rituximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4975 174722-31-7

Description:

MoleculeDescription

Synonyms:

  • rituximab
  • rituxan
  • MabThera
  • rituximab (genetical recombination)
A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 25, 2008 PMDA Bayer Yakuhin, Nihon Schering, Zenyaku Kogyo
Nov. 26, 1997 FDA GENENTECH
June 2, 1998 EMA Roche Registration GmbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 3280.59 11.31 12153 316373 807180 49469418
Contraindicated product administered 2691.90 11.31 4022 324504 144936 50131662
Drug intolerance 2259.45 11.31 4619 323907 214485 50062113
Treatment failure 2089.89 11.31 3432 325094 134205 50142393
Infusion related reaction 1924.88 11.31 3723 324803 165834 50110764
Pemphigus 1865.11 11.31 3027 325499 117139 50159459
Systemic lupus erythematosus 1749.73 11.31 3212 325314 137410 50139188
Glossodynia 1430.80 11.31 2635 325891 112934 50163664
Off label use 1421.09 11.31 6458 322068 467968 49808630
Synovitis 1343.66 11.31 2670 325856 121195 50155403
Joint swelling 1333.20 11.31 4051 324475 241235 50035363
Hand deformity 1323.36 11.31 2350 326176 97849 50178749
Arthropathy 1250.34 11.31 2998 325528 154908 50121690
Intentional product use issue 1145.35 11.31 1903 326623 75015 50201583
Alopecia 1135.36 11.31 3832 324694 241215 50035383
Abdominal discomfort 1134.29 11.31 3691 324835 227950 50048648
Therapeutic product effect decreased 993.61 11.31 2505 326021 133545 50143053
Rheumatoid arthritis 925.48 11.31 3154 325372 199396 50077202
Swelling 890.75 11.31 3097 325429 197775 50078823
Wound 864.99 11.31 2035 326491 103759 50172839
Anti-cyclic citrullinated peptide antibody positive 849.54 11.31 1591 326935 68996 50207602
Progressive multifocal leukoencephalopathy 825.29 11.31 646 327880 10811 50265787
Completed suicide 816.67 11.31 7 328519 131882 50144716
Hepatic enzyme increased 758.63 11.31 2284 326242 135096 50141502
Product dose omission issue 734.03 11.31 150 328376 183688 50092910
Rheumatoid factor positive 728.98 11.31 1224 327302 48635 50227963
Pericarditis 690.71 11.31 1557 326969 77132 50199466
Drug interaction 652.91 11.31 240 328286 199381 50077217
Discomfort 568.21 11.31 1770 326756 106610 50169988
Toxicity to various agents 563.59 11.31 341 328185 212158 50064440
Hypogammaglobulinaemia 554.00 11.31 385 328141 5314 50271284
Infection 550.72 11.31 2403 326123 170551 50106047
Fall 530.57 11.31 848 327678 334084 49942514
Product use issue 528.91 11.31 2145 326381 147330 50129268
Pain 517.58 11.31 5881 322645 573022 49703576
Hypersensitivity 515.21 11.31 2754 325772 212407 50064191
Maternal exposure during pregnancy 512.47 11.31 2225 326301 157553 50119045
Dizziness 498.42 11.31 932 327594 345437 49931161
Injection site pain 490.52 11.31 69 328457 110955 50165643
Musculoskeletal stiffness 473.05 11.31 1867 326659 126614 50149984
Helicobacter infection 424.28 11.31 973 327553 48729 50227869
Diffuse large B-cell lymphoma recurrent 408.52 11.31 202 328324 1393 50275205
Febrile neutropenia 400.38 11.31 1469 327057 96198 50180400
Anxiety 396.37 11.31 342 328184 177264 50099334
Duodenal ulcer perforation 390.51 11.31 894 327632 44717 50231881
Vomiting 384.35 11.31 1614 326912 459144 49817454
Diarrhoea 381.90 11.31 2252 326274 586224 49690374
Drug abuse 371.15 11.31 3 328523 59843 50216755
Red blood cell sedimentation rate increased 369.85 11.31 676 327850 28740 50247858
Overdose 344.67 11.31 109 328417 99618 50176980
Acute kidney injury 332.59 11.31 608 327918 227450 50049148
Feeling abnormal 327.40 11.31 205 328321 125287 50151311
Loss of personal independence in daily activities 320.84 11.31 1093 327433 68957 50207641
Rash 319.85 11.31 4283 324243 433188 49843410
Arthralgia 313.71 11.31 4278 324248 434424 49842174
Constipation 297.49 11.31 466 328060 185242 50091356
Product use in unapproved indication 291.47 11.31 1504 327022 114315 50162283
Oedema peripheral 272.87 11.31 376 328150 157585 50119013
Dehydration 271.33 11.31 355 328171 152094 50124504
Cardiac failure congestive 271.31 11.31 104 328422 84278 50192320
C-reactive protein increased 259.08 11.31 984 327542 65490 50211108
Muscle spasms 252.80 11.31 265 328261 125288 50151310
Drug hypersensitivity 252.36 11.31 2614 325912 248396 50028202
Dyspnoea 249.80 11.31 2314 326212 545294 49731304
Rheumatoid nodule 246.55 11.31 356 328170 12379 50264219
Hip arthroplasty 244.63 11.31 582 327944 29847 50246751
Tremor 242.22 11.31 233 328293 114670 50161928
Hyponatraemia 241.27 11.31 164 328362 95975 50180623
Suicide attempt 240.93 11.31 27 328499 51705 50224893
Injection site erythema 239.84 11.31 93 328433 74843 50201755
C-reactive protein abnormal 228.01 11.31 536 327990 27273 50249325
Ill-defined disorder 226.28 11.31 825 327701 53829 50222769
Seizure 224.95 11.31 260 328266 117614 50158984
Wrong technique in product usage process 223.99 11.31 44 328482 55466 50221132
Blood pressure diastolic abnormal 217.83 11.31 286 328240 9075 50267523
Panniculitis 212.29 11.31 269 328257 8234 50268364
Depressed level of consciousness 210.01 11.31 41 328485 51912 50224686
Rhabdomyolysis 207.95 11.31 11 328515 39016 50237582
Myalgia 205.66 11.31 305 328221 124014 50152584
Somnolence 205.21 11.31 437 328089 154548 50122050
Bone erosion 205.11 11.31 312 328214 11375 50265223
Asthenia 202.89 11.31 1227 327299 317815 49958783
Suicidal ideation 201.43 11.31 55 328471 55330 50221268
Hypoglycaemia 200.99 11.31 50 328476 53531 50223067
Granuloma skin 200.22 11.31 217 328309 5601 50270997
Death 199.85 11.31 1265 327261 324114 49952484
Nausea 199.70 11.31 3303 325223 702095 49574503
Blood parathyroid hormone decreased 198.48 11.31 238 328288 6876 50269722
Hospitalisation 197.32 11.31 97 328429 67840 50208758
Blood pressure fluctuation 189.24 11.31 587 327939 35236 50241362
Bradycardia 188.62 11.31 91 328435 64335 50212263
International normalised ratio increased 185.47 11.31 29 328497 43123 50233475
Neutropenia 184.27 11.31 1613 326913 146352 50130246
Knee arthroplasty 182.57 11.31 580 327946 35266 50241332
Blood pressure systolic abnormal 181.73 11.31 237 328289 7469 50269129
Throat irritation 181.07 11.31 518 328008 29721 50246877
B-lymphocyte count decreased 180.37 11.31 97 328429 813 50275785
Cardiac arrest 179.34 11.31 167 328359 83484 50193114
Inappropriate schedule of product administration 178.25 11.31 124 328402 71707 50204891
Vision blurred 175.81 11.31 151 328375 78496 50198102
Cardio-respiratory arrest 175.58 11.31 65 328461 53827 50222771
Therapeutic product effect incomplete 173.96 11.31 1103 327423 90412 50186186
Agitation 172.90 11.31 65 328461 53319 50223279
Drug tolerance decreased 172.86 11.31 253 328273 8907 50267691
Incorrect dose administered 170.66 11.31 51 328475 48363 50228235
Injection site pruritus 169.56 11.31 29 328497 40382 50236216
Decreased appetite 169.26 11.31 700 327826 200223 50076375
Electrocardiogram QT prolonged 168.34 11.31 63 328463 51823 50224775
Abdominal pain 168.25 11.31 875 327651 235353 50041245
Pulmonary fibrosis 167.61 11.31 440 328086 23997 50252601
Blood cholesterol increased 167.60 11.31 757 327769 54458 50222140
Inflammation 165.14 11.31 770 327756 56142 50220456
Hyperkalaemia 161.80 11.31 55 328471 48034 50228564
Gastrooesophageal reflux disease 159.84 11.31 156 328370 76272 50200326
Intentional product misuse 159.77 11.31 52 328474 46682 50229916
Cytomegalovirus infection 156.92 11.31 355 328171 17607 50258991
Injection site swelling 156.64 11.31 39 328487 41734 50234864
Rheumatic fever 155.94 11.31 341 328185 16526 50260072
Hepatitis B 155.19 11.31 149 328377 3317 50273281
Hepatitis B reactivation 153.13 11.31 119 328407 1968 50274630
Pneumocystis jirovecii pneumonia 152.46 11.31 311 328215 14352 50262246
No adverse event 151.96 11.31 522 328004 33056 50243542
Swollen joint count increased 151.74 11.31 313 328213 14560 50262038
Diffuse large B-cell lymphoma refractory 149.39 11.31 90 328436 956 50275642
Cerebrovascular accident 149.17 11.31 240 328286 94440 50182158
Skin necrosis 148.44 11.31 259 328267 10608 50265990
Multiple sclerosis relapse 148.31 11.31 47 328479 42917 50233681
Myocardial infarction 146.63 11.31 219 328307 88808 50187790
Malaise 144.35 11.31 1437 327089 334095 49942503
Urinary tract infection 144.11 11.31 858 327668 223162 50053436
Product quality issue 143.94 11.31 16 328510 30842 50245756
Insomnia 143.05 11.31 616 327910 174249 50102349
Post transplant lymphoproliferative disorder 141.53 11.31 155 328371 4049 50272549
Gastrointestinal haemorrhage 140.62 11.31 161 328365 73160 50203438
Hallucination 139.49 11.31 64 328462 46593 50230005
Coeliac disease 138.68 11.31 222 328304 8463 50268135
Abdominal pain upper 138.53 11.31 548 327978 158761 50117837
Metabolic acidosis 138.49 11.31 40 328486 38785 50237813
Sedation 137.54 11.31 18 328508 30592 50246006
Foot deformity 137 11.31 351 328175 18859 50257739
Serum sickness 137.00 11.31 121 328405 2411 50274187
Demyelination 135.42 11.31 181 328345 5845 50270753
Tumour lysis syndrome 132.90 11.31 200 328326 7221 50269377
Memory impairment 132.86 11.31 193 328333 79167 50197431
JC virus infection 132.11 11.31 103 328423 1712 50274886
Musculoskeletal deformity 131.59 11.31 81 328445 897 50275701
Swelling face 130.21 11.31 91 328435 52504 50224094
Blood glucose increased 128.95 11.31 164 328362 71160 50205438
Unresponsive to stimuli 128.34 11.31 22 328504 30587 50246011
Therapeutic response decreased 128.29 11.31 627 327899 46604 50229994
Lactic acidosis 127.30 11.31 30 328496 33325 50243273
Respiratory arrest 127.09 11.31 21 328505 29988 50246610
Coma 126.15 11.31 110 328416 56769 50219829
Ear pruritus 125.40 11.31 115 328411 2411 50274187
Emotional distress 123.77 11.31 19 328507 28644 50247954
Haematochezia 123.50 11.31 52 328474 39830 50236768
Hypotension 123.01 11.31 959 327567 234510 50042088
Disorientation 122.15 11.31 39 328487 35445 50241153
Plasma cell myeloma 121.87 11.31 27 328499 31295 50245303
Anaemia 121.05 11.31 1052 327474 251404 50025194
Basal cell carcinoma 119.91 11.31 379 328147 22977 50253621
Chest pain 119.86 11.31 666 327860 176216 50100382
Sleep disorder due to general medical condition, insomnia type 119.57 11.31 462 328064 30985 50245613
Dyskinesia 119.10 11.31 19 328507 27842 50248756
Back pain 118.76 11.31 888 327638 219142 50057456
Dysgeusia 118.50 11.31 52 328474 38864 50237734
Contrast media allergy 118.01 11.31 101 328425 1926 50274672
Joint stiffness 117.48 11.31 448 328078 29860 50246738
Blood pressure systolic increased 117.44 11.31 499 328027 34950 50241648
Balance disorder 116.86 11.31 173 328353 70417 50206181
Paraesthesia 116.77 11.31 395 328131 119848 50156750
Condition aggravated 116.45 11.31 2634 325892 294424 49982174
Hypokalaemia 115.64 11.31 249 328277 87743 50188855
Myelodysplastic syndrome 113.67 11.31 282 328244 14850 50261748
Headache 113.43 11.31 2467 326059 504068 49772530
Therapy cessation 112.87 11.31 17 328509 25994 50250604
Lethargy 111.57 11.31 94 328432 49338 50227260
Therapy non-responder 108.33 11.31 633 327893 50389 50226209
Ulcer 107.59 11.31 332 328194 19868 50256730
Depression 107.14 11.31 632 327894 164791 50111807
Herpes zoster 106.58 11.31 806 327720 69980 50206618
Muscle injury 106.09 11.31 500 328026 36611 50239987
Flatulence 105.71 11.31 30 328496 29428 50247170
Device issue 105.24 11.31 6 328520 19966 50256632
Immunodeficiency 104.77 11.31 270 328256 14558 50262040
Haematotoxicity 103.74 11.31 185 328341 7710 50268888
B-cell lymphoma recurrent 103.09 11.31 51 328475 352 50276246
Folliculitis 102.46 11.31 515 328011 38710 50237888
Elbow deformity 101.63 11.31 79 328447 1307 50275291
Type 2 diabetes mellitus 100.36 11.31 466 328060 33909 50242689
Tachycardia 99.41 11.31 324 328202 99439 50177159
Surgery 99.11 11.31 36 328490 30169 50246429
Sopor 98.83 11.31 8 328518 19871 50256727
Orthostatic hypotension 98.68 11.31 34 328492 29447 50247151
Disease recurrence 98.68 11.31 321 328205 19760 50256838
Grip strength decreased 98.66 11.31 233 328293 11888 50264710
SLE arthritis 97.26 11.31 57 328469 573 50276025
Injection site haemorrhage 97.24 11.31 12 328514 21334 50255264
Staphylococcal bacteraemia 96.84 11.31 138 328388 4739 50271859
Secondary immunodeficiency 96.56 11.31 72 328454 1116 50275482
White blood cell count abnormal 96.55 11.31 146 328380 5294 50271304
Arthritis 96.00 11.31 922 327604 85799 50190799
Therapy interrupted 95.14 11.31 10 328516 20142 50256456
Injection site bruising 94.52 11.31 61 328465 36707 50239891
Smooth muscle cell neoplasm 94.04 11.31 60 328466 711 50275887
Accidental overdose 94.02 11.31 9 328517 19524 50257074
Chronic lymphocytic leukaemia recurrent 93.68 11.31 38 328488 151 50276447
Accidental exposure to product 93.58 11.31 18 328508 23039 50253559
Irritable bowel syndrome 92.78 11.31 612 327914 50829 50225769
Asthma 91.20 11.31 287 328239 89050 50187548
Anaphylactic reaction 90.86 11.31 632 327894 53423 50223175
Palpitations 90.69 11.31 312 328214 94194 50182404
Renal failure 90.63 11.31 370 328156 106263 50170335
Sciatica 90.35 11.31 325 328201 21057 50255541
Product prescribing error 90.26 11.31 14 328512 20947 50255651
Confusional state 89.84 11.31 773 327753 185155 50091443
Irritability 89.74 11.31 36 328490 28390 50248208
Physical disability 89.58 11.31 83 328443 1764 50274834
Breast cancer stage III 89.31 11.31 108 328418 3148 50273450
Skin exfoliation 88.84 11.31 54 328472 33558 50243040
Epistaxis 88.22 11.31 176 328350 63778 50212820
Epstein-Barr virus infection 88.17 11.31 161 328365 6836 50269762
Injection site rash 87.96 11.31 4 328522 16173 50260425
Hypophagia 87.72 11.31 35 328491 27693 50248905
Nightmare 87.40 11.31 4 328522 16082 50260516
Red blood cell sedimentation rate 87.23 11.31 112 328414 3474 50273124
Dry skin 87.04 11.31 91 328435 43100 50233498
Osteonecrosis of jaw 86.33 11.31 52 328474 32474 50244124
Loss of consciousness 85.64 11.31 367 328159 103986 50172612
Blood creatine phosphokinase increased 85.54 11.31 32 328494 26335 50250263
Migraine 85.47 11.31 230 328296 75050 50201548
Rectal haemorrhage 84.97 11.31 75 328451 38483 50238115
Hyperglycaemia 84.93 11.31 67 328459 36338 50240260
Blood calcium decreased 84.39 11.31 16 328510 20690 50255908
Disturbance in attention 83.98 11.31 49 328477 31137 50245461
Blood alkaline phosphatase increased 83.90 11.31 72 328454 37454 50239144
Blood potassium decreased 83.68 11.31 70 328456 36875 50239723
Haematemesis 82.92 11.31 38 328488 27687 50248911
Abnormal behaviour 82.70 11.31 14 328512 19644 50256954
Restlessness 82.60 11.31 30 328496 25143 50251455
Vertigo 81.97 11.31 131 328395 51701 50224897
Skin ulcer 81.44 11.31 448 328078 34870 50241728
Diffuse large B-cell lymphoma 81.34 11.31 138 328388 5524 50271074
Disability 80.54 11.31 223 328303 12552 50264046
Blood pressure diastolic decreased 80.43 11.31 266 328260 16515 50260083
Blood immunoglobulin M decreased 80.17 11.31 53 328473 670 50275928
Obliterative bronchiolitis 79.85 11.31 78 328448 1775 50274823
Therapy partial responder 79.71 11.31 149 328377 6442 50270156
Red blood cell sedimentation rate abnormal 79.18 11.31 260 328266 16083 50260515
Bronchitis chronic 78.89 11.31 111 328415 3766 50272832
Chronic kidney disease 78.80 11.31 85 328441 39686 50236912
Neuropathy peripheral 78.35 11.31 342 328184 96415 50180183
Product substitution issue 78.02 11.31 3 328523 14054 50262544
Pulmonary oedema 77.10 11.31 124 328402 48814 50227784
Generalised tonic-clonic seizure 75.72 11.31 38 328488 26272 50250326
Surgical failure 75.26 11.31 56 328470 865 50275733
Onychomycosis 75.24 11.31 125 328401 4917 50271681
Speech disorder 74.95 11.31 72 328454 35476 50241122
Palmar-plantar erythrodysaesthesia syndrome 74.89 11.31 19 328507 20079 50256519
Cellulitis 74.70 11.31 224 328302 70574 50206024
Blood bilirubin increased 74.69 11.31 59 328467 31979 50244619
Blood urea increased 74.24 11.31 30 328496 23555 50253043
Spinal column injury 74.21 11.31 74 328452 1728 50274870
Coronary artery disease 74.14 11.31 51 328475 29675 50246923
Deformity 73.93 11.31 161 328365 7779 50268819
Injection site mass 73.46 11.31 8 328518 15672 50260926
Caesarean section 73.21 11.31 8 328518 15631 50260967
Metastases to bone 73.14 11.31 14 328512 17981 50258617
Metastases to liver 73.02 11.31 20 328506 20084 50256514
Withdrawal syndrome 72.96 11.31 13 328513 17577 50259021
Psoriatic arthropathy 72.74 11.31 539 327987 46493 50230105
Device malfunction 72.69 11.31 7 328519 15114 50261484
Mental status changes 72.44 11.31 77 328449 36195 50240403
Pulmonary hypertension 72.44 11.31 66 328460 33351 50243247
Liver function test increased 71.73 11.31 343 328183 25263 50251335
Full blood count decreased 71.03 11.31 28 328498 22318 50254280
Mobility decreased 70.57 11.31 812 327714 79136 50197462
Abortion spontaneous 70.47 11.31 101 328425 41671 50234927
Sleep disorder 70.43 11.31 623 327903 56660 50219938
Hypercalcaemia 69.96 11.31 319 328207 23033 50253565
Cytopenia 69.60 11.31 167 328359 8608 50267990
Aggression 69.56 11.31 25 328501 21091 50255507
Drug effective for unapproved indication 69.25 11.31 75 328451 1934 50274664
Diabetic ketoacidosis 68.34 11.31 16 328510 17856 50258742
Red cell distribution width decreased 68.32 11.31 57 328469 1048 50275550
Chronic obstructive pulmonary disease 67.89 11.31 154 328372 53281 50223317
Injection site warmth 67.78 11.31 6 328520 13860 50262738
Dysarthria 67.59 11.31 86 328440 37317 50239281
Syncope 67.45 11.31 392 328134 102610 50173988
Vascular access complication 66.94 11.31 57 328469 1079 50275519
Mean platelet volume decreased 66.83 11.31 67 328459 1575 50275023
Angioedema 66.67 11.31 88 328438 37588 50239010
Humoral immune defect 66.55 11.31 24 328502 63 50276535
Product storage error 66.54 11.31 3 328523 12221 50264377
Blood glucose decreased 66.36 11.31 18 328508 18193 50258405
Peripheral swelling 66.16 11.31 1778 326748 204158 50072440
Depressed mood 65.99 11.31 74 328452 33949 50242649
Mental disorder 65.98 11.31 30 328496 21961 50254637
Nervousness 65.62 11.31 50 328476 27601 50248997
Full blood count abnormal 65.49 11.31 35 328491 23353 50253245
Product administration error 65.44 11.31 23 328503 19676 50256922
Device dislocation 65.26 11.31 29 328497 21517 50255081
Infusion site reaction 65.17 11.31 76 328450 2130 50274468
Unevaluable event 65.06 11.31 125 328401 45941 50230657
Blister 64.74 11.31 843 327683 84575 50192023
Seronegative arthritis 64.25 11.31 73 328453 1988 50274610
Swollen tongue 63.92 11.31 55 328471 28575 50248023
Abdominal distension 63.80 11.31 250 328276 72653 50203945
Underdose 63.49 11.31 26 328500 20252 50256346
Oxygen saturation decreased 63.33 11.31 741 327785 72507 50204091
Hypervolaemia 63.26 11.31 44 328482 25455 50251143
Blood immunoglobulin G decreased 63.05 11.31 71 328455 1914 50274684
Foetal exposure during pregnancy 63.00 11.31 51 328475 27308 50249290
Frequent bowel movements 62.97 11.31 8 328518 13910 50262688
Head injury 62.91 11.31 39 328487 23981 50252617
Cerebral toxoplasmosis 62.78 11.31 45 328481 654 50275944
Urinary incontinence 61.99 11.31 55 328471 28153 50248445
Lower respiratory tract infection 61.80 11.31 914 327612 94287 50182311
COVID-19 pneumonia 61.53 11.31 155 328371 8240 50268358
Therapeutic response unexpected 61.35 11.31 14 328512 15901 50260697
Creatinine renal clearance decreased 61.30 11.31 4 328522 11877 50264721
Malignant neoplasm progression 61.30 11.31 231 328295 67893 50208705
Impaired healing 61.23 11.31 708 327818 69078 50207520
Hallucination, visual 61.16 11.31 16 328510 16566 50260032
Pre-existing disease 60.43 11.31 27 328499 143 50276455
Drug eruption 60.28 11.31 308 328218 23298 50253300
Pulmonary toxicity 60.24 11.31 120 328406 5442 50271156
Blood sodium decreased 60.17 11.31 31 328495 21116 50255482
Urinary retention 60.09 11.31 49 328477 26141 50250457
Pancreatitis 59.87 11.31 116 328410 42498 50234100
Tenosynovitis 59.41 11.31 177 328349 10388 50266210
Temperature regulation disorder 59.37 11.31 102 328424 4125 50272473
Hepatic function abnormal 59.20 11.31 75 328451 32606 50243992
Hyperlipidaemia 58.83 11.31 20 328506 17470 50259128
Joint destruction 58.32 11.31 97 328429 3819 50272779
Adjustment disorder with depressed mood 57.91 11.31 81 328445 2733 50273865
Haemoglobin decreased 57.86 11.31 537 327989 126679 50149919
Varicella zoster virus infection 57.83 11.31 76 328450 2413 50274185
Injection site urticaria 57.83 11.31 6 328520 12211 50264387
Extrapyramidal disorder 57.79 11.31 5 328521 11765 50264833
Fine motor skill dysfunction 57.62 11.31 99 328427 4004 50272594
Aspergillus infection 57.56 11.31 133 328393 6688 50269910
Hallucination, auditory 57.22 11.31 3 328523 10725 50265873
Laryngeal disorder 57.02 11.31 47 328479 849 50275749
Psoriasis 57.00 11.31 242 328284 68758 50207840
Acute myocardial infarction 56.41 11.31 64 328462 29209 50247389
Cognitive disorder 56.19 11.31 127 328399 43996 50232602
Abdominal pain lower 56.05 11.31 36 328490 21720 50254878
Haemophagocytic lymphohistiocytosis 55.71 11.31 152 328374 8481 50268117
Labelled drug-drug interaction medication error 55.66 11.31 3 328523 10474 50266124
Drug level increased 55.19 11.31 28 328498 19240 50257358
Jaundice 55.17 11.31 54 328472 26375 50250223
Product label confusion 54.90 11.31 37 328489 484 50276114
Nasal congestion 54.46 11.31 161 328365 50959 50225639
Hypersomnia 54.20 11.31 16 328510 15298 50261300
Gastric disorder 54.16 11.31 353 328173 29195 50247403
Bone swelling 54.14 11.31 52 328474 1158 50275440
Eye pain 53.95 11.31 63 328463 28386 50248212
Right ventricular failure 53.76 11.31 18 328508 15875 50260723
Bone marrow failure 53.71 11.31 335 328191 27289 50249309
Dislocation of vertebra 53.58 11.31 82 328444 3005 50273593
Hepatitis E 53.46 11.31 52 328474 1177 50275421
Lymphoma transformation 53.43 11.31 24 328502 129 50276469
Electric shock 53.38 11.31 48 328478 980 50275618
Therapy responder 53.12 11.31 31 328495 309 50276289
Wrist deformity 52.90 11.31 62 328464 1747 50274851
Femur fracture 52.61 11.31 102 328424 37362 50239236
Pallor 52.48 11.31 44 328482 23155 50253443
Muscle spasticity 52.25 11.31 23 328503 17161 50259437
Influenza like illness 52.24 11.31 194 328332 57265 50219333
Chromaturia 52.09 11.31 15 328511 14575 50262023
Arthrodesis 51.84 11.31 72 328454 2413 50274185
Hypoaesthesia 51.68 11.31 552 327974 126705 50149893
Glomerulonephritis 51.65 11.31 57 328469 1502 50275096
Hypoxia 51.62 11.31 165 328361 50958 50225640
COVID-19 51.55 11.31 496 328030 46166 50230432
Blood pressure decreased 51.33 11.31 188 328338 55721 50220877
Transient ischaemic attack 51.31 11.31 81 328445 32129 50244469
Dystonia 51.27 11.31 8 328518 11918 50264680
Vasculitis 51.11 11.31 203 328323 13788 50262810
Visual acuity reduced 50.96 11.31 34 328492 20105 50256493
Agranulocytosis 50.92 11.31 274 328252 21147 50255451
Obstructive airways disorder 50.77 11.31 19 328507 15633 50260965
Pruritus 50.74 11.31 1427 327099 282141 49994457
Complication associated with device 50.63 11.31 16 328510 14639 50261959
Meningoencephalitis viral 50.21 11.31 29 328497 283 50276315
Hypocalcaemia 50.20 11.31 60 328466 26756 50249842
Panic attack 49.83 11.31 32 328494 19310 50257288
Myoclonus 49.63 11.31 16 328510 14454 50262144
Cholelithiasis 49.42 11.31 108 328418 37865 50238733
Drug-induced liver injury 49.32 11.31 66 328460 28029 50248569
Cardiomegaly 49.03 11.31 21 328505 15924 50260674
Mean cell volume decreased 48.72 11.31 72 328454 2557 50274041
Cytomegalovirus infection reactivation 48.67 11.31 72 328454 2559 50274039
Drug reaction with eosinophilia and systemic symptoms 48.66 11.31 68 328458 28356 50248242
Lymphoma 48.55 11.31 155 328371 9446 50267152
Chest discomfort 48.15 11.31 378 328148 92344 50184254
Hyperhidrosis 48.11 11.31 361 328165 89065 50187533
Burning sensation 47.78 11.31 144 328382 45302 50231296
Lip swelling 47.75 11.31 54 328472 24682 50251916
Haematoma 47.40 11.31 78 328448 30432 50246166
Fluid retention 47.37 11.31 169 328357 50480 50226118
Gamma-glutamyltransferase increased 46.71 11.31 75 328451 29548 50247050
Incorrect route of product administration 46.58 11.31 32 328494 18634 50257964
Transfusion 46.56 11.31 13 328513 12892 50263706
Poor quality sleep 46.48 11.31 25 328501 16621 50259977
Device difficult to use 46.42 11.31 5 328521 9881 50266717
Hypomagnesaemia 46.41 11.31 49 328477 23107 50253491
Pollakiuria 46.12 11.31 52 328474 23799 50252799
Myelosuppression 46.10 11.31 192 328334 13325 50263273
Dyspnoea exertional 45.26 11.31 175 328351 51058 50225540
Cholecystitis chronic 45.13 11.31 5 328521 9664 50266934
Polyomavirus-associated nephropathy 45.07 11.31 53 328473 1499 50275099
Second primary malignancy 44.88 11.31 122 328404 6792 50269806
Pneumonia aspiration 44.77 11.31 83 328443 30921 50245677
Pulmonary embolism 44.66 11.31 433 328093 101271 50175327
Acquired haemophilia 44.61 11.31 41 328485 862 50275736
Cardiac disorder 44.60 11.31 137 328389 42842 50233756
Sinus bradycardia 44.47 11.31 15 328511 13168 50263430
Pulmonary arterial hypertension 44.19 11.31 40 328486 20279 50256319
Blood potassium increased 43.82 11.31 26 328500 16372 50260226
Peptic ulcer haemorrhage 43.75 11.31 43 328483 986 50275612
Illness 43.74 11.31 57 328469 24483 50252115
B-cell lymphoma refractory 43.53 11.31 18 328508 76 50276522
Respiratory depression 43.52 11.31 12 328514 11998 50264600
Melaena 43.32 11.31 67 328459 26797 50249801
Muscular weakness 43.21 11.31 401 328125 94612 50181986
Road traffic accident 42.96 11.31 57 328469 24295 50252303
Pneumocystis jirovecii infection 42.90 11.31 47 328479 1228 50275370
Hypokinesia 42.81 11.31 13 328513 12204 50264394
Incorrect product administration duration 42.78 11.31 5 328521 9270 50267328
West Nile viral infection 42.55 11.31 28 328498 351 50276247
Wheezing 42.30 11.31 233 328293 61814 50214784
Musculoskeletal disorder 41.97 11.31 223 328303 17126 50259472
Coagulopathy 41.88 11.31 33 328493 17911 50258687
Ankle arthroplasty 41.71 11.31 44 328482 1100 50275498
Delusion 41.34 11.31 9 328517 10560 50266038
Ageusia 41.18 11.31 12 328514 11571 50265027
Sensitivity to weather change 41.09 11.31 108 328418 5893 50270705
Sinus tachycardia 40.80 11.31 47 328479 21307 50255291
Vaginal haemorrhage 40.78 11.31 60 328466 24491 50252107
Torsade de pointes 40.74 11.31 13 328513 11822 50264776
Rhinorrhoea 40.73 11.31 184 328342 51399 50225199
Fear 40.40 11.31 22 328504 14527 50262071
Skin discolouration 40.33 11.31 96 328430 32661 50243937
Joint range of motion decreased 40.14 11.31 231 328295 18281 50258317
Sleep apnoea syndrome 39.97 11.31 58 328468 23810 50252788
Eye swelling 39.96 11.31 43 328483 20101 50256497
Faeces discoloured 39.76 11.31 28 328498 16096 50260502
Hip fracture 39.63 11.31 67 328459 25864 50250734
Ocular hyperaemia 39.50 11.31 44 328482 20248 50256350
Pelvic pain 39.17 11.31 12 328514 11201 50265397
Deep vein thrombosis 38.92 11.31 297 328229 73007 50203591
Adenovirus infection 38.79 11.31 72 328454 3096 50273502
Soft tissue disorder 38.73 11.31 85 328441 4129 50272469
X-ray abnormal 38.57 11.31 65 328461 2587 50274011
Psychotic disorder 38.53 11.31 51 328475 21761 50254837
Bunion operation 38.41 11.31 42 328484 1095 50275503
Leukopenia 38.36 11.31 634 327892 66894 50209704
Posterior reversible encephalopathy syndrome 38.27 11.31 195 328331 14733 50261865
Monocyte count increased 38.24 11.31 100 328426 5439 50271159
Circulatory collapse 38.24 11.31 44 328482 19956 50256642
Rash papular 38.12 11.31 17 328509 12587 50264011
Anger 38.05 11.31 13 328513 11320 50265278
Nerve injury 37.93 11.31 130 328396 8220 50268378
Altered state of consciousness 37.93 11.31 52 328474 21858 50254740
Parkinsonism 37.89 11.31 6 328520 8841 50267757
Cystitis haemorrhagic 37.87 11.31 78 328448 3624 50272974
Pancreatitis acute 37.82 11.31 60 328466 23752 50252846
Diverticulum 37.73 11.31 11 328515 10603 50265995
Mania 37.56 11.31 12 328514 10904 50265694
Blood iron abnormal 37.52 11.31 73 328453 3253 50273345
Oesophagitis 37.51 11.31 20 328506 13363 50263235
Ankle operation 37.47 11.31 43 328483 1184 50275414
Haemodialysis 37.37 11.31 5 328521 8357 50268241
Ventricular extrasystoles 37.19 11.31 11 328515 10505 50266093
Cardiac failure 37.18 11.31 315 328211 75725 50200873
Bronchitis 37.15 11.31 465 328061 103694 50172904
Exposure during pregnancy 37.14 11.31 557 327969 120458 50156140
Amnesia 36.91 11.31 145 328381 42115 50234483
Macular degeneration 36.80 11.31 24 328502 14364 50262234
Dementia 36.61 11.31 30 328496 15967 50260631
Mean cell haemoglobin decreased 36.35 11.31 72 328454 3251 50273347
Toxic epidermal necrolysis 36.16 11.31 50 328476 20942 50255656
Metastases to central nervous system 36.08 11.31 14 328512 11268 50265330
Anuria 35.88 11.31 14 328512 11230 50265368
Anaphylactic shock 35.73 11.31 47 328479 20108 50256490
Acidosis 35.62 11.31 11 328515 10216 50266382
Cytomegalovirus viraemia 35.62 11.31 88 328438 4621 50271977
Dysuria 35.52 11.31 83 328443 28421 50248177
Back injury 35.48 11.31 114 328412 6971 50269627
Face oedema 35.47 11.31 38 328488 17801 50258797
Tubulointerstitial nephritis 35.47 11.31 28 328498 15183 50261415
Mantle cell lymphoma recurrent 35.40 11.31 17 328509 109 50276489
Dysstasia 35.39 11.31 38 328488 17781 50258817
Infusion site pain 35.27 11.31 18 328508 12328 50264270
Retching 34.92 11.31 20 328506 12842 50263756
Nodule 34.82 11.31 209 328317 16794 50259804
Hysterectomy 34.59 11.31 5 328521 7885 50268713
Stevens-Johnson syndrome 34.36 11.31 55 328471 21697 50254901
Heart rate decreased 34.14 11.31 375 328151 36122 50240476
Drug ineffective for unapproved indication 34.10 11.31 246 328280 21035 50255563
Lipase increased 33.97 11.31 7 328519 8534 50268064
Eating disorder 33.91 11.31 30 328496 15379 50261219
Haematocrit decreased 33.85 11.31 115 328411 34861 50241737
Central nervous system lymphoma 33.78 11.31 43 328483 1322 50275276
Post procedural complication 33.73 11.31 29 328497 15075 50261523
Hypothermia 33.62 11.31 18 328508 11998 50264600
Immunoglobulins decreased 33.58 11.31 37 328489 973 50275625
Cough 33.58 11.31 1254 327272 240010 50036588
Disease progression 33.44 11.31 837 327689 95029 50181569
Ventricular tachycardia 33.40 11.31 32 328494 15789 50260809
Needle issue 33.36 11.31 4 328522 7271 50269327
Visual impairment 33.31 11.31 283 328243 67992 50208606
Ascites 33.30 11.31 120 328406 35741 50240857
Premature baby 33.30 11.31 42 328484 18295 50258303
Episcleritis 33.18 11.31 33 328493 768 50275830
Ear pain 33.16 11.31 85 328441 28198 50248400
Lung disorder 33.04 11.31 440 328086 44359 50232239
Seasonal allergy 33.00 11.31 28 328498 14648 50261950
Gastritis 32.91 11.31 107 328419 32876 50243722
Stomatitis 32.78 11.31 876 327650 100468 50176130
Taste disorder 32.74 11.31 7 328519 8317 50268281
Autoimmune haemolytic anaemia 32.68 11.31 77 328449 3922 50272676
Mydriasis 32.67 11.31 14 328512 10613 50265985
Electrolyte imbalance 32.58 11.31 38 328488 17131 50259467
Infection reactivation 32.55 11.31 36 328490 951 50275647
Mesenteritis 32.48 11.31 17 328509 134 50276464
Pancytopenia 32.14 11.31 743 327783 83287 50193311
Device breakage 31.97 11.31 11 328515 9536 50267062
General physical health deterioration 31.76 11.31 1177 327349 141257 50135341
Genital haemorrhage 31.72 11.31 3 328523 6571 50270027
Prothrombin time prolonged 31.71 11.31 9 328517 8829 50267769
Gastrointestinal disorder 31.57 11.31 820 327706 93636 50182962
Sleep disorder due to a general medical condition 31.56 11.31 5 328521 7366 50269232
Adverse event 31.52 11.31 428 328098 43335 50233263
Pericardial effusion 31.49 11.31 75 328451 25514 50251084
Drug level decreased 31.47 11.31 3 328523 6530 50270068
Babesiosis 30.90 11.31 19 328507 210 50276388
Feeling hot 30.85 11.31 140 328386 39062 50237536
Fatigue 30.82 11.31 5132 323394 702469 49574129
Mitral valve incompetence 30.71 11.31 41 328485 17430 50259168
Musculoskeletal pain 30.70 11.31 648 327878 71529 50205069
Nasopharyngitis 30.65 11.31 1539 326987 191388 50085210
Cyanosis 30.58 11.31 32 328494 15152 50261446
Steroid diabetes 30.50 11.31 34 328492 906 50275692
Infusion site swelling 30.43 11.31 5 328521 7171 50269427
Cervix disorder 30.27 11.31 25 328501 453 50276145
Red blood cell count decreased 30.25 11.31 115 328411 33720 50242878
Febrile bone marrow aplasia 30.21 11.31 100 328426 6211 50270387
Osteoarthritis 30.18 11.31 619 327907 67987 50208611
Blood triglycerides increased 30.13 11.31 18 328508 11294 50265304
Miosis 30.12 11.31 3 328523 6307 50270291
Tongue disorder 29.95 11.31 129 328397 9087 50267511
Dialysis 29.71 11.31 12 328514 9426 50267172
Neck deformity 29.46 11.31 49 328477 1929 50274669
Blood calcium increased 29.34 11.31 7 328519 7712 50268886
Pleural effusion 29.28 11.31 363 328163 81091 50195507
Mood altered 29.17 11.31 24 328502 12749 50263849
Dizziness postural 29.13 11.31 3 328523 6142 50270456
Affect lability 29.05 11.31 11 328515 8987 50267611
Neck mass 28.88 11.31 66 328460 3295 50273303
Lymphopenia 28.85 11.31 187 328339 15434 50261164
Metastases to lung 28.71 11.31 18 328508 11002 50265596
Renal injury 28.70 11.31 10 328516 8601 50267997
Nail disorder 28.62 11.31 132 328394 9576 50267022
Urine output decreased 28.59 11.31 16 328510 10405 50266193
Muscle rigidity 28.58 11.31 14 328512 9815 50266783
Delirium 28.52 11.31 139 328387 38053 50238545
Complication of device insertion 28.51 11.31 3 328523 6038 50270560
Haemorrhoids 28.41 11.31 50 328476 19003 50257595
Breast cancer metastatic 28.31 11.31 16 328510 10348 50266250
Flank pain 28.31 11.31 26 328500 13089 50263509
Cytokine release syndrome 28.17 11.31 121 328405 8513 50268085
Thyroid neoplasm 28.09 11.31 67 328459 3440 50273158
Food allergy 28.08 11.31 116 328410 8021 50268577
Pain in extremity 27.94 11.31 1467 327059 271398 50005200
Wrist surgery 27.87 11.31 30 328496 768 50275830
Neutropenic sepsis 27.77 11.31 172 328354 13975 50262623
Onychomadesis 27.72 11.31 67 328459 3469 50273129
Cytomegalovirus colitis 27.72 11.31 47 328479 1880 50274718
Infusion site erythema 27.63 11.31 11 328515 8716 50267882
Haemoptysis 27.62 11.31 80 328446 25493 50251105
Interstitial lung disease 27.57 11.31 492 328034 52684 50223914
Middle insomnia 27.55 11.31 15 328511 9906 50266692
Impaired gastric emptying 27.54 11.31 121 328405 8597 50268001
Skin irritation 27.48 11.31 8 328518 7719 50268879
Blood immunoglobulin A decreased 27.24 11.31 21 328505 343 50276255
Gastrosplenic fistula 27.06 11.31 11 328515 44 50276554
Hospice care 26.90 11.31 3 328523 5769 50270829
Product complaint 26.87 11.31 21 328505 11445 50265153
Systemic lupus erythematosus rash 26.85 11.31 44 328482 1711 50274887
Upper gastrointestinal haemorrhage 26.82 11.31 39 328487 15996 50260602
Major depression 26.65 11.31 6 328520 6878 50269720
Rash macular 26.62 11.31 53 328473 19224 50257374
Eosinophil count increased 26.56 11.31 12 328514 8818 50267780
Acute hepatitis B 26.55 11.31 20 328506 315 50276283
Intestinal sepsis 26.55 11.31 18 328508 238 50276360
Subdural haematoma 26.40 11.31 27 328499 12920 50263678
Atelectasis 26.30 11.31 49 328477 18221 50258377
Finger deformity 26.28 11.31 89 328437 5593 50271005
Inappropriate antidiuretic hormone secretion 26.13 11.31 28 328498 13115 50263483
Epstein-Barr virus infection reactivation 25.98 11.31 24 328502 508 50276090
Epilepsy 25.92 11.31 64 328462 21503 50255095
Hot flush 25.84 11.31 174 328352 43995 50232603
Procedural pain 25.83 11.31 31 328495 13801 50262797
Thinking abnormal 25.80 11.31 15 328511 9552 50267046
Heavy menstrual bleeding 25.78 11.31 38 328488 15499 50261099
Diplopia 25.70 11.31 54 328472 19206 50257392
Angina unstable 25.65 11.31 6 328520 6700 50269898
Tricuspid valve incompetence 25.62 11.31 27 328499 12743 50263855
Blood pressure diastolic increased 25.60 11.31 106 328420 7337 50269261
Tinnitus 25.55 11.31 95 328431 28037 50248561
Eye irritation 25.54 11.31 45 328481 17095 50259503
Intestinal obstruction 25.36 11.31 87 328439 26296 50250302
Treatment noncompliance 25.35 11.31 105 328421 30045 50246553
Cartilage atrophy 25.25 11.31 15 328511 155 50276443
Electrocardiogram abnormal 25.05 11.31 9 328517 7596 50269002
Small intestinal obstruction 25.03 11.31 41 328485 16027 50260571
Intervertebral discitis 24.89 11.31 54 328472 2602 50273996
Atrioventricular block first degree 24.83 11.31 5 328521 6196 50270402
Chronic lymphocytic leukaemia transformation 24.80 11.31 10 328516 39 50276559
Amenorrhoea 24.79 11.31 12 328514 8472 50268126
Apathy 24.75 11.31 9 328517 7539 50269059
Oedema 24.39 11.31 315 328211 69866 50206732
Concomitant disease aggravated 24.33 11.31 11 328515 8080 50268518
Fear of injection 24.29 11.31 91 328435 6012 50270586
Oral pruritus 24.24 11.31 41 328485 1637 50274961
Eructation 24.20 11.31 8 328518 7113 50269485
Blood lactate dehydrogenase abnormal 24.15 11.31 16 328510 203 50276395
Cerebral haemorrhage 24.15 11.31 92 328434 26960 50249638
Duodenal ulcer 24.12 11.31 7 328519 6768 50269830
Cardiogenic shock 24.12 11.31 40 328486 15559 50261039
Rheumatic disorder 24.03 11.31 39 328487 1504 50275094
Impaired quality of life 24.01 11.31 5 328521 6051 50270547
Nocturia 23.87 11.31 7 328519 6723 50269875
Encephalopathy 23.85 11.31 125 328401 33586 50243012
Sensory disturbance 23.74 11.31 25 328501 11804 50264794
Citrobacter bacteraemia 23.67 11.31 8 328518 16 50276582
Arteriosclerosis coronary artery 23.57 11.31 10 328516 7626 50268972
ADAMTS13 activity decreased 23.54 11.31 12 328514 89 50276509
Concussion 23.53 11.31 10 328516 7618 50268980
Choking 23.38 11.31 13 328513 8485 50268113
Abdominal tenderness 23.34 11.31 9 328517 7271 50269327
Salivary hypersecretion 23.12 11.31 7 328519 6584 50270014
Eczema 23.10 11.31 73 328453 22629 50253969
Wheelchair user 23.10 11.31 78 328448 4894 50271704
Breast pain 23.09 11.31 10 328516 7534 50269064
BK virus infection 23.03 11.31 55 328471 2826 50273772
Renal disorder 23.00 11.31 96 328430 27409 50249189
Glomerular filtration rate decreased 22.97 11.31 25 328501 11627 50264971
Leukoerythroblastosis 22.95 11.31 16 328510 222 50276376
Glycosylated haemoglobin increased 22.92 11.31 21 328505 10585 50266013
Maternal drugs affecting foetus 22.77 11.31 3 328523 5074 50271524
Pulseless electrical activity 22.70 11.31 8 328518 6833 50269765
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.67 11.31 48 328478 2274 50274324
Bacteraemia 22.64 11.31 166 328360 14267 50262331
Eyelid oedema 22.61 11.31 17 328509 9449 50267149
Bradyphrenia 22.57 11.31 6 328520 6146 50270452
Head discomfort 22.44 11.31 23 328503 10996 50265602
Joint dislocation 22.39 11.31 147 328379 12186 50264412
Platelet count abnormal 22.36 11.31 54 328472 2795 50273803
Muscle strain 22.33 11.31 9 328517 7079 50269519
Micturition urgency 22.22 11.31 13 328513 8251 50268347
Overlap syndrome 22.18 11.31 24 328502 618 50275980
Meningitis enteroviral 22.16 11.31 7 328519 10 50276588
Enthesopathy 22.09 11.31 99 328427 7094 50269504
Arteriosclerosis 22.07 11.31 16 328510 9061 50267537
Shock 22.01 11.31 65 328461 20585 50256013
Neuromyelitis optica spectrum disorder 22.01 11.31 27 328499 799 50275799
Haemorrhage 22.00 11.31 231 328295 53210 50223388
Oliguria 21.99 11.31 13 328513 8203 50268395
SARS-CoV-2 antibody test negative 21.92 11.31 8 328518 22 50276576
Respiratory acidosis 21.88 11.31 6 328520 6022 50270576
Hyperbilirubinaemia 21.83 11.31 18 328508 9552 50267046
Iron deficiency anaemia 21.80 11.31 48 328478 16786 50259812
Fracture 21.80 11.31 48 328478 16785 50259813
Low density lipoprotein increased 21.70 11.31 5 328521 5641 50270957
Hypernatraemia 21.66 11.31 7 328519 6314 50270284
Renal impairment 21.60 11.31 353 328173 75308 50201290
Blood pressure increased 21.54 11.31 1064 327462 132068 50144530
Thrombosis 21.53 11.31 245 328281 55588 50221010
Colitis ischaemic 21.43 11.31 18 328508 9465 50267133
Mucosal inflammation 21.37 11.31 373 328153 39769 50236829
Larynx irritation 21.23 11.31 12 328514 112 50276486
Groin pain 21.19 11.31 16 328510 8875 50267723
Dermatitis bullous 21.19 11.31 10 328516 7163 50269435
Device leakage 21.06 11.31 6 328520 5872 50270726
Feeling jittery 20.85 11.31 25 328501 11135 50265463
Tooth loss 20.85 11.31 7 328519 6163 50270435
Compression fracture 20.84 11.31 6 328520 5831 50270767
Feeding disorder 20.67 11.31 23 328503 10590 50266008
Aphasia 20.53 11.31 105 328421 28389 50248209
Coxsackie viral infection 20.50 11.31 8 328518 28 50276570
Amylase increased 20.49 11.31 5 328521 5425 50271173
Erythropoiesis abnormal 20.47 11.31 16 328510 267 50276331
Facial pain 20.42 11.31 12 328514 7597 50269001
Muscle tightness 20.33 11.31 22 328504 10258 50266340
Precancerous cells present 20.27 11.31 32 328494 1205 50275393
Ischaemic stroke 20.22 11.31 46 328480 15902 50260696
Hypovolaemia 20.15 11.31 19 328507 9446 50267152
Ankylosing spondylitis 20.08 11.31 96 328430 7069 50269529
Dry eye 20.02 11.31 124 328402 31971 50244627
Genitourinary tract infection 19.91 11.31 14 328512 197 50276401
Renal tubular necrosis 19.84 11.31 22 328504 10146 50266452
Anovulatory cycle 19.80 11.31 12 328514 129 50276469
Ocular lymphoma 19.80 11.31 9 328517 50 50276548
Sinus disorder 19.75 11.31 58 328468 18400 50258198
Multiple system atrophy 19.73 11.31 14 328512 200 50276398
Gestational diabetes 19.71 11.31 12 328514 7453 50269145
Gene mutation 19.62 11.31 32 328494 1239 50275359
Bundle branch block left 19.48 11.31 8 328518 6222 50270376
Amyotrophic lateral sclerosis 19.45 11.31 29 328497 1038 50275560
Gastrointestinal motility disorder 19.44 11.31 3 328523 4506 50272092
Psychomotor hyperactivity 19.42 11.31 19 328507 9282 50267316
Faecaloma 19.37 11.31 11 328515 7097 50269501
Exercise tolerance decreased 19.37 11.31 4 328522 4870 50271728
Knee operation 19.37 11.31 4 328522 4869 50271729
Pain of skin 19.33 11.31 14 328512 7933 50268665
Osteonecrosis 19.19 11.31 78 328448 22439 50254159
Device failure 19.16 11.31 6 328520 5522 50271076
Photosensitivity reaction 19.14 11.31 34 328492 12877 50263721
Musculoskeletal chest pain 19.12 11.31 59 328467 18427 50258171
Affective disorder 19.11 11.31 5 328521 5176 50271422
Accident 19.10 11.31 75 328451 5066 50271532
Acute myeloid leukaemia 19.06 11.31 165 328361 14909 50261689
Incontinence 19.05 11.31 22 328504 9963 50266635
Hyperthyroidism 19.03 11.31 31 328495 12144 50264454
Myelitis 18.96 11.31 31 328495 1203 50275395
Tumour flare 18.86 11.31 15 328511 257 50276341
Post procedural haemorrhage 18.77 11.31 12 328514 7258 50269340
Initial insomnia 18.74 11.31 5 328521 5110 50271488
Bladder disorder 18.73 11.31 13 328513 7530 50269068
Blood pressure inadequately controlled 18.69 11.31 3 328523 4377 50272221
Blood creatinine increased 18.67 11.31 365 328161 75795 50200803
Hepatic steatosis 18.64 11.31 88 328438 24296 50252302
Blood albumin decreased 18.61 11.31 36 328490 13200 50263398
Respiratory failure 18.60 11.31 450 328076 90731 50185867
Campylobacter gastroenteritis 18.55 11.31 17 328509 356 50276242
Non-cardiac chest pain 18.52 11.31 7 328519 5725 50270873
Muscle disorder 18.52 11.31 3 328523 4347 50272251
Injection site hypersensitivity 18.50 11.31 38 328488 1762 50274836
Abnormal loss of weight 18.46 11.31 5 328521 5059 50271539
Rhinitis allergic 18.43 11.31 12 328514 7188 50269410
Viral upper respiratory tract infection 18.36 11.31 92 328434 6904 50269694
Nephrogenic systemic fibrosis 18.35 11.31 3 328523 4319 50272279
Sputum discoloured 18.35 11.31 37 328489 13358 50263240
Subclavian artery occlusion 18.27 11.31 7 328519 23 50276575
Alanine aminotransferase abnormal 18.26 11.31 64 328462 4092 50272506
Wrong product administered 18.25 11.31 6 328520 5354 50271244
Enterovirus infection 18.20 11.31 23 328503 702 50275896
Cestode infection 18.15 11.31 15 328511 272 50276326
Premature labour 18.14 11.31 29 328497 11447 50265151
Dry mouth 18.12 11.31 256 328270 55922 50220676
Gout 18.12 11.31 29 328497 11441 50265157
Strongyloidiasis 18.09 11.31 25 328501 834 50275764
Spinal stenosis 18.07 11.31 38 328488 13512 50263086
Acute respiratory failure 18.05 11.31 111 328415 28671 50247927
Weight decreased 17.91 11.31 1216 327310 220029 50056569
Night sweats 17.83 11.31 136 328390 33438 50243160
Natural killer-cell leukaemia 17.81 11.31 10 328516 92 50276506
Epstein-Barr virus associated lymphoproliferative disorder 17.76 11.31 36 328490 1653 50274945
Myocardial ischaemia 17.75 11.31 30 328496 11583 50265015
Retinal deposits 17.74 11.31 9 328517 66 50276532
Hepatic necrosis 17.65 11.31 6 328520 5242 50271356
Atypical femur fracture 17.65 11.31 5 328521 4911 50271687
Limb operation 17.64 11.31 55 328471 3309 50273289
Lymphoedema 17.51 11.31 20 328506 9102 50267496
Application site erythema 17.47 11.31 4 328522 4534 50272064
Hypercholesterolaemia 17.45 11.31 133 328393 11570 50265028
Venoocclusive liver disease 17.35 11.31 64 328462 4197 50272401
Ventricular fibrillation 17.35 11.31 26 328500 10533 50266065
Enterovirus myocarditis 17.31 11.31 5 328521 4 50276594
Anal incontinence 17.27 11.31 30 328496 11460 50265138
Refractory anaemia with an excess of blasts 17.22 11.31 17 328509 392 50276206
T-lymphocyte count increased 17.19 11.31 10 328516 99 50276499
Proteinuria 17.15 11.31 174 328352 16423 50260175
Lacrimation increased 17.04 11.31 55 328471 16937 50259661
Oligohydramnios 17.01 11.31 8 328518 5742 50270856
Presyncope 16.97 11.31 90 328436 24108 50252490
B-lymphocyte count abnormal 16.96 11.31 8 328518 49 50276549
Antineutrophil cytoplasmic antibody increased 16.96 11.31 8 328518 49 50276549
Live birth 16.94 11.31 172 328354 16236 50260362
Jaundice cholestatic 16.92 11.31 6 328520 5105 50271493
Postoperative wound infection 16.91 11.31 18 328508 8457 50268141
Dysphonia 16.88 11.31 166 328360 38726 50237872
Conjunctival scar 16.84 11.31 6 328520 15 50276583
Dermatitis acneiform 16.82 11.31 3 328523 4054 50272544
Emotional disorder 16.81 11.31 32 328494 11804 50264794
CD4 lymphocytes increased 16.78 11.31 11 328515 137 50276461
Intermenstrual bleeding 16.58 11.31 12 328514 6802 50269796
Infected seroma 16.58 11.31 9 328517 77 50276521
Medication error 16.57 11.31 152 328374 35952 50240646
Pneumonia cytomegaloviral 16.55 11.31 38 328488 1903 50274695
Drug dependence 16.50 11.31 69 328457 19690 50256908
Personality change 16.47 11.31 8 328518 5637 50270961
Walking aid user 16.47 11.31 84 328442 6349 50270249
Drug tolerance 16.44 11.31 70 328456 4906 50271692
Lung diffusion test decreased 16.38 11.31 20 328506 589 50276009
Toxic skin eruption 16.35 11.31 30 328496 11221 50265377
Abortion induced 16.35 11.31 22 328504 9322 50267276
Selective IgG subclass deficiency 16.32 11.31 5 328521 6 50276592
Heparin-induced thrombocytopenia 16.29 11.31 3 328523 3962 50272636
Personality disorder 16.28 11.31 4 328522 4320 50272278
Catheter site erythema 16.28 11.31 3 328523 3959 50272639
Restless legs syndrome 16.26 11.31 51 328475 15846 50260752
Dysphagia 16.24 11.31 381 328145 77137 50199461
Adenovirus reactivation 16.23 11.31 10 328516 111 50276487
Extrasystoles 16.23 11.31 5 328521 4650 50271948
Leukaemic lymphoma 16.20 11.31 9 328517 81 50276517
Vulvovaginal ulceration 16.18 11.31 4 328522 0 50276598
Acute flaccid myelitis 16.18 11.31 4 328522 0 50276598
Bone density abnormal 16.17 11.31 50 328476 2995 50273603
Motor dysfunction 16.09 11.31 17 328509 8014 50268584
Device use error 16.09 11.31 7 328519 5259 50271339
Haemodynamic instability 16.06 11.31 17 328509 8007 50268591
Crying 16.01 11.31 73 328453 20343 50256255
Bronchopulmonary aspergillosis 15.98 11.31 94 328432 7498 50269100
Malnutrition 15.96 11.31 39 328487 13150 50263448
Human herpesvirus 6 infection 15.94 11.31 45 328481 2561 50274037
Enterococcal bacteraemia 15.92 11.31 29 328497 1229 50275369
Device adhesion issue 15.84 11.31 3 328523 3882 50272716
Thirst 15.83 11.31 28 328498 10622 50265976
Leukocytosis 15.82 11.31 84 328442 22495 50254103
Allergic oedema 15.78 11.31 22 328504 740 50275858
Osteopenia 15.76 11.31 57 328469 16961 50259637
Eosinophilia 15.65 11.31 65 328461 18587 50258011
Mucocutaneous ulceration 15.63 11.31 11 328515 155 50276443
Hypoxic-ischaemic encephalopathy 15.59 11.31 3 328523 3839 50272759
Dyspepsia 15.58 11.31 364 328162 73733 50202865
Clear cell renal cell carcinoma 15.56 11.31 28 328498 1175 50275423
Brain natriuretic peptide increased 15.53 11.31 5 328521 4522 50272076
Splenic marginal zone lymphoma recurrent 15.49 11.31 5 328521 8 50276590
Escherichia bacteraemia 15.48 11.31 50 328476 3066 50273532
Scoliosis 15.46 11.31 12 328514 6564 50270034
Tachypnoea 15.45 11.31 46 328480 14531 50262067
Clonus 15.45 11.31 4 328522 4171 50272427
Potentiating drug interaction 15.44 11.31 3 328523 3813 50272785
Hypotonia 15.44 11.31 18 328508 8116 50268482
Subarachnoid haemorrhage 15.42 11.31 29 328497 10747 50265851
Supraventricular tachycardia 15.37 11.31 38 328488 12763 50263835
Polyomavirus viraemia 15.37 11.31 17 328509 449 50276149
Malignant transformation 15.37 11.31 15 328511 341 50276257
Cerebral infarction 15.34 11.31 80 328446 21524 50255074
Hyperreflexia 15.33 11.31 7 328519 5111 50271487
Peripheral coldness 15.32 11.31 27 328499 10256 50266342
Heart rate irregular 15.31 11.31 69 328457 19291 50257307
Pulse absent 15.31 11.31 6 328520 4800 50271798
Cholecystitis 15.27 11.31 43 328483 13828 50262770
Tooth extraction 15.25 11.31 22 328504 9053 50267545
Hand fracture 15.22 11.31 5 328521 4463 50272135
Hepatic failure 15.21 11.31 135 328391 32148 50244450
Vitamin D deficiency 15.19 11.31 32 328494 11370 50265228
5q minus syndrome 15.16 11.31 12 328514 204 50276394
Frustration tolerance decreased 15.15 11.31 9 328517 5665 50270933
Erythema multiforme 15.14 11.31 22 328504 9028 50267570
Thrombocytopenia 15.14 11.31 992 327534 126681 50149917
Upper-airway cough syndrome 15.09 11.31 20 328506 8530 50268068
Gastric stenosis 15.08 11.31 8 328518 65 50276533
Pharyngeal paraesthesia 15.08 11.31 31 328495 1438 50275160
Movement disorder 15.08 11.31 61 328465 17571 50259027
Retinitis 15.06 11.31 36 328490 1851 50274747
Internal haemorrhage 14.94 11.31 5 328521 4412 50272186
Primary immunodeficiency syndrome 14.82 11.31 7 328519 43 50276555
Chronic lymphocytic leukaemia refractory 14.82 11.31 7 328519 43 50276555
Vaccination failure 14.81 11.31 15 328511 357 50276241
Ganglioneuroma 14.76 11.31 10 328516 132 50276466
Proctalgia 14.74 11.31 7 328519 4996 50271602
B-cell aplasia 14.69 11.31 7 328519 44 50276554
Activated partial thromboplastin time prolonged 14.66 11.31 12 328514 6390 50270208
Crystal nephropathy 14.64 11.31 22 328504 793 50275805
Brain oedema 14.64 11.31 37 328489 12333 50264265
Septic shock 14.61 11.31 480 328046 56695 50219903
Cryptococcosis 14.59 11.31 23 328503 865 50275733
Foetal death 14.58 11.31 19 328507 8161 50268437
Blood chloride decreased 14.52 11.31 7 328519 4954 50271644
Cardiac pacemaker insertion 14.51 11.31 3 328523 3650 50272948
Feeling drunk 14.51 11.31 3 328523 3650 50272948
Diffuse alveolar damage 14.50 11.31 22 328504 800 50275798
Myeloid leukaemia 14.50 11.31 14 328512 314 50276284
Dyspnoea at rest 14.48 11.31 3 328523 3644 50272954
Toxic neuropathy 14.48 11.31 15 328511 367 50276231
Eye pruritus 14.44 11.31 38 328488 12496 50264102
Flushing 14.43 11.31 328 328198 66687 50209911
Lower gastrointestinal haemorrhage 14.42 11.31 14 328512 6865 50269733
Blood pressure abnormal 14.42 11.31 39 328487 12708 50263890
Nail pigmentation 14.41 11.31 11 328515 177 50276421
Gastrointestinal sounds abnormal 14.41 11.31 3 328523 3631 50272967
Cholestasis 14.40 11.31 101 328425 25300 50251298
Emphysema 14.35 11.31 23 328503 9070 50267528
Hypertonia 14.34 11.31 4 328522 3969 50272629
Injection site haematoma 14.32 11.31 11 328515 6049 50270549
Secretion discharge 14.32 11.31 26 328500 9765 50266833
Bronchiectasis 14.31 11.31 115 328411 10168 50266430
Photopsia 14.30 11.31 4 328522 3962 50272636
Limb mass 14.27 11.31 44 328482 2631 50273967
Mental impairment 14.27 11.31 36 328490 12008 50264590
Cholecystectomy 14.25 11.31 24 328502 9279 50267319
Mantle cell lymphoma 14.25 11.31 16 328510 430 50276168
Cerebral atrophy 14.24 11.31 6 328520 4595 50272003
Combined immunodeficiency 14.22 11.31 9 328517 105 50276493
Cholesteatoma 14.21 11.31 10 328516 141 50276457
Hepatitis 14.18 11.31 133 328393 31320 50245278
Large intestine polyp 14.16 11.31 16 328510 7316 50269282
Aspiration 14.10 11.31 24 328502 9240 50267358
Psychiatric symptom 14.08 11.31 6 328520 4564 50272034
Hepatitis B surface antigen positive 14.07 11.31 7 328519 49 50276549
Partial seizures 14.04 11.31 7 328519 4858 50271740
Quadrantanopia 14.04 11.31 6 328520 28 50276570
Ammonia increased 14.00 11.31 5 328521 4236 50272362
Spinal operation 14.00 11.31 12 328514 6248 50270350
Pseudomonas infection 13.97 11.31 107 328419 9323 50267275
Metastases to lymph nodes 13.92 11.31 15 328511 7009 50269589
CD8 lymphocytes decreased 13.80 11.31 10 328516 148 50276450
Abnormal faeces 13.77 11.31 5 328521 4191 50272407
Sensory loss 13.76 11.31 18 328508 7720 50268878
Lupus nephritis 13.76 11.31 40 328486 2315 50274283
Peptic ulcer 13.75 11.31 4 328522 3862 50272736
Liver injury 13.75 11.31 232 328294 24574 50252024
Mucocutaneous leishmaniasis 13.70 11.31 14 328512 337 50276261
Herpes zoster infection neurological 13.63 11.31 10 328516 151 50276447
Pemphigoid 13.61 11.31 11 328515 5896 50270702
Rheumatoid lung 13.58 11.31 41 328485 2424 50274174
Allergy to chemicals 13.55 11.31 28 328498 1304 50275294
Acute biphenotypic leukaemia 13.50 11.31 7 328519 54 50276544
Electrocardiogram ST segment elevation 13.50 11.31 3 328523 3470 50273128
Oropharyngeal pain 13.49 11.31 393 328133 77408 50199190
Scar 13.48 11.31 36 328490 11782 50264816
Vitreous floaters 13.41 11.31 9 328517 5305 50271293
Mixed liver injury 13.37 11.31 3 328523 3448 50273150
Injection site discomfort 13.34 11.31 4 328522 3786 50272812
Hypoacusis 13.28 11.31 79 328447 20568 50256030
Steatohepatitis 13.27 11.31 16 328510 465 50276133
Joint effusion 13.21 11.31 136 328390 12885 50263713
Rib fracture 13.19 11.31 72 328454 19149 50257449
Germ cell cancer 13.19 11.31 7 328519 57 50276541
Premenstrual syndrome 13.17 11.31 18 328508 594 50276004
Systemic sclerosis pulmonary 13.15 11.31 5 328521 16 50276582
Immunodeficiency common variable 13.15 11.31 9 328517 121 50276477
Skin plaque 13.12 11.31 13 328513 6315 50270283
Body temperature increased 13.09 11.31 135 328391 31206 50245392
Drug level below therapeutic 13.07 11.31 4 328522 3736 50272862
Heart rate abnormal 13.07 11.31 56 328470 3936 50272662
Product preparation error 13.06 11.31 6 328520 4366 50272232
Gallbladder disorder 13.04 11.31 60 328466 16682 50259916
Chronic lymphocytic leukaemia 13.03 11.31 39 328487 2294 50274304
Lower limb fracture 13.01 11.31 48 328478 14198 50262400
Haemorrhagic stroke 13.00 11.31 9 328517 5219 50271379
Jaw disorder 12.98 11.31 8 328518 4935 50271663
Galactorrhoea 12.98 11.31 4 328522 3719 50272879
Capillaritis 12.97 11.31 8 328518 89 50276509
Hepatitis C RNA increased 12.96 11.31 9 328517 124 50276474
Ventricular septal defect 12.95 11.31 5 328521 4036 50272562
Ocular discomfort 12.94 11.31 3 328523 3370 50273228
Bundle branch block right 12.93 11.31 7 328519 4638 50271960
Incorrect dosage administered 12.93 11.31 32 328494 1682 50274916
Aplasia 12.88 11.31 54 328472 3759 50272839
Multiple sclerosis 12.87 11.31 79 328447 20414 50256184
Ulcer haemorrhage 12.87 11.31 3 328523 3358 50273240
Ligament sprain 12.83 11.31 31 328495 10494 50266104
Encephalitis 12.82 11.31 87 328439 7293 50269305
Biopsy bone marrow abnormal 12.80 11.31 12 328514 259 50276339
Urticaria 12.78 11.31 699 327827 128862 50147736
Cryoglobulinaemia 12.71 11.31 15 328511 426 50276172
Blood creatine increased 12.71 11.31 8 328518 4879 50271719
Graft versus host disease in skin 12.68 11.31 41 328485 2515 50274083
Apnoea 12.60 11.31 16 328510 6950 50269648
Lymphadenectomy 12.59 11.31 22 328504 902 50275696
Gastritis erosive 12.55 11.31 9 328517 5125 50271473
Blood urine present 12.55 11.31 42 328484 12791 50263807
Complement factor C3 decreased 12.54 11.31 11 328515 217 50276381
Mycobacterium chelonae infection 12.54 11.31 15 328511 432 50276166
Arrhythmia 12.53 11.31 146 328380 32986 50243612
Metabolic encephalopathy 12.49 11.31 9 328517 5112 50271486
Oral discomfort 12.46 11.31 92 328434 7925 50268673
Stem cell transplant 12.44 11.31 31 328495 1637 50274961
Atrioventricular block second degree 12.42 11.31 4 328522 3617 50272981
Photophobia 12.42 11.31 52 328474 14835 50261763
Nail bed inflammation 12.42 11.31 14 328512 378 50276220
Procedural complication 12.40 11.31 8 328518 4815 50271783
Urine odour abnormal 12.39 11.31 10 328516 5363 50271235
Lymphoproliferative disorder 12.38 11.31 44 328482 2833 50273765
Foot fracture 12.33 11.31 78 328448 20013 50256585
Ureaplasma infection 12.32 11.31 16 328510 502 50276096
Staphylococcal infection 12.32 11.31 160 328366 35456 50241142
Drug level above therapeutic 12.31 11.31 5 328521 3915 50272683
Electrocardiogram T wave inversion 12.31 11.31 3 328523 3258 50273340
Herpes simplex reactivation 12.27 11.31 14 328512 383 50276215
Hepatitis B core antibody positive 12.25 11.31 10 328516 178 50276420
Hypomania 12.24 11.31 7 328519 4498 50272100
Stupor 12.22 11.31 4 328522 3579 50273019
Ovarian hyperstimulation syndrome 12.21 11.31 3 328523 3241 50273357
Laryngeal pain 12.18 11.31 6 328520 4193 50272405
Transient hypogammaglobulinaemia of infancy 12.18 11.31 6 328520 41 50276557
Central nervous system viral infection 12.18 11.31 8 328518 100 50276498
Hypoglobulinaemia 12.17 11.31 4 328522 7 50276591
Encephalitis eastern equine 12.13 11.31 3 328523 0 50276598
Encephalitis enteroviral 12.13 11.31 3 328523 0 50276598
Pneumonia viral 12.13 11.31 81 328445 6753 50269845
JC polyomavirus test positive 12.10 11.31 24 328502 1085 50275513
Chest wall tumour 12.06 11.31 6 328520 42 50276556
Scleroderma renal crisis 12.04 11.31 12 328514 280 50276318
Refractory cytopenia with unilineage dysplasia 12.03 11.31 16 328510 514 50276084
Blood lactate dehydrogenase increased 11.98 11.31 186 328340 19376 50257222
Exostosis 11.96 11.31 122 328404 11531 50265067
Central nervous system enteroviral infection 11.93 11.31 5 328521 22 50276576
Pulmonary mass 11.90 11.31 179 328347 18526 50258072
Rheumatoid factor 11.89 11.31 7 328519 71 50276527
Lip pruritus 11.87 11.31 19 328507 724 50275874
Smear cervix abnormal 11.86 11.31 42 328484 2699 50273899
Facial bones fracture 11.84 11.31 3 328523 3174 50273424
Coronary artery occlusion 11.82 11.31 19 328507 7484 50269114
Pelvic fracture 11.75 11.31 37 328489 11483 50265115
Blood immunoglobulin M increased 11.75 11.31 11 328515 237 50276361
Cranial nerve disorder 11.71 11.31 13 328513 345 50276253
Gingival swelling 11.66 11.31 5 328521 3790 50272808
Serum ferritin increased 11.60 11.31 10 328516 5192 50271406
Ecchymosis 11.59 11.31 31 328495 10138 50266460
Lichen sclerosus 11.58 11.31 22 328504 963 50275635
Meningitis cryptococcal 11.56 11.31 24 328502 1121 50275477
Polydipsia 11.55 11.31 3 328523 3121 50273477
Uterine leiomyoma 11.50 11.31 21 328505 7870 50268728
Gastroenteritis viral 11.50 11.31 73 328453 18713 50257885
Troponin increased 11.48 11.31 22 328504 8096 50268502
Stillbirth 11.48 11.31 13 328513 5939 50270659
Sinusitis 11.45 11.31 1270 327256 169288 50107310
Paranoia 11.45 11.31 32 328494 10316 50266282
Granuloma 11.45 11.31 62 328464 4796 50271802
Chronic hepatitis 11.44 11.31 20 328506 820 50275778
Stent placement 11.44 11.31 4 328522 3434 50273164
Systemic candida 11.44 11.31 42 328484 2748 50273850
Lupus vulgaris 11.43 11.31 17 328509 607 50275991
Viral sepsis 11.42 11.31 5 328521 25 50276573
Hiatus hernia 11.37 11.31 71 328455 18273 50258325
Catatonia 11.36 11.31 5 328521 3731 50272867

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1475.10 11.81 3932 137922 296868 29135805
Febrile neutropenia 1398.49 11.81 2167 139687 110073 29322600
Progressive multifocal leukoencephalopathy 907.24 11.81 549 141305 8170 29424503
Intentional product use issue 867.68 11.81 1044 140810 41454 29391219
Neutropenia 844.06 11.81 1913 139941 129798 29302875
Hepatitis B 671.38 11.81 384 141470 5113 29427560
Product use in unapproved indication 669.76 11.81 1361 140493 85514 29347159
Diffuse large B-cell lymphoma recurrent 579.42 11.81 272 141582 2325 29430348
Infusion related reaction 570.89 11.81 866 140988 43020 29389653
Drug ineffective 564.94 11.81 3309 138545 359861 29072812
Hypogammaglobulinaemia 486.84 11.81 321 141533 5586 29427087
Hepatitis B reactivation 477.80 11.81 256 141598 2973 29429700
Pneumocystis jirovecii pneumonia 435.14 11.81 467 141387 16312 29416361
Myelodysplastic syndrome 385.61 11.81 451 141403 17343 29415330
Tumour lysis syndrome 373.40 11.81 394 141460 13490 29419183
Completed suicide 371.45 11.81 14 141840 90232 29342441
Cytomegalovirus infection 365.86 11.81 502 141352 22713 29409960
Drug interaction 365.58 11.81 250 141604 197135 29235538
Disease progression 345.45 11.81 1018 140836 80898 29351775
Apparent death 332.21 11.81 208 141646 3296 29429377
Synovitis 327.13 11.81 328 141526 10562 29422111
Contraindicated product administered 310.70 11.81 410 141444 17856 29414817
Toxicity to various agents 294.32 11.81 241 141613 173420 29259253
Chills 284.37 11.81 869 140985 70431 29362242
Lymphoma 280.58 11.81 288 141566 9540 29423133
Bone marrow failure 279.51 11.81 485 141369 26964 29405709
Overdose 264.55 11.81 35 141819 79784 29352889
Fall 256.79 11.81 283 141571 176895 29255778
Drug intolerance 240.91 11.81 639 141215 47740 29384933
Product dose omission issue 235.55 11.81 84 141770 96299 29336374
Rhabdomyolysis 232.42 11.81 15 141839 60793 29371880
Cytopenia 232.30 11.81 261 141593 9598 29423075
Therapy partial responder 220.86 11.81 190 141664 5009 29427664
Diffuse large B-cell lymphoma refractory 219.43 11.81 101 141753 821 29431852
Pyrexia 207.73 11.81 2198 139656 285424 29147249
Neutrophil count decreased 206.39 11.81 565 141289 43002 29389671
B-cell lymphoma recurrent 205.94 11.81 86 141768 537 29432136
Myelosuppression 205.67 11.81 273 141581 11954 29420719
Treatment failure 201.50 11.81 505 141349 36434 29396239
Lymphopenia 197.30 11.81 282 141572 13251 29419422
Post transplant lymphoproliferative disorder 192.32 11.81 180 141674 5313 29427360
Pancytopenia 191.13 11.81 848 141006 82320 29350353
Lymphadenopathy 184.91 11.81 386 141468 24663 29408010
Agranulocytosis 184.76 11.81 342 141512 19998 29412675
Infection 183.53 11.81 792 141062 75959 29356714
Haematotoxicity 178.11 11.81 189 141665 6510 29426163
Disease recurrence 172.25 11.81 289 141565 15625 29417048
Dizziness 166.01 11.81 420 141434 189264 29243409
Intentional overdose 165.58 11.81 4 141850 38524 29394149
Bronchopulmonary aspergillosis 165.13 11.81 247 141607 12097 29420576
Neutropenic sepsis 160.24 11.81 237 141617 11490 29421183
Mantle cell lymphoma recurrent 158.78 11.81 67 141787 431 29432242
Joint swelling 156.62 11.81 559 141295 49071 29383602
Anxiety 156.51 11.81 109 141745 85256 29347417
Sepsis 153.04 11.81 1189 140665 141493 29291180
Second primary malignancy 152.00 11.81 174 141680 6531 29426142
Chronic lymphocytic leukaemia recurrent 151.78 11.81 60 141794 318 29432355
Somnolence 148.50 11.81 139 141715 93816 29338857
Hypoglycaemia 144.84 11.81 28 141826 48318 29384355
Epstein-Barr virus infection 141.86 11.81 167 141687 6462 29426211
Acquired gene mutation 140.63 11.81 83 141771 1175 29431498
Diffuse large B-cell lymphoma 137.45 11.81 160 141694 6116 29426557
COVID-19 136.05 11.81 431 141423 35583 29397090
Diverticulitis 135.56 11.81 277 141577 17427 29415246
White blood cell count decreased 132.95 11.81 767 141087 82595 29350078
Hospitalisation 132.87 11.81 29 141825 45959 29386714
B-lymphocyte count decreased 129.51 11.81 59 141795 467 29432206
Blood pressure diastolic abnormal 126.57 11.81 102 141752 2449 29430224
Herpes zoster 125.96 11.81 373 141481 29679 29402994
COVID-19 pneumonia 125.17 11.81 189 141665 9333 29423340
Febrile bone marrow aplasia 124.95 11.81 165 141689 7186 29425487
Confusional state 123.06 11.81 269 141585 127608 29305065
Hallucination 121.70 11.81 32 141822 44680 29387993
Muscle spasms 120.73 11.81 82 141772 65000 29367673
International normalised ratio increased 120.31 11.81 32 141822 44340 29388333
Electrocardiogram QT prolonged 114.65 11.81 18 141836 36119 29396554
Aspergillus infection 114.29 11.81 192 141662 10389 29422284
Leukopenia 113.49 11.81 545 141309 54658 29378015
Diarrhoea 112.91 11.81 1037 140817 331661 29101012
Mucosal inflammation 111.98 11.81 370 141484 31225 29401448
Pneumocystis jirovecii infection 110.42 11.81 75 141779 1373 29431300
Fatigue 109.89 11.81 982 140872 315839 29116834
Red blood cell sedimentation rate increased 109.51 11.81 156 141698 7305 29425368
Thrombocytopenia 107.65 11.81 1053 140801 133770 29298903
Cytokine release syndrome 106.09 11.81 210 141644 12909 29419764
Suicide attempt 105.96 11.81 18 141836 34092 29398581
Suicidal ideation 104.20 11.81 20 141834 34696 29397977
Cytomegalovirus infection reactivation 104.09 11.81 103 141751 3261 29429412
Pneumonia cytomegaloviral 103.86 11.81 93 141761 2589 29430084
Aggression 103.50 11.81 22 141832 35519 29397154
Vomiting 102.53 11.81 598 141256 211662 29221011
Plasma cell myeloma 102.08 11.81 26 141828 37089 29395584
Chondropathy 101.32 11.81 60 141794 855 29431818
JC virus infection 100.86 11.81 79 141775 1818 29430855
Gait disturbance 98.69 11.81 124 141730 73225 29359448
Inappropriate schedule of product administration 96.84 11.81 46 141808 44426 29388247
Blood creatine phosphokinase increased 96.55 11.81 37 141817 40607 29392066
Agitation 96.00 11.81 64 141790 51240 29381433
Seizure 95.35 11.81 189 141665 92934 29339739
Cytomegalovirus chorioretinitis 94.42 11.81 96 141758 3142 29429531
No adverse event 94.26 11.81 238 141616 17240 29415433
Cerebrovascular accident 93.44 11.81 140 141714 76771 29355902
Pulmonary embolism 91.64 11.81 655 141199 75879 29356794
Depression 91.38 11.81 168 141686 84979 29347694
Blood pressure systolic abnormal 89.81 11.81 78 141776 2083 29430590
Ill-defined disorder 89.72 11.81 183 141671 11495 29421178
Septic shock 89.71 11.81 560 141294 62000 29370673
Atlantoaxial instability 89.07 11.81 40 141814 305 29432368
Coma 88.71 11.81 39 141815 39411 29393262
Pulmonary thrombosis 88.70 11.81 132 141722 6433 29426240
Acute myeloid leukaemia 88.15 11.81 224 141630 16289 29416384
Spinal instability 86.91 11.81 40 141814 325 29432348
Onychoclasis 86.77 11.81 70 141784 1683 29430990
Mineral metabolism disorder 86.18 11.81 40 141814 332 29432341
Cardio-respiratory arrest 85.78 11.81 70 141784 50531 29382142
Intentional product misuse 84.95 11.81 30 141824 34631 29398042
Dislocation of vertebra 83.51 11.81 40 141814 359 29432314
Arthropathy 83.25 11.81 260 141594 21294 29411379
Squamous cell carcinoma 82.77 11.81 164 141690 10087 29422586
Platelet count decreased 82.74 11.81 816 141038 103856 29328817
Loss of consciousness 81.35 11.81 144 141710 73912 29358761
Bradycardia 81.14 11.81 118 141736 65511 29367162
Serum sickness 80.08 11.81 67 141787 1698 29430975
Sarcoidosis 78.31 11.81 79 141775 2561 29430112
Injection site pain 77.96 11.81 29 141825 32417 29400256
Syncope 77.53 11.81 172 141682 81199 29351474
Autoimmune haemolytic anaemia 77.50 11.81 94 141760 3754 29428919
Wrong technique in product usage process 77.37 11.81 27 141827 31401 29401272
Lymphoma transformation 75.06 11.81 29 141825 143 29432530
Hyponatraemia 74.75 11.81 131 141723 67502 29365171
Knee arthroplasty 74.50 11.81 114 141740 5695 29426978
Myocardial infarction 73.68 11.81 276 141578 110020 29322653
Decreased appetite 73.58 11.81 403 141451 144939 29287734
Memory impairment 73.07 11.81 42 141812 36428 29396245
Herpes simplex 72.88 11.81 103 141751 4787 29427886
Oxygen saturation decreased 72.56 11.81 415 141439 44522 29388151
Blood pressure fluctuation 72.29 11.81 235 141619 19659 29413014
Metabolic acidosis 71.79 11.81 46 141808 37616 29395057
Coronary artery disease 71.39 11.81 64 141790 44126 29388547
C-reactive protein increased 70.96 11.81 408 141446 43855 29388818
Constipation 70.33 11.81 295 141559 113865 29318808
Drug effective for unapproved indication 69.70 11.81 57 141797 1398 29431275
Acne cystic 69.61 11.81 38 141816 459 29432214
Basal cell carcinoma 69.05 11.81 208 141646 16702 29415971
Myalgia 68.44 11.81 159 141695 73860 29358813
Accidental overdose 68.21 11.81 4 141850 17589 29415084
Pneumonia 67.76 11.81 2011 139843 318161 29114512
Chronic lymphocytic leukaemia 67.14 11.81 85 141769 3548 29429125
Drug withdrawal syndrome 67.04 11.81 5 141849 17979 29414694
Pseudomonas infection 66.22 11.81 155 141699 10697 29421976
Posterior reversible encephalopathy syndrome 65.83 11.81 138 141716 8838 29423835
Dehydration 65.56 11.81 305 141549 114443 29318230
Hyperkalaemia 65.07 11.81 122 141732 61270 29371403
Treatment noncompliance 64.67 11.81 18 141836 24209 29408464
End stage renal disease 63.55 11.81 124 141730 7540 29425133
Drug ineffective for unapproved indication 62.97 11.81 180 141674 14034 29418639
Hepatitis E 62.76 11.81 57 141797 1617 29431056
Insomnia 62.65 11.81 217 141637 88544 29344129
Pneumonitis 62.08 11.81 283 141571 27761 29404912
Irritability 61.92 11.81 15 141839 22137 29410536
B-cell lymphoma refractory 61.85 11.81 24 141830 120 29432553
Dyskinesia 61.39 11.81 11 141843 20050 29412623
Diabetic ketoacidosis 61.28 11.81 4 141850 16069 29416604
Cardiac arrest 61.26 11.81 208 141646 85383 29347290
Stress 61.16 11.81 14 141840 21476 29411197
Haemolysis 60.69 11.81 115 141739 6841 29425832
Cardiac failure congestive 59.05 11.81 180 141674 76401 29356272
Foot deformity 59.00 11.81 84 141770 3931 29428742
Intervertebral disc space narrowing 58.99 11.81 40 141814 730 29431943
Terminal state 58.72 11.81 78 141776 3416 29429257
Venoocclusive liver disease 58.68 11.81 113 141741 6804 29425869
Hepatic failure 58.26 11.81 302 141552 31210 29401463
Acute kidney injury 58.15 11.81 909 140945 264358 29168315
Coombs positive haemolytic anaemia 57.46 11.81 39 141815 713 29431960
Lethargy 56.54 11.81 58 141796 37522 29395151
Nausea 55.98 11.81 1014 140840 288241 29144432
Respiratory arrest 55.80 11.81 27 141827 25806 29406867
Humoral immune defect 55.07 11.81 19 141835 63 29432610
Microsporidia infection 54.82 11.81 34 141820 529 29432144
Unevaluable event 54.81 11.81 38 141816 29813 29402860
Medication error 54.35 11.81 17 141837 21194 29411479
Interstitial lung disease 54.15 11.81 467 141387 57251 29375422
Hallucination, visual 53.70 11.81 5 141849 15010 29417663
Malaise 53.23 11.81 499 141355 159103 29273570
Gastrointestinal haemorrhage 53.10 11.81 199 141655 79334 29353339
Encephalitis enteroviral 53.00 11.81 22 141832 135 29432538
Psoriasis 52.86 11.81 46 141808 32181 29400492
C-reactive protein abnormal 52.08 11.81 104 141750 6432 29426241
Lymphocytosis 52.03 11.81 55 141799 1885 29430788
Injury 51.12 11.81 14 141840 19032 29413641
Abnormal behaviour 50.22 11.81 24 141830 23103 29409570
Tooth loss 49.82 11.81 74 141780 3600 29429073
Synovial cyst 49.50 11.81 53 141801 1844 29430829
Cytology abnormal 48.98 11.81 28 141826 372 29432301
Drug resistance 48.89 11.81 219 141635 21321 29411352
Disorientation 48.57 11.81 42 141812 29473 29403200
Deep vein thrombosis 48.51 11.81 454 141400 56945 29375728
Blood pressure systolic increased 48.27 11.81 184 141670 16661 29416012
Bladder transitional cell carcinoma 47.75 11.81 59 141795 2402 29430271
Rheumatoid factor positive 47.62 11.81 33 141821 625 29432048
Osteosclerosis 47.45 11.81 41 141813 1087 29431586
JC polyomavirus test positive 46.72 11.81 31 141823 545 29432128
Oedema peripheral 46.60 11.81 298 141556 103259 29329414
Restlessness 46.54 11.81 24 141830 22121 29410552
Labelled drug-drug interaction medication error 46.43 11.81 3 141851 12156 29420517
Hyperpyrexia 45.82 11.81 56 141798 2254 29430419
Immunosuppression 45.64 11.81 87 141767 5199 29427474
Erectile dysfunction 45.14 11.81 15 141839 17994 29414679
Depressed level of consciousness 45.08 11.81 67 141787 36875 29395798
Product prescribing error 45.01 11.81 15 141839 17961 29414712
Angioedema 44.97 11.81 52 141802 31863 29400810
B-cell lymphoma 44.90 11.81 72 141782 3746 29428927
Haematemesis 44.35 11.81 32 141822 24594 29408079
Dysgeusia 44.16 11.81 27 141827 22647 29410026
Incorrect dose administered 44.09 11.81 56 141798 32928 29399745
Gamma-glutamyltransferase increased 44.05 11.81 38 141816 26699 29405974
Therapy non-responder 43.83 11.81 276 141578 30635 29402038
Delirium 43.79 11.81 76 141778 39321 29393352
Vision blurred 43.31 11.81 79 141775 40097 29392576
Nightmare 43.06 11.81 3 141851 11414 29421259
Abdominal distension 42.92 11.81 98 141756 45813 29386860
Chest pain 42.69 11.81 338 141516 111635 29321038
Melaena 42.64 11.81 52 141802 31124 29401549
Lymphadenitis 42.11 11.81 45 141809 1562 29431111
Asthenia 42.06 11.81 753 141101 214497 29218176
Mantle cell lymphoma refractory 41.89 11.81 16 141838 76 29432597
Therapeutic product effect decreased 41.78 11.81 263 141591 29188 29403485
Haemophagocytic lymphohistiocytosis 41.75 11.81 128 141726 10376 29422297
Intestinal sepsis 41.30 11.81 26 141828 416 29432257
Withdrawal syndrome 41.13 11.81 3 141851 10989 29421684
5q minus syndrome 41.02 11.81 18 141836 129 29432544
Sopor 40.87 11.81 3 141851 10931 29421742
Depressed mood 40.70 11.81 14 141840 16434 29416239
Candida infection 40.13 11.81 162 141692 15063 29417610
Immune thrombocytopenia 40.12 11.81 105 141749 7772 29424901
Joint arthroplasty 39.99 11.81 30 141824 646 29432027
Lung infiltration 39.99 11.81 136 141718 11643 29421030
Neoplasm progression 39.84 11.81 186 141668 18426 29414247
Arthritis bacterial 39.80 11.81 74 141780 4339 29428334
Pancreatitis acute 39.76 11.81 35 141819 24350 29408323
Lactic acidosis 39.76 11.81 52 141802 30195 29402478
Adverse drug reaction 39.74 11.81 34 141820 23986 29408687
Babesiosis 39.58 11.81 14 141840 51 29432622
Polyneuropathy 39.25 11.81 138 141716 12014 29420659
Cerebral aspergillosis 39.17 11.81 40 141814 1316 29431357
Blood glucose increased 39.09 11.81 148 141706 58836 29373837
Mantle cell lymphoma 39.08 11.81 37 141817 1108 29431565
Chronic lymphocytic leukaemia refractory 38.82 11.81 15 141839 74 29432599
Liver function test abnormal 38.75 11.81 49 141805 28869 29403804
Meningitis cryptococcal 38.60 11.81 49 141805 2051 29430622
Ventricular tachycardia 38.53 11.81 31 141823 22543 29410130
Blood urea increased 38.33 11.81 47 141807 28065 29404608
Pain in extremity 38.20 11.81 342 141512 110091 29322582
Prerenal failure 38.18 11.81 45 141809 1743 29430930
Therapy cessation 38.12 11.81 11 141843 14451 29418222
Graft versus host disease 37.96 11.81 117 141737 9511 29423162
Blood immunoglobulin A decreased 37.86 11.81 20 141834 225 29432448
Drug tolerance decreased 37.60 11.81 39 141815 1307 29431366
Unresponsive to stimuli 37.54 11.81 39 141815 25087 29407586
Extravasation 37.23 11.81 43 141811 1629 29431044
Pulmonary fibrosis 36.55 11.81 160 141694 15422 29417251
Tooth fracture 36.41 11.81 59 141795 3097 29429576
Orthostatic hypotension 36.27 11.81 33 141821 22596 29410077
Prostatic specific antigen increased 36.12 11.81 8 141846 12556 29420117
Disability 36.07 11.81 71 141783 4345 29428328
Epstein-Barr virus infection reactivation 36.04 11.81 26 141828 526 29432147
Scleroderma 36.01 11.81 38 141816 1300 29431373
Pneumonia fungal 35.78 11.81 83 141771 5694 29426979
Dystonia 35.53 11.81 3 141851 9746 29422927
Cerebral haemorrhage 35.49 11.81 60 141794 31366 29401307
Sweat gland tumour 35.43 11.81 23 141831 389 29432284
Pancreatitis 35.33 11.81 70 141784 34444 29398229
Gastritis bacterial 35.23 11.81 18 141836 188 29432485
Glomerulonephritis 35.00 11.81 42 141812 1658 29431015
Blood immunoglobulin G decreased 34.96 11.81 35 141819 1124 29431549
Immunoglobulins decreased 34.61 11.81 28 141826 676 29431997
Emotional distress 34.08 11.81 12 141842 13883 29418790
Bone marrow infiltration 34.01 11.81 15 141839 109 29432564
Mental status changes 33.92 11.81 73 141781 34854 29397819
Dry skin 33.90 11.81 37 141817 23270 29409403
Sleep disorder due to general medical condition, insomnia type 33.87 11.81 36 141818 1242 29431431
Encephalitis viral 33.81 11.81 34 141820 1098 29431575
Osteoarthritis 33.80 11.81 174 141680 17929 29414744
Haemoglobin abnormal 33.65 11.81 57 141797 3104 29429569
Central nervous system lymphoma 33.58 11.81 28 141826 706 29431967
Secondary immunodeficiency 33.46 11.81 21 141833 334 29432339
Psychotic disorder 33.44 11.81 29 141825 20325 29412348
Neutropenic infection 33.20 11.81 36 141818 1271 29431402
Pneumonia adenoviral 33.18 11.81 16 141838 146 29432527
Drug dependence 33.15 11.81 31 141823 20950 29411723
Enterococcal infection 33.09 11.81 101 141753 8167 29424506
Abdominal pain 32.98 11.81 454 141400 134903 29297770
Polyarthritis 32.92 11.81 64 141790 3881 29428792
Cytomegalovirus test positive 32.89 11.81 59 141795 3364 29429309
Temperature intolerance 32.87 11.81 54 141800 2867 29429806
Intestinal perforation 32.57 11.81 99 141755 7987 29424686
Delusion 32.53 11.81 7 141847 11209 29421464
Haematochezia 32.15 11.81 82 141772 36901 29395772
Platelet count abnormal 32.14 11.81 48 141806 2346 29430327
Throat irritation 32.11 11.81 104 141750 8681 29423992
Faeces discoloured 31.95 11.81 12 141842 13339 29419334
Hand deformity 31.94 11.81 45 141809 2085 29430588
Gait inability 31.65 11.81 25 141829 18350 29414323
Injection site swelling 31.48 11.81 4 141850 9413 29423260
Muscle rigidity 31.45 11.81 4 141850 9407 29423266
Viral haemorrhagic cystitis 31.37 11.81 30 141824 910 29431763
Dyspnoea 31.32 11.81 1266 140588 325466 29107207
Herpes simplex encephalitis 31.18 11.81 19 141835 286 29432387
Hypoaesthesia 31.16 11.81 141 141713 53326 29379347
Adenovirus infection 31.02 11.81 67 141787 4380 29428293
Sleep disorder 30.96 11.81 43 141811 24343 29408330
Paraesthesia 30.78 11.81 143 141711 53702 29378971
Mucormycosis 30.74 11.81 73 141781 5085 29427588
Amnesia 30.72 11.81 38 141816 22605 29410068
Hypokalaemia 30.71 11.81 130 141724 50073 29382600
BK virus infection 30.67 11.81 69 141785 4638 29428035
Bacteraemia 30.55 11.81 157 141697 16166 29416507
Aspartate aminotransferase increased 30.49 11.81 165 141689 59560 29373113
Head injury 30.15 11.81 20 141834 16061 29416612
Congenital cardiovascular anomaly 30.06 11.81 16 141838 183 29432490
Neoplasm recurrence 29.99 11.81 42 141812 1935 29430738
Pseudomonal sepsis 29.94 11.81 52 141802 2890 29429783
Blood alkaline phosphatase increased 29.60 11.81 57 141797 28349 29404324
Product quality issue 29.49 11.81 20 141834 15875 29416798
Disseminated cytomegaloviral infection 29.33 11.81 16 141838 193 29432480
Rhinovirus infection 29.09 11.81 54 141800 3162 29429511
Disturbance in attention 29.02 11.81 36 141818 21388 29411285
Paraneoplastic pemphigus 29.02 11.81 11 141843 51 29432622
Cytomegalovirus viraemia 28.93 11.81 81 141773 6239 29426434
Periostitis 28.84 11.81 17 141837 240 29432433
Cytomegalovirus gastritis 28.69 11.81 16 141838 202 29432471
Psychomotor hyperactivity 28.67 11.81 3 141851 8210 29424463
Therapeutic response decreased 28.67 11.81 210 141644 24501 29408172
Immunodeficiency common variable 28.55 11.81 14 141840 133 29432540
Cystitis viral 28.54 11.81 22 141832 494 29432179
Wrist deformity 28.49 11.81 19 141835 337 29432336
Prescribed overdose 28.28 11.81 4 141850 8679 29423994
Respiratory failure 28.26 11.81 637 141217 96494 29336179
Pneumonia escherichia 28.10 11.81 19 141835 345 29432328
Acute myocardial infarction 28.07 11.81 128 141726 48310 29384363
Asthma 27.94 11.81 77 141777 33772 29398901
Balance disorder 27.87 11.81 85 141769 36085 29396588
Miosis 27.77 11.81 3 141851 8006 29424667
Exposure during pregnancy 27.72 11.81 4 141850 8550 29424123
Hip fracture 27.62 11.81 8 141846 10484 29422189
Erysipelas 27.60 11.81 62 141792 4163 29428510
Hyperglycaemia 27.56 11.81 79 141775 34208 29398465
Thrombotic microangiopathy 27.53 11.81 98 141756 8583 29424090
Dysarthria 27.28 11.81 68 141786 30843 29401830
Enterovirus infection 27.26 11.81 24 141830 653 29432020
Post procedural complication 27.20 11.81 8 141846 10381 29422292
Encephalitis cytomegalovirus 27.19 11.81 21 141833 473 29432200
Escherichia sepsis 26.98 11.81 59 141795 3890 29428783
Autoimmune lymphoproliferative syndrome 26.93 11.81 14 141840 152 29432521
Neuroborreliosis 26.76 11.81 9 141845 27 29432646
Epstein-Barr viraemia 26.72 11.81 28 141826 950 29431723
Injection site erythema 26.65 11.81 17 141837 13939 29418734
Intestinal obstruction 26.52 11.81 32 141822 19245 29413428
Respiratory depression 26.48 11.81 16 141838 13507 29419166
Infective exacerbation of chronic obstructive airways disease 26.45 11.81 36 141818 1614 29431059
Vasculitis 26.44 11.81 91 141763 7837 29424836
Human rhinovirus test positive 26.39 11.81 14 141840 159 29432514
Underdose 26.25 11.81 12 141842 11857 29420816
Lymphocyte count decreased 26.04 11.81 170 141684 19101 29413572
Hyperlipidaemia 25.93 11.81 14 141840 12576 29420097
Pulmonary toxicity 25.74 11.81 66 141788 4824 29427849
Hypocalcaemia 25.67 11.81 37 141817 20628 29412045
Hypotension 25.62 11.81 723 141131 193631 29239042
Osteonecrosis of jaw 25.38 11.81 25 141829 16485 29416188
Device malfunction 25.31 11.81 5 141849 8502 29424171
Chronic lymphocytic leukaemia transformation 25.16 11.81 14 141840 176 29432497
Blood potassium decreased 25.15 11.81 23 141831 15711 29416962
SARS-CoV-2 antibody test negative 25.12 11.81 7 141847 8 29432665
Blood pressure diastolic increased 25.11 11.81 55 141799 3631 29429042
Pseudomonal bacteraemia 25.09 11.81 27 141827 945 29431728
Fluid retention 24.79 11.81 47 141807 23513 29409160
Pneumonia klebsiella 24.68 11.81 45 141809 2599 29430074
Cardiomegaly 24.68 11.81 18 141836 13758 29418915
Prothrombin time prolonged 24.64 11.81 6 141848 8826 29423847
Abdominal lymphadenopathy 24.62 11.81 23 141831 677 29431996
Blood lactate dehydrogenase increased 24.48 11.81 167 141687 19042 29413631
Frequent bowel movements 24.40 11.81 7 141847 9232 29423441
Acute lung injury 24.34 11.81 31 141823 1302 29431371
Altered state of consciousness 24.33 11.81 36 141818 19853 29412820
Nervousness 24.14 11.81 12 141842 11294 29421379
Blood glucose decreased 24.02 11.81 14 141840 12055 29420618
Cystitis escherichia 23.74 11.81 13 141841 158 29432515
Abdominal pain upper 23.74 11.81 183 141671 60810 29371863
Flatulence 23.73 11.81 30 141824 17679 29414994
Cardiac disorder 23.72 11.81 95 141759 37168 29395505
Chronic allograft nephropathy 23.60 11.81 28 141826 1092 29431581
Rib fracture 23.60 11.81 16 141838 12702 29419971
B-cell aplasia 23.43 11.81 11 141843 94 29432579
Road traffic accident 23.42 11.81 24 141830 15537 29417136
Hepatitis B surface antigen positive 23.19 11.81 12 141842 129 29432544
Human herpesvirus 6 infection 23.10 11.81 36 141818 1827 29430846
Tumour flare 23.09 11.81 20 141834 532 29432141
Haemolytic anaemia 23.08 11.81 98 141756 9321 29423352
Myoclonus 23.06 11.81 18 141836 13291 29419382
Splenomegaly 22.99 11.81 125 141729 13154 29419519
Hypomagnesaemia 22.98 11.81 30 141824 17438 29415235
Human polyomavirus infection 22.96 11.81 22 141832 669 29432004
Chronic graft versus host disease 22.91 11.81 56 141798 3973 29428700
Diaphragm muscle weakness 22.87 11.81 12 141842 133 29432540
Swelling face 22.84 11.81 39 141815 20311 29412362
Salivary hypersecretion 22.80 11.81 4 141850 7405 29425268
Anger 22.59 11.81 12 141842 10878 29421795
Nasal cavity cancer 22.49 11.81 12 141842 138 29432535
Post-acute COVID-19 syndrome 22.44 11.81 8 141846 30 29432643
Burning sensation 22.42 11.81 26 141828 15912 29416761
Atrial septal defect 22.41 11.81 3 141851 6786 29425887
Medical device implantation 22.38 11.81 20 141834 555 29432118
Hallucination, auditory 22.33 11.81 9 141845 9584 29423089
Cellulitis gangrenous 22.27 11.81 13 141841 180 29432493
Incorrect route of product administration 22.26 11.81 12 141842 10789 29421884
Granuloma skin 22.23 11.81 21 141833 627 29432046
Lung adenocarcinoma 22.19 11.81 54 141800 3821 29428852
West Nile viral infection 22.18 11.81 21 141833 629 29432044
Mood swings 22.13 11.81 4 141850 7247 29425426
Central nervous system fungal infection 22.13 11.81 16 141838 325 29432348
Refractory anaemia with an excess of blasts 22.12 11.81 17 141837 380 29432293
Lymphoplasmacytoid lymphoma/immunocytoma 22.04 11.81 8 141846 32 29432641
Blood immunoglobulin M increased 22.03 11.81 13 141841 184 29432489
Abscess 21.96 11.81 99 141755 9663 29423010
Hyperthyroidism 21.87 11.81 7 141847 8601 29424072
Neurological decompensation 21.85 11.81 41 141813 2421 29430252
Musculoskeletal stiffness 21.76 11.81 275 141579 37183 29395490
Lung opacity 21.76 11.81 30 141824 1362 29431311
Fluoride increased 21.71 11.81 9 141845 55 29432618
Gastric stenosis 21.66 11.81 8 141846 34 29432639
Hypophagia 21.64 11.81 42 141812 20830 29411843
Myocardial ischaemia 21.64 11.81 27 141827 16001 29416672
Atypical pneumonia 21.62 11.81 42 141812 2545 29430128
Product administration error 21.61 11.81 22 141832 14288 29418385
Neck pain 21.51 11.81 44 141810 21403 29411270
Mass 21.47 11.81 79 141775 7032 29425641
Systemic mycosis 21.45 11.81 29 141825 1292 29431381
Ear pruritus 21.42 11.81 15 141839 289 29432384
CD4 lymphocytes decreased 21.40 11.81 32 141822 1566 29431107
Disorder of orbit 21.34 11.81 10 141844 85 29432588
Cardiogenic shock 21.34 11.81 37 141817 19153 29413520
Febrile infection 21.15 11.81 36 141818 1968 29430705
Strongyloidiasis 21.14 11.81 39 141815 2273 29430400
Epistaxis 21.13 11.81 153 141701 51551 29381122
Acquired C1 inhibitor deficiency 21.02 11.81 6 141848 8 29432665
Microscopic polyangiitis 20.96 11.81 11 141843 122 29432551
Meningitis tuberculous 20.96 11.81 20 141834 605 29432068
Human herpesvirus 8 infection 20.94 11.81 23 141831 824 29431849
Small intestinal perforation 20.89 11.81 32 141822 1600 29431073
Traumatic lung injury 20.85 11.81 27 141827 1153 29431520
Back pain 20.82 11.81 355 141499 101929 29330744
Antineutrophil cytoplasmic antibody increased 20.81 11.81 7 141847 21 29432652
Rebound effect 20.80 11.81 36 141818 1995 29430678
Skin discolouration 20.75 11.81 26 141828 15383 29417290
Hypersomnia 20.67 11.81 13 141841 10741 29421932
Device related infection 20.56 11.81 137 141717 15499 29417174
Cryptococcosis 20.52 11.81 35 141819 1917 29430756
Cerebral infarction 20.46 11.81 56 141798 24619 29408054
Transplant rejection 20.41 11.81 93 141761 9119 29423554
Limb deformity 20.37 11.81 18 141836 492 29432181
Graft versus host disease in skin 20.33 11.81 48 141806 3331 29429342
Upper gastrointestinal haemorrhage 20.29 11.81 47 141807 21867 29410806
Bacterial sepsis 20.29 11.81 59 141795 4644 29428029
Gene mutation 20.27 11.81 25 141829 1016 29431657
Isosporiasis 20.22 11.81 9 141845 67 29432606
Chromaturia 20.12 11.81 19 141835 12783 29419890
Hip arthroplasty 20.07 11.81 51 141803 3707 29428966
Eating disorder 20.07 11.81 5 141849 7242 29425431
Klebsiella infection 20.01 11.81 79 141775 7270 29425403
Dry mouth 19.95 11.81 47 141807 21737 29410936
T-lymphocyte count decreased 19.90 11.81 12 141842 177 29432496
Pulmonary sarcoidosis 19.86 11.81 18 141836 509 29432164
Iron deficiency anaemia 19.84 11.81 9 141845 8933 29423740
Presyncope 19.80 11.81 29 141825 16060 29416613
Speech disorder 19.78 11.81 53 141801 23463 29409210
Intestinal atresia 19.67 11.81 9 141845 72 29432601
Pneumonia aspiration 19.58 11.81 100 141754 36637 29396036
Noninfectious myelitis 19.53 11.81 6 141848 12 29432661
Heart rate decreased 19.53 11.81 194 141660 24718 29407955
Escherichia infection 19.47 11.81 74 141780 6690 29425983
Antineutrophil cytoplasmic antibody positive 19.45 11.81 19 141835 592 29432081
Generalised tonic-clonic seizure 19.42 11.81 39 141815 19100 29413573
Visual impairment 19.37 11.81 75 141779 29633 29403040
Tricuspid valve incompetence 19.34 11.81 8 141846 8386 29424287
Dermatitis exfoliative generalised 19.28 11.81 43 141811 2873 29429800
Marginal zone lymphoma recurrent 19.28 11.81 7 141847 28 29432645
Neutrophil Pelger-Huet anomaly present 19.28 11.81 13 141841 235 29432438
Urinary retention 19.25 11.81 83 141771 31815 29400858
Blood stem cell transplant failure 19.24 11.81 16 141838 402 29432271
Device related thrombosis 19.23 11.81 23 141831 905 29431768
Infusion site discolouration 19.20 11.81 10 141844 109 29432564
Adenovirus reactivation 19.13 11.81 10 141844 110 29432563
Mental impairment 19.07 11.81 10 141844 9131 29423542
Postural tremor 18.96 11.81 14 141840 294 29432379
Oedema 18.96 11.81 115 141739 40368 29392305
Pulmonary congestion 18.92 11.81 19 141835 12417 29420256
Lip swelling 18.83 11.81 19 141835 12391 29420282
Mania 18.79 11.81 9 141845 8654 29424019
Follicular lymphoma 18.72 11.81 7 141847 31 29432642
Cryoglobulinaemia 18.72 11.81 14 141840 300 29432373
Jejunal perforation 18.69 11.81 12 141842 199 29432474
Glycosylated haemoglobin increased 18.67 11.81 11 141843 9415 29423258
Inappropriate antidiuretic hormone secretion 18.67 11.81 15 141839 10917 29421756
Fungal infection 18.66 11.81 121 141733 13564 29419109
Feeling abnormal 18.63 11.81 169 141685 54276 29378397
Device issue 18.61 11.81 7 141847 7773 29424900
Neuropathy peripheral 18.56 11.81 459 141395 70568 29362105
Ecthyma 18.54 11.81 15 141839 362 29432311
Neurofibrosarcoma 18.54 11.81 7 141847 32 29432641
Electrocardiogram abnormal 18.52 11.81 6 141848 7316 29425357
Pneumonia viral 18.52 11.81 40 141814 2615 29430058
Morphoea 18.44 11.81 11 141843 159 29432514
Bone marrow reticulin fibrosis 18.44 11.81 11 141843 159 29432514
Chylothorax 18.39 11.81 19 141835 634 29432039
Glomerulonephritis rapidly progressive 18.38 11.81 17 141837 494 29432179
Hepatitis D 18.37 11.81 7 141847 33 29432640
B-lymphocyte count increased 18.35 11.81 6 141848 16 29432657
Parkinsonism 18.35 11.81 6 141848 7272 29425401
Ageusia 18.32 11.81 10 141844 8928 29423745
Contusion 18.11 11.81 82 141772 31013 29401660
Granulomatosis with polyangiitis 18.03 11.81 22 141832 884 29431789
Hepatic amoebiasis 17.93 11.81 8 141846 60 29432613
Drug level decreased 17.91 11.81 4 141850 6243 29426430
Rectal haemorrhage 17.88 11.81 95 141759 34454 29398219
Peripheral coldness 17.87 11.81 4 141850 6232 29426441
Infection reactivation 17.86 11.81 24 141830 1063 29431610
Chronic kidney disease 17.82 11.81 102 141752 36314 29396359
Sudden death 17.79 11.81 25 141829 14085 29418588
Palmar-plantar erythrodysaesthesia syndrome 17.77 11.81 27 141827 14732 29417941
Transient ischaemic attack 17.70 11.81 55 141799 23215 29409458
Adenoviral haemorrhagic cystitis 17.67 11.81 15 141839 388 29432285
Engraftment syndrome 17.64 11.81 21 141833 822 29431851
Encephalitis Japanese B 17.60 11.81 6 141848 19 29432654
Pneumonia bacterial 17.58 11.81 90 141764 9253 29423420
Central nervous system infection 17.52 11.81 17 141837 525 29432148
Hepatic infection fungal 17.47 11.81 11 141843 176 29432497
Hypertension 17.40 11.81 426 141428 116188 29316485
Hairy cell leukaemia recurrent 17.38 11.81 4 141850 0 29432673
Device occlusion 17.32 11.81 3 141851 5605 29427068
Metastases to bone marrow 17.27 11.81 16 141838 466 29432207
Mydriasis 17.24 11.81 4 141850 6081 29426592
Ventricular fibrillation 17.17 11.81 31 141823 15802 29416871
Granulocytopenia neonatal 17.14 11.81 6 141848 21 29432652
Sensitivity to weather change 17.01 11.81 27 141827 1392 29431281
Thirst 16.99 11.81 5 141849 6486 29426187
Vocal cord paralysis 16.95 11.81 21 141833 857 29431816
Squamous cell carcinoma of skin 16.90 11.81 90 141764 9396 29423277
Prostatic abscess 16.89 11.81 15 141839 413 29432260
Organising pneumonia 16.88 11.81 58 141796 4990 29427683
Superior mesenteric artery syndrome 16.88 11.81 8 141846 70 29432603
Central nervous system enteroviral infection 16.86 11.81 7 141847 43 29432630
Blood sodium decreased 16.85 11.81 28 141826 14739 29417934
Pleural effusion 16.84 11.81 458 141396 71450 29361223
Viral load increased 16.80 11.81 33 141821 2016 29430657
Epstein-Barr virus associated lymphoproliferative disorder 16.76 11.81 30 141824 1708 29430965
Primary amyloidosis 16.61 11.81 9 141845 107 29432566
Cytomegalovirus enterocolitis 16.60 11.81 20 141834 793 29431880
Stomatitis 16.53 11.81 260 141594 36853 29395820
Alanine aminotransferase increased 16.53 11.81 240 141614 70704 29361969
Rheumatoid factor 16.49 11.81 8 141846 74 29432599
Chronic graft versus host disease in skin 16.40 11.81 20 141834 803 29431870
Herpes virus infection 16.38 11.81 37 141817 2494 29430179
Pulmonary hypertension 16.37 11.81 41 141813 18567 29414106
Haemorrhage 16.26 11.81 138 141716 44934 29387739
Diabetes mellitus 16.21 11.81 118 141736 39713 29392960
Swollen tongue 16.21 11.81 21 141833 12245 29420428
Bacterial infection 16.16 11.81 112 141742 12836 29419837
Adenocarcinoma gastric 16.09 11.81 23 141831 1080 29431593
Left ventricular hypertrophy 16.08 11.81 6 141848 6697 29425976
Blood immunoglobulin M decreased 16.08 11.81 14 141840 375 29432298
Drug level increased 16.06 11.81 42 141812 18745 29413928
Gastrosplenic fistula 15.97 11.81 6 141848 27 29432646
Right ventricular failure 15.92 11.81 9 141845 7881 29424792
Colitis 15.91 11.81 224 141630 31024 29401649
Neoplasm 15.88 11.81 50 141804 4111 29428562
Pulmonary mass 15.87 11.81 97 141757 10651 29422022
Cytomegalovirus colitis 15.87 11.81 36 141818 2433 29430240
Infective thrombosis 15.74 11.81 7 141847 52 29432621
Colitis ulcerative 15.73 11.81 23 141831 12746 29419927
Psoriatic arthropathy 15.72 11.81 29 141825 14662 29418011
Accidental exposure to product 15.71 11.81 17 141837 10736 29421937
Transformation to acute myeloid leukaemia 15.69 11.81 18 141836 677 29431996
Cytokine storm 15.68 11.81 17 141837 600 29432073
Multiple sclerosis relapse 15.66 11.81 19 141835 11400 29421273
Phlebitis infective 15.65 11.81 9 141845 121 29432552
Poisoning 15.51 11.81 15 141839 9978 29422695
Hepatitis C RNA increased 15.47 11.81 12 141842 272 29432401
Obstructive airways disorder 15.46 11.81 18 141836 10998 29421675
Foetal exposure during pregnancy 15.44 11.81 97 141757 33770 29398903
Positron emission tomogram abnormal 15.40 11.81 9 141845 125 29432548
Dyspnoea exertional 15.39 11.81 107 141747 36383 29396290
Acute respiratory distress syndrome 15.35 11.81 173 141681 22762 29409911
Meningoencephalitis viral 15.33 11.81 9 141845 126 29432547
Lymphoproliferative disorder 15.31 11.81 36 141818 2491 29430182
Increased appetite 15.28 11.81 5 141849 6059 29426614
Cytomegalovirus oesophagitis 15.27 11.81 14 141840 402 29432271
Wheezing 15.26 11.81 95 141759 33145 29399528
Arteriosclerosis coronary artery 15.24 11.81 17 141837 10588 29422085
Headache 15.18 11.81 681 141173 173326 29259347
Nocardiosis 15.14 11.81 42 141812 3218 29429455
Pollakiuria 15.09 11.81 37 141817 16879 29415794
Obesity 15.08 11.81 15 141839 9848 29422825
Blood loss anaemia 15.08 11.81 8 141846 7258 29425415
Dialysis 15.07 11.81 16 141838 10192 29422481
Varicella 15.07 11.81 26 141828 1437 29431236
Blood pressure increased 15.06 11.81 462 141392 73341 29359332
Full blood count decreased 15.05 11.81 34 141820 15958 29416715
Viral cardiomyopathy 15.00 11.81 6 141848 33 29432640
Hypercholesterolaemia 14.98 11.81 8 141846 7230 29425443
Therapy interrupted 14.96 11.81 11 141843 8375 29424298
Back disorder 14.92 11.81 5 141849 5968 29426705
Acute hepatitis B 14.91 11.81 9 141845 133 29432540
Hemianopia 14.89 11.81 17 141837 636 29432037
Nervous system disorder 14.87 11.81 108 141746 12566 29420107
Coxsackie viral infection 14.86 11.81 5 141849 15 29432658
Gallbladder adenocarcinoma 14.86 11.81 5 141849 15 29432658
Suspected product quality issue 14.85 11.81 9 141845 134 29432539
Anorectal varices 14.85 11.81 6 141848 34 29432639
Mucocutaneous haemorrhage 14.84 11.81 8 141846 94 29432579
Dysstasia 14.82 11.81 17 141837 10457 29422216
Adverse event 14.81 11.81 32 141822 15259 29417414
Anti-cyclic citrullinated peptide antibody positive 14.79 11.81 19 141835 805 29431868
Haemoptysis 14.72 11.81 86 141768 30464 29402209
Injection site mass 14.65 11.81 4 141850 5451 29427222
Tooth infection 14.64 11.81 59 141795 5480 29427193
Seronegative arthritis 14.57 11.81 20 141834 904 29431769
Soft tissue disorder 14.49 11.81 17 141837 655 29432018
Injection site pruritus 14.43 11.81 5 141849 5844 29426829
Blood HIV RNA increased 14.42 11.81 21 141833 1003 29431670
Metastases to spleen 14.36 11.81 13 141841 367 29432306
Ureaplasma infection 14.36 11.81 10 141844 191 29432482
Crystal nephropathy 14.33 11.81 13 141841 368 29432305
Immune effector cell-associated neurotoxicity syndrome 14.30 11.81 26 141828 1498 29431175
Discomfort 14.21 11.81 31 141823 14732 29417941
Paresis 14.17 11.81 29 141825 1825 29430848
Bone disorder 14.17 11.81 5 141849 5778 29426895
Foetal growth restriction 14.14 11.81 45 141809 3721 29428952
Empyema 14.11 11.81 37 141817 2742 29429931
Metastases to bone 14.08 11.81 16 141838 9882 29422791
Cutaneous T-cell lymphoma recurrent 14.04 11.81 6 141848 40 29432633
Cardiomyopathy 14.04 11.81 120 141734 14667 29418006
Activated partial thromboplastin time prolonged 14.02 11.81 10 141844 7732 29424941
Mood altered 14.01 11.81 11 141843 8100 29424573
Cushingoid 13.98 11.81 34 141820 2404 29430269
Glottis carcinoma 13.97 11.81 5 141849 19 29432654
Atypical fibroxanthoma 13.96 11.81 10 141844 200 29432473
Scedosporium infection 13.93 11.81 18 141836 767 29431906
Urticaria 13.91 11.81 352 141502 54308 29378365
Pruritus 13.80 11.81 441 141413 116408 29316265
Helicobacter sepsis 13.77 11.81 5 141849 20 29432653
Follicle centre lymphoma, follicular grade I, II, III recurrent 13.74 11.81 4 141850 6 29432667
Recurrent cancer 13.74 11.81 22 141832 1143 29431530
Cardiotoxicity 13.73 11.81 52 141802 4692 29427981
Hepatitis fulminant 13.71 11.81 43 141811 3528 29429145
Splenic candidiasis 13.71 11.81 7 141847 73 29432600
Rheumatoid factor increased 13.66 11.81 15 141839 537 29432136
Viraemia 13.66 11.81 21 141833 1053 29431620
Angiosarcoma 13.65 11.81 11 141843 264 29432409
Lung disorder 13.63 11.81 213 141641 30149 29402524
Coronary artery occlusion 13.63 11.81 17 141837 10077 29422596
Dyslipidaemia 13.61 11.81 6 141848 6055 29426618
Cholelithiasis 13.60 11.81 45 141809 18627 29414046
Non-Hodgkin's lymphoma recurrent 13.58 11.81 5 141849 21 29432652
Tenderness 13.58 11.81 59 141795 5668 29427005
Metastases to muscle 13.50 11.81 10 141844 211 29432462
Tooth disorder 13.45 11.81 85 141769 9444 29423229
Needle issue 13.42 11.81 3 141851 4680 29427993
Therapeutic response unexpected 13.37 11.81 13 141841 8625 29424048
Peripheral swelling 13.36 11.81 220 141634 63519 29369154
Eczema 13.33 11.81 29 141825 13797 29418876
Sphingomonas paucimobilis infection 13.33 11.81 6 141848 46 29432627
Oral pain 13.29 11.81 15 141839 9292 29423381
Metastases to retroperitoneum 13.26 11.81 10 141844 217 29432456
Neutrophil percentage decreased 13.19 11.81 12 141842 341 29432332
Myeloid leukaemia 13.16 11.81 12 141842 342 29432331
Hepatitis B DNA increased 13.15 11.81 14 141840 484 29432189
Myeloproliferative neoplasm 13.10 11.81 14 141840 486 29432187
Cerebral toxoplasmosis 13.09 11.81 24 141830 1392 29431281
Epstein-Barr virus associated lymphoma 13.06 11.81 15 141839 565 29432108
Interchange of vaccine products 13.03 11.81 3 141851 0 29432673
Hypoglobulinaemia 13.03 11.81 3 141851 0 29432673
Hepatitis B core antigen positive 13.03 11.81 3 141851 0 29432673
Larynx irritation 13.03 11.81 3 141851 0 29432673
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 13.02 11.81 4 141850 8 29432665
Enterococcal bacteraemia 12.95 11.81 25 141829 1508 29431165
Lacrimal duct neoplasm 12.89 11.81 5 141849 25 29432648
Mantle cell lymphoma stage III 12.89 11.81 5 141849 25 29432648
Retroperitoneal lymphadenopathy 12.88 11.81 17 141837 740 29431933
Abdominal abscess 12.84 11.81 44 141810 3780 29428893
Surgery 12.83 11.81 23 141831 11756 29420917
Blood pressure diastolic decreased 12.77 11.81 67 141787 6955 29425718
Adrenal insufficiency 12.75 11.81 21 141833 11093 29421580
Nasal congestion 12.74 11.81 47 141807 18832 29413841
Heparin-induced thrombocytopenia 12.74 11.81 4 141850 4975 29427698
Bone marrow disorder 12.73 11.81 25 141829 1527 29431146
Shock 12.73 11.81 56 141798 21348 29411325
Cardiac murmur 12.70 11.81 8 141846 6605 29426068
Hepatosplenomegaly 12.69 11.81 43 141811 3674 29428999
Pulmonary vasculitis 12.65 11.81 8 141846 129 29432544
Device leakage 12.65 11.81 3 141851 4492 29428181
Choking 12.63 11.81 3 141851 4488 29428185
Haematuria 12.62 11.81 143 141711 43996 29388677
Impaired work ability 12.54 11.81 57 141797 5583 29427090
Vaccination failure 12.51 11.81 14 141840 512 29432161
Muscle twitching 12.51 11.81 12 141842 8014 29424659
Refractory cytopenia with multilineage dysplasia 12.49 11.81 8 141846 132 29432541
Atrioventricular block complete 12.46 11.81 12 141842 7999 29424674
Disseminated blastomycosis 12.44 11.81 7 141847 90 29432583
Viral myelitis 12.42 11.81 5 141849 28 29432645
Splenic marginal zone lymphoma 12.42 11.81 5 141849 28 29432645
Basophilia 12.42 11.81 4 141850 10 29432663
Skin infection 12.37 11.81 63 141791 6464 29426209
Central nervous system vasculitis 12.33 11.81 12 141842 372 29432301
Necrotising soft tissue infection 12.32 11.81 6 141848 56 29432617
Respiratory tract infection 12.32 11.81 122 141732 15529 29417144
Tularaemia 12.31 11.81 7 141847 92 29432581
Candida pneumonia 12.29 11.81 11 141843 306 29432367
Abdominal wall abscess 12.17 11.81 13 141841 451 29432222
Oropharyngeal squamous cell carcinoma 12.15 11.81 9 141845 190 29432483
Non-Hodgkin's lymphoma 12.14 11.81 24 141830 1473 29431200
Volvulus of small bowel 12.14 11.81 5 141849 30 29432643
Diffuse large B-cell lymphoma stage III 12.06 11.81 6 141848 59 29432614
Injection site reaction 12.05 11.81 22 141832 11166 29421507
Streptococcal infection 12.02 11.81 48 141806 4440 29428233
Gynaecomastia 12.00 11.81 13 141841 8204 29424469
Combined immunodeficiency 11.97 11.81 6 141848 60 29432613
Red blood cell sedimentation rate 11.92 11.81 14 141840 540 29432133
Guillain-Barre syndrome 11.91 11.81 52 141802 5006 29427667
Leukoerythroblastosis 11.89 11.81 4 141850 12 29432661
Meningitis coccidioides 11.89 11.81 4 141850 12 29432661
Norovirus infection 11.89 11.81 4 141850 12 29432661
Phlebitis 11.88 11.81 41 141813 3535 29429138
Gastric disorder 11.87 11.81 90 141764 10614 29422059
X-ray abnormal 11.85 11.81 13 141841 465 29432208

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 2545.45 10.88 10346 351496 829901 63306989
Infusion related reaction 2209.13 10.88 3582 358260 160885 63976005
Drug intolerance 1991.95 10.88 3687 358155 184305 63952585
Off label use 1973.86 10.88 7873 353969 624933 63511957
Contraindicated product administered 1822.19 10.88 2614 359228 105215 64031675
Treatment failure 1532.88 10.88 2519 359323 114297 64022593
Progressive multifocal leukoencephalopathy 1438.48 10.88 1024 360818 17208 64119682
Joint swelling 1313.79 10.88 3382 358460 212000 63924890
Synovitis 1291.88 10.88 2131 359711 96959 64039931
Intentional product use issue 1285.38 10.88 2082 359760 93282 64043608
Febrile neutropenia 1268.73 10.88 3065 358777 184592 63952298
Completed suicide 1170.93 10.88 17 361825 224397 63912493
Hypogammaglobulinaemia 902.43 10.88 617 361225 9682 64127208
Drug interaction 899.01 10.88 455 361387 361628 63775262
Hand deformity 898.39 10.88 1409 360433 61362 64075528
Therapeutic product effect decreased 892.84 10.88 1988 359854 113363 64023527
Pemphigus 879.10 10.88 1370 360472 59331 64077559
Arthropathy 863.39 10.88 2019 359823 118948 64017942
Toxicity to various agents 807.83 10.88 523 361319 362990 63773900
Product use in unapproved indication 792.91 10.88 2484 359358 174134 63962756
Systemic lupus erythematosus 784.96 10.88 1494 360348 76118 64060772
Anti-cyclic citrullinated peptide antibody positive 749.03 10.88 1141 360701 48421 64088469
Diffuse large B-cell lymphoma recurrent 737.33 10.88 358 361484 2788 64134102
Hepatitis B 728.80 10.88 485 361357 7260 64129630
Drug abuse 723.85 10.88 3 361839 132371 64004519
Neutropenia 698.28 10.88 2927 358915 236697 63900193
Rheumatoid factor positive 686.92 10.88 912 360930 34026 64102864
Glossodynia 668.53 10.88 1257 360585 63439 64073451
Fall 611.21 10.88 870 360972 415956 63720934
Infection 586.39 10.88 2319 359523 182561 63954329
Pneumocystis jirovecii pneumonia 584.71 10.88 748 361094 26886 64110004
Product dose omission issue 583.71 10.88 183 361659 194564 63942326
Hepatitis B reactivation 546.00 10.88 341 361501 4548 64132342
Swelling 538.41 10.88 2047 359795 158171 63978719
Overdose 532.86 10.88 121 361721 159445 63977445
Pericarditis 518.08 10.88 1108 360734 61408 64075482
Hepatic enzyme increased 493.74 10.88 1728 360114 128215 64008675
Cytomegalovirus infection 485.53 10.88 801 361041 36398 64100492
Intentional overdose 481.59 10.88 4 361838 89940 64046950
Myelodysplastic syndrome 470.02 10.88 672 361170 26907 64109983
Alopecia 442.98 10.88 1973 359869 163717 63973173
Abdominal discomfort 432.21 10.88 2096 359746 180226 63956664
Wound 422.55 10.88 1159 360683 75318 64061572
Tumour lysis syndrome 420.39 10.88 532 361310 18908 64117982
Red blood cell sedimentation rate increased 417.66 10.88 680 361162 30555 64106335
Rhabdomyolysis 414.31 10.88 25 361817 91701 64045189
Dizziness 413.07 10.88 1150 360692 429013 63707877
Rheumatoid arthritis 412.10 10.88 1920 359922 162374 63974516
Helicobacter infection 394.47 10.88 744 361098 37618 64099272
Hypersensitivity 388.34 10.88 2147 359695 194305 63942585
Injection site pain 385.10 10.88 78 361764 111330 64025560
Vomiting 359.89 10.88 1730 360112 549387 63587503
Arthralgia 354.18 10.88 3914 357928 438346 63698544
Blood pressure diastolic abnormal 350.78 10.88 382 361460 11535 64125355
Acute kidney injury 349.88 10.88 1318 360524 447922 63688968
Death 347.60 10.88 1461 360381 481244 63655646
Duodenal ulcer perforation 332.05 10.88 652 361190 33973 64102917
Anxiety 322.95 10.88 397 361445 202252 63934638
Musculoskeletal stiffness 315.55 10.88 1449 360393 121757 64015133
Hypoglycaemia 314.72 10.88 61 361781 89831 64047059
Blood pressure fluctuation 308.53 10.88 808 361034 51063 64085827
Electrocardiogram QT prolonged 295.46 10.88 46 361796 79402 64057488
International normalised ratio increased 291.79 10.88 47 361795 79120 64057770
Ill-defined disorder 286.72 10.88 710 361132 43342 64093548
Blood pressure systolic abnormal 282.75 10.88 313 361529 9629 64127261
Hyponatraemia 282.01 10.88 250 361592 148089 63988801
Bone marrow failure 275.08 10.88 737 361105 47215 64089675
C-reactive protein abnormal 272.52 10.88 542 361300 28505 64108385
Cardio-respiratory arrest 271.36 10.88 106 361736 98287 64038603
Bradycardia 270.42 10.88 164 361678 118055 64018835
Rheumatoid nodule 270.03 10.88 344 361498 12307 64124583
Discomfort 269.42 10.88 1031 360811 79847 64057043
C-reactive protein increased 268.52 10.88 1150 360692 93759 64043131
Suicide attempt 266.59 10.88 40 361802 70967 64065923
Somnolence 264.64 10.88 460 361382 203185 63933705
Haematotoxicity 263.24 10.88 343 361499 12553 64124337
Dehydration 254.12 10.88 521 361321 216242 63920648
Diarrhoea 249.94 10.88 2723 359119 719981 63416909
Post transplant lymphoproliferative disorder 248.49 10.88 287 361555 9257 64127633
Throat irritation 245.14 10.88 557 361285 32154 64104736
Cardiac failure congestive 244.69 10.88 223 361619 130357 64006533
Intentional product misuse 233.01 10.88 59 361783 72236 64064654
Chronic lymphocytic leukaemia recurrent 227.65 10.88 94 361748 472 64136418
Herpes zoster 227.45 10.88 964 360878 78223 64058667
B-cell lymphoma recurrent 226.58 10.88 105 361737 727 64136163
Cytopenia 223.54 10.88 349 361493 15122 64121768
Cardiac arrest 222.81 10.88 324 361518 153740 63983150
COVID-19 221.56 10.88 836 361006 64304 64072586
Granuloma skin 220.71 10.88 218 361624 5856 64131034
Agranulocytosis 220.71 10.88 589 361253 37640 64099250
Diffuse large B-cell lymphoma refractory 219.43 10.88 113 361729 1011 64135879
Muscle spasms 218.60 10.88 282 361560 140741 63996149
Constipation 216.06 10.88 618 361224 228719 63908171
Seizure 215.86 10.88 378 361464 166514 63970376
Disease recurrence 215.84 10.88 518 361324 30992 64105898
Agitation 214.38 10.88 114 361728 88253 64048637
Hyperkalaemia 214.07 10.88 153 361689 100976 64035914
Basal cell carcinoma 210.21 10.88 506 361336 30332 64106558
Therapy partial responder 209.84 10.88 273 361569 9975 64126915
Depressed level of consciousness 208.18 10.88 98 361744 81338 64055552
JC virus infection 207.73 10.88 163 361679 3192 64133698
Blood parathyroid hormone decreased 206.20 10.88 230 361612 7136 64129754
Oedema peripheral 206.09 10.88 556 361286 209761 63927129
Epstein-Barr virus infection 202.12 10.88 297 361545 12191 64124699
Hallucination 201.38 10.88 78 361764 72710 64064180
Cerebrovascular accident 199.27 10.88 289 361553 137294 63999596
Myalgia 199.07 10.88 366 361476 158251 63978639
Feeling abnormal 197.10 10.88 277 361565 133325 64003565
Blood pressure systolic increased 196.62 10.88 668 361174 48785 64088105
Panniculitis 195.15 10.88 245 361597 8634 64128256
Coma 194.20 10.88 126 361716 87489 64049401
Interstitial lung disease 194.09 10.88 1070 360772 96662 64040228
Myocardial infarction 193.90 10.88 399 361443 165422 63971468
Maternal exposure during pregnancy 193.25 10.88 1054 360788 94830 64042060
Wrong technique in product usage process 192.81 10.88 62 361780 64912 64071978
Drug hypersensitivity 191.73 10.88 2109 359733 235706 63901184
Pain 190.21 10.88 4248 357594 549263 63587627
Myelosuppression 190.03 10.88 416 361426 23414 64113476
COVID-19 pneumonia 189.76 10.88 336 361506 16168 64120722
Suicidal ideation 189.64 10.88 68 361774 66474 64070416
Serum sickness 186.87 10.88 150 361692 3039 64133851
Drug tolerance decreased 186.51 10.88 213 361629 6785 64130105
Dyspnoea 185.78 10.88 2877 358965 715797 63421093
B-lymphocyte count decreased 185.14 10.88 102 361740 1059 64135831
Metabolic acidosis 185.09 10.88 83 361759 70875 64066015
Hospitalisation 183.94 10.88 96 361746 75111 64061779
Inappropriate schedule of product administration 182.10 10.88 150 361692 92136 64044754
Second primary malignancy 180.61 10.88 280 361562 12057 64124833
Sleep disorder due to general medical condition, insomnia type 180.08 10.88 432 361410 25838 64111052
Respiratory arrest 177.11 10.88 40 361802 52945 64083945
Sedation 176.55 10.88 15 361827 41447 64095443
Diffuse large B-cell lymphoma 174.35 10.88 251 361591 10110 64126780
Asthenia 174.25 10.88 1549 360293 426495 63710395
Blood creatine phosphokinase increased 173.54 10.88 56 361786 58502 64078388
Therapeutic response decreased 173.52 10.88 665 361177 51523 64085367
Muscle injury 171.90 10.88 426 361416 26011 64110879
Bone erosion 170.92 10.88 264 361578 11331 64125559
Loss of consciousness 170.08 10.88 361 361481 148004 63988886
Accidental overdose 168.90 10.88 4 361838 33553 64103337
Lymphopenia 167.42 10.88 414 361428 25243 64111647
Loss of personal independence in daily activities 167.13 10.88 827 361015 71627 64065263
Oxygen saturation decreased 165.44 10.88 1099 360743 106077 64030813
Product use issue 165.14 10.88 1433 360409 150282 63986608
Lymphoma 163.10 10.88 286 361556 13655 64123235
Neutropenic sepsis 163.08 10.88 386 361456 22886 64114004
Irritable bowel syndrome 162.16 10.88 520 361322 36849 64100041
Injection site erythema 160.78 10.88 99 361743 70701 64066189
Pancytopenia 159.32 10.88 1360 360482 141949 63994941
Hip arthroplasty 157.12 10.88 361 361481 20990 64115900
Lactic acidosis 156.80 10.88 74 361768 61336 64075554
Gastrointestinal haemorrhage 156.67 10.88 316 361526 131996 64004894
Drug withdrawal syndrome 156.46 10.88 4 361838 31287 64105603
Folliculitis 156.35 10.88 446 361396 29631 64107259
Aspergillus infection 152.87 10.88 305 361537 16074 64120816
Aggression 152.34 10.88 36 361806 46196 64090694
Inflammation 151.07 10.88 746 361096 64554 64072336
Decreased appetite 148.53 10.88 946 360896 280343 63856547
Plasma cell myeloma 147.70 10.88 38 361804 46037 64090853
Disease progression 147.34 10.88 1325 360517 140355 63996535
Tremor 147.31 10.88 389 361453 147841 63989049
Nausea 147.25 10.88 3325 358517 782475 63354415
Hypokalaemia 144.45 10.88 291 361551 121612 64015278
Intentional self-injury 144.15 10.88 4 361838 29040 64107850
Dyskinesia 143.74 10.88 24 361818 39364 64097526
Foot deformity 141.82 10.88 297 361545 16207 64120683
Insomnia 141.81 10.88 599 361243 197237 63939653
Ear pruritus 140.94 10.88 118 361724 2542 64134348
Unresponsive to stimuli 139.39 10.88 54 361788 50339 64086551
Coronary artery disease 139.32 10.88 83 361759 60350 64076540
Coeliac disease 138.77 10.88 189 361653 7223 64129667
Vision blurred 138.48 10.88 182 361660 90134 64046756
Incorrect dose administered 137.93 10.88 85 361757 60680 64076210
Confusional state 137.47 10.88 879 360963 260265 63876625
Lethargy 134.73 10.88 125 361717 72469 64064421
Mantle cell lymphoma recurrent 133.94 10.88 62 361780 428 64136462
Cytomegalovirus infection reactivation 133.20 10.88 163 361679 5593 64131297
Therapeutic product effect incomplete 132.31 10.88 1014 360828 102468 64034422
Emotional distress 131.42 10.88 22 361820 36016 64100874
Syncope 130.59 10.88 450 361392 157185 63979705
Rash 130.57 10.88 3431 358411 455118 63681772
Therapy non-responder 129.80 10.88 720 361122 65179 64071711
Demyelination 129.07 10.88 175 361667 6659 64130231
Bronchopulmonary aspergillosis 127.75 10.88 311 361531 18774 64118116
Disorientation 126.85 10.88 78 361764 55750 64081140
Abdominal pain 126.27 10.88 1132 360710 311243 63825647
Malaise 125.85 10.88 1520 360322 394727 63742163
Sopor 125.55 10.88 11 361831 29650 64107240
Product prescribing error 125.41 10.88 23 361819 35246 64101644
Febrile bone marrow aplasia 125.36 10.88 226 361616 11029 64125861
Injection site swelling 125.30 10.88 38 361804 41315 64095575
Skin necrosis 124.46 10.88 259 361583 14070 64122820
Acquired gene mutation 124.06 10.88 97 361745 1889 64135001
Diabetic ketoacidosis 123.84 10.88 12 361830 29833 64107057
Drug effective for unapproved indication 121.77 10.88 126 361716 3582 64133308
Swelling face 120.68 10.88 93 361749 59073 64077817
Acute myocardial infarction 119.13 10.88 129 361713 69589 64067301
Pulmonary fibrosis 119.11 10.88 404 361438 29474 64107416
Hypotension 118.10 10.88 1469 360373 379505 63757385
Injection site pruritus 117.84 10.88 33 361809 37793 64099097
Chest pain 117.78 10.88 807 361035 235173 63901717
Lower respiratory tract infection 117.01 10.88 920 360922 93694 64043196
Orthostatic hypotension 116.76 10.88 58 361784 46680 64090210
Neutrophil count decreased 116.34 10.88 787 361055 76409 64060481
Haematochezia 115.43 10.88 121 361721 66252 64070638
Immunodeficiency 114.67 10.88 269 361573 15855 64121035
Therapy cessation 113.78 10.88 22 361820 32467 64104423
Dysgeusia 113.64 10.88 61 361781 46986 64089904
Blood pressure diastolic decreased 113.30 10.88 328 361514 21973 64114917
Chills 112.63 10.88 1222 360620 136042 64000848
Apparent death 112.32 10.88 104 361738 2572 64134318
Knee arthroplasty 111.99 10.88 370 361472 26629 64110261
Angioedema 111.74 10.88 109 361733 61712 64075178
Cytokine release syndrome 111.32 10.88 312 361530 20517 64116373
Haematemesis 110.54 10.88 63 361779 46936 64089954
Leukopenia 109.96 10.88 956 360886 100286 64036604
Dislocation of vertebra 109.59 10.88 110 361732 3014 64133876
Product quality issue 109.09 10.88 18 361824 29781 64107109
Ulcer 109.06 10.88 330 361512 22660 64114230
Memory impairment 108.07 10.88 197 361645 85485 64051405
Multiple sclerosis relapse 107.45 10.88 48 361794 41087 64095803
Pneumocystis jirovecii infection 107.40 10.88 96 361746 2265 64134625
Hepatitis E 106.95 10.88 97 361745 2334 64134556
Pneumonia cytomegaloviral 105.51 10.88 126 361716 4213 64132677
Breast cancer stage III 105.06 10.88 104 361738 2801 64134089
Blood pressure increased 104.64 10.88 1451 360391 171101 63965789
Restlessness 104.59 10.88 46 361796 39739 64097151
SLE arthritis 104.40 10.88 54 361788 488 64136402
Smooth muscle cell neoplasm 103.30 10.88 63 361779 803 64136087
Musculoskeletal deformity 103.03 10.88 57 361785 597 64136293
Labelled drug-drug interaction medication error 102.74 10.88 5 361837 22057 64114833
Impaired healing 102.44 10.88 635 361207 59838 64077052
Elbow deformity 101.32 10.88 72 361770 1205 64135685
Hyperglycaemia 100.67 10.88 116 361726 60852 64076038
Pyrexia 100.62 10.88 3957 357885 554687 63582203
Blood glucose increased 99.99 10.88 254 361588 97819 64039071
Drug ineffective for unapproved indication 99.63 10.88 392 361450 30741 64106149
Sinusitis 99.23 10.88 1253 360589 144675 63992215
Abdominal pain upper 98.91 10.88 576 361266 174454 63962436
Abnormal behaviour 98.13 10.88 33 361809 33589 64103301
Hallucination, visual 97.16 10.88 19 361823 27815 64109075
Arthritis 96.05 10.88 801 361041 83013 64053877
Irritability 95.79 10.88 43 361799 36703 64100187
Paraesthesia 95.30 10.88 409 361433 134113 64002777
Blood alkaline phosphatase increased 95.19 10.88 105 361737 56174 64080716
Nasopharyngitis 94.29 10.88 1585 360257 194488 63942402
Device issue 94.25 10.88 9 361833 22639 64114251
No adverse event 94.15 10.88 363 361479 28198 64108692
Epistaxis 94.10 10.88 262 361580 97869 64039021
Palmar-plantar erythrodysaesthesia syndrome 93.85 10.88 23 361819 28796 64108094
Disability 93.11 10.88 209 361633 11963 64124927
Balance disorder 93.00 10.88 208 361634 83718 64053172
Acute myeloid leukaemia 92.96 10.88 352 361490 27111 64109779
Autoimmune haemolytic anaemia 91.79 10.88 152 361690 6924 64129966
Osteonecrosis of jaw 91.37 10.88 55 361787 39770 64097120
Nightmare 91.03 10.88 7 361835 20986 64115904
Injection site haemorrhage 90.37 10.88 14 361828 24264 64112626
Posterior reversible encephalopathy syndrome 89.47 10.88 308 361534 22638 64114252
Blood urea increased 89.28 10.88 70 361772 44083 64092807
Extrapyramidal disorder 89.26 10.88 5 361837 19547 64117343
Lymphoma transformation 89.25 10.88 37 361805 188 64136702
Rheumatic fever 89.06 10.88 175 361667 9119 64127771
Swollen joint count increased 88.98 10.88 157 361685 7532 64129358
Glomerulonephritis 88.16 10.88 95 361747 2833 64134057
Contrast media allergy 87.53 10.88 82 361760 2059 64134831
Product substitution issue 86.69 10.88 3 361839 17858 64119032
Withdrawal syndrome 86.42 10.88 14 361828 23478 64113412
Blood cholesterol increased 86.23 10.88 528 361314 49538 64087352
Gamma-glutamyltransferase increased 85.98 10.88 87 361755 48423 64088467
Depression 85.49 10.88 639 361203 182652 63954238
Gastrointestinal disorder 84.20 10.88 821 361021 88888 64048002
Haemophagocytic lymphohistiocytosis 83.75 10.88 253 361589 17356 64119534
Gastric disorder 83.44 10.88 355 361487 28842 64108048
Abdominal distension 82.22 10.88 270 361572 95724 64041166
Red blood cell sedimentation rate abnormal 82.04 10.88 239 361603 16067 64120823
Blister 81.97 10.88 753 361089 80214 64056676
Mucosal inflammation 81.50 10.88 616 361226 61968 64074922
Venoocclusive liver disease 81.17 10.88 176 361666 9839 64127051
Seronegative arthritis 80.84 10.88 88 361754 2655 64134235
Dry skin 80.58 10.88 101 361741 51060 64085830
Pulmonary oedema 80.01 10.88 204 361638 78470 64058420
Surgical failure 79.94 10.88 52 361790 747 64136143
Heart rate decreased 79.75 10.88 556 361286 54511 64082379
Obliterative bronchiolitis 79.42 10.88 86 361756 2579 64134311
Tachycardia 79.38 10.88 502 361340 149077 63987813
Melaena 78.95 10.88 111 361731 53437 64083453
Pseudomonas infection 78.62 10.88 250 361592 17633 64119257
Septic shock 78.46 10.88 921 360921 104516 64032374
Lymphadenopathy 78.29 10.88 489 361353 46197 64090693
Skin ulcer 77.79 10.88 467 361375 43507 64093383
Mental status changes 77.68 10.88 140 361702 61022 64075868
Pancreatitis 77.00 10.88 135 361707 59472 64077418
Fine motor skill dysfunction 76.39 10.88 112 361730 4587 64132303
Poisoning 76.23 10.88 15 361827 21864 64115026
Flatulence 75.39 10.88 54 361788 35612 64101278
Atlantoaxial instability 75.38 10.88 36 361806 269 64136621
Thrombocytopenia 75.34 10.88 1714 360128 222087 63914803
Hypophagia 74.83 10.88 67 361775 39520 64097370
Rectal haemorrhage 74.54 10.88 146 361696 61671 64075219
Back pain 74.30 10.88 973 360869 249198 63887692
Stomatitis 74.01 10.88 940 360902 108665 64028225
Wrist deformity 73.70 10.88 69 361773 1731 64135159
Dysarthria 73.65 10.88 138 361704 59268 64077622
Urinary tract infection 73.54 10.88 888 360954 230708 63906182
Generalised tonic-clonic seizure 73.51 10.88 69 361773 39788 64097102
Hypomagnesaemia 73.40 10.88 61 361781 37315 64099575
Accidental exposure to product 73.32 10.88 28 361814 26336 64110554
Gastrooesophageal reflux disease 73.19 10.88 231 361611 82912 64053978
Swollen tongue 72.48 10.88 54 361788 34900 64101990
Pancreatitis acute 72.43 10.88 80 361762 42775 64094115
Dystonia 72.25 10.88 10 361832 18855 64118035
Meningoencephalitis viral 71.85 10.88 38 361804 361 64136529
Mineral metabolism disorder 71.49 10.88 35 361807 278 64136612
Ventricular tachycardia 70.97 10.88 53 361789 34212 64102678
Vasculitis 70.65 10.88 243 361599 17852 64119038
Lip swelling 70.52 10.88 46 361796 31861 64105029
Head injury 70.37 10.88 49 361793 32793 64104097
Disturbance in attention 70.16 10.88 76 361766 40998 64095892
Joint stiffness 70.05 10.88 347 361495 30057 64106833
Red blood cell sedimentation rate 69.98 10.88 95 361747 3619 64133271
Blood potassium decreased 69.85 10.88 74 361768 40325 64096565
Cytomegalovirus chorioretinitis 69.83 10.88 110 361732 4802 64132088
Sepsis 69.29 10.88 1737 360105 228604 63908286
Delirium 69.14 10.88 181 361661 69013 64067877
Depressed mood 68.83 10.88 77 361765 40935 64095955
Blood glucose decreased 68.70 10.88 22 361820 23101 64113789
Urinary retention 68.62 10.88 106 361736 49095 64087795
Blood bilirubin increased 68.48 10.88 137 361705 57416 64079474
Peripheral swelling 68.28 10.88 1595 360247 207558 63929332
Temperature regulation disorder 67.92 10.88 100 361742 4111 64132779
Joint range of motion decreased 67.19 10.88 250 361592 19093 64117797
Sciatica 67.16 10.88 258 361584 20006 64116884
Injection site bruising 67.04 10.88 63 361779 36310 64100580
Speech disorder 66.95 10.88 105 361737 48336 64088554
Hyperlipidaemia 66.27 10.88 23 361819 22953 64113937
Hypocalcaemia 66.20 10.88 82 361760 41671 64095219
Underdose 66.12 10.88 31 361811 25798 64111092
Spinal instability 66.04 10.88 35 361807 334 64136556
Hypercalcaemia 65.72 10.88 349 361493 31067 64105823
Chronic kidney disease 65.43 10.88 142 361700 57777 64079113
Adenovirus infection 65.20 10.88 133 361709 7122 64129768
Infusion site reaction 65.13 10.88 69 361773 2017 64134873
Gait disturbance 65.10 10.88 634 361208 171521 63965369
Respiratory depression 65.03 10.88 25 361817 23418 64113472
Surgery 64.67 10.88 39 361803 28174 64108716
Injection site mass 64.19 10.88 10 361832 17260 64119630
Device malfunction 63.77 10.88 11 361831 17622 64119268
Injection site rash 63.58 10.88 7 361835 15735 64121155
Blood calcium decreased 63.39 10.88 32 361810 25522 64111368
Pulmonary hypertension 63.02 10.88 90 361752 43049 64093841
Myoclonus 62.99 10.88 31 361811 25087 64111803
Frequent bowel movements 62.84 10.88 13 361829 18292 64118598
Product administration error 62.26 10.88 39 361803 27604 64109286
Humoral immune defect 62.25 10.88 24 361818 97 64136793
West Nile viral infection 62.12 10.88 47 361795 870 64136020
Product storage error 62.08 10.88 3 361839 13315 64123575
Blood sodium decreased 61.84 10.88 45 361797 29437 64107453
Cerebral toxoplasmosis 61.68 10.88 63 361779 1763 64135127
Remission not achieved 61.56 10.88 33 361809 323 64136567
Drug-induced liver injury 61.45 10.88 108 361734 47535 64089355
Therapy interrupted 61.45 10.88 18 361824 20018 64116872
Psychotic disorder 61.29 10.88 62 361780 34516 64102374
Secondary immunodeficiency 61.20 10.88 76 361766 2648 64134242
Bone swelling 60.41 10.88 52 361790 1165 64135725
Circulatory collapse 60.34 10.88 60 361782 33672 64103218
Blood iron abnormal 60.32 10.88 51 361791 1114 64135776
Osteoarthritis 60.09 10.88 581 361261 62755 64074135
Bronchitis chronic 60.03 10.88 91 361751 3841 64133049
Faeces discoloured 59.77 10.88 35 361807 25694 64111196
Cardiomegaly 59.74 10.88 29 361813 23655 64113235
Delusion 59.40 10.88 14 361828 18000 64118890
Unevaluable event 59.37 10.88 121 361721 50368 64086522
Creatinine renal clearance decreased 59.30 10.88 6 361836 14415 64122475
Skin exfoliation 58.57 10.88 101 361741 44784 64092106
Torsade de pointes 58.24 10.88 13 361829 17350 64119540
Hallucination, auditory 58.21 10.88 12 361830 16927 64119963
Asthma 57.78 10.88 306 361536 94919 64041971
Intestinal sepsis 57.51 10.88 39 361803 603 64136287
Palpitations 57.33 10.88 347 361495 104141 64032749
Drug reaction with eosinophilia and systemic symptoms 57.14 10.88 138 361704 54079 64082811
Cerebral haemorrhage 57.10 10.88 126 361716 50964 64085926
Musculoskeletal disorder 56.92 10.88 225 361617 17681 64119209
Babesiosis 56.45 10.88 29 361813 258 64136632
Blood pressure diastolic increased 56.42 10.88 160 361682 10592 64126298
Pneumonia aspiration 56.25 10.88 159 361683 59112 64077778
Vertigo 56.23 10.88 158 361684 58853 64078037
Miosis 55.93 10.88 5 361837 13261 64123629
Abortion spontaneous 55.91 10.88 36 361806 25107 64111783
Hypervolaemia 55.80 10.88 80 361762 38205 64098685
Blood immunoglobulin G decreased 55.75 10.88 72 361770 2611 64134279
Bacteraemia 55.64 10.88 298 361544 26613 64110277
Angina unstable 55.17 10.88 10 361832 15457 64121433
Fear 55.14 10.88 22 361820 20149 64116741
Chromaturia 55.07 10.88 29 361813 22582 64114308
Muscle rigidity 54.88 10.88 15 361827 17458 64119432
Metastases to bone 54.71 10.88 23 361819 20412 64116478
Obstructive airways disorder 54.63 10.88 31 361811 23154 64113736
Sarcoidosis 54.44 10.88 112 361730 6034 64130856
Prothrombin time prolonged 54.40 10.88 11 361831 15730 64121160
Pain in extremity 54.01 10.88 1291 360551 301794 63835096
Jaundice 53.92 10.88 120 361722 48392 64088498
Spinal column injury 53.86 10.88 59 361783 1793 64135097
Chronic lymphocytic leukaemia 53.72 10.88 91 361751 4224 64132666
5q minus syndrome 53.58 10.88 28 361814 259 64136631
Electric shock 53.54 10.88 47 361795 1082 64135808
Cardiac disorder 53.51 10.88 149 361693 55667 64081223
Encephalitis enteroviral 53.49 10.88 23 361819 130 64136760
Tenosynovitis 53.46 10.88 167 361675 11666 64125224
Drug level increased 53.34 10.88 68 361774 34128 64102762
Right ventricular failure 53.09 10.88 27 361815 21444 64115446
BK virus infection 53.08 10.88 124 361718 7288 64129602
Microsporidia infection 52.66 10.88 40 361802 745 64136145
Cytomegalovirus viraemia 51.89 10.88 156 361686 10672 64126218
Injection site warmth 51.88 10.88 7 361835 13455 64123435
Transient ischaemic attack 51.85 10.88 106 361736 44076 64092814
Physical disability 51.73 10.88 64 361778 2221 64134669
Blood loss anaemia 51.73 10.88 8 361834 13884 64123006
Herpes simplex 51.64 10.88 153 361689 10383 64126507
Temperature intolerance 51.54 10.88 131 361711 8124 64128766
Dyspnoea exertional 51.08 10.88 226 361616 73504 64063386
Altered state of consciousness 50.64 10.88 84 361758 37818 64099072
Anaemia 50.39 10.88 1680 360162 377000 63759890
Device dislocation 50.35 10.88 28 361814 21150 64115740
Nervousness 50.14 10.88 55 361787 29501 64107389
Hypersomnia 49.95 10.88 24 361818 19693 64117197
Laryngeal disorder 49.84 10.88 41 361801 861 64136029
Nodule 49.57 10.88 216 361626 17731 64119159
Myocardial ischaemia 49.41 10.88 35 361807 23216 64113674
Urinary incontinence 49.35 10.88 79 361763 36072 64100818
Headache 49.27 10.88 2448 359394 527019 63609871
Blood potassium increased 49.07 10.88 44 361798 25936 64110954
JC polyomavirus test positive 49.05 10.88 47 361795 1215 64135675
Nasal congestion 48.89 10.88 171 361671 59487 64077403
Onychomycosis 48.78 10.88 97 361745 5099 64131791
Blood immunoglobulin M decreased 48.75 10.88 42 361800 942 64135948
Coombs positive haemolytic anaemia 48.70 10.88 40 361802 838 64136052
Psoriasis 48.34 10.88 222 361620 71481 64065409
Candida infection 48.32 10.88 322 361520 31097 64105793
Terminal state 47.92 10.88 88 361754 4356 64132534
Injection site urticaria 47.72 10.88 4 361838 11177 64125713
Staphylococcal bacteraemia 47.58 10.88 147 361695 10208 64126682
Transfusion 46.99 10.88 21 361821 17973 64118917
Haemoptysis 46.97 10.88 131 361711 48917 64087973
Arthrodesis 46.97 10.88 58 361784 2009 64134881
Haematoma 46.96 10.88 120 361722 46130 64090760
Central nervous system lymphoma 46.74 10.88 56 361786 1879 64135011
Sinus bradycardia 46.66 10.88 36 361806 22857 64114033
Cholelithiasis 46.25 10.88 118 361724 45388 64091502
Coagulopathy 46.22 10.88 67 361775 31853 64105037
Lymphadenitis 46.03 10.88 79 361763 3706 64133184
Mania 45.79 10.88 17 361825 16269 64120621
Parkinsonism 45.78 10.88 12 361830 14361 64122529
Incorrect route of product administration 45.77 10.88 38 361804 23260 64113630
B-cell lymphoma refractory 45.60 10.88 19 361823 98 64136792
Inappropriate antidiuretic hormone secretion 45.49 10.88 35 361807 22254 64114636
Migraine 45.33 10.88 189 361653 62488 64074402
Cystitis haemorrhagic 45.32 10.88 122 361720 7834 64129056
Upper gastrointestinal haemorrhage 45.27 10.88 80 361762 35140 64101750
Mantle cell lymphoma 45.08 10.88 43 361799 1105 64135785
Gene mutation 45.04 10.88 57 361785 2025 64134865
Chronic obstructive pulmonary disease 44.97 10.88 225 361617 70823 64066067
Visual impairment 44.96 10.88 238 361604 73839 64063051
Metastases to liver 44.67 10.88 41 361801 23900 64112990
Squamous cell carcinoma 44.67 10.88 175 361667 13694 64123196
Acidosis 44.57 10.88 22 361820 17773 64119117
Epstein-Barr virus infection reactivation 44.52 10.88 43 361799 1123 64135767
Renal failure 44.39 10.88 734 361108 180954 63955936
Drug level decreased 44.29 10.88 6 361836 11497 64125393
Chronic lymphocytic leukaemia refractory 44.24 10.88 19 361823 107 64136783
Platelet count abnormal 43.81 10.88 81 361761 4031 64132859
Ankle operation 43.71 10.88 40 361802 974 64135916
Immunoglobulins decreased 43.67 10.88 45 361797 1273 64135617
Mantle cell lymphoma refractory 43.49 10.88 18 361824 91 64136799
Gastrosplenic fistula 43.47 10.88 17 361825 72 64136818
Anger 43.31 10.88 17 361825 15724 64121166
Medication error 43.14 10.88 140 361702 49826 64087064
Mydriasis 43.02 10.88 16 361826 15296 64121594
Blood immunoglobulin A decreased 42.99 10.88 30 361812 487 64136403
Thyroid neoplasm 42.72 10.88 63 361779 2594 64134296
Iron deficiency anaemia 42.64 10.88 36 361806 21853 64115037
Cardiogenic shock 42.28 10.88 73 361769 32354 64104536
End stage renal disease 42.06 10.88 142 361700 10333 64126557
Grip strength decreased 41.95 10.88 153 361689 11571 64125319
Hyperthyroidism 41.85 10.88 25 361817 18154 64118736
Electrocardiogram abnormal 41.54 10.88 12 361830 13469 64123421
Ageusia 41.29 10.88 13 361829 13800 64123090
Pollakiuria 41.09 10.88 71 361771 31459 64105431
Abdominal pain lower 40.90 10.88 53 361789 26416 64110474
Caesarean section 40.84 10.88 7 361835 11267 64125623
Cataract 40.46 10.88 453 361389 50809 64086081
Lymphocytosis 40.36 10.88 73 361769 3571 64133319
Electrocardiogram QRS complex prolonged 40.31 10.88 3 361839 9241 64127649
Treatment noncompliance 40.26 10.88 118 361724 43364 64093526
Haemodialysis 39.99 10.88 23 361819 17054 64119836
Wheezing 39.92 10.88 276 361566 80303 64056587
Tumour flare 39.82 10.88 34 361808 753 64136137
Full blood count abnormal 39.71 10.88 66 361776 29691 64107199
Bunion operation 39.60 10.88 34 361808 759 64136131
Type 2 diabetes mellitus 39.42 10.88 326 361516 33694 64103196
Road traffic accident 39.37 10.88 70 361772 30675 64106215
Post procedural complication 39.33 10.88 37 361805 21316 64115574
Dialysis 39.33 10.88 23 361819 16897 64119993
Cerebral aspergillosis 39.27 10.88 48 361794 1645 64135245
Joint destruction 39.21 10.88 72 361770 3564 64133326
Systemic lupus erythematosus rash 39.04 10.88 44 361798 1381 64135509
Cytomegalovirus colitis 38.90 10.88 75 361767 3853 64133037
Presyncope 38.83 10.88 87 361755 35002 64101888
Salivary hypersecretion 38.80 10.88 10 361832 12103 64124787
Mental disorder 38.79 10.88 55 361787 26390 64110500
Injection site induration 38.67 10.88 3 361839 8929 64127961
Muscular weakness 38.59 10.88 493 361349 126845 64010045
Intestinal obstruction 38.52 10.88 92 361750 36194 64100696
Mean platelet volume decreased 38.41 10.88 48 361794 1683 64135207
Enterovirus infection 38.24 10.88 44 361798 1413 64135477
Hip fracture 38.15 10.88 58 361784 27041 64109849
Device difficult to use 37.98 10.88 5 361837 9793 64127097
Sinus tachycardia 37.96 10.88 77 361765 32111 64104779
Hypokinesia 37.95 10.88 23 361819 16573 64120317
Incorrect product administration duration 37.78 10.88 5 361837 9753 64127137
Influenza like illness 37.58 10.88 198 361644 61504 64075386
Food allergy 37.52 10.88 113 361729 7738 64129152
Visual acuity reduced 37.34 10.88 59 361783 27082 64109808
Herpes simplex encephalitis 37.24 10.88 30 361812 611 64136279
Hepatic function abnormal 37.18 10.88 210 361632 64103 64072787
Platelet count decreased 37.16 10.88 1217 360625 166494 63970396
Anaphylactic shock 37.11 10.88 71 361771 30257 64106633
Hypothermia 37.05 10.88 34 361808 19822 64117068
Eye pain 37.00 10.88 76 361766 31549 64105341
Hypoaesthesia 36.99 10.88 553 361289 138555 63998335
Middle insomnia 36.95 10.88 13 361829 12864 64124026
Therapeutic response unexpected 36.91 10.88 25 361817 16976 64119914
Meningitis cryptococcal 36.85 10.88 63 361779 2946 64133944
Adverse event 36.84 10.88 361 361481 39128 64097762
Blood creatinine increased 36.72 10.88 538 361304 135244 64001646
Pulmonary thrombosis 36.58 10.88 136 361706 10382 64126508
Arteriosclerosis coronary artery 36.25 10.88 21 361821 15508 64121382
Illness 35.93 10.88 42 361800 21896 64114994
Episcleritis 35.87 10.88 33 361809 809 64136081
Varicella zoster virus infection 35.80 10.88 72 361770 3816 64133074
Neck deformity 35.66 10.88 46 361796 1666 64135224
Panic attack 35.53 10.88 39 361803 20914 64115976
Immune effector cell-associated neurotoxicity syndrome 35.36 10.88 57 361785 2538 64134352
Dysstasia 35.34 10.88 47 361795 23168 64113722
Anaphylactic reaction 35.15 10.88 561 361281 68103 64068787
Dementia 34.83 10.88 39 361803 20727 64116163
Fluid retention 34.80 10.88 194 361648 59412 64077478
Impaired work ability 34.56 10.88 173 361669 15046 64121844
B-cell lymphoma 34.49 10.88 87 361755 5370 64131520
Adenovirus reactivation 34.26 10.88 20 361822 234 64136656
Leukoerythroblastosis 34.26 10.88 20 361822 234 64136656
Polyomavirus-associated nephropathy 34.16 10.88 81 361761 4807 64132083
Cellulitis 34.09 10.88 348 361494 93309 64043581
Haematocrit decreased 34.06 10.88 174 361668 54481 64082409
X-ray abnormal 34.05 10.88 42 361800 1453 64135437
Cognitive disorder 33.98 10.88 176 361666 54911 64081979
Enterococcal infection 33.91 10.88 161 361681 13705 64123185
Acute hepatitis B 33.75 10.88 24 361818 402 64136488
Ventricular fibrillation 33.65 10.88 51 361791 23809 64113081
Cytology abnormal 33.41 10.88 22 361820 323 64136567
Hyperpyrexia 33.20 10.88 82 361760 4995 64131895
Pulmonary arterial hypertension 33.17 10.88 57 361785 25310 64111580
Chronic lymphocytic leukaemia transformation 33.16 10.88 19 361823 214 64136676
Skin discolouration 33.14 10.88 95 361747 35160 64101730
Shock 33.11 10.88 107 361735 38133 64098757
Tricuspid valve incompetence 33.07 10.88 28 361814 16975 64119915
Immunodeficiency common variable 33.06 10.88 20 361822 251 64136639
Soft tissue disorder 32.99 10.88 63 361779 3213 64133677
Complication associated with device 32.97 10.88 22 361820 15058 64121832
Condition aggravated 32.95 10.88 2470 359372 369956 63766934
Mitral valve incompetence 32.83 10.88 58 361784 25480 64111410
Drug resistance 32.79 10.88 321 361521 34781 64102109
Electrolyte imbalance 32.75 10.88 57 361785 25186 64111704
Psoriatic arthropathy 32.59 10.88 379 361463 42902 64093988
Coma scale abnormal 32.59 10.88 3 361839 7771 64129119
Cytomegalovirus test positive 32.50 10.88 82 361760 5062 64131828
Stevens-Johnson syndrome 32.40 10.88 92 361750 34157 64102733
Eating disorder 32.29 10.88 28 361814 16777 64120113
Hepatitis B surface antigen positive 32.28 10.88 17 361825 160 64136730
Mesenteritis 32.26 10.88 18 361824 192 64136698
Dysuria 32.19 10.88 124 361718 41933 64094957
Burning sensation 32.16 10.88 156 361686 49508 64087382
Haemolysis 32.14 10.88 135 361707 10904 64125986
Gastric stenosis 32.11 10.88 15 361827 106 64136784
Refractory anaemia with an excess of blasts 31.92 10.88 31 361811 815 64136075
Drug dependence 31.87 10.88 89 361753 33223 64103667
Psychomotor hyperactivity 31.71 10.88 21 361821 14430 64122460
Coxsackie viral infection 31.62 10.88 12 361830 46 64136844
SARS-CoV-2 antibody test negative 31.62 10.88 12 361830 46 64136844
Ventricular extrasystoles 31.56 10.88 31 361811 17498 64119392
Toxic epidermal necrolysis 31.49 10.88 105 361737 37061 64099829
Acute generalised exanthematous pustulosis 31.43 10.88 20 361822 14038 64122852
Cerebral infarction 31.42 10.88 121 361721 40923 64095967
Pneumonia viral 31.37 10.88 106 361736 7716 64129174
Poor quality sleep 31.34 10.88 36 361806 18915 64117975
Sudden death 31.30 10.88 40 361802 20056 64116834
Pseudomonal bacteraemia 31.14 10.88 50 361792 2219 64134671
Viral haemorrhagic cystitis 31.08 10.88 42 361800 1593 64135297
Erectile dysfunction 31.04 10.88 16 361826 12611 64124279
Traumatic lung injury 31.02 10.88 50 361792 2226 64134664
Needle issue 30.98 10.88 7 361835 9265 64127625
Prostatic specific antigen increased 30.53 10.88 6 361836 8754 64128136
Deformity 30.44 10.88 91 361751 6206 64130684
Thirst 30.41 10.88 21 361821 14116 64122774
Glycosylated haemoglobin increased 30.41 10.88 27 361815 15992 64120898
Eczema 30.25 10.88 77 361765 29643 64107247
Human herpesvirus 6 infection 30.25 10.88 75 361767 4579 64132311
Monocyte count increased 30.24 10.88 107 361735 7972 64128918
Epstein-Barr virus associated lymphoproliferative disorder 30.21 10.88 59 361783 3060 64133830
Respiratory acidosis 29.95 10.88 9 361833 9846 64127044
Subdural haematoma 29.88 10.88 71 361771 27983 64108907
Oedema 29.71 10.88 351 361491 91584 64045306
Dermatitis contact 29.66 10.88 7 361835 8993 64127897
Haemorrhage 29.64 10.88 293 361549 79058 64057832
Mobility decreased 29.64 10.88 660 361182 85180 64051710
Choking 29.62 10.88 11 361831 10527 64126363
Infection reactivation 29.61 10.88 46 361796 1984 64134906
Encephalitis viral 29.37 10.88 50 361792 2330 64134560
Amnesia 29.33 10.88 155 361687 48114 64088776
Full blood count decreased 29.29 10.88 51 361791 22531 64114359
Catatonia 29.28 10.88 4 361838 7616 64129274
Schizophrenia 29.21 10.88 13 361829 11155 64125735
White blood cell count decreased 29.18 10.88 1122 360720 156715 63980175
Activated partial thromboplastin time prolonged 29.04 10.88 18 361824 12813 64124077
Steroid diabetes 29.01 10.88 53 361789 2613 64134277
Cardiomyopathy 28.85 10.88 242 361600 25114 64111776
Pneumonia adenoviral 28.81 10.88 16 361826 169 64136721
Autoimmune lymphoproliferative syndrome 28.81 10.88 16 361826 169 64136721
Enterococcal bacteraemia 28.79 10.88 51 361791 2454 64134436
Hypoxia 28.70 10.88 336 361506 87813 64049077
Red cell distribution width decreased 28.67 10.88 33 361809 1060 64135830
Vascular access complication 28.55 10.88 33 361809 1065 64135825
Muscle spasticity 28.29 10.88 31 361811 16638 64120252
Eye swelling 28.29 10.88 51 361791 22230 64114660
Adjustment disorder with depressed mood 28.21 10.88 50 361792 2407 64134483
Paranoia 28.21 10.88 30 361812 16322 64120568
Myeloid leukaemia 28.21 10.88 25 361817 583 64136307
Liver function test abnormal 28.18 10.88 206 361636 59195 64077695
Intervertebral discitis 28.14 10.88 65 361777 3792 64133098
Campylobacter gastroenteritis 28.11 10.88 33 361809 1083 64135807
Pelvic pain 28.07 10.88 13 361829 10897 64125993
Intestinal perforation 27.96 10.88 164 361678 15149 64121741
Crystal nephropathy 27.95 10.88 35 361807 1230 64135660
Oesophagitis 27.92 10.88 49 361793 21581 64115309
Central nervous system enteroviral infection 27.88 10.88 12 361830 68 64136822
Arthritis bacterial 27.79 10.88 102 361740 7737 64129153
Ureaplasma infection 27.77 10.88 27 361815 711 64136179
Dizziness postural 27.72 10.88 10 361832 9742 64127148
Gastritis bacterial 27.68 10.88 19 361823 300 64136590
Drug tolerance 27.60 10.88 86 361756 5999 64130891
Precancerous cells present 27.58 10.88 31 361811 970 64135920
Intervertebral disc space narrowing 27.40 10.88 36 361806 1328 64135562
Infusion site pain 27.36 10.88 12 361830 10385 64126505
Heparin-induced thrombocytopenia 27.16 10.88 7 361835 8472 64128418
Finger deformity 27.04 10.88 77 361765 5109 64131781
Dermatitis acneiform 26.98 10.88 7 361835 8436 64128454
Eructation 26.86 10.88 9 361833 9182 64127708
Ischaemic stroke 26.73 10.88 79 361763 28956 64107934
Lung disorder 26.72 10.88 484 361358 60216 64076674
Ocular hyperaemia 26.59 10.88 54 361788 22510 64114380
Antineutrophil cytoplasmic antibody increased 26.58 10.88 13 361829 103 64136787
Urine output decreased 26.55 10.88 32 361810 16460 64120430
Rhinorrhoea 26.55 10.88 212 361630 59757 64077133
Apathy 26.49 10.88 15 361827 11217 64125673
Lipase increased 26.47 10.88 25 361817 14377 64122513
Thinking abnormal 26.45 10.88 16 361826 11540 64125350
Arteriosclerosis 26.43 10.88 30 361812 15847 64121043
Post-acute COVID-19 syndrome 26.36 10.88 11 361831 57 64136833
Epilepsy 26.22 10.88 98 361744 33433 64103457
Hepatitis C RNA increased 25.99 10.88 20 361822 380 64136510
Sleep disorder due to a general medical condition 25.99 10.88 7 361835 8227 64128663
Diverticulitis 25.96 10.88 331 361511 38287 64098603
Chondropathy 25.95 10.88 47 361795 2302 64134588
Gastritis 25.82 10.88 137 361705 42481 64094409
Encephalitis cytomegalovirus 25.79 10.88 30 361812 975 64135915
Hepatic amoebiasis 25.55 10.88 12 361830 86 64136804
Aspartate aminotransferase increased 25.42 10.88 496 361346 119292 64017598
Hyperhidrosis 25.39 10.88 521 361321 124399 64012491
Haemorrhagic stroke 25.38 10.88 12 361830 9939 64126951
Immune thrombocytopenia 25.37 10.88 158 361684 14908 64121982
B-cell aplasia 25.36 10.88 14 361828 146 64136744
Cryptococcosis 25.34 10.88 51 361791 2704 64134186
Cyanosis 25.28 10.88 54 361788 22101 64114789
Femur fracture 25.26 10.88 102 361740 34033 64102857
Cystitis viral 25.25 10.88 24 361818 614 64136276
Electrocardiogram ST segment elevation 25.24 10.88 5 361837 7254 64129636
Herpes simplex reactivation 25.23 10.88 17 361825 260 64136630
Oral pruritus 25.08 10.88 40 361802 1765 64135125
Blood lactate dehydrogenase increased 25.06 10.88 290 361552 32788 64104102
Blood triglycerides increased 25.03 10.88 42 361800 18824 64118066
Bipolar disorder 24.93 10.88 4 361838 6757 64130133
Onychomadesis 24.89 10.88 52 361790 2832 64134058
Cerebral haematoma 24.87 10.88 5 361837 7180 64129710
Renal injury 24.77 10.88 30 361812 15399 64121491
Periostitis 24.75 10.88 22 361820 515 64136375
Bacterial sepsis 24.75 10.88 95 361747 7362 64129528
CD4 lymphocytes decreased 24.74 10.88 47 361795 2388 64134502
Strongyloidiasis 24.70 10.88 54 361788 3036 64133854
Mood altered 24.69 10.88 32 361810 15947 64120943
Weight increased 24.57 10.88 1447 360395 211901 63924989
T-lymphocyte count decreased 24.56 10.88 21 361821 466 64136424
Alanine aminotransferase increased 24.50 10.88 593 361249 138438 63998452
Injection site hypersensitivity 24.42 10.88 38 361804 1641 64135249
Atrioventricular block first degree 24.37 10.88 15 361827 10719 64126171
Cartilage atrophy 24.34 10.88 14 361828 159 64136731
Erythropoiesis abnormal 24.31 10.88 20 361822 420 64136470
International normalised ratio decreased 24.29 10.88 6 361836 7472 64129418
Bundle branch block left 24.24 10.88 13 361829 10021 64126869
Retching 24.14 10.88 30 361812 15226 64121664
Euphoric mood 24.08 10.88 4 361838 6587 64130303
Joint arthroplasty 24.05 10.88 42 361800 1998 64134892
Affective disorder 24.03 10.88 4 361838 6576 64130314
Paraneoplastic pemphigus 24.02 10.88 12 361830 100 64136790
Procedural pain 24.02 10.88 31 361811 15477 64121413
Cholecystitis chronic 24.00 10.88 11 361831 9276 64127614
Tongue disorder 23.78 10.88 132 361710 11948 64124942
Sweat gland tumour 23.76 10.88 21 361821 488 64136402
Tubulointerstitial nephritis 23.74 10.88 91 361751 30818 64106072
Concomitant disease aggravated 23.71 10.88 18 361824 11524 64125366
Transplant rejection 23.62 10.88 173 361669 17228 64119662
Fear of injection 23.61 10.88 80 361762 5832 64131058
Subarachnoid haemorrhage 23.59 10.88 42 361800 18396 64118494
Lung infiltration 23.57 10.88 199 361643 20690 64116200
Impaired quality of life 23.48 10.88 4 361838 6467 64130423
Rhinitis allergic 23.45 10.88 8 361834 8070 64128820
Left ventricular hypertrophy 23.43 10.88 12 361830 9494 64127396
Neuroborreliosis 23.43 10.88 12 361830 106 64136784
Atrioventricular block second degree 23.40 10.88 4 361838 6450 64130440
Expired product administered 23.34 10.88 3 361839 5984 64130906
Acute respiratory failure 23.29 10.88 174 361668 49760 64087130
Ankle arthroplasty 23.17 10.88 27 361815 879 64136011
Nocardiosis 23.15 10.88 69 361773 4698 64132192
Pneumonia bacterial 23.06 10.88 154 361688 14881 64122009
Exposure during pregnancy 23.05 10.88 302 361540 77373 64059517
Neck mass 23.02 10.88 62 361780 3982 64132908
Bradyphrenia 23.00 10.88 12 361830 9394 64127496
Chronic allograft nephropathy 22.93 10.88 35 361807 1486 64135404
Nephrogenic systemic fibrosis 22.86 10.88 3 361839 5889 64131001
Thrombotic microangiopathy 22.85 10.88 166 361676 16489 64120401
Micturition urgency 22.80 10.88 15 361827 10344 64126546
Amylase increased 22.74 10.88 13 361829 9672 64127218
Neuromyelitis optica spectrum disorder 22.69 10.88 26 361816 831 64136059
Device leakage 22.62 10.88 9 361833 8257 64128633
Hypernatraemia 22.59 10.88 21 361821 12168 64124722
Incoherent 22.56 10.88 6 361836 7112 64129778
Lymphoplasmacytoid lymphoma/immunocytoma 22.50 10.88 9 361833 41 64136849
Coronary artery bypass 22.47 10.88 3 361839 5812 64131078
Polyarthritis 22.46 10.88 111 361731 9604 64127286
Maternal exposure timing unspecified 22.43 10.88 48 361794 2659 64134231
Meningitis enteroviral 22.36 10.88 10 361832 63 64136827
Hyperbilirubinaemia 22.32 10.88 54 361788 21151 64115739
Blood calcium increased 22.25 10.88 10 361832 8532 64128358
Fibromyalgia 22.24 10.88 302 361540 35429 64101461
Immunosuppression 22.21 10.88 119 361723 10627 64126263
Duodenal ulcer 22.20 10.88 29 361813 14406 64122484
Human polyomavirus infection 22.20 10.88 28 361814 991 64135899
Pneumonia 22.18 10.88 3518 358324 556058 63580832
Retinitis 22.12 10.88 41 361801 2044 64134846
Lymphoproliferative disorder 22.12 10.88 71 361771 5032 64131858
Pulmonary toxicity 22.11 10.88 101 361741 8460 64128430
Pharyngeal paraesthesia 22.00 10.88 39 361803 1878 64135012
Ammonia increased 21.89 10.88 6 361836 6971 64129919
Wrong product administered 21.80 10.88 8 361834 7712 64129178
Oliguria 21.69 10.88 30 361812 14546 64122344
Pallor 21.68 10.88 128 361714 38653 64098237
Cardiac failure 21.61 10.88 571 361271 131802 64005088
Musculoskeletal pain 21.50 10.88 603 361239 80691 64056199
Haemoglobin decreased 21.49 10.88 885 360957 194178 63942712
Brain natriuretic peptide increased 21.40 10.88 8 361834 7625 64129265
Anovulatory cycle 21.40 10.88 11 361831 98 64136792
Gestational diabetes 21.32 10.88 3 361839 5587 64131303
Pulseless electrical activity 21.28 10.88 24 361818 12715 64124175
Arrhythmia 21.27 10.88 192 361650 52752 64084138
Malignant transformation 21.22 10.88 29 361813 1112 64135778
Genitourinary tract infection 21.21 10.88 15 361827 249 64136641
Peripheral coldness 21.20 10.88 27 361815 13557 64123333
Hypertriglyceridaemia 21.13 10.88 19 361823 11186 64125704
Pemphigoid 21.12 10.88 25 361817 12961 64123929
Mental impairment 21.11 10.88 37 361805 16306 64120584
Cholestasis 21.10 10.88 156 361686 44716 64092174
Haematuria 21.06 10.88 227 361615 60244 64076646
Sensitivity to weather change 21.04 10.88 84 361758 6630 64130260
Pulse absent 21.02 10.88 12 361830 8934 64127956
Nocturia 20.97 10.88 19 361823 11146 64125744
Personality change 20.96 10.88 11 361831 8582 64128308
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.89 10.88 49 361793 2887 64134003
Nerve injury 20.85 10.88 92 361750 7593 64129297
Marginal zone lymphoma recurrent 20.82 10.88 8 361834 32 64136858
Chest discomfort 20.79 10.88 494 361348 115612 64021278
Pulmonary mass 20.69 10.88 216 361626 23800 64113090
Groin pain 20.68 10.88 20 361822 11373 64125517
Impaired gastric emptying 20.65 10.88 101 361741 8703 64128187
Liver function test increased 20.63 10.88 265 361577 30705 64106185
Escherichia bacteraemia 20.60 10.88 72 361770 5331 64131559
Major depression 20.60 10.88 9 361833 7807 64129083
Cestode infection 20.51 10.88 15 361827 263 64136627
Blood albumin decreased 20.38 10.88 56 361786 21017 64115873
Extrasystoles 20.38 10.88 6 361836 6652 64130238
Drug level below therapeutic 20.27 10.88 8 361834 7376 64129514
Nail disorder 20.27 10.88 99 361743 8525 64128365
Engraftment syndrome 20.26 10.88 28 361814 1085 64135805
Polydipsia 20.26 10.88 4 361838 5817 64131073
Endophthalmitis 20.18 10.88 3 361839 5362 64131528
Rash papular 20.13 10.88 41 361801 17072 64119818
Multiple allergies 20.07 10.88 75 361767 5739 64131151
Hypovolaemia 20.06 10.88 35 361807 15451 64121439
Hypercapnia 20.06 10.88 9 361833 7685 64129205
Tooth disorder 20.02 10.88 203 361639 22199 64114691
Granuloma 19.95 10.88 82 361760 6559 64130331
Heavy menstrual bleeding 19.91 10.88 23 361819 12054 64124836
Blood thyroid stimulating hormone increased 19.88 10.88 9 361833 7645 64129245
Affect lability 19.81 10.88 13 361829 8977 64127913
Pseudomonal sepsis 19.79 10.88 69 361773 5103 64131787
Flank pain 19.72 10.88 38 361804 16151 64120739
Larynx irritation 19.66 10.88 11 361831 118 64136772
Muscle tightness 19.62 10.88 20 361822 11095 64125795
Carotid artery stenosis 19.61 10.88 10 361832 7931 64128959
Face oedema 19.60 10.88 72 361770 24689 64112201
Concussion 19.60 10.88 10 361832 7928 64128962
Eyelid oedema 19.58 10.88 24 361818 12255 64124635
Smear cervix abnormal 19.56 10.88 42 361800 2332 64134558
Product complaint 19.45 10.88 23 361819 11931 64124959
Neutrophil Pelger-Huet anomaly present 19.41 10.88 16 361826 337 64136553
Nasal cavity cancer 19.41 10.88 12 361830 157 64136733
Therapy change 19.33 10.88 6 361836 6428 64130462
Polyomavirus viraemia 19.33 10.88 28 361814 1134 64135756
Skin irritation 19.32 10.88 14 361828 9180 64127710
Breast cancer metastatic 19.30 10.88 8 361834 7161 64129729
Antineutrophil cytoplasmic antibody positive 19.24 10.88 26 361816 986 64135904
Potentiating drug interaction 19.22 10.88 10 361832 7842 64129048
Hyperreflexia 19.21 10.88 8 361834 7140 64129750
Sputum discoloured 19.17 10.88 45 361797 17811 64119079
Shock haemorrhagic 19.10 10.88 41 361801 16750 64120140
T-lymphocyte count increased 19.09 10.88 10 361832 93 64136797
Diaphragm muscle weakness 19.09 10.88 12 361830 162 64136728
Osteoporosis 19.04 10.88 337 361505 41743 64095147
Vaginal haemorrhage 19.02 10.88 51 361791 19293 64117597
Natural killer-cell leukaemia 19.00 10.88 10 361832 94 64136796
Erythema multiforme 19.00 10.88 37 361805 15664 64121226
Acquired C1 inhibitor deficiency 18.95 10.88 6 361836 11 64136879
Bladder transitional cell carcinoma 18.94 10.88 41 361801 2289 64134601
Glomerular filtration rate decreased 18.94 10.88 52 361790 19520 64117370
Cytomegalovirus gastritis 18.92 10.88 17 361825 404 64136486
Central nervous system fungal infection 18.88 10.88 17 361825 405 64136485
Troponin increased 18.88 10.88 36 361806 15363 64121527
Dyspnoea at rest 18.84 10.88 6 361836 6323 64130567
Injury 18.78 10.88 212 361630 55780 64081110
Allergic oedema 18.74 10.88 22 361820 722 64136168
Cardiac failure chronic 18.70 10.88 14 361828 9027 64127863
Pericardial effusion 18.68 10.88 136 361706 39118 64097772
Bone density abnormal 18.66 10.88 45 361797 2700 64134190
Vaccination failure 18.65 10.88 24 361818 867 64136023
Epstein-Barr viraemia 18.65 10.88 35 361807 1762 64135128
Renal impairment 18.62 10.88 596 361246 134421 64002469
Colitis ischaemic 18.60 10.88 29 361813 13385 64123505
Refractory cytopenia with multilineage dysplasia 18.60 10.88 14 361828 257 64136633
Metabolic encephalopathy 18.52 10.88 11 361831 8014 64128876
Cardiac pacemaker insertion 18.46 10.88 3 361839 5020 64131870
Arachnoiditis 18.41 10.88 21 361821 668 64136222
Complication of device insertion 18.41 10.88 3 361839 5009 64131881
Biopsy bone marrow abnormal 18.41 10.88 17 361825 419 64136471
Cryoglobulinaemia 18.38 10.88 21 361821 669 64136221
Proteinuria 18.37 10.88 237 361605 27486 64109404
Red blood cell count decreased 18.35 10.88 178 361664 48208 64088682
Rheumatoid lung 18.33 10.88 42 361800 2437 64134453
Infected seroma 18.33 10.88 9 361833 72 64136818
Citrobacter bacteraemia 18.29 10.88 6 361836 13 64136877
Haemorrhoids 18.21 10.88 71 361771 23930 64112960
Bone marrow infiltration 18.21 10.88 18 361824 484 64136406
Initial insomnia 18.19 10.88 5 361837 5799 64131091
Polyneuropathy 18.13 10.88 181 361661 19713 64117177
Blood pressure inadequately controlled 18.12 10.88 4 361838 5380 64131510
Drug level above therapeutic 18.10 10.88 8 361834 6893 64129997
Oral herpes 18.04 10.88 197 361645 21955 64114935
Enterovirus myocarditis 18.03 10.88 5 361837 4 64136886
Mass 18.02 10.88 147 361695 15129 64121761
Aplasia 17.93 10.88 82 361760 6871 64130019
Ketoacidosis 17.93 10.88 8 361834 6855 64130035
Blood immunoglobulin M increased 17.88 10.88 17 361825 435 64136455
Polyuria 17.85 10.88 27 361815 12616 64124274
Cholesteatoma 17.81 10.88 10 361832 108 64136782
Gout 17.79 10.88 61 361781 21352 64115538
Herpes zoster infection neurological 17.78 10.88 11 361831 144 64136746
Epstein-Barr virus associated lymphoma 17.78 10.88 24 361818 909 64135981
Infective exacerbation of chronic obstructive airways disease 17.69 10.88 41 361801 2397 64134493
Viral upper respiratory tract infection 17.69 10.88 92 361750 8123 64128767
Rib fracture 17.68 10.88 72 361770 23966 64112924
Device failure 17.66 10.88 5 361837 5687 64131203
Clonus 17.62 10.88 6 361836 6061 64130829
Gastrointestinal sounds abnormal 17.56 10.88 3 361839 4840 64132050
Premenstrual syndrome 17.56 10.88 18 361824 506 64136384
Escherichia sepsis 17.38 10.88 83 361759 7082 64129808
Meningitis tuberculous 17.37 10.88 26 361816 1085 64135805
Pneumonia klebsiella 17.35 10.88 56 361786 3981 64132909
Fluoride increased 17.34 10.88 9 361833 82 64136808
Leukaemic lymphoma 17.34 10.88 9 361833 82 64136808
Overlap syndrome 17.29 10.88 21 361821 715 64136175
Mean cell volume decreased 17.26 10.88 51 361791 3455 64133435
Embolic stroke 17.26 10.88 8 361834 6703 64130187
Non-cardiac chest pain 17.25 10.88 14 361828 8666 64128224
Gastritis erosive 17.24 10.88 17 361825 9578 64127312
Essential hypertension 17.20 10.88 4 361838 5190 64131700
Anuria 17.17 10.88 52 361790 18912 64117978
Human rhinovirus test positive 17.14 10.88 16 361826 400 64136490
Eosinophilia 17.13 10.88 134 361708 37942 64098948
Disorder of orbit 17.13 10.88 10 361832 117 64136773
Encephalitis 17.07 10.88 125 361717 12446 64124444
Prostatic abscess 17.06 10.88 15 361827 346 64136544
Tooth infection 16.96 10.88 140 361702 14461 64122429
Occult blood positive 16.95 10.88 7 361835 6280 64130610
Hepatitis D 16.82 10.88 7 361835 36 64136854
Enthesopathy 16.81 10.88 102 361740 9536 64127354
Acute flaccid myelitis 16.76 10.88 4 361838 0 64136890
Prolymphocytic leukaemia 16.76 10.88 4 361838 0 64136890
Vulvovaginal ulceration 16.76 10.88 4 361838 0 64136890
Noninfectious myelitis 16.68 10.88 6 361836 19 64136871
Mixed liver injury 16.67 10.88 5 361837 5476 64131414
Central nervous system vasculitis 16.62 10.88 26 361816 1128 64135762
Heart rate abnormal 16.60 10.88 64 361778 4971 64131919
Coronary artery occlusion 16.58 10.88 33 361809 13858 64123032
Organising pneumonia 16.55 10.88 97 361745 8958 64127932
Stem cell transplant 16.54 10.88 50 361792 3431 64133459
Glomerulonephritis rapidly progressive 16.52 10.88 28 361814 1300 64135590
Hepatitis B DNA increased 16.49 10.88 19 361823 611 64136279
Adenocarcinoma gastric 16.47 10.88 31 361811 1564 64135326
Hypovolaemic shock 16.44 10.88 20 361822 10246 64126644
Forced expiratory volume decreased 16.44 10.88 9 361833 6858 64130032
Petit mal epilepsy 16.41 10.88 4 361838 5028 64131862
Osteonecrosis 16.41 10.88 92 361750 28137 64108753
Viral cardiomyopathy 16.36 10.88 7 361835 39 64136851
Colitis ulcerative 16.30 10.88 70 361772 22958 64113932
Intestinal atresia 16.29 10.88 8 361834 64 64136826
Hypoxic-ischaemic encephalopathy 16.23 10.88 10 361832 7142 64129748
Social avoidant behaviour 16.14 10.88 3 361839 4554 64132336
Peptic ulcer 16.11 10.88 5 361837 5358 64131532
Mucocutaneous haemorrhage 16.11 10.88 11 361831 172 64136718
Acute biphenotypic leukaemia 16.10 10.88 10 361832 132 64136758
Myelopathy 16.07 10.88 54 361788 3920 64132970
Atrial fibrillation 16.04 10.88 790 361052 170299 63966591
Campylobacter infection 16.03 10.88 27 361815 1247 64135643
Blood chloride decreased 15.97 10.88 11 361831 7405 64129485
Metastases to lung 15.96 10.88 39 361803 15225 64121665
Pain of skin 15.93 10.88 18 361824 9529 64127361
B-lymphocyte count abnormal 15.88 10.88 8 361834 68 64136822
Myelitis 15.83 10.88 36 361806 2078 64134812
Electrocardiogram T wave inversion 15.75 10.88 4 361838 4890 64132000
Urine abnormality 15.75 10.88 11 361831 7351 64129539
Wrist surgery 15.75 10.88 20 361822 713 64136177
Amyotrophic lateral sclerosis 15.73 10.88 31 361811 1619 64135271
Seasonal allergy 15.65 10.88 26 361816 11700 64125190
Supraventricular tachycardia 15.62 10.88 54 361788 18853 64118037
Combined immunodeficiency 15.59 10.88 9 361833 103 64136787
Rash macular 15.56 10.88 74 361768 23611 64113279
Red cell fragmentation syndrome 15.54 10.88 7 361835 45 64136845
Leukocytosis 15.53 10.88 136 361706 37604 64099286
Ganglioneuroma 15.53 10.88 10 361832 141 64136749
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 15.51 10.88 5 361837 10 64136880
Lichen sclerosus 15.49 10.88 22 361820 875 64136015
White blood cell count abnormal 15.43 10.88 61 361781 4793 64132097
Bundle branch block right 15.42 10.88 21 361821 10248 64126642
Splenic candidiasis 15.31 10.88 8 361834 74 64136816
Neoplasm recurrence 15.29 10.88 51 361791 3688 64133202
Human herpesvirus 8 infection 15.21 10.88 24 361818 1049 64135841
Fracture 15.20 10.88 54 361788 18701 64118189
Glottis carcinoma 15.19 10.88 5 361837 11 64136879
Isosporiasis 15.08 10.88 9 361833 110 64136780
Infusion site erythema 15.06 10.88 10 361832 6863 64130027
Prerenal failure 15.04 10.88 46 361796 3176 64133714
Scedosporium infection 15.02 10.88 26 361816 1228 64135662
Primary amyloidosis 15.01 10.88 9 361833 111 64136779
Tongue pruritus 14.99 10.88 16 361826 472 64136418
Mucormycosis 14.98 10.88 81 361761 7260 64129630
Disseminated cytomegaloviral infection 14.97 10.88 15 361827 410 64136480
Limb mass 14.93 10.88 44 361798 2977 64133913
Mean cell haemoglobin decreased 14.92 10.88 54 361788 4068 64132822
Diarrhoea haemorrhagic 14.89 10.88 25 361817 11202 64125688
Personality disorder 14.88 10.88 4 361838 4707 64132183
Hypothyroidism 14.85 10.88 150 361692 40307 64096583
Cytomegalovirus enterocolitis 14.82 10.88 27 361815 1328 64135562
Ecthyma 14.79 10.88 18 361824 614 64136276
Lip pruritus 14.78 10.88 19 361823 686 64136204
Acute lung injury 14.68 10.88 41 361801 2690 64134200
CD8 lymphocytes decreased 14.67 10.88 12 361830 250 64136640
Alcohol poisoning 14.65 10.88 3 361839 4252 64132638
Ascites 14.63 10.88 252 361590 61749 64075141
Exercise tolerance decreased 14.63 10.88 13 361829 7697 64129193
Bacille Calmette-Guerin scar reactivation 14.55 10.88 6 361836 30 64136860
Therapy responder 14.51 10.88 15 361827 426 64136464
Superior mesenteric artery syndrome 14.51 10.88 10 361832 159 64136731
Large intestine polyp 14.49 10.88 24 361818 10813 64126077
Hepatic steatosis 14.48 10.88 108 361734 30899 64105991
Taste disorder 14.46 10.88 19 361823 9414 64127476
Pruritus 14.44 10.88 1533 360309 310867 63826023
Allergy to chemicals 14.43 10.88 23 361819 1014 64135876
Jaw disorder 14.43 10.88 4 361838 4613 64132277
International normalised ratio abnormal 14.37 10.88 5 361837 4983 64131907
Chromosomal deletion 14.36 10.88 8 361834 85 64136805
Vitreous floaters 14.34 10.88 9 361833 6364 64130526
Neoplasm malignant 14.29 10.88 206 361636 24482 64112408
Bilirubin conjugated increased 14.28 10.88 5 361837 4963 64131927
Multiple system atrophy 14.27 10.88 14 361828 373 64136517
Oxygen consumption increased 14.26 10.88 4 361838 4577 64132313
Cytokine storm 14.21 10.88 21 361821 866 64136024
Muscle disorder 14.20 10.88 5 361837 4946 64131944
Metastases to central nervous system 14.19 10.88 36 361806 13876 64123014
Nystagmus 14.17 10.88 18 361824 9050 64127840
Muscle strain 14.17 10.88 15 361827 8179 64128711
Hypomania 14.14 10.88 7 361835 5647 64131243
Pruritus allergic 14.12 10.88 21 361821 871 64136019
White blood cell count increased 14.10 10.88 273 361569 65741 64071149
Aspiration 14.10 10.88 48 361794 16837 64120053
Diplopia 14.09 10.88 90 361752 26675 64110215
Hepatitis B surface antibody positive 14.08 10.88 11 361831 214 64136676
Respiratory rate increased 14.01 10.88 161 361681 18170 64118720
Metastases to bone marrow 14.00 10.88 18 361824 650 64136240
Cellulitis gangrenous 13.97 10.88 12 361830 268 64136622
Bone marrow reticulin fibrosis 13.97 10.88 12 361830 268 64136622
Anorectal varices 13.94 10.88 6 361836 34 64136856
CD4 lymphocytes increased 13.93 10.88 12 361830 269 64136621
Myelofibrosis 13.90 10.88 35 361807 2158 64134732
Paraesthesia ear 13.89 10.88 10 361832 171 64136719
Spirochaetal infection 13.86 10.88 5 361837 16 64136874
Scleroderma renal crisis 13.82 10.88 14 361828 388 64136502
Feeling jittery 13.81 10.88 24 361818 10611 64126279
Catheter site erythema 13.73 10.88 5 361837 4844 64132046
Plasma cell myeloma recurrent 13.72 10.88 3 361839 4062 64132828
Myelitis transverse 13.70 10.88 29 361813 1594 64135296
Ocular lymphoma 13.67 10.88 8 361834 94 64136796
Refractory cytopenia with unilineage dysplasia 13.62 10.88 20 361822 820 64136070
Ischaemic cardiomyopathy 13.62 10.88 11 361831 6827 64130063
Diverticulum 13.58 10.88 34 361808 13164 64123726
Microscopic polyangiitis 13.57 10.88 12 361830 279 64136611
Panic reaction 13.54 10.88 3 361839 4024 64132866
Faecaloma 13.52 10.88 21 361821 9707 64127183
Renal transplant failure 13.49 10.88 29 361813 1611 64135279
Rhinitis 13.47 10.88 105 361737 10660 64126230
Infective thrombosis 13.46 10.88 7 361835 64 64136826
Cell-mediated immune deficiency 13.46 10.88 8 361834 97 64136793
Alanine aminotransferase abnormal 13.38 10.88 75 361767 6813 64130077
Head discomfort 13.37 10.88 29 361813 11805 64125085
Central nervous system infection 13.33 10.88 24 361818 1170 64135720
Hiatus hernia 13.32 10.88 62 361780 19895 64116995
Internal haemorrhage 13.30 10.88 14 361828 7653 64129237
Lung diffusion test decreased 13.30 10.88 24 361818 1172 64135718
Capillaritis 13.29 10.88 11 361831 233 64136657
Eye irritation 13.29 10.88 45 361797 15811 64121079
Gastroenteritis clostridial 13.24 10.88 19 361823 763 64136127
Ocular icterus 13.23 10.88 6 361836 5092 64131798
Leukaemia cutis 13.22 10.88 9 361833 140 64136750
Device occlusion 13.21 10.88 22 361820 9891 64126999
Primary immunodeficiency syndrome 13.19 10.88 7 361835 67 64136823
Nail pigmentation 13.19 10.88 12 361830 290 64136600
Coronary artery stenosis 13.18 10.88 27 361815 11221 64125669
Follicle centre lymphoma, follicular grade I, II, III recurrent 13.12 10.88 4 361838 6 64136884
Apnoea 13.10 10.88 24 361818 10398 64126492
Blood creatine increased 13.08 10.88 16 361826 8176 64128714
Retroperitoneal lymphadenopathy 13.06 10.88 21 361821 933 64135957
Transient hypogammaglobulinaemia of infancy 13.01 10.88 6 361836 41 64136849
Pain in jaw 13.01 10.88 156 361686 40599 64096291
Blood pressure decreased 12.98 10.88 376 361466 85823 64051067
Pulmonary sarcoidosis 12.97 10.88 23 361819 1108 64135782
Stupor 12.93 10.88 9 361833 6026 64130864
Procedural complication 12.90 10.88 13 361829 7252 64129638
Chronic myeloid leukaemia 12.90 10.88 45 361797 3329 64133561
Chest wall tumour 12.89 10.88 6 361836 42 64136848
Gastric pneumatosis 12.82 10.88 5 361837 21 64136869
Helicobacter sepsis 12.82 10.88 5 361837 21 64136869
Mucocutaneous leishmaniasis 12.82 10.88 14 361828 424 64136466
Post procedural haemorrhage 12.81 10.88 32 361810 12399 64124491
Dermatitis atopic 12.80 10.88 3 361839 3873 64133017
Parosmia 12.78 10.88 5 361837 4635 64132255
Laryngeal stenosis 12.78 10.88 19 361823 788 64136102
Myeloproliferative neoplasm 12.76 10.88 20 361822 869 64136021
Anal prolapse 12.76 10.88 7 361835 72 64136818
Atypical fibroxanthoma 12.74 10.88 10 361832 196 64136694
Haemodynamic instability 12.72 10.88 42 361800 14870 64122020
Postural tremor 12.72 10.88 16 361826 565 64136325
Extravasation 12.67 10.88 43 361799 3137 64133753
Conus medullaris syndrome 12.64 10.88 5 361837 22 64136868
Blood glucose fluctuation 12.61 10.88 9 361833 5946 64130944
Aortic arteriosclerosis 12.58 10.88 14 361828 7462 64129428
Refusal of treatment by patient 12.58 10.88 17 361825 8322 64128568
Encephalitis eastern equine 12.57 10.88 3 361839 0 64136890
Interchange of vaccine products 12.57 10.88 3 361839 0 64136890
Gallbladder disorder 12.53 10.88 51 361791 16979 64119911
Cholecystectomy 12.50 10.88 16 361826 8016 64128874
Abdominal abscess 12.48 10.88 69 361773 6235 64130655
Diabetic neuropathy 12.48 10.88 8 361834 5593 64131297
Non-Hodgkin's lymphoma recurrent 12.46 10.88 5 361837 23 64136867
Bronchopneumopathy 12.46 10.88 16 361826 577 64136313
Pre-eclampsia 12.44 10.88 10 361832 6221 64130669
Extranodal marginal zone B-cell lymphoma (MALT type) 12.41 10.88 15 361827 508 64136382
Knee operation 12.41 10.88 5 361837 4552 64132338
Craniocerebral injury 12.36 10.88 4 361838 4172 64132718
Injection site inflammation 12.35 10.88 43 361799 3178 64133712
Cushingoid 12.35 10.88 79 361763 7524 64129366
Feeling drunk 12.32 10.88 4 361838 4163 64132727
Chylothorax 12.31 10.88 16 361826 584 64136306
Haemarthrosis 12.31 10.88 7 361835 5222 64131668
Chronic hepatitis 12.30 10.88 24 361818 1244 64135646
Iodine allergy 12.30 10.88 15 361827 513 64136377
Dry mouth 12.26 10.88 252 361590 60166 64076724
Febrile infection 12.25 10.88 40 361802 2861 64134029
Hand fracture 12.24 10.88 6 361836 4868 64132022
Neuroendocrine carcinoma of the skin 12.21 10.88 21 361821 987 64135903
Drug eruption 12.20 10.88 277 361565 35859 64101031
Small intestinal perforation 12.20 10.88 37 361805 2543 64134347
Graft versus host disease in gastrointestinal tract 12.19 10.88 63 361779 5549 64131341
Anticipatory anxiety 12.15 10.88 11 361831 264 64136626
Herpes virus infection 12.14 10.88 68 361774 6176 64130714
Blood stem cell transplant failure 12.14 10.88 15 361827 520 64136370
Device adhesion issue 12.12 10.88 7 361835 5179 64131711
Viral load increased 12.08 10.88 36 361806 2451 64134439
Neutropenic infection 12.08 10.88 31 361811 1934 64134956
Blood bicarbonate decreased 12.05 10.88 6 361836 4823 64132067
Foetal exposure during pregnancy 12.04 10.88 5 361837 4471 64132419
Pleocytosis 12.04 10.88 22 361820 1085 64135805
Marrow hyperplasia 12.00 10.88 25 361817 1359 64135531
Toxic encephalopathy 11.99 10.88 23 361819 9792 64127098
Skin abrasion 11.98 10.88 30 361812 11615 64125275
Photophobia 11.98 10.88 53 361789 17240 64119650
Morphoea 11.92 10.88 13 361829 393 64136497
Positron emission tomogram abnormal 11.91 10.88 11 361831 271 64136619
Epstein Barr virus positive mucocutaneous ulcer 11.89 10.88 17 361825 680 64136210
Haemophilus infection 11.86 10.88 30 361812 1855 64135035
Evans syndrome 11.84 10.88 13 361829 396 64136494
Rheumatoid factor 11.83 10.88 8 361834 123 64136767
Emotional disorder 11.83 10.88 34 361808 12573 64124317
B-lymphocyte abnormalities 11.81 10.88 5 361837 27 64136863
Immunisation 11.80 10.88 4 361838 10 64136880
Graft versus host disease 11.79 10.88 124 361718 13689 64123201
Mouth swelling 11.79 10.88 7 361835 5100 64131790
Peripheral vascular disorder 11.78 10.88 14 361828 7247 64129643
Abdominal lymphadenopathy 11.77 10.88 22 361820 1104 64135786
Skin plaque 11.77 10.88 20 361822 8920 64127970
Neck surgery 11.76 10.88 26 361816 1473 64135417
Cystitis escherichia 11.75 10.88 14 361828 467 64136423
Pneumonia escherichia 11.73 10.88 18 361824 768 64136122
Peripheral ischaemia 11.73 10.88 18 361824 8360 64128530
Faecal calprotectin increased 11.67 10.88 3 361839 3637 64133253
Mediastinum neoplasm 11.63 10.88 7 361835 87 64136803
Passenger lymphocyte syndrome 11.63 10.88 7 361835 87 64136803
Aspergillosis oral 11.62 10.88 6 361836 54 64136836
Autoimmune neutropenia 11.61 10.88 13 361829 405 64136485
Rheumatoid factor increased 11.61 10.88 25 361817 1391 64135499
Hypertonia 11.60 10.88 11 361831 6314 64130576
Graft versus host disease in skin 11.59 10.88 60 361782 5287 64131603
Thyroiditis 11.59 10.88 3 361839 3621 64133269
Blood phosphorus decreased 11.59 10.88 9 361833 5696 64131194
Atrioventricular block 11.57 10.88 32 361810 11983 64124907
Granulomatosis with polyangiitis 11.57 10.88 32 361810 2088 64134802
Magnesium deficiency 11.53 10.88 15 361827 548 64136342
Haemorrhage subcutaneous 11.53 10.88 5 361837 4356 64132534
Marginal zone lymphoma 11.53 10.88 6 361836 55 64136835
Abdominal tenderness 11.52 10.88 22 361820 9383 64127507
Opportunistic infection 11.50 10.88 37 361805 2625 64134265
Anal incontinence 11.50 10.88 45 361797 15151 64121739
Angiosarcoma 11.48 10.88 13 361829 410 64136480
Skin infection 11.46 10.88 132 361710 14905 64121985
Low density lipoprotein increased 11.45 10.88 16 361826 7724 64129166
Secretion discharge 11.42 10.88 32 361810 11932 64124958
Hyperammonaemia 11.42 10.88 24 361818 9880 64127010
Pneumaturia 11.38 10.88 5 361837 30 64136860
Feeding disorder 11.37 10.88 36 361806 12913 64123977
Malignant melanoma 11.36 10.88 117 361725 12847 64124043
Pneumonia pseudomonal 11.32 10.88 56 361786 4847 64132043
Amenorrhoea 11.28 10.88 12 361830 6527 64130363
Rheumatic disorder 11.27 10.88 26 361816 1515 64135375
Sinus node dysfunction 11.26 10.88 13 361829 6815 64130075
Osteosclerosis 11.24 10.88 44 361798 3442 64133448
Tularaemia 11.23 10.88 7 361835 93 64136797
Neutrophil percentage decreased 11.19 10.88 17 361825 719 64136171
Metastases to spleen 11.18 10.88 14 361828 492 64136398
Gingival swelling 11.17 10.88 4 361838 3916 64132974
Limb operation 11.17 10.88 38 361804 2776 64134114
Gastric cyst 11.17 10.88 7 361835 94 64136796
Multiple organ dysfunction syndrome 11.13 10.88 685 361157 100728 64036162
Wound infection 11.12 10.88 130 361712 14734 64122156
Cutaneous T-cell lymphoma recurrent 11.08 10.88 6 361836 60 64136830
Adenoviral haemorrhagic cystitis 11.07 10.88 14 361828 497 64136393
Movement disorder 11.07 10.88 75 361767 21925 64114965
Joint effusion 11.06 10.88 120 361722 13353 64123537
Breast pain 11.05 10.88 14 361828 7047 64129843
Lymphocytic lymphoma 11.04 10.88 7 361835 96 64136794
Angina pectoris 11.03 10.88 182 361660 44899 64091991
Skin papilloma 11.02 10.88 58 361784 5145 64131745
Systemic candida 11.01 10.88 59 361783 5270 64131620
B-lymphocyte count increased 11.00 10.88 8 361834 139 64136751
Respiratory tract infection fungal 11.00 10.88 21 361821 1071 64135819
Injection site discomfort 10.99 10.88 5 361837 4236 64132654
Dyslipidaemia 10.99 10.88 22 361820 9220 64127670
Lower limb fracture 10.98 10.88 39 361803 13506 64123384
Streptococcal bacteraemia 10.95 10.88 40 361802 3027 64133863

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
CD20 (Clusters of Differentiation 20) inhibitors
FDA MoA N0000175078 CD20-directed Antibody Interactions
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
FDA EPC N0000175657 CD20-directed Cytolytic Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pemphigus foliaceus indication 35154004
Pemphigus vulgaris indication 49420001 DOID:0060851
Rheumatoid arthritis indication 69896004 DOID:7148
Thrombotic thrombocytopenic purpura indication 78129009 DOID:10772
Systemic sclerosis indication 89155008 DOID:418
Chronic lymphoid leukemia, disease indication 92814006
Non-Hodgkin's lymphoma indication 118601006
Granulomatosis with polyangiitis indication 195353004 DOID:12132
Microscopic polyarteritis nodosa indication 239928004
Microscopic polyangiitis indication 1144805008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
B-lymphocyte antigen CD20 Surface antigen ANTIBODY BINDING Kd 8.51 IUPHAR DRUG LABEL

External reference:

IDSource
D02994 KEGG_DRUG
4021104 VUID
N0000148560 NUI
4021104 VANDF
CHEMBL1201576 ChEMBL_ID
6780 IUPHAR_LIGAND_ID
7609 INN_ID
DB00073 DRUGBANK_ID
4F4X42SYQ6 UNII
121191 RXNORM
11468 MMSL
5432 MMSL
d04255 MMSL
108809004 SNOMEDCT_US
386919002 SNOMEDCT_US
D000069283 MESH_DESCRIPTOR_UI
C0393022 UMLSCUI
007236 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0238 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0249 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 30 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-108 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-109 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-224 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-224 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-326 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-326 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 32 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-103 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-104 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections