rituximab Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
chimeric origin	4975	174722-31-7

Description:

Molecule	Description
Synonyms: rituximab rituxan MabThera	A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 25, 2008	PMDA	Bayer Yakuhin, Nihon Schering, Zenyaku Kogyo
Nov. 26, 1997	FDA	GENENTECH
June 2, 1998	EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	4710.87	11.15	6008	237461	234207	46208386
Drug ineffective	3435.70	11.15	9435	234034	668403	45774190
Contraindicated product administered	2355.28	11.15	2473	240996	77474	46365119
Drug intolerance	1953.74	11.15	3061	240408	143988	46298605
Treatment failure	1931.78	11.15	2402	241067	90685	46351908
Infusion related reaction	1562.39	11.15	2261	241208	98947	46343646
Joint swelling	1237.30	11.15	2695	240774	163378	46279215
Pemphigus	1205.95	11.15	1329	242140	43945	46398648
Intentional product use issue	1168.10	11.15	1408	242061	51372	46391221
Off label use	1098.86	11.15	4393	239076	375448	46067145
Progressive multifocal leukoencephalopathy	1018.37	11.15	671	242798	10675	46431918
Systemic lupus erythematosus	1017.76	11.15	1465	242004	63715	46378878
Synovitis	927.64	11.15	1355	242114	59720	46382873
Therapeutic product effect decreased	795.86	11.15	1493	241976	81108	46361485
Hand deformity	731.57	11.15	902	242567	33672	46408921
Completed suicide	722.33	11.15	7	243462	145913	46296680
Glossodynia	684.50	11.15	992	242477	43381	46399212
Arthropathy	625.34	11.15	1371	242098	83329	46359264
Hypogammaglobulinaemia	578.32	11.15	358	243111	5080	46437513
Product dose omission issue	558.41	11.15	102	243367	168418	46274175
Rheumatoid factor positive	551.99	11.15	605	242864	19856	46422737
Alopecia	542.47	11.15	1970	241499	160444	46282149
Febrile neutropenia	537.33	11.15	1383	242086	93244	46349349
Abdominal discomfort	529.94	11.15	1863	241606	149302	46293291
Infection	517.94	11.15	1703	241766	131889	46310704
Drug interaction	490.14	11.15	223	243246	202871	46239722
Anti-cyclic citrullinated peptide antibody positive	463.33	11.15	535	242934	18610	46423983
Toxicity to various agents	406.95	11.15	306	243163	211460	46231133
Diffuse large B-cell lymphoma recurrent	396.42	11.15	181	243288	1311	46441282
Product use in unapproved indication	386.29	11.15	1191	242278	89082	46353511
Swelling	385.93	11.15	1475	241994	123036	46319557
Dizziness	383.82	11.15	747	242722	339667	46102926
Hepatic enzyme increased	378.19	11.15	1109	242360	80678	46361915
Red blood cell sedimentation rate increased	369.37	11.15	523	242946	22366	46420227
Loss of personal independence in daily activities	366.85	11.15	876	242593	56307	46386286
Musculoskeletal stiffness	365.98	11.15	1234	242235	96759	46345834
Overdose	361.73	11.15	51	243418	101928	46340665
Injection site pain	356.62	11.15	64	243405	107088	46335505
Fall	337.42	11.15	762	242707	328335	46114258
Neutropenia	323.37	11.15	1541	241928	141663	46300930
Intentional overdose	321.74	11.15	3	243466	64941	46377652
Anxiety	314.84	11.15	291	243178	181666	46260927
Drug abuse	313.79	11.15	3	243466	63405	46379188
Arthralgia	303.57	11.15	3067	240402	361536	46081057
C-reactive protein increased	289.68	11.15	814	242655	57776	46384817
Pain	277.72	11.15	3744	239725	473204	45969389
Feeling abnormal	263.67	11.15	163	243306	124897	46317696
Vomiting	256.39	11.15	1354	242115	451440	45991153
Wound	253.50	11.15	636	242833	42166	46400427
Diffuse large B-cell lymphoma	252.26	11.15	225	243244	5713	46436880
Bone erosion	250.79	11.15	277	243192	9166	46433427
C-reactive protein abnormal	246.33	11.15	417	243052	20853	46421740
Acute kidney injury	237.47	11.15	551	242918	235304	46207289
Drug hypersensitivity	236.22	11.15	2119	241350	241706	46200887
Therapeutic product effect incomplete	230.64	11.15	912	242557	77241	46365352
Cardiac failure congestive	225.38	11.15	98	243371	91652	46350941
Confusional state	220.66	11.15	307	243162	159585	46283008
Hypersensitivity	220.45	11.15	1440	242029	148881	46293712
Diarrhoea	216.09	11.15	1875	241594	557727	45884866
Product use issue	213.10	11.15	1018	242451	93626	46348967
Pericarditis	207.47	11.15	414	243055	23513	46419080
Oedema peripheral	206.36	11.15	321	243148	159385	46283208
Muscle spasms	202.25	11.15	206	243263	122907	46319686
Hepatitis B	200.17	11.15	161	243308	3532	46439061
Constipation	196.65	11.15	381	243088	173716	46268877
Dehydration	193.68	11.15	334	243135	159206	46283387
Panniculitis	192.12	11.15	190	243279	5514	46437079
Suicide attempt	191.68	11.15	29	243440	55007	46387586
Dyspnoea	187.24	11.15	1754	241715	513794	45928799
B-lymphocyte count decreased	186.49	11.15	89	243380	721	46441872
Ill-defined disorder	181.77	11.15	420	243049	26407	46416186
Hyponatraemia	179.97	11.15	158	243311	101174	46341419
Rheumatoid nodule	177.40	11.15	227	243242	8793	46433800
Throat irritation	176.95	11.15	435	243034	28466	46414127
Herpes zoster	175.82	11.15	761	242708	67111	46375482
Granuloma skin	174.88	11.15	145	243324	3325	46439268
Inflammation	174.65	11.15	606	242863	48175	46394418
Serum sickness	173.89	11.15	126	243343	2352	46440241
Pneumocystis jirovecii pneumonia	172.67	11.15	296	243173	14952	46427641
Rhabdomyolysis	171.82	11.15	12	243457	41897	46400696
Blood parathyroid hormone decreased	170.42	11.15	158	243311	4223	46438370
Wrong technique in product usage process	169.53	11.15	38	243431	54384	46388209
Post transplant lymphoproliferative disorder	165.56	11.15	147	243322	3709	46438884
Decreased appetite	165.14	11.15	492	242977	193344	46249249
Hospitalisation	164.94	11.15	62	243407	63323	46379270
Tremor	163.55	11.15	218	243251	115421	46327172
Injection site erythema	162.44	11.15	93	243376	74334	46368259
Cytomegalovirus infection	162.19	11.15	318	243151	17826	46424767
Hip arthroplasty	158.96	11.15	315	243154	17797	46424796
Pulmonary fibrosis	158.09	11.15	334	243135	19758	46422835
Blood pressure fluctuation	156.32	11.15	429	243040	30019	46412574
Myelodysplastic syndrome	156.05	11.15	288	243181	15423	46427170
International normalised ratio increased	155.92	11.15	28	243441	46855	46395738
Suicidal ideation	155.57	11.15	50	243419	56332	46386261
Diffuse large B-cell lymphoma refractory	154.77	11.15	83	243386	881	46441712
Inappropriate schedule of product administration	154.09	11.15	73	243396	64940	46377653
Rash	153.28	11.15	2660	240809	353852	46088741
Blood pressure diastolic abnormal	152.43	11.15	176	243293	6118	46436475
Hypoglycaemia	146.80	11.15	50	243419	54299	46388294
Electrocardiogram QT prolonged	144.32	11.15	44	243425	51281	46391312
Seizure	143.53	11.15	264	243205	122790	46319803
Bradycardia	143.04	11.15	84	243385	66214	46376379
Incorrect dose administered	141.48	11.15	32	243437	45518	46397075
Plasma cell myeloma	140.68	11.15	30	243439	44448	46398145
Myalgia	140.11	11.15	268	243201	122820	46319773
Therapeutic response decreased	138.29	11.15	517	242952	42628	46399965
Hyperkalaemia	138.09	11.15	46	243423	50663	46391930
Depressed level of consciousness	137.01	11.15	39	243430	47530	46395063
Intentional product misuse	136.92	11.15	38	243431	47090	46395503
Blood pressure systolic abnormal	136.52	11.15	156	243313	5361	46437232
Joint stiffness	136.24	11.15	379	243090	26729	46415864
Tumour lysis syndrome	135.89	11.15	178	243291	7058	46435535
Cardio-respiratory arrest	134.71	11.15	72	243397	59797	46382796
Musculoskeletal deformity	134.50	11.15	71	243398	728	46441865
Demyelination	134.49	11.15	157	243312	5523	46437070
No adverse event	131.99	11.15	436	243033	33795	46408798
Cardiac arrest	131.31	11.15	167	243302	90232	46352361
Somnolence	129.89	11.15	402	243067	156119	46286474
B-cell lymphoma recurrent	129.42	11.15	57	243412	375	46442218
Vision blurred	129.02	11.15	135	243334	79573	46363020
Product quality issue	128.30	11.15	17	243452	35631	46406962
Maternal exposure during pregnancy	127.56	11.15	944	242525	101605	46340988
JC virus infection	126.97	11.15	89	243380	1573	46441020
Foot deformity	126.70	11.15	261	243208	15164	46427429
Injection site pruritus	125.30	11.15	27	243442	39716	46402877
Chronic lymphocytic leukaemia	123.41	11.15	110	243359	2790	46439803
Skin necrosis	123.40	11.15	186	243283	8418	46434175
Breast cancer stage III	122.89	11.15	81	243388	1288	46441305
Agitation	122.70	11.15	68	243401	55347	46387246
Gastrooesophageal reflux disease	122.49	11.15	124	243345	74220	46368373
Arthritis	121.42	11.15	754	242715	76562	46366031
Coeliac disease	120.51	11.15	167	243302	6994	46435599
Multiple sclerosis relapse	120.46	11.15	35	243434	42090	46400503
Drug tolerance decreased	118.36	11.15	110	243359	2949	46439644
Injection site swelling	116.25	11.15	33	243436	40294	46402299
Sciatica	115.07	11.15	285	243184	18735	46423858
Contrast media allergy	113.93	11.15	86	243383	1713	46440880
Hallucination	112.48	11.15	60	243409	49891	46392702
Ear pruritus	111.89	11.15	91	243378	2029	46440564
Helicobacter infection	111.39	11.15	211	243258	11525	46431068
Elbow deformity	111.25	11.15	76	243393	1286	46441307
Abdominal pain	110.49	11.15	724	242745	229307	46213286
Knee arthroplasty	110.30	11.15	322	243147	23343	46419250
Insomnia	110.05	11.15	464	243005	164460	46278133
Death	109.60	11.15	1170	242299	334378	46108215
Respiratory arrest	108.61	11.15	22	243447	33794	46408799
Anaphylactic reaction	108.57	11.15	556	242913	52556	46390037
Sleep disorder	107.89	11.15	507	242962	46288	46396305
Disease recurrence	107.78	11.15	273	243196	18198	46424395
B-cell lymphoma	107.75	11.15	108	243361	3186	46439407
Secondary immunodeficiency	107.53	11.15	66	243403	921	46441672
Gastrointestinal haemorrhage	107.20	11.15	148	243321	77225	46365368
Emotional distress	105.05	11.15	17	243452	30690	46411903
Lactic acidosis	104.95	11.15	24	243445	33885	46408708
Disability	104.29	11.15	189	243280	9978	46432615
Grip strength decreased	103.99	11.15	172	243297	8434	46434159
Cerebrovascular accident	103.15	11.15	234	243235	100805	46341788
Granulomatosis with polyangiitis	102.88	11.15	81	243388	1721	46440872
Asthma	102.68	11.15	201	243268	91341	46351252
Nausea	102.25	11.15	2769	240700	684685	45757908
Chronic lymphocytic leukaemia recurrent	102.16	11.15	39	243430	167	46442426
Memory impairment	102.14	11.15	153	243316	77184	46365409
Staphylococcal bacteraemia	102.13	11.15	127	243342	4777	46437816
Basal cell carcinoma	101.54	11.15	285	243184	20202	46422391
Metabolic acidosis	100.76	11.15	38	243431	38742	46403851
SLE arthritis	100.71	11.15	54	243415	573	46442020
White blood cell count abnormal	100.67	11.15	129	243340	5003	46437590
Immunodeficiency	99.79	11.15	215	243254	12891	46429702
Neuromyelitis optica spectrum disorder	99.59	11.15	59	243410	769	46441824
Epstein-Barr virus infection	99.21	11.15	148	243321	6636	46435957
Unresponsive to stimuli	99.13	11.15	23	243446	32151	46410442
Dyskinesia	98.98	11.15	16	243453	28909	46413684
Bone marrow failure	98.82	11.15	360	243109	29309	46413284
Swelling face	98.76	11.15	79	243390	52980	46389613
Myocardial infarction	98.65	11.15	227	243242	97301	46345292
Malaise	97.55	11.15	1182	242287	330050	46112543
Asthenia	97.03	11.15	1096	242373	309979	46132614
Agranulocytosis	96.89	11.15	295	243174	21890	46420703
Red blood cell sedimentation rate abnormal	95.00	11.15	216	243253	13433	46429160
Abdominal pain upper	94.35	11.15	413	243056	144892	46297701
Leukopenia	94.18	11.15	645	242824	67698	46374895
Liver function test increased	93.65	11.15	297	243172	22529	46420064
Blood glucose increased	93.63	11.15	144	243325	71869	46370724
Lethargy	92.99	11.15	78	243391	51093	46391500
Discomfort	92.91	11.15	485	242984	46185	46396408
Headache	92.42	11.15	1850	241619	476502	45966091
Hepatitis B reactivation	90.66	11.15	70	243399	1444	46441149
Dysgeusia	90.64	11.15	49	243420	40442	46402151
Therapy non-responder	90.62	11.15	440	243029	40712	46401881
Bronchitis chronic	90.14	11.15	110	243359	4057	46438536
Disorientation	89.72	11.15	40	243429	36878	46405715
Blood immunoglobulin M decreased	89.03	11.15	52	243417	659	46441934
Therapy cessation	88.33	11.15	16	243453	26613	46415980
Paraesthesia	88.18	11.15	315	243154	117122	46325471
Product prescribing error	87.51	11.15	4	243465	20043	46422550
Ulcer	87.23	11.15	243	243226	17149	46425444
Device issue	87.18	11.15	4	243465	19976	46422617
Obliterative bronchiolitis	87.02	11.15	73	243396	1702	46440891
Duodenal ulcer perforation	85.88	11.15	157	243312	8345	46434248
Spinal column injury	85.67	11.15	73	243396	1740	46440853
Therapy partial responder	84.56	11.15	113	243356	4569	46438024
Migraine	84.52	11.15	147	243322	69879	46372714
Haematochezia	84.47	11.15	45	243424	37448	46405145
Physical disability	84.05	11.15	73	243396	1787	46440806
Hypokalaemia	83.39	11.15	212	243257	87812	46354781
Surgical failure	81.31	11.15	55	243414	915	46441678
Coma	80.43	11.15	112	243357	58237	46384356
Chest pain	78.16	11.15	568	242901	175756	46266837
Onychomycosis	77.92	11.15	102	243367	4041	46438552
Sopor	77.57	11.15	7	243462	19821	46422772
Irritability	77.52	11.15	27	243442	28919	46413674
Condition aggravated	76.96	11.15	1745	241724	243307	46199286
Blood pressure diastolic decreased	76.71	11.15	204	243265	14007	46428586
Second primary malignancy	76.10	11.15	129	243340	6455	46436138
Injection site haemorrhage	74.22	11.15	10	243459	20699	46421894
Accidental overdose	73.58	11.15	9	243460	20057	46422536
Pruritus	72.72	11.15	861	242608	241491	46201102
Autoimmune haemolytic anaemia	72.70	11.15	100	243369	4158	46438435
Smooth muscle cell neoplasm	72.68	11.15	42	243427	521	46442072
Lymphoma	72.45	11.15	159	243310	9654	46432939
Flatulence	72.23	11.15	30	243439	28848	46413745
Blood immunoglobulin G decreased	71.94	11.15	67	243402	1801	46440792
Skin ulcer	71.42	11.15	347	243122	32111	46410482
Blood alkaline phosphatase increased	71.20	11.15	61	243408	39548	46403045
Red cell distribution width decreased	71.18	11.15	49	243420	840	46441753
Blood cholesterol increased	71.00	11.15	403	243066	39610	46402983
Deformity	70.77	11.15	132	243337	7125	46435468
Exposure during pregnancy	70.57	11.15	307	243162	107905	46334688
Oxygen saturation decreased	70.29	11.15	608	242861	68556	46374037
Urinary tract infection	69.80	11.15	773	242696	219493	46223100
Fine motor skill dysfunction	69.45	11.15	91	243378	3609	46438984
Blood pressure systolic increased	69.37	11.15	316	243153	28471	46414122
Sedation	69.35	11.15	17	243452	22893	46419700
Red blood cell sedimentation rate	69.07	11.15	64	243405	1709	46440884
Central nervous system lymphoma	68.66	11.15	55	243414	1199	46441394
Seronegative arthritis	68.62	11.15	45	243424	709	46441884
Haemophagocytic lymphohistiocytosis	68.33	11.15	141	243328	8201	46434392
Hypophagia	67.76	11.15	34	243435	29272	46413321
Infusion site reaction	67.27	11.15	63	243406	1706	46440887
Aspergillus infection	66.79	11.15	125	243344	6765	46435828
Depression	66.52	11.15	567	242902	169537	46273056
Injection site rash	66.37	11.15	4	243465	15809	46426784
Restlessness	66.33	11.15	25	243444	25499	46417094
Blood creatine phosphokinase increased	65.87	11.15	31	243438	27693	46414900
Surgery	65.65	11.15	34	243435	28751	46413842
Product substitution issue	65.61	11.15	3	243466	15028	46427565
Cerebral toxoplasmosis	65.27	11.15	43	243426	683	46441910
Vascular access complication	65.25	11.15	48	243421	918	46441675
Haematotoxicity	65.00	11.15	124	243345	6809	46435784
Abnormal behaviour	64.98	11.15	15	243454	21043	46421550
Nightmare	64.56	11.15	6	243463	16592	46426001
Haematemesis	64.26	11.15	35	243434	28771	46413822
Disturbance in attention	63.90	11.15	43	243426	31517	46411076
Blood potassium decreased	63.24	11.15	63	243406	38000	46404593
Pre-existing disease	62.88	11.15	26	243443	143	46442450
Chronic kidney disease	61.96	11.15	73	243396	40798	46401795
Osteonecrosis of jaw	61.81	11.15	53	243416	34349	46408244
Glomerulonephritis	61.70	11.15	57	243412	1516	46441077
Gastric disorder	61.29	11.15	289	243180	26416	46416177
Laryngeal disorder	61.28	11.15	44	243425	809	46441784
Accidental exposure to product	61.22	11.15	17	243452	21064	46421529
Arthrodesis	61.13	11.15	67	243402	2197	46440396
Lymphoma transformation	60.99	11.15	25	243444	134	46442459
Pancytopenia	60.79	11.15	695	242774	84363	46358230
Mean platelet volume decreased	60.29	11.15	56	243413	1500	46441093
Posterior reversible encephalopathy syndrome	60.28	11.15	195	243274	14946	46427647
Acquired haemophilia	60.06	11.15	45	243424	886	46441707
Caesarean section	59.54	11.15	8	243461	16595	46425998
Blood urea increased	59.24	11.15	29	243440	25323	46417270
Injection site bruising	59.18	11.15	59	243410	35577	46407016
Mobility decreased	59.14	11.15	528	242941	60066	46382527
Hepatitis E	58.77	11.15	50	243419	1189	46441404
Therapy responder	58.21	11.15	31	243438	324	46442269
Renal failure	57.81	11.15	351	243118	113243	46329350
Speech disorder	57.67	11.15	62	243407	36105	46406488
Skin exfoliation	57.67	11.15	52	243417	32886	46409707
Varicella zoster virus infection	57.55	11.15	66	243403	2277	46440316
Lymphopenia	57.34	11.15	193	243276	15100	46427493
Interstitial lung disease	57.31	11.15	479	242990	53470	46389123
Dry skin	57.25	11.15	78	243391	40938	46401655
Sensitivity to weather change	57.16	11.15	103	243366	5413	46437180
Anaemia	57.10	11.15	964	242505	254815	46187778
Palpitations	56.91	11.15	279	243190	94980	46347613
Thrombocytopenia	56.50	11.15	951	242518	125630	46316963
Coronary artery disease	55.91	11.15	56	243413	33696	46408897
Vasculitis	55.87	11.15	178	243291	13533	46429060
Withdrawal syndrome	55.79	11.15	13	243456	18121	46424472
Hypotension	55.76	11.15	865	242604	231724	46210869
Mental status changes	55.66	11.15	70	243399	38018	46404575
Pulmonary toxicity	55.64	11.15	93	243376	4600	46437993
Psoriasis	55.61	11.15	216	243253	78388	46364205
Humoral immune defect	55.42	11.15	19	243450	55	46442538
Product administration error	55.09	11.15	17	243452	19664	46422929
Aggression	54.70	11.15	25	243444	22719	46419874
Epistaxis	54.10	11.15	164	243305	64141	46378452
Blood glucose decreased	53.45	11.15	16	243453	18876	46423717
Loss of consciousness	53.23	11.15	338	243131	107900	46334693
Blood bilirubin increased	52.96	11.15	60	243409	34124	46408469
Vertigo	52.72	11.15	121	243348	51927	46390666
Meningoencephalitis viral	52.63	11.15	28	243441	292	46442301
Therapeutic response unexpected	52.63	11.15	9	243460	15607	46426986
Immunoglobulins decreased	52.60	11.15	40	243429	806	46441787
Fluid overload	52.46	11.15	39	243430	27146	46415447
Joint destruction	52.37	11.15	72	243397	2992	46439601
Diabetic ketoacidosis	52.30	11.15	15	243454	18195	46424398
Hypocalcaemia	52.24	11.15	38	243431	26747	46415846
Rectal haemorrhage	52.14	11.15	74	243395	38181	46404412
Neuropathy peripheral	52.14	11.15	270	243199	90623	46351970
Neutropenic sepsis	52.06	11.15	162	243307	12162	46430431
Balance disorder	51.85	11.15	168	243301	64353	46378240
Febrile bone marrow aplasia	51.59	11.15	112	243357	6750	46435843
Palmar-plantar erythrodysaesthesia syndrome	51.54	11.15	21	243448	20430	46422163
Bone swelling	51.11	11.15	46	243423	1182	46441411
Underdose	51.08	11.15	19	243450	19539	46423054
Full blood count decreased	51.00	11.15	26	243443	22185	46420408
Nervousness	51	11.15	44	243425	28431	46414162
Pulmonary hypertension	50.69	11.15	68	243401	35925	46406668
Head injury	50.64	11.15	33	243436	24603	46417990
Dislocation of vertebra	50.39	11.15	47	243422	1266	46441327
Pneumocystis jirovecii infection	50.18	11.15	46	243423	1211	46441382
Hyperlipidaemia	50.15	11.15	17	243452	18522	46424071
Electric shock	50.13	11.15	40	243429	867	46441726
Wrist deformity	49.91	11.15	50	243419	1474	46441119
Psoriatic arthropathy	49.89	11.15	343	243126	36036	46406557
Soft tissue disorder	49.69	11.15	83	243386	4103	46438490
Hyperglycaemia	49.65	11.15	66	243403	35005	46407588
Disease progression	49.54	11.15	709	242760	90591	46352002
Product storage error	49.44	11.15	3	243466	11789	46430804
Hypoaesthesia	49.28	11.15	390	243079	118479	46324114
Pulmonary oedema	49.23	11.15	122	243347	50983	46391610
Mean cell volume decreased	48.91	11.15	62	243407	2378	46440215
Heart rate decreased	48.90	11.15	308	243161	31415	46411178
Injection site warmth	48.53	11.15	7	243462	13765	46428828
Blood pressure increased	48.51	11.15	929	242540	125737	46316856
Peptic ulcer haemorrhage	48.30	11.15	41	243428	972	46441621
Urinary retention	48.24	11.15	39	243430	26022	46416571
Tenosynovitis	48.00	11.15	115	243354	7400	46435193
Swollen tongue	47.85	11.15	49	243420	29183	46413410
Injection site mass	47.85	11.15	10	243459	15030	46427563
Hypercalcaemia	47.74	11.15	227	243242	20819	46421774
Blood iron abnormal	47.56	11.15	70	243399	3100	46439493
B-cell lymphoma refractory	47.35	11.15	18	243451	76	46442517
Generalised tonic-clonic seizure	47.26	11.15	43	243426	27079	46415514
Wheezing	47.20	11.15	133	243336	53253	46389340
Chronic obstructive pulmonary disease	47.05	11.15	149	243320	57484	46385109
Back pain	47.05	11.15	791	242678	209248	46233345
Road traffic accident	47.00	11.15	33	243436	23658	46418935
Orthostatic hypotension	46.78	11.15	36	243433	24622	46417971
Cytopenia	46.56	11.15	116	243353	7652	46434941
Angioedema	46.19	11.15	84	243385	39258	46403335
Mental disorder	46.15	11.15	30	243439	22395	46420198
Adjustment disorder with depressed mood	46.06	11.15	42	243427	1098	46441495
Hallucination, visual	45.62	11.15	18	243451	17855	46424738
Tachycardia	45.52	11.15	318	243151	99304	46343289
Foetal exposure during pregnancy	45.46	11.15	56	243413	30691	46411902
Pulmonary arterial hypertension	45.31	11.15	41	243428	25887	46416706
Fluid retention	45.26	11.15	127	243342	50919	46391674
Cardiac disorder	45.20	11.15	101	243368	43757	46398836
Product label confusion	45.03	11.15	26	243443	322	46442271
Depressed mood	44.87	11.15	65	243404	33254	46409339
Injection site urticaria	44.79	11.15	5	243464	11962	46430631
Panic attack	44.57	11.15	25	243444	20217	46422376
West Nile viral infection	44.54	11.15	27	243442	368	46442225
Device malfunction	44.43	11.15	8	243461	13366	46429227
Dysarthria	44.08	11.15	80	243389	37418	46405175
Abdominal pain lower	44.05	11.15	28	243441	21153	46421440
Extrapyramidal disorder	44.02	11.15	4	243465	11264	46431329
Musculoskeletal pain	43.97	11.15	559	242910	69569	46373024
Dystonia	43.97	11.15	4	243465	11253	46431340
Ankle operation	43.84	11.15	42	243427	1171	46441422
Chromaturia	43.82	11.15	12	243457	15007	46427586
Mantle cell lymphoma	43.64	11.15	31	243438	560	46442033
Metastases to liver	43.39	11.15	24	243445	19561	46423032
Peripheral swelling	43.29	11.15	1105	242364	156966	46285627
Lung disorder	43.11	11.15	379	243090	42925	46399668
Musculoskeletal disorder	43.08	11.15	178	243291	15367	46427226
Blood calcium decreased	43.04	11.15	14	243455	15659	46426934
Abortion spontaneous	42.98	11.15	103	243366	43543	46399050
Drug reaction with eosinophilia and systemic symptoms	42.45	11.15	55	243414	29493	46413100
Device dislocation	42.43	11.15	31	243438	21771	46420822
Blood sodium decreased	42.14	11.15	31	243438	21695	46420898
Hepatic function abnormal	41.76	11.15	72	243397	34349	46408244
Drug level increased	41.73	11.15	22	243447	18419	46424174
Nodule	41.16	11.15	176	243293	15429	46427164
Delusion	41.07	11.15	5	243464	11183	46431410
Drug-induced liver injury	40.99	11.15	43	243426	25325	46417268
Cardiomegaly	40.84	11.15	20	243449	17462	46425131
Metastases to bone	40.82	11.15	20	243449	17456	46425137
Drug eruption	40.62	11.15	219	243250	21110	46421483
Temperature regulation disorder	40.39	11.15	67	243402	3293	46439300
Hypersomnia	40.32	11.15	15	243454	15424	46427169
Cholecystitis chronic	40.29	11.15	4	243465	10495	46432098
Nail disorder	40.26	11.15	111	243358	7785	46434808
Neck deformity	40.20	11.15	49	243420	1805	46440788
Cellulitis	40.19	11.15	209	243260	70079	46372514
Eye pain	40.15	11.15	52	243417	27888	46414705
Jaundice	40.11	11.15	55	243414	28790	46413803
Mucosal inflammation	39.77	11.15	343	243126	38633	46403960
Therapy interrupted	39.18	11.15	5	243464	10786	46431807
Urinary incontinence	39.07	11.15	55	243414	28475	46414118
Haemoglobin decreased	39.04	11.15	457	243012	128492	46314101
Frequent bowel movements	38.97	11.15	9	243460	12623	46429970
Monocyte count increased	38.46	11.15	83	243386	4981	46437612
Right ventricular failure	38.22	11.15	18	243451	16075	46426518
Ankle arthroplasty	38.06	11.15	29	243440	586	46442007
Transfusion	37.81	11.15	11	243458	13220	46429373
Mean cell haemoglobin decreased	37.63	11.15	60	243409	2852	46439741
Acute myocardial infarction	37.62	11.15	68	243401	31856	46410737
Blood potassium increased	37.29	11.15	21	243448	16946	46425647
Complication associated with device	37.09	11.15	17	243452	15424	46427169
Pancreatitis	36.88	11.15	111	243358	43516	46399077
Blood pressure decreased	36.73	11.15	163	243306	56996	46385597
Blood count abnormal	36.68	11.15	24	243445	17854	46424739
Sinus bradycardia	36.65	11.15	13	243456	13769	46428824
Mesenteritis	36.34	11.15	17	243452	131	46442462
Mantle cell lymphoma recurrent	35.98	11.15	16	243453	108	46442485
Abdominal distension	35.57	11.15	230	243239	73121	46369472
Osteoarthritis	35.38	11.15	486	242983	61539	46381054
Finger deformity	35.15	11.15	81	243388	5081	46437512
Joint range of motion decreased	34.94	11.15	164	243305	14960	46427633
Transient ischaemic attack	34.65	11.15	82	243387	34821	46407772
Unevaluable event	34.53	11.15	124	243345	46051	46396542
Lupus nephritis	34.28	11.15	50	243419	2196	46440397
Fear	34.15	11.15	21	243448	16151	46426442
Back injury	34.01	11.15	96	243373	6825	46435768
Haematoma	34.00	11.15	72	243397	31800	46410793
Wrist surgery	33.75	11.15	30	243439	758	46441835
Lip swelling	33.75	11.15	50	243419	25345	46417248
Eye swelling	33.70	11.15	33	243436	20070	46422523
Gamma-glutamyltransferase increased	33.61	11.15	72	243397	31668	46410925
Anger	33.60	11.15	10	243459	11842	46430751
Femur fracture	33.57	11.15	91	243378	36906	46405687
Epstein-Barr virus associated lymphoproliferative disorder	33.55	11.15	40	243429	1439	46441154
Neck mass	33.50	11.15	61	243408	3232	46439361
Pallor	33.40	11.15	43	243426	23123	46419470
Swollen joint count increased	33.17	11.15	51	243418	2349	46440244
Visual acuity reduced	32.98	11.15	40	243429	22073	46420520
Hip fracture	32.71	11.15	55	243414	26501	46416092
Respiratory depression	32.50	11.15	10	243459	11590	46431003
Muscular weakness	32.44	11.15	314	243155	91530	46351063
Ocular hyperaemia	32.31	11.15	33	243436	19677	46422916
Syncope	32.27	11.15	370	243099	104433	46338160
Acute myeloid leukaemia	32.10	11.15	165	243304	15613	46426980
Obstructive airways disorder	31.86	11.15	15	243454	13397	46429196
Haemodialysis	31.76	11.15	5	243464	9212	46433381
Amnesia	31.67	11.15	111	243358	41520	46401073
Cholelithiasis	31.57	11.15	100	243369	38581	46404012
Coagulopathy	31.44	11.15	30	243439	18469	46424124
Breast cancer metastatic	31.42	11.15	16	243453	13662	46428931
Malignant neoplasm progression	31.27	11.15	204	243265	64722	46377871
Incorrect product administration duration	31.23	11.15	6	243463	9571	46433022
Hypomagnesaemia	31.23	11.15	42	243427	22168	46420425
Faeces discoloured	31.22	11.15	25	243444	16762	46425831
Injection site induration	31.21	11.15	3	243466	8076	46434517
Myoclonus	31.20	11.15	18	243451	14334	46428259
Lipase increased	31.20	11.15	4	243465	8599	46433994
Renal injury	31.07	11.15	6	243463	9535	46433058
Mania	31.02	11.15	9	243460	10837	46431756
Incorrect route of product administration	30.97	11.15	24	243445	16359	46426234
Adenovirus infection	30.81	11.15	54	243415	2776	46439817
Ventricular tachycardia	30.65	11.15	26	243443	16941	46425652
Contusion	30.52	11.15	300	243169	87187	46355406
Intestinal sepsis	30.23	11.15	18	243451	237	46442356
Ventricular extrasystoles	30.17	11.15	10	243459	11053	46431540
Pollakiuria	30.11	11.15	50	243419	24211	46418382
Thyroid neoplasm	30.03	11.15	62	243407	3607	46438986
Cytomegalovirus colitis	30.00	11.15	41	243428	1694	46440899
Oedema	29.70	11.15	216	243253	66855	46375738
Psychotic disorder	29.61	11.15	45	243424	22576	46420017
Product complaint	29.57	11.15	13	243456	12088	46430505
Gastrosplenic fistula	29.40	11.15	11	243458	44	46442549
Sinus tachycardia	29.38	11.15	42	243427	21607	46420986
Bronchiectasis	29.31	11.15	111	243358	9205	46433388
Gene mutation	29.23	11.15	32	243437	1048	46441545
Influenza like illness	29.21	11.15	178	243291	57392	46385201
Stevens-Johnson syndrome	28.93	11.15	48	243421	23249	46419344
Dermatitis contact	28.93	11.15	4	243465	8119	46434474
Rhinorrhoea	28.80	11.15	139	243330	47526	46395067
Episcleritis	28.68	11.15	27	243442	736	46441857
Nerve injury	28.67	11.15	97	243372	7608	46434985
Acute hepatitis B	28.62	11.15	19	243450	306	46442287
Hypoxia	28.59	11.15	156	243313	51682	46390911
Oesophagitis	28.45	11.15	18	243451	13633	46428960
Affect lability	28.44	11.15	4	243465	8016	46434577
Device difficult to use	28.36	11.15	4	243465	8000	46434593
X-ray abnormal	28.24	11.15	33	243436	1162	46441431
Proteinuria	28.23	11.15	165	243304	16388	46426205
Injection site hypersensitivity	28.13	11.15	37	243432	1473	46441120
Poor quality sleep	28.01	11.15	23	243446	15230	46427363
Bronchopulmonary aspergillosis	27.57	11.15	94	243375	7402	46435191
Tubulointerstitial nephritis	27.53	11.15	22	243447	14766	46427827
Metastases to central nervous system	27.51	11.15	12	243457	11209	46431384
Hysterectomy	27.43	11.15	4	243465	7802	46434791
Acidosis	27.31	11.15	12	243457	11162	46431431
Accident	27.27	11.15	73	243396	5031	46437562
Cartilage atrophy	27.20	11.15	15	243454	169	46442424
Neck pain	27.06	11.15	422	243047	54884	46387709
Ageusia	26.99	11.15	13	243456	11459	46431134
Injury	26.83	11.15	128	243341	43899	46398694
Extranodal marginal zone B-cell lymphoma (MALT type)	26.80	11.15	21	243448	443	46442150
Cystitis haemorrhagic	26.78	11.15	58	243411	3489	46439104
Pancreatitis acute	26.68	11.15	56	243413	24816	46417777
Rheumatic disorder	26.61	11.15	35	243434	1393	46441200
Onychomadesis	26.58	11.15	51	243418	2812	46439781
Larynx irritation	26.46	11.15	13	243456	113	46442480
Altered state of consciousness	26.39	11.15	51	243418	23297	46419296
Hypokinesia	26.38	11.15	13	243456	11309	46431284
Dyspnoea exertional	26.30	11.15	154	243315	50135	46392458
Melaena	26.20	11.15	67	243402	27705	46414888
Cytomegalovirus viraemia	25.93	11.15	66	243403	4412	46438181
Seasonal allergy	25.89	11.15	19	243450	13315	46429278
Nasal congestion	25.88	11.15	146	243323	47967	46394626
Delirium	25.87	11.15	103	243366	37125	46405468
Viral upper respiratory tract infection	25.81	11.15	88	243381	6930	46435663
Intervertebral discitis	25.78	11.15	47	243422	2492	46440101
Blood pressure diastolic increased	25.67	11.15	79	243390	5895	46436698
Prothrombin time prolonged	25.61	11.15	9	243460	9587	46433006
Vulvovaginal ulceration	25.57	11.15	6	243463	0	46442593
Cytokine release syndrome	25.55	11.15	81	243388	6142	46436451
Rash papular	25.54	11.15	18	243451	12880	46429713
Red blood cell count decreased	25.47	11.15	86	243383	32537	46410056
Torsade de pointes	25.36	11.15	16	243453	12138	46430455
Anuria	25.33	11.15	14	243455	11417	46431176
Lower respiratory tract infection	25.32	11.15	416	243053	54673	46387920
Platelet count abnormal	25.27	11.15	49	243420	2723	46439870
Osteonecrosis	25.15	11.15	61	243408	25683	46416910
Septic shock	25.09	11.15	433	243036	57460	46385133
Post procedural complication	25.03	11.15	27	243442	15702	46426891
Erythropoiesis abnormal	24.90	11.15	16	243453	243	46442350
Pulmonary mass	24.85	11.15	169	243300	17688	46424905
Pelvic pain	24.59	11.15	15	243454	11587	46431006
Diverticulum	24.44	11.15	14	243455	11192	46431401
Impaired gastric emptying	24.43	11.15	95	243374	7977	46434616
Rheumatic fever	24.40	11.15	49	243420	2794	46439799
Cervix disorder	24.40	11.15	20	243449	451	46442142
Haematocrit decreased	24.36	11.15	97	243372	34960	46407633
Cytomegalovirus infection reactivation	24.28	11.15	34	243435	1438	46441155
Dysstasia	24.25	11.15	34	243435	17634	46424959
Blood calcium increased	24.23	11.15	5	243464	7582	46435011
Pneumonia aspiration	24.22	11.15	84	243385	31521	46411072
Cryoglobulinaemia	24.13	11.15	18	243451	352	46442241
Leukoerythroblastosis	23.97	11.15	15	243454	217	46442376
Genital haemorrhage	23.94	11.15	3	243466	6563	46436030
Parkinsonism	23.86	11.15	6	243463	7942	46434651
Hyperhidrosis	23.85	11.15	325	243144	88983	46353610
Overlap syndrome	23.82	11.15	22	243447	585	46442008
Meningitis enteroviral	23.67	11.15	7	243462	10	46442583
Encephalitis	23.64	11.15	89	243380	7359	46435234
Eating disorder	23.49	11.15	25	243444	14629	46427964
Bunion operation	23.47	11.15	25	243444	793	46441800
Blood lactate dehydrogenase abnormal	23.46	11.15	16	243453	270	46442323
Pneumonia cytomegaloviral	23.45	11.15	39	243430	1921	46440672
Limb operation	23.42	11.15	53	243416	3285	46439308
Dizziness postural	23.37	11.15	3	243466	6443	46436150
Human herpesvirus 6 infection	23.33	11.15	44	243425	2395	46440198
Mydriasis	23.28	11.15	13	243456	10540	46432053
Thinking abnormal	23.27	11.15	11	243458	9803	46432790
Genitourinary tract infection	23.23	11.15	13	243456	151	46442442
Vaginal haemorrhage	23.21	11.15	63	243406	25541	46417052
Toxic epidermal necrolysis	23.20	11.15	51	243418	22227	46420366
Precancerous cells present	23.14	11.15	30	243439	1177	46441416
Glycosylated haemoglobin increased	23.14	11.15	14	243455	10862	46431731
Dialysis	22.99	11.15	12	243457	10104	46432489
Nephrotic syndrome	22.96	11.15	67	243402	4854	46437739
Campylobacter gastroenteritis	22.96	11.15	18	243451	380	46442213
Amyotrophic lateral sclerosis	22.89	11.15	28	243441	1035	46441558
Device breakage	22.77	11.15	11	243458	9681	46432912
Oral pruritus	22.48	11.15	33	243436	1458	46441135
Anti-neutrophil cytoplasmic antibody positive vasculitis	22.48	11.15	38	243431	1897	46440696
Skin discolouration	22.34	11.15	91	243378	32589	46410004
Infection reactivation	22.24	11.15	24	243445	773	46441820
Mood altered	22.21	11.15	21	243448	12986	46429607
Citrobacter bacteraemia	22.21	11.15	7	243462	14	46442579
Upper gastrointestinal haemorrhage	22.20	11.15	33	243436	16705	46425888
Chest discomfort	22.17	11.15	334	243135	89935	46352658
Angina unstable	22.08	11.15	6	243463	7542	46435051
Dysuria	21.99	11.15	73	243396	27760	46414833
Anovulatory cycle	21.93	11.15	12	243457	133	46442460
Electrolyte imbalance	21.85	11.15	35	243434	17191	46425402
Flank pain	21.83	11.15	18	243451	11895	46430698
Heart rate abnormal	21.81	11.15	52	243417	3335	46439258
Chronic lymphocytic leukaemia transformation	21.78	11.15	8	243461	30	46442563
5q minus syndrome	21.71	11.15	13	243456	173	46442420
Bone density abnormal	21.67	11.15	49	243420	3035	46439558
Burning sensation	21.66	11.15	139	243330	44272	46398321
Hypothermia	21.60	11.15	19	243450	12164	46430429
Infusion site pain	21.51	11.15	13	243456	10094	46432499
Transplant rejection	21.40	11.15	103	243366	9493	46433100
Blood triglycerides increased	21.35	11.15	18	243451	11765	46430828
Muscle spasticity	21.32	11.15	17	243452	11423	46431170
Urine output decreased	21.31	11.15	16	243453	11081	46431512
Toxic neuropathy	21.28	11.15	17	243452	369	46442224
Retching	21.24	11.15	22	243447	13035	46429558
Infected seroma	21.12	11.15	9	243460	54	46442539
Wheelchair user	21.09	11.15	57	243412	3951	46438642
Cestode infection	21.07	11.15	15	243454	272	46442321
Cardiogenic shock	21.05	11.15	33	243436	16351	46426242
Ocular lymphoma	20.99	11.15	9	243460	55	46442538
Hypoglobulinaemia	20.97	11.15	6	243463	7	46442586
Muscle rigidity	20.94	11.15	13	243456	9948	46432645
Visual impairment	20.69	11.15	235	243234	66454	46376139
Diffuse alveolar damage	20.65	11.15	23	243446	768	46441825
Anaphylactic shock	20.63	11.15	47	243422	20227	46422366
Duodenal ulcer	20.63	11.15	6	243463	7212	46435381
Clear cell renal cell carcinoma	20.60	11.15	26	243443	993	46441600
Atrial septal defect	20.58	11.15	4	243465	6328	46436265
CD4 lymphocytes decreased	20.57	11.15	33	243436	1577	46441016
Procedural pain	20.56	11.15	23	243446	13156	46429437
Conjunctival scar	20.49	11.15	7	243462	20	46442573
Renal disorder	20.39	11.15	71	243398	26615	46415978
Deep vein thrombosis	20.34	11.15	293	243176	79480	46363113
Creutzfeldt-Jakob disease	20.33	11.15	9	243460	60	46442533
Nocturia	20.25	11.15	6	243463	7126	46435467
Treatment noncompliance	20.19	11.15	83	243386	29648	46412945
Premature baby	20.09	11.15	40	243429	18072	46424521
Peritonitis bacterial	20.06	11.15	10	243459	8643	46433950
Joint dislocation	20.06	11.15	113	243356	11073	46431520
Multiple system atrophy	19.98	11.15	13	243456	202	46442391
Cardiomyopathy	19.97	11.15	148	243321	15925	46426668
Malignant transformation	19.82	11.15	15	243454	300	46442293
Food allergy	19.70	11.15	80	243389	6853	46435740
Blood lactic acid increased	19.65	11.15	3	243466	5654	46436939
Retinal deposits	19.62	11.15	9	243460	66	46442527
Cardiac failure	19.56	11.15	296	243173	79652	46362941
Wrong product administered	19.52	11.15	3	243466	5627	46436966
Refractory anaemia with an excess of blasts	19.51	11.15	17	243452	418	46442175
Inappropriate antidiuretic hormone secretion	19.49	11.15	27	243442	14075	46428518
Abortion induced	19.43	11.15	15	243454	10245	46432348
Sarcoidosis	19.24	11.15	65	243404	5094	46437499
Blood immunoglobulin A decreased	19.24	11.15	15	243454	314	46442279
B-cell small lymphocytic lymphoma	19.11	11.15	7	243462	26	46442567
Low density lipoprotein increased	19.06	11.15	4	243465	5996	46436597
B-lymphocyte count abnormal	19.06	11.15	8	243461	46	46442547
Circulatory collapse	19.01	11.15	54	243415	21570	46421023
Maternal drugs affecting foetus	19.00	11.15	3	243466	5515	46437078
Mitral valve incompetence	18.95	11.15	44	243425	18808	46423785
Gestational diabetes	18.87	11.15	7	243462	7212	46435381
Nail bed inflammation	18.82	11.15	16	243453	380	46442213
Breast pain	18.81	11.15	8	243461	7586	46435007
Opsoclonus myoclonus	18.79	11.15	11	243458	140	46442453
Disseminated varicella zoster virus infection	18.74	11.15	21	243448	706	46441887
Cognitive disorder	18.73	11.15	114	243355	36769	46405824
T-lymphocyte count increased	18.66	11.15	10	243459	106	46442487
Pneumonia viral	18.47	11.15	76	243393	6548	46436045
Concomitant disease aggravated	18.44	11.15	9	243460	7873	46434720
Immunodeficiency common variable	18.42	11.15	10	243459	109	46442484
Sleep apnoea syndrome	18.39	11.15	57	243412	22144	46420449
Tumour flare	18.37	11.15	14	243455	283	46442310
Lymphadenectomy	18.33	11.15	23	243446	873	46441720
Tricuspid valve incompetence	18.23	11.15	27	243442	13690	46428903
Needle issue	18.17	11.15	4	243465	5800	46436793
CD4 lymphocytes increased	18.14	11.15	11	243458	150	46442443
Gastritis	18.12	11.15	105	243364	34273	46408320
Malignant melanoma	18.10	11.15	103	243366	10131	46432462
Incorrect dosage administered	18.06	11.15	32	243437	1659	46440934
Atelectasis	17.98	11.15	45	243424	18745	46423848
Hospice care	17.96	11.15	3	243466	5292	46437301
Atrioventricular block first degree	17.94	11.15	5	243464	6181	46436412
Nasopharyngitis	17.86	11.15	978	242491	153020	46289573
Myelitis	17.79	11.15	26	243443	1144	46441449
Leukaemic lymphoma	17.77	11.15	9	243460	84	46442509
Systemic candida	17.71	11.15	42	243427	2685	46439908
Allergic oedema	17.65	11.15	21	243448	754	46441839
Cryptococcosis	17.64	11.15	22	243447	830	46441763
Glomerular filtration rate decreased	17.60	11.15	21	243448	11673	46430920
Ascites	17.58	11.15	115	243354	36469	46406124
Eructation	17.57	11.15	8	243461	7287	46435306
Skin irritation	17.54	11.15	8	243461	7279	46435314
Face oedema	17.46	11.15	47	243422	19106	46423487
Feeling jittery	17.40	11.15	19	243450	10989	46431604
Selective IgG subclass deficiency	17.40	11.15	5	243464	6	46442587
Central nervous system vasculitis	17.38	11.15	23	243446	921	46441672
Non-Hodgkin's lymphoma	17.37	11.15	30	243439	1524	46441069
Haemoptysis	17.24	11.15	74	243395	26115	46416478
Haemorrhoids	17.17	11.15	46	243423	18731	46423862
Gastric stenosis	17.17	11.15	8	243461	61	46442532
JC polyomavirus test positive	17.13	11.15	23	243446	934	46441659
Cyanosis	17.10	11.15	36	243433	15935	46426658
Pulseless electrical activity	17.05	11.15	8	243461	7159	46435434
Myeloid leukaemia	17.03	11.15	14	243455	317	46442276
Lip pruritus	17.03	11.15	17	243452	499	46442094
Acute respiratory failure	17.01	11.15	86	243383	29052	46413541
Aplasia	16.99	11.15	49	243420	3527	46439066
Polyomavirus-associated nephropathy	16.96	11.15	29	243440	1461	46441132
Lower limb fracture	16.88	11.15	24	243445	12374	46430219
Amenorrhoea	16.85	11.15	13	243456	8882	46433711
Hypovolaemia	16.84	11.15	16	243453	9872	46432721
Enterococcal bacteraemia	16.82	11.15	26	243443	1203	46441390
Mucocutaneous leishmaniasis	16.81	11.15	14	243455	323	46442270
COVID-19	16.67	11.15	159	243310	18416	46424177
Arteriosclerosis coronary artery	16.66	11.15	11	243458	8145	46434448
Iron deficiency anaemia	16.62	11.15	41	243428	17165	46425428
Amylase increased	16.62	11.15	4	243465	5455	46437138
Chronic hepatitis	16.62	11.15	21	243448	803	46441790
Tooth loss	16.58	11.15	7	243462	6666	46435927
Babesiosis	16.57	11.15	7	243462	41	46442552
Dementia	16.54	11.15	33	243436	14897	46427696
Hyperbilirubinaemia	16.52	11.15	18	243451	10420	46432173
Eye irritation	16.52	11.15	39	243430	16575	46426018
Subclavian artery occlusion	16.44	11.15	6	243463	22	46442571
Concussion	16.38	11.15	8	243461	6995	46435598
Dermatomyositis	16.36	11.15	34	243435	1987	46440606
Bradyphrenia	16.36	11.15	6	243463	6224	46436369
Complication of device insertion	16.33	11.15	3	243466	4941	46437652
Primary immunodeficiency syndrome	16.29	11.15	7	243462	43	46442550
Arteriosclerosis	16.29	11.15	16	243453	9717	46432876
Ganglioneuroma	16.26	11.15	10	243459	140	46442453
Groin pain	16.24	11.15	14	243455	9051	46433542
Follicle centre lymphoma, follicular grade I, II, III stage IV	16.21	11.15	5	243464	9	46442584
Choking	16.18	11.15	12	243457	8364	46434229
Nail pigmentation	16.16	11.15	11	243458	185	46442408
Musculoskeletal chest pain	16.08	11.15	45	243424	18061	46424532
Infusion site erythema	16.03	11.15	10	243459	7632	46434961
Neck surgery	15.98	11.15	28	243441	1439	46441154
Apathy	15.96	11.15	9	243460	7259	46435334
Oral herpes	15.95	11.15	163	243306	19227	46423366
Lymphoproliferative disorder	15.92	11.15	40	243429	2652	46439941
Combined immunodeficiency	15.90	11.15	9	243460	107	46442486
Localised infection	15.89	11.15	192	243277	23609	46418984
Infusion site swelling	15.81	11.15	5	243464	5694	46436899
Pulmonary embolism	15.80	11.15	438	243031	108147	46334446
Muscle strain	15.75	11.15	8	243461	6841	46435752
Limb mass	15.75	11.15	38	243431	2456	46440137
Blood creatinine increased	15.71	11.15	292	243177	76111	46366482
COVID-19 pneumonia	15.68	11.15	45	243424	3230	46439363
Feeding disorder	15.67	11.15	18	243451	10176	46432417
Epilepsy	15.67	11.15	67	243402	23671	46418922
Parotid gland enlargement	15.64	11.15	20	243449	774	46441819
Salivary hypersecretion	15.63	11.15	7	243462	6438	46436155
ADAMTS13 activity decreased	15.59	11.15	8	243461	77	46442516
Nephrogenic systemic fibrosis	15.54	11.15	3	243466	4769	46437824
Middle insomnia	15.51	11.15	16	243453	9499	46433094
Sensory disturbance	15.49	11.15	25	243444	12242	46430351
BK virus infection	15.48	11.15	41	243428	2808	46439785
Colitis ischaemic	15.46	11.15	18	243451	10114	46432479
Hypernatraemia	15.45	11.15	7	243462	6394	46436199
Herpes zoster infection neurological	15.41	11.15	8	243461	79	46442514
Hypercholesterolaemia	15.38	11.15	108	243361	11422	46431171
Mucocutaneous ulceration	15.33	11.15	10	243459	156	46442437
Acute myelomonocytic leukaemia	15.33	11.15	11	243458	202	46442391
Quadrantanopia	15.31	11.15	6	243463	28	46442565
Listeria sepsis	15.30	11.15	17	243452	566	46442027
Acute biphenotypic leukaemia	15.29	11.15	7	243462	51	46442542
Myelosuppression	15.28	11.15	80	243389	7623	46434970
Epstein-Barr virus infection reactivation	15.28	11.15	12	243457	254	46442339
Cholesteatoma	15.28	11.15	9	243460	116	46442477
Escherichia bacteraemia	15.27	11.15	40	243429	2721	46439872
Small intestinal obstruction	15.26	11.15	39	243430	16133	46426460
Bladder disorder	15.21	11.15	9	243460	7069	46435524
Device failure	15.21	11.15	6	243463	5953	46436640
Intestinal obstruction	15.20	11.15	77	243392	25998	46416595
Mycobacterium chelonae infection	15.14	11.15	15	243454	436	46442157
Faecaloma	15.11	11.15	11	243458	7741	46434852
Pain of skin	15.07	11.15	11	243458	7731	46434862
Capillaritis	15.07	11.15	8	243461	83	46442510
Subdural haematoma	15.03	11.15	28	243441	12969	46429624
Pneumonia	14.99	11.15	2209	241260	374111	46068482
Premenstrual syndrome	14.94	11.15	18	243451	655	46441938
Rash macular	14.88	11.15	51	243418	19209	46423384
Compression fracture	14.86	11.15	7	243462	6250	46436343
Microangiopathic haemolytic anaemia	14.84	11.15	15	243454	447	46442146
Gingivitis ulcerative	14.80	11.15	10	243459	166	46442427
Hepatitis B surface antigen positive	14.74	11.15	7	243462	56	46442537
Stem cell transplant	14.64	11.15	30	243439	1736	46440857
Germ cell cancer	14.53	11.15	7	243462	58	46442535
Haemophilus infection	14.51	11.15	21	243448	916	46441677
Juvenile idiopathic arthritis	14.49	11.15	51	243418	4081	46438512
Drug ineffective for unapproved indication	14.48	11.15	140	243329	16273	46426320
Smear cervix abnormal	14.48	11.15	37	243432	2479	46440114
Gout	14.47	11.15	23	243446	11333	46431260
Abnormal loss of weight	14.47	11.15	4	243465	4971	46437622
Illness	14.43	11.15	26	243443	12198	46430395
Respiratory acidosis	14.41	11.15	7	243462	6141	46436452
Tongue disorder	14.39	11.15	75	243394	7135	46435458
Fear of injection	14.38	11.15	51	243418	4096	46438497
Guillain-Barre syndrome	14.34	11.15	44	243425	3278	46439315
Eosinophil count increased	14.27	11.15	12	243457	7854	46434739
Peripheral sensorimotor neuropathy	14.26	11.15	24	243445	1194	46441399
Candida infection	14.24	11.15	178	243291	22062	46420531
Joint prosthesis user	14.22	11.15	6	243463	35	46442558
Application site erythema	14.15	11.15	4	243465	4900	46437693
Non-cardiac chest pain	14.13	11.15	7	243462	6071	46436522
Head discomfort	14.13	11.15	20	243449	10331	46432262
Steroid diabetes	14.10	11.15	17	243452	619	46441974
Micturition urgency	14.09	11.15	12	243457	7805	46434788
Abdominal tenderness	14.04	11.15	10	243459	7118	46435475
Pericardial effusion	14.01	11.15	77	243392	25466	46417127
Extrasystoles	14	11.15	4	243465	4865	46437728
Oliguria	13.98	11.15	15	243454	8744	46433849
Immune thrombocytopenia	13.96	11.15	82	243387	8159	46434434
Bundle branch block left	13.95	11.15	8	243461	6391	46436202
Traumatic lung injury	13.93	11.15	26	243443	1404	46441189
Osteoporosis	13.91	11.15	293	243176	40315	46402278
Inflammatory marker increased	13.86	11.15	61	243408	5414	46437179
Primary mediastinal large B-cell lymphoma recurrent	13.85	11.15	7	243462	65	46442528
Oropharyngeal cancer	13.81	11.15	6	243463	38	46442555
Ischaemic stroke	13.81	11.15	43	243426	16679	46425914
Affective disorder	13.76	11.15	4	243465	4811	46437782
Rheumatoid factor	13.76	11.15	7	243462	66	46442527
Hepatic necrosis	13.71	11.15	6	243463	5595	46436998
Major depression	13.70	11.15	9	243460	6681	46435912
Feeling hot	13.67	11.15	129	243340	37799	46404794
Pyoderma gangrenosum	13.66	11.15	38	243431	2679	46439914
Lacrimation increased	13.66	11.15	40	243429	15821	46426772
Parapsoriasis	13.66	11.15	8	243461	102	46442491
Cold type haemolytic anaemia	13.65	11.15	10	243459	190	46442403
Tooth extraction	13.61	11.15	20	243449	10173	46432420
B-lymphocyte abnormalities	13.56	11.15	5	243464	19	46442574
Hepatitis C RNULL increased	13.55	11.15	9	243460	145	46442448
Knee operation	13.55	11.15	4	243465	4762	46437831
Bacteraemia	13.54	11.15	123	243346	14056	46428537
Refractory cytopenia with unilineage dysplasia	13.52	11.15	16	243453	571	46442022
Diffuse large B-cell lymphoma stage III	13.43	11.15	6	243463	41	46442552
Transient hypogammaglobulinaemia of infancy	13.43	11.15	6	243463	41	46442552
Myocardial ischaemia	13.43	11.15	29	243440	12720	46429873
Pleocytosis	13.42	11.15	15	243454	503	46442090
Premature labour	13.37	11.15	24	243445	11275	46431318
Drug resistance	13.35	11.15	144	243325	17224	46425369
Pulmonary sepsis	13.30	11.15	25	243444	1357	46441236
Magnesium deficiency	13.30	11.15	14	243455	438	46442155
Lymphadenopathy	13.28	11.15	247	243222	33241	46409352
Meningitis cryptococcal	13.27	11.15	23	243446	1172	46441421
Hypotonia	13.23	11.15	14	243455	8215	46434378
Dry mouth	13.22	11.15	204	243265	54722	46387871
Cataract	13.15	11.15	320	243149	45095	46397498
Myelopathy	13.13	11.15	36	243433	2516	46440077
Type 2 diabetes mellitus	13.12	11.15	160	243309	19715	46422878
Osteopenia	13.05	11.15	45	243424	16916	46425677
Intracranial pressure increased	13.03	11.15	3	243466	4217	46438376
Vascular compression	13.01	11.15	8	243461	112	46442481
Chills	12.99	11.15	619	242850	95413	46347180
Central nervous system enteroviral infection	12.99	11.15	5	243464	22	46442571
Nephritic syndrome	12.99	11.15	9	243460	156	46442437
Pneumatosis intestinalis	12.94	11.15	31	243438	1994	46440599
Jaundice cholestatic	12.94	11.15	5	243464	5024	46437569
Subarachnoid haemorrhage	12.92	11.15	24	243445	11129	46431464
Hot flush	12.86	11.15	155	243314	43362	46399231
Atypical femur fracture	12.81	11.15	5	243464	4992	46437601
Tinnitus	12.79	11.15	88	243381	27585	46415008
Encephalitis eastern equine	12.78	11.15	3	243466	0	46442593
SARS-CoV-2 antibody test negative	12.78	11.15	3	243466	0	46442593
Acute flaccid myelitis	12.78	11.15	3	243466	0	46442593
Encephalitis enteroviral	12.78	11.15	3	243466	0	46442593
Chronic lymphocytic leukaemia refractory	12.74	11.15	6	243463	47	46442546
Device leakage	12.74	11.15	6	243463	5359	46437234
Photosensitivity reaction	12.74	11.15	30	243439	12762	46429831
Exercise tolerance decreased	12.73	11.15	4	243465	4573	46438020
Encephalitis viral	12.71	11.15	27	243442	1603	46440990
Sinus disorder	12.70	11.15	44	243425	16519	46426074
Steatohepatitis	12.70	11.15	14	243455	462	46442131
Splenic marginal zone lymphoma recurrent	12.69	11.15	4	243465	8	46442585
Melanoma recurrent	12.68	11.15	7	243462	79	46442514
Monoclonal gammopathy	12.68	11.15	16	243453	611	46441982
Mycobacterial infection	12.67	11.15	27	243442	1606	46440987
Post procedural haemorrhage	12.67	11.15	12	243457	7414	46435179
Coxsackie viral infection	12.64	11.15	5	243464	24	46442569
Erythema migrans	12.64	11.15	5	243464	24	46442569
Marrow hyperplasia	12.64	11.15	15	243454	537	46442056
T-cell lymphoma	12.64	11.15	16	243453	613	46441980
Pulse absent	12.63	11.15	5	243464	4951	46437642
Renal tubular necrosis	12.60	11.15	23	243446	10736	46431857
Eye pruritus	12.59	11.15	27	243442	11871	46430722
Walking aid user	12.55	11.15	54	243415	4746	46437847
Viral sepsis	12.48	11.15	5	243464	25	46442568
Fracture	12.47	11.15	44	243425	16427	46426166
Product dispensing error	12.44	11.15	18	243451	9215	46433378
Metastases to lung	12.41	11.15	23	243446	10673	46431920
Psychiatric symptom	12.38	11.15	4	243465	4493	46438100
Biopsy bone marrow abnormal	12.37	11.15	11	243458	278	46442315
Dermatitis acneiform	12.36	11.15	3	243466	4067	46438526
Pharyngeal disorder	12.31	11.15	26	243443	1537	46441056
Frustration tolerance decreased	12.30	11.15	6	243463	5251	46437342
Gastrointestinal motility disorder	12.30	11.15	4	243465	4474	46438119
Dermatitis bullous	12.30	11.15	13	243456	7630	46434963
Photophobia	12.29	11.15	37	243432	14507	46428086
Hyperreflexia	12.29	11.15	6	243463	5248	46437345
Impaired work ability	12.26	11.15	110	243359	12526	46430067
Lung diffusion test decreased	12.26	11.15	16	243453	632	46441961
Eyelid oedema	12.26	11.15	22	243447	10335	46432258
Blood lactate dehydrogenase increased	12.25	11.15	162	243307	20338	46422255
Tuberculin test positive	12.24	11.15	39	243430	2965	46439628
Facial pain	12.23	11.15	13	243456	7612	46434981
Internal haemorrhage	12.20	11.15	4	243465	4451	46438142
Muscle tightness	12.09	11.15	22	243447	10283	46432310
CD8 lymphocytes decreased	12.06	11.15	9	243460	176	46442417
Gastroenteritis viral	12.04	11.15	51	243418	18068	46424525
Toxic cardiomyopathy	12.04	11.15	8	243461	129	46442464
Hepatitis B DNULL assay positive	12.02	11.15	5	243464	28	46442565
Renal vasculitis	12.00	11.15	10	243459	231	46442362
Cerebellar stroke	11.98	11.15	9	243460	178	46442415
Catheter site erythema	11.97	11.15	3	243466	3980	46438613
Proctalgia	11.96	11.15	5	243464	4791	46437802
Epstein Barr virus positive mucocutaneous ulcer	11.96	11.15	10	243459	232	46442361
Connective tissue inflammation	11.94	11.15	6	243463	55	46442538
Joint effusion	11.94	11.15	105	243364	11890	46430703
Activated partial thromboplastin time prolonged	11.91	11.15	11	243458	6878	46435715
Remission not achieved	11.90	11.15	7	243462	90	46442503
Gastroenteritis clostridial	11.89	11.15	14	243455	497	46442096
Thrombotic thrombocytopenic purpura	11.82	11.15	46	243423	3864	46438729
Antineutrophil cytoplasmic antibody increased	11.76	11.15	6	243463	57	46442536
Neutrophil count decreased	11.69	11.15	303	243166	43123	46399470
Lichen sclerosus	11.69	11.15	19	243450	918	46441675
Oligohydramnios	11.67	11.15	7	243462	5458	46437135
Cerebral atrophy	11.63	11.15	5	243464	4711	46437882
Dyspepsia	11.62	11.15	270	243199	68202	46374391
Focal segmental glomerulosclerosis	11.62	11.15	24	243445	1397	46441196
Device use error	11.59	11.15	6	243463	5075	46437518
Autoimmune neutropenia	11.58	11.15	6	243463	59	46442534
Heparin-induced thrombocytopenia	11.57	11.15	4	243465	4305	46438288
Mixed hepatocellular cholangiocarcinoma	11.56	11.15	4	243465	12	46442581
Cranial nerve disorder	11.56	11.15	11	243458	304	46442289
Feeling drunk	11.54	11.15	3	243466	3884	46438709
Thirst	11.53	11.15	25	243444	10951	46431642
Aspiration	11.50	11.15	20	243449	9511	46433082
Arthritis infective	11.49	11.15	55	243414	5058	46437535
Drug dependence	11.47	11.15	59	243410	19842	46422751
Anterograde amnesia	11.44	11.15	12	243457	374	46442219
Ventricular fibrillation	11.42	11.15	27	243442	11469	46431124
Sudden death	11.42	11.15	20	243449	9484	46433109
Blood chloride decreased	11.41	11.15	7	243462	5390	46437203
Campylobacter infection	11.38	11.15	16	243453	679	46441914
Neoplasm malignant	11.38	11.15	179	243290	23320	46419273
Pruritus allergic	11.37	11.15	20	243449	1031	46441562
Brain natriuretic peptide increased	11.36	11.15	5	243464	4645	46437948
Myocarditis infectious	11.33	11.15	4	243465	13	46442580
Polyomavirus viraemia	11.26	11.15	12	243457	381	46442212
Jaw fracture	11.22	11.15	34	243435	2515	46440078
Chest wall tumour	11.21	11.15	5	243464	34	46442559
Central nervous system viral infection	11.20	11.15	7	243462	101	46442492
Electrocardiogram abnormal	11.20	11.15	12	243457	7000	46435593
Medication error	11.20	11.15	105	243364	30806	46411787
Complement factor C3 decreased	11.19	11.15	8	243461	146	46442447
Splenectomy	11.19	11.15	13	243456	455	46442138
Lower gastrointestinal haemorrhage	11.17	11.15	13	243456	7307	46435286
Atrioventricular block second degree	11.15	11.15	3	243466	3796	46438797

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	1359.72	11.60	1975	128182	104718	29717603
Off label use	1066.83	11.60	2915	127242	246375	29575946
Progressive multifocal leukoencephalopathy	1015.44	11.60	577	129580	8436	29813885
Neutropenia	895.74	11.60	1821	128336	126719	29695602
Intentional product use issue	894.92	11.60	940	129217	35500	29786821
Hepatitis B	738.98	11.60	409	129748	5663	29816658
Product use in unapproved indication	691.27	11.60	1187	128970	72506	29749815
Infusion related reaction	554.77	11.60	778	129379	39786	29782535
Diffuse large B-cell lymphoma recurrent	512.69	11.60	227	129930	1865	29820456
Drug ineffective	491.09	11.60	2828	127329	337559	29484762
Diffuse large B-cell lymphoma	490.46	11.60	346	129811	7495	29814826
Pneumocystis jirovecii pneumonia	445.74	11.60	456	129701	16664	29805657
Hypogammaglobulinaemia	437.54	11.60	277	129880	4975	29817346
Myelodysplastic syndrome	395.35	11.60	447	129710	18331	29803990
Hepatitis B reactivation	372.68	11.60	202	129955	2675	29819646
Completed suicide	370.99	11.60	14	130143	99478	29722843
Rheumatoid arthritis	365.45	11.60	648	129509	40549	29781772
Cytomegalovirus infection	344.39	11.60	468	129689	23206	29799115
Apparent death	338.73	11.60	204	129953	3338	29818983
Lymphoma	327.96	11.60	304	129853	9817	29812504
Synovitis	325.06	11.60	298	129859	9485	29812836
Tumour lysis syndrome	322.38	11.60	336	129821	12549	29809772
Drug interaction	316.57	11.60	243	129914	199325	29622996
Bone marrow failure	309.77	11.60	503	129654	29282	29793039
Contraindicated product administered	309.23	11.60	378	129779	16853	29805468
Chills	295.16	11.60	834	129323	71504	29750817
Toxicity to various agents	281.86	11.60	215	129942	176968	29645353
Overdose	259.35	11.60	31	130126	84306	29738015
Chronic lymphocytic leukaemia	259.17	11.60	191	129966	4437	29817884
Fall	250.25	11.60	253	129904	181619	29640702
Drug intolerance	243.15	11.60	579	129578	44712	29777609
Disease progression	239.00	11.60	827	129330	79047	29743274
Pyrexia	221.98	11.60	2099	128058	292390	29529931
Rhabdomyolysis	220.80	11.60	14	130143	63566	29758755
Post transplant lymphoproliferative disorder	215.11	11.60	181	129976	5125	29817196
Diffuse large B-cell lymphoma refractory	208.88	11.60	90	130067	687	29821634
B-cell lymphoma recurrent	208.11	11.60	85	130072	558	29821763
B-cell lymphoma	201.96	11.60	163	129994	4347	29817974
Lymphopenia	201.74	11.60	267	129890	12896	29809425
Therapy partial responder	201.45	11.60	150	130007	3541	29818780
Agranulocytosis	195.55	11.60	346	129811	21596	29800725
Pancytopenia	191.19	11.60	804	129353	84248	29738073
Product dose omission issue	190.18	11.60	80	130077	91551	29730770
Neutrophil count decreased	184.39	11.60	501	129656	41953	29780368
Treatment failure	181.41	11.60	439	129718	34240	29788081
Chronic lymphocytic leukaemia recurrent	177.08	11.60	68	130089	370	29821951
Lymphadenopathy	176.88	11.60	352	129805	24024	29798297
Second primary malignancy	173.95	11.60	174	129983	6182	29816139
Cytopenia	172.79	11.60	196	129961	8060	29814261
Joint swelling	171.89	11.60	521	129636	46425	29775896
Infection	166.92	11.60	727	129430	77347	29744974
Disease recurrence	164.95	11.60	252	129905	13909	29808412
Febrile bone marrow aplasia	160.66	11.60	187	129970	7910	29814411
Neutropenic sepsis	159.00	11.60	221	129936	11188	29811133
Dizziness	156.10	11.60	389	129768	194520	29627801
Bronchopulmonary aspergillosis	152.19	11.60	225	129932	12059	29810262
Anxiety	150.57	11.60	103	130054	89768	29732553
Somnolence	150.36	11.60	120	130037	96643	29725678
Plasma cell myeloma	149.54	11.60	26	130131	53436	29768885
Mantle cell lymphoma recurrent	147.51	11.60	59	130098	364	29821957
B-lymphocyte count decreased	145.80	11.60	61	130096	429	29821892
Autoimmune haemolytic anaemia	145.36	11.60	129	130028	3930	29818391
Acquired gene mutation	143.40	11.60	79	130078	1082	29821239
Diverticulitis	140.11	11.60	263	129894	17182	29805139
Leukopenia	137.28	11.60	545	129612	55614	29766707
Hypoglycaemia	135.77	11.60	28	130129	50953	29771368
Epstein-Barr virus infection	134.93	11.60	156	130001	6550	29815771
Suicide attempt	130.67	11.60	7	130150	36690	29785631
Hallucination	128.48	11.60	28	130129	49031	29773290
Mantle cell lymphoma	127.64	11.60	81	130076	1460	29820861
Sepsis	123.25	11.60	1070	129087	145325	29676996
Mucosal inflammation	122.64	11.60	350	129807	30144	29792177
Fatigue	119.52	11.60	860	129297	319813	29502508
International normalised ratio increased	115.75	11.60	32	130125	47707	29774614
Herpes zoster	114.94	11.60	338	129819	29605	29792716
Hospitalisation	114.63	11.60	26	130131	44293	29778028
White blood cell count decreased	111.80	11.60	685	129472	83262	29739059
Aggression	109.92	11.60	15	130142	36892	29785429
Pneumocystis jirovecii infection	109.67	11.60	70	130087	1275	29821046
Red blood cell sedimentation rate increased	108.73	11.60	146	130011	7149	29815172
Suicidal ideation	106.79	11.60	15	130142	36099	29786222
Thrombocytopenia	106.26	11.60	984	129173	136060	29686261
Electrocardiogram QT prolonged	105.70	11.60	15	130142	35820	29786501
Chondropathy	104.54	11.60	58	130099	806	29821515
Haematotoxicity	103.67	11.60	131	130026	6039	29816282
Central nervous system lymphoma	103.55	11.60	58	130099	822	29821499
Diarrhoea	102.05	11.60	945	129212	333158	29489163
Acute myeloid leukaemia	101.78	11.60	235	129922	17771	29804550
Muscle spasms	101.19	11.60	80	130077	64758	29757563
Pneumonia cytomegaloviral	100.40	11.60	89	130068	2707	29819614
Depression	99.71	11.60	149	130008	90288	29732033
Confusional state	99.53	11.60	280	129877	134554	29687767
Gait disturbance	99.27	11.60	107	130050	74670	29747651
Cerebrovascular accident	97.51	11.60	132	130025	83345	29738976
Granulomatosis with polyangiitis	96.91	11.60	56	130101	845	29821476
Aspergillus infection	96.10	11.60	165	129992	10049	29812272
Vomiting	95.71	11.60	562	129595	219256	29603065
Inappropriate schedule of product administration	95.62	11.60	27	130130	39701	29782620
Blood creatine phosphokinase increased	94.64	11.60	36	130121	43812	29778509
Onychoclasis	94.08	11.60	69	130088	1590	29820731
Squamous cell carcinoma	93.06	11.60	163	129994	10087	29812234
Intentional product misuse	92.37	11.60	19	130138	34648	29787673
Mineral metabolism disorder	92.31	11.60	40	130117	310	29822011
Pulmonary embolism	91.36	11.60	617	129540	77518	29744803
Atlantoaxial instability	91.03	11.60	39	130118	293	29822028
Pulmonary thrombosis	90.07	11.60	124	130033	6219	29816102
Spinal instability	89.48	11.60	39	130118	307	29822014
Myelosuppression	89.09	11.60	133	130024	7189	29815132
Sarcoidosis	88.44	11.60	82	130075	2647	29819674
Agitation	85.27	11.60	66	130091	54007	29768314
Dislocation of vertebra	84.44	11.60	39	130118	357	29821964
Serum sickness	82.92	11.60	66	130091	1724	29820597
Myocardial infarction	82.62	11.60	275	129882	125350	29696971
Psoriasis	82.07	11.60	41	130116	42465	29779856
JC virus infection	80.79	11.60	65	130092	1725	29820596
Seizure	80.66	11.60	194	129963	98281	29724040
Cardio-respiratory arrest	80.59	11.60	78	130079	57228	29765093
Knee arthroplasty	79.85	11.60	110	130047	5520	29816801
Arthropathy	79.56	11.60	234	129923	20493	29801828
Coronary artery disease	77.98	11.60	61	130096	49651	29772670
Cytomegalovirus chorioretinitis	77.76	11.60	83	130074	3185	29819136
Decreased appetite	76.48	11.60	363	129794	149547	29672774
Cardiac arrest	75.19	11.60	184	129973	92666	29729655
Dehydration	72.89	11.60	283	129874	123256	29699065
Foot deformity	72.60	11.60	82	130075	3355	29818966
Acute kidney injury	71.31	11.60	804	129353	273038	29549283
Acne cystic	70.85	11.60	37	130120	452	29821869
Cytokine release syndrome	70.30	11.60	142	130015	9791	29812530
Bradycardia	70.24	11.60	110	130047	65416	29756905
Pneumonitis	69.92	11.60	270	129887	27184	29795137
Cardiac failure congestive	69.34	11.60	166	129991	84241	29738080
Loss of consciousness	69.33	11.60	151	130006	79224	29743097
Myalgia	68.51	11.60	144	130013	76523	29745798
Lymphoma transformation	67.47	11.60	26	130131	143	29822178
Drug withdrawal syndrome	66.88	11.60	5	130152	19804	29802517
Hyperkalaemia	65.94	11.60	116	130041	65894	29756427
Intervertebral disc space narrowing	65.88	11.60	39	130118	617	29821704
Memory impairment	65.76	11.60	40	130117	37134	29785187
C-reactive protein increased	65.75	11.60	367	129790	43106	29779215
Haemolysis	65.65	11.60	115	130042	7116	29815205
Coma	65.53	11.60	48	130109	40401	29781920
Septic shock	65.41	11.60	487	129670	63120	29759201
Ill-defined disorder	65.03	11.60	142	130015	10342	29811979
Wrong technique in product usage process	64.90	11.60	27	130130	31128	29791193
Herpes simplex	64.49	11.60	88	130069	4376	29817945
Interstitial lung disease	64.25	11.60	465	129692	59732	29762589
Pemphigus	63.84	11.60	49	130108	1212	29821109
No adverse event	63.39	11.60	193	129964	17226	29805095
Constipation	63.22	11.60	264	129893	112642	29709679
Blood pressure diastolic abnormal	62.95	11.60	49	130108	1238	29821083
Dyskinesia	62.41	11.60	10	130147	21824	29800497
Hyperpyrexia	62.29	11.60	66	130091	2511	29819810
Irritability	60.65	11.60	13	130144	23037	29799284
Accidental overdose	60.61	11.60	5	130152	18270	29804051
Pneumonia	60.00	11.60	1887	128270	332419	29489902
Metabolic acidosis	59.98	11.60	45	130112	37416	29784905
Platelet count decreased	59.95	11.60	715	129442	105414	29716907
Malaise	59.92	11.60	452	129705	166510	29655811
Injury	59.81	11.60	11	130146	21720	29800601
B-cell lymphoma refractory	59.80	11.60	22	130135	104	29822217
Insomnia	59.51	11.60	207	129950	93129	29729192
Treatment noncompliance	59.23	11.60	18	130139	25235	29797086
Injection site pain	58.87	11.60	29	130128	30281	29792040
Hyponatraemia	58.55	11.60	128	130029	67074	29755247
Syncope	58.47	11.60	182	129975	84721	29737600
Basal cell carcinoma	58.44	11.60	178	129979	15890	29806431
Coombs positive haemolytic anaemia	57.91	11.60	38	130119	727	29821594
Nausea	57.64	11.60	926	129231	296031	29526290
Venoocclusive liver disease	57.24	11.60	103	130054	6510	29815811
Bladder transitional cell carcinoma	56.08	11.60	61	130096	2392	29819929
Hepatic failure	54.57	11.60	292	129865	33751	29788570
Encephalitis enteroviral	54.17	11.60	22	130135	142	29822179
Diabetic ketoacidosis	54.07	11.60	4	130153	15982	29806339
Synovial cyst	53.79	11.60	51	130106	1694	29820627
Unevaluable event	53.75	11.60	36	130121	31749	29790572
Abnormal behaviour	53.70	11.60	22	130135	25601	29796720
Terminal state	53.51	11.60	72	130085	3532	29818789
Oxygen saturation decreased	53.12	11.60	347	129810	43093	29779228
Posterior reversible encephalopathy syndrome	52.94	11.60	117	130040	8590	29813731
Hepatitis E	52.81	11.60	49	130108	1583	29820738
Cytomegalovirus infection reactivation	52.63	11.60	50	130107	1665	29820656
Rheumatoid factor positive	52.50	11.60	31	130126	488	29821833
Tooth loss	52.50	11.60	75	130082	3894	29818427
Blood pressure systolic abnormal	52.19	11.60	47	130110	1460	29820861
Hallucination, visual	51.84	11.60	5	130152	16108	29806213
Cytology abnormal	51.56	11.60	28	130129	372	29821949
Respiratory arrest	51.03	11.60	32	130125	29226	29793095
Lethargy	50.82	11.60	58	130099	39461	29782860
Microsporidia infection	50.65	11.60	32	130125	572	29821749
Lymphocytosis	50.38	11.60	52	130105	1918	29820403
Stress	50.10	11.60	13	130144	20222	29802099
Polyneuropathy	48.78	11.60	137	130020	11686	29810635
C-reactive protein abnormal	48.27	11.60	87	130070	5506	29816815
Gastrointestinal haemorrhage	48.01	11.60	193	129964	83253	29739068
Chronic lymphocytic leukaemia refractory	47.79	11.60	18	130139	92	29822229
Osteosclerosis	47.07	11.60	40	130117	1148	29821173
Immunosuppression	46.59	11.60	82	130075	5093	29817228
JC polyomavirus test positive	46.54	11.60	30	130127	556	29821765
Intestinal sepsis	46.46	11.60	27	130130	412	29821909
End stage renal disease	46.45	11.60	101	130056	7334	29814987
Lactic acidosis	45.62	11.60	41	130116	31172	29791149
Medication error	45.61	11.60	17	130140	20955	29801366
Lung infiltration	45.55	11.60	139	130018	12420	29809901
Blood pressure fluctuation	45.26	11.60	173	129984	17330	29804991
Drug ineffective for unapproved indication	44.81	11.60	126	130031	10754	29811567
Deep vein thrombosis	44.08	11.60	429	129728	60072	29762249
Blood urea increased	43.77	11.60	43	130114	31338	29790983
Delirium	43.72	11.60	68	130089	40563	29781758
Immunoglobulins decreased	42.77	11.60	31	130126	701	29821620
Haematemesis	42.56	11.60	31	130126	26172	29796149
Asthenia	42.54	11.60	691	129466	220599	29601722
Blood glucose increased	42.27	11.60	132	130025	61398	29760923
Graft versus host disease	42.25	11.60	118	130039	10032	29812289
Polyarthritis	42.11	11.60	61	130096	3208	29819113
Depressed level of consciousness	42.06	11.60	63	130094	38159	29784162
Blood immunoglobulin A decreased	41.97	11.60	21	130136	233	29822088
Haemophagocytic lymphohistiocytosis	41.92	11.60	115	130042	9676	29812645
Prerenal failure	41.86	11.60	46	130111	1825	29820496
Restlessness	41.84	11.60	23	130134	22576	29799745
Humoral immune defect	41.80	11.60	14	130143	47	29822274
Lymphadenitis	41.48	11.60	44	130113	1676	29820645
Melaena	41.28	11.60	48	130109	32389	29789932
Vision blurred	41.28	11.60	74	130083	41742	29780579
Disability	41.07	11.60	71	130086	4347	29817974
Chest pain	40.95	11.60	321	129836	117306	29705015
Nightmare	40.90	11.60	3	130154	12073	29810248
Osteoarthritis	40.77	11.60	173	129984	18176	29804145
Drug tolerance decreased	40.47	11.60	36	130121	1100	29821221
Pulmonary fibrosis	40.22	11.60	156	130001	15734	29806587
Joint arthroplasty	39.96	11.60	28	130129	599	29821722
Candida infection	39.86	11.60	152	130005	15210	29807111
Therapeutic product effect decreased	39.74	11.60	239	129918	28837	29793484
Psychotic disorder	39.68	11.60	22	130135	21493	29800828
Immune thrombocytopenia	39.55	11.60	96	130061	7495	29814826
Immunoglobulin G4 related disease	39.46	11.60	15	130142	79	29822242
Dysgeusia	39.43	11.60	30	130127	24771	29797550
Product prescribing error	39.11	11.60	12	130145	16721	29805600
Gamma-glutamyltransferase increased	38.92	11.60	42	130115	29308	29793013
Drug resistance	38.84	11.60	182	129975	19951	29802370
Erectile dysfunction	38.82	11.60	15	130142	18087	29804234
Epstein-Barr viraemia	38.68	11.60	32	130125	884	29821437
Asthma	38.49	11.60	61	130096	36113	29786208
Depressed mood	38.41	11.60	13	130144	17016	29805305
Hand deformity	38.40	11.60	44	130113	1829	29820492
Gastritis bacterial	38.21	11.60	18	130139	173	29822148
Blood immunoglobulin G decreased	37.96	11.60	32	130125	908	29821413
Tooth fracture	37.90	11.60	58	130099	3204	29819117
Mantle cell lymphoma refractory	37.85	11.60	15	130142	90	29822231
Pain in extremity	37.80	11.60	302	129855	109919	29712402
5q minus syndrome	37.74	11.60	17	130140	146	29822175
Therapy non-responder	37.68	11.60	238	129919	29215	29793106
Extravasation	37.57	11.60	43	130114	1785	29820536
Drug dependence	37.54	11.60	23	130134	21272	29801049
Transplant rejection	37.31	11.60	106	130051	9100	29813221
Incorrect dose administered	37.07	11.60	50	130107	31636	29790685
Therapy cessation	36.95	11.60	10	130147	15127	29807194
Haemoglobin abnormal	36.87	11.60	56	130101	3073	29819248
Orthostatic hypotension	36.87	11.60	30	130127	23949	29798372
Cerebral aspergillosis	36.83	11.60	37	130120	1321	29821000
Sweat gland tumour	36.76	11.60	23	130134	404	29821917
Arthritis bacterial	36.70	11.60	68	130089	4396	29817925
Angioedema	36.56	11.60	58	130099	34326	29787995
Sopor	36.47	11.60	3	130154	10988	29811333
Disorientation	36.33	11.60	50	130107	31368	29790953
Aspartate aminotransferase increased	36.27	11.60	147	130010	63275	29759046
Glomerulonephritis	36.17	11.60	42	130115	1771	29820550
Pseudomonas infection	36.15	11.60	114	130043	10368	29811953
Emotional distress	35.61	11.60	12	130145	15753	29806568
Neoplasm progression	35.56	11.60	164	129993	17859	29804462
Therapeutic response decreased	35.12	11.60	203	129954	24146	29798175
Liver function test abnormal	35.05	11.60	50	130107	30900	29791421
Pulmonary toxicity	34.90	11.60	67	130090	4449	29817872
Platelet count abnormal	34.86	11.60	47	130110	2310	29820011
Labelled drug-drug interaction medication error	34.62	11.60	3	130154	10535	29811786
Mental status changes	34.50	11.60	68	130089	37011	29785310
Oedema peripheral	34.46	11.60	294	129863	105538	29716783
Hip fracture	34.38	11.60	4	130153	11120	29811201
Anger	34.36	11.60	4	130153	11116	29811205
Vasculitis	34.36	11.60	94	130063	7896	29814425
Abdominal distension	34.34	11.60	94	130063	45615	29776706
Scleroderma	33.89	11.60	35	130122	1292	29821029
Bone marrow infiltration	33.52	11.60	14	130143	98	29822223
Product quality issue	33.48	11.60	20	130137	18754	29803567
Refractory anaemia with an excess of blasts	33.26	11.60	21	130136	375	29821946
Delusion	33.14	11.60	6	130151	11983	29810338
Sleep disorder due to general medical condition, insomnia type	32.97	11.60	33	130124	1173	29821148
Lymphoplasmacytoid lymphoma/immunocytoma	32.83	11.60	11	130146	37	29822284
BK virus infection	32.82	11.60	64	130093	4300	29818021
Cerebral haemorrhage	32.63	11.60	58	130099	32829	29789492
Pancreatitis	32.18	11.60	69	130088	36421	29785900
Viral haemorrhagic cystitis	32.10	11.60	28	130129	833	29821488
Congenital cardiovascular anomaly	31.86	11.60	16	130141	179	29822142
Pancreatitis acute	31.65	11.60	39	130118	25656	29796665
Acute lung injury	31.57	11.60	31	130126	1076	29821245
Adenovirus infection	31.38	11.60	62	130095	4206	29818115
Gait inability	30.98	11.60	22	130135	18819	29803502
Muscle rigidity	30.95	11.60	4	130153	10257	29812064
Wrist deformity	30.90	11.60	19	130138	323	29821998
Blood alkaline phosphatase increased	30.82	11.60	56	130101	31431	29790890
Road traffic accident	30.70	11.60	18	130139	17053	29805268
Hyperlipidaemia	30.70	11.60	11	130146	13896	29808425
Ventricular tachycardia	30.70	11.60	35	130122	23827	29798494
Periostitis	30.65	11.60	17	130140	236	29822085
Unresponsive to stimuli	30.59	11.60	42	130115	26377	29795944
Head injury	30.54	11.60	18	130139	17002	29805319
Febrile infection	30.27	11.60	37	130120	1648	29820673
Enterovirus infection	30.10	11.60	23	130134	565	29821756
Fluid retention	29.70	11.60	39	130118	24959	29797362
Neuromyelitis optica spectrum disorder	29.68	11.60	14	130143	135	29822186
Exposure during pregnancy	29.46	11.60	3	130154	9258	29813063
Faeces discoloured	29.18	11.60	12	130145	13934	29808387
Hypoaesthesia	28.97	11.60	129	130028	54101	29768220
Enterococcal infection	28.87	11.60	90	130067	8134	29814187
Pneumonia fungal	28.86	11.60	70	130087	5463	29816858
Dry skin	28.81	11.60	33	130124	22421	29799900
Hepatitis B surface antigen positive	28.53	11.60	13	130144	115	29822206
Marginal zone lymphoma	28.40	11.60	9	130148	24	29822297
Glomerulonephritis membranoproliferative	28.35	11.60	19	130138	377	29821944
Babesiosis	28.32	11.60	11	130146	62	29822259
Immunodeficiency common variable	28.16	11.60	14	130143	153	29822168
Autoimmune lymphoproliferative syndrome	28.16	11.60	14	130143	153	29822168
Post procedural complication	28.15	11.60	8	130149	11718	29810603
Microscopic polyangiitis	28.14	11.60	13	130144	119	29822202
Escherichia sepsis	28.14	11.60	57	130100	3937	29818384
Herpes simplex encephalitis	27.96	11.60	17	130140	283	29822038
Meningitis cryptococcal	27.88	11.60	39	130118	1985	29820336
Non-Hodgkin's lymphoma	27.56	11.60	36	130121	1715	29820606
Injection site swelling	27.53	11.60	3	130154	8777	29813544
Hyperglycaemia	27.49	11.60	71	130086	35129	29787192
Swelling face	27.39	11.60	31	130126	21173	29801148
Prostatic specific antigen increased	27.36	11.60	9	130148	11995	29810326
Sleep disorder	27.27	11.60	40	130117	24439	29797882
Neoplasm recurrence	27.26	11.60	37	130120	1830	29820491
Pneumonia klebsiella	27.25	11.60	44	130113	2546	29819775
Abscess	27.21	11.60	101	130056	9977	29812344
Paraneoplastic pemphigus	27.09	11.60	11	130146	71	29822250
Epstein-Barr virus associated lymphoma	27.03	11.60	21	130136	529	29821792
Human herpesvirus 8 infection	26.89	11.60	23	130134	666	29821655
Amnesia	26.84	11.60	40	130117	24281	29798040
Cryoglobulinaemia	26.81	11.60	17	130140	306	29822015
Chronic allograft nephropathy	26.66	11.60	29	130128	1137	29821184
Lip swelling	26.61	11.60	11	130146	12733	29809588
Dystonia	26.60	11.60	5	130152	9722	29812599
Adverse drug reaction	26.59	11.60	37	130120	23108	29799213
Abdominal pain upper	26.54	11.60	161	129996	62390	29759931
Rib fracture	26.52	11.60	11	130146	12709	29809612
Acute myocardial infarction	26.46	11.60	129	130028	52810	29769511
Musculoskeletal stiffness	26.40	11.60	255	129902	35626	29786695
Traumatic lung injury	26.36	11.60	29	130128	1152	29821169
Chronic graft versus host disease	25.78	11.60	56	130101	4063	29818258
Mucormycosis	25.73	11.60	65	130092	5203	29817118
Cardiac disorder	25.72	11.60	88	130069	39805	29782516
Hypertension	25.62	11.60	372	129785	120982	29701339
Headache	25.61	11.60	600	129557	181706	29640615
Atypical pneumonia	25.61	11.60	44	130113	2680	29819641
Thrombotic microangiopathy	25.55	11.60	89	130068	8521	29813800
Pneumonia adenoviral	25.54	11.60	13	130144	150	29822171
Splenic marginal zone lymphoma	25.47	11.60	9	130148	37	29822284
Osteonecrosis of jaw	25.40	11.60	26	130131	18592	29803729
West Nile viral infection	25.39	11.60	21	130136	580	29821741
Medical device implantation	25.37	11.60	20	130137	515	29821806
Bacterial sepsis	25.35	11.60	62	130095	4864	29817457
Pneumonia escherichia	25.34	11.60	17	130140	338	29821983
Chronic lymphocytic leukaemia transformation	25.33	11.60	14	130143	193	29822128
Psychomotor hyperactivity	25.31	11.60	3	130154	8221	29814100
Colitis	25.17	11.60	224	129933	30596	29791725
Herpes virus infection	25.12	11.60	42	130115	2502	29819819
Peritonitis bacterial	25.12	11.60	9	130148	11369	29810952
Pseudomonal sepsis	25.04	11.60	46	130111	2954	29819367
Intestinal obstruction	24.91	11.60	28	130129	19184	29803137
Device malfunction	24.86	11.60	3	130154	8108	29814213
Disturbance in attention	24.80	11.60	36	130121	22093	29800228
Hypokalaemia	24.69	11.60	123	130034	50069	29772252
Bacteraemia	24.61	11.60	133	130024	15427	29806894
Dyspnoea	24.60	11.60	1191	128966	332104	29490217
Pneumonia aspiration	24.59	11.60	83	130074	37697	29784624
Blood pressure systolic increased	24.47	11.60	130	130027	14980	29807341
Erysipelas	24.42	11.60	58	130099	4466	29817855
CD4 lymphocytes decreased	24.33	11.60	37	130120	2033	29820288
Prescribed overdose	24.29	11.60	4	130153	8557	29813764
Encephalitis viral	24.28	11.60	28	130129	1172	29821149
Nasal cavity cancer	24.07	11.60	12	130145	132	29822189
Skin discolouration	23.98	11.60	20	130137	15774	29806547
Flatulence	23.97	11.60	26	130131	18103	29804218
Cellulitis gangrenous	23.86	11.60	13	130144	174	29822147
Temperature intolerance	23.85	11.60	45	130112	2950	29819371
COVID-19	23.82	11.60	146	130011	17732	29804589
Haematochezia	23.79	11.60	73	130084	34149	29788172
Hypocalcaemia	23.74	11.60	35	130122	21341	29800980
Fluoride increased	23.74	11.60	9	130148	47	29822274
Cytomegalovirus test positive	23.32	11.60	50	130107	3595	29818726
Stomatitis	23.18	11.60	256	129901	37023	29785298
Blood glucose decreased	23.14	11.60	14	130143	13039	29809282
Graft versus host disease in skin	23.07	11.60	47	130110	3260	29819061
Blood potassium decreased	23.04	11.60	23	130134	16639	29805682
Human herpesvirus 6 infection	23.01	11.60	35	130122	1923	29820398
Underdose	23.00	11.60	12	130145	12129	29810192
Prothrombin time prolonged	22.98	11.60	6	130151	9297	29813024
Cystitis escherichia	22.98	11.60	13	130144	188	29822133
Hallucination, auditory	22.91	11.60	7	130150	9782	29812539
Lung disorder	22.83	11.60	223	129934	31246	29791075
Diaphragm muscle weakness	22.81	11.60	10	130147	80	29822241
Hypercholesterolaemia	22.80	11.60	3	130154	7589	29814732
Blood immunoglobulin M increased	22.80	11.60	13	130144	191	29822130
Cytomegalovirus gastritis	22.74	11.60	13	130144	192	29822129
Haemolytic anaemia	22.72	11.60	95	130062	9915	29812406
Intestinal perforation	22.68	11.60	85	130072	8434	29813887
Psoriatic arthropathy	22.67	11.60	21	130136	15740	29806581
Balance disorder	22.52	11.60	82	130075	36411	29785910
Cardiomegaly	22.49	11.60	18	130139	14491	29807830
Burning sensation	22.48	11.60	23	130134	16451	29805870
Rhinovirus infection	22.43	11.60	43	130114	2852	29819469
Small intestinal perforation	22.32	11.60	32	130125	1667	29820654
Neuroborreliosis	22.27	11.60	7	130150	18	29822303
Chylothorax	22.24	11.60	20	130137	620	29821701
Human rhinovirus test positive	21.93	11.60	12	130145	162	29822159
Device related thrombosis	21.86	11.60	22	130135	787	29821534
Glycosylated haemoglobin increased	21.83	11.60	7	130150	9484	29812837
Hepatitis fulminant	21.78	11.60	51	130106	3890	29818431
Chromaturia	21.75	11.60	17	130140	13848	29808473
Bone marrow reticulin fibrosis	21.74	11.60	12	130145	165	29822156
Incorrect route of product administration	21.70	11.60	11	130146	11304	29811017
Acquired C1 inhibitor deficiency	21.61	11.60	6	130151	8	29822313
Tumour flare	21.49	11.60	18	130139	506	29821815
Hip arthroplasty	21.33	11.60	49	130108	3691	29818630
Encephalitis	21.29	11.60	69	130088	6367	29815954
Alanine aminotransferase increased	21.28	11.60	213	129944	74063	29748258
Miosis	21.26	11.60	4	130153	7772	29814549
Neurological decompensation	21.10	11.60	37	130120	2291	29820030
Abdominal lymphadenopathy	21.05	11.60	18	130139	521	29821800
Pneumonia viral	21.04	11.60	40	130117	2637	29819684
Secondary immunodeficiency	21.01	11.60	15	130142	331	29821990
Neutropenic infection	20.78	11.60	24	130133	1006	29821315
Morphoea	20.67	11.60	11	130146	140	29822181
Infusion site discolouration	20.63	11.60	10	130147	103	29822218
Blood immunoglobulin M decreased	20.63	11.60	16	130141	402	29821919
Epistaxis	20.62	11.60	140	130017	52841	29769480
Infection reactivation	20.60	11.60	23	130134	929	29821392
Escherichia infection	20.58	11.60	68	130089	6337	29815984
Postural tremor	20.54	11.60	14	130143	286	29822035
Limb deformity	20.54	11.60	17	130140	470	29821851
Intestinal atresia	20.53	11.60	9	130148	72	29822249
Hypophagia	20.49	11.60	41	130116	22195	29800126
Epstein-Barr virus associated lymphoproliferative disorder	20.47	11.60	31	130126	1697	29820624
Paraesthesia	20.43	11.60	145	130012	54182	29768139
Nervousness	20.40	11.60	13	130144	11775	29810546
Blood stem cell transplant failure	20.39	11.60	16	130141	409	29821912
Thirst	20.27	11.60	3	130154	6946	29815375
Noninfectious myelitis	20.12	11.60	6	130151	12	29822309
Antineutrophil cytoplasmic antibody increased	20.12	11.60	6	130151	12	29822309
Jejunal perforation	20.04	11.60	12	130145	194	29822127
Marginal zone lymphoma recurrent	19.96	11.60	7	130150	28	29822293
T-lymphocyte count decreased	19.88	11.60	12	130145	197	29822124
Vocal cord paralysis	19.88	11.60	21	130136	796	29821525
Generalised tonic-clonic seizure	19.83	11.60	34	130123	19517	29802804
Hairy cell leukaemia	19.81	11.60	9	130148	79	29822242
Mitral valve incompetence	19.80	11.60	17	130140	13217	29809104
Gene mutation	19.79	11.60	21	130136	800	29821521
Non-Hodgkin's lymphoma recurrent	19.76	11.60	7	130150	29	29822292
Hepatic infection fungal	19.75	11.60	11	130146	154	29822167
Pulmonary sarcoidosis	19.75	11.60	18	130139	568	29821753
Therapeutic response unexpected	19.72	11.60	7	130150	8896	29813425
High-grade B-cell lymphoma	19.69	11.60	11	130146	155	29822166
Frequent bowel movements	19.69	11.60	6	130151	8399	29813922
Oedema	19.66	11.60	108	130049	42885	29779436
Chronic kidney disease	19.61	11.60	91	130066	37747	29784574
Transient ischaemic attack	19.55	11.60	51	130106	25149	29797172
Dry mouth	19.49	11.60	44	130113	22806	29799515
Contusion	19.49	11.60	70	130087	31210	29791111
Cytomegalovirus viraemia	19.47	11.60	62	130095	5667	29816654
Gastric stenosis	19.39	11.60	7	130150	31	29822290
Rectal haemorrhage	19.33	11.60	82	130075	34857	29787464
Atrial septal defect	19.30	11.60	3	130154	6698	29815623
Neuropathy peripheral	19.28	11.60	421	129736	70054	29752267
Abdominal pain	19.16	11.60	446	129711	135208	29687113
Neurofibrosarcoma	19.04	11.60	7	130150	33	29822288
Paresis	19.03	11.60	31	130126	1807	29820514
Blood pressure diastolic increased	19.01	11.60	39	130118	2719	29819602
Urinary retention	19.00	11.60	76	130081	32841	29789480
Isosporiasis	18.88	11.60	9	130148	89	29822232
Hypersomnia	18.88	11.60	13	130144	11303	29811018
Encephalitis cytomegalovirus	18.77	11.60	15	130142	394	29821927
Adenocarcinoma gastric	18.64	11.60	24	130133	1127	29821194
Neoplasm malignant	18.63	11.60	137	130020	17677	29804644
Systemic infection	18.62	11.60	19	130138	691	29821630
Myocardial ischaemia	18.61	11.60	29	130128	17288	29805033
Salivary hypersecretion	18.46	11.60	5	130152	7561	29814760
Diffuse large B-cell lymphoma stage IV	18.45	11.60	12	130145	226	29822095
Organising pneumonia	18.25	11.60	56	130101	5018	29817303
Nervous system disorder	18.22	11.60	108	130049	12961	29809360
Encephalitis Japanese B	18.18	11.60	6	130151	19	29822302
Respiratory depression	18.17	11.60	14	130143	11489	29810832
Diabetes mellitus	18.15	11.60	107	130050	41758	29780563
Neutrophil Pelger-Huet anomaly present	18.00	11.60	12	130145	236	29822085
Cytomegalovirus oesophagitis	17.96	11.60	12	130145	237	29822084
Splenomegaly	17.90	11.60	110	130047	13370	29808951
Metastases to bone marrow	17.87	11.60	16	130141	493	29821828
Ear pruritus	17.87	11.60	12	130145	239	29822082
Adenoviral haemorrhagic cystitis	17.81	11.60	15	130142	425	29821896
Hairy cell leukaemia recurrent	17.77	11.60	4	130153	0	29822321
Glomerulonephritis rapidly progressive	17.75	11.60	15	130142	427	29821894
Hepatic amoebiasis	17.73	11.60	8	130149	69	29822252
Hypomagnesaemia	17.64	11.60	28	130129	16570	29805751
Procalcitonin increased	17.62	11.60	23	130134	1095	29821226
Blood sodium decreased	17.57	11.60	26	130131	15830	29806491
Hepatitis D	17.53	11.60	7	130150	43	29822278
Product administration error	17.52	11.60	22	130135	14355	29807966
Superior mesenteric artery syndrome	17.44	11.60	8	130149	72	29822249
Feeling abnormal	17.43	11.60	160	129997	56596	29765725
Mania	17.41	11.60	9	130148	9145	29813176
Respiratory failure	17.37	11.60	566	129591	100076	29722245
White blood cell count abnormal	17.36	11.60	37	130120	2649	29819672
Hypotension	17.36	11.60	704	129453	199861	29622460
Device related infection	17.31	11.60	130	130027	16885	29805436
Dermatitis exfoliative generalised	17.31	11.60	38	130119	2777	29819544
Central nervous system enteroviral infection	17.26	11.60	7	130150	45	29822276
Rheumatoid factor	17.25	11.60	8	130149	74	29822247
Tricuspid valve incompetence	17.12	11.60	8	130149	8615	29813706
Central nervous system fungal infection	17.12	11.60	12	130145	257	29822064
Sensitivity to weather change	17.10	11.60	26	130131	1428	29820893
Pleural effusion	17.05	11.60	432	129725	73634	29748687
Cystitis viral	17.04	11.60	15	130142	452	29821869
Throat irritation	17.02	11.60	78	130079	8470	29813851
Antineutrophil cytoplasmic antibody positive	16.98	11.60	15	130142	454	29821867
Nephrotic syndrome	16.94	11.60	67	130090	6818	29815503
Peripheral coldness	16.74	11.60	4	130153	6579	29815742
Prostatic abscess	16.73	11.60	14	130143	393	29821928
Inappropriate antidiuretic hormone secretion	16.69	11.60	15	130142	11407	29810914
Tenderness	16.66	11.60	59	130098	5696	29816625
Granuloma skin	16.61	11.60	12	130145	270	29822051
Dysarthria	16.60	11.60	72	130085	30418	29791903
Poisoning	16.57	11.60	15	130142	11367	29810954
Speech disorder	16.53	11.60	53	130104	24459	29797862
Cerebral infarction	16.44	11.60	59	130098	26314	29796007
Transformation to acute myeloid leukaemia	16.43	11.60	17	130140	629	29821692
Haematocrit decreased	16.40	11.60	73	130084	30626	29791695
Accidental exposure to product	16.38	11.60	12	130145	10103	29812218
Human polyomavirus infection	16.34	11.60	17	130140	633	29821688
Disseminated cytomegaloviral infection	16.27	11.60	10	130147	170	29822151
Granulocytopenia neonatal	16.20	11.60	6	130151	29	29822292
Primary mediastinal large B-cell lymphoma	16.15	11.60	5	130152	12	29822309
B-lymphocyte count increased	16.15	11.60	5	130152	12	29822309
Klebsiella infection	16.13	11.60	66	130091	6821	29815500
Lymphoproliferative disorder	16.12	11.60	33	130124	2297	29820024
Systemic mycosis	16.11	11.60	23	130134	1193	29821128
Varicella	16.11	11.60	26	130131	1504	29820817
Oropharyngeal squamous cell carcinoma	16.04	11.60	9	130148	128	29822193
Upper gastrointestinal haemorrhage	16.02	11.60	46	130111	21982	29800339
Cytomegalovirus enterocolitis	16.00	11.60	19	130138	821	29821500
Strongyloidiasis	15.96	11.60	33	130124	2313	29820008
Arteriosclerosis coronary artery	15.95	11.60	15	130142	11161	29811160
Device issue	15.91	11.60	7	130150	7809	29814512
Coronary artery occlusion	15.89	11.60	15	130142	11142	29811179
Gastrosplenic fistula	15.88	11.60	6	130151	31	29822290
Heart rate decreased	15.83	11.60	150	130007	20844	29801477
Empyema	15.83	11.60	37	130120	2819	29819502
Eating disorder	15.77	11.60	5	130152	6822	29815499
Mucocutaneous haemorrhage	15.74	11.60	8	130149	92	29822229
Ureteric compression	15.72	11.60	6	130151	32	29822289
Back pain	15.71	11.60	333	129824	102263	29720058
Ischaemic cardiomyopathy	15.67	11.60	4	130153	6293	29816028
Stiff person syndrome	15.62	11.60	9	130148	135	29822186
Impaired work ability	15.61	11.60	57	130100	5586	29816735
Myoclonus	15.57	11.60	21	130136	13291	29809030
Bacterial infection	15.57	11.60	101	130056	12509	29809812
Mantle cell lymphoma stage IV	15.55	11.60	7	130150	60	29822261
Respiratory tract infection	15.51	11.60	118	130039	15388	29806933
Lung adenocarcinoma	15.46	11.60	46	130111	4053	29818268
Bone disorder	15.46	11.60	5	130152	6736	29815585
Acute respiratory distress syndrome	15.43	11.60	163	129994	23309	29799012
Cutaneous T-cell lymphoma recurrent	15.42	11.60	6	130151	34	29822287
Gallbladder adenocarcinoma	15.35	11.60	5	130152	15	29822306
Coxsackie viral infection	15.35	11.60	5	130152	15	29822306
Hyperthyroidism	15.34	11.60	8	130149	8090	29814231
Ageusia	15.32	11.60	10	130147	8943	29813378
Retroperitoneal lymphadenopathy	15.32	11.60	17	130140	682	29821639
COVID-19 pneumonia	15.31	11.60	49	130108	4491	29817830
Lymphocyte count decreased	15.30	11.60	138	130019	18917	29803404
Visual impairment	15.30	11.60	74	130083	30364	29791957
Crystal nephropathy	15.30	11.60	13	130144	373	29821948
Acute myelomonocytic leukaemia	15.22	11.60	9	130148	142	29822179
Cardiotoxicity	15.21	11.60	48	130109	4366	29817955
Viral cardiomyopathy	15.14	11.60	6	130151	36	29822285
Dysstasia	15.11	11.60	14	130143	10491	29811830
Mydriasis	15.10	11.60	4	130153	6139	29816182
Blood creatinine increased	15.06	11.60	293	129864	91082	29731239
Neck pain	15.04	11.60	44	130113	20900	29801421
Malignant transformation	15.04	11.60	17	130140	696	29821625
Mental impairment	15.03	11.60	11	130146	9266	29813055
Positron emission tomogram abnormal	15.02	11.60	8	130149	102	29822219
Aplasia	14.94	11.60	45	130112	3992	29818329
Atypical fibroxanthoma	14.90	11.60	10	130147	199	29822122
Phlebitis infective	14.85	11.60	9	130148	149	29822172
Nasal congestion	14.84	11.60	37	130120	18529	29803792
Tooth infection	14.84	11.60	53	130104	5138	29817183
Pulmonary vasculitis	14.80	11.60	7	130150	68	29822253
Pulmonary congestion	14.77	11.60	19	130138	12268	29810053
Sudden death	14.76	11.60	28	130129	15464	29806857
Castleman's disease	14.74	11.60	6	130151	39	29822282
Metastases to muscle	14.73	11.60	10	130147	203	29822118
Prostate cancer	14.65	11.60	164	129993	23793	29798528
Anorectal varices	14.61	11.60	6	130151	40	29822281
Polymyositis	14.57	11.60	24	130133	1412	29820909
Urticaria	14.55	11.60	325	129832	54281	29768040
Central nervous system infection	14.54	11.60	14	130143	474	29821847
Haemorrhage	14.54	11.60	129	130028	45950	29776371
Metastases to retroperitoneum	14.52	11.60	10	130147	208	29822113
Cytomegalovirus colitis	14.50	11.60	32	130125	2347	29819974
Skin infection	14.49	11.60	59	130098	6085	29816236
Rheumatoid factor increased	14.47	11.60	14	130143	477	29821844
Full blood count decreased	14.46	11.60	29	130128	15688	29806633
Presyncope	14.46	11.60	30	130127	16026	29806295
Mood altered	14.41	11.60	9	130148	8241	29814080
Abdominal wall abscess	14.38	11.60	14	130143	481	29821840
Swollen tongue	14.26	11.60	22	130135	13170	29809151
Helicobacter sepsis	14.26	11.60	5	130152	20	29822301
Ecthyma	14.25	11.60	12	130145	340	29821981
Borrelia infection	14.24	11.60	6	130151	43	29822278
Iron deficiency anaemia	14.23	11.60	11	130146	9013	29813308
Nocardiosis	14.21	11.60	40	130117	3415	29818906
Altered state of consciousness	14.19	11.60	42	130115	19877	29802444
Cytokine storm	14.19	11.60	15	130142	569	29821752
Acute lymphocytic leukaemia recurrent	14.19	11.60	34	130123	2633	29819688
Follicle centre lymphoma, follicular grade I, II, III recurrent	14.13	11.60	4	130153	6	29822315
Suspected product quality issue	14.05	11.60	9	130148	165	29822156
Thinking abnormal	13.96	11.60	3	130154	5308	29817013
Sphingomonas paucimobilis infection	13.90	11.60	6	130151	46	29822275
Phlebitis	13.89	11.60	42	130115	3733	29818588
Glottis carcinoma	13.88	11.60	5	130152	22	29822299
Infective thrombosis	13.81	11.60	7	130150	80	29822241
Recurrent cancer	13.79	11.60	21	130136	1155	29821166
Blood loss anaemia	13.77	11.60	8	130149	7619	29814702
Chronic obstructive pulmonary disease	13.74	11.60	131	130026	45995	29776326
Right ventricular failure	13.72	11.60	9	130148	8027	29814294
Myeloid leukaemia	13.70	11.60	12	130145	359	29821962
Blood bilirubin increased	13.67	11.60	98	130059	36538	29785783
Multiple organ dysfunction syndrome	13.65	11.60	367	129790	63120	29759201
Blood triglycerides increased	13.65	11.60	25	130132	13992	29808329
Hepatitis B DNULL increased	13.64	11.60	14	130143	513	29821808
Dyslipidaemia	13.58	11.60	4	130153	5723	29816598
Lymphoplasmacytoid lymphoma/immunocytoma recurrent	13.41	11.60	4	130153	8	29822313
Pulmonary mass	13.41	11.60	87	130070	10775	29811546
Haematoma	13.38	11.60	56	130101	23897	29798424
Lacrimal duct neoplasm	13.37	11.60	5	130152	25	29822296
Viral myelitis	13.37	11.60	5	130152	25	29822296
Mantle cell lymphoma stage III	13.37	11.60	5	130152	25	29822296
Hypoglobulinaemia	13.33	11.60	3	130154	0	29822321
Human anti-mouse antibody positive	13.33	11.60	3	130154	0	29822321
Necrotising soft tissue infection	13.27	11.60	6	130151	52	29822269
Device occlusion	13.24	11.60	5	130152	6115	29816206
Intraocular pressure increased	13.24	11.60	3	130154	5117	29817204
Dialysis	13.22	11.60	17	130140	10979	29811342
Injection site erythema	13.19	11.60	25	130132	13809	29808512
Increased appetite	13.18	11.60	4	130153	5613	29816708
Dyspnoea exertional	13.11	11.60	95	130062	35335	29786986
Ureaplasma infection	13.03	11.60	9	130148	188	29822133
Colitis ulcerative	12.97	11.60	27	130130	14407	29807914
Tularaemia	12.96	11.60	7	130150	92	29822229
Central nervous system vasculitis	12.95	11.60	12	130145	387	29821934
Guillain-Barre syndrome	12.94	11.60	50	130107	5033	29817288
Gonococcal infection	12.90	11.60	5	130152	28	29822293
Cerebral toxoplasmosis	12.83	11.60	23	130134	1449	29820872
Hyperammonaemia	12.82	11.60	4	130153	5516	29816805
Bone marrow necrosis	12.81	11.60	8	130149	140	29822181
Photosensitivity reaction	12.81	11.60	79	130078	9615	29812706
Basophilia	12.80	11.60	4	130153	10	29822311
Lung adenocarcinoma stage I	12.80	11.60	4	130153	10	29822311
Back disorder	12.80	11.60	5	130152	5989	29816332
Cholelithiasis	12.77	11.60	45	130112	20180	29802141
Neutrophil percentage decreased	12.77	11.60	12	130145	394	29821927
Venoocclusive disease	12.70	11.60	32	130125	2558	29819763
Alveolitis	12.69	11.60	25	130132	1692	29820629
Blood bilirubin decreased	12.63	11.60	10	130147	259	29822062
Evans syndrome	12.60	11.60	10	130147	260	29822061
Choking	12.59	11.60	3	130154	4943	29817378
Hemianopia	12.58	11.60	15	130142	651	29821670
Chronic lymphocytic leukaemia stage 2	12.53	11.60	4	130153	11	29822310
Blood pressure increased	12.53	11.60	405	129752	71523	29750798
Lymph node palpable	12.48	11.60	5	130152	31	29822290
Metastases to spleen	12.48	11.60	11	130146	332	29821989
Drug eruption	12.45	11.60	37	130120	17489	29804832
Bronchopneumopathy	12.45	11.60	12	130145	407	29821914
Infected neoplasm	12.45	11.60	6	130151	61	29822260
Ventricular hypertrophy	12.37	11.60	3	130154	4884	29817437
Refractory cytopenia with multilineage dysplasia	12.33	11.60	8	130149	150	29822171
Heparin-induced thrombocytopenia	12.33	11.60	4	130153	5379	29816942
Staphylococcal sepsis	12.32	11.60	77	130080	9414	29812907
Diffuse large B-cell lymphoma stage III	12.28	11.60	6	130151	63	29822258
Musculoskeletal discomfort	12.27	11.60	6	130151	6294	29816027
Alopecia	12.27	11.60	133	130024	19142	29803179
Fungal infection	12.23	11.60	101	130056	13499	29808822
Pruritus	12.21	11.60	406	129751	117798	29704523
Left ventricular hypertrophy	12.20	11.60	6	130151	6272	29816049
Gynaecomastia	12.16	11.60	11	130146	8340	29813981
Drug level increased	12.16	11.60	40	130117	18314	29804007
Acute hepatitis B	12.15	11.60	7	130150	105	29822216
Nervous system neoplasm	12.15	11.60	8	130149	154	29822167
Drug level decreased	12.14	11.60	5	130152	5800	29816521
Leukaemic infiltration	12.12	11.60	6	130151	65	29822256
Cystitis haemorrhagic	12.12	11.60	47	130110	4740	29817581
X-ray abnormal	11.99	11.60	13	130144	508	29821813
Autoimmune neutropenia	11.94	11.60	10	130147	281	29822040
Squamous cell carcinoma of skin	11.94	11.60	74	130083	9021	29813300
Blood cholesterol increased	11.93	11.60	36	130121	16934	29805387
Schizophrenia	11.93	11.60	13	130144	9035	29813286
Adverse event	11.93	11.60	31	130126	15310	29807011
Myelitis transverse	11.93	11.60	18	130139	982	29821339
Meningoencephalitis viral	11.92	11.60	7	130150	109	29822212
Rebound effect	11.87	11.60	23	130134	1538	29820783
Neoplasm	11.86	11.60	42	130115	4054	29818267
Shock	11.83	11.60	55	130102	22804	29799517
Encephalitis autoimmune	11.82	11.60	12	130145	434	29821887
B-lymphocyte abnormalities	11.82	11.60	4	130153	14	29822307
Pollakiuria	11.79	11.60	36	130121	16870	29805451
Activated partial thromboplastin time prolonged	11.78	11.60	10	130147	7818	29814503
Myelofibrosis	11.77	11.60	23	130134	1548	29820773
Pneumonia respiratory syncytial viral	11.75	11.60	14	130143	607	29821714
Volvulus of small bowel	11.74	11.60	5	130152	37	29822284
Dermatitis acneiform	11.73	11.60	5	130152	5684	29816637
Foetal exposure during pregnancy	11.73	11.60	103	130054	36768	29785553
Aplasia pure red cell	11.70	11.60	52	130105	5574	29816747
Blood lactate dehydrogenase increased	11.69	11.60	139	130018	20462	29801859
Blood potassium increased	11.69	11.60	34	130123	16179	29806142
Haemoptysis	11.66	11.60	83	130074	30995	29791326
Hepatosplenomegaly	11.63	11.60	39	130118	3662	29818659
Phaeohyphomycosis	11.63	11.60	16	130141	802	29821519
Obesity	11.61	11.60	12	130145	8543	29813778
Reflux laryngitis	11.61	11.60	4	130153	15	29822306
Palmar-plantar erythrodysaesthesia syndrome	11.60	11.60	30	130127	14840	29807481

Pharmacologic Action:

Source	Code	Description
ATC	L01XC02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Monoclonal antibodies
FDA MoA	N0000175078	CD20-directed Antibody Interactions
FDA EPC	N0000175657	CD20-directed Cytolytic Antibody
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000074322	Antineoplastic Agents, Immunological
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D007155	Immunologic Factors

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Rheumatoid arthritis	indication	69896004	DOID:7148
Chronic lymphoid leukemia, disease	indication	92814006
Non-Hodgkin's lymphoma	indication	118601006
Wegener's granulomatosis	indication	195353004	DOID:12132
Microscopic polyarteritis nodosa	indication	239928004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
B-lymphocyte antigen CD20	Surface antigen	P11836	CD20_HUMAN	ANTIBODY BINDING	Kd	8.51		IUPHAR	DRUG LABEL

External reference:

ID	Source
D02994	KEGG_DRUG
4021104	VUID
N0000148560	NUI
4021104	VANDF
C1314901	UMLSCUI
CHEMBL1201576	ChEMBL_ID
D000069283	MESH_DESCRIPTOR_UI
6780	IUPHAR_LIGAND_ID
7609	INN_ID
DB00073	DRUGBANK_ID
4F4X42SYQ6	UNII
121191	RXNORM
11468	MMSL
5432	MMSL
d04255	MMSL
007236	NDDF
108809004	SNOMEDCT_US
386919002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ruxience	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0238	INJECTION, SOLUTION	100 mg	INTRAVENOUS	BLA	30 sections
Ruxience	HUMAN PRESCRIPTION DRUG LABEL	1	0069-0249	INJECTION, SOLUTION	500 mg	INTRAVENOUS	BLA	30 sections
Rituxan	HUMAN PRESCRIPTION DRUG LABEL	1	50242-051	INJECTION, SOLUTION	10 mg	INTRAVENOUS	BLA	32 sections
Rituxan	HUMAN PRESCRIPTION DRUG LABEL	1	50242-053	INJECTION, SOLUTION	10 mg	INTRAVENOUS	BLA	32 sections
Rituxan Hycela	HUMAN PRESCRIPTION DRUG LABEL	2	50242-108	INJECTION, SOLUTION	120 mg	SUBCUTANEOUS	BLA	28 sections
Rituxan Hycela	HUMAN PRESCRIPTION DRUG LABEL	2	50242-109	INJECTION, SOLUTION	120 mg	SUBCUTANEOUS	BLA	28 sections
Riabni	HUMAN PRESCRIPTION DRUG LABEL	1	55513-224	INJECTION, SOLUTION	100 mg	INTRAVENOUS	BLA	31 sections
Riabni	HUMAN PRESCRIPTION DRUG LABEL	1	55513-326	INJECTION, SOLUTION	500 mg	INTRAVENOUS	BLA	31 sections
Truxima	HUMAN PRESCRIPTION DRUG LABEL	1	63459-103	INJECTION, SOLUTION	10 mg	INTRAVENOUS	BLA	29 sections
Truxima	HUMAN PRESCRIPTION DRUG LABEL	1	63459-104	INJECTION, SOLUTION	10 mg	INTRAVENOUS	BLA	29 sections