Cytokine release syndrome 208.05 11.80 394 174299 22483 34759755
Intentional overdose 198.39 11.80 4 174689 43670 34738568
Dizziness 197.78 11.80 506 174187 218015 34564223
Cytomegalovirus infection reactivation 192.98 11.80 178 174515 4940 34777298
Post transplant lymphoproliferative disorder 184.57 11.80 194 174499 6334 34775904
Mantle cell lymphoma recurrent 182.69 11.80 85 174608 678 34781560
Haematotoxicity 182.58 11.80 215 174478 7979 34774259
Somnolence 182.13 11.80 172 174521 110944 34671294
Diffuse large B-cell lymphoma 177 11.80 201 174492 7169 34775069
Bronchopulmonary aspergillosis 176.93 11.80 286 174407 14373 34767865
Hospitalisation 176.22 11.80 35 174658 56867 34725371
Sepsis 173.99 11.80 1424 173269 165137 34617101
Neutropenic sepsis 173.57 11.80 274 174419 13493 34768745
Chronic lymphocytic leukaemia recurrent 168.72 11.80 67 174626 343 34781895
Epstein-Barr virus infection 166.40 11.80 198 174495 7430 34774808
Joint swelling 160.02 11.80 658 174035 59232 34723006
Anxiety 159.33 11.80 157 174536 99271 34682967
Blood pressure systolic abnormal 156.07 11.80 141 174552 3807 34778431
B-lymphocyte count decreased 155.10 11.80 72 174621 571 34781667
Drug ineffective for unapproved indication 154.24 11.80 356 174337 23359 34758879
Confusional state 152.90 11.80 306 174387 143854 34638384
Hypoglycaemia 152.59 11.80 42 174651 54598 34727640
Muscle spasms 152.41 11.80 93 174600 74908 34707330
Fatigue 151.74 11.80 1158 173535 369495 34412743
Second primary malignancy 151.51 11.80 192 174501 7694 34774544
Ill-defined disorder 146.06 11.80 255 174438 13654 34768584
Vomiting 145.28 11.80 690 174003 246931 34535307
Hallucination 143.03 11.80 40 174653 51458 34730780
International normalised ratio increased 140.62 11.80 32 174661 47295 34734943
White blood cell count decreased 136.41 11.80 880 173813 94565 34687673
Electrocardiogram QT prolonged 135.94 11.80 21 174672 40931 34741307
Aspergillus infection 135.68 11.80 230 174463 12024 34770214
Acquired gene mutation 134.31 11.80 84 174609 1271 34780967
Suicide attempt 132.28 11.80 19 174674 39097 34743141
Herpes zoster 130.87 11.80 424 174269 33975 34748263
Pneumocystis jirovecii infection 129.98 11.80 91 174602 1679 34780559
Plasma cell myeloma 125.74 11.80 28 174665 42009 34740229
Intentional product misuse 125.60 11.80 36 174657 45575 34736663
Diverticulitis 125.39 11.80 296 174397 19708 34762530
Suicidal ideation 124.71 11.80 25 174668 40363 34741875
Febrile bone marrow aplasia 124.32 11.80 178 174515 8031 34774207
Blood pressure systolic increased 121.09 11.80 318 174375 22634 34759604
Agitation 118.25 11.80 70 174623 57329 34724909
Leukopenia 117.33 11.80 622 174071 62234 34720004
Septic shock 116.90 11.80 685 174008 71149 34711089
Aggression 116.45 11.80 26 174667 38938 34743300
Blood creatine phosphokinase increased 115.32 11.80 40 174653 44817 34737421
Cerebrovascular accident 114.13 11.80 154 174539 84657 34697581
Diarrhoea 114.04 11.80 1324 173369 388588 34393650
Blood lactate dehydrogenase increased 113.70 11.80 311 174382 22679 34759559
Seizure 112.47 11.80 221 174472 104636 34677602
Thrombocytopenia 112.18 11.80 1234 173459 155013 34627225
Pneumonia cytomegaloviral 110.86 11.80 104 174589 2950 34779288
Mucosal inflammation 110.04 11.80 433 174260 38189 34744049
Red blood cell sedimentation rate increased 109.53 11.80 178 174515 8984 34773254
Gait disturbance 109.19 11.80 160 174533 84980 34697258
Coma 107.09 11.80 47 174646 45631 34736607
Blood pressure fluctuation 106.89 11.80 323 174370 24926 34757312
Cytomegalovirus chorioretinitis 105.66 11.80 109 174584 3480 34778758
Hyponatraemia 105.46 11.80 156 174537 82535 34699703
Oxygen saturation decreased 104.17 11.80 538 174155 53280 34728958
Inappropriate schedule of product administration 103.69 11.80 95 174598 62201 34720037
Bradycardia 103.46 11.80 135 174558 75283 34706955
Loss of consciousness 102.49 11.80 159 174534 82508 34699730
Decreased appetite 101.98 11.80 456 174237 165936 34616302
Cardio-respiratory arrest 100.98 11.80 77 174616 55196 34727042
Platelet count decreased 99.86 11.80 975 173718 118742 34663496
Stress 99.72 11.80 16 174677 30331 34751907
Hepatitis E 99.64 11.80 83 174610 2003 34780235
JC virus infection 99.59 11.80 85 174608 2123 34780115
Arthropathy 99.05 11.80 328 174365 26579 34755659
Acute myeloid leukaemia 97.26 11.80 254 174439 18016 34764222
Serum sickness 96.41 11.80 80 174613 1920 34780318
Chondropathy 95.81 11.80 60 174633 910 34781328
Neoplasm progression 95.77 11.80 295 174398 23005 34759233
Syncope 95.28 11.80 196 174497 91255 34690983
Humoral immune defect 95.10 11.80 36 174657 158 34782080
C-reactive protein increased 93.97 11.80 525 174168 53573 34728665
Memory impairment 93.28 11.80 50 174643 43268 34738970
Depression 91.42 11.80 220 174473 96878 34685360
Coronary artery disease 91.20 11.80 65 174628 48240 34733998
Constipation 90.94 11.80 364 174329 136618 34645620
Lymphoma transformation 89.26 11.80 38 174655 239 34781999
Metabolic acidosis 88.94 11.80 54 174639 43626 34738612
Injection site pain 88.52 11.80 42 174651 38963 34743275
Atlantoaxial instability 87.50 11.80 40 174653 305 34781933
Pulmonary thrombosis 87.31 11.80 143 174550 7264 34774974
Wrong technique in product usage process 85.99 11.80 36 174657 35950 34746288
Spinal instability 85.34 11.80 40 174653 325 34781913
Dehydration 85.24 11.80 347 174346 129622 34652616
Mineral metabolism disorder 84.62 11.80 40 174653 332 34781906
Pneumonia 84.33 11.80 2389 172304 360238 34422000
Accidental overdose 83.77 11.80 4 174689 20136 34762102
Myalgia 82.84 11.80 186 174507 83924 34698314
Coombs positive haemolytic anaemia 80.92 11.80 54 174639 918 34781320
C-reactive protein abnormal 80.39 11.80 151 174542 8559 34773679
Myocardial infarction 79.57 11.80 323 174370 120762 34661476
Treatment noncompliance 79.56 11.80 21 174672 28079 34754159
Onychoclasis 79.35 11.80 70 174623 1830 34780408
Drug withdrawal syndrome 79.21 11.80 5 174688 19829 34762409
Acute kidney injury 79.08 11.80 1062 173631 303926 34478312
Dislocation of vertebra 78.50 11.80 40 174653 397 34781841
Autoimmune haemolytic anaemia 77.85 11.80 104 174589 4392 34777846
Herpes simplex 77.60 11.80 116 174577 5443 34776795
Insomnia 76.86 11.80 264 174429 103643 34678595
Cardiac failure congestive 76.54 11.80 191 174502 83079 34699159
Dyskinesia 75.51 11.80 11 174682 22402 34759836
Squamous cell carcinoma 75.41 11.80 173 174520 11302 34770936
End stage renal disease 74.90 11.80 148 174545 8713 34773525
Psoriasis 74.89 11.80 51 174642 38761 34743477
Irritability 74.74 11.80 16 174677 24674 34757564
Medication error 74.52 11.80 18 174675 25547 34756691
No adverse event 74.38 11.80 268 174425 22659 34759579
Therapy non-responder 74.12 11.80 389 174304 38757 34743481
Adenovirus infection 73.81 11.80 110 174583 5147 34777091
Lymphadenitis 73.50 11.80 69 174624 1959 34780279
Sarcoidosis 73.17 11.80 81 174612 2807 34779431
Pseudomonas infection 73.06 11.80 179 174514 12203 34770035
Adenoviral hepatitis 72.98 11.80 41 174652 503 34781735
Post-acute COVID-19 syndrome 72.94 11.80 29 174664 149 34782089
Diabetic ketoacidosis 70.68 11.80 5 174688 18027 34764211
Cardiac arrest 70.66 11.80 245 174448 95914 34686324
Therapeutic product effect decreased 70.49 11.80 352 174341 34391 34747847
Hallucination, visual 69.54 11.80 5 174688 17786 34764452
Oedema peripheral 68.83 11.80 336 174357 119476 34662762
B-cell lymphoma refractory 68.72 11.80 28 174665 155 34782083
Vaccination failure 68.45 11.80 52 174641 1094 34781144
Abdominal distension 68.27 11.80 117 174576 58375 34723863
Nausea 67.43 11.80 1245 173448 338663 34443575
Basal cell carcinoma 67.39 11.80 234 174459 19424 34762814
Acne cystic 66.95 11.80 38 174655 476 34781762
Central nervous system lymphoma 66.65 11.80 49 174644 979 34781259
Pneumonia adenoviral 66.25 11.80 34 174659 343 34781895
Malaise 66.00 11.80 602 174091 185223 34597015
Chronic lymphocytic leukaemia 65.90 11.80 93 174600 4139 34778099
Chest pain 65.80 11.80 368 174325 126394 34655844
Posterior reversible encephalopathy syndrome 65.34 11.80 150 174543 9804 34772434
Pulmonary embolism 65.30 11.80 711 173982 89035 34693203
Terminal state 65.07 11.80 89 174604 3845 34778393
Hyperkalaemia 64.67 11.80 158 174535 69231 34713007
Dry skin 64.64 11.80 38 174655 31249 34750989
Haemolysis 64.60 11.80 132 174561 7962 34774276
Angioedema 64.58 11.80 55 174638 37319 34744919
Knee arthroplasty 63.72 11.80 125 174568 7319 34774919
Abdominal pain 63.47 11.80 518 174175 163100 34619138
Babesiosis 63.27 11.80 25 174668 126 34782112
Encephalitis cytomegalovirus 62.99 11.80 39 174654 579 34781659
Intestinal sepsis 62.52 11.80 40 174653 631 34781607
Respiratory arrest 62.41 11.80 31 174662 28012 34754226
Disorientation 62.20 11.80 45 174648 33143 34749095
Labelled drug-drug interaction medication error 62.03 11.80 3 174690 14936 34767302
Gastrointestinal haemorrhage 60.66 11.80 232 174461 88245 34693993
Incorrect dose administered 60.33 11.80 68 174625 40447 34741791
Immunosuppression 60.32 11.80 111 174582 6193 34776045
Drug resistance 60.09 11.80 273 174420 25654 34756584
Unevaluable event 60.02 11.80 45 174648 32545 34749693
Lymphocytosis 59.71 11.80 69 174624 2508 34779730
Arthritis bacterial 59.40 11.80 98 174595 5008 34777230
Hand deformity 58.21 11.80 82 174611 3643 34778595
Interstitial lung disease 57.99 11.80 539 174154 64743 34717495
Dysgeusia 57.90 11.80 30 174663 26467 34755771
Dyspnoea 57.85 11.80 1438 173255 375344 34406894
Injury 57.55 11.80 16 174677 20671 34761567
Erectile dysfunction 57.34 11.80 16 174677 20621 34761617
Throat irritation 57.20 11.80 148 174545 10437 34771801
Intentional self-injury 56.43 11.80 3 174690 13768 34768470
Nightmare 56.37 11.80 4 174689 14387 34767851
Adverse drug reaction 56.02 11.80 39 174654 29303 34752935
Depressed level of consciousness 55.39 11.80 80 174613 42761 34739477
Foot deformity 55.39 11.80 89 174604 4448 34777790
Ureaplasma infection 55.37 11.80 30 174663 341 34781897
Melaena 55.32 11.80 57 174636 35323 34746915
Lethargy 54.95 11.80 75 174618 41047 34741191
Candida infection 54.87 11.80 204 174489 17511 34764727
Restlessness 52.57 11.80 31 174662 25451 34756787
B-cell lymphoma 52.46 11.80 85 174608 4278 34777960
Pneumonitis 52.46 11.80 319 174374 33559 34748679
Joint arthroplasty 52.27 11.80 40 174653 851 34781387
Encephalitis enteroviral 52.13 11.80 22 174671 135 34782103
Microsporidia infection 51.15 11.80 36 174657 670 34781568
Vision blurred 50.87 11.80 95 174598 45868 34736370
Withdrawal syndrome 50.16 11.80 3 174690 12452 34769786
Asthma 50.06 11.80 85 174608 42571 34739667
Product prescribing error 50.04 11.80 26 174667 22901 34759337
Depressed mood 50.03 11.80 17 174676 19300 34762938
Polyneuropathy 49.92 11.80 176 174517 14720 34767518
Cytomegalovirus test positive 49.88 11.80 78 174615 3808 34778430
Ventricular tachycardia 49.85 11.80 36 174657 26543 34755695
Osteosclerosis 49.82 11.80 46 174647 1278 34780960
Deep vein thrombosis 49.34 11.80 521 174172 64727 34717511
Lactic acidosis 48.95 11.80 61 174632 34711 34747527
BK virus infection 48.69 11.80 96 174597 5642 34776596
Sopor 48.64 11.80 3 174690 12133 34770105
Delirium 48.62 11.80 91 174602 43900 34738338
Heart rate decreased 48.57 11.80 298 174395 31447 34750791
Sleep disorder 48.48 11.80 52 174641 31636 34750602
Intervertebral disc space narrowing 48.37 11.80 41 174652 1014 34781224
Unresponsive to stimuli 48.33 11.80 40 174653 27529 34754709
Venoocclusive liver disease 47.89 11.80 116 174577 7850 34774388
Cytology abnormal 47.84 11.80 28 174665 373 34781865
Prostatic specific antigen increased 47.65 11.80 8 174685 14672 34767566
Follicular lymphoma 47.33 11.80 21 174672 148 34782090
Hepatic failure 47.19 11.80 315 174378 34216 34748022
JC polyomavirus test positive 46.95 11.80 34 174659 663 34781575
Liver function test abnormal 46.43 11.80 52 174641 31022 34751216
Haematemesis 46.40 11.80 42 174651 27669 34754569
Epstein-Barr viraemia 46.32 11.80 44 174649 1268 34780970
Tooth loss 46.17 11.80 75 174618 3783 34778455
Amnesia 46.00 11.80 39 174654 26524 34755714
Cytomegalovirus viraemia 45.53 11.80 109 174584 7321 34774917
Drug dependence 45.16 11.80 33 174660 24184 34758054
Orthostatic hypotension 44.95 11.80 38 174655 25881 34756357
Pain in extremity 44.80 11.80 410 174283 126103 34656135
Rheumatoid factor positive 44.44 11.80 33 174660 670 34781568
Hypoaesthesia 44.14 11.80 158 174535 61286 34720952
Abnormal behaviour 44.05 11.80 36 174657 24933 34757305
Asthenia 44.05 11.80 913 173780 244338 34537900
Mantle cell lymphoma refractory 43.96 11.80 17 174676 80 34782158
Herpes simplex encephalitis 43.92 11.80 25 174668 315 34781923
Therapy cessation 43.85 11.80 15 174678 16958 34765280
Platelet count abnormal 43.71 11.80 63 174630 2859 34779379
Pulmonary fibrosis 43.59 11.80 195 174498 18201 34764037
Psychotic disorder 43.46 11.80 35 174658 24417 34757821
Synovial cyst 43.34 11.80 56 174637 2288 34779950
Pancreatitis acute 43.25 11.80 46 174647 28095 34754143
Bacteraemia 43.02 11.80 204 174489 19513 34762725
Blood urea increased 43.02 11.80 53 174640 30311 34751927
Hyperpyrexia 43.01 11.80 61 174632 2727 34779511
Temperature intolerance 42.97 11.80 68 174625 3354 34778884
Bone marrow infiltration 42.60 11.80 21 174672 193 34782045
Bladder transitional cell carcinoma 42.31 11.80 59 174634 2596 34779642
Pneumonia fungal 42.26 11.80 103 174590 6997 34775241
Lymphocyte count decreased 42.26 11.80 224 174469 22398 34759840
Paraesthesia 41.60 11.80 172 174521 64000 34718238
Cardiogenic shock 41.48 11.80 43 174650 26575 34755663
Gamma-glutamyltransferase increased 41.44 11.80 51 174642 29180 34753058
Frequent bowel movements 41.43 11.80 7 174686 12780 34769458
Blood glucose increased 41.30 11.80 182 174511 66536 34715702
Cerebral aspergillosis 41.27 11.80 43 174650 1389 34780849
Enterococcal infection 41.22 11.80 121 174572 9185 34773053
Drug tolerance decreased 41.16 11.80 50 174643 1917 34780321
Mantle cell lymphoma 40.98 11.80 42 174651 1330 34780908
Glomerulonephritis 40.94 11.80 50 174643 1928 34780310
Atypical pneumonia 40.85 11.80 66 174627 3314 34778924
Viral haemorrhagic cystitis 40.58 11.80 39 174654 1141 34781097
Respiratory failure 40.53 11.80 765 173928 107807 34674431
Sweat gland tumour 40.48 11.80 26 174667 413 34781825
Disturbance in attention 40.34 11.80 42 174651 25903 34756335
5q minus syndrome 40.31 11.80 18 174675 129 34782109
Haematochezia 40.24 11.80 110 174583 46424 34735814
Mental status changes 40.16 11.80 81 174612 38002 34744236
Haemophagocytic lymphohistiocytosis 39.84 11.80 149 174544 12824 34769414
Dystonia 39.78 11.80 4 174689 10841 34771397
Encephalitis viral 39.69 11.80 39 174654 1173 34781065
Ventricular fibrillation 39.38 11.80 34 174659 22920 34759318
Dry mouth 39.32 11.80 56 174637 30109 34752129
Emotional distress 39.30 11.80 13 174680 15013 34767225
Pseudomonal bacteraemia 39.08 11.80 42 174651 1407 34780831
Blood pressure diastolic increased 38.98 11.80 81 174612 4944 34777294
Immune effector cell-associated neurotoxicity syndrome 38.88 11.80 68 174625 3645 34778593
Cerebral haemorrhage 38.85 11.80 72 174621 34865 34747373
Blood immunoglobulin G decreased 38.51 11.80 42 174651 1431 34780807
Abdominal pain upper 38.46 11.80 205 174488 71285 34710953
Pancreatitis 38.27 11.80 86 174607 38805 34743433
Muscle rigidity 38.27 11.80 4 174689 10514 34771724
Injection site swelling 38.04 11.80 6 174687 11521 34770717
Immune thrombocytopenia 37.71 11.80 116 174577 9036 34773202
Paraneoplastic pemphigus 37.62 11.80 14 174679 58 34782180
Chronic lymphocytic leukaemia refractory 37.58 11.80 15 174678 78 34782160
Pneumonia escherichia 37.46 11.80 25 174668 425 34781813
Neoplasm recurrence 37.38 11.80 51 174642 2198 34780040
Polyarthritis 37.37 11.80 75 174618 4465 34777773
Cardiotoxicity 36.94 11.80 85 174608 5563 34776675
Immunodeficiency common variable 36.74 11.80 18 174675 163 34782075
Blood immunoglobulin A decreased 36.66 11.80 21 174672 268 34781970
Secondary immunodeficiency 36.58 11.80 24 174669 396 34781842
SARS-CoV-2 antibody test negative 36.49 11.80 12 174681 31 34782207
Tumour flare 36.45 11.80 32 174661 831 34781407
Graft versus host disease 36.38 11.80 126 174567 10443 34771795
Miosis 36.36 11.80 3 174690 9532 34772706
Therapeutic response decreased 36.27 11.80 261 174432 29052 34753186
Product quality issue 36.17 11.80 20 174673 17015 34765223
Gastritis bacterial 36.00 11.80 19 174674 204 34782034
Hypokalaemia 35.91 11.80 159 174534 58055 34724183
Underdose 35.91 11.80 12 174681 13768 34768470
Blood alkaline phosphatase increased 35.78 11.80 63 174630 31112 34751126
Adenovirus reactivation 35.76 11.80 19 174674 207 34782031
Immunoglobulins decreased 35.56 11.80 30 174663 737 34781501
Hypomagnesaemia 35.54 11.80 34 174659 21817 34760421
Incorrect route of product administration 35.22 11.80 15 174678 14830 34767408
Epstein-Barr virus infection reactivation 35.18 11.80 35 174658 1069 34781169
Chronic allograft nephropathy 34.90 11.80 37 174656 1220 34781018
Disability 34.87 11.80 75 174618 4690 34777548
Injection site haemorrhage 34.81 11.80 4 174689 9764 34772474
Acute myocardial infarction 34.81 11.80 144 174549 53575 34728663
Meningitis cryptococcal 34.75 11.80 51 174642 2353 34779885
Injection site erythema 34.74 11.80 18 174675 15881 34766357
Extravasation 34.70 11.80 45 174648 1845 34780393
Human herpesvirus 6 infection 34.30 11.80 47 174646 2034 34780204
Anti-cyclic citrullinated peptide antibody positive 34.02 11.80 44 174649 1799 34780439
Lung infiltration 33.80 11.80 141 174552 12764 34769474
Hypotension 33.60 11.80 847 173846 220802 34561436
Sleep disorder due to general medical condition, insomnia type 33.49 11.80 37 174656 1279 34780959
Neoplasm 33.28 11.80 80 174613 5387 34776851
Post procedural complication 33.22 11.80 8 174685 11380 34770858
Visual impairment 32.97 11.80 82 174611 35720 34746518
Cardiomegaly 32.96 11.80 18 174675 15420 34766818
Aspartate aminotransferase increased 32.89 11.80 201 174492 67582 34714656
Blood immunoglobulin M increased 32.73 11.80 19 174674 249 34781989
Blood potassium decreased 32.65 11.80 25 174668 17890 34764348
Dysarthria 32.55 11.80 79 174614 34703 34747535
Osteoarthritis 32.35 11.80 195 174498 20447 34761791
Injection site bruising 32.29 11.80 3 174690 8660 34773578
Therapy interrupted 32.24 11.80 14 174679 13683 34768555
Chronic lymphocytic leukaemia transformation 32.02 11.80 17 174676 185 34782053
Gastrosplenic fistula 31.82 11.80 12 174681 52 34782186
Respiratory depression 31.80 11.80 21 174672 16224 34766014
Hip fracture 31.75 11.80 10 174683 11915 34770323
Tooth fracture 31.69 11.80 62 174631 3623 34778615
Scleroderma 31.35 11.80 39 174654 1533 34780705
Osteonecrosis of jaw 31.30 11.80 26 174667 17863 34764375
Prerenal failure 31.27 11.80 45 174648 2039 34780199
Delusion 31.22 11.80 12 174681 12623 34769615
Neutropenic infection 31.22 11.80 38 174655 1460 34780778
Hairy cell leukaemia recurrent 31.21 11.80 8 174685 4 34782234
Intestinal perforation 31.18 11.80 108 174585 8952 34773286
Device malfunction 31.04 11.80 7 174686 10414 34771824
Exposure during pregnancy 31.00 11.80 4 174689 8930 34773308
Hyperlipidaemia 30.93 11.80 17 174676 14512 34767726
Neurological decompensation 30.64 11.80 54 174639 2912 34779326
Appendicitis 30.56 11.80 18 174675 14789 34767449
Klebsiella infection 30.50 11.80 103 174590 8428 34773810
Myoclonus 30.25 11.80 18 174675 14707 34767531
Strongyloidiasis 30.16 11.80 51 174642 2660 34779578
Pharyngeal paraesthesia 30.14 11.80 26 174667 659 34781579
Transient ischaemic attack 29.74 11.80 58 174635 27555 34754683
CD4 lymphocytes decreased 29.72 11.80 40 174653 1701 34780537
Salivary hypersecretion 29.68 11.80 4 174689 8640 34773598
Psychomotor hyperactivity 29.60 11.80 6 174687 9616 34772622
Neuroborreliosis 29.57 11.80 10 174683 29 34782209
Congenital cardiovascular anomaly 29.37 11.80 16 174677 184 34782054
Granuloma skin 29.22 11.80 34 174659 1245 34780993
Swelling face 29.03 11.80 44 174649 23061 34759177
Hypersomnia 28.70 11.80 13 174680 12394 34769844
Hyperglycaemia 28.70 11.80 101 174592 39379 34742859
Head injury 28.68 11.80 29 174664 18131 34764107
Prothrombin time prolonged 28.66 11.80 6 174687 9400 34772838
Back pain 28.64 11.80 432 174261 121357 34660881
Blood pressure increased 28.60 11.80 608 174085 87494 34694744
Lip swelling 28.59 11.80 23 174670 16057 34766181
Cerebral infarction 28.43 11.80 59 174634 27396 34754842
Cystitis viral 28.43 11.80 23 174670 532 34781706
Myocardial ischaemia 28.41 11.80 27 174666 17381 34764857
Neck pain 28.39 11.80 52 174641 25297 34756941
Hallucination, auditory 28.34 11.80 12 174681 11905 34770333
Urinary retention 28.32 11.80 90 174603 36198 34746040
Mucormycosis 28.00 11.80 79 174614 5863 34776375
Electrocardiogram abnormal 27.97 11.80 6 174687 9241 34772997
Rectal haemorrhage 27.91 11.80 105 174588 40144 34742094
Thrombotic microangiopathy 27.73 11.80 116 174577 10514 34771724
Rib fracture 27.67 11.80 19 174674 14381 34767857
Gait inability 27.59 11.80 38 174655 20720 34761518
Cystitis escherichia 27.57 11.80 15 174678 172 34782066
Disseminated cytomegaloviral infection 27.54 11.80 16 174677 210 34782028
Altered state of consciousness 27.43 11.80 45 174648 22848 34759390
Musculoskeletal stiffness 27.38 11.80 355 174338 46325 34735913
Foetal exposure during pregnancy 27.34 11.80 98 174595 38003 34744235
Pseudomonal sepsis 27.31 11.80 57 174636 3490 34778748
Escherichia infection 27.26 11.80 97 174596 8148 34774090
Wrist deformity 27.16 11.80 19 174674 350 34781888
Splenomegaly 27.09 11.80 148 174545 14969 34767269
Ear pruritus 26.89 11.80 19 174674 356 34781882
Faeces discoloured 26.81 11.80 21 174672 14857 34767381
Chromaturia 26.80 11.80 20 174673 14500 34767738
Acute hepatic failure 26.72 11.80 140 174553 13934 34768304
Anger 26.65 11.80 13 174680 11871 34770367
Colitis ulcerative 26.53 11.80 26 174667 16494 34765744
Obstructive airways disorder 26.52 11.80 23 174670 15471 34766767
Atrial septal defect 26.41 11.80 3 174690 7389 34774849
Autoimmune lymphoproliferative syndrome 26.39 11.80 14 174679 152 34782086
Device issue 26.39 11.80 8 174685 9769 34772469
Infective exacerbation of chronic obstructive airways disease 26.37 11.80 39 174654 1812 34780426
Mood swings 26.33 11.80 4 174689 7897 34774341
Palmar-plantar erythrodysaesthesia syndrome 26.32 11.80 27 174666 16768 34765470
Hypocalcaemia 26.17 11.80 51 174642 24238 34758000
Burning sensation 26.17 11.80 32 174661 18362 34763876
Cytomegalovirus gastritis 26.11 11.80 16 174677 233 34782005
Flatulence 26.03 11.80 41 174652 21157 34761081
Product administration error 25.92 11.80 26 174667 16318 34765920
Blood pressure diastolic decreased 25.92 11.80 102 174591 8992 34773246
Tachycardia 25.72 11.80 285 174408 84487 34697751
Pneumonia viral 25.61 11.80 52 174641 3122 34779116
Wheezing 25.58 11.80 113 174580 41289 34740949
Enterovirus infection 25.58 11.80 28 174665 958 34781280
Upper gastrointestinal haemorrhage 25.45 11.80 56 174637 25462 34756776
Cytomegalovirus enterocolitis 25.39 11.80 28 174665 966 34781272
Periostitis 25.37 11.80 17 174676 291 34781947
Human rhinovirus test positive 25.36 11.80 15 174678 204 34782034
Cystitis haemorrhagic 25.31 11.80 74 174619 5605 34776633
Abdominal lymphadenopathy 25.25 11.80 26 174667 828 34781410
B-lymphocyte count increased 25.25 11.80 9 174684 32 34782206
Marginal zone lymphoma recurrent 25.25 11.80 9 174684 32 34782206
Lymphoplasmacytoid lymphoma/immunocytoma 25.25 11.80 9 174684 32 34782206
Device related thrombosis 25.22 11.80 30 174663 1125 34781113
Iron deficiency anaemia 25.21 11.80 10 174683 10319 34771919
Rhinovirus infection 25.20 11.80 62 174631 4237 34778001
Headache 25.19 11.80 787 173906 199848 34582390
Ageusia 25.13 11.80 10 174683 10298 34771940
Nervousness 25.08 11.80 16 174677 12590 34769648
Poisoning 25.04 11.80 15 174678 12211 34770027
Haemoglobin abnormal 24.94 11.80 58 174635 3822 34778416
Prescribed overdose 24.87 11.80 11 174682 10636 34771602
B-cell aplasia 24.75 11.80 12 174681 106 34782132
Blood glucose decreased 24.73 11.80 18 174675 13219 34769019
Escherichia sepsis 24.62 11.80 65 174628 4639 34777599
Swollen tongue 24.61 11.80 22 174671 14583 34767655
Skin discolouration 24.39 11.80 32 174661 17813 34764425
Eczema 24.25 11.80 34 174659 18402 34763836
Meningitis tuberculous 24.24 11.80 23 174670 662 34781576
Pneumonia klebsiella 24.21 11.80 52 174641 3248 34778990
Panniculitis 24.18 11.80 39 174654 1955 34780283
Cerebral toxoplasmosis 24.14 11.80 36 174657 1685 34780553
Epistaxis 24.13 11.80 181 174512 58070 34724168
Cardiac disorder 24.12 11.80 122 174571 43004 34739234
Neuropathy peripheral 24.00 11.80 565 174128 82698 34699540
Organising pneumonia 23.91 11.80 75 174618 5904 34776334
Dyspnoea exertional 23.89 11.80 123 174570 43156 34739082
Febrile infection 23.81 11.80 41 174652 2170 34780068
Diaphragm muscle weakness 23.75 11.80 13 174680 151 34782087
Cryoglobulinaemia 23.61 11.80 19 174674 436 34781802
Mania 23.56 11.80 9 174684 9502 34772736
Gene mutation 23.51 11.80 32 174661 1376 34780862
Chronic graft versus host disease 23.48 11.80 61 174632 4312 34777926
Obesity 23.43 11.80 18 174675 12860 34769378
Central nervous system fungal infection 23.41 11.80 17 174676 333 34781905
Mydriasis 23.36 11.80 4 174689 7233 34775005
Pruritus 23.29 11.80 536 174157 141445 34640793
Neuroendocrine carcinoma of the skin 23.24 11.80 24 174669 767 34781471
Acute lung injury 23.24 11.80 33 174660 1477 34780761
Nocardiosis 23.18 11.80 57 174636 3894 34778344
Accidental exposure to product 23.16 11.80 18 174675 12784 34769454
Road traffic accident 23.13 11.80 32 174661 17418 34764820
Limb deformity 23.12 11.80 21 174672 571 34781667
Polyomavirus viraemia 23.07 11.80 26 174667 919 34781319
Oedema 23.05 11.80 134 174559 45607 34736631
Disorder of orbit 23.00 11.80 11 174682 94 34782144
Fungal infection 22.76 11.80 147 174546 15788 34766450
Balance disorder 22.74 11.80 115 174578 40539 34741699
Hepatitis B surface antigen positive 22.73 11.80 12 174681 129 34782109
Adverse event 22.72 11.80 37 174656 18840 34763398
Human polyomavirus infection 22.63 11.80 23 174670 721 34781517
Microscopic polyangiitis 22.60 11.80 14 174679 208 34782030
Vasculitis 22.58 11.80 114 174579 11182 34771056
Drug level increased 22.44 11.80 48 174645 22048 34760190
Human herpesvirus 8 infection 22.41 11.80 26 174667 949 34781289
Graft versus host disease in skin 22.37 11.80 56 174637 3869 34778369
Blood sodium decreased 22.36 11.80 29 174664 16222 34766016
Generalised tonic-clonic seizure 22.35 11.80 45 174648 21129 34761109
Joint ankylosis 22.22 11.80 33 174660 1539 34780699
Fluid retention 22.18 11.80 65 174628 26822 34755416
Peripheral swelling 22.17 11.80 260 174433 76281 34705957
Hospice care 22.05 11.80 4 174689 6936 34775302
Muscle twitching 22.00 11.80 12 174681 10286 34771952
Feeling abnormal 21.90 11.80 206 174487 63029 34719209
Multiple sclerosis relapse 21.87 11.80 20 174673 13113 34769125
Glycosylated haemoglobin increased 21.81 11.80 15 174678 11345 34770893
Cellulitis gangrenous 21.78 11.80 13 174680 180 34782058
Eating disorder 21.78 11.80 7 174686 8233 34774005
Small intestinal perforation 21.75 11.80 39 174654 2132 34780106
Pulmonary congestion 21.72 11.80 22 174671 13743 34768495
Antineutrophil cytoplasmic antibody positive 21.63 11.80 23 174670 761 34781477
Traumatic lung injury 21.59 11.80 29 174664 1231 34781007
B-lymphocyte abnormalities 21.59 11.80 7 174686 17 34782221
Fluoride increased 21.36 11.80 9 174684 55 34782183
Erysipelas 21.32 11.80 63 174630 4800 34777438
Product dispensing error 21.32 11.80 3 174690 6271 34775967
Speech disorder 21.26 11.80 62 174631 25624 34756614
Metastases to meninges 21.24 11.80 31 174662 1423 34780815
Candida pneumonia 21.17 11.80 18 174675 447 34781791
Chronic kidney disease 21.15 11.80 120 174573 41090 34741148
Rheumatoid nodule 21.12 11.80 46 174647 2901 34779337
Pneumonia aspiration 20.98 11.80 123 174570 41780 34740458
Ecthyma 20.94 11.80 18 174675 454 34781784
Surgery 20.81 11.80 24 174669 14133 34768105
Systemic mycosis 20.79 11.80 32 174661 1541 34780697
Refractory anaemia with an excess of blasts 20.77 11.80 17 174676 400 34781838
West Nile viral infection 20.76 11.80 22 174671 725 34781513
Nervous system disorder 20.67 11.80 134 174559 14409 34767829
Mental impairment 20.67 11.80 13 174680 10309 34771929
Injection site mass 20.66 11.80 4 174689 6622 34775616
Alanine aminotransferase increased 20.62 11.80 282 174411 80533 34701705
Epstein-Barr virus associated lymphoproliferative disorder 20.60 11.80 36 174657 1928 34780310
Transplant rejection 20.57 11.80 104 174589 10207 34772031
Antineutrophil cytoplasmic antibody increased 20.53 11.80 7 174686 21 34782217
Device leakage 20.44 11.80 4 174689 6571 34775667
Thirst 20.35 11.80 7 174686 7888 34774350
Medical device implantation 20.23 11.80 20 174673 606 34781632
Bacterial sepsis 20.21 11.80 65 174628 5185 34777053
Injection site pruritus 20.18 11.80 5 174688 6978 34775260
Drug level decreased 20.15 11.80 7 174686 7839 34774399
Gynaecomastia 20.14 11.80 13 174680 10167 34772071
Campylobacter infection 20.07 11.80 24 174669 905 34781333
Sudden death 20.03 11.80 28 174665 15173 34767065
Tricuspid valve incompetence 19.95 11.80 12 174681 9748 34772490
Chylothorax 19.95 11.80 22 174671 759 34781479
Hypophagia 19.87 11.80 58 174635 23964 34758274
Red blood cell sedimentation rate 19.83 11.80 27 174666 1161 34781077
Pneumonia bacterial 19.79 11.80 114 174579 11758 34770480
Pollakiuria 19.77 11.80 43 174650 19631 34762607
Blood cholesterol increased 19.74 11.80 46 174647 20497 34761741
Haemolytic anaemia 19.73 11.80 104 174589 10375 34771863
Parkinsonism 19.66 11.80 8 174685 8130 34774108
Mass 19.64 11.80 85 174608 7820 34774418
Acquired C1 inhibitor deficiency 19.63 11.80 6 174687 11 34782227
Inappropriate antidiuretic hormone secretion 19.42 11.80 21 174672 12732 34769506
Skin exfoliation 19.39 11.80 71 174622 27361 34754877
Noninfectious myelitis 19.29 11.80 6 174687 12 34782226
Acute hepatitis B 19.28 11.80 12 174681 180 34782058
Gastric stenosis 19.21 11.80 9 174684 73 34782165
Meningoencephalitis viral 19.16 11.80 11 174682 141 34782097
Epstein-Barr virus associated lymphoma 19.15 11.80 20 174673 648 34781590
Lung adenocarcinoma 19.05 11.80 59 174634 4612 34777626
Metastases to spleen 19.03 11.80 17 174676 452 34781786
Activated partial thromboplastin time prolonged 18.77 11.80 10 174683 8685 34773553
Drug reaction with eosinophilia and systemic symptoms 18.68 11.80 93 174600 32919 34749319
Palpitations 18.65 11.80 120 174573 39866 34742372
Needle issue 18.65 11.80 4 174689 6161 34776077
Contusion 18.60 11.80 106 174587 36258 34745980
Nasal cavity cancer 18.55 11.80 12 174681 193 34782045
Blood stem cell transplant failure 18.53 11.80 16 174677 406 34781832
Neutrophil Pelger-Huet anomaly present 18.47 11.80 13 174680 242 34781996
Cardiac murmur 18.46 11.80 8 174685 7829 34774409
Intestinal atresia 18.42 11.80 9 174684 81 34782157
Herpes oesophagitis 18.39 11.80 11 174682 153 34782085
Pulmonary toxicity 18.38 11.80 70 174623 6077 34776161
Bacterial infection 18.34 11.80 147 174546 16916 34765322
Cytomegalovirus colitis 18.32 11.80 42 174651 2742 34779496
Blood loss anaemia 18.32 11.80 9 174684 8185 34774053
Mood altered 18.31 11.80 11 174682 8941 34773297
Neurofibrosarcoma 18.26 11.80 7 174686 32 34782206
Haematuria 18.24 11.80 161 174532 49905 34732333
Micturition urgency 18.23 11.80 5 174688 6520 34775718
Intestinal obstruction 18.23 11.80 56 174637 22766 34759472
T-lymphocyte count decreased 18.13 11.80 12 174681 201 34782037
Hepatitis fulminant 18.10 11.80 54 174639 4136 34778102
Alanine aminotransferase abnormal 18.01 11.80 58 174635 4630 34777608
Varicella 17.93 11.80 31 174662 1646 34780592
Haemoptysis 17.93 11.80 102 174591 34904 34747334
Cytomegalovirus oesophagitis 17.92 11.80 17 174676 489 34781749
Bone marrow reticulin fibrosis 17.90 11.80 11 174682 161 34782077
Coronary artery occlusion 17.89 11.80 17 174676 10945 34771293
Full blood count decreased 17.79 11.80 40 174653 18048 34764190
Hip arthroplasty 17.74 11.80 56 174637 4423 34777815
Enterococcal bacteraemia 17.64 11.80 33 174660 1864 34780374
Glomerulonephritis rapidly progressive 17.62 11.80 19 174674 639 34781599
Chronic graft versus host disease in skin 17.59 11.80 23 174670 951 34781287
Dialysis 17.58 11.80 18 174675 11190 34771048
Urinary incontinence 17.55 11.80 43 174650 18831 34763407
Mycobacterium chelonae infection 17.52 11.80 21 174672 794 34781444
Viraemia 17.52 11.80 26 174667 1212 34781026
Haemorrhage 17.51 11.80 168 174525 51202 34731036
Hepatic amoebiasis 17.39 11.80 8 174685 62 34782176
Ureteric compression 17.38 11.80 13 174680 267 34781971
Pulmonary sarcoidosis 17.36 11.80 18 174675 578 34781660
Encephalitis Japanese B 17.36 11.80 6 174687 19 34782219
Presyncope 17.27 11.80 44 174649 19015 34763223
Infusion site discolouration 17.23 11.80 10 174683 131 34782107
Postural tremor 17.19 11.80 14 174679 327 34781911
Squamous cell carcinoma of skin 17.18 11.80 103 174590 10778 34771460
Central nervous system infection 17.10 11.80 19 174674 661 34781577
Metastases to bone marrow 17.04 11.80 17 174676 521 34781717
Hypercalcaemia 17.03 11.80 134 174559 15334 34766904
Osteolysis 16.99 11.80 44 174649 3104 34779134
Leukoencephalopathy 16.97 11.80 53 174640 4162 34778076
Granulocytopenia neonatal 16.90 11.80 6 174687 21 34782217
Rebound effect 16.89 11.80 45 174648 3229 34779009
Disease susceptibility 16.86 11.80 8 174685 67 34782171
Bladder cancer 16.84 11.80 35 174658 16243 34765995
Shock 16.81 11.80 63 174630 24116 34758122
Prostatic abscess 16.79 11.80 16 174677 463 34781775
Adenoviral haemorrhagic cystitis 16.79 11.80 15 174678 399 34781839
Proteus infection 16.77 11.80 24 174669 1082 34781156
Bone erosion 16.64 11.80 51 174642 3964 34778274
Left ventricular hypertrophy 16.61 11.80 10 174683 8120 34774118
Central nervous system enteroviral infection 16.58 11.80 7 174686 43 34782195
Hyperthyroidism 16.54 11.80 17 174676 10549 34771689
Helicobacter sepsis 16.49 11.80 6 174687 23 34782215
Arteriosclerosis coronary artery 16.44 11.80 23 174670 12462 34769776
Hepatic infection fungal 16.43 11.80 11 174682 188 34782050
Mitral valve incompetence 16.43 11.80 31 174662 14912 34767326
Leukaemia cutis 16.28 11.80 8 174685 73 34782165
Drug level below therapeutic 16.27 11.80 4 174689 5611 34776627
Viral sepsis 16.26 11.80 9 174684 107 34782131
Ocular hyperaemia 16.21 11.80 20 174673 11432 34770806
Hepatitis D 16.19 11.80 7 174686 46 34782192
Urethral obstruction 16.19 11.80 11 174682 193 34782045
Jejunal perforation 16.18 11.80 12 174681 243 34781995
Heparin-induced thrombocytopenia 16.18 11.80 4 174689 5591 34776647
Rheumatoid factor 16.18 11.80 8 174685 74 34782164
Morphoea 16.09 11.80 11 174682 195 34782043
Cardiomyopathy 16.04 11.80 141 174552 16667 34765571
Stomatitis 15.99 11.80 300 174393 42214 34740024
Blood triglycerides increased 15.90 11.80 29 174664 14130 34768108
Eye irritation 15.88 11.80 9 174684 7552 34774686
Isosporiasis 15.84 11.80 9 174684 113 34782125
Accident 15.84 11.80 3 174690 5044 34777194
Pulmonary mass 15.80 11.80 114 174579 12698 34769540
Cushingoid 15.76 11.80 39 174654 2675 34779563
Mononeuropathy multiplex 15.76 11.80 11 174682 202 34782036
Atrioventricular block complete 15.75 11.80 14 174679 9305 34772933
Superinfection bacterial 15.71 11.80 21 174672 887 34781351
Blood bilirubin decreased 15.65 11.80 14 174679 373 34781865
Eye pain 15.63 11.80 27 174666 13435 34768803
Central nervous system neoplasm 15.56 11.80 8 174685 81 34782157
Pulmonary oedema 15.54 11.80 157 174536 47372 34734866
Dysstasia 15.54 11.80 23 174670 12172 34770066
Pneumonia pseudomonal 15.50 11.80 49 174644 3873 34778365
Discomfort 15.46 11.80 46 174647 18892 34763346
Cholelithiasis 15.43 11.80 54 174639 21094 34761144
Cryptococcosis 15.38 11.80 36 174657 2383 34779855
Human herpesvirus 6 infection reactivation 15.35 11.80 10 174683 163 34782075
Superior mesenteric artery syndrome 15.31 11.80 8 174685 84 34782154
Phlebitis infective 15.31 11.80 9 174684 121 34782117
Recurrent cancer 15.31 11.80 26 174667 1361 34780877
Rhinorrhoea 15.29 11.80 71 174622 25597 34756641
Resorption bone increased 15.26 11.80 11 174682 213 34782025
Oral pain 15.23 11.80 19 174674 10808 34771430
Granulomatosis with polyangiitis 15.21 11.80 24 174669 1181 34781057
Polyomavirus-associated nephropathy 15.17 11.80 48 174645 3796 34778442
Electrocardiogram QRS complex prolonged 15.16 11.80 3 174690 4891 34777347
Retroperitoneal lymphadenopathy 15.16 11.80 20 174673 834 34781404
Rheumatoid arthritis 15.14 11.80 272 174421 37966 34744272
Immunodeficiency 15.13 11.80 61 174632 5437 34776801
Dermatitis atopic 15.13 11.80 4 174689 5343 34776895
Transformation to acute myeloid leukaemia 15.11 11.80 19 174674 755 34781483
Hemianopia 15.11 11.80 18 174675 676 34781562
Bone cyst 15.09 11.80 28 174665 1572 34780666
Blood potassium increased 15.01 11.80 38 174655 16457 34765781
CD4 lymphocyte percentage decreased 14.99 11.80 4 174689 3 34782235
Interchange of vaccine products 14.99 11.80 4 174689 3 34782235
Drug hypersensitivity 14.99 11.80 517 174176 80012 34702226
Device occlusion 14.92 11.80 7 174686 6538 34775700
Haemorrhagic stroke 14.89 11.80 7 174686 6532 34775706
Metastases to bone 14.84 11.80 23 174670 11947 34770291
Blood HIV RNA increased 14.84 11.80 24 174669 1206 34781032
Primary amyloidosis 14.81 11.80 9 174684 129 34782109
Adenocarcinoma gastric 14.80 11.80 24 174669 1209 34781029
Pleural effusion 14.79 11.80 522 174171 81024 34701214
Blood immunoglobulin M decreased 14.79 11.80 15 174678 469 34781769
Cat scratch disease 14.79 11.80 10 174683 174 34782064
Cytokine storm 14.78 11.80 18 174675 692 34781546
Viral cardiomyopathy 14.76 11.80 6 174687 33 34782205
Peripheral coldness 14.70 11.80 9 174684 7242 34774996
Vocal cord paralysis 14.70 11.80 21 174672 945 34781293
Tooth disorder 14.70 11.80 99 174594 10783 34771455
Schizophrenia 14.67 11.80 13 174680 8653 34773585
Gallbladder adenocarcinoma 14.66 11.80 5 174688 15 34782223
Electrocardiogram ST segment elevation 14.66 11.80 4 174689 5234 34777004
Hepatitis C RNA increased 14.64 11.80 12 174681 283 34781955
Brain natriuretic peptide increased 14.62 11.80 5 174688 5654 34776584
Acute respiratory distress syndrome 14.60 11.80 196 174497 25773 34756465
Sleep disorder due to a general medical condition 14.59 11.80 4 174689 5217 34777021
Acidosis 14.58 11.80 20 174673 10925 34771313
Monocyte count increased 14.53 11.80 54 174639 4633 34777605
Dysuria 14.51 11.80 78 174615 27074 34755164
Dermatitis exfoliative generalised 14.37 11.80 46 174647 3661 34778577
Aplasia 14.34 11.80 53 174640 4535 34777703
Infective thrombosis 14.32 11.80 7 174686 63 34782175
Lymphoproliferative disorder 14.31 11.80 38 174655 2721 34779517
Empyema 14.26 11.80 42 174651 3194 34779044
Haemodialysis 14.26 11.80 19 174674 10507 34771731
Chronic obstructive pulmonary disease 14.23 11.80 166 174527 48752 34733486
Engraftment syndrome 14.19 11.80 21 174672 976 34781262
Rash 14.15 11.80 941 173752 221811 34560427
Musculoskeletal disorder 14.13 11.80 65 174628 6139 34776099
Blood parathyroid hormone decreased 14.08 11.80 26 174667 1454 34780784
SARS-CoV-2 viraemia 14.06 11.80 6 174687 38 34782200
Increased appetite 14.01 11.80 10 174683 7419 34774819
Soft tissue disorder 13.99 11.80 18 174675 732 34781506
Pneumonia respiratory syncytial viral 13.95 11.80 20 174673 903 34781335
Lymphocytic lymphoma 13.93 11.80 6 174687 39 34782199
Neuromyotonia 13.93 11.80 6 174687 39 34782199
Abscess 13.92 11.80 104 174589 11713 34770525
Ventricular hypertrophy 13.91 11.80 3 174690 4604 34777634
Mucocutaneous haemorrhage 13.91 11.80 8 174685 103 34782135
Positron emission tomogram abnormal 13.90 11.80 9 174684 145 34782093
Respiratory acidosis 13.87 11.80 4 174689 5046 34777192
Infection reactivation 13.86 11.80 26 174667 1472 34780766
Panic attack 13.85 11.80 16 174677 9416 34772822
Back disorder 13.85 11.80 8 174685 6643 34775595
Urticaria 13.84 11.80 409 174284 61968 34720270
Metastatic lymphoma 13.81 11.80 10 174683 195 34782043
Cutaneous T-cell lymphoma recurrent 13.80 11.80 6 174687 40 34782198
Schizoaffective disorder depressive type 13.77 11.80 5 174688 19 34782219
Glottis carcinoma 13.77 11.80 5 174688 19 34782219
Necrotic lymphadenopathy 13.77 11.80 5 174688 19 34782219
Catatonia 13.77 11.80 4 174689 5021 34777217
Carotid artery stenosis 13.74 11.80 4 174689 5015 34777223
Choking 13.72 11.80 4 174689 5011 34777227
Chromosomal deletion 13.68 11.80 6 174687 41 34782197
Crystal nephropathy 13.67 11.80 14 174679 443 34781795
Device related infection 13.66 11.80 139 174554 17098 34765140
Bone disorder 13.63 11.80 7 174686 6208 34776030
Hepatitis C 13.62 11.80 90 174603 9740 34772498
Herpes virus infection 13.60 11.80 38 174655 2804 34779434
Follicle centre lymphoma, follicular grade I, II, III recurrent 13.58 11.80 4 174689 6 34782232
Atypical fibroxanthoma 13.55 11.80 10 174683 201 34782037
Sensitivity to weather change 13.55 11.80 27 174666 1599 34780639
Splenic candidiasis 13.44 11.80 7 174686 73 34782165
Anorectal varices 13.44 11.80 6 174687 43 34782195
Suspected product quality issue 13.44 11.80 9 174684 154 34782084
Coronary artery stenosis 13.39 11.80 17 174676 9599 34772639
Non-Hodgkin's lymphoma recurrent 13.38 11.80 5 174688 21 34782217
Coxsackie viral infection 13.38 11.80 5 174688 21 34782217
Catheter site thrombosis 13.33 11.80 8 174685 112 34782126
Gastrointestinal lymphoma 13.32 11.80 6 174687 44 34782194
Abdominal neoplasm 13.31 11.80 13 174680 388 34781850
Retroperitoneal fibrosis 13.29 11.80 13 174680 389 34781849
Electrolyte imbalance 13.27 11.80 33 174660 14379 34767859
Peripheral T-cell lymphoma unspecified 13.24 11.80 14 174679 460 34781778
Emotional disorder 13.20 11.80 6 174687 5710 34776528
Ventricular extrasystoles 13.12 11.80 25 174668 11983 34770255
Sphingomonas paucimobilis infection 13.10 11.80 6 174687 46 34782192
Pulmonary hypertension 12.99 11.80 57 174636 20867 34761371
Haemorrhoids 12.94 11.80 34 174659 14541 34767697
Hepatitis B core antigen positive 12.91 11.80 3 174690 0 34782238
Splenic infection 12.91 11.80 3 174690 0 34782238
Larynx irritation 12.91 11.80 3 174690 0 34782238
Follicular lymphoma stage IV 12.91 11.80 3 174690 0 34782238
Diabetes mellitus 12.89 11.80 161 174532 46712 34735526
Emphysematous cholecystitis 12.88 11.80 6 174687 48 34782190
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 12.86 11.80 4 174689 8 34782230
Affective disorder 12.84 11.80 3 174690 4357 34777881
Autoimmune hepatitis 12.84 11.80 3 174690 4357 34777881
Granulocyte count decreased 12.82 11.80 18 174675 797 34781441
Rheumatoid factor increased 12.81 11.80 15 174678 553 34781685
Full blood count abnormal 12.75 11.80 49 174644 18619 34763619
Angiosarcoma 12.75 11.80 11 174682 279 34781959
Myeloid leukaemia 12.73 11.80 13 174680 410 34781828
Hypercholesterolaemia 12.72 11.80 15 174678 8747 34773491
Pain in jaw 12.69 11.80 29 174664 13011 34769227
Mantle cell lymphoma stage III 12.69 11.80 5 174688 25 34782213
Lacrimal duct neoplasm 12.69 11.80 5 174688 25 34782213
Renal transplant failure 12.56 11.80 21 174672 1085 34781153
Blood albumin decreased 12.56 11.80 31 174662 13541 34768697
Personality change 12.50 11.80 5 174688 5134 34777104
Platelet disorder 12.49 11.80 27 174666 1694 34780544
Cardiac failure acute 12.46 11.80 21 174672 10549 34771689
Haematocrit decreased 12.45 11.80 102 174591 32114 34750124
Drug level above therapeutic 12.42 11.80 3 174690 4258 34777980
Neuromyelitis optica spectrum disorder 12.41 11.80 8 174685 128 34782110
Infected neoplasm 12.38 11.80 7 174686 87 34782151
Sinus node dysfunction 12.36 11.80 3 174690 4246 34777992
BRAF gene mutation 12.28 11.80 6 174687 54 34782184
Neutrophil percentage decreased 12.27 11.80 12 174681 359 34781879
Paresis 12.26 11.80 31 174662 2155 34780083
Basophilia 12.25 11.80 4 174689 10 34782228
Metastases to muscle 12.23 11.80 10 174683 235 34782003
Splenic marginal zone lymphoma 12.22 11.80 5 174688 28 34782210
Refractory cytopenia with multilineage dysplasia 12.19 11.80 8 174685 132 34782106
Seronegative arthritis 12.16 11.80 20 174673 1019 34781219
Hydronephrosis 12.15 11.80 91 174602 10255 34771983
Transfusion 12.14 11.80 15 174678 8570 34773668
Staphylococcal bacteraemia 12.09 11.80 78 174615 8374 34773864
Joint range of motion decreased 12.05 11.80 70 174623 7242 34774996
Hypervolaemia 12.05 11.80 54 174639 19655 34762583
Blister 12.03 11.80 66 174627 22792 34759446
Blood creatinine increased 12.03 11.80 372 174321 94604 34687634
Phaeohyphomycosis 12.02 11.80 18 174675 846 34781392
Retroperitoneal mass 11.98 11.80 7 174686 93 34782145
Injection site rash 11.95 11.80 3 174690 4150 34778088
Neoplasm malignant 11.93 11.80 152 174541 19753 34762485
Fistula 11.89 11.80 10 174683 6830 34775408
Injection site extravasation 11.85 11.80 37 174656 2905 34779333
Jaundice 11.85 11.80 102 174591 31780 34750458
Metastases to retroperitoneum 11.84 11.80 10 174683 246 34781992
Diffuse large B-cell lymphoma stage III 11.82 11.80 6 174687 59 34782179
Immobilisation syndrome 11.81 11.80 11 174682 309 34781929

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 3175.82 10.99 12535 482438 894680 78354735
Drug ineffective 2536.03 10.99 13273 481700 1067640 78181775
Infusion related reaction 2407.66 10.99 4760 490213 225477 79023938
Drug intolerance 2176.16 10.99 4955 490018 259164 78990251
Contraindicated product administered 2054.65 10.99 3583 491390 153955 79095460
Treatment failure 1804.04 10.99 3544 491429 166942 79082473
Synovitis 1593.90 10.99 3133 491840 147601 79101814
Progressive multifocal leukoencephalopathy 1483.01 10.99 1140 493833 19460 79229955
Joint swelling 1456.36 10.99 4514 490459 284132 78965283
Completed suicide 1434.33 10.99 17 494956 245750 79003665
Intentional product use issue 1188.20 10.99 2797 492176 149315 79100100
Drug interaction 1184.84 10.99 548 494425 414635 78834780
Febrile neutropenia 1168.49 10.99 3617 491356 227382 79022033
Hand deformity 1155.33 10.99 2207 492766 101712 79147703
Arthropathy 1142.06 10.99 3027 491946 174084 79075331
Therapeutic product effect decreased 1139.27 10.99 2881 492092 160982 79088433
Hypogammaglobulinaemia 1137.55 10.99 808 494165 12143 79237272
Pemphigus 1096.07 10.99 2106 492867 97476 79151939
Toxicity to various agents 1051.33 10.99 660 494313 420880 78828535
Drug abuse 979.30 10.99 5 494968 162686 79086729
Systemic lupus erythematosus 973.52 10.99 2253 492720 118896 79130519
Anti-cyclic citrullinated peptide antibody positive 952.75 10.99 1789 493184 81354 79168061
Glossodynia 882.64 10.99 1969 493004 101368 79148047
Diffuse large B-cell lymphoma recurrent 874.49 10.99 456 494517 3751 79245664
Product dose omission issue 847.02 10.99 243 494730 247294 79002121
Rheumatoid factor positive 790.60 10.99 1370 493603 58469 79190946
Fall 705.16 10.99 1216 493757 486413 78763002
Pericarditis 698.33 10.99 1808 493165 102428 79146987
Infection 694.00 10.99 3156 491817 238556 79010859
Hepatitis B reactivation 691.49 10.99 446 494527 5662 79243753
Hepatitis B 681.80 10.99 498 494475 7834 79241581
Swelling 668.50 10.99 2891 492082 213820 79035595
Product use in unapproved indication 666.74 10.99 3198 491775 247161 79002254
Hepatic enzyme increased 664.51 10.99 2564 492409 180046 79069369
Intentional overdose 633.72 10.99 4 494969 105956 79143459
Wound 611.58 10.99 1846 493127 114333 79135082
Neutropenia 590.72 10.99 3420 491553 284290 78965125
Pneumocystis jirovecii pneumonia 590.47 10.99 861 494112 31647 79217768
Overdose 581.78 10.99 208 494765 183998 79065417
Cytomegalovirus infection 577.22 10.99 987 493986 41657 79207758
Alopecia 571.49 10.99 2893 492080 228462 79020953
Helicobacter infection 550.49 10.99 1288 493685 68416 79180999
Hypersensitivity 547.23 10.99 3131 491842 259108 78990307
Disease progression 539.18 10.99 2421 492552 181941 79067474
Red blood cell sedimentation rate increased 532.86 10.99 994 493979 44948 79204467
Rhabdomyolysis 528.04 10.99 27 494946 103104 79146311
Acute kidney injury 521.30 10.99 1578 493395 517826 78731589
Abdominal discomfort 514.89 10.99 2981 491992 247746 79001669
Drug effective for unapproved indication 512.26 10.99 368 494605 5633 79243782
Duodenal ulcer perforation 505.00 10.99 1207 493766 65004 79184411
Tumour lysis syndrome 481.93 10.99 666 494307 23273 79226142
Blood pressure diastolic abnormal 476.28 10.99 592 494381 18610 79230805
COVID-19 461.27 10.99 2071 492902 155603 79093812
Injection site pain 459.75 10.99 119 494854 129719 79119696
COVID-19 pneumonia 457.07 10.99 717 494256 28132 79221283
Blood pressure fluctuation 446.81 10.99 1162 493811 65983 79183432
Vomiting 441.40 10.99 2382 492591 663446 78585969
Ill-defined disorder 432.18 10.99 1134 493839 64741 79184674
Dizziness 427.81 10.99 1749 493224 524692 78724723
Hyponatraemia 420.27 10.99 295 494678 177553 79071862
Myelodysplastic syndrome 416.22 10.99 706 494267 29595 79219820
Musculoskeletal stiffness 415.58 10.99 2165 492808 172843 79076572
Discomfort 411.93 10.99 1708 493265 123909 79125506
Blood pressure systolic abnormal 410.67 10.99 521 494452 16726 79232689
Arthralgia 386.91 10.99 5323 489650 566480 78682935
Electrocardiogram QT prolonged 385.60 10.99 52 494921 90334 79159081
Somnolence 382.63 10.99 556 494417 238425 79010990
Dehydration 382.29 10.99 593 494380 247594 79001821
Hypoglycaemia 379.59 10.99 83 494890 101511 79147904
C-reactive protein abnormal 374.49 10.99 887 494086 47480 79201935
Suicide attempt 370.25 10.99 41 494932 82891 79166524
Throat irritation 368.36 10.99 797 494176 40149 79209266
International normalised ratio increased 363.19 10.99 48 494925 84673 79164742
Cardio-respiratory arrest 357.34 10.99 114 494859 108396 79141019
Death 353.24 10.99 2067 492906 564447 78684968
Constipation 352.70 10.99 770 494203 282280 78967135
C-reactive protein increased 351.55 10.99 1660 493313 127367 79122048
Bradycardia 336.19 10.99 213 494760 135344 79114071
Diarrhoea 322.38 10.99 3707 491266 876782 78372633
Blood pressure systolic increased 321.44 10.99 1031 493942 65955 79183460
Rheumatoid nodule 309.60 10.99 457 494516 16981 79232434
Cytopenia 308.29 10.99 496 494477 19887 79229528
Product use issue 305.20 10.99 2289 492684 207533 79041882
Lymphoma 303.42 10.99 453 494520 17007 79232408
Drug hypersensitivity 300.70 10.99 3005 491968 295911 78953504
Cardiac failure congestive 295.26 10.99 269 494704 142133 79107282
Cardiac arrest 289.76 10.99 386 494587 171710 79077705
Depressed level of consciousness 287.04 10.99 120 494853 96532 79152883
Seizure 286.12 10.99 456 494517 188378 79061037
Muscle injury 285.50 10.99 803 494170 47758 79201657
Hallucination 284.25 10.99 89 494884 85656 79163759
Folliculitis 282.83 10.99 871 494102 54509 79194906
Agitation 280.13 10.99 134 494839 99581 79149834
Intentional product misuse 278.07 10.99 121 494852 95044 79154371
Sleep disorder due to general medical condition, insomnia type 269.68 10.99 734 494239 42822 79206593
Irritable bowel syndrome 269.24 10.99 925 494048 61316 79188099
Therapy partial responder 268.13 10.99 427 494546 16970 79232445
Anxiety 267.80 10.99 729 494244 247783 79001632
Rheumatoid arthritis 264.57 10.99 2204 492769 206266 79043149
Suicidal ideation 264.46 10.99 73 494900 76267 79173148
Metabolic acidosis 264.19 10.99 91 494882 82438 79166977
Agranulocytosis 264.12 10.99 744 494229 44286 79205129
Myalgia 262.17 10.99 469 494504 185172 79064243
Myelosuppression 261.52 10.99 691 494282 39605 79209810
Sedation 258.17 10.99 16 494957 51879 79197536
Dyspnoea 255.33 10.99 3766 491207 853259 78396156
Post transplant lymphoproliferative disorder 255.22 10.99 335 494638 11129 79238286
Disease recurrence 255.02 10.99 725 494248 43384 79206031
Hyperkalaemia 251.89 10.99 204 494769 114194 79135221
Haematotoxicity 251.79 10.99 390 494583 15129 79234286
Coma 249.74 10.99 158 494815 100491 79148924
Oedema peripheral 248.58 10.99 772 494201 251516 78997899
Bone marrow failure 247.36 10.99 789 494184 50318 79199097
Diffuse large B-cell lymphoma refractory 246.36 10.99 137 494836 1298 79248117
Chronic lymphocytic leukaemia recurrent 244.83 10.99 106 494867 542 79248873
B-cell lymphoma recurrent 244.60 10.99 121 494852 879 79248536
Maternal exposure during pregnancy 242.92 10.99 1565 493408 134973 79114442
Inflammation 242.16 10.99 1188 493785 92565 79156850
Cerebrovascular accident 234.28 10.99 376 494597 154916 79094499
Inappropriate schedule of product administration 231.83 10.99 293 494680 133335 79116080
Wrong technique in product usage process 230.42 10.99 85 494888 73790 79175625
Myocardial infarction 229.95 10.99 500 494473 183629 79065786
Nausea 225.96 10.99 4388 490585 952808 78296607
Serum sickness 225.46 10.99 185 494788 3481 79245934
Accidental overdose 225.27 10.99 4 494969 39577 79209838
Epstein-Barr virus infection 223.78 10.99 355 494618 14061 79235354
Feeling abnormal 223.15 10.99 404 494569 158795 79090620
Ear pruritus 222.89 10.99 193 494780 3922 79245493
Therapeutic response decreased 222.17 10.99 913 494060 65940 79183475
Drug tolerance decreased 220.22 10.99 333 494640 12645 79236770
Granuloma skin 219.78 10.99 278 494695 8896 79240519
Injection site erythema 219.77 10.99 105 494868 78092 79171323
Panniculitis 217.88 10.99 323 494650 12048 79237367
Muscle spasms 216.11 10.99 477 494496 174253 79075162
Cytomegalovirus infection reactivation 214.99 10.99 268 494705 8448 79240967
Blood creatine phosphokinase increased 214.80 10.99 71 494902 66019 79183396
Respiratory arrest 212.97 10.99 48 494925 57502 79191913
Pain 212.53 10.99 5793 489180 698009 78551406
Loss of consciousness 211.41 10.99 454 494519 167489 79081926
Bone erosion 210.47 10.99 389 494584 17458 79231957
Hip arthroplasty 209.91 10.99 591 494382 35165 79214250
Blood parathyroid hormone decreased 208.87 10.99 291 494682 10245 79239170
Hospitalisation 208.77 10.99 167 494806 94069 79155346
Diffuse large B-cell lymphoma 207.95 10.99 313 494660 11836 79237579
Hypokalaemia 206.87 10.99 360 494613 143680 79105735
Hypotension 206.57 10.99 1744 493229 438573 78810842
Lactic acidosis 206.27 10.99 89 494884 70270 79179145
Oxygen saturation decreased 206.03 10.99 1440 493533 127607 79121808
Drug ineffective for unapproved indication 205.68 10.99 743 494230 50495 79198920
Plasma cell myeloma 204.09 10.99 41 494932 53218 79196197
Impaired healing 201.42 10.99 1075 493898 86580 79162835
B-lymphocyte count decreased 200.03 10.99 119 494854 1295 79248120
Rheumatic fever 198.32 10.99 502 494471 28023 79221392
JC virus infection 198.13 10.99 176 494797 3705 79245710
Therapy non-responder 196.65 10.99 1109 493864 91196 79158219
Drug withdrawal syndrome 195.59 10.99 4 494969 34714 79214701
Cytokine release syndrome 194.92 10.99 578 494395 35420 79213995
Haematochezia 192.06 10.99 157 494816 87488 79161927
Vision blurred 191.29 10.99 225 494748 105673 79143742
Basal cell carcinoma 190.05 10.99 587 494386 36788 79212627
Tremor 189.93 10.99 490 494483 169593 79079822
Aggression 189.57 10.99 42 494931 50916 79198499
Abdominal pain 189.50 10.99 1528 493445 388041 78861374
Unresponsive to stimuli 186.52 10.99 57 494916 55731 79193684
Gastrointestinal haemorrhage 184.52 10.99 401 494572 147318 79102097
Blister 183.03 10.99 1320 493653 118156 79131259
Incorrect dose administered 182.39 10.99 126 494847 76504 79172911
Coronary artery disease 182.34 10.99 89 494884 65385 79184030
Herpes zoster 181.20 10.99 1092 493881 91991 79157424
Dyskinesia 181.19 10.99 30 494943 44743 79204672
Humoral immune defect 180.19 10.99 76 494897 360 79249055
Asthenia 180.12 10.99 2171 492802 509518 78739897
Aspergillus infection 178.10 10.99 378 494595 18783 79230632
Pulmonary fibrosis 175.64 10.99 638 494335 43474 79205941
Foot deformity 175.07 10.99 431 494542 23643 79225772
Orthostatic hypotension 174.52 10.99 65 494908 56099 79193316
Swollen joint count increased 173.70 10.99 417 494556 22510 79226905
Interstitial lung disease 171.88 10.99 1243 493730 111357 79138058
Syncope 171.85 10.99 556 494417 178893 79070522
Intentional self-injury 170.75 10.99 7 494966 32412 79217003
Injection site swelling 169.09 10.99 42 494931 47090 79202325
Loss of personal independence in daily activities 167.45 10.99 1151 493822 101429 79147986
Blood pressure diastolic decreased 166.30 10.99 488 494485 29728 79219687
Second primary malignancy 162.01 10.99 307 494666 14043 79235372
Sopor 161.76 10.99 11 494962 32999 79216416
Emotional distress 161.25 10.99 27 494946 39942 79209473
Dry skin 160.24 10.99 113 494860 67882 79181533
Angioedema 159.51 10.99 142 494831 75893 79173522
Blood cholesterol increased 158.41 10.99 975 493998 82745 79166670
Mantle cell lymphoma recurrent 156.34 10.99 76 494897 529 79248886
Decreased appetite 156.11 10.99 1366 493607 341052 78908363
Diabetic ketoacidosis 154.51 10.99 16 494957 34106 79215309
Lower respiratory tract infection 153.71 10.99 1347 493626 127873 79121542
Coeliac disease 152.59 10.99 262 494711 11089 79238326
Knee arthroplasty 151.13 10.99 600 494373 42648 79206767
Lymphopenia 149.90 10.99 474 494499 30083 79219332
Pancytopenia 149.75 10.99 1631 493342 164114 79085301
Lethargy 148.66 10.99 171 494802 81121 79168294
Therapy cessation 147.98 10.99 27 494946 37535 79211880
Dysgeusia 147.07 10.99 86 494887 57091 79192324
Labelled drug-drug interaction medication error 145.53 10.99 6 494967 27644 79221771
Acute myocardial infarction 144.20 10.99 159 494814 76877 79172538
Disorientation 141.88 10.99 109 494864 62667 79186748
Abdominal distension 141.14 10.99 335 494638 119315 79130100
Bronchopulmonary aspergillosis 140.29 10.99 378 494595 21916 79227499
Epistaxis 139.02 10.99 303 494670 111212 79138203
Swelling face 138.86 10.99 142 494831 71070 79178345
Haematemesis 138.17 10.99 76 494897 52188 79197227
Product prescribing error 137.34 10.99 53 494920 44760 79204655
Ulcer 136.26 10.99 453 494520 29519 79219896
Immunodeficiency 135.89 10.99 368 494605 21400 79228015
Hallucination, visual 134.53 10.99 21 494952 32708 79216707
Stomatitis 134.34 10.99 1448 493525 145309 79104106
Neutropenic sepsis 133.85 10.99 421 494552 26643 79222772
Rash 132.44 10.99 4604 490369 573754 78675661
Palmar-plantar erythrodysaesthesia syndrome 132.31 10.99 23 494950 33111 79216304
Tachycardia 132.11 10.99 610 494363 177158 79072257
Skin necrosis 131.71 10.99 324 494649 17763 79231652
Injection site pruritus 131.26 10.99 49 494924 42234 79207181
Demyelination 130.68 10.99 202 494771 7821 79241594
Neutrophil count decreased 130.26 10.99 1014 493959 92945 79156470
Hyperglycaemia 129.64 10.99 147 494826 70188 79179227
Nasopharyngitis 128.70 10.99 2253 492720 251628 78997787
Arthritis 128.66 10.99 1182 493791 113698 79135717
Nightmare 128.55 10.99 8 494965 25853 79223562
Psoriatic arthropathy 127.76 10.99 876 494097 77123 79172292
Device issue 127.28 10.99 11 494962 27097 79222318
Febrile bone marrow aplasia 125.83 10.99 261 494712 12759 79236656
Chest pain 125.62 10.99 1133 493840 281171 78968244
Irritability 125.53 10.99 49 494924 41095 79208320
Rectal haemorrhage 125.46 10.99 174 494799 76126 79173289
Restlessness 125.26 10.99 66 494907 46426 79202989
Joint range of motion decreased 123.83 10.99 471 494502 32811 79216604
Gastrointestinal disorder 122.84 10.99 1229 493744 120976 79128439
Multiple sclerosis relapse 122.53 10.99 68 494905 46465 79202950
Osteonecrosis of jaw 121.51 10.99 58 494915 43168 79206247
Hepatitis E 120.83 10.99 119 494854 2867 79246548
Blood pressure increased 120.46 10.99 1912 493061 209448 79039967
Insomnia 120.28 10.99 959 494014 244211 79005204
Cytomegalovirus viraemia 119.24 10.99 253 494720 12568 79236847
Type 2 diabetes mellitus 118.80 10.99 682 494291 56440 79192975
Hypomagnesaemia 118.62 10.99 72 494901 46839 79202576
Urinary tract infection 118.13 10.99 1111 493862 273401 78976014
Withdrawal syndrome 118.03 10.99 14 494959 26840 79222575
Blood glucose increased 118.02 10.99 345 494628 114630 79134785
Pneumocystis jirovecii infection 116.48 10.99 115 494858 2779 79246636
Therapeutic product effect incomplete 116.23 10.99 1368 493605 140277 79109138
Extrapyramidal disorder 115.86 10.99 6 494967 22673 79226742
Dislocation of vertebra 115.41 10.99 189 494784 7691 79241724
Fibromyalgia 115.29 10.99 739 494234 63601 79185814
Balance disorder 114.83 10.99 279 494694 98578 79150837
Injection site haemorrhage 114.28 10.99 18 494955 27852 79221563
Swollen tongue 113.85 10.99 61 494912 42509 79206906
Apparent death 113.75 10.99 113 494860 2752 79246663
Melaena 113.60 10.99 126 494847 60764 79188651
Gastrooesophageal reflux disease 113.53 10.99 304 494669 103942 79145473
Product substitution issue 111.54 10.99 3 494970 20253 79229162
Heart rate decreased 110.62 10.99 782 494191 69534 79179881
Frequent bowel movements 110.57 10.99 24 494949 29515 79219900
Therapy interrupted 110.37 10.99 29 494944 31312 79218103
Sinusitis 109.69 10.99 1764 493209 193737 79055678
Flatulence 108.84 10.99 65 494908 42659 79206756
Mental status changes 108.79 10.99 154 494819 66805 79182610
Accidental exposure to product 108.38 10.99 30 494943 31292 79218123
SLE arthritis 108.38 10.99 59 494914 534 79248881
Smooth muscle cell neoplasm 108.28 10.99 70 494903 892 79248523
Acquired gene mutation 107.55 10.99 98 494875 2135 79247280
Back pain 107.43 10.99 1289 493684 302891 78946524
Lip swelling 107.41 10.99 60 494913 40851 79208564
Poisoning 106.67 10.99 15 494958 25257 79224158
Pneumonia cytomegaloviral 105.68 10.99 142 494831 4827 79244588
Abnormal behaviour 105.28 10.99 47 494926 36374 79213041
Ventricular tachycardia 105.15 10.99 65 494908 41870 79207545
Drug reaction with eosinophilia and systemic symptoms 105.13 10.99 147 494826 64097 79185318
Sciatica 104.33 10.99 446 494527 32776 79216639
Lymphoma transformation 102.31 10.99 47 494926 283 79249132
Urinary retention 101.52 10.99 121 494852 56509 79192906
Osteoarthritis 101.15 10.99 905 494068 86404 79163011
Pulmonary oedema 100.99 10.99 251 494722 88003 79161412
Blood calcium decreased 100.25 10.99 36 494937 31783 79217632
Pancreatitis acute 100.06 10.99 96 494877 49508 79199907
Blood alkaline phosphatase increased 99.92 10.99 150 494823 63514 79185901
Generalised tonic-clonic seizure 99.53 10.99 76 494897 43834 79205581
Depression 99.51 10.99 863 494110 215927 79033488
Adenovirus infection 99.45 10.99 184 494789 8263 79241152
Disturbance in attention 99.38 10.99 101 494872 50700 79198715
Product quality issue 99.36 10.99 43 494930 33897 79215518
Blood potassium decreased 98.59 10.99 86 494887 46426 79202989
Obstructive airways disorder 98.42 10.99 36 494937 31423 79217992
Paraesthesia 98.32 10.99 665 494308 175658 79073757
Hypophagia 97.24 10.99 83 494890 45284 79204131
Surgery 96.74 10.99 41 494932 32725 79216690
Confusional state 96.73 10.99 1390 493583 316607 78932808
Musculoskeletal deformity 96.69 10.99 79 494894 1477 79247938
Blood urea increased 95.45 10.99 97 494876 48693 79200722
Red blood cell sedimentation rate abnormal 95.43 10.99 317 494656 20646 79228769
Anaemia 94.38 10.99 2074 492899 442941 78806474
Gamma-glutamyltransferase increased 93.65 10.99 121 494852 54559 79194856
Acute myeloid leukaemia 93.44 10.99 410 494563 30475 79218940
Transient ischaemic attack 92.97 10.99 114 494859 52581 79196834
Elbow deformity 92.91 10.99 77 494896 1470 79247945
Injection site bruising 92.89 10.99 71 494902 40931 79208484
Palpitations 92.54 10.99 437 494536 126173 79123242
Blood bilirubin increased 91.93 10.99 169 494804 66063 79183352
Full blood count abnormal 91.81 10.99 70 494903 40404 79209011
Memory impairment 91.80 10.99 369 494604 111365 79138050
Dysarthria 91.70 10.99 175 494798 67447 79181968
Skin ulcer 90.96 10.99 612 494361 53538 79195877
Psychotic disorder 90.89 10.99 74 494899 41328 79208087
Depressed mood 90.79 10.99 100 494873 48380 79201035
Lymphadenopathy 90.77 10.99 604 494369 52643 79196772
Peripheral swelling 90.76 10.99 2253 492720 267364 78982051
Injection site mass 90.02 10.99 10 494963 20174 79229241
Septic shock 89.93 10.99 1161 493812 121640 79127775
Dystonia 89.63 10.99 13 494960 21386 79228029
Mobility decreased 89.44 10.99 1155 493818 121020 79128395
Joint stiffness 89.21 10.99 494 494479 40336 79209079
Creatinine renal clearance decreased 88.43 10.99 8 494965 18994 79230421
Hallucination, auditory 88.01 10.99 12 494961 20681 79228734
Chronic kidney disease 87.28 10.99 174 494799 65980 79183435
Pyrexia 87.14 10.99 5094 489879 673615 78575800
Leukopenia 86.78 10.99 1105 493868 115408 79134007
Posterior reversible encephalopathy syndrome 86.56 10.99 358 494615 25923 79223492
Red blood cell sedimentation rate 86.31 10.99 137 494836 5428 79243987
Chronic obstructive pulmonary disease 85.72 10.99 259 494714 85160 79164255
Circulatory collapse 85.63 10.99 65 494908 37603 79211812
Glomerulonephritis 85.38 10.99 106 494867 3327 79246088
Contrast media allergy 84.83 10.99 91 494882 2431 79246984
Autoimmune haemolytic anaemia 84.54 10.99 171 494802 8209 79241206
Gastric disorder 84.54 10.99 457 494516 36976 79212439
Disability 84.36 10.99 266 494707 16854 79232561
Head injury 84.29 10.99 65 494908 37304 79212111
Respiratory depression 84.13 10.99 33 494940 27597 79221818
Pancreatitis 84.08 10.99 188 494785 68387 79181028
Cytomegalovirus chorioretinitis 83.56 10.99 134 494839 5356 79244059
Device malfunction 83.24 10.99 16 494957 21432 79227983
Drug level increased 83.22 10.99 74 494899 39577 79209838
Obliterative bronchiolitis 82.64 10.99 98 494875 2930 79246485
Chills 82.57 10.99 1426 493547 158808 79090607
Malaise 82.56 10.99 2362 492611 487507 78761908
Skin exfoliation 82.49 10.99 134 494839 54966 79194449
Unevaluable event 82.45 10.99 136 494837 55449 79193966
Injection site rash 82.38 10.99 8 494965 17946 79231469
Seronegative arthritis 81.90 10.99 122 494851 4570 79244845
Myoclonus 81.04 10.99 35 494938 27625 79221790
Jaundice 80.57 10.99 129 494844 53220 79196195
Vertigo 80.19 10.99 195 494778 68887 79180528
Cerebral haemorrhage 80.19 10.99 147 494826 57526 79191889
Blood sodium decreased 80.03 10.99 54 494919 33201 79216214
Speech disorder 80.03 10.99 134 494839 54311 79195104
Hyperlipidaemia 79.72 10.99 31 494942 26062 79223353
Urinary incontinence 79.27 10.99 82 494891 40827 79208588
Vaccination failure 79.01 10.99 76 494897 1777 79247638
Cardiogenic shock 78.99 10.99 86 494887 41828 79207587
Meningoencephalitis viral 77.45 10.99 43 494930 406 79249009
Blood pressure diastolic increased 77.30 10.99 232 494741 14310 79235105
Post-acute COVID-19 syndrome 77.20 10.99 45 494928 470 79248945
Pneumonia aspiration 76.97 10.99 190 494783 66777 79182638
Muscle rigidity 76.81 10.99 15 494958 19867 79229548
Abdominal pain upper 76.50 10.99 955 494018 222864 79026551
Dyspnoea exertional 76.39 10.99 280 494693 86793 79162622
Product administration error 76.25 10.99 52 494921 31794 79217621
Cardiomegaly 76.17 10.99 34 494939 26318 79223097
Adverse event 75.39 10.99 635 494338 59579 79189836
Ureaplasma infection 75.31 10.99 58 494915 992 79248423
Product storage error 75.06 10.99 7 494966 16219 79233196
Breast cancer stage III 74.73 10.99 179 494794 9647 79239768
Temperature regulation disorder 74.64 10.99 132 494841 5721 79243694
Pseudomonas infection 74.64 10.99 292 494681 20611 79228804
Babesiosis 74.45 10.99 39 494934 324 79249091
Wrist deformity 74.07 10.99 78 494895 2039 79247376
Altered state of consciousness 73.99 10.99 98 494875 43724 79205691
Surgical failure 73.50 10.99 53 494920 816 79248599
Tenosynovitis 73.31 10.99 238 494735 15316 79234099
Metastases to bone 73.03 10.99 30 494943 24397 79225018
Pulmonary hypertension 72.85 10.99 116 494857 47964 79201451
Blood lactate dehydrogenase increased 72.70 10.99 454 494519 38716 79210699
Fear 72.53 10.99 23 494950 21963 79227452
Haemophagocytic lymphohistiocytosis 72.34 10.99 298 494675 21539 79227876
Abortion spontaneous 72.24 10.99 47 494926 29460 79219955
Atlantoaxial instability 71.93 10.99 36 494937 269 79249146
Chromaturia 71.67 10.99 35 494938 25711 79223704
Nodule 71.66 10.99 308 494665 22686 79226729
Cholelithiasis 71.66 10.99 136 494837 52528 79196887
Hypocalcaemia 71.43 10.99 125 494848 49799 79199616
Ventricular fibrillation 71.42 10.99 56 494917 31870 79217545
Hypervolaemia 70.53 10.99 97 494876 42593 79206822
Faeces discoloured 70.49 10.99 47 494926 29080 79220335
Grip strength decreased 69.75 10.99 295 494678 21574 79227841
Musculoskeletal disorder 69.72 10.99 291 494682 21157 79228258
Torsade de pointes 69.68 10.99 17 494956 19295 79230120
Intestinal sepsis 69.65 10.99 52 494921 847 79248568
Angina unstable 69.31 10.99 10 494963 16517 79232898
Hypercalcaemia 69.20 10.99 442 494531 37988 79211427
Prothrombin time prolonged 69.10 10.99 11 494962 16888 79232527
Delusion 68.02 10.99 21 494952 20402 79229013
Hypersomnia 67.98 10.99 29 494944 23057 79226358
Onychomycosis 67.75 10.99 155 494818 8106 79241309
Myocardial ischaemia 67.61 10.99 37 494936 25482 79223933
Mineral metabolism disorder 67.51 10.99 35 494938 284 79249131
Fine motor skill dysfunction 67.27 10.99 120 494853 5237 79244178
Blood potassium increased 67.21 10.99 50 494923 29225 79220190
Cerebral toxoplasmosis 67.04 10.99 78 494895 2284 79247131
Haemoptysis 66.64 10.99 156 494817 55843 79193572
Electrocardiogram abnormal 65.99 10.99 12 494961 16725 79232690
Renal failure 65.89 10.99 865 494108 200103 79049312
Blood iron abnormal 65.85 10.99 60 494913 1307 79248108
Central nervous system lymphoma 65.66 10.99 76 494897 2213 79247202
Metastases to liver 65.47 10.99 48 494925 28266 79221149
Upper gastrointestinal haemorrhage 65.42 10.99 97 494876 41283 79208132
Coombs positive haemolytic anaemia 65.29 10.99 55 494918 1075 79248340
Bone swelling 65.10 10.99 66 494907 1648 79247767
Gastrosplenic fistula 64.90 10.99 26 494947 105 79249310
Haematoma 64.88 10.99 142 494831 52053 79197362
Dysuria 64.68 10.99 137 494836 50814 79198601
Cognitive disorder 64.59 10.99 220 494753 69706 79179709
Mania 64.10 10.99 17 494956 18243 79231172
Device difficult to use 64.04 10.99 5 494968 13380 79236035
Injection site urticaria 63.65 10.99 4 494969 12822 79236593
Blood loss anaemia 63.57 10.99 10 494963 15488 79233927
BK virus infection 63.35 10.99 157 494816 8647 79240768
Mydriasis 62.74 10.99 16 494957 17627 79231788
Deformity 62.60 10.99 165 494808 9440 79239975
Transfusion 62.48 10.99 27 494946 21303 79228112
Eczema 62.30 10.99 98 494875 40720 79208695
Temperature intolerance 61.51 10.99 165 494808 9540 79239875
Intestinal obstruction 61.29 10.99 108 494865 42912 79206503
Infusion site reaction 61.22 10.99 91 494882 3402 79246013
Acidosis 61.17 10.99 23 494950 19739 79229676
Parkinsonism 61.01 10.99 14 494959 16570 79232845
Electric shock 61.01 10.99 58 494915 1336 79248079
Illness 60.78 10.99 123 494850 46388 79203027
Lymphadenitis 60.68 10.99 106 494867 4549 79244866
Cardiac disorder 60.66 10.99 207 494766 65550 79183865
Adjustment disorder with depressed mood 60.15 10.99 157 494816 8929 79240486
Iron deficiency anaemia 60.04 10.99 43 494930 25629 79223786
Joint destruction 59.89 10.99 121 494852 5804 79243611
Drug level decreased 59.74 10.99 9 494964 14393 79235022
Pollakiuria 59.46 10.99 87 494886 37230 79212185
Remission not achieved 59.37 10.99 35 494938 374 79249041
Mucosal inflammation 59.35 10.99 724 494249 74856 79174559
No adverse event 59.29 10.99 415 494558 36777 79212638
Toxic epidermal necrolysis 59.03 10.99 117 494856 44464 79204951
Systemic lupus erythematosus rash 58.88 10.99 65 494908 1795 79247620
Device dislocation 58.79 10.99 45 494928 25925 79223490
Liver injury 58.62 10.99 573 494400 56041 79193374
Cytomegalovirus test positive 58.39 10.99 120 494853 5827 79243588
West Nile viral infection 58.36 10.99 49 494924 953 79248462
Anger 58.34 10.99 17 494956 17145 79232270
Polyomavirus-associated nephropathy 58.17 10.99 116 494857 5511 79243904
Procedural pain 57.57 10.99 36 494937 23048 79226367
Injection site warmth 57.56 10.99 11 494962 14796 79234619
Bacteraemia 57.55 10.99 375 494598 32449 79216966
Immune effector cell-associated neurotoxicity syndrome 57.42 10.99 118 494855 5730 79243685
Impaired quality of life 57.41 10.99 10 494963 14376 79235039
Sinus tachycardia 56.91 10.99 88 494885 36820 79212595
Schizophrenia 56.87 10.99 13 494960 15427 79233988
Sinus bradycardia 56.83 10.99 44 494929 25203 79224212
Sleep disorder due to a general medical condition 56.81 10.99 10 494963 14267 79235148
Deep vein thrombosis postoperative 56.64 10.99 171 494802 10581 79238834
Salivary hypersecretion 56.51 10.99 10 494963 14214 79235201
Encephalitis cytomegalovirus 56.43 10.99 51 494922 1099 79248316
Spinal instability 56.14 10.99 35 494938 417 79248998
Bronchitis chronic 55.77 10.99 100 494873 4382 79245033
Blood immunoglobulin G decreased 55.76 10.99 86 494887 3323 79246092
Venoocclusive liver disease 55.37 10.99 180 494793 11591 79237824
Cerebral infarction 55.35 10.99 126 494847 45550 79203865
Cystitis haemorrhagic 55.20 10.99 153 494820 9019 79240396
Physical disability 55.07 10.99 84 494889 3214 79246201
Blood glucose decreased 55.00 10.99 49 494924 26185 79223230
Electrocardiogram QRS complex prolonged 54.92 10.99 3 494970 10830 79238585
Sepsis 54.92 10.99 2118 492855 267310 78982105
Secondary immunodeficiency 54.89 10.99 83 494890 3151 79246264
Liver function test abnormal 54.82 10.99 210 494763 64265 79185150
Needle issue 54.59 10.99 8 494965 13060 79236355
Hyperhidrosis 54.55 10.99 639 494334 150853 79098562
Tubulointerstitial nephritis 54.46 10.99 96 494877 38139 79211276
Headache 54.46 10.99 3414 491559 650358 78599057
Stevens-Johnson syndrome 54.29 10.99 100 494873 39066 79210349
Hepatic function abnormal 54.19 10.99 251 494722 72856 79176559
Right ventricular failure 54.11 10.99 40 494933 23457 79225958
Caesarean section 53.95 10.99 7 494966 12528 79236887
Mental disorder 53.88 10.99 69 494904 31233 79218182
Ageusia 53.80 10.99 18 494955 16614 79232801
Burning sensation 53.79 10.99 185 494788 58447 79190968
Immunoglobulins decreased 53.73 10.99 57 494916 1503 79247912
Pharyngeal paraesthesia 53.70 10.99 75 494898 2646 79246769
Hyperthyroidism 53.53 10.99 36 494937 22173 79227242
Haemodialysis 53.21 10.99 23 494950 18145 79231270
Post procedural complication 53.04 10.99 42 494931 23787 79225628
Influenza like illness 52.67 10.99 247 494726 71460 79177955
Nasal congestion 52.59 10.99 270 494703 76282 79173133
Haematocrit decreased 52.58 10.99 199 494774 61113 79188302
Anticipatory anxiety 52.51 10.99 50 494923 1154 79248261
Presyncope 52.43 10.99 110 494863 40944 79208471
Hypoxia 52.37 10.99 400 494573 102843 79146572
Thirst 52.30 10.99 25 494948 18594 79230821
Migraine 52.29 10.99 323 494650 87170 79162245
Pneumonia adenoviral 52.15 10.99 35 494938 477 79248938
Gait disturbance 51.74 10.99 941 494032 206565 79042850
Vasculitis 51.72 10.99 299 494674 24803 79224612
Herpes simplex 51.70 10.99 180 494793 12007 79237408
Pulmonary arterial hypertension 51.49 10.99 60 494913 28306 79221109
Encephalitis enteroviral 51.25 10.99 23 494950 130 79249285
Epstein-Barr virus infection reactivation 51.25 10.99 61 494912 1831 79247584
Mitral valve incompetence 51.23 10.99 61 494912 28504 79220911
X-ray abnormal 50.95 10.99 112 494861 5701 79243714
Blood immunoglobulin M decreased 50.81 10.99 51 494922 1258 79248157
B-cell lymphoma refractory 50.69 10.99 23 494950 134 79249281
Shock 50.48 10.99 123 494850 43425 79205990
5q minus syndrome 50.37 10.99 28 494945 265 79249150
Dermatitis atopic 50.32 10.99 3 494970 10053 79239362
Nervousness 50.26 10.99 81 494892 33334 79216081
Platelet count abnormal 49.99 10.99 100 494873 4762 79244653
Coagulopathy 49.85 10.99 92 494881 35914 79213501
Retinitis 49.77 10.99 109 494864 5534 79243881
Visual acuity reduced 49.65 10.99 66 494907 29403 79220012
Visual impairment 49.58 10.99 351 494622 91780 79157635
Underdose 49.27 10.99 81 494892 33070 79216345
Delirium 49.25 10.99 315 494658 84312 79165103
Adenoviral hepatitis 49.24 10.99 43 494930 884 79248531
Monocyte count increased 49.23 10.99 162 494811 10499 79238916
Blood creatinine increased 49.13 10.99 672 494301 154385 79095030
Skin discolouration 49.08 10.99 114 494859 40920 79208495
Injection site induration 48.92 10.99 3 494970 9816 79239599
Psoriasis 48.85 10.99 340 494633 89247 79160168
Colitis ulcerative 48.79 10.99 88 494885 34654 79214761
Campylobacter infection 48.72 10.99 59 494914 1804 79247611
Thrombocytopenia 48.69 10.99 2062 492911 263197 78986218
Terminal state 48.41 10.99 99 494874 4790 79244625
Pain in extremity 48.41 10.99 1812 493161 362726 78886689
Anaphylactic shock 48.06 10.99 94 494879 35902 79213513
Adenovirus reactivation 48.01 10.99 30 494943 359 79249056
Rhinitis allergic 47.94 10.99 9 494964 12260 79237155
Treatment noncompliance 47.89 10.99 165 494808 52103 79197312
Thyroid neoplasm 47.85 10.99 77 494896 3087 79246328
Tumour flare 47.77 10.99 46 494927 1077 79248338
Chronic lymphocytic leukaemia 47.56 10.99 98 494875 4768 79244647
Lung disorder 47.45 10.99 733 494240 79824 79169591
Haemorrhage 47.17 10.99 351 494622 90767 79158648
Dialysis 47.14 10.99 28 494945 18434 79230981
Spinal column injury 47.03 10.99 63 494910 2135 79247280
Poor quality sleep 46.97 10.99 43 494930 22679 79226736
Candida infection 46.78 10.99 401 494572 37813 79211602
Incorrect product administration duration 46.59 10.99 9 494964 12013 79237402
Cellulitis 46.58 10.99 442 494531 108618 79140797
Bursitis 46.47 10.99 381 494592 35463 79213952
Episcleritis 46.37 10.99 44 494929 1011 79248404
End stage renal disease 46.33 10.99 174 494799 12046 79237369
Finger deformity 46.29 10.99 126 494847 7348 79242067
Polyomavirus viraemia 46.18 10.99 55 494918 1652 79247763
Mantle cell lymphoma refractory 45.92 10.99 20 494953 104 79249311
Hip fracture 45.86 10.99 75 494898 30686 79218729
Microsporidia infection 45.75 10.99 42 494931 924 79248491
Gene mutation 45.68 10.99 69 494904 2617 79246798
Erectile dysfunction 45.50 10.99 17 494956 14647 79234768
Mesenteritis 45.46 10.99 28 494945 326 79249089
Electrolyte imbalance 45.39 10.99 76 494897 30805 79218610
Inappropriate antidiuretic hormone secretion 45.29 10.99 58 494915 26255 79223160
Food allergy 45.17 10.99 159 494814 10665 79238750
Herpes simplex encephalitis 44.97 10.99 37 494936 699 79248716
Sudden death 44.89 10.99 44 494929 22467 79226948
Cardiac failure 44.88 10.99 683 494290 154159 79095256
Paranoia 44.85 10.99 33 494940 19399 79230016
Blood immunoglobulin A decreased 44.66 10.99 50 494923 1403 79248012
Acute generalised exanthematous pustulosis 44.30 10.99 26 494947 17228 79232187
Prostatic specific antigen increased 44.22 10.99 6 494967 10380 79239035
Arteriosclerosis coronary artery 44.13 10.99 28 494945 17788 79231627
Complication associated with device 44.03 10.99 27 494946 17469 79231946
Staphylococcal bacteraemia 43.88 10.99 171 494802 12047 79237368
Mean platelet volume decreased 43.71 10.99 69 494904 2721 79246694
Tricuspid valve incompetence 43.56 10.99 35 494938 19677 79229738
Dermatitis contact 43.31 10.99 8 494965 11025 79238390
Hypokinesia 43.18 10.99 33 494940 19027 79230388
Panic attack 43.12 10.99 52 494921 24164 79225251
Laryngeal disorder 43.09 10.99 43 494930 1053 79248362
Subarachnoid haemorrhage 43.08 10.99 53 494920 24412 79225003
Mantle cell lymphoma 42.98 10.99 48 494925 1343 79248072
Chronic lymphocytic leukaemia refractory 42.40 10.99 19 494954 107 79249308
Rash papular 42.38 10.99 44 494929 21872 79227543
Cerebral aspergillosis 42.35 10.99 54 494919 1742 79247673
JC polyomavirus test positive 42.33 10.99 51 494922 1551 79247864
Full blood count decreased 42.26 10.99 63 494910 26756 79222659
Coma scale abnormal 42.20 10.99 3 494970 8675 79240740
Respiratory acidosis 42.12 10.99 9 494964 11191 79238224
Drug tolerance 42.02 10.99 134 494839 8541 79240874
Stress 42.02 10.99 305 494668 79307 79170108
Cataract 42.01 10.99 579 494394 61541 79187874
Prescribed overdose 41.99 10.99 389 494584 37494 79211921
Activated partial thromboplastin time prolonged 41.69 10.99 18 494955 14210 79235205
Miosis 41.67 10.99 23 494950 15766 79233649
SARS-CoV-2 antibody test negative 41.62 10.99 23 494950 215 79249200
Onychomadesis 41.50 10.99 97 494876 5145 79244270
Eye pain 41.34 10.99 109 494864 37469 79211946
Pallor 41.31 10.99 165 494808 49897 79199518
Asthma 40.84 10.99 591 494382 134504 79114911
Dementia 40.76 10.99 56 494917 24603 79224812
Abdominal pain lower 40.72 10.99 85 494888 31697 79217718
Haematuria 40.68 10.99 255 494718 68581 79180834
Gastritis 40.36 10.99 157 494816 47836 79201579
Ascites 40.11 10.99 289 494684 75273 79174142
Human herpesvirus 6 infection 39.95 10.99 97 494876 5273 79244142
Blood triglycerides increased 39.83 10.99 43 494930 20997 79228418
Therapeutic response unexpected 39.76 10.99 39 494934 19907 79229508
Anti-cyclic citrullinated peptide antibody 39.64 10.99 102 494871 5750 79243665
Chronic lymphocytic leukaemia transformation 39.24 10.99 23 494950 243 79249172
Pelvic pain 39.09 10.99 17 494956 13364 79236051
Acute respiratory failure 38.67 10.99 214 494759 59327 79190088
Arthritis bacterial 38.55 10.99 135 494838 9031 79240384
Red cell distribution width decreased 38.48 10.99 55 494918 1983 79247432
Lymphocytosis 38.43 10.99 88 494885 4605 79244810
Arthrodesis 38.36 10.99 60 494913 2347 79247068
Autoimmune disorder 38.31 10.99 204 494769 16408 79233007
Dizziness postural 38.24 10.99 12 494961 11537 79237878
Haemorrhoids 38.08 10.99 77 494896 29051 79220364
Heparin-induced thrombocytopenia 38.05 10.99 7 494966 9675 79239740
Atrioventricular block first degree 37.90 10.99 15 494958 12476 79236939
Mood altered 37.82 10.99 33 494940 17814 79231601
Ankle operation 37.82 10.99 40 494933 1051 79248364
Ventricular extrasystoles 37.61 10.99 40 494933 19664 79229751
Nocturia 37.48 10.99 19 494954 13662 79235753
Cytomegalovirus colitis 37.42 10.99 87 494886 4598 79244817
Pseudomonal bacteraemia 37.37 10.99 68 494905 3014 79246401
Facet joint syndrome 37.25 10.99 154 494819 11148 79238267
Varicella zoster virus infection 37.17 10.99 84 494889 4357 79245058
Immunodeficiency common variable 37.11 10.99 25 494948 343 79249072
Arteriosclerosis 37.08 10.99 35 494938 18192 79231223
Subdural haematoma 37.05 10.99 88 494885 31346 79218069
Vascular access complication 37.03 10.99 56 494917 2126 79247289
Pneumonia viral 36.91 10.99 133 494840 9025 79240390
Bunion operation 36.78 10.99 37 494936 915 79248500
Weight increased 36.59 10.99 2088 492885 275298 78974117
Thinking abnormal 36.47 10.99 18 494955 13143 79236272
Device leakage 36.45 10.99 11 494962 10845 79238570
Drug level below therapeutic 36.44 10.99 8 494965 9762 79239653
Middle insomnia 36.18 10.99 28 494945 16041 79233374
Platelet count decreased 36.10 10.99 1515 493458 193149 79056266
Arrhythmia 35.68 10.99 228 494745 61044 79188371
Dermatitis acneiform 35.66 10.99 9 494964 9984 79239431
Haemorrhagic stroke 35.65 10.99 12 494961 11034 79238381
Atrial fibrillation 35.60 10.99 945 494028 196941 79052474
Wound infection 35.52 10.99 263 494710 23728 79225687
Infusion site pain 35.50 10.99 22 494951 14154 79235261
Micturition urgency 35.47 10.99 17 494956 12624 79236791
Hyperbilirubinaemia 35.43 10.99 61 494912 24457 79224958
Electrocardiogram ST segment elevation 35.40 10.99 5 494968 8392 79241023
Encephalitis viral 35.29 10.99 60 494913 2519 79246896
Epstein-Barr viraemia 35.19 10.99 55 494918 2150 79247265
Viral haemorrhagic cystitis 35.13 10.99 53 494920 2008 79247407
Acute hepatitis B 35.05 10.99 27 494946 462 79248953
Pain of skin 34.80 10.99 24 494949 14589 79234826
B-cell lymphoma 34.79 10.99 101 494872 6114 79243301
Chest discomfort 34.71 10.99 625 494348 137419 79111996
Musculoskeletal pain 34.58 10.99 856 494117 101498 79147917
Anaphylactic reaction 34.43 10.99 720 494253 83023 79166392
Hypothermia 34.34 10.99 55 494918 22691 79226724
Sputum discoloured 34.34 10.99 51 494922 21692 79227723
Maternal exposure timing unspecified 34.25 10.99 96 494877 5696 79243719
Cholestasis 34.00 10.99 187 494786 51922 79197493
Vaginal haemorrhage 33.66 10.99 52 494921 21765 79227650
Troponin increased 33.60 10.99 42 494931 19213 79230202
Ischaemic stroke 33.56 10.99 100 494873 33031 79216384
Oral pruritus 33.56 10.99 57 494916 2391 79247024
Psychomotor hyperactivity 33.52 10.99 33 494940 16816 79232599
Squamous cell carcinoma 33.45 10.99 188 494785 15434 79233981
Neuroendocrine carcinoma of the skin 33.42 10.99 41 494932 1271 79248144
Drug resistance 33.41 10.99 405 494568 41808 79207607
Enterococcal infection 33.23 10.99 188 494785 15472 79233943
Eating disorder 33.22 10.99 48 494925 20649 79228766
Lipase increased 33.05 10.99 32 494941 16434 79232981
Bundle branch block left 33.05 10.99 15 494958 11498 79237917
Catatonia 33.00 10.99 7 494966 8749 79240666
Medication error 32.92 10.99 270 494703 68372 79181043
Eye swelling 32.90 10.99 72 494901 26396 79223019
Immunosuppression 32.86 10.99 162 494811 12641 79236774
Cerebral haematoma 32.86 10.99 5 494968 7937 79241478
Urine output decreased 32.84 10.99 38 494935 17984 79231431
Expired product administered 32.73 10.99 3 494970 7048 79242367
Paraneoplastic pemphigus 32.68 10.99 17 494956 139 79249276
Haemoglobin decreased 32.67 10.99 1090 493883 221029 79028386
Joint arthroplasty 32.65 10.99 60 494913 2680 79246735
Duodenal ulcer 32.64 10.99 32 494941 16337 79233078
Enterococcal bacteraemia 32.63 10.99 64 494909 3004 79246411
Rash macular 32.42 10.99 83 494890 28816 79220599
Leukocytosis 32.32 10.99 149 494824 43306 79206109
Drug-induced liver injury 32.20 10.99 259 494714 65858 79183557
Blood immunoglobulin M increased 32.10 10.99 41 494932 1325 79248090
Fluid retention 31.95 10.99 278 494695 69531 79179884
Bradyphrenia 31.92 10.99 13 494960 10627 79238788
Blood albumin decreased 31.77 10.99 64 494909 24179 79225236
Enterovirus infection 31.68 10.99 49 494924 1898 79247517
Dysstasia 31.66 10.99 79 494894 27667 79221748
Appendicitis 31.66 10.99 50 494923 20744 79228671
Euphoric mood 31.65 10.99 5 494968 7721 79241694
Eructation 31.65 10.99 14 494959 10895 79238520
Cholecystitis chronic 31.56 10.99 11 494962 9895 79239520
Rib fracture 31.56 10.99 80 494893 27867 79221548
Bipolar disorder 31.55 10.99 5 494968 7702 79241713
Left ventricular hypertrophy 31.47 10.99 15 494958 11176 79238239
International normalised ratio decreased 31.36 10.99 6 494967 8064 79241351
Cytology abnormal 31.34 10.99 22 494951 324 79249091
Hyperpyrexia 31.26 10.99 96 494877 5996 79243419
Prescribed underdose 31.18 10.99 300 494673 29214 79220201
Soft tissue disorder 31.12 10.99 68 494905 3447 79245968
Hypothyroidism 31.00 10.99 194 494779 52198 79197217
Epstein-Barr virus associated lymphoproliferative disorder 30.90 10.99 68 494905 3464 79245951
Pulse absent 30.87 10.99 12 494961 10091 79239324
Drug level above therapeutic 30.85 10.99 8 494965 8715 79240700
Mixed liver injury 30.83 10.99 5 494968 7573 79241842
Herpes oesophagitis 30.74 10.99 23 494950 376 79249039
Lip dry 30.70 10.99 182 494791 15236 79234179
Pericardial effusion 30.68 10.99 165 494808 46072 79203343
Renal impairment 30.65 10.99 745 494228 157038 79092377
Chronic allograft nephropathy 30.60 10.99 45 494928 1666 79247749
Eosinophilia 30.54 10.99 161 494812 45184 79204231
Hepatitis B surface antigen positive 30.49 10.99 17 494956 162 79249253
Pemphigoid 30.47 10.99 30 494943 15285 79234130
Oesophagitis 30.25 10.99 66 494907 24223 79225192
Coxsackie viral infection 30.24 10.99 12 494961 47 79249368
Pulseless electrical activity 30.23 10.99 26 494947 14134 79235281
Sarcoidosis 30.22 10.99 117 494856 8218 79241197
Skin irritation 30.21 10.99 16 494957 11224 79238191
Meningitis cryptococcal 30.11 10.99 67 494906 3439 79245976
Hypercapnia 30.10 10.99 9 494964 8926 79240489
Apathy 30 10.99 22 494951 12955 79236460
Choking 30.00 10.99 19 494954 12082 79237333
Organising pneumonia 29.94 10.99 141 494832 10798 79238617
Aspartate aminotransferase increased 29.92 10.99 644 494329 137997 79111418
Face oedema 29.91 10.99 83 494890 28053 79221362
Epilepsy 29.85 10.99 141 494832 40719 79208696
Pulmonary thrombosis 29.82 10.99 152 494821 12019 79237396
Mental impairment 29.72 10.99 45 494928 18991 79230424
B-cell aplasia 29.71 10.99 18 494955 203 79249212
Bladder cancer 29.68 10.99 47 494926 19479 79229936
Personality change 29.59 10.99 13 494960 10157 79239258
Neck deformity 29.57 10.99 46 494927 1791 79247624
Nasal polyps 29.44 10.99 5 494968 7322 79242093
Hypovolaemia 29.42 10.99 40 494933 17651 79231764
Atrioventricular block second degree 29.36 10.99 5 494968 7307 79242108
Epstein-Barr virus associated lymphoma 29.32 10.99 35 494938 1054 79248361
Traumatic lung injury 29.31 10.99 53 494920 2338 79247077
Rhinorrhoea 29.30 10.99 316 494657 75758 79173657
CD4 lymphocytes decreased 29.30 10.99 56 494917 2578 79246837
Refractory anaemia with an excess of blasts 29.27 10.99 32 494941 874 79248541
Gastric stenosis 29.19 10.99 16 494957 147 79249268
Tongue disorder 29.14 10.99 167 494806 13808 79235607
Ammonia increased 28.99 10.99 6 494967 7629 79241786
Condition aggravated 28.96 10.99 3543 491430 497581 78751834
Hypertriglyceridaemia 28.93 10.99 22 494951 12718 79236697
Cytomegalovirus enterocolitis 28.84 10.99 43 494930 1612 79247803
Osteoporosis 28.73 10.99 484 494489 53628 79195787
Complication of device insertion 28.69 10.99 3 494970 6347 79243068
Leukoerythroblastosis 28.63 10.99 20 494953 292 79249123
Central nervous system enteroviral infection 28.61 10.99 13 494960 76 79249339
Colorectal cancer 28.60 10.99 9 494964 8638 79240777
Ankle arthroplasty 28.57 10.99 41 494932 1484 79247931
Major depression 28.56 10.99 10 494963 8970 79240445
Breast cancer female 28.41 10.99 18 494955 11443 79237972
Heavy menstrual bleeding 28.39 10.99 27 494946 13984 79235431
Gestational diabetes 28.36 10.99 3 494970 6290 79243125
Renal transplant failure 28.28 10.99 46 494927 1861 79247554
Brain natriuretic peptide increased 28.15 10.99 10 494963 8890 79240525
Oliguria 28.02 10.99 36 494937 16273 79233142
Lymphoplasmacytoid lymphoma/immunocytoma 27.94 10.99 11 494962 42 79249373
Steroid diabetes 27.89 10.99 65 494908 3441 79245974
Concussion 27.88 10.99 12 494961 9491 79239924
Nocardiosis 27.76 10.99 88 494885 5591 79243824
Anuria 27.76 10.99 55 494918 20908 79228507
Potentiating drug interaction 27.74 10.99 10 494963 8809 79240606
Metabolic encephalopathy 27.72 10.99 11 494962 9136 79240279
Parosmia 27.72 10.99 5 494968 7009 79242406
Polydipsia 27.69 10.99 4 494969 6601 79242814
Blood calcium increased 27.66 10.99 15 494958 10385 79239030
Nephrogenic systemic fibrosis 27.60 10.99 3 494970 6157 79243258
Impaired work ability 27.59 10.99 213 494760 19468 79229947
Polyarthritis 27.57 10.99 149 494824 12053 79237362
Strongyloidiasis 27.51 10.99 69 494904 3829 79245586
Campylobacter gastroenteritis 27.50 10.99 38 494935 1327 79248088
Haemolysis 27.31 10.99 154 494819 12658 79236757
Incoherent 27.31 10.99 7 494966 7685 79241730
Initial insomnia 27.30 10.99 5 494968 6933 79242482
Hyperreflexia 27.25 10.99 9 494964 8376 79241039
Muscle twitching 27.11 10.99 72 494901 24692 79224723
Rheumatoid factor increased 27.11 10.99 44 494929 1777 79247638
Crystal nephropathy 27.08 10.99 39 494934 1416 79247999
Wrong product administered 27.05 10.99 11 494962 9001 79240414
Coronary artery bypass 27.04 10.99 3 494970 6059 79243356
Eyelid oedema 27.01 10.99 27 494946 13660 79235755
Muscular weakness 26.98 10.99 775 494198 159954 79089461
Autoimmune lymphoproliferative syndrome 26.98 10.99 16 494957 173 79249242
Cyanosis 26.98 10.99 74 494899 25108 79224307
Pruritus allergic 26.78 10.99 38 494935 1361 79248054
Marginal zone lymphoma recurrent 26.73 10.99 10 494963 32 79249383
Product complaint 26.73 10.99 26 494947 13323 79236092
Breast cancer metastatic 26.64 10.99 10 494963 8592 79240823
Retching 26.59 10.99 42 494931 17425 79231990
Intervertebral discitis 26.58 10.99 78 494895 4750 79244665
Hypomania 26.52 10.99 7 494966 7537 79241878
Seasonal allergy 26.38 10.99 38 494935 16368 79233047
Eye pruritus 26.36 10.99 55 494918 20515 79228900
Vasogenic cerebral oedema 26.32 10.99 39 494934 1454 79247961
Tinnitus 26.31 10.99 164 494809 44169 79205246
Anti-neutrophil cytoplasmic antibody positive vasculitis 26.31 10.99 66 494907 3663 79245752
Ketoacidosis 26.29 10.99 8 494965 7846 79241569
Colitis ischaemic 26.28 10.99 34 494939 15325 79234090
Anovulatory cycle 26.16 10.99 14 494959 122 79249293
Encephalitis 26.10 10.99 169 494804 14591 79234824
Pulmonary toxicity 26.07 10.99 153 494820 12761 79236654
Extrasystoles 25.87 10.99 7 494966 7412 79242003
Carotid artery stenosis 25.79 10.99 11 494962 8747 79240668
Cystitis viral 25.79 10.99 27 494946 701 79248714
Therapy change 25.76 10.99 7 494966 7392 79242023
Peripheral coldness 25.67 10.99 37 494936 15933 79233482
Nail disorder 25.62 10.99 143 494830 11709 79237706
Alanine aminotransferase abnormal 25.53 10.99 116 494857 8751 79240664
Hiatus hernia 25.35 10.99 68 494905 23244 79226171
Gastritis bacterial 25.30 10.99 20 494953 356 79249059
Dyspnoea at rest 25.25 10.99 7 494966 7295 79242120
Carotid artery occlusion 25.22 10.99 8 494965 7639 79241776
Affective disorder 25.22 10.99 10 494963 8309 79241106
Insurance issue 25.17 10.99 3 494970 5730 79243685
White blood cell count decreased 25.14 10.99 1419 493554 186869 79062546
C-reactive protein 25.12 10.99 78 494895 4901 79244514
Blood pressure decreased 25.10 10.99 450 494523 99016 79150399
Coronary artery occlusion 25.09 10.99 35 494938 15280 79234135
Neutropenic infection 25.05 10.99 50 494923 2377 79247038
Alanine aminotransferase increased 25.04 10.99 793 494180 161777 79087638
Macular degeneration 25.03 10.99 20 494953 11276 79238139
Cardiomyopathy 24.96 10.99 281 494692 28493 79220922
Bacterial sepsis 24.92 10.99 109 494864 8089 79241326
Head discomfort 24.92 10.99 32 494941 14470 79234945
Hypernatraemia 24.72 10.99 32 494941 14419 79234996
Joint dislocation 24.68 10.99 185 494788 16754 79232661
Malignant transformation 24.68 10.99 34 494939 1184 79248231
Amnesia 24.66 10.99 261 494712 62796 79186619
Bone density abnormal 24.64 10.99 57 494916 3003 79246412
Shock haemorrhagic 24.58 10.99 55 494918 20005 79229410
Renal injury 24.56 10.99 42 494931 16885 79232530
Ocular hyperaemia 24.54 10.99 91 494882 28115 79221300
Erythema multiforme 24.52 10.99 45 494928 17606 79231809
Joint injury 24.52 10.99 300 494673 31035 79218380
Endophthalmitis 24.52 10.99 5 494968 6423 79242992
Mean cell volume decreased 24.50 10.99 77 494896 4870 79244545
Groin pain 24.47 10.99 27 494946 13053 79236362
Metastases to central nervous system 24.34 10.99 40 494933 16335 79233080
Cardiac failure chronic 24.32 10.99 20 494953 11115 79238300
Antineutrophil cytoplasmic antibody positive 24.30 10.99 35 494938 1271 79248144
Glycosylated haemoglobin increased 24.26 10.99 52 494921 19208 79230207
Neoplasm malignant 24.22 10.99 303 494670 31507 79217908
Product dose omission in error 24.21 10.99 9 494964 7779 79241636
Fracture 24.16 10.99 63 494910 21738 79227677
Pulmonary embolism 24.15 10.99 847 494126 170807 79078608
Incorrect route of product administration 24.10 10.99 123 494850 34806 79214609
Faecal calprotectin increased 24.08 10.99 3 494970 5538 79243877
Diverticulitis 24.07 10.99 410 494563 45526 79203889
Pneumonia 24.04 10.99 4548 490425 655698 78593717
Myeloid leukaemia 23.87 10.99 26 494947 707 79248708
Allergy to chemicals 23.80 10.99 51 494922 2551 79246864
Pneumonia bacterial 23.74 10.99 203 494770 19128 79230287
Hysterectomy 23.67 10.99 5 494968 6267 79243148
Device failure 23.61 10.99 5 494968 6256 79243159
Drug dose omission by device 23.55 10.99 5 494968 6245 79243170
Hepatitis C RNA increased 23.53 10.99 20 494953 396 79249019
Gastrointestinal sounds abnormal 23.48 10.99 3 494970 5432 79243983
Precancerous cells present 23.42 10.99 33 494940 1174 79248241
Chromosomal deletion 23.40 10.99 14 494959 154 79249261
Aspiration 23.31 10.99 57 494916 20101 79229314
Erythropoiesis abnormal 23.22 10.99 21 494952 453 79248962
Sweat gland tumour 23.17 10.99 22 494951 506 79248909
Supraventricular tachycardia 23.17 10.99 62 494911 21208 79228207
Blood pressure inadequately controlled 23.16 10.99 5 494968 6172 79243243
Tooth disorder 23.13 10.99 257 494716 25976 79223439
Mean cell haemoglobin decreased 23.08 10.99 88 494885 6136 79243279
Infection reactivation 23.07 10.99 51 494922 2606 79246809
Gastritis erosive 23.05 10.99 20 494953 10827 79238588
Tension headache 22.99 10.99 8 494965 7203 79242212
Hepatic amoebiasis 22.98 10.99 12 494961 99 79249316
Diarrhoea haemorrhagic 22.95 10.99 29 494944 13205 79236210
Cartilage atrophy 22.95 10.99 14 494959 160 79249255
Blood chloride decreased 22.94 10.99 11 494962 8166 79241249
Large intestine polyp 22.94 10.99 27 494946 12681 79236734
Metastases to lung 22.91 10.99 49 494924 18114 79231301
Libido decreased 22.83 10.99 3 494970 5318 79244097
Rheumatoid lung 22.82 10.99 68 494905 4177 79245238
Neuroborreliosis 22.78 10.99 13 494960 130 79249285
Embolic stroke 22.77 10.99 10 494963 7816 79241599
Eosinophilic pneumonia 22.77 10.99 3 494970 5307 79244108
Granuloma 22.75 10.99 107 494866 8190 79241225
Forced expiratory volume decreased 22.71 10.99 10 494963 7804 79241611
Faecaloma 22.60 10.99 23 494950 11541 79237874
Human polyomavirus infection 22.60 10.99 31 494942 1075 79248340
Facial pain 22.55 10.99 26 494947 12324 79237091
Bundle branch block right 22.43 10.99 22 494951 11229 79238186
Muscle strain 22.35 10.99 16 494957 9539 79239876
Transplant rejection 22.25 10.99 201 494772 19236 79230179
Amylase increased 22.25 10.99 22 494951 11187 79238228
Breast cancer stage I 22.12 10.99 7 494966 6693 79242722
Toxic encephalopathy 22.08 10.99 23 494950 11417 79237998
Female genital tract fistula 22.07 10.99 5 494968 5970 79243445
Secretion discharge 22.05 10.99 37 494936 14985 79234430
Glomerular filtration rate decreased 21.94 10.99 70 494903 22632 79226783
Intestinal perforation 21.93 10.99 184 494789 17242 79232173
Enthesopathy 21.82 10.99 135 494838 11473 79237942
Bone marrow infiltration 21.79 10.99 25 494948 721 79248694
Anosmia 21.77 10.99 14 494959 8830 79240585
Muscle tightness 21.68 10.99 29 494944 12885 79236530
Hepatic cancer 21.67 10.99 20 494953 10509 79238906
Sleep apnoea syndrome 21.62 10.99 135 494838 36343 79213072
Chondropathy 21.57 10.99 48 494925 2464 79246951
Aplasia 21.55 10.99 101 494872 7719 79241696
Pneumonia pseudomonal 21.45 10.99 83 494890 5828 79243587
Femur fracture 21.41 10.99 146 494827 38506 79210909
Occult blood positive 21.32 10.99 8 494965 6875 79242540
Lupus vulgaris 21.32 10.99 57 494916 3289 79246126
Cardiac pacemaker insertion 21.25 10.99 5 494968 5817 79243598
Hypoxic-ischaemic encephalopathy 21.21 10.99 11 494962 7809 79241606
Cryoglobulinaemia 21.17 10.99 26 494947 807 79248608
Impaired driving ability 21.10 10.99 4 494969 5411 79244004
Neoplasm 21.06 10.99 112 494861 9004 79240411
Myelopathy 21.03 10.99 70 494903 4563 79244852
Coronary artery stenosis 20.99 10.99 28 494945 12456 79236959
International normalised ratio abnormal 20.96 10.99 5 494968 5763 79243652
Non-cardiac chest pain 20.93 10.99 17 494956 9507 79239908
Natural killer-cell leukaemia 20.74 10.99 11 494962 94 79249321
Cholestatic liver injury 20.70 10.99 3 494970 4938 79244477
Follicular lymphoma 20.70 10.99 18 494955 368 79249047
Diverticulum 20.67 10.99 38 494935 14858 79234557
Encephalopathy 20.66 10.99 294 494679 67103 79182312
Essential hypertension 20.57 10.99 6 494967 6047 79243368
Laryngitis 20.53 10.99 170 494803 15869 79233546
Meningitis enteroviral 20.52 10.99 10 494963 70 79249345
Cushingoid 20.48 10.99 115 494858 9437 79239978
Post cholecystectomy syndrome 20.46 10.99 18 494955 374 79249041
Dysphonia 20.42 10.99 240 494733 56632 79192783
Nodular regenerative hyperplasia 20.41 10.99 33 494940 1328 79248087
Neck mass 20.40 10.99 67 494906 4337 79245078
Status epilepticus 20.37 10.99 83 494890 24958 79224457
Rheumatic disorder 20.33 10.99 54 494919 3104 79246311
Immune thrombocytopenia 20.32 10.99 184 494789 17621 79231794
Rheumatoid factor 20.30 10.99 18 494955 378 79249037
Eosinophilic cystitis 20.26 10.99 11 494962 99 79249316
Hypercholesterolaemia 20.24 10.99 226 494747 22869 79226546
Polyuria 20.22 10.99 39 494934 14975 79234440
Gout 20.15 10.99 82 494891 24667 79224748
T-lymphocyte count decreased 20.03 10.99 21 494952 546 79248869
Peripheral venous disease 20.03 10.99 168 494805 15741 79233674
Alcohol poisoning 20.03 10.99 3 494970 4818 79244597
Vitreous floaters 19.99 10.99 10 494963 7246 79242169
Social avoidant behaviour 19.99 10.99 3 494970 4811 79244604
Craniocerebral injury 19.90 10.99 4 494969 5192 79244223
Central nervous system fungal infection 19.87 10.99 19 494954 441 79248974
Diplopia 19.76 10.99 124 494849 33342 79216073
Blood phosphorus increased 19.75 10.99 21 494952 10326 79239089
Concomitant disease aggravated 19.73 10.99 32 494941 13135 79236280
Blood immunoglobulin E increased 19.68 10.99 6 494967 5876 79243539
Peptic ulcer 19.67 10.99 7 494966 6216 79243199
Microscopic polyangiitis 19.65 10.99 18 494955 395 79249020
Norovirus infection 19.57 10.99 23 494950 681 79248734
Hepatitis cholestatic 19.53 10.99 35 494938 13817 79235598
Neuromyelitis optica spectrum disorder 19.50 10.99 28 494945 1014 79248401
Clonus 19.50 10.99 9 494964 6831 79242584
Fear of injection 19.49 10.99 95 494878 7379 79242036
Pseudomonal sepsis 19.47 10.99 83 494890 6091 79243324
Intervertebral disc space narrowing 19.44 10.99 37 494936 1698 79247717
Faeces soft 19.38 10.99 14 494959 8309 79241106
T-lymphocyte count increased 19.36 10.99 11 494962 109 79249306
Cardiac failure acute 19.27 10.99 57 494916 18872 79230543
Respiratory rate increased 19.22 10.99 212 494761 21388 79228027
Foetal exposure during pregnancy 19.20 10.99 6 494967 5784 79243631
Diaphragm muscle weakness 19.19 10.99 13 494960 180 79249235
Cestode infection 19.16 10.99 15 494958 263 79249152
Ventricular arrhythmia 19.15 10.99 16 494957 8824 79240591
Gynaecomastia 19.12 10.99 12 494961 7669 79241746
Antineutrophil cytoplasmic antibody increased 19.12 10.99 14 494959 221 79249194
Breast pain 19.12 10.99 14 494959 8251 79241164
Periostitis 19.08 10.99 22 494951 638 79248777
Joint effusion 18.98 10.99 183 494790 17831 79231584
Exercise tolerance decreased 18.95 10.99 17 494956 9054 79240361
Apnoea 18.93 10.99 27 494946 11677 79237738
Thrombotic microangiopathy 18.89 10.99 200 494773 19969 79229446
Lymphoproliferative disorder 18.89 10.99 77 494896 5538 79243877
Pain in jaw 18.87 10.99 189 494784 45962 79203453
Muscle spasticity 18.87 10.99 69 494904 21406 79228009
Aphasia 18.85 10.99 192 494781 46540 79202875
Plasma cell myeloma recurrent 18.85 10.99 4 494969 4997 79244418
Emotional disorder 18.84 10.99 38 494935 14349 79235066
Genitourinary tract infection 18.83 10.99 15 494958 270 79249145
Hypophosphataemia 18.83 10.99 62 494911 19851 79229564
Deep vein thrombosis 18.81 10.99 589 494384 120330 79129085
Nerve injury 18.78 10.99 111 494862 9281 79240134
Vulval ulceration 18.75 10.99 14 494959 228 79249187
Sensory disturbance 18.75 10.99 41 494932 15036 79234379
Blood glucose fluctuation 18.73 10.99 9 494964 6673 79242742
Refusal of treatment by patient 18.60 10.99 17 494956 8974 79240441
Splenic marginal zone lymphoma 18.59 10.99 9 494964 62 79249353
Leukaemia cutis 18.54 10.99 13 494960 191 79249224
Paraesthesia oral 18.50 10.99 65 494908 20406 79229009
Walking aid user 18.44 10.99 117 494856 10031 79239384
Larynx irritation 18.39 10.99 11 494962 121 79249294
Pneumonia klebsiella 18.37 10.99 71 494902 4983 79244432
Dermatitis bullous 18.33 10.99 38 494935 14207 79235208
Mucocutaneous haemorrhage 18.32 10.99 13 494960 195 79249220
Skin burning sensation 18.29 10.99 34 494939 13238 79236177
Glomerulonephritis rapidly progressive 18.28 10.99 35 494938 1613 79247802
Anal incontinence 18.28 10.99 55 494918 18113 79231302
Disorder of orbit 18.24 10.99 11 494962 123 79249292
Blood thyroid stimulating hormone increased 18.20 10.99 20 494953 9688 79239727
Skin plaque 18.17 10.99 24 494949 10721 79238694
Catheter site erythema 18.16 10.99 5 494968 5235 79244180
SARS-CoV-2 viraemia 18.15 10.99 8 494965 43 79249372
Stupor 18.15 10.99 10 494963 6862 79242553
Blood lactic acid increased 18.14 10.99 32 494941 12712 79236703
Cell-mediated immune deficiency 18.09 10.99 11 494962 125 79249290
Hypertensive crisis 18.07 10.99 67 494906 20703 79228712
Borrelia infection 18.00 10.99 14 494959 243 79249172
Productive cough 18.00 10.99 414 494559 87917 79161498
Fistula 17.97 10.99 33 494940 12907 79236508
Flank pain 17.94 10.99 63 494910 19781 79229634
Lupus nephritis 17.93 10.99 50 494923 2958 79246457
Angina pectoris 17.92 10.99 220 494753 51512 79197903
Nystagmus 17.92 10.99 21 494952 9883 79239532
Injection site hypersensitivity 17.92 10.99 38 494935 1887 79247528
Bilirubin conjugated increased 17.91 10.99 6 494967 5533 79243882
Intentional dose omission 17.85 10.99 17 494956 8800 79240615
Viral sepsis 17.85 10.99 12 494961 164 79249251
Psychomotor retardation 17.84 10.99 8 494965 6176 79243239
Meningitis tuberculous 17.78 10.99 29 494944 1176 79248239
Injection site discomfort 17.77 10.99 5 494968 5161 79244254
Rales 17.75 10.99 64 494909 19937 79229478
Crying 17.74 10.99 78 494895 22965 79226450
Arachnoiditis 17.61 10.99 23 494950 760 79248655
Atrioventricular block 17.61 10.99 38 494935 14003 79235412
Swollen joint count 17.60 10.99 29 494944 1186 79248229
Haemarthrosis 17.60 10.99 7 494966 5805 79243610
Enterovirus myocarditis 17.53 10.99 5 494968 4 79249411
N-terminal prohormone brain natriuretic peptide increased 17.52 10.99 4 494969 4751 79244664
Drug dependence 17.50 10.99 165 494808 40604 79208811
Neutrophil Pelger-Huet anomaly present 17.47 10.99 16 494957 351 79249064
Allergic oedema 17.43 10.99 23 494950 768 79248647
Citrobacter bacteraemia 17.39 10.99 6 494967 14 79249401
Acquired C1 inhibitor deficiency 17.39 10.99 6 494967 14 79249401
Product label confusion 17.39 10.99 34 494939 1592 79247823
Herpes simplex reactivation 17.39 10.99 18 494955 461 79248954
Refractory cytopenia with multilineage dysplasia 17.35 10.99 14 494959 257 79249158
Feeling drunk 17.33 10.99 4 494969 4715 79244700
Abnormal faeces 17.29 10.99 13 494960 7558 79241857
Incontinence 17.22 10.99 39 494934 14125 79235290
Blood phosphorus decreased 17.19 10.99 10 494963 6658 79242757
Infusion site erythema 17.18 10.99 20 494953 9440 79239975
Hypertonia 17.06 10.99 12 494961 7220 79242195
Electrocardiogram T wave inversion 17.05 10.99 6 494967 5366 79244049
Cryptococcosis 16.96 10.99 54 494919 3439 79245976
Abdominal lymphadenopathy 16.90 10.99 30 494943 1304 79248111
Neurological decompensation 16.86 10.99 71 494902 5182 79244233
Escherichia bacteraemia 16.82 10.99 83 494890 6479 79242936
Neoplasm recurrence 16.81 10.99 61 494912 4153 79245262
Scoliosis 16.81 10.99 13 494960 7451 79241964
Oxygen consumption increased 16.80 10.99 5 494968 4974 79244441
Gingival swelling 16.74 10.99 4 494969 4605 79244810
Device occlusion 16.71 10.99 30 494943 11836 79237579
Small intestinal obstruction 16.65 10.99 100 494873 27172 79222243
Hypoacusis 16.64 10.99 114 494859 30036 79219379
Procedural complication 16.63 10.99 15 494958 7968 79241447
Ischaemic cardiomyopathy 16.58 10.99 14 494959 7681 79241734
Abdominal tenderness 16.58 10.99 25 494948 10569 79238846
Post procedural haemorrhage 16.58 10.99 38 494935 13706 79235709
Pneumonia escherichia 16.57 10.99 24 494949 876 79248539
Passenger lymphocyte syndrome 16.56 10.99 10 494963 112 79249303
Leukaemic lymphoma 16.48 10.99 9 494964 82 79249333
Tongue pruritus 16.48 10.99 19 494954 551 79248864
Urine abnormality 16.46 10.99 16 494957 8203 79241212
Hypoalbuminaemia 16.45 10.99 72 494901 21225 79228190
Fluoride increased 16.39 10.99 9 494964 83 79249332
Hiccups 16.36 10.99 23 494950 10008 79239407
Vulvovaginal ulceration 16.35 10.99 4 494969 0 79249415
Acute flaccid myelitis 16.35 10.99 4 494969 0 79249415
Eosinophil count increased 16.35 10.99 53 494920 17052 79232363
Intraventricular haemorrhage 16.32 10.99 5 494968 4882 79244533
Overweight 16.31 10.99 3 494970 4147 79245268
Brain oedema 16.29 10.99 91 494882 25172 79224243
Renal tubular necrosis 16.25 10.99 90 494883 24949 79224466
Proctalgia 16.24 10.99 23 494950 9978 79239437
Red blood cell count decreased 16.21 10.99 255 494718 57258 79192157
Atrioventricular block complete 16.20 10.99 51 494922 16559 79232856
Pre-eclampsia 16.19 10.99 12 494961 7029 79242386
Asphyxia 16.18 10.99 30 494943 11690 79237725
Aspartate aminotransferase 16.13 10.99 19 494954 564 79248851
Peripheral ischaemia 16.12 10.99 21 494952 9436 79239979
Noninfectious myelitis 16.09 10.99 6 494967 19 79249396
Ocular icterus 16.05 10.99 7 494966 5493 79243922
Cytomegalovirus gastritis 16.03 10.99 17 494956 448 79248967
Infected seroma 16.03 10.99 9 494964 87 79249328
Prostatic abscess 16.03 10.99 16 494957 392 79249023
Escherichia sepsis 16.03 10.99 99 494874 8409 79241006
Cholecystectomy 16.02 10.99 21 494952 9411 79240004
Mucous stools 15.99 10.99 6 494967 5156 79244259
Smear cervix abnormal 15.95 10.99 43 494930 2493 79246922
Prescription drug used without a prescription 15.95 10.99 3 494970 4082 79245333
Haemorrhage subcutaneous 15.92 10.99 5 494968 4804 79244611
Inhibitory drug interaction 15.91 10.99 4 494969 4449 79244966
Cholesteatoma 15.91 10.99 10 494963 121 79249294
Low density lipoprotein increased 15.91 10.99 18 494955 8604 79240811
Paraesthesia ear 15.91 10.99 14 494959 291 79249124
Self-medication 15.84 10.99 6 494967 5126 79244289
Viral upper respiratory tract infection 15.75 10.99 103 494870 8923 79240492
Viral cardiomyopathy 15.68 10.99 7 494966 39 79249376
Wheezing 15.65 10.99 579 494394 116085 79133330
Petit mal epilepsy 15.62 10.99 8 494965 5719 79243696
Impaired gastric emptying 15.61 10.99 114 494859 10239 79239176
Retroperitoneal lymphadenopathy 15.59 10.99 26 494947 1074 79248341
Orthopnoea 15.55 10.99 24 494949 10049 79239366
Musculoskeletal chest pain 15.54 10.99 90 494883 24674 79224741
Intestinal atresia 15.53 10.99 8 494965 64 79249351
Proteus infection 15.48 10.99 38 494935 2080 79247335
Brain death 15.38 10.99 8 494965 5669 79243746
Sluggishness 15.38 10.99 11 494962 6561 79242854
Human rhinovirus test positive 15.33 10.99 17 494956 472 79248943
Wheelchair user 15.32 10.99 77 494896 6055 79243360
Candida pneumonia 15.31 10.99 20 494953 661 79248754
Herpes zoster infection neurological 15.27 10.99 13 494960 258 79249157
Exostosis 15.25 10.99 166 494807 16692 79232723
Bronchitis 15.23 10.99 659 494314 129985 79119430
Cardiomyopathy acute 15.21 10.99 14 494959 309 79249106
Jaw disorder 15.21 10.99 6 494967 5000 79244415
Spinal operation 15.19 10.99 16 494957 7901 79241514
Ecthyma 15.16 10.99 21 494952 735 79248680
Drooling 15.15 10.99 9 494964 5925 79243490
Granulocyte count increased 15.14 10.99 28 494945 1257 79248158
Primary immunodeficiency syndrome 15.12 10.99 8 494965 68 79249347
Peripheral T-cell lymphoma unspecified 15.11 10.99 20 494953 670 79248745
Heart rate abnormal 15.09 10.99 76 494897 5981 79243434
Cytomegalovirus oesophagitis 15.08 10.99 21 494952 739 79248676
Lacrimation increased 15.03 10.99 80 494893 22397 79227018
Helicobacter sepsis 15.02 10.99 6 494967 24 79249391
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 15.01 10.99 5 494968 10 79249405
Oesophageal pain 14.99 10.99 4 494969 4275 79245140
Tumour marker increased 14.95 10.99 4 494969 4268 79245147
Premenstrual syndrome 14.92 10.99 18 494955 548 79248867
Intermenstrual bleeding 14.92 10.99 9 494964 5875 79243540
Live birth 14.90 10.99 180 494793 18564 79230851
Abnormal loss of weight 14.90 10.99 18 494955 8358 79241057
Human herpesvirus 8 infection 14.90 10.99 27 494946 1193 79248222
Ureteric compression 14.78 10.99 13 494960 270 79249145
Posture abnormal 14.76 10.99 3 494970 3863 79245552
Combined immunodeficiency 14.74 10.99 9 494964 103 79249312
Germ cell cancer 14.74 10.99 11 494962 179 79249236
Lower gastrointestinal haemorrhage 14.71 10.99 51 494922 16074 79233341
Glottis carcinoma 14.69 10.99 5 494968 11 79249404
Biopsy bone marrow abnormal 14.66 10.99 17 494956 496 79248919
Capillaritis 14.62 10.99 13 494960 274 79249141
Ecchymosis 14.62 10.99 47 494926 15159 79234256
Ganglioneuroma 14.61 10.99 10 494963 141 79249274
B-lymphocyte count increased 14.61 10.99 10 494963 141 79249274
Peripheral vascular disorder 14.56 10.99 17 494956 8013 79241402
Splenic candidiasis 14.55 10.99 8 494965 74 79249341
Lymphadenitis viral 14.55 10.99 8 494965 74 79249341
Atypical femur fracture 14.53 10.99 7 494966 5182 79244233
Engraftment syndrome 14.51 10.99 29 494944 1380 79248035
Product preparation error 14.49 10.99 9 494964 5784 79243631
Infective exacerbation of chronic obstructive airways disease 14.40 10.99 44 494929 2740 79246675
Klebsiella infection 14.31 10.99 155 494818 15565 79233850
Polyneuropathy 14.31 10.99 220 494753 23931 79225484
Duodenal ulcer haemorrhage 14.28 10.99 14 494959 7149 79242266
Pharyngitis streptococcal 14.28 10.99 28 494945 10686 79238729
Limb mass 14.28 10.99 52 494921 3547 79245868
Overlap syndrome 14.24 10.99 24 494949 1000 79248415
Calciphylaxis 14.24 10.99 3 494970 3767 79245648
Proteinuria 14.20 10.99 282 494691 32220 79217195
Product dispensing error 14.19 10.99 39 494934 13224 79236191
Atrial tachycardia 14.16 10.99 14 494959 7119 79242296
Intraocular pressure increased 14.14 10.99 22 494951 9183 79240232
Interchange of vaccine products 14.13 10.99 4 494969 3 79249412
Bing-Neel syndrome 14.13 10.99 4 494969 3 79249412
B-cell small lymphocytic lymphoma recurrent 14.12 10.99 5 494968 13 79249402
Nasal cavity cancer 14.10 10.99 12 494961 238 79249177
Muscle disorder 14.09 10.99 9 494964 5698 79243717
Tongue oedema 14.09 10.99 14 494959 7103 79242312
CD8 lymphocytes increased 14.02 10.99 7 494966 52 79249363
Metastases to lymph nodes 14.01 10.99 27 494946 10370 79239045
Gallbladder disorder 13.97 10.99 67 494906 19273 79230142
Bacille Calmette-Guerin scar reactivation 13.97 10.99 6 494967 30 79249385
Premature labour 13.92 10.99 19 494954 8371 79241044
Vascular stent thrombosis 13.91 10.99 3 494970 3707 79245708
Wrist surgery 13.91 10.99 21 494952 796 79248619
Device adhesion issue 13.91 10.99 14 494959 7061 79242354
Pneumonia respiratory syncytial viral 13.91 10.99 34 494939 1856 79247559
Lacunar infarction 13.90 10.99 10 494963 5947 79243468
Premature delivery 13.83 10.99 87 494886 23380 79226035
Diabetic neuropathy 13.78 10.99 11 494962 6205 79243210
B-lymphocyte count abnormal 13.77 10.99 8 494965 83 79249332
Acute biphenotypic leukaemia 13.76 10.99 10 494963 156 79249259
Joint ankylosis 13.75 10.99 37 494936 2143 79247272
Renal tubular disorder 13.73 10.99 12 494961 6474 79242941
Lupus-like syndrome 13.73 10.99 139 494834 13718 79235697
Amyotrophic lateral sclerosis 13.73 10.99 33 494940 1782 79247633
Glucose tolerance impaired 13.73 10.99 18 494955 8066 79241349
Rhonchi 13.71 10.99 4 494969 4032 79245383
Internal haemorrhage 13.68 10.99 21 494952 8812 79240603
Wound secretion 13.66 10.99 11 494962 6177 79243238
Blood immunoglobulin A increased 13.62 10.99 23 494950 960 79248455
Clear cell renal cell carcinoma 13.60 10.99 41 494932 2535 79246880
Noninfective encephalitis 13.60 10.99 18 494955 603 79248812
Anaemia macrocytic 13.59 10.99 9 494964 5588 79243827
Anti-glomerular basement membrane disease 13.59 10.99 7 494966 56 79249359
Lung diffusion test decreased 13.54 10.99 27 494946 1283 79248132
Self-injurious ideation 13.53 10.99 3 494970 3635 79245780
Lip pruritus 13.53 10.99 22 494951 890 79248525
Panic reaction 13.51 10.99 6 494967 4659 79244756
Knee operation 13.49 10.99 10 494963 5856 79243559
Cardiac tamponade 13.47 10.99 23 494950 9253 79240162
Snoring 13.44 10.99 9 494964 5557 79243858
Red blood cells urine positive 13.43 10.99 7 494966 4956 79244459
Skin laceration 13.40 10.99 115 494858 28847 79220568
Pulmonary mass 13.39 10.99 254 494719 28780 79220635
Skin lesion 13.37 10.99 181 494792 41663 79207752
Gastrointestinal motility disorder 13.36 10.99 11 494962 6111 79243304
Skin abrasion 13.35 10.99 41 494932 13415 79236000
Central nervous system vasculitis 13.34 10.99 28 494945 1380 79248035
CD8 lymphocytes decreased 13.34 10.99 12 494961 257 79249158
Laryngeal pain 13.33 10.99 11 494962 6103 79243312
Chylothorax 13.31 10.99 20 494953 755 79248660
Adenocarcinoma gastric 13.31 10.99 32 494941 1729 79247686
Haemodynamic instability 13.28 10.99 59 494914 17323 79232092
Systemic candida 13.25 10.99 79 494894 6627 79242788
Anal fissure 13.23 10.99 17 494956 7686 79241729
Sinus node dysfunction 13.23 10.99 17 494956 7684 79241731
Localised oedema 13.20 10.99 18 494955 7934 79241481
Amenorrhoea 13.19 10.99 17 494956 7675 79241740
Ataxia 13.17 10.99 96 494877 24943 79224472
Ovarian hyperstimulation syndrome 13.17 10.99 3 494970 3568 79245847
Cardiac murmur 13.15 10.99 52 494921 15772 79233643
Allergy to vaccine 13.14 10.99 11 494962 213 79249202
Spirochaetal infection 13.14 10.99 5 494968 17 79249398
Positron emission tomogram abnormal 13.11 10.99 14 494959 372 79249043
Autoimmune hepatitis 13.10 10.99 34 494939 11749 79237666
Metastases to spleen 13.08 10.99 18 494955 626 79248789
Plasma cells decreased 13.08 10.99 6 494967 36 79249379
Blood bicarbonate decreased 13.08 10.99 8 494965 5183 79244232
Mouth swelling 13.05 10.99 11 494962 6040 79243375
Electrocardiogram ST segment depression 13.03 10.99 7 494966 4871 79244544
Pancreatic carcinoma 13.03 10.99 42 494931 13535 79235880
Nephrogenic anaemia 13.02 10.99 4 494969 3898 79245517
Lip oedema 13.00 10.99 12 494961 6304 79243111
Diastolic dysfunction 12.95 10.99 30 494943 10781 79238634
Foot operation 12.95 10.99 70 494903 5663 79243752
Liver function test increased 12.95 10.99 331 494642 39442 79209973
Leukoencephalopathy 12.94 10.99 89 494884 7840 79241575
Multiple system atrophy 12.93 10.99 14 494959 378 79249037
Therapy responder 12.93 10.99 15 494958 438 79248977
Lung infiltration 12.92 10.99 207 494766 22705 79226710
Device use error 12.91 10.99 15 494958 7086 79242329
Bladder transitional cell carcinoma 12.90 10.99 41 494932 2609 79246806
Affect lability 12.89 10.99 32 494941 11227 79238188
Pneumothorax 12.86 10.99 113 494860 28210 79221205
Blood thyroid stimulating hormone decreased 12.82 10.99 10 494963 5706 79243709
Cellulitis gangrenous 12.82 10.99 12 494961 271 79249144
Cold sweat 12.81 10.99 66 494907 18633 79230782
Relapsing multiple sclerosis 12.79 10.99 9 494964 133 79249282
Renal disorder 12.79 10.99 184 494789 41921 79207494
Catheter site infection 12.74 10.99 14 494959 6781 79242634
White blood cell count increased 12.74 10.99 359 494614 74274 79175141
Catheter site haemorrhage 12.73 10.99 8 494965 5109 79244306
Follicle centre lymphoma, follicular grade I, II, III recurrent 12.73 10.99 4 494969 6 79249409
Feeling hot 12.73 10.99 278 494695 59456 79189959
Prolymphocytic leukaemia 12.73 10.99 4 494969 6 79249409
Red cell fragmentation syndrome 12.71 10.99 7 494966 65 79249350
Aortic dissection 12.69 10.99 5 494968 4170 79245245
Pericardial haemorrhage 12.68 10.99 6 494967 4489 79244926
Cat scratch disease 12.67 10.99 14 494959 387 79249028
Blood sodium increased 12.65 10.99 7 494966 4791 79244624
Ocular lymphoma 12.64 10.99 8 494965 98 79249317
Psychiatric symptom 12.64 10.99 15 494958 7020 79242395
Graft versus host disease in gastrointestinal tract 12.63 10.99 75 494898 6281 79243134
Stem cell transplant 12.63 10.99 51 494922 3653 79245762
Central nervous system infection 12.60 10.99 27 494946 1350 79248065
International normalised ratio fluctuation 12.54 10.99 3 494970 3451 79245964
Femoral neck fracture 12.54 10.99 27 494946 9957 79239458
Vitamin B12 increased 12.53 10.99 25 494948 1188 79248227
Device breakage 12.49 10.99 30 494943 10645 79238770
Superior mesenteric artery syndrome 12.46 10.99 10 494963 182 79249233
Frustration tolerance decreased 12.44 10.99 17 494956 7485 79241930
Transient hypogammaglobulinaemia of infancy 12.43 10.99 6 494967 41 79249374
Arteriospasm coronary 12.41 10.99 14 494959 6702 79242713
Troponin I increased 12.36 10.99 7 494966 4731 79244684
Disseminated cytomegaloviral infection 12.35 10.99 15 494958 460 79248955
Myasthenia gravis 12.35 10.99 29 494944 10370 79239045
Abdominal neoplasm 12.34 10.99 17 494956 592 79248823
Drug use disorder 12.33 10.99 94 494879 8557 79240858
Liver transplant 12.33 10.99 6 494967 4417 79244998
Gastric pneumatosis 12.33 10.99 5 494968 21 79249394
Chest wall tumour 12.31 10.99 6 494967 42 79249373
Diabetes mellitus inadequate control 12.30 10.99 94 494879 24170 79225245
CD4 lymphocytes increased 12.29 10.99 12 494961 286 79249129
Pruritus 12.28 10.99 2209 492764 392439 78856976
Intestinal resection 12.27 10.99 4 494969 3753 79245662
Extranodal marginal zone B-cell lymphoma (MALT type) recurrent 12.27 10.99 3 494970 0 79249415
Communication disorder 12.26 10.99 5 494968 4085 79245330
Sacroiliitis 12.25 10.99 4 494969 3750 79245665
Pancreatic carcinoma metastatic 12.25 10.99 4 494969 3749 79245666
Hypopituitarism 12.25 10.99 3 494970 3396 79246019
Myelitis transverse 12.24 10.99 33 494940 1914 79247501
Rash maculo-papular 12.23 10.99 260 494713 55818 79193597
Arthritis reactive 12.23 10.99 17 494956 597 79248818
Mucocutaneous leishmaniasis 12.23 10.99 15 494958 465 79248950
Myeloproliferative neoplasm 12.22 10.99 22 494951 967 79248448
Retroperitoneal haematoma 12.22 10.99 9 494964 5288 79244127
Gastric polyps 12.22 10.99 4 494969 3743 79245672
Neutrophilia 12.22 10.99 19 494954 7932 79241483
Procedural haemorrhage 12.21 10.99 7 494966 4699 79244716
Metabolic disorder 12.19 10.99 24 494949 9146 79240269
Injection site inflammation 12.19 10.99 53 494920 3923 79245492
Aortic arteriosclerosis 12.16 10.99 23 494950 8895 79240520
Lichen sclerosus 12.14 10.99 22 494951 972 79248443
Chronic myeloid leukaemia 12.13 10.99 50 494923 3614 79245801
Blood glucose abnormal 12.12 10.99 30 494943 10536 79238879
Anal prolapse 12.10 10.99 7 494966 72 79249343
Restless legs syndrome 12.09 10.99 74 494899 20018 79229397
Primary amyloidosis 12.09 10.99 9 494964 146 79249269
Osteonecrosis 12.04 10.99 129 494844 30966 79218449
Opportunistic infection 12.02 10.99 43 494930 2907 79246508
Non-Hodgkin's lymphoma recurrent 11.97 10.99 5 494968 23 79249392
Anorectal varices 11.97 10.99 6 494967 45 79249370
Hepatic necrosis 11.94 10.99 24 494949 9076 79240339
Laryngeal stenosis 11.94 10.99 23 494950 1065 79248350
Gastroenteritis clostridial 11.93 10.99 21 494952 907 79248508
Peritonitis bacterial 11.91 10.99 26 494947 9541 79239874
Dysphagia 11.88 10.99 628 494345 121508 79127907
Superinfection bacterial 11.85 10.99 28 494945 1496 79247919
Movement disorder 11.84 10.99 110 494863 27149 79222266
Disseminated strongyloidiasis 11.84 10.99 11 494962 246 79249169
Failure to thrive 11.81 10.99 36 494937 11808 79237607
Cyst 11.81 10.99 45 494928 13795 79235620
Atypical fibroxanthoma 11.80 10.99 10 494963 197 79249218
Nasal discomfort 11.79 10.99 10 494963 5473 79243942
Thyroiditis 11.74 10.99 7 494966 4598 79244817
Granulocyte count decreased 11.72 10.99 31 494942 1777 79247638
Soft tissue sarcoma 11.72 10.99 10 494963 199 79249216
Carpal tunnel syndrome 11.71 10.99 72 494901 19456 79229959
Primary mediastinal large B-cell lymphoma recurrent 11.70 10.99 7 494966 77 79249338
Urine odour abnormal 11.68 10.99 13 494960 6260 79243155
Central nervous system lupus 11.67 10.99 15 494958 488 79248927
Energy increased 11.63 10.99 3 494970 3279 79246136
Heart rate increased 11.62 10.99 885 494088 119839 79129576
Cranial nerve disorder 11.62 10.99 23 494950 1087 79248328
Drug eruption 11.60 10.99 356 494617 43579 79205836
Evans syndrome 11.59 10.99 14 494959 427 79248988
Electroencephalogram abnormal 11.57 10.99 10 494963 5424 79243991
Mood swings 11.56 10.99 74 494899 19806 79229609
Schistocytosis 11.54 10.99 6 494967 49 79249366
Lung adenocarcinoma 11.52 10.99 86 494887 7778 79241637
Body temperature decreased 11.51 10.99 271 494702 31874 79217541
Malnutrition 11.49 10.99 87 494886 22415 79227000
Jaundice cholestatic 11.47 10.99 34 494939 11250 79238165
Acute myelomonocytic leukaemia 11.45 10.99 12 494961 312 79249103
Hair colour changes 11.41 10.99 6 494967 4226 79245189
Suspected COVID-19 11.37 10.99 44 494929 3089 79246326
Skin induration 11.36 10.99 7 494966 4518 79244897
Dysplasia 11.36 10.99 26 494947 1360 79248055
Febrile infection 11.35 10.99 46 494927 3300 79246115
Duodenitis 11.35 10.99 20 494953 7947 79241468
Cytokine storm 11.34 10.99 22 494951 1024 79248391
Chronic hepatitis B 11.34 10.99 14 494959 437 79248978
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.30 10.99 3 494970 3218 79246197
Pustular psoriasis 11.30 10.99 8 494965 4798 79244617
Lower respiratory tract congestion 11.29 10.99 52 494921 3945 79245470
Pupil fixed 11.29 10.99 4 494969 3562 79245853
Gastrointestinal pain 11.29 10.99 28 494945 9827 79239588
Facial bones fracture 11.26 10.99 9 494964 5073 79244342
Adverse drug reaction 11.25 10.99 512 494461 65880 79183535
Tachypnoea 11.24 10.99 136 494837 31927 79217488
Spinal stenosis 11.24 10.99 55 494918 15736 79233679
Hepatitis B surface antibody positive 11.24 10.99 11 494962 263 79249152
Sensitivity to weather change 11.23 10.99 87 494886 7960 79241455
Nail pigmentation 11.20 10.99 12 494961 320 79249095
Paradoxical drug reaction 11.20 10.99 17 494956 7168 79242247
Hepatitis B DNA increased 11.20 10.99 19 494954 796 79248619
B-lymphocyte abnormalities 11.18 10.99 5 494968 28 79249387
Cheilitis 11.17 10.99 10 494963 5331 79244084
Neoplasm progression 11.16 10.99 409 494564 51273 79198142
Photopsia 11.15 10.99 10 494963 5326 79244089
Skin disorder 11.14 10.99 146 494827 33797 79215618
Hereditary angioedema 11.14 10.99 10 494963 5325 79244090
Food poisoning 11.14 10.99 8 494965 4761 79244654
Extranodal marginal zone B-cell lymphoma (MALT type) 11.13 10.99 16 494957 580 79248835
Oral pain 11.10 10.99 135 494838 31663 79217752
Sleep disorder 11.10 10.99 644 494329 85033 79164382
Metastases to bone marrow 11.08 10.99 19 494954 803 79248612
Hypovolaemic shock 11.08 10.99 39 494934 12237 79237178
Aspergillosis oral 11.05 10.99 6 494967 54 79249361
Dental restoration failure 11.04 10.99 21 494952 963 79248452
Graft versus host disease in skin 11.02 10.99 70 494903 6003 79243412
Focal dyscognitive seizures 11.02 10.99 4 494969 3508 79245907
Adverse reaction 11.01 10.99 97 494876 9217 79240198

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
CD20 (Clusters of Differentiation 20) inhibitors
FDA MoA N0000175078 CD20-directed Antibody Interactions
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
FDA EPC N0000175657 CD20-directed Cytolytic Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Burkitt cell leukemia indication 22197008
Neuromyelitis optica indication 25044007 DOID:8869
Pemphigus foliaceus indication 35154004
Pemphigus vulgaris indication 49420001 DOID:0060851
Follicular lymphoma indication 55150002
Rheumatoid arthritis indication 69896004 DOID:7148
Burkitt's lymphoma indication 77381001 DOID:8584
Thrombotic thrombocytopenic purpura indication 78129009 DOID:10772
Systemic sclerosis indication 89155008 DOID:418
Chronic lymphoid leukemia, disease indication 92814006
CD20 positive diffuse large B cell non Hodgkin's lymphoma indication 109969005
Non-Hodgkin's lymphoma indication 118601006
Granulomatosis with polyangiitis indication 195353004 DOID:12132
Microscopic polyarteritis nodosa indication 239928004
Microscopic polyangiitis indication 1144805008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
B-lymphocyte antigen CD20 Surface antigen ANTIBODY BINDING Kd 8.51 IUPHAR DRUG LABEL

External reference:

IDSource
D02994 KEGG_DRUG
4021104 VUID
N0000148560 NUI
4021104 VANDF
CHEMBL1201576 ChEMBL_ID
6780 IUPHAR_LIGAND_ID
DB00073 DRUGBANK_ID
121191 RXNORM
11468 MMSL
5432 MMSL
d04255 MMSL
007236 NDDF
108809004 SNOMEDCT_US
386919002 SNOMEDCT_US
D000069283 MESH_DESCRIPTOR_UI
C0393022 UMLSCUI
7609 INN_ID
4F4X42SYQ6 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0238 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0249 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 30 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-108 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-108 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-109 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-109 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-224 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-224 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-326 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-326 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 32 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-103 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-103 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-103 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-104 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-104 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-104 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections