rituximab Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4975 174722-31-7

Description:

MoleculeDescription

Synonyms:

  • rituximab
  • rituxan
  • MabThera
A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 25, 2008 PMDA Bayer Yakuhin, Nihon Schering, Zenyaku Kogyo
Nov. 26, 1997 FDA GENENTECH
June 2, 1998 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 4710.87 11.15 6008 237461 234207 46208386
Drug ineffective 3435.70 11.15 9435 234034 668403 45774190
Contraindicated product administered 2355.28 11.15 2473 240996 77474 46365119
Drug intolerance 1953.74 11.15 3061 240408 143988 46298605
Treatment failure 1931.78 11.15 2402 241067 90685 46351908
Infusion related reaction 1562.39 11.15 2261 241208 98947 46343646
Joint swelling 1237.30 11.15 2695 240774 163378 46279215
Pemphigus 1205.95 11.15 1329 242140 43945 46398648
Intentional product use issue 1168.10 11.15 1408 242061 51372 46391221
Off label use 1098.86 11.15 4393 239076 375448 46067145
Progressive multifocal leukoencephalopathy 1018.37 11.15 671 242798 10675 46431918
Systemic lupus erythematosus 1017.76 11.15 1465 242004 63715 46378878
Synovitis 927.64 11.15 1355 242114 59720 46382873
Therapeutic product effect decreased 795.86 11.15 1493 241976 81108 46361485
Hand deformity 731.57 11.15 902 242567 33672 46408921
Completed suicide 722.33 11.15 7 243462 145913 46296680
Glossodynia 684.50 11.15 992 242477 43381 46399212
Arthropathy 625.34 11.15 1371 242098 83329 46359264
Hypogammaglobulinaemia 578.32 11.15 358 243111 5080 46437513
Product dose omission issue 558.41 11.15 102 243367 168418 46274175
Rheumatoid factor positive 551.99 11.15 605 242864 19856 46422737
Alopecia 542.47 11.15 1970 241499 160444 46282149
Febrile neutropenia 537.33 11.15 1383 242086 93244 46349349
Abdominal discomfort 529.94 11.15 1863 241606 149302 46293291
Infection 517.94 11.15 1703 241766 131889 46310704
Drug interaction 490.14 11.15 223 243246 202871 46239722
Anti-cyclic citrullinated peptide antibody positive 463.33 11.15 535 242934 18610 46423983
Toxicity to various agents 406.95 11.15 306 243163 211460 46231133
Diffuse large B-cell lymphoma recurrent 396.42 11.15 181 243288 1311 46441282
Product use in unapproved indication 386.29 11.15 1191 242278 89082 46353511
Swelling 385.93 11.15 1475 241994 123036 46319557
Dizziness 383.82 11.15 747 242722 339667 46102926
Hepatic enzyme increased 378.19 11.15 1109 242360 80678 46361915
Red blood cell sedimentation rate increased 369.37 11.15 523 242946 22366 46420227
Loss of personal independence in daily activities 366.85 11.15 876 242593 56307 46386286
Musculoskeletal stiffness 365.98 11.15 1234 242235 96759 46345834
Overdose 361.73 11.15 51 243418 101928 46340665
Injection site pain 356.62 11.15 64 243405 107088 46335505
Fall 337.42 11.15 762 242707 328335 46114258
Neutropenia 323.37 11.15 1541 241928 141663 46300930
Intentional overdose 321.74 11.15 3 243466 64941 46377652
Anxiety 314.84 11.15 291 243178 181666 46260927
Drug abuse 313.79 11.15 3 243466 63405 46379188
Arthralgia 303.57 11.15 3067 240402 361536 46081057
C-reactive protein increased 289.68 11.15 814 242655 57776 46384817
Pain 277.72 11.15 3744 239725 473204 45969389
Feeling abnormal 263.67 11.15 163 243306 124897 46317696
Vomiting 256.39 11.15 1354 242115 451440 45991153
Wound 253.50 11.15 636 242833 42166 46400427
Diffuse large B-cell lymphoma 252.26 11.15 225 243244 5713 46436880
Bone erosion 250.79 11.15 277 243192 9166 46433427
C-reactive protein abnormal 246.33 11.15 417 243052 20853 46421740
Acute kidney injury 237.47 11.15 551 242918 235304 46207289
Drug hypersensitivity 236.22 11.15 2119 241350 241706 46200887
Therapeutic product effect incomplete 230.64 11.15 912 242557 77241 46365352
Cardiac failure congestive 225.38 11.15 98 243371 91652 46350941
Confusional state 220.66 11.15 307 243162 159585 46283008
Hypersensitivity 220.45 11.15 1440 242029 148881 46293712
Diarrhoea 216.09 11.15 1875 241594 557727 45884866
Product use issue 213.10 11.15 1018 242451 93626 46348967
Pericarditis 207.47 11.15 414 243055 23513 46419080
Oedema peripheral 206.36 11.15 321 243148 159385 46283208
Muscle spasms 202.25 11.15 206 243263 122907 46319686
Hepatitis B 200.17 11.15 161 243308 3532 46439061
Constipation 196.65 11.15 381 243088 173716 46268877
Dehydration 193.68 11.15 334 243135 159206 46283387
Panniculitis 192.12 11.15 190 243279 5514 46437079
Suicide attempt 191.68 11.15 29 243440 55007 46387586
Dyspnoea 187.24 11.15 1754 241715 513794 45928799
B-lymphocyte count decreased 186.49 11.15 89 243380 721 46441872
Ill-defined disorder 181.77 11.15 420 243049 26407 46416186
Hyponatraemia 179.97 11.15 158 243311 101174 46341419
Rheumatoid nodule 177.40 11.15 227 243242 8793 46433800
Throat irritation 176.95 11.15 435 243034 28466 46414127
Herpes zoster 175.82 11.15 761 242708 67111 46375482
Granuloma skin 174.88 11.15 145 243324 3325 46439268
Inflammation 174.65 11.15 606 242863 48175 46394418
Serum sickness 173.89 11.15 126 243343 2352 46440241
Pneumocystis jirovecii pneumonia 172.67 11.15 296 243173 14952 46427641
Rhabdomyolysis 171.82 11.15 12 243457 41897 46400696
Blood parathyroid hormone decreased 170.42 11.15 158 243311 4223 46438370
Wrong technique in product usage process 169.53 11.15 38 243431 54384 46388209
Post transplant lymphoproliferative disorder 165.56 11.15 147 243322 3709 46438884
Decreased appetite 165.14 11.15 492 242977 193344 46249249
Hospitalisation 164.94 11.15 62 243407 63323 46379270
Tremor 163.55 11.15 218 243251 115421 46327172
Injection site erythema 162.44 11.15 93 243376 74334 46368259
Cytomegalovirus infection 162.19 11.15 318 243151 17826 46424767
Hip arthroplasty 158.96 11.15 315 243154 17797 46424796
Pulmonary fibrosis 158.09 11.15 334 243135 19758 46422835
Blood pressure fluctuation 156.32 11.15 429 243040 30019 46412574
Myelodysplastic syndrome 156.05 11.15 288 243181 15423 46427170
International normalised ratio increased 155.92 11.15 28 243441 46855 46395738
Suicidal ideation 155.57 11.15 50 243419 56332 46386261
Diffuse large B-cell lymphoma refractory 154.77 11.15 83 243386 881 46441712
Inappropriate schedule of product administration 154.09 11.15 73 243396 64940 46377653
Rash 153.28 11.15 2660 240809 353852 46088741
Blood pressure diastolic abnormal 152.43 11.15 176 243293 6118 46436475
Hypoglycaemia 146.80 11.15 50 243419 54299 46388294
Electrocardiogram QT prolonged 144.32 11.15 44 243425 51281 46391312
Seizure 143.53 11.15 264 243205 122790 46319803
Bradycardia 143.04 11.15 84 243385 66214 46376379
Incorrect dose administered 141.48 11.15 32 243437 45518 46397075
Plasma cell myeloma 140.68 11.15 30 243439 44448 46398145
Myalgia 140.11 11.15 268 243201 122820 46319773
Therapeutic response decreased 138.29 11.15 517 242952 42628 46399965
Hyperkalaemia 138.09 11.15 46 243423 50663 46391930
Depressed level of consciousness 137.01 11.15 39 243430 47530 46395063
Intentional product misuse 136.92 11.15 38 243431 47090 46395503
Blood pressure systolic abnormal 136.52 11.15 156 243313 5361 46437232
Joint stiffness 136.24 11.15 379 243090 26729 46415864
Tumour lysis syndrome 135.89 11.15 178 243291 7058 46435535
Cardio-respiratory arrest 134.71 11.15 72 243397 59797 46382796
Musculoskeletal deformity 134.50 11.15 71 243398 728 46441865
Demyelination 134.49 11.15 157 243312 5523 46437070
No adverse event 131.99 11.15 436 243033 33795 46408798
Cardiac arrest 131.31 11.15 167 243302 90232 46352361
Somnolence 129.89 11.15 402 243067 156119 46286474
B-cell lymphoma recurrent 129.42 11.15 57 243412 375 46442218
Vision blurred 129.02 11.15 135 243334 79573 46363020
Product quality issue 128.30 11.15 17 243452 35631 46406962
Maternal exposure during pregnancy 127.56 11.15 944 242525 101605 46340988
JC virus infection 126.97 11.15 89 243380 1573 46441020
Foot deformity 126.70 11.15 261 243208 15164 46427429
Injection site pruritus 125.30 11.15 27 243442 39716 46402877
Chronic lymphocytic leukaemia 123.41 11.15 110 243359 2790 46439803
Skin necrosis 123.40 11.15 186 243283 8418 46434175
Breast cancer stage III 122.89 11.15 81 243388 1288 46441305
Agitation 122.70 11.15 68 243401 55347 46387246
Gastrooesophageal reflux disease 122.49 11.15 124 243345 74220 46368373
Arthritis 121.42 11.15 754 242715 76562 46366031
Coeliac disease 120.51 11.15 167 243302 6994 46435599
Multiple sclerosis relapse 120.46 11.15 35 243434 42090 46400503
Drug tolerance decreased 118.36 11.15 110 243359 2949 46439644
Injection site swelling 116.25 11.15 33 243436 40294 46402299
Sciatica 115.07 11.15 285 243184 18735 46423858
Contrast media allergy 113.93 11.15 86 243383 1713 46440880
Hallucination 112.48 11.15 60 243409 49891 46392702
Ear pruritus 111.89 11.15 91 243378 2029 46440564
Helicobacter infection 111.39 11.15 211 243258 11525 46431068
Elbow deformity 111.25 11.15 76 243393 1286 46441307
Abdominal pain 110.49 11.15 724 242745 229307 46213286
Knee arthroplasty 110.30 11.15 322 243147 23343 46419250
Insomnia 110.05 11.15 464 243005 164460 46278133
Death 109.60 11.15 1170 242299 334378 46108215
Respiratory arrest 108.61 11.15 22 243447 33794 46408799
Anaphylactic reaction 108.57 11.15 556 242913 52556 46390037
Sleep disorder 107.89 11.15 507 242962 46288 46396305
Disease recurrence 107.78 11.15 273 243196 18198 46424395
B-cell lymphoma 107.75 11.15 108 243361 3186 46439407
Secondary immunodeficiency 107.53 11.15 66 243403 921 46441672
Gastrointestinal haemorrhage 107.20 11.15 148 243321 77225 46365368
Emotional distress 105.05 11.15 17 243452 30690 46411903
Lactic acidosis 104.95 11.15 24 243445 33885 46408708
Disability 104.29 11.15 189 243280 9978 46432615
Grip strength decreased 103.99 11.15 172 243297 8434 46434159
Cerebrovascular accident 103.15 11.15 234 243235 100805 46341788
Granulomatosis with polyangiitis 102.88 11.15 81 243388 1721 46440872
Asthma 102.68 11.15 201 243268 91341 46351252
Nausea 102.25 11.15 2769 240700 684685 45757908
Chronic lymphocytic leukaemia recurrent 102.16 11.15 39 243430 167 46442426
Memory impairment 102.14 11.15 153 243316 77184 46365409
Staphylococcal bacteraemia 102.13 11.15 127 243342 4777 46437816
Basal cell carcinoma 101.54 11.15 285 243184 20202 46422391
Metabolic acidosis 100.76 11.15 38 243431 38742 46403851
SLE arthritis 100.71 11.15 54 243415 573 46442020
White blood cell count abnormal 100.67 11.15 129 243340 5003 46437590
Immunodeficiency 99.79 11.15 215 243254 12891 46429702
Neuromyelitis optica spectrum disorder 99.59 11.15 59 243410 769 46441824
Epstein-Barr virus infection 99.21 11.15 148 243321 6636 46435957
Unresponsive to stimuli 99.13 11.15 23 243446 32151 46410442
Dyskinesia 98.98 11.15 16 243453 28909 46413684
Bone marrow failure 98.82 11.15 360 243109 29309 46413284
Swelling face 98.76 11.15 79 243390 52980 46389613
Myocardial infarction 98.65 11.15 227 243242 97301 46345292
Malaise 97.55 11.15 1182 242287 330050 46112543
Asthenia 97.03 11.15 1096 242373 309979 46132614
Agranulocytosis 96.89 11.15 295 243174 21890 46420703
Red blood cell sedimentation rate abnormal 95.00 11.15 216 243253 13433 46429160
Abdominal pain upper 94.35 11.15 413 243056 144892 46297701
Leukopenia 94.18 11.15 645 242824 67698 46374895
Liver function test increased 93.65 11.15 297 243172 22529 46420064
Blood glucose increased 93.63 11.15 144 243325 71869 46370724
Lethargy 92.99 11.15 78 243391 51093 46391500
Discomfort 92.91 11.15 485 242984 46185 46396408
Headache 92.42 11.15 1850 241619 476502 45966091
Hepatitis B reactivation 90.66 11.15 70 243399 1444 46441149
Dysgeusia 90.64 11.15 49 243420 40442 46402151
Therapy non-responder 90.62 11.15 440 243029 40712 46401881
Bronchitis chronic 90.14 11.15 110 243359 4057 46438536
Disorientation 89.72 11.15 40 243429 36878 46405715
Blood immunoglobulin M decreased 89.03 11.15 52 243417 659 46441934
Therapy cessation 88.33 11.15 16 243453 26613 46415980
Paraesthesia 88.18 11.15 315 243154 117122 46325471
Product prescribing error 87.51 11.15 4 243465 20043 46422550
Ulcer 87.23 11.15 243 243226 17149 46425444
Device issue 87.18 11.15 4 243465 19976 46422617
Obliterative bronchiolitis 87.02 11.15 73 243396 1702 46440891
Duodenal ulcer perforation 85.88 11.15 157 243312 8345 46434248
Spinal column injury 85.67 11.15 73 243396 1740 46440853
Therapy partial responder 84.56 11.15 113 243356 4569 46438024
Migraine 84.52 11.15 147 243322 69879 46372714
Haematochezia 84.47 11.15 45 243424 37448 46405145
Physical disability 84.05 11.15 73 243396 1787 46440806
Hypokalaemia 83.39 11.15 212 243257 87812 46354781
Surgical failure 81.31 11.15 55 243414 915 46441678
Coma 80.43 11.15 112 243357 58237 46384356
Chest pain 78.16 11.15 568 242901 175756 46266837
Onychomycosis 77.92 11.15 102 243367 4041 46438552
Sopor 77.57 11.15 7 243462 19821 46422772
Irritability 77.52 11.15 27 243442 28919 46413674
Condition aggravated 76.96 11.15 1745 241724 243307 46199286
Blood pressure diastolic decreased 76.71 11.15 204 243265 14007 46428586
Second primary malignancy 76.10 11.15 129 243340 6455 46436138
Injection site haemorrhage 74.22 11.15 10 243459 20699 46421894
Accidental overdose 73.58 11.15 9 243460 20057 46422536
Pruritus 72.72 11.15 861 242608 241491 46201102
Autoimmune haemolytic anaemia 72.70 11.15 100 243369 4158 46438435
Smooth muscle cell neoplasm 72.68 11.15 42 243427 521 46442072
Lymphoma 72.45 11.15 159 243310 9654 46432939
Flatulence 72.23 11.15 30 243439 28848 46413745
Blood immunoglobulin G decreased 71.94 11.15 67 243402 1801 46440792
Skin ulcer 71.42 11.15 347 243122 32111 46410482
Blood alkaline phosphatase increased 71.20 11.15 61 243408 39548 46403045
Red cell distribution width decreased 71.18 11.15 49 243420 840 46441753
Blood cholesterol increased 71.00 11.15 403 243066 39610 46402983
Deformity 70.77 11.15 132 243337 7125 46435468
Exposure during pregnancy 70.57 11.15 307 243162 107905 46334688
Oxygen saturation decreased 70.29 11.15 608 242861 68556 46374037
Urinary tract infection 69.80 11.15 773 242696 219493 46223100
Fine motor skill dysfunction 69.45 11.15 91 243378 3609 46438984
Blood pressure systolic increased 69.37 11.15 316 243153 28471 46414122
Sedation 69.35 11.15 17 243452 22893 46419700
Red blood cell sedimentation rate 69.07 11.15 64 243405 1709 46440884
Central nervous system lymphoma 68.66 11.15 55 243414 1199 46441394
Seronegative arthritis 68.62 11.15 45 243424 709 46441884
Haemophagocytic lymphohistiocytosis 68.33 11.15 141 243328 8201 46434392
Hypophagia 67.76 11.15 34 243435 29272 46413321
Infusion site reaction 67.27 11.15 63 243406 1706 46440887
Aspergillus infection 66.79 11.15 125 243344 6765 46435828
Depression 66.52 11.15 567 242902 169537 46273056
Injection site rash 66.37 11.15 4 243465 15809 46426784
Restlessness 66.33 11.15 25 243444 25499 46417094
Blood creatine phosphokinase increased 65.87 11.15 31 243438 27693 46414900
Surgery 65.65 11.15 34 243435 28751 46413842
Product substitution issue 65.61 11.15 3 243466 15028 46427565
Cerebral toxoplasmosis 65.27 11.15 43 243426 683 46441910
Vascular access complication 65.25 11.15 48 243421 918 46441675
Haematotoxicity 65.00 11.15 124 243345 6809 46435784
Abnormal behaviour 64.98 11.15 15 243454 21043 46421550
Nightmare 64.56 11.15 6 243463 16592 46426001
Haematemesis 64.26 11.15 35 243434 28771 46413822
Disturbance in attention 63.90 11.15 43 243426 31517 46411076
Blood potassium decreased 63.24 11.15 63 243406 38000 46404593
Pre-existing disease 62.88 11.15 26 243443 143 46442450
Chronic kidney disease 61.96 11.15 73 243396 40798 46401795
Osteonecrosis of jaw 61.81 11.15 53 243416 34349 46408244
Glomerulonephritis 61.70 11.15 57 243412 1516 46441077
Gastric disorder 61.29 11.15 289 243180 26416 46416177
Laryngeal disorder 61.28 11.15 44 243425 809 46441784
Accidental exposure to product 61.22 11.15 17 243452 21064 46421529
Arthrodesis 61.13 11.15 67 243402 2197 46440396
Lymphoma transformation 60.99 11.15 25 243444 134 46442459
Pancytopenia 60.79 11.15 695 242774 84363 46358230
Mean platelet volume decreased 60.29 11.15 56 243413 1500 46441093
Posterior reversible encephalopathy syndrome 60.28 11.15 195 243274 14946 46427647
Acquired haemophilia 60.06 11.15 45 243424 886 46441707
Caesarean section 59.54 11.15 8 243461 16595 46425998
Blood urea increased 59.24 11.15 29 243440 25323 46417270
Injection site bruising 59.18 11.15 59 243410 35577 46407016
Mobility decreased 59.14 11.15 528 242941 60066 46382527
Hepatitis E 58.77 11.15 50 243419 1189 46441404
Therapy responder 58.21 11.15 31 243438 324 46442269
Renal failure 57.81 11.15 351 243118 113243 46329350
Speech disorder 57.67 11.15 62 243407 36105 46406488
Skin exfoliation 57.67 11.15 52 243417 32886 46409707
Varicella zoster virus infection 57.55 11.15 66 243403 2277 46440316
Lymphopenia 57.34 11.15 193 243276 15100 46427493
Interstitial lung disease 57.31 11.15 479 242990 53470 46389123
Dry skin 57.25 11.15 78 243391 40938 46401655
Sensitivity to weather change 57.16 11.15 103 243366 5413 46437180
Anaemia 57.10 11.15 964 242505 254815 46187778
Palpitations 56.91 11.15 279 243190 94980 46347613
Thrombocytopenia 56.50 11.15 951 242518 125630 46316963
Coronary artery disease 55.91 11.15 56 243413 33696 46408897
Vasculitis 55.87 11.15 178 243291 13533 46429060
Withdrawal syndrome 55.79 11.15 13 243456 18121 46424472
Hypotension 55.76 11.15 865 242604 231724 46210869
Mental status changes 55.66 11.15 70 243399 38018 46404575
Pulmonary toxicity 55.64 11.15 93 243376 4600 46437993
Psoriasis 55.61 11.15 216 243253 78388 46364205
Humoral immune defect 55.42 11.15 19 243450 55 46442538
Product administration error 55.09 11.15 17 243452 19664 46422929
Aggression 54.70 11.15 25 243444 22719 46419874
Epistaxis 54.10 11.15 164 243305 64141 46378452
Blood glucose decreased 53.45 11.15 16 243453 18876 46423717
Loss of consciousness 53.23 11.15 338 243131 107900 46334693
Blood bilirubin increased 52.96 11.15 60 243409 34124 46408469
Vertigo 52.72 11.15 121 243348 51927 46390666
Meningoencephalitis viral 52.63 11.15 28 243441 292 46442301
Therapeutic response unexpected 52.63 11.15 9 243460 15607 46426986
Immunoglobulins decreased 52.60 11.15 40 243429 806 46441787
Fluid overload 52.46 11.15 39 243430 27146 46415447
Joint destruction 52.37 11.15 72 243397 2992 46439601
Diabetic ketoacidosis 52.30 11.15 15 243454 18195 46424398
Hypocalcaemia 52.24 11.15 38 243431 26747 46415846
Rectal haemorrhage 52.14 11.15 74 243395 38181 46404412
Neuropathy peripheral 52.14 11.15 270 243199 90623 46351970
Neutropenic sepsis 52.06 11.15 162 243307 12162 46430431
Balance disorder 51.85 11.15 168 243301 64353 46378240
Febrile bone marrow aplasia 51.59 11.15 112 243357 6750 46435843
Palmar-plantar erythrodysaesthesia syndrome 51.54 11.15 21 243448 20430 46422163
Bone swelling 51.11 11.15 46 243423 1182 46441411
Underdose 51.08 11.15 19 243450 19539 46423054
Full blood count decreased 51.00 11.15 26 243443 22185 46420408
Nervousness 51 11.15 44 243425 28431 46414162
Pulmonary hypertension 50.69 11.15 68 243401 35925 46406668
Head injury 50.64 11.15 33 243436 24603 46417990
Dislocation of vertebra 50.39 11.15 47 243422 1266 46441327
Pneumocystis jirovecii infection 50.18 11.15 46 243423 1211 46441382
Hyperlipidaemia 50.15 11.15 17 243452 18522 46424071
Electric shock 50.13 11.15 40 243429 867 46441726
Wrist deformity 49.91 11.15 50 243419 1474 46441119
Psoriatic arthropathy 49.89 11.15 343 243126 36036 46406557
Soft tissue disorder 49.69 11.15 83 243386 4103 46438490
Hyperglycaemia 49.65 11.15 66 243403 35005 46407588
Disease progression 49.54 11.15 709 242760 90591 46352002
Product storage error 49.44 11.15 3 243466 11789 46430804
Hypoaesthesia 49.28 11.15 390 243079 118479 46324114
Pulmonary oedema 49.23 11.15 122 243347 50983 46391610
Mean cell volume decreased 48.91 11.15 62 243407 2378 46440215
Heart rate decreased 48.90 11.15 308 243161 31415 46411178
Injection site warmth 48.53 11.15 7 243462 13765 46428828
Blood pressure increased 48.51 11.15 929 242540 125737 46316856
Peptic ulcer haemorrhage 48.30 11.15 41 243428 972 46441621
Urinary retention 48.24 11.15 39 243430 26022 46416571
Tenosynovitis 48.00 11.15 115 243354 7400 46435193
Swollen tongue 47.85 11.15 49 243420 29183 46413410
Injection site mass 47.85 11.15 10 243459 15030 46427563
Hypercalcaemia 47.74 11.15 227 243242 20819 46421774
Blood iron abnormal 47.56 11.15 70 243399 3100 46439493
B-cell lymphoma refractory 47.35 11.15 18 243451 76 46442517
Generalised tonic-clonic seizure 47.26 11.15 43 243426 27079 46415514
Wheezing 47.20 11.15 133 243336 53253 46389340
Chronic obstructive pulmonary disease 47.05 11.15 149 243320 57484 46385109
Back pain 47.05 11.15 791 242678 209248 46233345
Road traffic accident 47.00 11.15 33 243436 23658 46418935
Orthostatic hypotension 46.78 11.15 36 243433 24622 46417971
Cytopenia 46.56 11.15 116 243353 7652 46434941
Angioedema 46.19 11.15 84 243385 39258 46403335
Mental disorder 46.15 11.15 30 243439 22395 46420198
Adjustment disorder with depressed mood 46.06 11.15 42 243427 1098 46441495
Hallucination, visual 45.62 11.15 18 243451 17855 46424738
Tachycardia 45.52 11.15 318 243151 99304 46343289
Foetal exposure during pregnancy 45.46 11.15 56 243413 30691 46411902
Pulmonary arterial hypertension 45.31 11.15 41 243428 25887 46416706
Fluid retention 45.26 11.15 127 243342 50919 46391674
Cardiac disorder 45.20 11.15 101 243368 43757 46398836
Product label confusion 45.03 11.15 26 243443 322 46442271
Depressed mood 44.87 11.15 65 243404 33254 46409339
Injection site urticaria 44.79 11.15 5 243464 11962 46430631
Panic attack 44.57 11.15 25 243444 20217 46422376
West Nile viral infection 44.54 11.15 27 243442 368 46442225
Device malfunction 44.43 11.15 8 243461 13366 46429227
Dysarthria 44.08 11.15 80 243389 37418 46405175
Abdominal pain lower 44.05 11.15 28 243441 21153 46421440
Extrapyramidal disorder 44.02 11.15 4 243465 11264 46431329
Musculoskeletal pain 43.97 11.15 559 242910 69569 46373024
Dystonia 43.97 11.15 4 243465 11253 46431340
Ankle operation 43.84 11.15 42 243427 1171 46441422
Chromaturia 43.82 11.15 12 243457 15007 46427586
Mantle cell lymphoma 43.64 11.15 31 243438 560 46442033
Metastases to liver 43.39 11.15 24 243445 19561 46423032
Peripheral swelling 43.29 11.15 1105 242364 156966 46285627
Lung disorder 43.11 11.15 379 243090 42925 46399668
Musculoskeletal disorder 43.08 11.15 178 243291 15367 46427226
Blood calcium decreased 43.04 11.15 14 243455 15659 46426934
Abortion spontaneous 42.98 11.15 103 243366 43543 46399050
Drug reaction with eosinophilia and systemic symptoms 42.45 11.15 55 243414 29493 46413100
Device dislocation 42.43 11.15 31 243438 21771 46420822
Blood sodium decreased 42.14 11.15 31 243438 21695 46420898
Hepatic function abnormal 41.76 11.15 72 243397 34349 46408244
Drug level increased 41.73 11.15 22 243447 18419 46424174
Nodule 41.16 11.15 176 243293 15429 46427164
Delusion 41.07 11.15 5 243464 11183 46431410
Drug-induced liver injury 40.99 11.15 43 243426 25325 46417268
Cardiomegaly 40.84 11.15 20 243449 17462 46425131
Metastases to bone 40.82 11.15 20 243449 17456 46425137
Drug eruption 40.62 11.15 219 243250 21110 46421483
Temperature regulation disorder 40.39 11.15 67 243402 3293 46439300
Hypersomnia 40.32 11.15 15 243454 15424 46427169
Cholecystitis chronic 40.29 11.15 4 243465 10495 46432098
Nail disorder 40.26 11.15 111 243358 7785 46434808
Neck deformity 40.20 11.15 49 243420 1805 46440788
Cellulitis 40.19 11.15 209 243260 70079 46372514
Eye pain 40.15 11.15 52 243417 27888 46414705
Jaundice 40.11 11.15 55 243414 28790 46413803
Mucosal inflammation 39.77 11.15 343 243126 38633 46403960
Therapy interrupted 39.18 11.15 5 243464 10786 46431807
Urinary incontinence 39.07 11.15 55 243414 28475 46414118
Haemoglobin decreased 39.04 11.15 457 243012 128492 46314101
Frequent bowel movements 38.97 11.15 9 243460 12623 46429970
Monocyte count increased 38.46 11.15 83 243386 4981 46437612
Right ventricular failure 38.22 11.15 18 243451 16075 46426518
Ankle arthroplasty 38.06 11.15 29 243440 586 46442007
Transfusion 37.81 11.15 11 243458 13220 46429373
Mean cell haemoglobin decreased 37.63 11.15 60 243409 2852 46439741
Acute myocardial infarction 37.62 11.15 68 243401 31856 46410737
Blood potassium increased 37.29 11.15 21 243448 16946 46425647
Complication associated with device 37.09 11.15 17 243452 15424 46427169
Pancreatitis 36.88 11.15 111 243358 43516 46399077
Blood pressure decreased 36.73 11.15 163 243306 56996 46385597
Blood count abnormal 36.68 11.15 24 243445 17854 46424739
Sinus bradycardia 36.65 11.15 13 243456 13769 46428824
Mesenteritis 36.34 11.15 17 243452 131 46442462
Mantle cell lymphoma recurrent 35.98 11.15 16 243453 108 46442485
Abdominal distension 35.57 11.15 230 243239 73121 46369472
Osteoarthritis 35.38 11.15 486 242983 61539 46381054
Finger deformity 35.15 11.15 81 243388 5081 46437512
Joint range of motion decreased 34.94 11.15 164 243305 14960 46427633
Transient ischaemic attack 34.65 11.15 82 243387 34821 46407772
Unevaluable event 34.53 11.15 124 243345 46051 46396542
Lupus nephritis 34.28 11.15 50 243419 2196 46440397
Fear 34.15 11.15 21 243448 16151 46426442
Back injury 34.01 11.15 96 243373 6825 46435768
Haematoma 34.00 11.15 72 243397 31800 46410793
Wrist surgery 33.75 11.15 30 243439 758 46441835
Lip swelling 33.75 11.15 50 243419 25345 46417248
Eye swelling 33.70 11.15 33 243436 20070 46422523
Gamma-glutamyltransferase increased 33.61 11.15 72 243397 31668 46410925
Anger 33.60 11.15 10 243459 11842 46430751
Femur fracture 33.57 11.15 91 243378 36906 46405687
Epstein-Barr virus associated lymphoproliferative disorder 33.55 11.15 40 243429 1439 46441154
Neck mass 33.50 11.15 61 243408 3232 46439361
Pallor 33.40 11.15 43 243426 23123 46419470
Swollen joint count increased 33.17 11.15 51 243418 2349 46440244
Visual acuity reduced 32.98 11.15 40 243429 22073 46420520
Hip fracture 32.71 11.15 55 243414 26501 46416092
Respiratory depression 32.50 11.15 10 243459 11590 46431003
Muscular weakness 32.44 11.15 314 243155 91530 46351063
Ocular hyperaemia 32.31 11.15 33 243436 19677 46422916
Syncope 32.27 11.15 370 243099 104433 46338160
Acute myeloid leukaemia 32.10 11.15 165 243304 15613 46426980
Obstructive airways disorder 31.86 11.15 15 243454 13397 46429196
Haemodialysis 31.76 11.15 5 243464 9212 46433381
Amnesia 31.67 11.15 111 243358 41520 46401073
Cholelithiasis 31.57 11.15 100 243369 38581 46404012
Coagulopathy 31.44 11.15 30 243439 18469 46424124
Breast cancer metastatic 31.42 11.15 16 243453 13662 46428931
Malignant neoplasm progression 31.27 11.15 204 243265 64722 46377871
Incorrect product administration duration 31.23 11.15 6 243463 9571 46433022
Hypomagnesaemia 31.23 11.15 42 243427 22168 46420425
Faeces discoloured 31.22 11.15 25 243444 16762 46425831
Injection site induration 31.21 11.15 3 243466 8076 46434517
Myoclonus 31.20 11.15 18 243451 14334 46428259
Lipase increased 31.20 11.15 4 243465 8599 46433994
Renal injury 31.07 11.15 6 243463 9535 46433058
Mania 31.02 11.15 9 243460 10837 46431756
Incorrect route of product administration 30.97 11.15 24 243445 16359 46426234
Adenovirus infection 30.81 11.15 54 243415 2776 46439817
Ventricular tachycardia 30.65 11.15 26 243443 16941 46425652
Contusion 30.52 11.15 300 243169 87187 46355406
Intestinal sepsis 30.23 11.15 18 243451 237 46442356
Ventricular extrasystoles 30.17 11.15 10 243459 11053 46431540
Pollakiuria 30.11 11.15 50 243419 24211 46418382
Thyroid neoplasm 30.03 11.15 62 243407 3607 46438986
Cytomegalovirus colitis 30.00 11.15 41 243428 1694 46440899
Oedema 29.70 11.15 216 243253 66855 46375738
Psychotic disorder 29.61 11.15 45 243424 22576 46420017
Product complaint 29.57 11.15 13 243456 12088 46430505
Gastrosplenic fistula 29.40 11.15 11 243458 44 46442549
Sinus tachycardia 29.38 11.15 42 243427 21607 46420986
Bronchiectasis 29.31 11.15 111 243358 9205 46433388
Gene mutation 29.23 11.15 32 243437 1048 46441545
Influenza like illness 29.21 11.15 178 243291 57392 46385201
Stevens-Johnson syndrome 28.93 11.15 48 243421 23249 46419344
Dermatitis contact 28.93 11.15 4 243465 8119 46434474
Rhinorrhoea 28.80 11.15 139 243330 47526 46395067
Episcleritis 28.68 11.15 27 243442 736 46441857
Nerve injury 28.67 11.15 97 243372 7608 46434985
Acute hepatitis B 28.62 11.15 19 243450 306 46442287
Hypoxia 28.59 11.15 156 243313 51682 46390911
Oesophagitis 28.45 11.15 18 243451 13633 46428960
Affect lability 28.44 11.15 4 243465 8016 46434577
Device difficult to use 28.36 11.15 4 243465 8000 46434593
X-ray abnormal 28.24 11.15 33 243436 1162 46441431
Proteinuria 28.23 11.15 165 243304 16388 46426205
Injection site hypersensitivity 28.13 11.15 37 243432 1473 46441120
Poor quality sleep 28.01 11.15 23 243446 15230 46427363
Bronchopulmonary aspergillosis 27.57 11.15 94 243375 7402 46435191
Tubulointerstitial nephritis 27.53 11.15 22 243447 14766 46427827
Metastases to central nervous system 27.51 11.15 12 243457 11209 46431384
Hysterectomy 27.43 11.15 4 243465 7802 46434791
Acidosis 27.31 11.15 12 243457 11162 46431431
Accident 27.27 11.15 73 243396 5031 46437562
Cartilage atrophy 27.20 11.15 15 243454 169 46442424
Neck pain 27.06 11.15 422 243047 54884 46387709
Ageusia 26.99 11.15 13 243456 11459 46431134
Injury 26.83 11.15 128 243341 43899 46398694
Extranodal marginal zone B-cell lymphoma (MALT type) 26.80 11.15 21 243448 443 46442150
Cystitis haemorrhagic 26.78 11.15 58 243411 3489 46439104
Pancreatitis acute 26.68 11.15 56 243413 24816 46417777
Rheumatic disorder 26.61 11.15 35 243434 1393 46441200
Onychomadesis 26.58 11.15 51 243418 2812 46439781
Larynx irritation 26.46 11.15 13 243456 113 46442480
Altered state of consciousness 26.39 11.15 51 243418 23297 46419296
Hypokinesia 26.38 11.15 13 243456 11309 46431284
Dyspnoea exertional 26.30 11.15 154 243315 50135 46392458
Melaena 26.20 11.15 67 243402 27705 46414888
Cytomegalovirus viraemia 25.93 11.15 66 243403 4412 46438181
Seasonal allergy 25.89 11.15 19 243450 13315 46429278
Nasal congestion 25.88 11.15 146 243323 47967 46394626
Delirium 25.87 11.15 103 243366 37125 46405468
Viral upper respiratory tract infection 25.81 11.15 88 243381 6930 46435663
Intervertebral discitis 25.78 11.15 47 243422 2492 46440101
Blood pressure diastolic increased 25.67 11.15 79 243390 5895 46436698
Prothrombin time prolonged 25.61 11.15 9 243460 9587 46433006
Vulvovaginal ulceration 25.57 11.15 6 243463 0 46442593
Cytokine release syndrome 25.55 11.15 81 243388 6142 46436451
Rash papular 25.54 11.15 18 243451 12880 46429713
Red blood cell count decreased 25.47 11.15 86 243383 32537 46410056
Torsade de pointes 25.36 11.15 16 243453 12138 46430455
Anuria 25.33 11.15 14 243455 11417 46431176
Lower respiratory tract infection 25.32 11.15 416 243053 54673 46387920
Platelet count abnormal 25.27 11.15 49 243420 2723 46439870
Osteonecrosis 25.15 11.15 61 243408 25683 46416910
Septic shock 25.09 11.15 433 243036 57460 46385133
Post procedural complication 25.03 11.15 27 243442 15702 46426891
Erythropoiesis abnormal 24.90 11.15 16 243453 243 46442350
Pulmonary mass 24.85 11.15 169 243300 17688 46424905
Pelvic pain 24.59 11.15 15 243454 11587 46431006
Diverticulum 24.44 11.15 14 243455 11192 46431401
Impaired gastric emptying 24.43 11.15 95 243374 7977 46434616
Rheumatic fever 24.40 11.15 49 243420 2794 46439799
Cervix disorder 24.40 11.15 20 243449 451 46442142
Haematocrit decreased 24.36 11.15 97 243372 34960 46407633
Cytomegalovirus infection reactivation 24.28 11.15 34 243435 1438 46441155
Dysstasia 24.25 11.15 34 243435 17634 46424959
Blood calcium increased 24.23 11.15 5 243464 7582 46435011
Pneumonia aspiration 24.22 11.15 84 243385 31521 46411072
Cryoglobulinaemia 24.13 11.15 18 243451 352 46442241
Leukoerythroblastosis 23.97 11.15 15 243454 217 46442376
Genital haemorrhage 23.94 11.15 3 243466 6563 46436030
Parkinsonism 23.86 11.15 6 243463 7942 46434651
Hyperhidrosis 23.85 11.15 325 243144 88983 46353610
Overlap syndrome 23.82 11.15 22 243447 585 46442008
Meningitis enteroviral 23.67 11.15 7 243462 10 46442583
Encephalitis 23.64 11.15 89 243380 7359 46435234
Eating disorder 23.49 11.15 25 243444 14629 46427964
Bunion operation 23.47 11.15 25 243444 793 46441800
Blood lactate dehydrogenase abnormal 23.46 11.15 16 243453 270 46442323
Pneumonia cytomegaloviral 23.45 11.15 39 243430 1921 46440672
Limb operation 23.42 11.15 53 243416 3285 46439308
Dizziness postural 23.37 11.15 3 243466 6443 46436150
Human herpesvirus 6 infection 23.33 11.15 44 243425 2395 46440198
Mydriasis 23.28 11.15 13 243456 10540 46432053
Thinking abnormal 23.27 11.15 11 243458 9803 46432790
Genitourinary tract infection 23.23 11.15 13 243456 151 46442442
Vaginal haemorrhage 23.21 11.15 63 243406 25541 46417052
Toxic epidermal necrolysis 23.20 11.15 51 243418 22227 46420366
Precancerous cells present 23.14 11.15 30 243439 1177 46441416
Glycosylated haemoglobin increased 23.14 11.15 14 243455 10862 46431731
Dialysis 22.99 11.15 12 243457 10104 46432489
Nephrotic syndrome 22.96 11.15 67 243402 4854 46437739
Campylobacter gastroenteritis 22.96 11.15 18 243451 380 46442213
Amyotrophic lateral sclerosis 22.89 11.15 28 243441 1035 46441558
Device breakage 22.77 11.15 11 243458 9681 46432912
Oral pruritus 22.48 11.15 33 243436 1458 46441135
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.48 11.15 38 243431 1897 46440696
Skin discolouration 22.34 11.15 91 243378 32589 46410004
Infection reactivation 22.24 11.15 24 243445 773 46441820
Mood altered 22.21 11.15 21 243448 12986 46429607
Citrobacter bacteraemia 22.21 11.15 7 243462 14 46442579
Upper gastrointestinal haemorrhage 22.20 11.15 33 243436 16705 46425888
Chest discomfort 22.17 11.15 334 243135 89935 46352658
Angina unstable 22.08 11.15 6 243463 7542 46435051
Dysuria 21.99 11.15 73 243396 27760 46414833
Anovulatory cycle 21.93 11.15 12 243457 133 46442460
Electrolyte imbalance 21.85 11.15 35 243434 17191 46425402
Flank pain 21.83 11.15 18 243451 11895 46430698
Heart rate abnormal 21.81 11.15 52 243417 3335 46439258
Chronic lymphocytic leukaemia transformation 21.78 11.15 8 243461 30 46442563
5q minus syndrome 21.71 11.15 13 243456 173 46442420
Bone density abnormal 21.67 11.15 49 243420 3035 46439558
Burning sensation 21.66 11.15 139 243330 44272 46398321
Hypothermia 21.60 11.15 19 243450 12164 46430429
Infusion site pain 21.51 11.15 13 243456 10094 46432499
Transplant rejection 21.40 11.15 103 243366 9493 46433100
Blood triglycerides increased 21.35 11.15 18 243451 11765 46430828
Muscle spasticity 21.32 11.15 17 243452 11423 46431170
Urine output decreased 21.31 11.15 16 243453 11081 46431512
Toxic neuropathy 21.28 11.15 17 243452 369 46442224
Retching 21.24 11.15 22 243447 13035 46429558
Infected seroma 21.12 11.15 9 243460 54 46442539
Wheelchair user 21.09 11.15 57 243412 3951 46438642
Cestode infection 21.07 11.15 15 243454 272 46442321
Cardiogenic shock 21.05 11.15 33 243436 16351 46426242
Ocular lymphoma 20.99 11.15 9 243460 55 46442538
Hypoglobulinaemia 20.97 11.15 6 243463 7 46442586
Muscle rigidity 20.94 11.15 13 243456 9948 46432645
Visual impairment 20.69 11.15 235 243234 66454 46376139
Diffuse alveolar damage 20.65 11.15 23 243446 768 46441825
Anaphylactic shock 20.63 11.15 47 243422 20227 46422366
Duodenal ulcer 20.63 11.15 6 243463 7212 46435381
Clear cell renal cell carcinoma 20.60 11.15 26 243443 993 46441600
Atrial septal defect 20.58 11.15 4 243465 6328 46436265
CD4 lymphocytes decreased 20.57 11.15 33 243436 1577 46441016
Procedural pain 20.56 11.15 23 243446 13156 46429437
Conjunctival scar 20.49 11.15 7 243462 20 46442573
Renal disorder 20.39 11.15 71 243398 26615 46415978
Deep vein thrombosis 20.34 11.15 293 243176 79480 46363113
Creutzfeldt-Jakob disease 20.33 11.15 9 243460 60 46442533
Nocturia 20.25 11.15 6 243463 7126 46435467
Treatment noncompliance 20.19 11.15 83 243386 29648 46412945
Premature baby 20.09 11.15 40 243429 18072 46424521
Peritonitis bacterial 20.06 11.15 10 243459 8643 46433950
Joint dislocation 20.06 11.15 113 243356 11073 46431520
Multiple system atrophy 19.98 11.15 13 243456 202 46442391
Cardiomyopathy 19.97 11.15 148 243321 15925 46426668
Malignant transformation 19.82 11.15 15 243454 300 46442293
Food allergy 19.70 11.15 80 243389 6853 46435740
Blood lactic acid increased 19.65 11.15 3 243466 5654 46436939
Retinal deposits 19.62 11.15 9 243460 66 46442527
Cardiac failure 19.56 11.15 296 243173 79652 46362941
Wrong product administered 19.52 11.15 3 243466 5627 46436966
Refractory anaemia with an excess of blasts 19.51 11.15 17 243452 418 46442175
Inappropriate antidiuretic hormone secretion 19.49 11.15 27 243442 14075 46428518
Abortion induced 19.43 11.15 15 243454 10245 46432348
Sarcoidosis 19.24 11.15 65 243404 5094 46437499
Blood immunoglobulin A decreased 19.24 11.15 15 243454 314 46442279
B-cell small lymphocytic lymphoma 19.11 11.15 7 243462 26 46442567
Low density lipoprotein increased 19.06 11.15 4 243465 5996 46436597
B-lymphocyte count abnormal 19.06 11.15 8 243461 46 46442547
Circulatory collapse 19.01 11.15 54 243415 21570 46421023
Maternal drugs affecting foetus 19.00 11.15 3 243466 5515 46437078
Mitral valve incompetence 18.95 11.15 44 243425 18808 46423785
Gestational diabetes 18.87 11.15 7 243462 7212 46435381
Nail bed inflammation 18.82 11.15 16 243453 380 46442213
Breast pain 18.81 11.15 8 243461 7586 46435007
Opsoclonus myoclonus 18.79 11.15 11 243458 140 46442453
Disseminated varicella zoster virus infection 18.74 11.15 21 243448 706 46441887
Cognitive disorder 18.73 11.15 114 243355 36769 46405824
T-lymphocyte count increased 18.66 11.15 10 243459 106 46442487
Pneumonia viral 18.47 11.15 76 243393 6548 46436045
Concomitant disease aggravated 18.44 11.15 9 243460 7873 46434720
Immunodeficiency common variable 18.42 11.15 10 243459 109 46442484
Sleep apnoea syndrome 18.39 11.15 57 243412 22144 46420449
Tumour flare 18.37 11.15 14 243455 283 46442310
Lymphadenectomy 18.33 11.15 23 243446 873 46441720
Tricuspid valve incompetence 18.23 11.15 27 243442 13690 46428903
Needle issue 18.17 11.15 4 243465 5800 46436793
CD4 lymphocytes increased 18.14 11.15 11 243458 150 46442443
Gastritis 18.12 11.15 105 243364 34273 46408320
Malignant melanoma 18.10 11.15 103 243366 10131 46432462
Incorrect dosage administered 18.06 11.15 32 243437 1659 46440934
Atelectasis 17.98 11.15 45 243424 18745 46423848
Hospice care 17.96 11.15 3 243466 5292 46437301
Atrioventricular block first degree 17.94 11.15 5 243464 6181 46436412
Nasopharyngitis 17.86 11.15 978 242491 153020 46289573
Myelitis 17.79 11.15 26 243443 1144 46441449
Leukaemic lymphoma 17.77 11.15 9 243460 84 46442509
Systemic candida 17.71 11.15 42 243427 2685 46439908
Allergic oedema 17.65 11.15 21 243448 754 46441839
Cryptococcosis 17.64 11.15 22 243447 830 46441763
Glomerular filtration rate decreased 17.60 11.15 21 243448 11673 46430920
Ascites 17.58 11.15 115 243354 36469 46406124
Eructation 17.57 11.15 8 243461 7287 46435306
Skin irritation 17.54 11.15 8 243461 7279 46435314
Face oedema 17.46 11.15 47 243422 19106 46423487
Feeling jittery 17.40 11.15 19 243450 10989 46431604
Selective IgG subclass deficiency 17.40 11.15 5 243464 6 46442587
Central nervous system vasculitis 17.38 11.15 23 243446 921 46441672
Non-Hodgkin's lymphoma 17.37 11.15 30 243439 1524 46441069
Haemoptysis 17.24 11.15 74 243395 26115 46416478
Haemorrhoids 17.17 11.15 46 243423 18731 46423862
Gastric stenosis 17.17 11.15 8 243461 61 46442532
JC polyomavirus test positive 17.13 11.15 23 243446 934 46441659
Cyanosis 17.10 11.15 36 243433 15935 46426658
Pulseless electrical activity 17.05 11.15 8 243461 7159 46435434
Myeloid leukaemia 17.03 11.15 14 243455 317 46442276
Lip pruritus 17.03 11.15 17 243452 499 46442094
Acute respiratory failure 17.01 11.15 86 243383 29052 46413541
Aplasia 16.99 11.15 49 243420 3527 46439066
Polyomavirus-associated nephropathy 16.96 11.15 29 243440 1461 46441132
Lower limb fracture 16.88 11.15 24 243445 12374 46430219
Amenorrhoea 16.85 11.15 13 243456 8882 46433711
Hypovolaemia 16.84 11.15 16 243453 9872 46432721
Enterococcal bacteraemia 16.82 11.15 26 243443 1203 46441390
Mucocutaneous leishmaniasis 16.81 11.15 14 243455 323 46442270
COVID-19 16.67 11.15 159 243310 18416 46424177
Arteriosclerosis coronary artery 16.66 11.15 11 243458 8145 46434448
Iron deficiency anaemia 16.62 11.15 41 243428 17165 46425428
Amylase increased 16.62 11.15 4 243465 5455 46437138
Chronic hepatitis 16.62 11.15 21 243448 803 46441790
Tooth loss 16.58 11.15 7 243462 6666 46435927
Babesiosis 16.57 11.15 7 243462 41 46442552
Dementia 16.54 11.15 33 243436 14897 46427696
Hyperbilirubinaemia 16.52 11.15 18 243451 10420 46432173
Eye irritation 16.52 11.15 39 243430 16575 46426018
Subclavian artery occlusion 16.44 11.15 6 243463 22 46442571
Concussion 16.38 11.15 8 243461 6995 46435598
Dermatomyositis 16.36 11.15 34 243435 1987 46440606
Bradyphrenia 16.36 11.15 6 243463 6224 46436369
Complication of device insertion 16.33 11.15 3 243466 4941 46437652
Primary immunodeficiency syndrome 16.29 11.15 7 243462 43 46442550
Arteriosclerosis 16.29 11.15 16 243453 9717 46432876
Ganglioneuroma 16.26 11.15 10 243459 140 46442453
Groin pain 16.24 11.15 14 243455 9051 46433542
Follicle centre lymphoma, follicular grade I, II, III stage IV 16.21 11.15 5 243464 9 46442584
Choking 16.18 11.15 12 243457 8364 46434229
Nail pigmentation 16.16 11.15 11 243458 185 46442408
Musculoskeletal chest pain 16.08 11.15 45 243424 18061 46424532
Infusion site erythema 16.03 11.15 10 243459 7632 46434961
Neck surgery 15.98 11.15 28 243441 1439 46441154
Apathy 15.96 11.15 9 243460 7259 46435334
Oral herpes 15.95 11.15 163 243306 19227 46423366
Lymphoproliferative disorder 15.92 11.15 40 243429 2652 46439941
Combined immunodeficiency 15.90 11.15 9 243460 107 46442486
Localised infection 15.89 11.15 192 243277 23609 46418984
Infusion site swelling 15.81 11.15 5 243464 5694 46436899
Pulmonary embolism 15.80 11.15 438 243031 108147 46334446
Muscle strain 15.75 11.15 8 243461 6841 46435752
Limb mass 15.75 11.15 38 243431 2456 46440137
Blood creatinine increased 15.71 11.15 292 243177 76111 46366482
COVID-19 pneumonia 15.68 11.15 45 243424 3230 46439363
Feeding disorder 15.67 11.15 18 243451 10176 46432417
Epilepsy 15.67 11.15 67 243402 23671 46418922
Parotid gland enlargement 15.64 11.15 20 243449 774 46441819
Salivary hypersecretion 15.63 11.15 7 243462 6438 46436155
ADAMTS13 activity decreased 15.59 11.15 8 243461 77 46442516
Nephrogenic systemic fibrosis 15.54 11.15 3 243466 4769 46437824
Middle insomnia 15.51 11.15 16 243453 9499 46433094
Sensory disturbance 15.49 11.15 25 243444 12242 46430351
BK virus infection 15.48 11.15 41 243428 2808 46439785
Colitis ischaemic 15.46 11.15 18 243451 10114 46432479
Hypernatraemia 15.45 11.15 7 243462 6394 46436199
Herpes zoster infection neurological 15.41 11.15 8 243461 79 46442514
Hypercholesterolaemia 15.38 11.15 108 243361 11422 46431171
Mucocutaneous ulceration 15.33 11.15 10 243459 156 46442437
Acute myelomonocytic leukaemia 15.33 11.15 11 243458 202 46442391
Quadrantanopia 15.31 11.15 6 243463 28 46442565
Listeria sepsis 15.30 11.15 17 243452 566 46442027
Acute biphenotypic leukaemia 15.29 11.15 7 243462 51 46442542
Myelosuppression 15.28 11.15 80 243389 7623 46434970
Epstein-Barr virus infection reactivation 15.28 11.15 12 243457 254 46442339
Cholesteatoma 15.28 11.15 9 243460 116 46442477
Escherichia bacteraemia 15.27 11.15 40 243429 2721 46439872
Small intestinal obstruction 15.26 11.15 39 243430 16133 46426460
Bladder disorder 15.21 11.15 9 243460 7069 46435524
Device failure 15.21 11.15 6 243463 5953 46436640
Intestinal obstruction 15.20 11.15 77 243392 25998 46416595
Mycobacterium chelonae infection 15.14 11.15 15 243454 436 46442157
Faecaloma 15.11 11.15 11 243458 7741 46434852
Pain of skin 15.07 11.15 11 243458 7731 46434862
Capillaritis 15.07 11.15 8 243461 83 46442510
Subdural haematoma 15.03 11.15 28 243441 12969 46429624
Pneumonia 14.99 11.15 2209 241260 374111 46068482
Premenstrual syndrome 14.94 11.15 18 243451 655 46441938
Rash macular 14.88 11.15 51 243418 19209 46423384
Compression fracture 14.86 11.15 7 243462 6250 46436343
Microangiopathic haemolytic anaemia 14.84 11.15 15 243454 447 46442146
Gingivitis ulcerative 14.80 11.15 10 243459 166 46442427
Hepatitis B surface antigen positive 14.74 11.15 7 243462 56 46442537
Stem cell transplant 14.64 11.15 30 243439 1736 46440857
Germ cell cancer 14.53 11.15 7 243462 58 46442535
Haemophilus infection 14.51 11.15 21 243448 916 46441677
Juvenile idiopathic arthritis 14.49 11.15 51 243418 4081 46438512
Drug ineffective for unapproved indication 14.48 11.15 140 243329 16273 46426320
Smear cervix abnormal 14.48 11.15 37 243432 2479 46440114
Gout 14.47 11.15 23 243446 11333 46431260
Abnormal loss of weight 14.47 11.15 4 243465 4971 46437622
Illness 14.43 11.15 26 243443 12198 46430395
Respiratory acidosis 14.41 11.15 7 243462 6141 46436452
Tongue disorder 14.39 11.15 75 243394 7135 46435458
Fear of injection 14.38 11.15 51 243418 4096 46438497
Guillain-Barre syndrome 14.34 11.15 44 243425 3278 46439315
Eosinophil count increased 14.27 11.15 12 243457 7854 46434739
Peripheral sensorimotor neuropathy 14.26 11.15 24 243445 1194 46441399
Candida infection 14.24 11.15 178 243291 22062 46420531
Joint prosthesis user 14.22 11.15 6 243463 35 46442558
Application site erythema 14.15 11.15 4 243465 4900 46437693
Non-cardiac chest pain 14.13 11.15 7 243462 6071 46436522
Head discomfort 14.13 11.15 20 243449 10331 46432262
Steroid diabetes 14.10 11.15 17 243452 619 46441974
Micturition urgency 14.09 11.15 12 243457 7805 46434788
Abdominal tenderness 14.04 11.15 10 243459 7118 46435475
Pericardial effusion 14.01 11.15 77 243392 25466 46417127
Extrasystoles 14 11.15 4 243465 4865 46437728
Oliguria 13.98 11.15 15 243454 8744 46433849
Immune thrombocytopenia 13.96 11.15 82 243387 8159 46434434
Bundle branch block left 13.95 11.15 8 243461 6391 46436202
Traumatic lung injury 13.93 11.15 26 243443 1404 46441189
Osteoporosis 13.91 11.15 293 243176 40315 46402278
Inflammatory marker increased 13.86 11.15 61 243408 5414 46437179
Primary mediastinal large B-cell lymphoma recurrent 13.85 11.15 7 243462 65 46442528
Oropharyngeal cancer 13.81 11.15 6 243463 38 46442555
Ischaemic stroke 13.81 11.15 43 243426 16679 46425914
Affective disorder 13.76 11.15 4 243465 4811 46437782
Rheumatoid factor 13.76 11.15 7 243462 66 46442527
Hepatic necrosis 13.71 11.15 6 243463 5595 46436998
Major depression 13.70 11.15 9 243460 6681 46435912
Feeling hot 13.67 11.15 129 243340 37799 46404794
Pyoderma gangrenosum 13.66 11.15 38 243431 2679 46439914
Lacrimation increased 13.66 11.15 40 243429 15821 46426772
Parapsoriasis 13.66 11.15 8 243461 102 46442491
Cold type haemolytic anaemia 13.65 11.15 10 243459 190 46442403
Tooth extraction 13.61 11.15 20 243449 10173 46432420
B-lymphocyte abnormalities 13.56 11.15 5 243464 19 46442574
Hepatitis C RNULL increased 13.55 11.15 9 243460 145 46442448
Knee operation 13.55 11.15 4 243465 4762 46437831
Bacteraemia 13.54 11.15 123 243346 14056 46428537
Refractory cytopenia with unilineage dysplasia 13.52 11.15 16 243453 571 46442022
Diffuse large B-cell lymphoma stage III 13.43 11.15 6 243463 41 46442552
Transient hypogammaglobulinaemia of infancy 13.43 11.15 6 243463 41 46442552
Myocardial ischaemia 13.43 11.15 29 243440 12720 46429873
Pleocytosis 13.42 11.15 15 243454 503 46442090
Premature labour 13.37 11.15 24 243445 11275 46431318
Drug resistance 13.35 11.15 144 243325 17224 46425369
Pulmonary sepsis 13.30 11.15 25 243444 1357 46441236
Magnesium deficiency 13.30 11.15 14 243455 438 46442155
Lymphadenopathy 13.28 11.15 247 243222 33241 46409352
Meningitis cryptococcal 13.27 11.15 23 243446 1172 46441421
Hypotonia 13.23 11.15 14 243455 8215 46434378
Dry mouth 13.22 11.15 204 243265 54722 46387871
Cataract 13.15 11.15 320 243149 45095 46397498
Myelopathy 13.13 11.15 36 243433 2516 46440077
Type 2 diabetes mellitus 13.12 11.15 160 243309 19715 46422878
Osteopenia 13.05 11.15 45 243424 16916 46425677
Intracranial pressure increased 13.03 11.15 3 243466 4217 46438376
Vascular compression 13.01 11.15 8 243461 112 46442481
Chills 12.99 11.15 619 242850 95413 46347180
Central nervous system enteroviral infection 12.99 11.15 5 243464 22 46442571
Nephritic syndrome 12.99 11.15 9 243460 156 46442437
Pneumatosis intestinalis 12.94 11.15 31 243438 1994 46440599
Jaundice cholestatic 12.94 11.15 5 243464 5024 46437569
Subarachnoid haemorrhage 12.92 11.15 24 243445 11129 46431464
Hot flush 12.86 11.15 155 243314 43362 46399231
Atypical femur fracture 12.81 11.15 5 243464 4992 46437601
Tinnitus 12.79 11.15 88 243381 27585 46415008
Encephalitis eastern equine 12.78 11.15 3 243466 0 46442593
SARS-CoV-2 antibody test negative 12.78 11.15 3 243466 0 46442593
Acute flaccid myelitis 12.78 11.15 3 243466 0 46442593
Encephalitis enteroviral 12.78 11.15 3 243466 0 46442593
Chronic lymphocytic leukaemia refractory 12.74 11.15 6 243463 47 46442546
Device leakage 12.74 11.15 6 243463 5359 46437234
Photosensitivity reaction 12.74 11.15 30 243439 12762 46429831
Exercise tolerance decreased 12.73 11.15 4 243465 4573 46438020
Encephalitis viral 12.71 11.15 27 243442 1603 46440990
Sinus disorder 12.70 11.15 44 243425 16519 46426074
Steatohepatitis 12.70 11.15 14 243455 462 46442131
Splenic marginal zone lymphoma recurrent 12.69 11.15 4 243465 8 46442585
Melanoma recurrent 12.68 11.15 7 243462 79 46442514
Monoclonal gammopathy 12.68 11.15 16 243453 611 46441982
Mycobacterial infection 12.67 11.15 27 243442 1606 46440987
Post procedural haemorrhage 12.67 11.15 12 243457 7414 46435179
Coxsackie viral infection 12.64 11.15 5 243464 24 46442569
Erythema migrans 12.64 11.15 5 243464 24 46442569
Marrow hyperplasia 12.64 11.15 15 243454 537 46442056
T-cell lymphoma 12.64 11.15 16 243453 613 46441980
Pulse absent 12.63 11.15 5 243464 4951 46437642
Renal tubular necrosis 12.60 11.15 23 243446 10736 46431857
Eye pruritus 12.59 11.15 27 243442 11871 46430722
Walking aid user 12.55 11.15 54 243415 4746 46437847
Viral sepsis 12.48 11.15 5 243464 25 46442568
Fracture 12.47 11.15 44 243425 16427 46426166
Product dispensing error 12.44 11.15 18 243451 9215 46433378
Metastases to lung 12.41 11.15 23 243446 10673 46431920
Psychiatric symptom 12.38 11.15 4 243465 4493 46438100
Biopsy bone marrow abnormal 12.37 11.15 11 243458 278 46442315
Dermatitis acneiform 12.36 11.15 3 243466 4067 46438526
Pharyngeal disorder 12.31 11.15 26 243443 1537 46441056
Frustration tolerance decreased 12.30 11.15 6 243463 5251 46437342
Gastrointestinal motility disorder 12.30 11.15 4 243465 4474 46438119
Dermatitis bullous 12.30 11.15 13 243456 7630 46434963
Photophobia 12.29 11.15 37 243432 14507 46428086
Hyperreflexia 12.29 11.15 6 243463 5248 46437345
Impaired work ability 12.26 11.15 110 243359 12526 46430067
Lung diffusion test decreased 12.26 11.15 16 243453 632 46441961
Eyelid oedema 12.26 11.15 22 243447 10335 46432258
Blood lactate dehydrogenase increased 12.25 11.15 162 243307 20338 46422255
Tuberculin test positive 12.24 11.15 39 243430 2965 46439628
Facial pain 12.23 11.15 13 243456 7612 46434981
Internal haemorrhage 12.20 11.15 4 243465 4451 46438142
Muscle tightness 12.09 11.15 22 243447 10283 46432310
CD8 lymphocytes decreased 12.06 11.15 9 243460 176 46442417
Gastroenteritis viral 12.04 11.15 51 243418 18068 46424525
Toxic cardiomyopathy 12.04 11.15 8 243461 129 46442464
Hepatitis B DNULL assay positive 12.02 11.15 5 243464 28 46442565
Renal vasculitis 12.00 11.15 10 243459 231 46442362
Cerebellar stroke 11.98 11.15 9 243460 178 46442415
Catheter site erythema 11.97 11.15 3 243466 3980 46438613
Proctalgia 11.96 11.15 5 243464 4791 46437802
Epstein Barr virus positive mucocutaneous ulcer 11.96 11.15 10 243459 232 46442361
Connective tissue inflammation 11.94 11.15 6 243463 55 46442538
Joint effusion 11.94 11.15 105 243364 11890 46430703
Activated partial thromboplastin time prolonged 11.91 11.15 11 243458 6878 46435715
Remission not achieved 11.90 11.15 7 243462 90 46442503
Gastroenteritis clostridial 11.89 11.15 14 243455 497 46442096
Thrombotic thrombocytopenic purpura 11.82 11.15 46 243423 3864 46438729
Antineutrophil cytoplasmic antibody increased 11.76 11.15 6 243463 57 46442536
Neutrophil count decreased 11.69 11.15 303 243166 43123 46399470
Lichen sclerosus 11.69 11.15 19 243450 918 46441675
Oligohydramnios 11.67 11.15 7 243462 5458 46437135
Cerebral atrophy 11.63 11.15 5 243464 4711 46437882
Dyspepsia 11.62 11.15 270 243199 68202 46374391
Focal segmental glomerulosclerosis 11.62 11.15 24 243445 1397 46441196
Device use error 11.59 11.15 6 243463 5075 46437518
Autoimmune neutropenia 11.58 11.15 6 243463 59 46442534
Heparin-induced thrombocytopenia 11.57 11.15 4 243465 4305 46438288
Mixed hepatocellular cholangiocarcinoma 11.56 11.15 4 243465 12 46442581
Cranial nerve disorder 11.56 11.15 11 243458 304 46442289
Feeling drunk 11.54 11.15 3 243466 3884 46438709
Thirst 11.53 11.15 25 243444 10951 46431642
Aspiration 11.50 11.15 20 243449 9511 46433082
Arthritis infective 11.49 11.15 55 243414 5058 46437535
Drug dependence 11.47 11.15 59 243410 19842 46422751
Anterograde amnesia 11.44 11.15 12 243457 374 46442219
Ventricular fibrillation 11.42 11.15 27 243442 11469 46431124
Sudden death 11.42 11.15 20 243449 9484 46433109
Blood chloride decreased 11.41 11.15 7 243462 5390 46437203
Campylobacter infection 11.38 11.15 16 243453 679 46441914
Neoplasm malignant 11.38 11.15 179 243290 23320 46419273
Pruritus allergic 11.37 11.15 20 243449 1031 46441562
Brain natriuretic peptide increased 11.36 11.15 5 243464 4645 46437948
Myocarditis infectious 11.33 11.15 4 243465 13 46442580
Polyomavirus viraemia 11.26 11.15 12 243457 381 46442212
Jaw fracture 11.22 11.15 34 243435 2515 46440078
Chest wall tumour 11.21 11.15 5 243464 34 46442559
Central nervous system viral infection 11.20 11.15 7 243462 101 46442492
Electrocardiogram abnormal 11.20 11.15 12 243457 7000 46435593
Medication error 11.20 11.15 105 243364 30806 46411787
Complement factor C3 decreased 11.19 11.15 8 243461 146 46442447
Splenectomy 11.19 11.15 13 243456 455 46442138
Lower gastrointestinal haemorrhage 11.17 11.15 13 243456 7307 46435286
Atrioventricular block second degree 11.15 11.15 3 243466 3796 46438797

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1359.72 11.60 1975 128182 104718 29717603
Off label use 1066.83 11.60 2915 127242 246375 29575946
Progressive multifocal leukoencephalopathy 1015.44 11.60 577 129580 8436 29813885
Neutropenia 895.74 11.60 1821 128336 126719 29695602
Intentional product use issue 894.92 11.60 940 129217 35500 29786821
Hepatitis B 738.98 11.60 409 129748 5663 29816658
Product use in unapproved indication 691.27 11.60 1187 128970 72506 29749815
Infusion related reaction 554.77 11.60 778 129379 39786 29782535
Diffuse large B-cell lymphoma recurrent 512.69 11.60 227 129930 1865 29820456
Drug ineffective 491.09 11.60 2828 127329 337559 29484762
Diffuse large B-cell lymphoma 490.46 11.60 346 129811 7495 29814826
Pneumocystis jirovecii pneumonia 445.74 11.60 456 129701 16664 29805657
Hypogammaglobulinaemia 437.54 11.60 277 129880 4975 29817346
Myelodysplastic syndrome 395.35 11.60 447 129710 18331 29803990
Hepatitis B reactivation 372.68 11.60 202 129955 2675 29819646
Completed suicide 370.99 11.60 14 130143 99478 29722843
Rheumatoid arthritis 365.45 11.60 648 129509 40549 29781772
Cytomegalovirus infection 344.39 11.60 468 129689 23206 29799115
Apparent death 338.73 11.60 204 129953 3338 29818983
Lymphoma 327.96 11.60 304 129853 9817 29812504
Synovitis 325.06 11.60 298 129859 9485 29812836
Tumour lysis syndrome 322.38 11.60 336 129821 12549 29809772
Drug interaction 316.57 11.60 243 129914 199325 29622996
Bone marrow failure 309.77 11.60 503 129654 29282 29793039
Contraindicated product administered 309.23 11.60 378 129779 16853 29805468
Chills 295.16 11.60 834 129323 71504 29750817
Toxicity to various agents 281.86 11.60 215 129942 176968 29645353
Overdose 259.35 11.60 31 130126 84306 29738015
Chronic lymphocytic leukaemia 259.17 11.60 191 129966 4437 29817884
Fall 250.25 11.60 253 129904 181619 29640702
Drug intolerance 243.15 11.60 579 129578 44712 29777609
Disease progression 239.00 11.60 827 129330 79047 29743274
Pyrexia 221.98 11.60 2099 128058 292390 29529931
Rhabdomyolysis 220.80 11.60 14 130143 63566 29758755
Post transplant lymphoproliferative disorder 215.11 11.60 181 129976 5125 29817196
Diffuse large B-cell lymphoma refractory 208.88 11.60 90 130067 687 29821634
B-cell lymphoma recurrent 208.11 11.60 85 130072 558 29821763
B-cell lymphoma 201.96 11.60 163 129994 4347 29817974
Lymphopenia 201.74 11.60 267 129890 12896 29809425
Therapy partial responder 201.45 11.60 150 130007 3541 29818780
Agranulocytosis 195.55 11.60 346 129811 21596 29800725
Pancytopenia 191.19 11.60 804 129353 84248 29738073
Product dose omission issue 190.18 11.60 80 130077 91551 29730770
Neutrophil count decreased 184.39 11.60 501 129656 41953 29780368
Treatment failure 181.41 11.60 439 129718 34240 29788081
Chronic lymphocytic leukaemia recurrent 177.08 11.60 68 130089 370 29821951
Lymphadenopathy 176.88 11.60 352 129805 24024 29798297
Second primary malignancy 173.95 11.60 174 129983 6182 29816139
Cytopenia 172.79 11.60 196 129961 8060 29814261
Joint swelling 171.89 11.60 521 129636 46425 29775896
Infection 166.92 11.60 727 129430 77347 29744974
Disease recurrence 164.95 11.60 252 129905 13909 29808412
Febrile bone marrow aplasia 160.66 11.60 187 129970 7910 29814411
Neutropenic sepsis 159.00 11.60 221 129936 11188 29811133
Dizziness 156.10 11.60 389 129768 194520 29627801
Bronchopulmonary aspergillosis 152.19 11.60 225 129932 12059 29810262
Anxiety 150.57 11.60 103 130054 89768 29732553
Somnolence 150.36 11.60 120 130037 96643 29725678
Plasma cell myeloma 149.54 11.60 26 130131 53436 29768885
Mantle cell lymphoma recurrent 147.51 11.60 59 130098 364 29821957
B-lymphocyte count decreased 145.80 11.60 61 130096 429 29821892
Autoimmune haemolytic anaemia 145.36 11.60 129 130028 3930 29818391
Acquired gene mutation 143.40 11.60 79 130078 1082 29821239
Diverticulitis 140.11 11.60 263 129894 17182 29805139
Leukopenia 137.28 11.60 545 129612 55614 29766707
Hypoglycaemia 135.77 11.60 28 130129 50953 29771368
Epstein-Barr virus infection 134.93 11.60 156 130001 6550 29815771
Suicide attempt 130.67 11.60 7 130150 36690 29785631
Hallucination 128.48 11.60 28 130129 49031 29773290
Mantle cell lymphoma 127.64 11.60 81 130076 1460 29820861
Sepsis 123.25 11.60 1070 129087 145325 29676996
Mucosal inflammation 122.64 11.60 350 129807 30144 29792177
Fatigue 119.52 11.60 860 129297 319813 29502508
International normalised ratio increased 115.75 11.60 32 130125 47707 29774614
Herpes zoster 114.94 11.60 338 129819 29605 29792716
Hospitalisation 114.63 11.60 26 130131 44293 29778028
White blood cell count decreased 111.80 11.60 685 129472 83262 29739059
Aggression 109.92 11.60 15 130142 36892 29785429
Pneumocystis jirovecii infection 109.67 11.60 70 130087 1275 29821046
Red blood cell sedimentation rate increased 108.73 11.60 146 130011 7149 29815172
Suicidal ideation 106.79 11.60 15 130142 36099 29786222
Thrombocytopenia 106.26 11.60 984 129173 136060 29686261
Electrocardiogram QT prolonged 105.70 11.60 15 130142 35820 29786501
Chondropathy 104.54 11.60 58 130099 806 29821515
Haematotoxicity 103.67 11.60 131 130026 6039 29816282
Central nervous system lymphoma 103.55 11.60 58 130099 822 29821499
Diarrhoea 102.05 11.60 945 129212 333158 29489163
Acute myeloid leukaemia 101.78 11.60 235 129922 17771 29804550
Muscle spasms 101.19 11.60 80 130077 64758 29757563
Pneumonia cytomegaloviral 100.40 11.60 89 130068 2707 29819614
Depression 99.71 11.60 149 130008 90288 29732033
Confusional state 99.53 11.60 280 129877 134554 29687767
Gait disturbance 99.27 11.60 107 130050 74670 29747651
Cerebrovascular accident 97.51 11.60 132 130025 83345 29738976
Granulomatosis with polyangiitis 96.91 11.60 56 130101 845 29821476
Aspergillus infection 96.10 11.60 165 129992 10049 29812272
Vomiting 95.71 11.60 562 129595 219256 29603065
Inappropriate schedule of product administration 95.62 11.60 27 130130 39701 29782620
Blood creatine phosphokinase increased 94.64 11.60 36 130121 43812 29778509
Onychoclasis 94.08 11.60 69 130088 1590 29820731
Squamous cell carcinoma 93.06 11.60 163 129994 10087 29812234
Intentional product misuse 92.37 11.60 19 130138 34648 29787673
Mineral metabolism disorder 92.31 11.60 40 130117 310 29822011
Pulmonary embolism 91.36 11.60 617 129540 77518 29744803
Atlantoaxial instability 91.03 11.60 39 130118 293 29822028
Pulmonary thrombosis 90.07 11.60 124 130033 6219 29816102
Spinal instability 89.48 11.60 39 130118 307 29822014
Myelosuppression 89.09 11.60 133 130024 7189 29815132
Sarcoidosis 88.44 11.60 82 130075 2647 29819674
Agitation 85.27 11.60 66 130091 54007 29768314
Dislocation of vertebra 84.44 11.60 39 130118 357 29821964
Serum sickness 82.92 11.60 66 130091 1724 29820597
Myocardial infarction 82.62 11.60 275 129882 125350 29696971
Psoriasis 82.07 11.60 41 130116 42465 29779856
JC virus infection 80.79 11.60 65 130092 1725 29820596
Seizure 80.66 11.60 194 129963 98281 29724040
Cardio-respiratory arrest 80.59 11.60 78 130079 57228 29765093
Knee arthroplasty 79.85 11.60 110 130047 5520 29816801
Arthropathy 79.56 11.60 234 129923 20493 29801828
Coronary artery disease 77.98 11.60 61 130096 49651 29772670
Cytomegalovirus chorioretinitis 77.76 11.60 83 130074 3185 29819136
Decreased appetite 76.48 11.60 363 129794 149547 29672774
Cardiac arrest 75.19 11.60 184 129973 92666 29729655
Dehydration 72.89 11.60 283 129874 123256 29699065
Foot deformity 72.60 11.60 82 130075 3355 29818966
Acute kidney injury 71.31 11.60 804 129353 273038 29549283
Acne cystic 70.85 11.60 37 130120 452 29821869
Cytokine release syndrome 70.30 11.60 142 130015 9791 29812530
Bradycardia 70.24 11.60 110 130047 65416 29756905
Pneumonitis 69.92 11.60 270 129887 27184 29795137
Cardiac failure congestive 69.34 11.60 166 129991 84241 29738080
Loss of consciousness 69.33 11.60 151 130006 79224 29743097
Myalgia 68.51 11.60 144 130013 76523 29745798
Lymphoma transformation 67.47 11.60 26 130131 143 29822178
Drug withdrawal syndrome 66.88 11.60 5 130152 19804 29802517
Hyperkalaemia 65.94 11.60 116 130041 65894 29756427
Intervertebral disc space narrowing 65.88 11.60 39 130118 617 29821704
Memory impairment 65.76 11.60 40 130117 37134 29785187
C-reactive protein increased 65.75 11.60 367 129790 43106 29779215
Haemolysis 65.65 11.60 115 130042 7116 29815205
Coma 65.53 11.60 48 130109 40401 29781920
Septic shock 65.41 11.60 487 129670 63120 29759201
Ill-defined disorder 65.03 11.60 142 130015 10342 29811979
Wrong technique in product usage process 64.90 11.60 27 130130 31128 29791193
Herpes simplex 64.49 11.60 88 130069 4376 29817945
Interstitial lung disease 64.25 11.60 465 129692 59732 29762589
Pemphigus 63.84 11.60 49 130108 1212 29821109
No adverse event 63.39 11.60 193 129964 17226 29805095
Constipation 63.22 11.60 264 129893 112642 29709679
Blood pressure diastolic abnormal 62.95 11.60 49 130108 1238 29821083
Dyskinesia 62.41 11.60 10 130147 21824 29800497
Hyperpyrexia 62.29 11.60 66 130091 2511 29819810
Irritability 60.65 11.60 13 130144 23037 29799284
Accidental overdose 60.61 11.60 5 130152 18270 29804051
Pneumonia 60.00 11.60 1887 128270 332419 29489902
Metabolic acidosis 59.98 11.60 45 130112 37416 29784905
Platelet count decreased 59.95 11.60 715 129442 105414 29716907
Malaise 59.92 11.60 452 129705 166510 29655811
Injury 59.81 11.60 11 130146 21720 29800601
B-cell lymphoma refractory 59.80 11.60 22 130135 104 29822217
Insomnia 59.51 11.60 207 129950 93129 29729192
Treatment noncompliance 59.23 11.60 18 130139 25235 29797086
Injection site pain 58.87 11.60 29 130128 30281 29792040
Hyponatraemia 58.55 11.60 128 130029 67074 29755247
Syncope 58.47 11.60 182 129975 84721 29737600
Basal cell carcinoma 58.44 11.60 178 129979 15890 29806431
Coombs positive haemolytic anaemia 57.91 11.60 38 130119 727 29821594
Nausea 57.64 11.60 926 129231 296031 29526290
Venoocclusive liver disease 57.24 11.60 103 130054 6510 29815811
Bladder transitional cell carcinoma 56.08 11.60 61 130096 2392 29819929
Hepatic failure 54.57 11.60 292 129865 33751 29788570
Encephalitis enteroviral 54.17 11.60 22 130135 142 29822179
Diabetic ketoacidosis 54.07 11.60 4 130153 15982 29806339
Synovial cyst 53.79 11.60 51 130106 1694 29820627
Unevaluable event 53.75 11.60 36 130121 31749 29790572
Abnormal behaviour 53.70 11.60 22 130135 25601 29796720
Terminal state 53.51 11.60 72 130085 3532 29818789
Oxygen saturation decreased 53.12 11.60 347 129810 43093 29779228
Posterior reversible encephalopathy syndrome 52.94 11.60 117 130040 8590 29813731
Hepatitis E 52.81 11.60 49 130108 1583 29820738
Cytomegalovirus infection reactivation 52.63 11.60 50 130107 1665 29820656
Rheumatoid factor positive 52.50 11.60 31 130126 488 29821833
Tooth loss 52.50 11.60 75 130082 3894 29818427
Blood pressure systolic abnormal 52.19 11.60 47 130110 1460 29820861
Hallucination, visual 51.84 11.60 5 130152 16108 29806213
Cytology abnormal 51.56 11.60 28 130129 372 29821949
Respiratory arrest 51.03 11.60 32 130125 29226 29793095
Lethargy 50.82 11.60 58 130099 39461 29782860
Microsporidia infection 50.65 11.60 32 130125 572 29821749
Lymphocytosis 50.38 11.60 52 130105 1918 29820403
Stress 50.10 11.60 13 130144 20222 29802099
Polyneuropathy 48.78 11.60 137 130020 11686 29810635
C-reactive protein abnormal 48.27 11.60 87 130070 5506 29816815
Gastrointestinal haemorrhage 48.01 11.60 193 129964 83253 29739068
Chronic lymphocytic leukaemia refractory 47.79 11.60 18 130139 92 29822229
Osteosclerosis 47.07 11.60 40 130117 1148 29821173
Immunosuppression 46.59 11.60 82 130075 5093 29817228
JC polyomavirus test positive 46.54 11.60 30 130127 556 29821765
Intestinal sepsis 46.46 11.60 27 130130 412 29821909
End stage renal disease 46.45 11.60 101 130056 7334 29814987
Lactic acidosis 45.62 11.60 41 130116 31172 29791149
Medication error 45.61 11.60 17 130140 20955 29801366
Lung infiltration 45.55 11.60 139 130018 12420 29809901
Blood pressure fluctuation 45.26 11.60 173 129984 17330 29804991
Drug ineffective for unapproved indication 44.81 11.60 126 130031 10754 29811567
Deep vein thrombosis 44.08 11.60 429 129728 60072 29762249
Blood urea increased 43.77 11.60 43 130114 31338 29790983
Delirium 43.72 11.60 68 130089 40563 29781758
Immunoglobulins decreased 42.77 11.60 31 130126 701 29821620
Haematemesis 42.56 11.60 31 130126 26172 29796149
Asthenia 42.54 11.60 691 129466 220599 29601722
Blood glucose increased 42.27 11.60 132 130025 61398 29760923
Graft versus host disease 42.25 11.60 118 130039 10032 29812289
Polyarthritis 42.11 11.60 61 130096 3208 29819113
Depressed level of consciousness 42.06 11.60 63 130094 38159 29784162
Blood immunoglobulin A decreased 41.97 11.60 21 130136 233 29822088
Haemophagocytic lymphohistiocytosis 41.92 11.60 115 130042 9676 29812645
Prerenal failure 41.86 11.60 46 130111 1825 29820496
Restlessness 41.84 11.60 23 130134 22576 29799745
Humoral immune defect 41.80 11.60 14 130143 47 29822274
Lymphadenitis 41.48 11.60 44 130113 1676 29820645
Melaena 41.28 11.60 48 130109 32389 29789932
Vision blurred 41.28 11.60 74 130083 41742 29780579
Disability 41.07 11.60 71 130086 4347 29817974
Chest pain 40.95 11.60 321 129836 117306 29705015
Nightmare 40.90 11.60 3 130154 12073 29810248
Osteoarthritis 40.77 11.60 173 129984 18176 29804145
Drug tolerance decreased 40.47 11.60 36 130121 1100 29821221
Pulmonary fibrosis 40.22 11.60 156 130001 15734 29806587
Joint arthroplasty 39.96 11.60 28 130129 599 29821722
Candida infection 39.86 11.60 152 130005 15210 29807111
Therapeutic product effect decreased 39.74 11.60 239 129918 28837 29793484
Psychotic disorder 39.68 11.60 22 130135 21493 29800828
Immune thrombocytopenia 39.55 11.60 96 130061 7495 29814826
Immunoglobulin G4 related disease 39.46 11.60 15 130142 79 29822242
Dysgeusia 39.43 11.60 30 130127 24771 29797550
Product prescribing error 39.11 11.60 12 130145 16721 29805600
Gamma-glutamyltransferase increased 38.92 11.60 42 130115 29308 29793013
Drug resistance 38.84 11.60 182 129975 19951 29802370
Erectile dysfunction 38.82 11.60 15 130142 18087 29804234
Epstein-Barr viraemia 38.68 11.60 32 130125 884 29821437
Asthma 38.49 11.60 61 130096 36113 29786208
Depressed mood 38.41 11.60 13 130144 17016 29805305
Hand deformity 38.40 11.60 44 130113 1829 29820492
Gastritis bacterial 38.21 11.60 18 130139 173 29822148
Blood immunoglobulin G decreased 37.96 11.60 32 130125 908 29821413
Tooth fracture 37.90 11.60 58 130099 3204 29819117
Mantle cell lymphoma refractory 37.85 11.60 15 130142 90 29822231
Pain in extremity 37.80 11.60 302 129855 109919 29712402
5q minus syndrome 37.74 11.60 17 130140 146 29822175
Therapy non-responder 37.68 11.60 238 129919 29215 29793106
Extravasation 37.57 11.60 43 130114 1785 29820536
Drug dependence 37.54 11.60 23 130134 21272 29801049
Transplant rejection 37.31 11.60 106 130051 9100 29813221
Incorrect dose administered 37.07 11.60 50 130107 31636 29790685
Therapy cessation 36.95 11.60 10 130147 15127 29807194
Haemoglobin abnormal 36.87 11.60 56 130101 3073 29819248
Orthostatic hypotension 36.87 11.60 30 130127 23949 29798372
Cerebral aspergillosis 36.83 11.60 37 130120 1321 29821000
Sweat gland tumour 36.76 11.60 23 130134 404 29821917
Arthritis bacterial 36.70 11.60 68 130089 4396 29817925
Angioedema 36.56 11.60 58 130099 34326 29787995
Sopor 36.47 11.60 3 130154 10988 29811333
Disorientation 36.33 11.60 50 130107 31368 29790953
Aspartate aminotransferase increased 36.27 11.60 147 130010 63275 29759046
Glomerulonephritis 36.17 11.60 42 130115 1771 29820550
Pseudomonas infection 36.15 11.60 114 130043 10368 29811953
Emotional distress 35.61 11.60 12 130145 15753 29806568
Neoplasm progression 35.56 11.60 164 129993 17859 29804462
Therapeutic response decreased 35.12 11.60 203 129954 24146 29798175
Liver function test abnormal 35.05 11.60 50 130107 30900 29791421
Pulmonary toxicity 34.90 11.60 67 130090 4449 29817872
Platelet count abnormal 34.86 11.60 47 130110 2310 29820011
Labelled drug-drug interaction medication error 34.62 11.60 3 130154 10535 29811786
Mental status changes 34.50 11.60 68 130089 37011 29785310
Oedema peripheral 34.46 11.60 294 129863 105538 29716783
Hip fracture 34.38 11.60 4 130153 11120 29811201
Anger 34.36 11.60 4 130153 11116 29811205
Vasculitis 34.36 11.60 94 130063 7896 29814425
Abdominal distension 34.34 11.60 94 130063 45615 29776706
Scleroderma 33.89 11.60 35 130122 1292 29821029
Bone marrow infiltration 33.52 11.60 14 130143 98 29822223
Product quality issue 33.48 11.60 20 130137 18754 29803567
Refractory anaemia with an excess of blasts 33.26 11.60 21 130136 375 29821946
Delusion 33.14 11.60 6 130151 11983 29810338
Sleep disorder due to general medical condition, insomnia type 32.97 11.60 33 130124 1173 29821148
Lymphoplasmacytoid lymphoma/immunocytoma 32.83 11.60 11 130146 37 29822284
BK virus infection 32.82 11.60 64 130093 4300 29818021
Cerebral haemorrhage 32.63 11.60 58 130099 32829 29789492
Pancreatitis 32.18 11.60 69 130088 36421 29785900
Viral haemorrhagic cystitis 32.10 11.60 28 130129 833 29821488
Congenital cardiovascular anomaly 31.86 11.60 16 130141 179 29822142
Pancreatitis acute 31.65 11.60 39 130118 25656 29796665
Acute lung injury 31.57 11.60 31 130126 1076 29821245
Adenovirus infection 31.38 11.60 62 130095 4206 29818115
Gait inability 30.98 11.60 22 130135 18819 29803502
Muscle rigidity 30.95 11.60 4 130153 10257 29812064
Wrist deformity 30.90 11.60 19 130138 323 29821998
Blood alkaline phosphatase increased 30.82 11.60 56 130101 31431 29790890
Road traffic accident 30.70 11.60 18 130139 17053 29805268
Hyperlipidaemia 30.70 11.60 11 130146 13896 29808425
Ventricular tachycardia 30.70 11.60 35 130122 23827 29798494
Periostitis 30.65 11.60 17 130140 236 29822085
Unresponsive to stimuli 30.59 11.60 42 130115 26377 29795944
Head injury 30.54 11.60 18 130139 17002 29805319
Febrile infection 30.27 11.60 37 130120 1648 29820673
Enterovirus infection 30.10 11.60 23 130134 565 29821756
Fluid retention 29.70 11.60 39 130118 24959 29797362
Neuromyelitis optica spectrum disorder 29.68 11.60 14 130143 135 29822186
Exposure during pregnancy 29.46 11.60 3 130154 9258 29813063
Faeces discoloured 29.18 11.60 12 130145 13934 29808387
Hypoaesthesia 28.97 11.60 129 130028 54101 29768220
Enterococcal infection 28.87 11.60 90 130067 8134 29814187
Pneumonia fungal 28.86 11.60 70 130087 5463 29816858
Dry skin 28.81 11.60 33 130124 22421 29799900
Hepatitis B surface antigen positive 28.53 11.60 13 130144 115 29822206
Marginal zone lymphoma 28.40 11.60 9 130148 24 29822297
Glomerulonephritis membranoproliferative 28.35 11.60 19 130138 377 29821944
Babesiosis 28.32 11.60 11 130146 62 29822259
Immunodeficiency common variable 28.16 11.60 14 130143 153 29822168
Autoimmune lymphoproliferative syndrome 28.16 11.60 14 130143 153 29822168
Post procedural complication 28.15 11.60 8 130149 11718 29810603
Microscopic polyangiitis 28.14 11.60 13 130144 119 29822202
Escherichia sepsis 28.14 11.60 57 130100 3937 29818384
Herpes simplex encephalitis 27.96 11.60 17 130140 283 29822038
Meningitis cryptococcal 27.88 11.60 39 130118 1985 29820336
Non-Hodgkin's lymphoma 27.56 11.60 36 130121 1715 29820606
Injection site swelling 27.53 11.60 3 130154 8777 29813544
Hyperglycaemia 27.49 11.60 71 130086 35129 29787192
Swelling face 27.39 11.60 31 130126 21173 29801148
Prostatic specific antigen increased 27.36 11.60 9 130148 11995 29810326
Sleep disorder 27.27 11.60 40 130117 24439 29797882
Neoplasm recurrence 27.26 11.60 37 130120 1830 29820491
Pneumonia klebsiella 27.25 11.60 44 130113 2546 29819775
Abscess 27.21 11.60 101 130056 9977 29812344
Paraneoplastic pemphigus 27.09 11.60 11 130146 71 29822250
Epstein-Barr virus associated lymphoma 27.03 11.60 21 130136 529 29821792
Human herpesvirus 8 infection 26.89 11.60 23 130134 666 29821655
Amnesia 26.84 11.60 40 130117 24281 29798040
Cryoglobulinaemia 26.81 11.60 17 130140 306 29822015
Chronic allograft nephropathy 26.66 11.60 29 130128 1137 29821184
Lip swelling 26.61 11.60 11 130146 12733 29809588
Dystonia 26.60 11.60 5 130152 9722 29812599
Adverse drug reaction 26.59 11.60 37 130120 23108 29799213
Abdominal pain upper 26.54 11.60 161 129996 62390 29759931
Rib fracture 26.52 11.60 11 130146 12709 29809612
Acute myocardial infarction 26.46 11.60 129 130028 52810 29769511
Musculoskeletal stiffness 26.40 11.60 255 129902 35626 29786695
Traumatic lung injury 26.36 11.60 29 130128 1152 29821169
Chronic graft versus host disease 25.78 11.60 56 130101 4063 29818258
Mucormycosis 25.73 11.60 65 130092 5203 29817118
Cardiac disorder 25.72 11.60 88 130069 39805 29782516
Hypertension 25.62 11.60 372 129785 120982 29701339
Headache 25.61 11.60 600 129557 181706 29640615
Atypical pneumonia 25.61 11.60 44 130113 2680 29819641
Thrombotic microangiopathy 25.55 11.60 89 130068 8521 29813800
Pneumonia adenoviral 25.54 11.60 13 130144 150 29822171
Splenic marginal zone lymphoma 25.47 11.60 9 130148 37 29822284
Osteonecrosis of jaw 25.40 11.60 26 130131 18592 29803729
West Nile viral infection 25.39 11.60 21 130136 580 29821741
Medical device implantation 25.37 11.60 20 130137 515 29821806
Bacterial sepsis 25.35 11.60 62 130095 4864 29817457
Pneumonia escherichia 25.34 11.60 17 130140 338 29821983
Chronic lymphocytic leukaemia transformation 25.33 11.60 14 130143 193 29822128
Psychomotor hyperactivity 25.31 11.60 3 130154 8221 29814100
Colitis 25.17 11.60 224 129933 30596 29791725
Herpes virus infection 25.12 11.60 42 130115 2502 29819819
Peritonitis bacterial 25.12 11.60 9 130148 11369 29810952
Pseudomonal sepsis 25.04 11.60 46 130111 2954 29819367
Intestinal obstruction 24.91 11.60 28 130129 19184 29803137
Device malfunction 24.86 11.60 3 130154 8108 29814213
Disturbance in attention 24.80 11.60 36 130121 22093 29800228
Hypokalaemia 24.69 11.60 123 130034 50069 29772252
Bacteraemia 24.61 11.60 133 130024 15427 29806894
Dyspnoea 24.60 11.60 1191 128966 332104 29490217
Pneumonia aspiration 24.59 11.60 83 130074 37697 29784624
Blood pressure systolic increased 24.47 11.60 130 130027 14980 29807341
Erysipelas 24.42 11.60 58 130099 4466 29817855
CD4 lymphocytes decreased 24.33 11.60 37 130120 2033 29820288
Prescribed overdose 24.29 11.60 4 130153 8557 29813764
Encephalitis viral 24.28 11.60 28 130129 1172 29821149
Nasal cavity cancer 24.07 11.60 12 130145 132 29822189
Skin discolouration 23.98 11.60 20 130137 15774 29806547
Flatulence 23.97 11.60 26 130131 18103 29804218
Cellulitis gangrenous 23.86 11.60 13 130144 174 29822147
Temperature intolerance 23.85 11.60 45 130112 2950 29819371
COVID-19 23.82 11.60 146 130011 17732 29804589
Haematochezia 23.79 11.60 73 130084 34149 29788172
Hypocalcaemia 23.74 11.60 35 130122 21341 29800980
Fluoride increased 23.74 11.60 9 130148 47 29822274
Cytomegalovirus test positive 23.32 11.60 50 130107 3595 29818726
Stomatitis 23.18 11.60 256 129901 37023 29785298
Blood glucose decreased 23.14 11.60 14 130143 13039 29809282
Graft versus host disease in skin 23.07 11.60 47 130110 3260 29819061
Blood potassium decreased 23.04 11.60 23 130134 16639 29805682
Human herpesvirus 6 infection 23.01 11.60 35 130122 1923 29820398
Underdose 23.00 11.60 12 130145 12129 29810192
Prothrombin time prolonged 22.98 11.60 6 130151 9297 29813024
Cystitis escherichia 22.98 11.60 13 130144 188 29822133
Hallucination, auditory 22.91 11.60 7 130150 9782 29812539
Lung disorder 22.83 11.60 223 129934 31246 29791075
Diaphragm muscle weakness 22.81 11.60 10 130147 80 29822241
Hypercholesterolaemia 22.80 11.60 3 130154 7589 29814732
Blood immunoglobulin M increased 22.80 11.60 13 130144 191 29822130
Cytomegalovirus gastritis 22.74 11.60 13 130144 192 29822129
Haemolytic anaemia 22.72 11.60 95 130062 9915 29812406
Intestinal perforation 22.68 11.60 85 130072 8434 29813887
Psoriatic arthropathy 22.67 11.60 21 130136 15740 29806581
Balance disorder 22.52 11.60 82 130075 36411 29785910
Cardiomegaly 22.49 11.60 18 130139 14491 29807830
Burning sensation 22.48 11.60 23 130134 16451 29805870
Rhinovirus infection 22.43 11.60 43 130114 2852 29819469
Small intestinal perforation 22.32 11.60 32 130125 1667 29820654
Neuroborreliosis 22.27 11.60 7 130150 18 29822303
Chylothorax 22.24 11.60 20 130137 620 29821701
Human rhinovirus test positive 21.93 11.60 12 130145 162 29822159
Device related thrombosis 21.86 11.60 22 130135 787 29821534
Glycosylated haemoglobin increased 21.83 11.60 7 130150 9484 29812837
Hepatitis fulminant 21.78 11.60 51 130106 3890 29818431
Chromaturia 21.75 11.60 17 130140 13848 29808473
Bone marrow reticulin fibrosis 21.74 11.60 12 130145 165 29822156
Incorrect route of product administration 21.70 11.60 11 130146 11304 29811017
Acquired C1 inhibitor deficiency 21.61 11.60 6 130151 8 29822313
Tumour flare 21.49 11.60 18 130139 506 29821815
Hip arthroplasty 21.33 11.60 49 130108 3691 29818630
Encephalitis 21.29 11.60 69 130088 6367 29815954
Alanine aminotransferase increased 21.28 11.60 213 129944 74063 29748258
Miosis 21.26 11.60 4 130153 7772 29814549
Neurological decompensation 21.10 11.60 37 130120 2291 29820030
Abdominal lymphadenopathy 21.05 11.60 18 130139 521 29821800
Pneumonia viral 21.04 11.60 40 130117 2637 29819684
Secondary immunodeficiency 21.01 11.60 15 130142 331 29821990
Neutropenic infection 20.78 11.60 24 130133 1006 29821315
Morphoea 20.67 11.60 11 130146 140 29822181
Infusion site discolouration 20.63 11.60 10 130147 103 29822218
Blood immunoglobulin M decreased 20.63 11.60 16 130141 402 29821919
Epistaxis 20.62 11.60 140 130017 52841 29769480
Infection reactivation 20.60 11.60 23 130134 929 29821392
Escherichia infection 20.58 11.60 68 130089 6337 29815984
Postural tremor 20.54 11.60 14 130143 286 29822035
Limb deformity 20.54 11.60 17 130140 470 29821851
Intestinal atresia 20.53 11.60 9 130148 72 29822249
Hypophagia 20.49 11.60 41 130116 22195 29800126
Epstein-Barr virus associated lymphoproliferative disorder 20.47 11.60 31 130126 1697 29820624
Paraesthesia 20.43 11.60 145 130012 54182 29768139
Nervousness 20.40 11.60 13 130144 11775 29810546
Blood stem cell transplant failure 20.39 11.60 16 130141 409 29821912
Thirst 20.27 11.60 3 130154 6946 29815375
Noninfectious myelitis 20.12 11.60 6 130151 12 29822309
Antineutrophil cytoplasmic antibody increased 20.12 11.60 6 130151 12 29822309
Jejunal perforation 20.04 11.60 12 130145 194 29822127
Marginal zone lymphoma recurrent 19.96 11.60 7 130150 28 29822293
T-lymphocyte count decreased 19.88 11.60 12 130145 197 29822124
Vocal cord paralysis 19.88 11.60 21 130136 796 29821525
Generalised tonic-clonic seizure 19.83 11.60 34 130123 19517 29802804
Hairy cell leukaemia 19.81 11.60 9 130148 79 29822242
Mitral valve incompetence 19.80 11.60 17 130140 13217 29809104
Gene mutation 19.79 11.60 21 130136 800 29821521
Non-Hodgkin's lymphoma recurrent 19.76 11.60 7 130150 29 29822292
Hepatic infection fungal 19.75 11.60 11 130146 154 29822167
Pulmonary sarcoidosis 19.75 11.60 18 130139 568 29821753
Therapeutic response unexpected 19.72 11.60 7 130150 8896 29813425
High-grade B-cell lymphoma 19.69 11.60 11 130146 155 29822166
Frequent bowel movements 19.69 11.60 6 130151 8399 29813922
Oedema 19.66 11.60 108 130049 42885 29779436
Chronic kidney disease 19.61 11.60 91 130066 37747 29784574
Transient ischaemic attack 19.55 11.60 51 130106 25149 29797172
Dry mouth 19.49 11.60 44 130113 22806 29799515
Contusion 19.49 11.60 70 130087 31210 29791111
Cytomegalovirus viraemia 19.47 11.60 62 130095 5667 29816654
Gastric stenosis 19.39 11.60 7 130150 31 29822290
Rectal haemorrhage 19.33 11.60 82 130075 34857 29787464
Atrial septal defect 19.30 11.60 3 130154 6698 29815623
Neuropathy peripheral 19.28 11.60 421 129736 70054 29752267
Abdominal pain 19.16 11.60 446 129711 135208 29687113
Neurofibrosarcoma 19.04 11.60 7 130150 33 29822288
Paresis 19.03 11.60 31 130126 1807 29820514
Blood pressure diastolic increased 19.01 11.60 39 130118 2719 29819602
Urinary retention 19.00 11.60 76 130081 32841 29789480
Isosporiasis 18.88 11.60 9 130148 89 29822232
Hypersomnia 18.88 11.60 13 130144 11303 29811018
Encephalitis cytomegalovirus 18.77 11.60 15 130142 394 29821927
Adenocarcinoma gastric 18.64 11.60 24 130133 1127 29821194
Neoplasm malignant 18.63 11.60 137 130020 17677 29804644
Systemic infection 18.62 11.60 19 130138 691 29821630
Myocardial ischaemia 18.61 11.60 29 130128 17288 29805033
Salivary hypersecretion 18.46 11.60 5 130152 7561 29814760
Diffuse large B-cell lymphoma stage IV 18.45 11.60 12 130145 226 29822095
Organising pneumonia 18.25 11.60 56 130101 5018 29817303
Nervous system disorder 18.22 11.60 108 130049 12961 29809360
Encephalitis Japanese B 18.18 11.60 6 130151 19 29822302
Respiratory depression 18.17 11.60 14 130143 11489 29810832
Diabetes mellitus 18.15 11.60 107 130050 41758 29780563
Neutrophil Pelger-Huet anomaly present 18.00 11.60 12 130145 236 29822085
Cytomegalovirus oesophagitis 17.96 11.60 12 130145 237 29822084
Splenomegaly 17.90 11.60 110 130047 13370 29808951
Metastases to bone marrow 17.87 11.60 16 130141 493 29821828
Ear pruritus 17.87 11.60 12 130145 239 29822082
Adenoviral haemorrhagic cystitis 17.81 11.60 15 130142 425 29821896
Hairy cell leukaemia recurrent 17.77 11.60 4 130153 0 29822321
Glomerulonephritis rapidly progressive 17.75 11.60 15 130142 427 29821894
Hepatic amoebiasis 17.73 11.60 8 130149 69 29822252
Hypomagnesaemia 17.64 11.60 28 130129 16570 29805751
Procalcitonin increased 17.62 11.60 23 130134 1095 29821226
Blood sodium decreased 17.57 11.60 26 130131 15830 29806491
Hepatitis D 17.53 11.60 7 130150 43 29822278
Product administration error 17.52 11.60 22 130135 14355 29807966
Superior mesenteric artery syndrome 17.44 11.60 8 130149 72 29822249
Feeling abnormal 17.43 11.60 160 129997 56596 29765725
Mania 17.41 11.60 9 130148 9145 29813176
Respiratory failure 17.37 11.60 566 129591 100076 29722245
White blood cell count abnormal 17.36 11.60 37 130120 2649 29819672
Hypotension 17.36 11.60 704 129453 199861 29622460
Device related infection 17.31 11.60 130 130027 16885 29805436
Dermatitis exfoliative generalised 17.31 11.60 38 130119 2777 29819544
Central nervous system enteroviral infection 17.26 11.60 7 130150 45 29822276
Rheumatoid factor 17.25 11.60 8 130149 74 29822247
Tricuspid valve incompetence 17.12 11.60 8 130149 8615 29813706
Central nervous system fungal infection 17.12 11.60 12 130145 257 29822064
Sensitivity to weather change 17.10 11.60 26 130131 1428 29820893
Pleural effusion 17.05 11.60 432 129725 73634 29748687
Cystitis viral 17.04 11.60 15 130142 452 29821869
Throat irritation 17.02 11.60 78 130079 8470 29813851
Antineutrophil cytoplasmic antibody positive 16.98 11.60 15 130142 454 29821867
Nephrotic syndrome 16.94 11.60 67 130090 6818 29815503
Peripheral coldness 16.74 11.60 4 130153 6579 29815742
Prostatic abscess 16.73 11.60 14 130143 393 29821928
Inappropriate antidiuretic hormone secretion 16.69 11.60 15 130142 11407 29810914
Tenderness 16.66 11.60 59 130098 5696 29816625
Granuloma skin 16.61 11.60 12 130145 270 29822051
Dysarthria 16.60 11.60 72 130085 30418 29791903
Poisoning 16.57 11.60 15 130142 11367 29810954
Speech disorder 16.53 11.60 53 130104 24459 29797862
Cerebral infarction 16.44 11.60 59 130098 26314 29796007
Transformation to acute myeloid leukaemia 16.43 11.60 17 130140 629 29821692
Haematocrit decreased 16.40 11.60 73 130084 30626 29791695
Accidental exposure to product 16.38 11.60 12 130145 10103 29812218
Human polyomavirus infection 16.34 11.60 17 130140 633 29821688
Disseminated cytomegaloviral infection 16.27 11.60 10 130147 170 29822151
Granulocytopenia neonatal 16.20 11.60 6 130151 29 29822292
Primary mediastinal large B-cell lymphoma 16.15 11.60 5 130152 12 29822309
B-lymphocyte count increased 16.15 11.60 5 130152 12 29822309
Klebsiella infection 16.13 11.60 66 130091 6821 29815500
Lymphoproliferative disorder 16.12 11.60 33 130124 2297 29820024
Systemic mycosis 16.11 11.60 23 130134 1193 29821128
Varicella 16.11 11.60 26 130131 1504 29820817
Oropharyngeal squamous cell carcinoma 16.04 11.60 9 130148 128 29822193
Upper gastrointestinal haemorrhage 16.02 11.60 46 130111 21982 29800339
Cytomegalovirus enterocolitis 16.00 11.60 19 130138 821 29821500
Strongyloidiasis 15.96 11.60 33 130124 2313 29820008
Arteriosclerosis coronary artery 15.95 11.60 15 130142 11161 29811160
Device issue 15.91 11.60 7 130150 7809 29814512
Coronary artery occlusion 15.89 11.60 15 130142 11142 29811179
Gastrosplenic fistula 15.88 11.60 6 130151 31 29822290
Heart rate decreased 15.83 11.60 150 130007 20844 29801477
Empyema 15.83 11.60 37 130120 2819 29819502
Eating disorder 15.77 11.60 5 130152 6822 29815499
Mucocutaneous haemorrhage 15.74 11.60 8 130149 92 29822229
Ureteric compression 15.72 11.60 6 130151 32 29822289
Back pain 15.71 11.60 333 129824 102263 29720058
Ischaemic cardiomyopathy 15.67 11.60 4 130153 6293 29816028
Stiff person syndrome 15.62 11.60 9 130148 135 29822186
Impaired work ability 15.61 11.60 57 130100 5586 29816735
Myoclonus 15.57 11.60 21 130136 13291 29809030
Bacterial infection 15.57 11.60 101 130056 12509 29809812
Mantle cell lymphoma stage IV 15.55 11.60 7 130150 60 29822261
Respiratory tract infection 15.51 11.60 118 130039 15388 29806933
Lung adenocarcinoma 15.46 11.60 46 130111 4053 29818268
Bone disorder 15.46 11.60 5 130152 6736 29815585
Acute respiratory distress syndrome 15.43 11.60 163 129994 23309 29799012
Cutaneous T-cell lymphoma recurrent 15.42 11.60 6 130151 34 29822287
Gallbladder adenocarcinoma 15.35 11.60 5 130152 15 29822306
Coxsackie viral infection 15.35 11.60 5 130152 15 29822306
Hyperthyroidism 15.34 11.60 8 130149 8090 29814231
Ageusia 15.32 11.60 10 130147 8943 29813378
Retroperitoneal lymphadenopathy 15.32 11.60 17 130140 682 29821639
COVID-19 pneumonia 15.31 11.60 49 130108 4491 29817830
Lymphocyte count decreased 15.30 11.60 138 130019 18917 29803404
Visual impairment 15.30 11.60 74 130083 30364 29791957
Crystal nephropathy 15.30 11.60 13 130144 373 29821948
Acute myelomonocytic leukaemia 15.22 11.60 9 130148 142 29822179
Cardiotoxicity 15.21 11.60 48 130109 4366 29817955
Viral cardiomyopathy 15.14 11.60 6 130151 36 29822285
Dysstasia 15.11 11.60 14 130143 10491 29811830
Mydriasis 15.10 11.60 4 130153 6139 29816182
Blood creatinine increased 15.06 11.60 293 129864 91082 29731239
Neck pain 15.04 11.60 44 130113 20900 29801421
Malignant transformation 15.04 11.60 17 130140 696 29821625
Mental impairment 15.03 11.60 11 130146 9266 29813055
Positron emission tomogram abnormal 15.02 11.60 8 130149 102 29822219
Aplasia 14.94 11.60 45 130112 3992 29818329
Atypical fibroxanthoma 14.90 11.60 10 130147 199 29822122
Phlebitis infective 14.85 11.60 9 130148 149 29822172
Nasal congestion 14.84 11.60 37 130120 18529 29803792
Tooth infection 14.84 11.60 53 130104 5138 29817183
Pulmonary vasculitis 14.80 11.60 7 130150 68 29822253
Pulmonary congestion 14.77 11.60 19 130138 12268 29810053
Sudden death 14.76 11.60 28 130129 15464 29806857
Castleman's disease 14.74 11.60 6 130151 39 29822282
Metastases to muscle 14.73 11.60 10 130147 203 29822118
Prostate cancer 14.65 11.60 164 129993 23793 29798528
Anorectal varices 14.61 11.60 6 130151 40 29822281
Polymyositis 14.57 11.60 24 130133 1412 29820909
Urticaria 14.55 11.60 325 129832 54281 29768040
Central nervous system infection 14.54 11.60 14 130143 474 29821847
Haemorrhage 14.54 11.60 129 130028 45950 29776371
Metastases to retroperitoneum 14.52 11.60 10 130147 208 29822113
Cytomegalovirus colitis 14.50 11.60 32 130125 2347 29819974
Skin infection 14.49 11.60 59 130098 6085 29816236
Rheumatoid factor increased 14.47 11.60 14 130143 477 29821844
Full blood count decreased 14.46 11.60 29 130128 15688 29806633
Presyncope 14.46 11.60 30 130127 16026 29806295
Mood altered 14.41 11.60 9 130148 8241 29814080
Abdominal wall abscess 14.38 11.60 14 130143 481 29821840
Swollen tongue 14.26 11.60 22 130135 13170 29809151
Helicobacter sepsis 14.26 11.60 5 130152 20 29822301
Ecthyma 14.25 11.60 12 130145 340 29821981
Borrelia infection 14.24 11.60 6 130151 43 29822278
Iron deficiency anaemia 14.23 11.60 11 130146 9013 29813308
Nocardiosis 14.21 11.60 40 130117 3415 29818906
Altered state of consciousness 14.19 11.60 42 130115 19877 29802444
Cytokine storm 14.19 11.60 15 130142 569 29821752
Acute lymphocytic leukaemia recurrent 14.19 11.60 34 130123 2633 29819688
Follicle centre lymphoma, follicular grade I, II, III recurrent 14.13 11.60 4 130153 6 29822315
Suspected product quality issue 14.05 11.60 9 130148 165 29822156
Thinking abnormal 13.96 11.60 3 130154 5308 29817013
Sphingomonas paucimobilis infection 13.90 11.60 6 130151 46 29822275
Phlebitis 13.89 11.60 42 130115 3733 29818588
Glottis carcinoma 13.88 11.60 5 130152 22 29822299
Infective thrombosis 13.81 11.60 7 130150 80 29822241
Recurrent cancer 13.79 11.60 21 130136 1155 29821166
Blood loss anaemia 13.77 11.60 8 130149 7619 29814702
Chronic obstructive pulmonary disease 13.74 11.60 131 130026 45995 29776326
Right ventricular failure 13.72 11.60 9 130148 8027 29814294
Myeloid leukaemia 13.70 11.60 12 130145 359 29821962
Blood bilirubin increased 13.67 11.60 98 130059 36538 29785783
Multiple organ dysfunction syndrome 13.65 11.60 367 129790 63120 29759201
Blood triglycerides increased 13.65 11.60 25 130132 13992 29808329
Hepatitis B DNULL increased 13.64 11.60 14 130143 513 29821808
Dyslipidaemia 13.58 11.60 4 130153 5723 29816598
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 13.41 11.60 4 130153 8 29822313
Pulmonary mass 13.41 11.60 87 130070 10775 29811546
Haematoma 13.38 11.60 56 130101 23897 29798424
Lacrimal duct neoplasm 13.37 11.60 5 130152 25 29822296
Viral myelitis 13.37 11.60 5 130152 25 29822296
Mantle cell lymphoma stage III 13.37 11.60 5 130152 25 29822296
Hypoglobulinaemia 13.33 11.60 3 130154 0 29822321
Human anti-mouse antibody positive 13.33 11.60 3 130154 0 29822321
Necrotising soft tissue infection 13.27 11.60 6 130151 52 29822269
Device occlusion 13.24 11.60 5 130152 6115 29816206
Intraocular pressure increased 13.24 11.60 3 130154 5117 29817204
Dialysis 13.22 11.60 17 130140 10979 29811342
Injection site erythema 13.19 11.60 25 130132 13809 29808512
Increased appetite 13.18 11.60 4 130153 5613 29816708
Dyspnoea exertional 13.11 11.60 95 130062 35335 29786986
Ureaplasma infection 13.03 11.60 9 130148 188 29822133
Colitis ulcerative 12.97 11.60 27 130130 14407 29807914
Tularaemia 12.96 11.60 7 130150 92 29822229
Central nervous system vasculitis 12.95 11.60 12 130145 387 29821934
Guillain-Barre syndrome 12.94 11.60 50 130107 5033 29817288
Gonococcal infection 12.90 11.60 5 130152 28 29822293
Cerebral toxoplasmosis 12.83 11.60 23 130134 1449 29820872
Hyperammonaemia 12.82 11.60 4 130153 5516 29816805
Bone marrow necrosis 12.81 11.60 8 130149 140 29822181
Photosensitivity reaction 12.81 11.60 79 130078 9615 29812706
Basophilia 12.80 11.60 4 130153 10 29822311
Lung adenocarcinoma stage I 12.80 11.60 4 130153 10 29822311
Back disorder 12.80 11.60 5 130152 5989 29816332
Cholelithiasis 12.77 11.60 45 130112 20180 29802141
Neutrophil percentage decreased 12.77 11.60 12 130145 394 29821927
Venoocclusive disease 12.70 11.60 32 130125 2558 29819763
Alveolitis 12.69 11.60 25 130132 1692 29820629
Blood bilirubin decreased 12.63 11.60 10 130147 259 29822062
Evans syndrome 12.60 11.60 10 130147 260 29822061
Choking 12.59 11.60 3 130154 4943 29817378
Hemianopia 12.58 11.60 15 130142 651 29821670
Chronic lymphocytic leukaemia stage 2 12.53 11.60 4 130153 11 29822310
Blood pressure increased 12.53 11.60 405 129752 71523 29750798
Lymph node palpable 12.48 11.60 5 130152 31 29822290
Metastases to spleen 12.48 11.60 11 130146 332 29821989
Drug eruption 12.45 11.60 37 130120 17489 29804832
Bronchopneumopathy 12.45 11.60 12 130145 407 29821914
Infected neoplasm 12.45 11.60 6 130151 61 29822260
Ventricular hypertrophy 12.37 11.60 3 130154 4884 29817437
Refractory cytopenia with multilineage dysplasia 12.33 11.60 8 130149 150 29822171
Heparin-induced thrombocytopenia 12.33 11.60 4 130153 5379 29816942
Staphylococcal sepsis 12.32 11.60 77 130080 9414 29812907
Diffuse large B-cell lymphoma stage III 12.28 11.60 6 130151 63 29822258
Musculoskeletal discomfort 12.27 11.60 6 130151 6294 29816027
Alopecia 12.27 11.60 133 130024 19142 29803179
Fungal infection 12.23 11.60 101 130056 13499 29808822
Pruritus 12.21 11.60 406 129751 117798 29704523
Left ventricular hypertrophy 12.20 11.60 6 130151 6272 29816049
Gynaecomastia 12.16 11.60 11 130146 8340 29813981
Drug level increased 12.16 11.60 40 130117 18314 29804007
Acute hepatitis B 12.15 11.60 7 130150 105 29822216
Nervous system neoplasm 12.15 11.60 8 130149 154 29822167
Drug level decreased 12.14 11.60 5 130152 5800 29816521
Leukaemic infiltration 12.12 11.60 6 130151 65 29822256
Cystitis haemorrhagic 12.12 11.60 47 130110 4740 29817581
X-ray abnormal 11.99 11.60 13 130144 508 29821813
Autoimmune neutropenia 11.94 11.60 10 130147 281 29822040
Squamous cell carcinoma of skin 11.94 11.60 74 130083 9021 29813300
Blood cholesterol increased 11.93 11.60 36 130121 16934 29805387
Schizophrenia 11.93 11.60 13 130144 9035 29813286
Adverse event 11.93 11.60 31 130126 15310 29807011
Myelitis transverse 11.93 11.60 18 130139 982 29821339
Meningoencephalitis viral 11.92 11.60 7 130150 109 29822212
Rebound effect 11.87 11.60 23 130134 1538 29820783
Neoplasm 11.86 11.60 42 130115 4054 29818267
Shock 11.83 11.60 55 130102 22804 29799517
Encephalitis autoimmune 11.82 11.60 12 130145 434 29821887
B-lymphocyte abnormalities 11.82 11.60 4 130153 14 29822307
Pollakiuria 11.79 11.60 36 130121 16870 29805451
Activated partial thromboplastin time prolonged 11.78 11.60 10 130147 7818 29814503
Myelofibrosis 11.77 11.60 23 130134 1548 29820773
Pneumonia respiratory syncytial viral 11.75 11.60 14 130143 607 29821714
Volvulus of small bowel 11.74 11.60 5 130152 37 29822284
Dermatitis acneiform 11.73 11.60 5 130152 5684 29816637
Foetal exposure during pregnancy 11.73 11.60 103 130054 36768 29785553
Aplasia pure red cell 11.70 11.60 52 130105 5574 29816747
Blood lactate dehydrogenase increased 11.69 11.60 139 130018 20462 29801859
Blood potassium increased 11.69 11.60 34 130123 16179 29806142
Haemoptysis 11.66 11.60 83 130074 30995 29791326
Hepatosplenomegaly 11.63 11.60 39 130118 3662 29818659
Phaeohyphomycosis 11.63 11.60 16 130141 802 29821519
Obesity 11.61 11.60 12 130145 8543 29813778
Reflux laryngitis 11.61 11.60 4 130153 15 29822306
Palmar-plantar erythrodysaesthesia syndrome 11.60 11.60 30 130127 14840 29807481

Pharmacologic Action:

SourceCodeDescription
ATC L01XC02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Monoclonal antibodies
FDA MoA N0000175078 CD20-directed Antibody Interactions
FDA EPC N0000175657 CD20-directed Cytolytic Antibody
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Chronic lymphoid leukemia, disease indication 92814006
Non-Hodgkin's lymphoma indication 118601006
Wegener's granulomatosis indication 195353004 DOID:12132
Microscopic polyarteritis nodosa indication 239928004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
B-lymphocyte antigen CD20 Surface antigen ANTIBODY BINDING Kd 8.51 IUPHAR DRUG LABEL

External reference:

IDSource
D02994 KEGG_DRUG
4021104 VUID
N0000148560 NUI
4021104 VANDF
C1314901 UMLSCUI
CHEMBL1201576 ChEMBL_ID
D000069283 MESH_DESCRIPTOR_UI
6780 IUPHAR_LIGAND_ID
7609 INN_ID
DB00073 DRUGBANK_ID
4F4X42SYQ6 UNII
121191 RXNORM
11468 MMSL
5432 MMSL
d04255 MMSL
007236 NDDF
108809004 SNOMEDCT_US
386919002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0238 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0249 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 30 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-108 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 28 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-109 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 28 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-224 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 31 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-326 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 31 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-103 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-104 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections