rituximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4975 174722-31-7

Description:

MoleculeDescription

Synonyms:

  • rituximab
  • rituxan
  • MabThera
  • rituximab (genetical recombination)
A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 25, 2008 PMDA Bayer Yakuhin, Nihon Schering, Zenyaku Kogyo
Nov. 26, 1997 FDA GENENTECH
June 2, 1998 EMA Roche Registration GmbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 3516.67 10.98 18921 775116 1083331 88751079
Contraindicated product administered 2340.53 10.98 7132 786905 313007 89521403
Drug intolerance 1822.17 10.98 8254 785783 439337 89395073
Infusion related reaction 1817.67 10.98 7846 786191 408934 89425476
Treatment failure 1815.57 10.98 6322 787715 297606 89536804
Pemphigus 1809.21 10.98 6631 787406 320233 89514177
Systemic lupus erythematosus 1710.12 10.98 6983 787054 354913 89479497
Glossodynia 1522.88 10.98 6213 787824 315566 89518844
Drug ineffective 1518.84 10.98 18623 775414 1365675 88468735
Synovitis 1486.86 10.98 6273 787764 323479 89510931
Hand deformity 1411.41 10.98 5734 788303 290628 89543782
Product dose omission issue 1398.26 10.98 410 793627 291277 89543133
Arthropathy 1342.60 10.98 6554 787483 359688 89474722
Drug interaction 1331.67 10.98 385 793652 276068 89558342
No adverse event 1323.16 10.98 2239 791798 65743 89768667
Completed suicide 1218.37 10.98 9 794028 145049 89689361
Joint swelling 1209.53 10.98 8044 785993 495256 89339154
Toxicity to various agents 1112.65 10.98 566 793471 287280 89547130
Intentional product use issue 1056.14 10.98 4227 789810 212665 89621745
Wound 1055.73 10.98 5346 788691 297634 89536776
Alopecia 1001.03 10.98 7590 786447 487481 89346929
Injection site pain 978.20 10.98 171 793866 173528 89660882
Swelling 977.88 10.98 6651 787386 412407 89422003
Therapeutic product effect decreased 977.65 10.98 4913 789124 272658 89561752
Anti-cyclic citrullinated peptide antibody positive 971.50 10.98 4376 789661 232057 89602353
Abdominal discomfort 914.78 10.98 7228 786809 470100 89364310
Hepatic enzyme increased 900.28 10.98 5823 788214 354913 89479497
Pericarditis 883.44 10.98 4684 789353 265467 89568943
Acute kidney injury 789.47 10.98 988 793049 319399 89515011
Intentional overdose 787.02 10.98 6 794031 93828 89740582
Rheumatoid factor positive 777.33 10.98 3272 790765 168378 89666032
Drug effective for unapproved indication 744.65 10.98 591 793446 7327 89827083
Progressive multifocal leukoencephalopathy 739.40 10.98 795 793242 14860 89819550
Hypogammaglobulinaemia 739.09 10.98 668 793369 10006 89824404
Diffuse large B-cell lymphoma recurrent 733.30 10.98 430 793607 3096 89831314
Fall 731.96 10.98 1998 792039 479812 89354598
Diarrhoea 708.72 10.98 5072 788965 934118 88900292
Constipation 706.17 10.98 850 793187 279545 89554865
Drug abuse 691.94 10.98 5 794032 82342 89752068
Helicobacter infection 660.89 10.98 3813 790224 223037 89611373
Product use issue 653.26 10.98 5036 789001 324883 89509527
Duodenal ulcer perforation 645.61 10.98 3721 790316 217567 89616843
Dehydration 611.49 10.98 484 793553 193963 89640447
Discomfort 604.64 10.98 4296 789741 270039 89564371
Infection 594.24 10.98 5298 788739 356796 89477614
Hypersensitivity 576.52 10.98 6304 787733 448373 89386037
Nausea 544.86 10.98 6675 787362 1103641 88730769
Feeling abnormal 527.40 10.98 415 793622 166820 89667590
Suicide attempt 525.98 10.98 34 794003 75365 89759045
Injection site erythema 524.73 10.98 111 793926 98391 89736019
Drug hypersensitivity 515.65 10.98 6267 787770 457342 89377068
Ill-defined disorder 508.15 10.98 3061 790976 181830 89652580
Musculoskeletal stiffness 506.63 10.98 4378 789659 292154 89542256
Somnolence 504.11 10.98 655 793382 208429 89625981
Throat irritation 485.70 10.98 1217 792820 47478 89786932
Hyponatraemia 473.18 10.98 292 793745 133246 89701164
Maternal exposure during pregnancy 467.96 10.98 5018 789019 355045 89479365
Myalgia 455.60 10.98 517 793520 174608 89659802
Folliculitis 453.41 10.98 3206 790831 201147 89633263
Seizure 451.43 10.98 403 793634 152226 89682184
Dizziness 430.82 10.98 3208 790829 586076 89248334
Depressed level of consciousness 426.77 10.98 64 793973 72720 89761690
Suicidal ideation 400.05 10.98 80 793957 73775 89760635
Anaemia 396.61 10.98 1666 792371 351136 89483274
Wrong technique in product usage process 390.87 10.98 76 793961 71495 89762915
Muscle injury 390.38 10.98 2769 791268 173885 89660525
Vision blurred 389.59 10.98 242 793795 110051 89724359
Ear pruritus 389.17 10.98 383 793654 6420 89827990
Hypotension 388.18 10.98 1501 792536 323896 89510514
Cardiac failure congestive 387.07 10.98 190 793847 98504 89735906
Tremor 384.65 10.98 465 793572 152708 89681702
Rhabdomyolysis 383.21 10.98 15 794022 51241 89783169
Dry skin 382.82 10.98 146 793891 87927 89746483
Electrocardiogram QT prolonged 381.12 10.98 84 793953 72372 89762038
Red blood cell sedimentation rate increased 377.11 10.98 1579 792458 81016 89753394
Haematochezia 375.46 10.98 81 793956 70832 89763578
Rheumatic fever 375.13 10.98 2462 791575 150659 89683751
Hypoglycaemia 373.47 10.98 78 793959 69770 89764640
Death 371.06 10.98 2409 791628 454142 89380268
Pain 369.53 10.98 11373 782664 984968 88849442
Incorrect dose administered 352.92 10.98 125 793912 78805 89755605
Irritable bowel syndrome 352.56 10.98 3060 790977 204388 89630022
C-reactive protein abnormal 352.06 10.98 2113 791924 125316 89709094
Urinary tract infection 349.82 10.98 1433 792604 304199 89530211
Inflammation 343.99 10.98 2710 791327 175882 89658528
Injection site swelling 336.53 10.98 59 793978 59780 89774630
Psoriatic arthropathy 332.94 10.98 3259 790778 225076 89609334
Type 2 diabetes mellitus 332.45 10.98 2973 791064 200271 89634139
Cardiac arrest 331.27 10.98 260 793777 104675 89729735
Bradycardia 324.91 10.98 164 793873 83683 89750727
Back pain 322.63 10.98 1554 792483 315621 89518789
Therapy interrupted 320.72 10.98 33 794004 50075 89784335
Sedation 315.49 10.98 29 794008 48142 89786268
COVID-19 pneumonia 313.63 10.98 568 793469 17609 89816801
Hallucination 311.52 10.98 95 793942 65864 89768546
Sleep disorder due to general medical condition, insomnia type 310.18 10.98 2061 791976 126633 89707777
Cardio-respiratory arrest 309.13 10.98 85 793952 63055 89771355
Blood cholesterol increased 308.66 10.98 2980 791057 205032 89629378
Injection site pruritus 307.33 10.98 51 793986 53783 89780627
Blood pressure fluctuation 306.50 10.98 1084 792953 51329 89783081
Agitation 302.16 10.98 105 793932 66993 89767417
Blood pressure diastolic abnormal 301.66 10.98 588 793449 19293 89815117
Hepatitis B reactivation 301.62 10.98 262 793775 3712 89830698
International normalised ratio increased 300.68 10.98 32 794005 47284 89787126
Disease progression 295.80 10.98 2366 791671 154249 89680161
C-reactive protein increased 293.89 10.98 2648 791389 178741 89655669
Swollen joint count increased 293.88 10.98 1823 792214 109383 89725027
Impaired healing 293.75 10.98 3242 790795 230957 89603453
Blood pressure systolic abnormal 286.96 10.98 569 793468 18909 89815501
Metabolic acidosis 283.96 10.98 69 793968 55607 89778803
Accidental exposure to product 270.90 10.98 28 794009 42338 89792072
Oedema peripheral 266.69 10.98 1256 792781 256659 89577751
Swelling face 262.60 10.98 197 793840 81155 89753255
Pulmonary fibrosis 261.68 10.98 1726 792311 105777 89728633
Coma 256.99 10.98 159 793878 72473 89761937
Mobility decreased 255.31 10.98 3336 790701 247398 89587012
Hyperkalaemia 254.82 10.98 125 793912 64839 89769571
Myocardial infarction 251.17 10.98 336 793701 105636 89728774
Liver injury 250.24 10.98 2438 791599 168129 89666281
Dyspnoea 246.98 10.98 5858 788179 875097 88959313
Balance disorder 246.57 10.98 292 793745 96788 89737622
Gastrointestinal haemorrhage 245.05 10.98 257 793780 89991 89744419
Lactic acidosis 245.05 10.98 69 793968 50394 89784016
Overdose 242.66 10.98 649 793388 157060 89677350
Rheumatoid nodule 241.18 10.98 541 793496 19625 89814785
Surgery 240.23 10.98 50 793987 44837 89789573
Blood glucose increased 239.23 10.98 289 793748 94957 89739453
Serum sickness 238.03 10.98 218 793819 3324 89831086
Lower respiratory tract infection 236.67 10.98 3290 790747 247369 89587041
Blister 235.95 10.98 3335 790702 251663 89582747
Intentional self-injury 232.35 10.98 5 794032 29329 89805081
Drug withdrawal syndrome 231.13 10.98 4 794033 28719 89805691
Abdominal pain 230.24 10.98 2285 791752 393436 89440974
Flatulence 229.98 10.98 42 793995 41325 89793085
Anxiety 229.40 10.98 1679 792358 308093 89526317
Orthostatic hypotension 227.16 10.98 45 793992 41782 89792628
Fibromyalgia 226.36 10.98 2783 791254 203486 89630924
Plasma cell myeloma 225.81 10.98 42 793995 40786 89793624
Vertigo 225.39 10.98 169 793868 69642 89764768
Febrile neutropenia 223.34 10.98 2245 791792 156104 89678306
Hospitalisation 223.20 10.98 494 793543 127606 89706804
Macular degeneration 221.18 10.98 34 794003 37936 89796474
Renal failure 220.32 10.98 515 793522 130492 89703918
Therapy cessation 220.13 10.98 29 794008 36332 89798078
Device issue 219.60 10.98 9 794028 29528 89804882
Serotonin syndrome 218.26 10.98 35 794002 37852 89796558
Rash 215.42 10.98 8770 785267 787330 89047080
Coeliac disease 214.75 10.98 867 793170 43743 89790667
Bursitis 214.73 10.98 1925 792112 129729 89704681
B-lymphocyte count decreased 214.21 10.98 143 793894 1326 89833084
Cytomegalovirus infection 213.91 10.98 614 793423 25988 89808422
Epistaxis 211.98 10.98 260 793777 84865 89749545
Unresponsive to stimuli 211.30 10.98 39 793998 38082 89796328
Injection site bruising 210.75 10.98 97 793940 52210 89782200
Vomiting 209.79 10.98 5282 788755 783011 89051399
Stomatitis 204.13 10.98 3462 790575 271236 89563174
Respiratory arrest 203.03 10.98 26 794011 33285 89801125
Immunodeficiency 201.58 10.98 832 793205 42402 89792008
Joint range of motion decreased 201.46 10.98 1944 792093 133699 89700711
Dyskinesia 201.16 10.98 38 793999 36496 89797914
Facet joint syndrome 201.01 10.98 1514 792523 96875 89737535
Lip dry 200.94 10.98 1544 792493 99411 89734999
Cognitive disorder 198.35 10.98 189 793848 69218 89765192
Full blood count abnormal 197.44 10.98 40 793997 36557 89797853
Dysgeusia 197.42 10.98 107 793930 52453 89781957
Gastrointestinal disorder 196.95 10.98 3252 790785 253435 89580975
Hypokalaemia 196.87 10.98 546 793491 130570 89703840
Cerebrovascular accident 194.10 10.98 503 793534 123030 89711380
Chronic obstructive pulmonary disease 190.78 10.98 219 793818 73610 89760800
Therapy non-responder 189.82 10.98 1932 792105 134772 89699638
Grip strength decreased 189.38 10.98 1425 792612 91151 89743259
Vaccination failure 188.83 10.98 123 793914 1090 89833320
Pneumocystis jirovecii pneumonia 188.65 10.98 514 793523 21102 89813308
Multiple sclerosis relapse 188.54 10.98 112 793925 52193 89782217
Lethargy 187.47 10.98 166 793871 62973 89771437
Diffuse large B-cell lymphoma refractory 185.85 10.98 142 793895 1658 89832752
Eczema 185.30 10.98 117 793920 52753 89781657
Tachycardia 184.81 10.98 732 793305 156941 89677469
Injection site rash 184.43 10.98 6 794031 24167 89810243
Emotional distress 183.93 10.98 47 793990 36615 89797795
Prescribed overdose 183.24 10.98 1473 792564 96152 89738258
Injection site haemorrhage 182.92 10.98 18 794019 28300 89806110
Disturbance in attention 182.71 10.98 92 793945 47017 89787393
Sopor 181.58 10.98 8 794029 24636 89809774
Panniculitis 180.94 10.98 395 793642 14063 89820347
Injury 180.86 10.98 2577 791460 194772 89639638
Angioedema 179.24 10.98 182 793855 64694 89769716
Disorientation 178.98 10.98 81 793956 44033 89790377
COVID-19 178.73 10.98 2263 791774 166580 89667830
Blood potassium decreased 176.59 10.98 99 793938 47628 89786782
Neuropathy peripheral 176.16 10.98 612 793425 136358 89698052
Asthenia 175.90 10.98 3457 790580 530294 89304116
Blood calcium decreased 175.87 10.98 27 794010 30155 89804255
Blood pressure systolic increased 174.37 10.98 988 793049 57357 89777053
Generalised tonic-clonic seizure 172.71 10.98 46 793991 34857 89799553
Syncope 171.12 10.98 592 793445 132071 89702339
Palmar-plantar erythrodysaesthesia syndrome 170.48 10.98 22 794015 28001 89806409
Tumour lysis syndrome 169.39 10.98 330 793707 10822 89823588
Humoral immune defect 167.51 10.98 78 793959 322 89834088
Blood bilirubin increased 166.94 10.98 86 793951 43384 89791026
Cellulitis 165.95 10.98 344 793693 90993 89743417
Mental status changes 163.41 10.98 94 793943 44585 89789825
Osteonecrosis of jaw 163.08 10.98 69 793968 39034 89795376
Blood parathyroid hormone decreased 162.37 10.98 342 793695 11874 89822536
Hip arthroplasty 162.09 10.98 1184 792853 75024 89759386
Swollen tongue 162.02 10.98 101 793936 45855 89788555
Irritability 161.95 10.98 55 793982 35607 89798803
Urinary retention 161.63 10.98 64 793973 37680 89796730
Granuloma skin 160.96 10.98 315 793722 10365 89824045
Accidental overdose 160.90 10.98 27 794010 28246 89806164
Device dislocation 160.57 10.98 39 793998 31443 89802967
Injection site mass 160.07 10.98 8 794029 22082 89812328
Lung disorder 159.10 10.98 2010 792027 147873 89686537
Haemoglobin decreased 159.04 10.98 803 793234 161153 89673257
Palpitations 156.93 10.98 640 793397 136088 89698322
Loss of consciousness 156.25 10.98 664 793373 139574 89694836
Drug tolerance decreased 155.88 10.98 626 793411 31504 89802906
Post transplant lymphoproliferative disorder 154.24 10.98 243 793794 6706 89827704
Unevaluable event 153.66 10.98 152 793885 54696 89779714
Lip swelling 153.39 10.98 73 793964 38537 89795873
General physical health deterioration 152.57 10.98 4133 789904 350982 89483428
Hyperglycaemia 152.54 10.98 133 793904 50837 89783573
Nightmare 150.90 10.98 10 794027 21715 89812695
Peripheral venous disease 150.36 10.98 1253 792784 82668 89751742
Haematemesis 149.75 10.98 54 793983 33672 89800738
Cholelithiasis 148.84 10.98 144 793893 52362 89782048
Transient ischaemic attack 147.97 10.98 98 793939 43078 89791332
Sciatica 147.57 10.98 1447 792590 99935 89734475
Full blood count decreased 147.14 10.98 39 793998 29650 89804760
Hypophagia 145.78 10.98 66 793971 35871 89798539
Arthralgia 145.76 10.98 8272 785765 770250 89064160
Hypoxia 145.22 10.98 257 793780 72142 89762268
Hepatitis B 144.47 10.98 188 793849 4331 89830079
Metastases to bone 143.73 10.98 25 794012 25480 89808930
Wound infection 143.52 10.98 1495 792542 104907 89729503
Wheezing 143.21 10.98 2904 791133 235176 89599234
Headache 143.04 10.98 6143 787894 856603 88977807
Oedema 141.38 10.98 2504 791533 197791 89636619
Speech disorder 141.27 10.98 115 793922 45470 89788940
Withdrawal syndrome 141.17 10.98 16 794021 22508 89811902
Hypomagnesaemia 140.29 10.98 68 793969 35520 89798890
Abortion spontaneous 140.04 10.98 160 793877 53896 89780514
Depressed mood 139.75 10.98 140 793897 50082 89784328
Creatinine renal clearance decreased 139.69 10.98 6 794031 18893 89815517
Restlessness 139.67 10.98 69 793968 35651 89798759
Sleep disorder 139.53 10.98 2475 791562 195555 89638855
Malignant neoplasm progression 138.43 10.98 476 793561 106394 89728016
Pulmonary embolism 138.11 10.98 632 793405 130188 89704222
Illness 137.97 10.98 322 793715 81647 89752763
Bone erosion 137.40 10.98 865 793172 52156 89782254
Procedural pain 137.31 10.98 60 793977 33300 89801110
Chronic kidney disease 137.29 10.98 142 793895 50049 89784361
Lymphoma 136.88 10.98 341 793696 13250 89821160
Osteoarthritis 136.40 10.98 2442 791595 193288 89641122
Device malfunction 136.37 10.98 13 794024 20964 89813446
Product substitution issue 135.53 10.98 5 794032 18003 89816407
Device difficult to use 134.97 10.98 4 794033 17521 89816889
Drug level increased 134.72 10.98 38 793999 27724 89806686
Disease recurrence 134.67 10.98 670 793367 36983 89797427
Metastases to liver 133.32 10.98 43 793994 28764 89805646
Diabetic ketoacidosis 133.08 10.98 26 794011 24381 89810029
Abnormal behaviour 132.40 10.98 20 794017 22608 89811802
Obstructive airways disorder 132.03 10.98 32 794005 25837 89808573
Impaired quality of life 131.93 10.98 22 794015 23122 89811288
Inappropriate schedule of product administration 131.45 10.98 772 793265 149161 89685249
Pulmonary oedema 131.29 10.98 213 793824 61867 89772543
Pulmonary hypertension 130.87 10.98 108 793929 42415 89791995
Skin exfoliation 130.05 10.98 248 793789 67665 89766745
Musculoskeletal pain 129.56 10.98 2165 791872 169086 89665324
Injection site urticaria 129.01 10.98 7 794030 18004 89816406
Blood creatine phosphokinase increased 128.16 10.98 69 793968 33954 89800456
Nail disorder 128.08 10.98 922 793115 58145 89776265
Blood pressure diastolic decreased 128.02 10.98 520 793517 26306 89808104
Hallucination, auditory 125.45 10.98 3 794034 15972 89818438
Cytopenia 125.35 10.98 387 793650 17062 89817348
JC virus infection 124.75 10.98 136 793901 2583 89831827
Loss of personal independence in daily activities 124.13 10.98 1776 792261 134329 89700081
Head injury 123.84 10.98 59 793978 31129 89803281
Demyelination 123.79 10.98 241 793796 7899 89826511
Dyspnoea exertional 123.26 10.98 282 793755 72006 89762404
Cytokine release syndrome 122.37 10.98 528 793509 27445 89806965
Female genital tract fistula 121.86 10.98 9 794028 17859 89816551
Nasopharyngitis 121.74 10.98 4536 789501 402568 89431842
Rectal haemorrhage 120.91 10.98 349 793688 82395 89752015
Product label confusion 120.44 10.98 457 793580 22393 89812017
Breast cancer stage III 119.84 10.98 1199 792838 83248 89751162
Poisoning 118.95 10.98 3 794034 15214 89819196
Coronary artery disease 118.39 10.98 74 793963 33549 89800861
Product dose omission in error 117.97 10.98 19 794018 20484 89813926
Product administration error 117.84 10.98 42 793995 26381 89808029
Blood alkaline phosphatase increased 117.44 10.98 149 793888 47930 89786480
B-cell lymphoma recurrent 117.19 10.98 67 793970 457 89833953
Hallucination, visual 117.00 10.98 29 794008 23063 89811347
Drug reaction with eosinophilia and systemic symptoms 116.92 10.98 121 793916 42637 89791773
Blood sodium decreased 116.32 10.98 48 793989 27565 89806845
Blood pressure decreased 116.07 10.98 307 793730 74588 89759822
Proctitis 115.67 10.98 4 794033 15255 89819155
Knee arthroplasty 115.62 10.98 1176 792861 82006 89752404
Gait inability 115.01 10.98 1863 792174 144593 89689817
Skin discolouration 114.98 10.98 131 793906 44184 89790226
Extrapyramidal disorder 114.74 10.98 7 794030 16296 89818114
Aggression 114.55 10.98 45 793992 26623 89807787
Caesarean section 114.43 10.98 14 794023 18563 89815847
Foetal exposure during pregnancy 113.73 10.98 125 793912 42850 89791560
Urinary incontinence 113.66 10.98 97 793940 37469 89796941
Altered state of consciousness 112.97 10.98 68 793969 31464 89802946
Condition aggravated 112.86 10.98 6336 787701 589209 89245201
Skin necrosis 112.79 10.98 366 793671 16575 89817835
Nasal oedema 112.64 10.98 205 793832 6379 89828031
Back injury 111.86 10.98 746 793291 45876 89788534
Product storage error 111.55 10.98 21 794016 20220 89814190
Labelled drug-drug interaction medication error 109.91 10.98 4 794033 14578 89819832
Therapeutic response unexpected 109.85 10.98 28 794009 21852 89812558
Haematoma 109.63 10.98 108 793929 38940 89795470
Pleural effusion 109.50 10.98 556 793481 111435 89722975
Burning sensation 109.43 10.98 246 793791 63206 89771204
Schizophrenia 109.36 10.98 5 794032 14909 89819501
Pharyngeal paraesthesia 109.28 10.98 137 793900 3037 89831373
Melaena 108.81 10.98 87 793950 34710 89799700
Eye pain 108.80 10.98 136 793901 44032 89790378
Pulmonary arterial hypertension 107.94 10.98 47 793990 26140 89808270
Hypersomnia 107.25 10.98 28 794009 21503 89812907
Pneumonia aspiration 106.24 10.98 121 793916 40819 89793591
Myelodysplastic syndrome 105.21 10.98 412 793625 20491 89813919
Therapy partial responder 104.96 10.98 427 793610 21616 89812794
Dysuria 104.94 10.98 114 793923 39287 89795123
Finger deformity 104.92 10.98 567 793470 32330 89802080
Pallor 104.86 10.98 87 793950 34078 89800332
Cardiac failure 104.59 10.98 548 793489 108948 89725462
Temperature regulation disorder 103.48 10.98 322 793715 14257 89820153
Toxic epidermal necrolysis 103.38 10.98 80 793957 32448 89801962
Pollakiuria 102.60 10.98 83 793954 32922 89801488
X-ray abnormal 102.54 10.98 716 793321 44708 89789702
Weight decreased 101.66 10.98 2542 791495 377368 89457042
Cytomegalovirus viraemia 101.54 10.98 213 793824 7373 89827037
Musculoskeletal deformity 101.46 10.98 103 793934 1795 89832615
Drug ineffective for unapproved indication 101.31 10.98 960 793077 65684 89768726
Sleep apnoea syndrome 101.00 10.98 78 793959 31669 89802741
Cytomegalovirus infection reactivation 100.92 10.98 216 793821 7584 89826826
Tinnitus 100.75 10.98 138 793899 42964 89791446
Abdominal pain lower 100.07 10.98 71 793966 30106 89804304
Chronic lymphocytic leukaemia recurrent 100.07 10.98 55 793982 344 89834066
Myoclonus 99.23 10.98 23 794014 19145 89815265
Parkinsonism 99.11 10.98 6 794031 14059 89820351
Cardiac disorder 98.47 10.98 220 793817 56652 89777758
Ulcer 98.36 10.98 557 793480 32325 89802085
Needle issue 98.01 10.98 6 794031 13928 89820482
Nasal congestion 97.87 10.98 387 793650 83027 89751383
Decreased appetite 97.65 10.98 2531 791506 374009 89460401
Jaundice 97.12 10.98 85 793952 32432 89801978
Hepatic function abnormal 96.78 10.98 160 793877 46128 89788282
Obesity 96.69 10.98 1378 792659 104129 89730281
Visual acuity reduced 96.52 10.98 42 793995 23368 89811042
Hypervolaemia 96.18 10.98 87 793950 32670 89801740
Dystonia 95.85 10.98 16 794021 16803 89817607
Acute myocardial infarction 95.10 10.98 99 793938 34791 89799619
Injection site warmth 94.78 10.98 19 794018 17496 89816914
Foot deformity 94.55 10.98 867 793170 58784 89775626
Dysphonia 93.70 10.98 264 793773 62820 89771590
Complication associated with device 93.67 10.98 27 794010 19422 89814988
Sinus tachycardia 92.06 10.98 69 793968 28444 89805966
Contrast media allergy 92.06 10.98 124 793913 2957 89831453
Vaginal haemorrhage 91.88 10.98 83 793954 31188 89803222
Haematocrit decreased 91.81 10.98 140 793897 41692 89792718
Panic attack 91.49 10.98 59 793978 26306 89808104
Rhinitis allergic 91.26 10.98 18 794019 16767 89817643
Deformity 91.24 10.98 274 793763 11896 89822514
Hypercholesterolaemia 90.97 10.98 1314 792723 99578 89734832
Ureaplasma infection 90.39 10.98 70 793967 835 89833575
Gamma-glutamyltransferase increased 90.24 10.98 120 793917 37832 89796578
Eye pruritus 90.23 10.98 73 793964 28954 89805456
Stevens-Johnson syndrome 89.92 10.98 75 793962 29301 89805109
Pericardial effusion 89.08 10.98 115 793922 36718 89797692
Onychomycosis 89.03 10.98 597 793440 36779 89797631
Tubulointerstitial nephritis 88.92 10.98 56 793981 25287 89809123
Gastritis 88.53 10.98 143 793894 41610 89792800
Vaginal discharge 88.41 10.98 30 794007 19434 89814976
Secondary immunodeficiency 88.37 10.98 101 793936 2025 89832385
Diffuse large B-cell lymphoma 88.22 10.98 218 793819 8427 89825983
Elbow deformity 88.17 10.98 86 793951 1425 89832985
Rash papular 88.00 10.98 34 794003 20321 89814089
Deep vein thrombosis 87.80 10.98 458 793579 91162 89743248
Mental disorder 87.75 10.98 92 793945 32226 89802184
Femur fracture 87.60 10.98 169 793868 45913 89788497
Circulatory collapse 87.42 10.98 55 793982 24849 89809561
Epstein-Barr virus infection 87.31 10.98 243 793794 10101 89824309
Haematotoxicity 87.26 10.98 275 793762 12260 89822150
Peripheral swelling 87.12 10.98 4440 789597 408666 89425744
Psychotic disorder 86.96 10.98 87 793950 31143 89803267
Atrial fibrillation 86.82 10.98 750 793287 132861 89701549
Faeces discoloured 86.72 10.98 39 793998 21281 89813129
Intestinal obstruction 86.67 10.98 119 793918 37012 89797398
Ocular hyperaemia 86.50 10.98 101 793936 33697 89800713
Bronchitis 86.30 10.98 889 793148 152038 89682372
Cardiomegaly 86.26 10.98 29 794008 18896 89815514
SLE arthritis 86.23 10.98 62 793975 655 89833755
Hypertension 86.04 10.98 4865 789172 452667 89381743
Hypothyroidism 86.00 10.98 213 793824 52914 89781496
Pancreatitis acute 85.44 10.98 93 793944 32022 89802388
Ventricular tachycardia 84.78 10.98 56 793981 24652 89809758
Transfusion 84.74 10.98 24 794013 17464 89816946
Eye irritation 84.35 10.98 104 793933 33874 89800536
Dermatitis contact 84.35 10.98 10 794027 13585 89820825
Hyperlipidaemia 84.10 10.98 48 793989 22868 89811542
Respiratory depression 84.06 10.98 17 794020 15558 89818852
Aspergillus infection 83.35 10.98 246 793791 10577 89823833
Blood urea increased 83.23 10.98 86 793951 30327 89804083
Product administration interrupted 83.21 10.98 7 794030 12485 89821925
Right ventricular failure 83.16 10.98 32 794005 19173 89815237
Night sweats 82.86 10.98 1587 792450 127179 89707231
Nervousness 82.70 10.98 106 793931 33950 89800460
Skin irritation 81.98 10.98 11 794026 13592 89820818
Polyomavirus-associated nephropathy 81.81 10.98 105 793932 2385 89832025
Anaphylactic shock 81.44 10.98 94 793943 31523 89802887
Rash macular 81.32 10.98 87 793950 30193 89804217
Red blood cell sedimentation rate 80.92 10.98 146 793891 4512 89829898
Deep vein thrombosis postoperative 80.90 10.98 963 793074 69846 89764564
Adjustment disorder with depressed mood 80.61 10.98 806 793231 55947 89778463
Onychomadesis 80.37 10.98 683 793354 45315 89789095
Obliterative bronchiolitis 80.26 10.98 108 793929 2573 89831837
Chronic sinusitis 80.25 10.98 55 793982 23747 89810663
Mantle cell lymphoma recurrent 80.25 10.98 48 793989 360 89834050
Ascites 79.96 10.98 188 793849 47552 89786858
Smooth muscle cell neoplasm 79.84 10.98 78 793959 1295 89833115
Metastases to central nervous system 79.75 10.98 27 794010 17515 89816895
Blood potassium increased 79.74 10.98 41 793996 20708 89813702
Coagulopathy 79.61 10.98 53 793984 23236 89811174
Blood immunoglobulin G decreased 78.91 10.98 124 793913 3414 89830996
Lymphoma transformation 78.89 10.98 39 793998 189 89834221
Therapeutic response decreased 78.68 10.98 1163 792874 88566 89745844
Anuria 78.27 10.98 17 794020 14801 89819609
Hip fracture 78.22 10.98 105 793932 32972 89801438
Complication of device insertion 78.19 10.98 3 794034 10433 89823977
Poor quality sleep 78.14 10.98 61 793976 24632 89809778
Staphylococcal bacteraemia 77.97 10.98 190 793847 7279 89827131
Stress 77.93 10.98 407 793630 80988 89753422
Mood altered 76.88 10.98 27 794010 17117 89817293
Radiculopathy 76.61 10.98 33 794004 18472 89815938
Depression 76.46 10.98 2026 792011 298575 89535835
Pelvic pain 76.43 10.98 20 794017 15337 89819073
Chest discomfort 76.18 10.98 809 793228 137556 89696854
Liver function test increased 76.05 10.98 1104 792933 83751 89750659
Mitral valve incompetence 76.00 10.98 52 793985 22472 89811938
Acute generalised exanthematous pustulosis 75.98 10.98 14 794023 13689 89820721
Basal cell carcinoma 75.77 10.98 527 793510 32862 89801548
Nasal polyps 75.59 10.98 5 794032 10875 89823535
Dementia 75.43 10.98 59 793978 23802 89810608
Dysstasia 75.41 10.98 65 793972 24987 89809423
Joint destruction 75.26 10.98 272 793765 13015 89821395
Chromaturia 75.11 10.98 37 794000 19150 89815260
Eye swelling 75.01 10.98 88 793949 29298 89805112
Upper gastrointestinal haemorrhage 74.96 10.98 55 793982 22921 89811489
Haemorrhoids 74.79 10.98 74 793963 26628 89807782
Mydriasis 73.87 10.98 20 794017 14992 89819418
Hot flush 73.66 10.98 270 793767 59218 89775192
Maternal exposure timing unspecified 73.39 10.98 390 793647 22093 89812317
Paraesthesia oral 73.36 10.98 102 793935 31557 89802853
Drug dose omission by device 73.21 10.98 4 794033 10227 89824183
Fear 73.14 10.98 27 794010 16595 89817815
Encephalopathy 73.01 10.98 189 793848 46255 89788155
Mania 73.01 10.98 17 794020 14107 89820303
Dislocation of vertebra 72.92 10.98 781 793256 55187 89779223
Blood glucose decreased 72.72 10.98 59 793978 23370 89811040
Food allergy 72.56 10.98 426 793611 25052 89809358
Liver disorder 72.45 10.98 1478 792559 119791 89714619
Muscle rigidity 72.44 10.98 18 794019 14291 89820119
Arthritis 72.21 10.98 1949 792088 165366 89669044
Insurance issue 70.68 10.98 7 794030 10951 89823459
Autoimmune disorder 70.57 10.98 1003 793034 75741 89758669
Hypokinesia 69.91 10.98 25 794012 15672 89818738
Rheumatoid arthritis 69.73 10.98 3864 790173 358750 89475660
Injection site induration 69.36 10.98 6 794031 10462 89823948
Product use in unapproved indication 69.25 10.98 3606 790431 332630 89501780
Lower limb fracture 69.19 10.98 1088 792949 83925 89750485
Delusion 68.93 10.98 18 794019 13822 89820588
Haemoptysis 68.89 10.98 116 793921 33204 89801206
Renal impairment 68.83 10.98 591 793446 104830 89729580
Haemorrhage 68.60 10.98 343 793694 69026 89765384
Muscle spasms 68.50 10.98 1681 792356 250202 89584208
Agranulocytosis 68.32 10.98 533 793504 34469 89799941
Adenovirus infection 68.05 10.98 135 793902 4487 89829923
C-reactive protein 67.63 10.98 489 793548 30878 89803532
Blood calcium increased 67.55 10.98 12 794025 12046 89822364
Colitis 67.37 10.98 349 793688 69593 89764817
Hyperhidrosis 67.17 10.98 817 793220 135488 89698922
Extra dose administered 67.05 10.98 3 794034 9115 89825295
Metastases to lung 67.03 10.98 28 794009 15963 89818447
Cholecystitis chronic 66.86 10.98 5 794032 9821 89824589
Adverse event 66.85 10.98 1421 792616 115997 89718413
Device breakage 66.72 10.98 20 794017 14024 89820386
Blood loss anaemia 66.68 10.98 6 794031 10134 89824276
Acidosis 66.49 10.98 15 794022 12721 89821689
Blood triglycerides increased 66.47 10.98 19 794018 13742 89820668
Electrolyte imbalance 66.28 10.98 66 793971 23679 89810731
Ageusia 66.03 10.98 29 794008 16047 89818363
Bipolar disorder 65.92 10.98 3 794034 8982 89825428
Breast cancer metastatic 65.88 10.98 25 794012 15107 89819303
Red blood cell sedimentation rate abnormal 65.29 10.98 399 793638 23805 89810605
Cerebral haemorrhage 65.28 10.98 127 793910 34395 89800015
Oral pruritus 65.23 10.98 103 793934 2848 89831562
Diplopia 65.05 10.98 94 793943 28620 89805790
Torsade de pointes 64.58 10.98 26 794011 15156 89819254
Erythema 64.51 10.98 1522 792515 227724 89606686
Intentional dose omission 64.20 10.98 38 793999 17745 89816665
Dry eye 64.06 10.98 275 793762 57656 89776754
Treatment noncompliance 63.90 10.98 235 793802 51492 89782918
Intentional product misuse 63.68 10.98 491 793546 89113 89745297
Genital haemorrhage 63.54 10.98 3 794034 8699 89825711
Oesophagitis 63.49 10.98 36 794001 17213 89817197
Blood immunoglobulin M decreased 63.39 10.98 69 793968 1308 89833102
Joint stiffness 63.21 10.98 998 793039 77044 89757366
Hospice care 63.12 10.98 6 794031 9698 89824712
Visual impairment 63.11 10.98 799 793238 131566 89702844
Cough 62.99 10.98 2617 791420 366345 89468065
Seasonal allergy 62.88 10.98 65 793972 22918 89811492
Device leakage 62.86 10.98 7 794030 9984 89824426
Hepatic cytolysis 62.66 10.98 109 793928 30807 89803603
Anger 62.58 10.98 21 794016 13699 89820711
Infusion site pain 62.15 10.98 49 793988 19689 89814721
Small intestinal obstruction 61.63 10.98 57 793980 21177 89813233
Eosinophil count increased 61.47 10.98 19 794018 13062 89821348
Flushing 61.44 10.98 488 793549 88003 89746407
Concomitant disease aggravated 61.28 10.98 13 794024 11505 89822905
Drug level decreased 60.76 10.98 7 794030 9723 89824687
Thrombosis 60.60 10.98 384 793653 72867 89761543
Sinus bradycardia 60.11 10.98 37 794000 16915 89817495
Diverticulum 59.86 10.98 16 794021 12097 89822313
Blood creatinine increased 59.84 10.98 583 793454 100803 89733607
Apathy 59.69 10.98 12 794025 11028 89823382
Surgical failure 59.53 10.98 57 793980 922 89833488
Sinusitis 59.45 10.98 3622 790415 339466 89494944
Live birth 59.38 10.98 999 793038 78108 89756302
Dry mouth 59.36 10.98 2069 791968 181990 89652420
Breast cancer female 59.35 10.98 28 794009 14858 89819552
Vascular access complication 58.64 10.98 88 793949 2325 89832085
Drug tolerance 58.63 10.98 311 793726 17605 89816805
Face oedema 58.27 10.98 71 793966 23247 89811163
Inappropriate antidiuretic hormone secretion 58.23 10.98 51 793986 19454 89814956
Hypocalcaemia 58.09 10.98 184 793853 42184 89792226
Haemophagocytic lymphohistiocytosis 58.08 10.98 279 793758 15180 89819230
Concussion 58.03 10.98 13 794024 11078 89823332
Haemodialysis 57.99 10.98 5 794032 8742 89825668
Cyanosis 57.92 10.98 51 793986 19404 89815006
Nocturia 57.90 10.98 10 794027 10245 89824165
Dizziness postural 57.83 10.98 6 794031 9047 89825363
White blood cell count decreased 57.73 10.98 1073 792964 166036 89668374
Cardiogenic shock 57.53 10.98 78 793959 24390 89810020
Eosinophilia 57.47 10.98 101 793936 28432 89805978
Sleep disorder due to a general medical condition 57.42 10.98 200 793837 44538 89789872
Initial insomnia 57.38 10.98 7 794030 9303 89825107
Prescribed underdose 57.27 10.98 950 793087 74069 89760341
Pain of skin 57.16 10.98 35 794002 16047 89818363
Acute respiratory failure 57.03 10.98 189 793848 42729 89791681
Influenza like illness 56.69 10.98 443 793594 80168 89754242
Red blood cell count decreased 56.32 10.98 212 793825 46139 89788271
Lipase increased 56.20 10.98 14 794023 11097 89823313
Major depression 56.19 10.98 10 794027 10025 89824385
Hepatitis E 56.09 10.98 76 793961 1823 89832587
Electrocardiogram abnormal 56.08 10.98 11 794026 10287 89824123
Product preparation error 55.80 10.98 11 794026 10250 89824160
Hyperthyroidism 55.73 10.98 47 793990 18263 89816147
Skin disorder 55.70 10.98 152 793885 36554 89797856
Immunoglobulins decreased 55.69 10.98 70 793967 1556 89832854
Electric shock 55.61 10.98 72 793965 1650 89832760
Skin burning sensation 55.33 10.98 54 793983 19557 89814853
Bone pain 54.91 10.98 318 793719 61665 89772745
Lupus vulgaris 54.67 10.98 620 793417 44439 89789971
Dysarthria 54.67 10.98 268 793769 54214 89780196
Prothrombin time prolonged 54.15 10.98 10 794027 9762 89824648
Hypomania 54.08 10.98 7 794030 8890 89825520
Central nervous system lymphoma 54.07 10.98 78 793959 1987 89832423
SARS-CoV-2 antibody test negative 53.93 10.98 35 794002 308 89834102
Hypothermia 53.84 10.98 35 794002 15540 89818870
Leukocytosis 53.55 10.98 120 793917 30870 89803540
Presyncope 53.46 10.98 125 793912 31680 89802730
Tenosynovitis 53.36 10.98 261 793776 14306 89820104
Fracture 53.31 10.98 69 793968 22007 89812403
Salivary hypersecretion 53.28 10.98 8 794029 9084 89825326
Renal disorder 52.91 10.98 163 793874 37696 89796714
Product complaint 52.90 10.98 26 794011 13474 89820936
Sensory disturbance 52.79 10.98 35 794002 15378 89819032
Gestational diabetes 52.25 10.98 14 794023 10568 89823842
Facial pain 52.24 10.98 25 794012 13157 89821253
Electrocardiogram QRS complex prolonged 52.18 10.98 3 794034 7345 89827065
Babesiosis 52.12 10.98 32 794005 253 89834157
Jaundice cholestatic 52.09 10.98 12 794025 10031 89824379
Therapy change 51.93 10.98 6 794031 8316 89826094
Red cell distribution width decreased 51.83 10.98 79 793958 2117 89832293
Lacrimation increased 51.65 10.98 99 793938 26963 89807447
Musculoskeletal chest pain 51.62 10.98 80 793957 23670 89810740
Subdural haematoma 51.56 10.98 42 793995 16603 89817807
Troponin increased 51.40 10.98 26 794011 13255 89821155
Colitis ischaemic 51.14 10.98 22 794015 12324 89822086
Atrioventricular block first degree 51.01 10.98 7 794030 8504 89825906
Tricuspid valve incompetence 50.86 10.98 43 793994 16688 89817722
Post procedural complication 50.81 10.98 55 793982 18987 89815423
Heavy menstrual bleeding 50.79 10.98 63 793974 20467 89813943
Ventricular fibrillation 50.71 10.98 30 794007 14014 89820396
Crying 50.55 10.98 92 793945 25553 89808857
Dialysis 50.53 10.98 18 794019 11311 89823099
Hyperbilirubinaemia 50.00 10.98 30 794007 13906 89820504
Neutropenia 49.97 10.98 2430 791607 222474 89611936
Transaminases increased 49.96 10.98 163 793874 37029 89797381
Spinal column injury 49.85 10.98 77 793960 2088 89832322
Middle insomnia 49.77 10.98 44 793993 16707 89817703
Varicella zoster virus infection 49.74 10.98 107 793930 3770 89830640
Hypoacusis 49.64 10.98 106 793931 27744 89806666
Pneumonia 49.41 10.98 6347 787690 631712 89202698
Muscle strain 49.40 10.98 12 794025 9675 89824735
Thirst 49.39 10.98 42 793995 16253 89818157
Gastrooesophageal reflux disease 49.13 10.98 1096 792941 165241 89669169
Sickle cell anaemia with crisis 48.85 10.98 4 794033 7293 89827117
Cholestasis 48.82 10.98 159 793878 36140 89798270
Blepharospasm 48.74 10.98 719 793318 54726 89779684
Product prescribing error 48.68 10.98 121 793916 30024 89804386
Proctalgia 48.53 10.98 7 794030 8191 89826219
Glomerular filtration rate decreased 48.49 10.98 46 793991 16886 89817524
Shock 48.46 10.98 113 793924 28665 89805745
Amenorrhoea 48.37 10.98 21 794016 11701 89822709
Pre-existing disease 48.34 10.98 27 794010 175 89834235
Premature delivery 47.94 10.98 176 793861 38586 89795824
Skin ulcer 47.87 10.98 659 793378 49416 89784994
Oxygen saturation decreased 47.78 10.98 1257 792780 106226 89728184
Atelectasis 47.73 10.98 88 793949 24321 89810089
Pancreatitis 47.59 10.98 387 793650 69439 89764971
Cerebral toxoplasmosis 47.35 10.98 60 793977 1345 89833065
Hiatus hernia 47.34 10.98 94 793943 25267 89809143
Eructation 47.34 10.98 18 794019 10864 89823546
Head discomfort 47.22 10.98 44 793993 16289 89818121
Laryngeal disorder 47.00 10.98 54 793983 1089 89833321
Mean platelet volume decreased 46.90 10.98 89 793948 2861 89831549
Lupus nephritis 46.33 10.98 119 793918 4713 89829697
White blood cell count abnormal 46.29 10.98 158 793879 7346 89827064
Skin fissures 46.28 10.98 69 793968 20740 89813670
Meningoencephalitis viral 46.26 10.98 33 794004 344 89834066
Hepatic failure 46.16 10.98 185 793852 39543 89794867
Retinitis 46.13 10.98 528 793509 37930 89796480
Frequent bowel movements 45.80 10.98 301 793736 56634 89777776
Breast pain 45.71 10.98 17 794020 10401 89824009
Pulseless electrical activity 45.68 10.98 11 794026 8921 89825489
Hypovolaemia 45.67 10.98 26 794011 12405 89822005
Adverse reaction 45.64 10.98 429 793608 29283 89805127
Brain oedema 45.52 10.98 51 793986 17334 89817076
Urine output decreased 45.40 10.98 27 794010 12576 89821834
Therapy responder 45.09 10.98 31 794006 303 89834107
Sputum discoloured 44.98 10.98 68 793969 20323 89814087
Premature labour 44.97 10.98 31 794006 13345 89821065
Second primary malignancy 44.71 10.98 195 793842 10183 89824227
Physical disability 44.50 10.98 104 793933 3877 89830533
Ankle arthroplasty 44.50 10.98 85 793952 2746 89831664
Abdominal distension 44.35 10.98 841 793196 129760 89704650
Hysterectomy 44.35 10.98 23 794014 11561 89822849
Subarachnoid haemorrhage 44.23 10.98 55 793982 17849 89816561
Pain in jaw 44.23 10.98 243 793794 47742 89786668
Bone swelling 44.19 10.98 65 793972 1686 89832724
Bronchitis chronic 43.62 10.98 115 793922 4628 89829782
Spinal stenosis 43.60 10.98 53 793984 17371 89817039
Hepatic steatosis 43.59 10.98 171 793866 36774 89797636
Cholecystitis 43.52 10.98 51 793986 16989 89817421
Micturition urgency 43.46 10.98 22 794015 11211 89823199
Dermatitis bullous 43.34 10.98 18 794019 10298 89824112
Acne 43.29 10.98 118 793919 28389 89806021
Blood lactate dehydrogenase increased 43.18 10.98 381 793656 25551 89808859
Tension headache 43.11 10.98 7 794030 7502 89826908
Arrhythmia 42.61 10.98 208 793829 42124 89792286
Eyelid oedema 42.56 10.98 24 794013 11510 89822900
Status epilepticus 42.55 10.98 62 793975 18812 89815598
Angina unstable 42.52 10.98 6 794031 7137 89827273
West Nile viral infection 42.31 10.98 36 794001 495 89833915
Therapeutic product effect incomplete 42.24 10.98 2091 791946 191805 89642605
Metastases to lymph nodes 42.16 10.98 25 794012 11664 89822746
Anal incontinence 42.08 10.98 48 793989 16182 89818228
Ejection fraction decreased 41.91 10.98 106 793931 26147 89808263
Carpal tunnel syndrome 41.88 10.98 92 793945 23836 89810574
Infusion site reaction 41.73 10.98 298 793739 18741 89815669
Infusion site erythema 41.72 10.98 35 794002 13635 89820775
Photosensitivity reaction 41.63 10.98 57 793980 17750 89816660
Muscle twitching 41.58 10.98 94 793943 24108 89810302
Groin pain 41.47 10.98 28 794009 12185 89822225
Breast cancer 41.36 10.98 288 793749 53473 89780937
Low density lipoprotein increased 41.26 10.98 10 794027 8075 89826335
Renal injury 41.25 10.98 19 794018 10224 89824186
Rib fracture 41.22 10.98 108 793929 26327 89808083
Road traffic accident 41.22 10.98 1235 792802 106391 89728019
Hypercapnia 41.20 10.98 5 794032 6672 89827738
Renal tubular necrosis 41.15 10.98 40 793997 14515 89819895
Blood albumin decreased 41.11 10.98 52 793985 16751 89817659
Injection site irritation 41.10 10.98 3 794034 6012 89828398
Thinking abnormal 41.05 10.98 26 794011 11706 89822704
Productive cough 41.03 10.98 454 793583 76609 89757801
Central nervous system lupus 40.94 10.98 55 793982 1308 89833102
Organising pneumonia 40.91 10.98 153 793884 7444 89826966
Weight increased 40.90 10.98 4221 789816 413706 89420704
Blood lactic acid increased 40.80 10.98 13 794024 8765 89825645
Expired product administered 40.77 10.98 6 794031 6916 89827494
Mental impairment 40.64 10.98 52 793985 16668 89817742
Device failure 40.57 10.98 6 794031 6891 89827519
Staphylococcal infection 40.54 10.98 253 793784 48186 89786224
Overweight 40.44 10.98 3 794034 5931 89828479
Hypotonia 40.43 10.98 25 794012 11401 89823009
Emotional disorder 40.37 10.98 43 793994 14954 89819456
Pruritus 40.36 10.98 4141 789896 537384 89297026
Premature baby 40.22 10.98 101 793936 24976 89809434
Blood pressure inadequately controlled 40.08 10.98 4 794033 6220 89828190
Lymphoedema 39.82 10.98 37 794000 13716 89820694
Mixed liver injury 39.75 10.98 9 794028 7614 89826796
Skin lesion 39.72 10.98 180 793857 37185 89797225
Bradykinesia 39.71 10.98 6 794031 6782 89827628
Pulmonary toxicity 39.69 10.98 203 793834 11328 89823082
Bradyphrenia 39.67 10.98 9 794028 7603 89826807
Respiratory acidosis 39.60 10.98 11 794026 8108 89826302
Respiratory failure 39.46 10.98 765 793272 117653 89716757
Arteriosclerosis 39.45 10.98 23 794014 10830 89823580
Tumour marker increased 39.39 10.98 3 794034 5804 89828606
Atypical femur fracture 39.16 10.98 5 794032 6416 89827994
Abnormal faeces 38.88 10.98 6 794031 6676 89827734
Hypophosphataemia 38.43 10.98 44 793993 14810 89819600
Scoliosis 38.30 10.98 15 794022 8892 89825518
Potentiating drug interaction 38.19 10.98 3 794034 5659 89828751
Iron deficiency anaemia 38.19 10.98 95 793942 23567 89810843
Oliguria 37.93 10.98 23 794014 10601 89823809
Spinal operation 37.93 10.98 21 794016 10175 89824235
Incontinence 37.89 10.98 37 794000 13398 89821012
Bundle branch block left 37.87 10.98 11 794026 7874 89826536
Abnormal loss of weight 37.77 10.98 7 794030 6816 89827594
Choking 37.73 10.98 30 794007 12003 89822407
Parosmia 37.56 10.98 8 794029 7061 89827349
Cerebral infarction 37.53 10.98 114 793923 26482 89807928
Anticipatory anxiety 37.41 10.98 50 793987 1183 89833227
Nodule 37.41 10.98 378 793659 26308 89808102
Exercise tolerance decreased 37.27 10.98 10 794027 7541 89826869
Episcleritis 37.26 10.98 49 793988 1141 89833269
Breast cancer stage I 37.01 10.98 19 794018 9605 89824805
Monocyte count increased 36.98 10.98 168 793869 8929 89825481
Arteriosclerosis coronary artery 36.87 10.98 19 794018 9584 89824826
Upper-airway cough syndrome 36.86 10.98 47 793990 15088 89819322
Drug level below therapeutic 36.76 10.98 4 794033 5810 89828600
Intervertebral disc protrusion 36.66 10.98 119 793918 27077 89807333
Systemic lupus erythematosus rash 36.66 10.98 71 793966 2318 89832092
Campylobacter infection 36.55 10.98 49 793988 1163 89833247
Hepatic encephalopathy 36.50 10.98 40 793997 13732 89820678
Supraventricular tachycardia 36.50 10.98 54 793983 16282 89818128
Dermatitis acneiform 36.31 10.98 6 794031 6348 89828062
Carotid artery occlusion 36.21 10.98 6 794031 6336 89828074
B-cell aplasia 36.15 10.98 25 794012 247 89834163
Euphoric mood 36.11 10.98 3 794034 5406 89829004
Respiratory distress 36.02 10.98 197 793840 38749 89795661
Infusion site swelling 35.77 10.98 30 794007 11690 89822720
Muscle tightness 35.66 10.98 39 793998 13400 89821010
Respiratory syncytial virus infection 35.62 10.98 24 794013 10456 89823954
Steroid diabetes 35.55 10.98 72 793965 2430 89831980
Hypernatraemia 35.41 10.98 19 794018 9368 89825042
Psychomotor hyperactivity 35.32 10.98 36 794001 12777 89821633
Heparin-induced thrombocytopenia 35.32 10.98 3 794034 5309 89829101
Flank pain 35.24 10.98 72 793965 19150 89815260
Cardiac murmur 35.21 10.98 66 793971 18128 89816282
Mesenteritis 35.01 10.98 27 794010 320 89834090
Abdominal tenderness 34.98 10.98 19 794018 9305 89825105
Ligament sprain 34.87 10.98 46 793991 14553 89819857
Bladder disorder 34.86 10.98 26 794011 10746 89823664
Device use error 34.82 10.98 10 794027 7211 89827199
Hepatitis B core antibody positive 34.73 10.98 27 794010 324 89834086
Ovarian hyperstimulation syndrome 34.71 10.98 5 794032 5857 89828553
Heart rate decreased 34.59 10.98 660 793377 52845 89781565
Gastrosplenic fistula 34.56 10.98 16 794021 65 89834345
Wrong product administered 34.49 10.98 12 794025 7653 89826757
Malnutrition 34.46 10.98 69 793968 18489 89815921
Forced expiratory volume decreased 34.29 10.98 5 794032 5803 89828607
Diabetes mellitus inadequate control 34.24 10.98 70 793967 18614 89815796
Ischaemic stroke 34.23 10.98 91 793946 22075 89812335
Neurologic neglect syndrome 34.20 10.98 161 793876 8686 89825724
Impaired driving ability 34.18 10.98 3 794034 5170 89829240
Pulse absent 33.98 10.98 6 794031 6049 89828361
Large intestine polyp 33.96 10.98 20 794017 9366 89825044
Glomerulonephritis 33.82 10.98 70 793967 2400 89832010
Injection site discolouration 33.52 10.98 20 794017 9300 89825110
Mood swings 33.50 10.98 83 793954 20619 89813791
Arterial occlusive disease 33.46 10.98 205 793832 12241 89822169
Bronchopulmonary aspergillosis 33.38 10.98 192 793845 11206 89823204
Maternal exposure during breast feeding 33.13 10.98 7 794030 6213 89828197
Anaphylactic reaction 32.89 10.98 1002 793035 86522 89747888
Hypercalcaemia 32.88 10.98 451 793586 33789 89800621
Musculoskeletal disorder 32.78 10.98 313 793724 21456 89812954
Foot fracture 32.77 10.98 121 793916 26485 89807925
Pneumocystis jirovecii infection 32.77 10.98 60 793977 1876 89832534
Device adhesion issue 32.76 10.98 9 794028 6682 89827728
Carotid artery thrombosis 32.66 10.98 162 793875 8930 89825480
Myelosuppression 32.60 10.98 655 793382 52936 89781474
Posterior reversible encephalopathy syndrome 32.56 10.98 319 793718 22020 89812390
Movement disorder 32.55 10.98 137 793900 28882 89805528
Conjunctivitis 32.54 10.98 122 793915 26584 89807826
Myocardial ischaemia 32.51 10.98 44 793993 13770 89820640
Hyperreflexia 32.51 10.98 9 794028 6648 89827762
Blood pressure abnormal 32.39 10.98 78 793959 19567 89814843
Respiratory tract infection 32.34 10.98 711 793326 58367 89776043
Activated partial thromboplastin time prolonged 32.32 10.98 14 794023 7811 89826599
Oropharyngeal pain 32.31 10.98 765 793272 114422 89719988
Fistula 32.17 10.98 35 794002 12054 89822356
Gastrointestinal motility disorder 32.15 10.98 7 794030 6084 89828326
Atrial septal defect 32.05 10.98 16 794021 8218 89826192
Sudden death 32.00 10.98 29 794008 10880 89823530
Restless legs syndrome 31.93 10.98 96 793941 22374 89812036
Application site erythema 31.89 10.98 4 794033 5204 89829206
Essential hypertension 31.86 10.98 8 794029 6307 89828103
Arthrodesis 31.85 10.98 77 793960 2935 89831475
Faeces soft 31.73 10.98 13 794024 7498 89826912
Stupor 31.72 10.98 5 794032 5477 89828933
Pharyngitis streptococcal 31.63 10.98 39 793998 12703 89821707
Toxic skin eruption 31.62 10.98 56 793981 15718 89818692
Paranoia 31.52 10.98 40 793997 12868 89821542
Mean cell volume decreased 31.50 10.98 99 793938 4407 89830003
Immunodeficiency common variable 31.48 10.98 28 794009 410 89834000
Maternal drugs affecting foetus 31.47 10.98 4 794033 5151 89829259
Gangrene 31.47 10.98 207 793830 12669 89821741
Scar 31.45 10.98 54 793983 15341 89819069
Apnoea 31.41 10.98 22 794015 9392 89825018
Post-acute COVID-19 syndrome 31.34 10.98 46 793991 1191 89833219
Systemic candida 31.10 10.98 105 793932 4854 89829556
Hereditary angioedema 31.10 10.98 22 794015 9343 89825067
Musculoskeletal discomfort 31.05 10.98 88 793949 20903 89813507
Limb injury 31.03 10.98 156 793881 31352 89803058
Liver function test abnormal 31.01 10.98 290 793747 50555 89783855
Extrasystoles 30.90 10.98 6 794031 5651 89828759
Fine motor skill dysfunction 30.75 10.98 111 793926 5308 89829102
Eye discharge 30.73 10.98 17 794020 8241 89826169
Renal vein thrombosis 30.66 10.98 32 794005 577 89833833
ADAMTS13 activity decreased 30.63 10.98 20 794017 178 89834232
Epstein-Barr virus infection reactivation 30.62 10.98 53 793984 1584 89832826
Affective disorder 30.55 10.98 15 794022 7778 89826632
Herpes zoster 30.52 10.98 1064 792973 93580 89740830
Alanine aminotransferase increased 30.46 10.98 796 793241 117542 89716868
Skin laceration 30.40 10.98 121 793916 25914 89808496
Acquired haemophilia 30.39 10.98 42 793995 1027 89833383
Ventricular extrasystoles 30.39 10.98 43 793994 13207 89821203
Anosmia 30.32 10.98 25 794012 9823 89824587
Oral candidiasis 30.29 10.98 184 793853 35271 89799139
Amylase increased 30.26 10.98 12 794025 7060 89827350
Ataxia 30.25 10.98 71 793966 17971 89816439
Influenza 30.23 10.98 959 793078 138305 89696105
Peptic ulcer haemorrhage 30.23 10.98 43 793994 1081 89833329
Aspartate aminotransferase increased 30.17 10.98 679 793358 102258 89732152
Colitis ulcerative 30.15 10.98 360 793677 59906 89774504
Pain in extremity 30.11 10.98 3471 790566 447058 89387352
Follicular lymphoma 30.07 10.98 26 794011 366 89834044
Hypoxic-ischaemic encephalopathy 30.06 10.98 3 794034 4665 89829745
Product dispensing error 30.01 10.98 38 793999 12235 89822175
Bradypnoea 29.98 10.98 3 794034 4655 89829755
Ovarian cyst 29.97 10.98 67 793970 17251 89817159
Perineal rash 29.82 10.98 15 794022 76 89834334
Pneumonitis 29.55 10.98 246 793791 43924 89790486
Brain natriuretic peptide increased 29.55 10.98 8 794029 5997 89828413
Haemorrhagic stroke 29.53 10.98 10 794027 6486 89827924
Blood pressure diastolic increased 29.45 10.98 204 793833 12702 89821708
Aspiration 29.44 10.98 58 793979 15635 89818775
Atrial tachycardia 29.43 10.98 8 794029 5982 89828428
Oxygen consumption increased 29.42 10.98 3 794034 4586 89829824
Catheter site erythema 29.39 10.98 4 794033 4890 89829520
Feeding disorder 29.29 10.98 69 793968 17443 89816967
Increased appetite 29.21 10.98 36 794001 11729 89822681
Hepatic necrosis 29.11 10.98 10 794027 6428 89827982
Product monitoring error 29.06 10.98 3 794034 4541 89829869
Gastrointestinal sounds abnormal 29.05 10.98 3 794034 4540 89829870
Pemphigoid 28.94 10.98 22 794015 9004 89825406
Vitreous floaters 28.89 10.98 15 794022 7534 89826876
Leukoerythroblastosis 28.85 10.98 23 794014 287 89834123
Personality change 28.84 10.98 14 794023 7307 89827103
Cardiovascular disorder 28.80 10.98 46 793991 13446 89820964
Pelvic fracture 28.76 10.98 56 793981 15163 89819247
Exostosis 28.62 10.98 638 793399 52496 89781914
B-cell lymphoma refractory 28.46 10.98 14 794023 67 89834343
Partial seizures 28.42 10.98 14 794023 7246 89827164
Ketoacidosis 28.40 10.98 7 794030 5588 89828822
Frustration tolerance decreased 28.32 10.98 17 794020 7879 89826531
Blood chloride decreased 28.25 10.98 10 794027 6309 89828101
Body height decreased 28.18 10.98 38 793999 11911 89822499
Photopsia 28.14 10.98 5 794032 5019 89829391
Peripheral coldness 28.14 10.98 49 793988 13843 89820567
Gingival swelling 28.06 10.98 5 794032 5008 89829402
Cytomegalovirus colitis 28.04 10.98 79 793958 3307 89831103
Metabolic encephalopathy 28.02 10.98 12 794025 6740 89827670
Faecaloma 27.98 10.98 30 794007 10401 89824009
Mucous stools 27.94 10.98 6 794031 5265 89829145
Secretion discharge 27.92 10.98 61 793976 15835 89818575
Abortion induced 27.84 10.98 38 793999 11850 89822560
Erythema multiforme 27.83 10.98 40 793997 12206 89822204
Non-cardiac chest pain 27.80 10.98 12 794025 6709 89827701
Infection reactivation 27.77 10.98 56 793981 1884 89832526
Galactorrhoea 27.63 10.98 4 794033 4668 89829742
Injection site haematoma 27.63 10.98 13 794024 6909 89827501
Skin plaque 27.53 10.98 28 794009 9947 89824463
Muscle disorder 27.53 10.98 7 794030 5472 89828938
Malignant transformation 27.43 10.98 30 794007 572 89833838
Pancreatic carcinoma 27.39 10.98 20 794017 8357 89826053
Behaviour disorder 27.34 10.98 4 794033 4631 89829779
Spinal pain 27.28 10.98 61 793976 15706 89818704
Ankle operation 27.27 10.98 48 793989 1454 89832956
B-lymphocyte abnormalities 27.22 10.98 21 794016 249 89834161
Hyperprolactinaemia 27.18 10.98 7 794030 5426 89828984
Diarrhoea haemorrhagic 27.14 10.98 32 794005 10631 89823779
Cholecystectomy 27.11 10.98 38 793999 11717 89822693
Glycosylated haemoglobin increased 27.10 10.98 60 793977 15502 89818908
Hypertonia 27.06 10.98 6 794031 5149 89829261
Infusion site haemorrhage 27.02 10.98 7 794030 5404 89829006
Lumbosacral plexopathy 26.89 10.98 15 794022 97 89834313
Toxic encephalopathy 26.88 10.98 22 794015 8677 89825733
Mean cell haemoglobin decreased 26.86 10.98 110 793927 5585 89828825
Bunion operation 26.76 10.98 45 793992 1313 89833097
Viral infection 26.65 10.98 233 793804 41181 89793229
Blood creatine increased 26.43 10.98 14 794023 6953 89827457
Paronychia 26.33 10.98 19 794018 7987 89826423
Post procedural haemorrhage 26.27 10.98 23 794014 8775 89825635
Neuromyelitis optica spectrum disorder 26.26 10.98 47 793990 1443 89832967
Knee operation 26.22 10.98 14 794023 6922 89827488
Tachypnoea 26.19 10.98 97 793940 21212 89813198
Uterine leiomyoma 26.19 10.98 34 794003 10830 89823580
Soft tissue disorder 26.17 10.98 90 793947 4200 89830210
Feeling drunk 26.08 10.98 5 794032 4753 89829657
Blood thyroid stimulating hormone increased 26.07 10.98 25 794012 9130 89825280
Photophobia 26.02 10.98 97 793940 21172 89813238
Psychiatric symptom 25.99 10.98 15 794022 7103 89827307
Small for dates baby 25.93 10.98 6 794031 5001 89829409
Clonus 25.88 10.98 9 794028 5741 89828669
Osteonecrosis 25.80 10.98 130 793907 26111 89808299
Ammonia increased 25.77 10.98 6 794031 4980 89829430
Hyperlactacidaemia 25.76 10.98 3 794034 4133 89830277
Lung neoplasm malignant 25.76 10.98 117 793920 24156 89810254
Renal transplant failure 25.70 10.98 40 793997 1092 89833318
Neuralgia 25.61 10.98 166 793871 31334 89803076
Nephrogenic systemic fibrosis 25.54 10.98 3 794034 4105 89830305
Neck pain 25.43 10.98 1232 792805 112731 89721679
Adjustment disorder 25.41 10.98 158 793879 9484 89824926
Tenderness 25.35 10.98 135 793902 26733 89807677
Enteritis 25.19 10.98 32 794005 10289 89824121
Rales 25.19 10.98 64 793973 15763 89818647
Blood iron abnormal 25.11 10.98 85 793952 3935 89830475
Gastrointestinal pain 25.08 10.98 37 794000 11169 89823241
Renal cyst 25.04 10.98 47 793990 12903 89821507
Cystitis haemorrhagic 24.84 10.98 105 793932 5408 89829002
Tooth extraction 24.81 10.98 39 793998 11474 89822936
Marginal zone lymphoma recurrent 24.66 10.98 9 794028 16 89834394
Haemarthrosis 24.62 10.98 3 794034 3991 89830419
Drug level above therapeutic 24.62 10.98 10 794027 5799 89828611
Multiple sclerosis 24.57 10.98 143 793894 27697 89806713
Blood magnesium decreased 24.56 10.98 64 793973 15629 89818781
Abscess 24.55 10.98 84 793953 18807 89815603
Chronic lymphocytic leukaemia transformation 24.46 10.98 12 794025 57 89834353
Vascular device infection 24.35 10.98 42 793995 11910 89822500
Internal haemorrhage 24.34 10.98 12 794025 6208 89828202
Hypertriglyceridaemia 24.32 10.98 20 794017 7869 89826541
Blood immunoglobulin A decreased 24.32 10.98 50 793987 1706 89832704
Dyspnoea at rest 24.31 10.98 6 794031 4785 89829625
Spinal osteoarthritis 24.30 10.98 86 793951 19062 89815348
Chest pain 24.22 10.98 2441 791596 317204 89517206
Haematuria 24.09 10.98 193 793844 34744 89799666
Rash pustular 24.08 10.98 21 794016 8028 89826382
Stillbirth 24.04 10.98 18 794019 7425 89826985
Obstruction 24.04 10.98 3 794034 3918 89830492
Unintentional medical device removal 24.03 10.98 16 794021 7014 89827396
Drug eruption 24.01 10.98 440 793597 34967 89799443
Injection site discomfort 23.95 10.98 11 794026 5929 89828481
Breast cancer stage II 23.93 10.98 439 793598 34895 89799515
Peptic ulcer 23.91 10.98 9 794028 5466 89828944
Tongue pruritus 23.82 10.98 32 794005 761 89833649
Rhinorrhoea 23.81 10.98 590 793447 87726 89746684
Bundle branch block right 23.75 10.98 9 794028 5444 89828966
BK virus infection 23.73 10.98 90 793947 4408 89830002
Petit mal epilepsy 23.66 10.98 7 794030 4951 89829459
Nervous system disorder 23.57 10.98 103 793934 21490 89812920
Respiration abnormal 23.56 10.98 21 794016 7942 89826468
Febrile bone marrow aplasia 23.46 10.98 156 793881 9582 89824828
Clostridium test positive 23.38 10.98 9 794028 5392 89829018
Diastolic dysfunction 23.35 10.98 18 794019 7315 89827095
Oesophageal pain 23.14 10.98 5 794032 4369 89830041
Increased tendency to bruise 23.13 10.98 43 793994 11847 89822563
Drug dependence 23.11 10.98 156 793881 29171 89805239
Subcutaneous drug absorption impaired 23.07 10.98 200 793837 13345 89821065
Porphyria acute 23.02 10.98 250 793787 17725 89816685
Rheumatic disorder 23.02 10.98 74 793963 3334 89831076
Defaecation urgency 23.01 10.98 13 794024 6229 89828181
Paraesthesia ear 22.98 10.98 24 794013 433 89833977
Polyarthritis 22.94 10.98 254 793783 18096 89816314
Myelitis 22.92 10.98 54 793983 2024 89832386
Bacterial test positive 22.74 10.98 10 794027 5529 89828881
Screaming 22.68 10.98 3 794034 3747 89830663
Vasculitis 22.65 10.98 301 793736 22392 89812018
Gout 22.57 10.98 74 793963 16785 89817625
Insomnia 22.54 10.98 2567 791470 330907 89503503
Polyomavirus viraemia 22.52 10.98 41 793996 1276 89833134
Thyroid neoplasm 22.51 10.98 82 793955 3939 89830471
Wrist deformity 22.50 10.98 71 793966 3167 89831243
Electrocardiogram ST segment elevation 22.49 10.98 4 794033 4012 89830398
Blindness transient 22.45 10.98 6 794031 4537 89829873
Ocular discomfort 22.45 10.98 14 794023 6356 89828054
Skin abrasion 22.42 10.98 40 793997 11195 89823215
Hepatitis acute 22.42 10.98 38 793999 10849 89823561
Retching 22.39 10.98 89 793948 19070 89815340
Postoperative wound infection 22.38 10.98 53 793984 13373 89821037
Hepatic cyst 22.38 10.98 15 794022 6553 89827857
Thyroid function test abnormal 22.28 10.98 4 794033 3985 89830425
Cheilitis 22.26 10.98 8 794029 4999 89829411
Ulcer haemorrhage 22.23 10.98 339 793698 25982 89808428
Intervertebral disc disorder 22.19 10.98 10 794027 5450 89828960
Uterine haemorrhage 22.15 10.98 7 794030 4745 89829665
Meningitis herpes 22.06 10.98 19 794018 266 89834144
Polydipsia 22.05 10.98 5 794032 4226 89830184
Stress cardiomyopathy 22.04 10.98 53 793984 13302 89821108
Procedural complication 22.02 10.98 12 794025 5866 89828544
Osteopenia 22.02 10.98 115 793922 22887 89811523
Cardiac operation 21.97 10.98 4 794033 3945 89830465
Duodenal ulcer 21.90 10.98 31 794006 9521 89824889
Bronchospasm 21.87 10.98 100 793937 20609 89813801
Vitamin D decreased 21.85 10.98 45 793992 11934 89822476
Cell-mediated immune deficiency 21.84 10.98 12 794025 75 89834335
Malabsorption 21.81 10.98 9 794028 5169 89829241
Haemoglobin increased 21.81 10.98 20 794017 7461 89826949
Meningitis enteroviral 21.72 10.98 9 794028 26 89834384
Madarosis 21.71 10.98 3 794034 3626 89830784
Compression fracture 21.71 10.98 27 794010 8762 89825648
Inability to afford medication 21.66 10.98 3 794034 3619 89830791
Enterovirus infection 21.64 10.98 43 793994 1431 89832979
Acute hepatitis B 21.53 10.98 21 794016 348 89834062
Nasal dryness 21.50 10.98 11 794026 5572 89828838
Nystagmus 21.45 10.98 19 794018 7208 89827202
Rash maculo-papular 21.45 10.98 242 793795 40691 89793719
Cardiac pacemaker insertion 21.44 10.98 6 794031 4401 89830009
Device occlusion 21.41 10.98 30 794007 9252 89825158
Dysphagia 21.38 10.98 786 793251 111492 89722918
Intracranial aneurysm 21.38 10.98 6 794031 4392 89830018
Eosinophilic cystitis 21.37 10.98 11 794026 59 89834351
Neutrophilia 21.35 10.98 12 794025 5766 89828644
Intracranial pressure increased 21.33 10.98 17 794020 6794 89827616
Cyst 21.27 10.98 74 793963 16487 89817923
Paradoxical drug reaction 21.27 10.98 12 794025 5754 89828656
Renal function test abnormal 21.23 10.98 19 794018 7172 89827238
Post cholecystectomy syndrome 21.23 10.98 32 794005 849 89833561
Intestinal ischaemia 21.21 10.98 28 794009 8855 89825555
Blood thyroid stimulating hormone decreased 21.10 10.98 12 794025 5728 89828682
Emphysema 21.05 10.98 47 793990 12108 89822302
Citrobacter bacteraemia 21.00 10.98 8 794029 17 89834393
Gene mutation 20.98 10.98 53 793984 2077 89832333
Product use complaint 20.95 10.98 3 794034 3530 89830880
Anovulatory cycle 20.90 10.98 15 794022 158 89834252
Diabetic neuropathy 20.86 10.98 7 794030 4567 89829843
Atrioventricular block 20.83 10.98 28 794009 8787 89825623
Femoral neck fracture 20.81 10.98 36 794001 10197 89824213
Leukopenia 20.67 10.98 1080 792957 99630 89734780
Myasthenia gravis crisis 20.63 10.98 35 794002 1029 89833381
Vasogenic cerebral oedema 20.61 10.98 39 793998 1251 89833159
Enterococcal bacteraemia 20.54 10.98 51 793986 1977 89832433
Polycystic ovaries 20.52 10.98 12 794025 5642 89828768
Hand fracture 20.43 10.98 18 794019 6847 89827563
Hepatitis cholestatic 20.42 10.98 27 794010 8534 89825876
Catatonia 20.41 10.98 14 794023 6042 89828368
Poor quality product administered 20.37 10.98 5 794032 4003 89830407
Paraesthesia 20.31 10.98 1902 792135 248424 89585986
Blood pressure increased 20.28 10.98 1999 792038 195218 89639192
Faecal calprotectin increased 20.21 10.98 5 794032 3982 89830428
Application site pain 20.21 10.98 8 794029 4712 89829698
Laryngitis 20.14 10.98 585 793452 50168 89784242
Blepharitis 20.13 10.98 5 794032 3971 89830439
Blood immunoglobulin M increased 20.11 10.98 40 793997 1332 89833078
Bing-Neel syndrome 20.10 10.98 7 794030 10 89834400
Product distribution issue 20.09 10.98 4 794033 3701 89830709
Sacroiliitis 20.06 10.98 6 794031 4213 89830197
Serum ferritin increased 20.05 10.98 21 794016 7360 89827050
Disability 20.02 10.98 483 793554 40262 89794148
Social avoidant behaviour 20.01 10.98 3 794034 3410 89831000
Localised oedema 19.98 10.98 15 794022 6179 89828231
Atrial flutter 19.97 10.98 40 793997 10718 89823692
Cartilage atrophy 19.93 10.98 15 794022 171 89834239
Pruritus allergic 19.91 10.98 46 793991 1702 89832708
Device related infection 19.90 10.98 138 793899 25648 89808762
Jaw disorder 19.90 10.98 12 794025 5547 89828863
Therapeutic reaction time decreased 19.73 10.98 4 794033 3654 89830756
Toothache 19.71 10.98 114 793923 22116 89812294
Intestinal sepsis 19.66 10.98 19 794018 311 89834099
Menstruation irregular 19.66 10.98 25 794012 8035 89826375
Appetite disorder 19.62 10.98 31 794006 9102 89825308
Ocular lymphoma 19.61 10.98 13 794024 119 89834291
Metastases to peritoneum 19.59 10.98 6 794031 4149 89830261
Vulvovaginal candidiasis 19.56 10.98 5 794032 3895 89830515
Gallbladder disorder 19.53 10.98 98 793939 19705 89814705
Intervertebral discitis 19.52 10.98 85 793952 4435 89829975
Stenotrophomonas bacteraemia 19.52 10.98 13 794024 120 89834290
Bowel movement irregularity 19.48 10.98 17 794020 6497 89827913
Ecchymosis 19.48 10.98 50 793987 12273 89822137
Bronchial secretion retention 19.40 10.98 4 794033 3611 89830799
Pneumothorax 19.39 10.98 94 793943 19073 89815337
Granulocyte count increased 19.30 10.98 42 793995 1492 89832918
Lower gastrointestinal haemorrhage 19.28 10.98 30 794007 8862 89825548
Neoplasm progression 19.21 10.98 274 793763 44212 89790198
Glossitis 19.18 10.98 4 794033 3583 89830827
Skin hyperpigmentation 19.17 10.98 19 794018 6832 89827578
Cardiac failure acute 19.17 10.98 48 793989 11881 89822529
Autoimmune haemolytic anaemia 19.17 10.98 99 793938 5546 89828864
Dermatitis 19.15 10.98 115 793922 22105 89812305
Electrocardiogram ST segment depression 19.14 10.98 3 794034 3300 89831110
Orthopnoea 19.07 10.98 19 794018 6816 89827594
Ventricular arrhythmia 19.04 10.98 7 794030 4314 89830096
Vitamin D deficiency 19.00 10.98 84 793953 17472 89816938
Drooling 18.99 10.98 8 794029 4538 89829872
Polyuria 18.92 10.98 37 794000 10003 89824407
Scratch 18.91 10.98 36 794001 9830 89824580
Allergy to chemicals 18.90 10.98 74 793963 3680 89830730
Enterovirus myocarditis 18.88 10.98 6 794031 5 89834405
Capnocytophaga sepsis 18.88 10.98 6 794031 5 89834405
Hyperaesthesia 18.85 10.98 41 793996 10661 89823749
Visual field defect 18.79 10.98 21 794016 7145 89827265
Anal fissure 18.75 10.98 12 794025 5373 89829037
Stress fracture 18.72 10.98 29 794008 8582 89825828
Plantar fasciitis 18.71 10.98 7 794030 4267 89830143
Infusion site pruritus 18.66 10.98 19 794018 6746 89827664
Failure to thrive 18.60 10.98 28 794009 8383 89826027
Sepsis 18.58 10.98 1340 792697 178474 89655936
Hypoaesthesia 18.55 10.98 3078 790959 311132 89523278
Larynx irritation 18.43 10.98 14 794023 162 89834248
Asphyxia 18.42 10.98 21 794016 7082 89827328
Subclavian artery occlusion 18.40 10.98 8 794029 27 89834383
Shock haemorrhagic 18.36 10.98 51 793986 12194 89822216
Bone marrow failure 18.35 10.98 390 793647 31831 89802579
Gardnerella test positive 18.34 10.98 7 794030 15 89834395
Encephalitis enteroviral 18.34 10.98 11 794026 83 89834327
Atrioventricular block second degree 18.33 10.98 8 794029 4444 89829966
Vulvovaginal mycotic infection 18.26 10.98 17 794020 6297 89828113
Intermenstrual bleeding 18.26 10.98 33 794004 9190 89825220
Cervix disorder 18.24 10.98 26 794011 655 89833755
Wrist surgery 18.21 10.98 31 794006 914 89833496
Haemophilus infection 18.11 10.98 39 793998 1375 89833035
Epstein-Barr virus associated lymphoproliferative disorder 18.10 10.98 58 793979 2609 89831801
Attention deficit hyperactivity disorder 18.07 10.98 7 794030 4177 89830233
Cardiac valve disease 18.05 10.98 9 794028 4626 89829784
Blood parathyroid hormone increased 18.04 10.98 4 794033 3433 89830977
Body mass index abnormal 18.03 10.98 27 794010 712 89833698
Oral pain 18.01 10.98 191 793846 32492 89801918
Coxsackie viral infection 17.97 10.98 8 794029 29 89834381
Dysgraphia 17.95 10.98 5 794032 3678 89830732
Taste disorder 17.91 10.98 684 793353 60862 89773548
Blood glucose abnormal 17.87 10.98 35 794002 9457 89824953
Endometriosis 17.86 10.98 17 794020 6231 89828179
Hypoalbuminaemia 17.86 10.98 75 793962 15822 89818588
Adenovirus reactivation 17.84 10.98 16 794021 237 89834173
Blood phosphorus decreased 17.83 10.98 11 794026 5023 89829387
Tumour flare 17.83 10.98 24 794013 572 89833838
Cerebral atrophy 17.80 10.98 14 794023 5632 89828778
Cardiac failure chronic 17.80 10.98 14 794023 5632 89828778
CD8 lymphocytes increased 17.75 10.98 7 794030 17 89834393
Ventricular hypertrophy 17.69 10.98 4 794033 3387 89831023
Arthropod bite 17.69 10.98 31 794006 8736 89825674
Skin cancer 17.64 10.98 60 793977 13459 89820951
Skin toxicity 17.63 10.98 20 794017 6759 89827651
Anaemia macrocytic 17.62 10.98 9 794028 4563 89829847
Abdominal pain upper 17.59 10.98 2601 791436 330073 89504337
Aortic arteriosclerosis 17.56 10.98 25 794012 7659 89826751
Primary mediastinal large B-cell lymphoma recurrent 17.51 10.98 11 794026 91 89834319
Endotracheal intubation 17.49 10.98 4 794033 3360 89831050
Melanocytic naevus 17.46 10.98 12 794025 5174 89829236
Spinal compression fracture 17.43 10.98 71 793966 15107 89819303
Pre-eclampsia 17.33 10.98 45 793992 11003 89823407
Norovirus infection 17.25 10.98 45 793992 1799 89832611
Laryngeal stenosis 17.23 10.98 37 794000 1302 89833108
Natural killer-cell leukaemia 17.22 10.98 11 794026 94 89834316
International normalised ratio decreased 17.19 10.98 10 794027 4714 89829696
Wheelchair user 17.15 10.98 122 793915 7663 89826747
Blood immunoglobulin A increased 17.14 10.98 36 794001 1247 89833163
Urine odour abnormal 17.12 10.98 23 794014 7221 89827189
Anxiety disorder 17.10 10.98 11 794026 4911 89829499
Splenic marginal zone lymphoma recurrent 17.06 10.98 6 794031 9 89834401
Body temperature increased 17.05 10.98 282 793755 44428 89789982
Swollen joint count 17.01 10.98 132 793905 8521 89825889
Feeling jittery 16.97 10.98 73 793964 15298 89819112
Diverticulum intestinal 16.97 10.98 34 794003 9108 89825302
Gastroenteritis viral 16.89 10.98 177 793860 30178 89804232
Oligohydramnios 16.88 10.98 23 794014 7178 89827232
Intestinal stenosis 16.81 10.98 4 794033 3270 89831140
Blood glucose fluctuation 16.80 10.98 12 794025 5071 89829339
Dyslipidaemia 16.77 10.98 40 793997 10067 89824343
Oral infection 16.76 10.98 13 794024 5267 89829143
Blood urine present 16.76 10.98 86 793951 17192 89817218
Ankle fracture 16.73 10.98 107 793930 20263 89814147
Aortic valve incompetence 16.73 10.98 20 794017 6604 89827806
Brain neoplasm 16.72 10.98 11 794026 4853 89829557
Peripheral vascular disorder 16.69 10.98 19 794018 6412 89827998
Pharyngitis 16.67 10.98 118 793919 21829 89812581
Prescription drug used without a prescription 16.66 10.98 4 794033 3251 89831159
Libido decreased 16.63 10.98 3 794034 2979 89831431
Ocular icterus 16.63 10.98 7 794030 3973 89830437
Lip oedema 16.62 10.98 10 794027 4629 89829781
Rhonchi 16.60 10.98 3 794034 2975 89831435
Coronary artery occlusion 16.58 10.98 31 794006 8523 89825887
Splenic abscess 16.55 10.98 16 794021 262 89834148
Hair colour changes 16.55 10.98 5 794032 3489 89830921
Tongue discolouration 16.55 10.98 5 794032 3488 89830922
Erythropoiesis abnormal 16.53 10.98 17 794020 301 89834109
Thermal burn 16.47 10.98 21 794016 6741 89827669
Mycoplasma test positive 16.44 10.98 12 794025 130 89834280
Gastritis erosive 16.43 10.98 21 794016 6734 89827676
Cushingoid 16.42 10.98 151 793886 10244 89824166
Escherichia bacteraemia 16.40 10.98 96 793941 5639 89828771
Acute myeloid leukaemia 16.35 10.98 263 793774 20377 89814033
Herpes zoster infection neurological 16.32 10.98 22 794015 525 89833885
Hypovolaemic shock 16.29 10.98 23 794014 7071 89827339
Tongue disorder 16.28 10.98 156 793881 10704 89823706
Pneumonia cytomegaloviral 16.21 10.98 62 793975 3049 89831361
Duodenitis 16.21 10.98 9 794028 4354 89830056
Multiple system atrophy 16.19 10.98 14 794023 197 89834213
Soft tissue sarcoma 16.19 10.98 13 794024 164 89834246
Electrocardiogram T wave inversion 16.18 10.98 6 794031 3677 89830733
Uterine cancer 16.17 10.98 14 794023 5371 89829039
Somatic symptom disorder 16.17 10.98 5 794032 3436 89830974
Miosis 16.16 10.98 37 794000 9447 89824963
Neck deformity 16.14 10.98 49 793988 2140 89832270
Immune effector cell-associated neurotoxicity syndrome 16.14 10.98 96 793941 5672 89828738
Sluggishness 16.14 10.98 17 794020 5942 89828468
General symptom 16.10 10.98 198 793839 14470 89819940
Catheter site haemorrhage 16.07 10.98 6 794031 3662 89830748
Wound complication 16.07 10.98 11 794026 4752 89829658
Neck mass 16.01 10.98 72 793965 3810 89830600
Mucosal dryness 16 10.98 4 794033 3163 89831247
Nasal discomfort 15.97 10.98 15 794022 5533 89828877
Electroencephalogram abnormal 15.88 10.98 8 794029 4088 89830322
Congenital cytomegalovirus infection 15.85 10.98 12 794025 138 89834272
Thyroid cancer 15.84 10.98 19 794018 6265 89828145
Focal dyscognitive seizures 15.83 10.98 4 794033 3140 89831270
Muscle rupture 15.81 10.98 4 794033 3137 89831273
Snoring 15.80 10.98 13 794024 5113 89829297
Panic reaction 15.77 10.98 11 794026 4706 89829704
Neutropenic infection 15.77 10.98 43 793994 1766 89832644
Geotrichum infection 15.74 10.98 23 794014 593 89833817
Scab 15.71 10.98 39 793998 9682 89824728
Lacunar infarction 15.70 10.98 5 794032 3372 89831038
Cranial nerve palsies multiple 15.69 10.98 10 794027 85 89834325
Large intestine perforation 15.67 10.98 39 793998 9673 89824737
Hypoventilation 15.63 10.98 14 794023 5282 89829128
Autoimmune hepatitis 15.60 10.98 43 793994 10308 89824102
Coronary arterial stent insertion 15.54 10.98 3 794034 2837 89831573
Macrocytosis 15.52 10.98 3 794034 2835 89831575
Oxygen therapy 15.51 10.98 4 794033 3098 89831312
Contusion 15.51 10.98 2467 791570 248749 89585661
Catheter site infection 15.46 10.98 16 794021 5638 89828772
Upper limb fracture 15.44 10.98 118 793919 21460 89812950
Platelet count abnormal 15.40 10.98 77 793960 4258 89830152
Vasoplegia syndrome 15.34 10.98 3 794034 2811 89831599
Haematocrit increased 15.34 10.98 4 794033 3074 89831336
Cardiac tamponade 15.33 10.98 16 794021 5616 89828794
Abdominal adhesions 15.27 10.98 6 794031 3549 89830861
Post procedural infection 15.25 10.98 48 793989 11026 89823384
Clear cell renal cell carcinoma 15.24 10.98 39 793998 1541 89832869
Stent placement 15.14 10.98 9 794028 4194 89830216
Craniocerebral injury 15.12 10.98 5 794032 3293 89831117
Dyspareunia 15.12 10.98 3 794034 2783 89831627
Metastatic neoplasm 15.10 10.98 12 794025 4803 89829607
Aspartate aminotransferase 15.10 10.98 25 794012 720 89833690
Serum sickness-like reaction 15.09 10.98 22 794015 566 89833844
Urine abnormality 15.03 10.98 28 794009 7709 89826701
Eosinophilic pneumonia 15.02 10.98 3 794034 2770 89831640
Gastric stenosis 14.99 10.98 9 794028 68 89834342
Germ cell cancer 14.99 10.98 9 794028 68 89834342
Anti-aquaporin-4 antibody positive 14.99 10.98 4 794033 0 89834410
Acute flaccid myelitis 14.99 10.98 4 794033 0 89834410
Eye injury 14.92 10.98 155 793882 10865 89823545
Communication disorder 14.89 10.98 5 794032 3261 89831149
Foetal growth restriction 14.87 10.98 38 793999 9342 89825068
Trigger finger 14.86 10.98 14 794023 5156 89829254
Complement factor C3 decreased 14.84 10.98 16 794021 300 89834110
Gingivitis 14.82 10.98 38 793999 9331 89825079
Interstitial lung disease 14.81 10.98 815 793222 75590 89758820
Dermatitis exfoliative 14.76 10.98 16 794021 5520 89828890
Faeces hard 14.72 10.98 5 794032 3237 89831173
Haemodynamic instability 14.71 10.98 53 793984 11686 89822724
Blood potassium abnormal 14.71 10.98 4 794033 2990 89831420
Clostridium difficile infection 14.70 10.98 226 793811 36019 89798391
Primary immunodeficiency syndrome 14.69 10.98 8 794029 49 89834361
Neurotoxicity 14.61 10.98 119 793918 21348 89813062
Selective IgG subclass deficiency 14.56 10.98 6 794031 17 89834393
Splenic marginal zone lymphoma 14.56 10.98 8 794029 50 89834360
Posture abnormal 14.55 10.98 3 794034 2708 89831702
Chronic graft versus host disease in skin 14.53 10.98 33 794004 1207 89833203
Ovarian cancer 14.51 10.98 23 794014 6744 89827666
Gastric ulcer 14.49 10.98 162 793875 27286 89807124
Lupus-like syndrome 14.48 10.98 544 793493 48302 89786108
Self-injurious ideation 14.44 10.98 5 794032 3198 89831212
Sputum increased 14.44 10.98 4 794033 2953 89831457
Campylobacter gastroenteritis 14.42 10.98 26 794011 803 89833607
Angioimmunoblastic T-cell lymphoma 14.40 10.98 14 794023 231 89834179
Drug abuser 14.39 10.98 3 794034 2687 89831723
Nail operation 14.37 10.98 43 793994 1863 89832547
Blood test abnormal 14.33 10.98 116 793921 20836 89813574
Extranodal marginal zone B-cell lymphoma (MALT type) recurrent 14.32 10.98 6 794031 18 89834392
Tongue oedema 14.28 10.98 16 794021 5438 89828972
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.24 10.98 71 793966 3922 89830488
Intestinal resection 14.21 10.98 4 794033 2923 89831487
Dysmenorrhoea 14.21 10.98 12 794025 4660 89829750
Rheumatoid factor increased 14.21 10.98 50 793987 2361 89832049
Gastrointestinal toxicity 14.20 10.98 136 793901 9331 89825079
Myeloid leukaemia 14.17 10.98 20 794017 499 89833911
Facial paralysis 14.13 10.98 79 793958 15455 89818955
Aphasia 14.13 10.98 277 793760 42535 89791875
Heart rate irregular 14.12 10.98 140 793897 24128 89810282
Cytomegalovirus chorioretinitis 14.11 10.98 50 793987 2369 89832041
Dysplasia 14.06 10.98 35 794002 1359 89833051
Aneurysm 14.00 10.98 7 794030 3593 89830817
Cardiac flutter 14.00 10.98 12 794025 4626 89829784
Purulent discharge 14.00 10.98 16 794021 5389 89829021
Infected seroma 13.98 10.98 9 794028 78 89834332
Occult blood positive 13.96 10.98 9 794028 4014 89830396
Brain death 13.95 10.98 9 794028 4012 89830398
Genitourinary tract infection 13.93 10.98 14 794023 241 89834169
Energy increased 13.91 10.98 5 794032 3125 89831285
Malaise 13.91 10.98 4762 789275 581224 89253186
Oesophageal spasm 13.90 10.98 6 794031 3355 89831055
Herpes oesophagitis 13.89 10.98 13 794024 204 89834206
Strongyloidiasis 13.88 10.98 38 793999 1564 89832846
Hypochloraemia 13.87 10.98 3 794034 2619 89831791
Ischaemic cardiomyopathy 13.80 10.98 3 794034 2610 89831800
Injection site vesicles 13.77 10.98 10 794027 4190 89830220
Formication 13.74 10.98 13 794024 4778 89829632
Leukaemic lymphoma 13.70 10.98 9 794028 81 89834329
Metabolic disorder 13.68 10.98 28 794009 7442 89826968
Anaemia of chronic disease 13.65 10.98 3 794034 2590 89831820
Bone density abnormal 13.64 10.98 72 793965 4068 89830342
Memory impairment 13.62 10.98 1516 792521 195728 89638682
Measles 13.59 10.98 17 794020 376 89834034
Seronegative arthritis 13.58 10.98 230 793807 18004 89816406
Nerve injury 13.55 10.98 153 793884 10953 89823457
Tendon pain 13.54 10.98 8 794029 3740 89830670
Oophoritis 13.53 10.98 12 794025 175 89834235
Retinal deposits 13.52 10.98 9 794028 83 89834327
Metastases to spine 13.51 10.98 8 794029 3735 89830675
Loose tooth 13.51 10.98 8 794029 3735 89830675
Refractory anaemia with an excess of blasts 13.50 10.98 18 794019 425 89833985
Intraocular pressure increased 13.49 10.98 26 794011 7067 89827343
Throat clearing 13.43 10.98 68 793969 3779 89830631
Hepatitis C RNA increased 13.43 10.98 11 794026 143 89834267
Overlap syndrome 13.42 10.98 124 793913 8424 89825986
Hepatitis 13.40 10.98 753 793284 69986 89764424
Troponin I increased 13.36 10.98 3 794034 2552 89831858
Mucocutaneous leishmaniasis 13.32 10.98 17 794020 384 89834026
Truncus arteriosus persistent 13.32 10.98 17 794020 384 89834026
Patella fracture 13.27 10.98 3 794034 2540 89831870
Plasmacytoma 13.23 10.98 4 794033 2789 89831621
Ischaemic hepatitis 13.23 10.98 4 794033 2789 89831621
Cestode infection 13.19 10.98 15 794022 299 89834111
Central venous catheterisation 13.18 10.98 4 794033 2782 89831628
Tension 13.11 10.98 8 794029 3674 89830736
Hypophysitis 13.09 10.98 3 794034 2517 89831893
Deafness congenital 13.07 10.98 10 794027 117 89834293
Abdominal rigidity 13.03 10.98 3 794034 2509 89831901
Menstrual disorder 13.03 10.98 21 794016 6117 89828293
Arteriospasm coronary 13.02 10.98 15 794022 5035 89829375
Papule 13.01 10.98 32 794005 7970 89826440
Hepatocellular injury 12.99 10.98 177 793860 28781 89805629
Cerebellar syndrome 12.98 10.98 9 794028 3863 89830547
Metastatic lymphoma 12.97 10.98 13 794024 223 89834187
Mycoplasma infection 12.95 10.98 26 794011 872 89833538
Human herpesvirus 6 infection 12.94 10.98 62 793975 3370 89831040
Central nervous system viral infection 12.89 10.98 11 794026 152 89834258
Blood chloride increased 12.86 10.98 6 794031 3204 89831206
Passenger lymphocyte syndrome 12.84 10.98 9 794028 91 89834319
Peroneal nerve palsy 12.84 10.98 19 794018 5729 89828681
Lung opacity 12.84 10.98 21 794016 6081 89828329
Intestinal haemorrhage 12.83 10.98 12 794025 4435 89829975
Distributive shock 12.81 10.98 7 794030 3417 89830993
Radius fracture 12.78 10.98 10 794027 4034 89830376
Bone lesion 12.77 10.98 23 794014 6414 89827996
Oesophageal stenosis 12.75 10.98 9 794028 3827 89830583
Exfoliative rash 12.73 10.98 6 794031 3186 89831224
Chronic lymphocytic leukaemia refractory 12.71 10.98 7 794030 44 89834366
Intraventricular haemorrhage 12.71 10.98 3 794034 2466 89831944
Blood magnesium increased 12.71 10.98 7 794030 3401 89831009
Middle ear effusion 12.70 10.98 4 794033 2717 89831693
Laryngeal pain 12.68 10.98 12 794025 4410 89830000
Wound secretion 12.67 10.98 15 794022 4975 89829435
Diffuse alveolar damage 12.67 10.98 29 794008 1066 89833344
Blood sodium increased 12.66 10.98 6 794031 3176 89831234
Poor peripheral circulation 12.66 10.98 10 794027 4015 89830395
Acanthamoeba infection 12.65 10.98 8 794029 67 89834343
Renal pain 12.64 10.98 31 794006 7728 89826682
Skin atrophy 12.62 10.98 18 794019 5511 89828899
Temporomandibular joint syndrome 12.61 10.98 10 794027 4007 89830403
Tender joint count 12.61 10.98 34 794003 1387 89833023
Mastication disorder 12.61 10.98 3 794034 2453 89831957
Urticaria 12.56 10.98 3006 791031 309728 89524682
Hepatomegaly 12.55 10.98 67 793970 13259 89821151
Pleural fibrosis 12.54 10.98 8 794029 3588 89830822
Hyperventilation 12.50 10.98 25 794012 6703 89827707
Gastric disorder 12.49 10.98 382 793655 33002 89801408
High-grade B-cell lymphoma 12.46 10.98 7 794030 46 89834364
Tooth loss 12.45 10.98 30 794007 7524 89826886
Purpura fulminans 12.45 10.98 9 794028 96 89834314
Cataract 12.44 10.98 761 793276 71331 89763079
Neck injury 12.43 10.98 3 794034 2429 89831981
Blindness 12.42 10.98 161 793876 26407 89808003
Peripheral ischaemia 12.40 10.98 19 794018 5648 89828762
CD4 lymphocytes increased 12.39 10.98 12 794025 197 89834213
Infusion site bruising 12.38 10.98 12 794025 4360 89830050
Food poisoning 12.35 10.98 16 794021 5102 89829308
Schistocytosis 12.33 10.98 7 794030 47 89834363
Gastrointestinal stoma complication 12.33 10.98 3 794034 2416 89831994
Cerebral ischaemia 12.32 10.98 28 794009 7168 89827242
Antineutrophil cytoplasmic antibody positive 12.32 10.98 23 794014 730 89833680
Neurosyphilis 12.32 10.98 6 794031 28 89834382
American trypanosomiasis 12.30 10.98 13 794024 238 89834172
Muscle haemorrhage 12.29 10.98 7 794030 3339 89831071
Fibrin D dimer increased 12.24 10.98 18 794019 5442 89828968
Retinitis viral 12.24 10.98 14 794023 281 89834129
Monoclonal gammopathy 12.22 10.98 25 794012 850 89833560
Cardiomyopathy acute 12.20 10.98 14 794023 282 89834128
Language disorder 12.20 10.98 4 794033 2648 89831762
Glucose tolerance impaired 12.16 10.98 33 794004 7952 89826458
Varicose vein 12.15 10.98 29 794008 7298 89827112
Central nervous system enteroviral infection 12.15 10.98 6 794031 29 89834381
Ganglioneuroma 12.15 10.98 10 794027 131 89834279
Choking sensation 12.14 10.98 10 794027 3932 89830478
Supraventricular extrasystoles 12.12 10.98 17 794020 5240 89829170
Polyp 12.09 10.98 31 794006 7613 89826797
Left ventricular dysfunction 12.08 10.98 77 793960 14592 89819818
Cervical spinal stenosis 12.08 10.98 4 794033 2631 89831779
Colon cancer 12.07 10.98 52 793985 10892 89823518
Hepatic cancer 12.05 10.98 15 794022 4866 89829544
Pancreatitis necrotising 12.04 10.98 3 794034 2378 89832032
Hepatitis toxic 12.04 10.98 9 794028 3716 89830694
Pathogen resistance 12.02 10.98 34 794003 8081 89826329
Skin tightness 11.93 10.98 13 794024 4475 89829935
Vaccine virus shedding 11.93 10.98 5 794032 15 89834395
Renal pseudoaneurysm 11.93 10.98 5 794032 15 89834395
Actinomycotic sepsis 11.92 10.98 13 794024 247 89834163
Right ventricular dysfunction 11.92 10.98 3 794034 2361 89832049
Gastric polyps 11.91 10.98 14 794023 4658 89829752
Decubitus ulcer 11.91 10.98 58 793979 11755 89822655
Lung diffusion test decreased 11.91 10.98 24 794013 807 89833603
Blood lactate dehydrogenase abnormal 11.90 10.98 17 794020 429 89833981
Aeromonas infection 11.89 10.98 11 794026 170 89834240
Gastric haemorrhage 11.87 10.98 28 794009 7075 89827335
Subacute sclerosing panencephalitis 11.83 10.98 6 794031 31 89834379
Seroma 11.83 10.98 6 794031 3054 89831356
Performance status decreased 11.83 10.98 12 794025 4268 89830142
Gingival pain 11.82 10.98 44 793993 9608 89824802
Coronary artery bypass 11.80 10.98 3 794034 2346 89832064
Protein total decreased 11.80 10.98 28 794009 7061 89827349
Product preparation issue 11.78 10.98 3 794034 2343 89832067
Umbilical hernia 11.76 10.98 9 794028 3671 89830739
Hair growth abnormal 11.73 10.98 9 794028 3667 89830743
T-lymphocyte count increased 11.68 10.98 13 794024 253 89834157
Gastrointestinal ulcer 11.66 10.98 5 794032 2806 89831604
Carbon dioxide decreased 11.64 10.98 5 794032 2803 89831607
Hiccups 11.60 10.98 6 794031 3020 89831390
Aphonia 11.56 10.98 62 793975 12257 89822153
Torticollis 11.52 10.98 4 794033 2554 89831856
Paraneoplastic pemphigus 11.51 10.98 9 794028 109 89834301
Urine ketone body present 11.48 10.98 4 794033 2548 89831862
Parvimonas micra infection 11.47 10.98 5 794032 17 89834393
Thyroid disorder 11.47 10.98 100 793937 17685 89816725
Rheumatoid factor 11.44 10.98 18 794019 496 89833914
Genitourinary symptom 11.44 10.98 10 794027 143 89834267
Transplant rejection 11.43 10.98 166 793871 12592 89821818
Pupillary reflex impaired 11.43 10.98 4 794033 2541 89831869
Device physical property issue 11.41 10.98 5 794032 2771 89831639
Extranodal marginal zone B-cell lymphoma (MALT type) 11.41 10.98 19 794018 550 89833860
Poikiloderma 11.39 10.98 14 794023 304 89834106
5q minus syndrome 11.38 10.98 12 794025 219 89834191
Gallbladder operation 11.38 10.98 5 794032 2766 89831644
Pleuritic pain 11.36 10.98 50 793987 10411 89823999
Lichenoid keratosis 11.35 10.98 4 794033 2530 89831880
Lymphoproliferative disorder 11.33 10.98 70 793967 4192 89830218
Septic shock 11.28 10.98 870 793167 83290 89751120
Central nervous system lesion 11.27 10.98 58 793979 11588 89822822
Left ventricular hypertrophy 11.27 10.98 23 794014 6121 89828289
Precancerous cells present 11.27 10.98 35 794002 1548 89832862
Combined immunodeficiency 11.27 10.98 10 794027 146 89834264
Splenic infection 11.26 10.98 5 794032 18 89834392
Traumatic lung injury 11.24 10.98 38 793999 1758 89832652
Encephalitis eastern equine 11.24 10.98 3 794034 0 89834410
Anti factor VIII antibody positive 11.24 10.98 3 794034 0 89834410
Autoimmune demyelinating disease 11.24 10.98 3 794034 0 89834410
Hepatic pain 11.22 10.98 9 794028 3586 89830824
Chondropathy 11.19 10.98 4 794033 2508 89831902
Lymphopenia 11.17 10.98 271 793766 22610 89811800
N-terminal prohormone brain natriuretic peptide increased 11.17 10.98 6 794031 2956 89831454
Idiopathic intracranial hypertension 11.14 10.98 9 794028 3572 89830838
Joint arthroplasty 11.13 10.98 60 793977 3417 89830993
Labelled drug-drug interaction issue 11.13 10.98 3 794034 2255 89832155
Plasma cells decreased 11.12 10.98 6 794031 36 89834374
Quadrantanopia 11.12 10.98 6 794031 36 89834374
Myopathy 11.11 10.98 71 793966 13447 89820963
Lumbar spinal stenosis 11.10 10.98 20 794017 5577 89828833
Myocarditis 11.10 10.98 73 793964 13733 89820677
Humerus fracture 11.09 10.98 46 793991 9739 89824671
Retinal haemorrhage 11.08 10.98 21 794016 5743 89828667
Retroperitoneal haematoma 11.07 10.98 8 794029 3360 89831050
Fluid retention 11.05 10.98 645 793392 87446 89746964
Functional gastrointestinal disorder 11.05 10.98 17 794020 5045 89829365
Appendicitis 11.05 10.98 49 793988 10182 89824228
Ejection fraction abnormal 11.04 10.98 4 794033 2487 89831923
Blindness unilateral 11.03 10.98 33 794004 7703 89826707
Systemic sclerosis pulmonary 10.98 10.98 6 794031 37 89834373

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 4900.46 11.81 10797 225473 627538 41757527
Disease progression 2206.84 11.81 3304 232966 140352 42244713
Febrile neutropenia 1572.90 11.81 3290 232980 182413 42202652
No adverse event 1250.22 11.81 1300 234970 37721 42347344
Progressive multifocal leukoencephalopathy 1139.30 11.81 741 235529 10795 42374270
Hypogammaglobulinaemia 1087.43 11.81 728 235542 11163 42373902
Diffuse large B-cell lymphoma recurrent 1067.83 11.81 528 235742 4358 42380707
COVID-19 983.97 11.81 2058 234212 113890 42271175
Neutropenia 962.84 11.81 2852 233418 196579 42188486
Infusion related reaction 754.86 11.81 1271 234999 59535 42325530
Drug effective for unapproved indication 739.36 11.81 460 235810 6173 42378892
Intentional product use issue 730.44 11.81 1376 234894 70457 42314608
Hepatitis B reactivation 706.72 11.81 392 235878 4186 42380879
Hepatitis B 674.65 11.81 436 235834 6275 42378790
Drug ineffective 643.25 11.81 5796 230474 624401 41760664
Drug interaction 591.47 11.81 376 235894 266623 42118442
Tumour lysis syndrome 589.99 11.81 671 235599 21560 42363505
Pneumocystis jirovecii pneumonia 575.39 11.81 704 235566 24477 42360588
Drug abuse 562.71 11.81 3 236267 104768 42280297
Lymphoma 542.78 11.81 523 235747 13798 42371267
Cytomegalovirus infection 527.05 11.81 766 235504 31540 42353525
Cytokine release syndrome 469.88 11.81 867 235403 43660 42341405
Completed suicide 459.69 11.81 17 236253 96448 42288617
COVID-19 pneumonia 456.57 11.81 581 235689 21032 42364033
Toxicity to various agents 433.32 11.81 380 235890 228756 42156309
Myelodysplastic syndrome 428.59 11.81 578 235692 22167 42362898
Drug ineffective for unapproved indication 423.42 11.81 847 235423 45316 42339749
Product dose omission issue 416.86 11.81 167 236103 154198 42230867
Cytomegalovirus infection reactivation 413.78 11.81 403 235867 10775 42374290
Myelosuppression 412.11 11.81 776 235494 39685 42345380
Overdose 403.99 11.81 53 236217 105211 42279854
Therapy partial responder 368.44 11.81 503 235767 19518 42365547
Diffuse large B-cell lymphoma refractory 364.11 11.81 191 236079 1806 42383259
Disease recurrence 354.30 11.81 610 235660 29068 42355997
Rhabdomyolysis 339.45 11.81 24 236246 77995 42307070
Product use in unapproved indication 328.01 11.81 1942 234328 182514 42202551
Fall 326.52 11.81 497 235773 234023 42151042
Chills 321.75 11.81 1199 235071 92867 42292198
Apparent death 319.78 11.81 219 236051 3489 42381576
Cytopenia 316.54 11.81 436 235834 17061 42368004
Synovitis 315.45 11.81 410 235860 15157 42369908
Agranulocytosis 314.03 11.81 589 235681 30023 42355042
Infection 307.78 11.81 1334 234936 110734 42274331
Lymphadenopathy 302.08 11.81 609 235661 32756 42352309
Somnolence 295.44 11.81 211 236059 140894 42244171
Treatment failure 287.22 11.81 881 235389 61743 42323322
Pancytopenia 284.83 11.81 1350 234920 116393 42268672
Neutrophil count decreased 275.04 11.81 875 235395 62540 42322525
Bone marrow failure 267.96 11.81 577 235693 32516 42352549
Hospitalisation 261.13 11.81 48 236222 74282 42310783
Intentional overdose 260.19 11.81 5 236265 51451 42333614
Fatigue 246.24 11.81 1414 234856 434227 41950838
Haematotoxicity 245.82 11.81 304 235966 10681 42374384
Post transplant lymphoproliferative disorder 244.82 11.81 277 235993 8843 42376222
Dizziness 244.21 11.81 648 235622 248606 42136459
B-cell lymphoma recurrent 239.80 11.81 110 236160 752 42384313
Blood pressure diastolic abnormal 236.33 11.81 226 236044 5902 42379163
Lymphopenia 227.52 11.81 420 235850 21143 42363922
Confusional state 227.50 11.81 361 235909 167236 42217829
B-lymphocyte count decreased 226.51 11.81 106 236164 763 42384302
Sepsis 226.43 11.81 1882 234388 197452 42187613
Bronchopulmonary aspergillosis 223.58 11.81 393 235877 19036 42366029
Chronic lymphocytic leukaemia recurrent 223.48 11.81 97 236173 571 42384494
Blood lactate dehydrogenase increased 217.19 11.81 460 235810 25621 42359444
Diffuse large B-cell lymphoma 213.75 11.81 263 236007 9191 42375874
Contraindicated product administered 213.09 11.81 448 235822 24824 42360241
Septic shock 209.27 11.81 1034 235236 90638 42294427
Pyrexia 207.26 11.81 3197 233073 390845 41994220
Mantle cell lymphoma recurrent 207.15 11.81 105 236165 918 42384147
Epstein-Barr virus infection 206.38 11.81 262 236008 9456 42375609
Anxiety 205.79 11.81 212 236058 118348 42266717
Vomiting 199.58 11.81 877 235393 288846 42096219
Diarrhoea 198.18 11.81 1621 234649 459228 41925837
Encephalitis cytomegalovirus 193.70 11.81 107 236163 1132 42383933
Hypoglycaemia 193.12 11.81 47 236223 59807 42325258
Blood pressure systolic abnormal 192.87 11.81 193 236077 5335 42379730
Aspergillus infection 192.23 11.81 328 235942 15509 42369556
Leukopenia 191.63 11.81 872 235398 73874 42311191
Suicide attempt 187.29 11.81 19 236251 46081 42338984
Hallucination 183.90 11.81 46 236224 57461 42327604
Suicidal ideation 180.55 11.81 26 236244 48135 42336930
Injection site pain 179.55 11.81 49 236221 57749 42327316
Electrocardiogram QT prolonged 177.16 11.81 27 236243 47918 42337147
Ill-defined disorder 175.18 11.81 320 235950 15976 42369089
Thrombocytopenia 174.81 11.81 1716 234554 188563 42196502
Muscle spasms 174.38 11.81 133 236137 85911 42299154
Intentional product misuse 173.52 11.81 63 236207 61837 42323228
Blood pressure systolic increased 173.13 11.81 439 235831 27529 42357536
BK virus infection 172.75 11.81 228 236042 8556 42376509
Vaccination failure 171.43 11.81 105 236165 1367 42383698
International normalised ratio increased 169.38 11.81 31 236239 48137 42336928
Aggression 162.88 11.81 25 236245 44138 42340927
Hyponatraemia 162.24 11.81 194 236076 101268 42283797
Humoral immune defect 161.70 11.81 65 236205 305 42384760
Decreased appetite 160.96 11.81 541 235729 192596 42192469
Stress 160.86 11.81 26 236244 44186 42340879
Second primary malignancy 160.40 11.81 230 236040 9345 42375720
Neutropenic sepsis 160.00 11.81 304 235966 15642 42369423
Constipation 158.68 11.81 422 235848 161869 42223196
Plasma cell myeloma 158.17 11.81 35 236235 47543 42337522
Drug intolerance 157.86 11.81 870 235400 79554 42305511
Serum sickness 156.34 11.81 116 236154 2109 42382956
Blood pressure fluctuation 155.89 11.81 412 235858 26496 42358569
JC virus infection 153.83 11.81 130 236140 2874 42382191
Coma 152.68 11.81 53 236217 53501 42331564
Agitation 149.81 11.81 85 236185 64229 42320836
Cytomegalovirus chorioretinitis 148.16 11.81 154 236116 4457 42380608
Depression 145.29 11.81 246 236024 111117 42273948
Therapy non-responder 144.63 11.81 633 235637 52726 42332339
Sedation 142.97 11.81 6 236264 30469 42354596
Herpes zoster 139.02 11.81 503 235767 38374 42346691
Neoplasm progression 135.69 11.81 411 235859 28589 42356476
White blood cell count decreased 134.14 11.81 1059 235211 109337 42275728
Post-acute COVID-19 syndrome 131.54 11.81 59 236211 380 42384685
Oxygen saturation decreased 131.12 11.81 706 235564 63981 42321084
Blood creatine phosphokinase increased 130.80 11.81 52 236218 48286 42336779
Seizure 129.93 11.81 298 235972 120263 42264802
Hepatitis E 129.30 11.81 120 236150 3014 42382051
Loss of consciousness 127.99 11.81 196 236074 92158 42292907
Febrile bone marrow aplasia 127.72 11.81 214 236056 9967 42375098
Throat irritation 127.68 11.81 246 236024 12790 42372275
Dry skin 127.56 11.81 54 236216 48284 42336781
Acquired gene mutation 126.13 11.81 89 236181 1491 42383574
Dehydration 124.37 11.81 388 235882 141379 42243686
Lymphoma transformation 123.73 11.81 60 236210 472 42384593
Cerebrovascular accident 121.84 11.81 220 236050 96940 42288125
Nausea 121.11 11.81 1514 234756 395285 41989780
Pneumocystis jirovecii infection 120.89 11.81 111 236159 2749 42382316
Nightmare 120.51 11.81 4 236266 25008 42360057
Joint swelling 120.44 11.81 716 235554 67306 42317759
Gait disturbance 120.14 11.81 225 236045 97775 42287290
Accidental overdose 119.55 11.81 10 236260 28320 42356745
Asthma 117.92 11.81 103 236167 62211 42322854
Bradycardia 116.94 11.81 183 236087 85301 42299764
Spinal instability 115.67 11.81 60 236210 553 42384512
Coronary artery disease 112.75 11.81 80 236190 53640 42331425
Babesiosis 112.72 11.81 44 236226 188 42384877
Sleep disorder 111.38 11.81 64 236206 48031 42337034
Mucosal inflammation 111.21 11.81 555 235715 48819 42336246
Cardio-respiratory arrest 110.86 11.81 97 236173 58539 42326526
Pneumonia cytomegaloviral 110.19 11.81 125 236145 4001 42381064
Immune effector cell-associated neurotoxicity syndrome 109.65 11.81 192 236078 9269 42375796
Diverticulitis 109.60 11.81 326 235944 22447 42362618
Pneumonia 109.39 11.81 3087 233183 419062 41966003
Wrong technique in product usage process 108.76 11.81 50 236220 42585 42342480
Abdominal distension 108.54 11.81 143 236127 71592 42313473
Immunosuppression 107.80 11.81 179 236091 8274 42376791
Insomnia 107.73 11.81 318 235952 117935 42267130
Epstein-Barr virus infection reactivation 105.33 11.81 99 236171 2528 42382537
Abdominal pain 104.59 11.81 623 235647 189848 42195217
Syncope 104.45 11.81 249 236021 99157 42285908
Memory impairment 103.82 11.81 76 236194 50146 42334919
Acute myeloid leukaemia 103.72 11.81 315 235955 21941 42363124
Medication error 103.16 11.81 28 236242 33126 42351939
Oedema peripheral 102.77 11.81 397 235873 135679 42249386
Metabolic acidosis 101.45 11.81 83 236187 51775 42333290
Dyspnoea 101.37 11.81 1786 234484 440835 41944230
Red blood cell sedimentation rate increased 100.55 11.81 190 236080 9734 42375331
Chondropathy 100.36 11.81 70 236200 1150 42383915
Myocardial infarction 100.07 11.81 352 235918 123657 42261408
Psoriasis 99.89 11.81 74 236196 48530 42336535
Dysgeusia 98.89 11.81 33 236237 34156 42350909
Drug withdrawal syndrome 98.62 11.81 5 236265 21544 42363521
C-reactive protein increased 96.92 11.81 644 235626 62916 42322149
Platelet count decreased 96.33 11.81 1183 235087 137398 42247667
Hallucination, visual 95.81 11.81 5 236265 21015 42364050
Treatment noncompliance 94.82 11.81 45 236225 37627 42347438
Incorrect dose administered 93.81 11.81 93 236177 52881 42332184
Arthropathy 93.43 11.81 368 235902 29229 42355836
Enterococcal infection 92.96 11.81 206 236064 11833 42373232
Coombs positive haemolytic anaemia 92.68 11.81 67 236203 1168 42383897
Central nervous system lymphoma 92.40 11.81 70 236200 1315 42383750
Blood immunoglobulin A decreased 92.14 11.81 54 236216 645 42384420
Dyskinesia 89.99 11.81 16 236254 25374 42359691
Bacteraemia 89.52 11.81 324 235946 24716 42360349
Adenovirus infection 89.27 11.81 146 236124 6663 42378402
Frequent bowel movements 89.12 11.81 8 236262 21399 42363666
Hyperkalaemia 88.99 11.81 196 236074 80262 42304803
Atlantoaxial instability 88.52 11.81 45 236225 396 42384669
Angioedema 88.16 11.81 64 236206 42413 42342652
Sarcoidosis 87.40 11.81 105 236165 3577 42381488
Ear pruritus 86.92 11.81 53 236217 684 42384381
Strongyloidiasis 86.67 11.81 101 236169 3330 42381735
Adverse drug reaction 86.41 11.81 50 236220 37384 42347681
Autoimmune haemolytic anaemia 86.00 11.81 130 236140 5541 42379524
Haematochezia 85.86 11.81 119 236151 58317 42326748
Cystitis haemorrhagic 85.28 11.81 149 236121 7180 42377885
Irritability 85.20 11.81 25 236245 28103 42356962
Cardiac failure congestive 84.79 11.81 221 236049 85381 42299684
Malaise 84.18 11.81 761 235509 211395 42173670
Diabetic ketoacidosis 83.99 11.81 12 236258 22355 42362710
Lymphadenitis 82.73 11.81 85 236185 2426 42382639
Follicular lymphoma 81.65 11.81 43 236227 410 42384655
Pseudomonas infection 81.48 11.81 233 236037 15690 42369375
Cystitis viral 81.15 11.81 62 236208 1180 42383885
Cardiac arrest 80.57 11.81 322 235948 108998 42276067
Disorientation 79.28 11.81 52 236218 36337 42348728
Asthenia 78.30 11.81 1091 235179 279702 42105363
Myalgia 77.98 11.81 272 235998 95808 42289257
Dry mouth 77.79 11.81 64 236206 39815 42345250
Pain in extremity 77.75 11.81 502 235768 150102 42234963
Erectile dysfunction 77.58 11.81 21 236249 24892 42360173
Chest pain 77.27 11.81 455 235815 139075 42245990
Lactic acidosis 77.26 11.81 82 236188 45179 42339886
Sleep disorder due to a general medical condition 76.95 11.81 5 236265 17448 42367617
Mineral metabolism disorder 76.90 11.81 40 236230 371 42384694
Incorrect route of product administration 76.61 11.81 20 236250 24285 42360780
Heart rate decreased 76.23 11.81 402 235868 36130 42348935
Glomerulonephritis 75.88 11.81 82 236188 2484 42382581
Herpes simplex 75.83 11.81 139 236131 6956 42378109
Posterior reversible encephalopathy syndrome 74.95 11.81 197 236073 12624 42372441
Abdominal pain upper 74.59 11.81 223 236047 82386 42302679
Dislocation of vertebra 74.25 11.81 40 236230 401 42384664
Eczema 73.86 11.81 49 236221 34037 42351028
Labelled drug-drug interaction medication error 73.31 11.81 3 236267 15579 42369486
C-reactive protein abnormal 73.24 11.81 160 236110 9101 42375964
Adenoviral hepatitis 73.20 11.81 43 236227 516 42384549
Respiratory arrest 73.01 11.81 33 236237 28391 42356674
Candida infection 72.54 11.81 274 235996 21336 42363729
Pneumonia fungal 72.32 11.81 158 236112 8988 42376077
Unevaluable event 72.02 11.81 51 236219 34237 42350828
Pulmonary thrombosis 71.53 11.81 149 236121 8199 42376866
Vision blurred 71.49 11.81 117 236153 53582 42331483
Intentional self-injury 71.28 11.81 3 236267 15199 42369866
Lymphocytosis 71.24 11.81 86 236184 2945 42382120
Interstitial lung disease 71.08 11.81 706 235564 77756 42307309
Depressed mood 70.43 11.81 21 236249 23363 42361702
Lethargy 70.38 11.81 94 236176 46796 42338269
Depressed level of consciousness 70.15 11.81 98 236172 47872 42337193
Secondary immunodeficiency 70.15 11.81 49 236221 807 42384258
Obstructive airways disorder 69.70 11.81 25 236245 24734 42360331
Unresponsive to stimuli 69.60 11.81 44 236226 31359 42353706
Arthritis bacterial 69.19 11.81 120 236150 5748 42379317
Withdrawal syndrome 69.00 11.81 3 236267 14772 42370293
Injection site swelling 68.92 11.81 7 236263 16966 42368099
Blood immunoglobulin G decreased 68.52 11.81 74 236196 2240 42382825
Acute kidney injury 68.33 11.81 1534 234736 365803 42019262
Organising pneumonia 67.56 11.81 137 236133 7395 42377670
Encephalitis enteroviral 67.33 11.81 29 236241 167 42384898
B-cell lymphoma refractory 66.66 11.81 30 236240 195 42384870
Haemolysis 66.21 11.81 157 236113 9432 42375633
Impaired quality of life 65.81 11.81 3 236267 14174 42370891
Ventricular fibrillation 65.68 11.81 43 236227 30080 42354985
Inappropriate schedule of product administration 64.79 11.81 292 235978 95610 42289455
Pneumonia adenoviral 64.36 11.81 35 236235 358 42384707
Klebsiella infection 64.09 11.81 172 236098 11160 42373905
Chronic lymphocytic leukaemia 63.92 11.81 104 236166 4725 42380340
Injury 63.74 11.81 22 236248 22294 42362771
Lymphocyte count decreased 63.60 11.81 314 235956 27495 42357570
Squamous cell carcinoma 63.56 11.81 187 236083 12795 42372270
Therapy interrupted 63.44 11.81 22 236248 22228 42362837
Ureaplasma infection 63.12 11.81 41 236229 595 42384470
Delirium 63.09 11.81 122 236148 52397 42332668
Drug dependence 62.80 11.81 42 236228 29052 42356013
JC polyomavirus test positive 62.00 11.81 49 236221 982 42384083
Miosis 61.91 11.81 3 236267 13443 42371622
Platelet count abnormal 61.62 11.81 88 236182 3561 42381504
Prostatic specific antigen increased 61.45 11.81 10 236260 16915 42368150
Acne cystic 61.43 11.81 39 236231 543 42384522
Melaena 60.92 11.81 75 236195 38671 42346394
Haematemesis 60.74 11.81 47 236223 30152 42354913
Sopor 60.61 11.81 3 236267 13199 42371866
Polyomavirus-associated nephropathy 60.01 11.81 110 236160 5505 42379560
Skin exfoliation 59.66 11.81 86 236184 41467 42343598
Hairy cell leukaemia recurrent 59.50 11.81 16 236254 10 42385055
Restlessness 59.49 11.81 45 236225 29204 42355861
Intestinal sepsis 59.25 11.81 42 236228 709 42384356
Respiratory failure 58.89 11.81 1018 235252 127114 42257951
Immunodeficiency common variable 58.82 11.81 30 236240 266 42384799
Immunoglobulins decreased 58.23 11.81 47 236223 972 42384093
Terminal state 58.20 11.81 95 236175 4328 42380737
Disturbance in attention 58.16 11.81 48 236222 29818 42355247
Rectal haemorrhage 58.06 11.81 117 236153 49489 42335576
Hypotension 58.00 11.81 1042 235228 256589 42128476
Appendicitis 57.71 11.81 21 236249 20592 42364473
Foot deformity 57.63 11.81 102 236168 4966 42380099
Cardiotoxicity 57.04 11.81 127 236143 7318 42377747
Therapy cessation 56.97 11.81 21 236249 20429 42364636
Psychotic disorder 56.81 11.81 47 236223 29161 42355904
Pharyngeal paraesthesia 56.39 11.81 44 236226 865 42384200
Knee arthroplasty 55.54 11.81 139 236131 8642 42376423
Onychoclasis 55.52 11.81 71 236199 2581 42382484
Hyperlipidaemia 55.23 11.81 25 236245 21491 42363574
Drug resistance 55.23 11.81 352 235918 33896 42351169
Orthostatic hypotension 54.89 11.81 53 236217 30517 42354548
Injection site erythema 54.17 11.81 22 236248 20173 42364892
Amnesia 53.79 11.81 47 236223 28390 42356675
Accidental exposure to product 53.44 11.81 23 236247 20370 42364695
Transient ischaemic attack 53.37 11.81 65 236205 33674 42351391
Cytomegalovirus viraemia 53.24 11.81 152 236118 10225 42374840
Microsporidia infection 53.20 11.81 47 236223 1105 42383960
Dystonia 52.65 11.81 5 236265 12785 42372280
Viral haemorrhagic cystitis 52.65 11.81 58 236212 1796 42383269
Hand deformity 52.41 11.81 83 236187 3685 42381380
Wheezing 52.29 11.81 144 236126 54637 42330428
Epstein-Barr viraemia 52.26 11.81 64 236206 2225 42382840
Abnormal behaviour 52.14 11.81 42 236228 26409 42358656
Deep vein thrombosis 52.13 11.81 654 235616 76303 42308762
Back pain 52.13 11.81 518 235752 141258 42243807
Muscle rigidity 51.59 11.81 4 236266 12055 42373010
Neoplasm recurrence 50.94 11.81 69 236201 2655 42382410
Dermatitis atopic 50.66 11.81 5 236265 12399 42372666
Staphylococcal bacteraemia 50.50 11.81 156 236114 10965 42374100
Activated partial thromboplastin time prolonged 50.29 11.81 13 236257 15890 42369175
Rebound effect 50.07 11.81 120 236150 7259 42377806
Therapeutic product effect decreased 49.94 11.81 380 235890 38770 42346295
Blood immunoglobulin M decreased 49.61 11.81 40 236230 826 42384239
Basal cell carcinoma 49.38 11.81 253 236017 22480 42362585
Emotional distress 49.30 11.81 14 236256 16079 42368986
Hyperpyrexia 49.27 11.81 78 236192 3462 42381603
Tumour flare 49.22 11.81 45 236225 1108 42383957
Cerebral haemorrhage 49.02 11.81 88 236182 38878 42346187
Temperature intolerance 48.91 11.81 92 236178 4696 42380369
Injection site bruising 48.81 11.81 4 236266 11521 42373544
Blood urea increased 47.94 11.81 67 236203 32726 42352339
Cytomegalovirus test positive 47.92 11.81 86 236184 4233 42380832
Ventricular tachycardia 47.81 11.81 58 236212 30102 42354963
Foetal exposure during pregnancy 47.71 11.81 121 236149 47190 42337875
Haemophagocytic lymphohistiocytosis 47.70 11.81 214 236056 18008 42367057
SARS-CoV-2 antibody test negative 47.67 11.81 16 236254 39 42385026
Blood pressure diastolic increased 47.66 11.81 108 236162 6297 42378768
Drug tolerance decreased 47.55 11.81 62 236208 2298 42382767
Hypoaesthesia 47.41 11.81 219 236051 71244 42313821
Joint arthroplasty 47.41 11.81 41 236229 936 42384129
Hallucination, auditory 47.29 11.81 12 236258 14852 42370213
Mental status changes 47.04 11.81 102 236168 42013 42343052
Device issue 46.83 11.81 9 236261 13500 42371565
Pseudomonal bacteraemia 46.81 11.81 62 236208 2334 42382731
Full blood count abnormal 46.79 11.81 58 236212 29818 42355247
Myoclonus 46.75 11.81 18 236252 17047 42368018
Nephropathy toxic 46.54 11.81 201 236069 16637 42368428
Dysarthria 46.49 11.81 94 236176 39713 42345352
Mantle cell lymphoma refractory 46.14 11.81 19 236251 96 42384969
Thrombotic microangiopathy 46.00 11.81 183 236087 14599 42370466
Fear 45.91 11.81 4 236266 10961 42374104
Salivary hypersecretion 45.79 11.81 4 236266 10939 42374126
Pancreatitis acute 45.73 11.81 72 236198 33492 42351573
Cytology abnormal 45.48 11.81 28 236242 368 42384697
Chronic graft versus host disease 45.29 11.81 102 236168 5923 42379142
Headache 44.58 11.81 999 235271 238370 42146695
Cerebral aspergillosis 44.37 11.81 52 236218 1725 42383340
Human herpesvirus 6 infection 44.28 11.81 62 236208 2463 42382602
Neurological decompensation 44.04 11.81 77 236193 3712 42381353
Swollen tongue 44.03 11.81 32 236238 21199 42363866
Blood cholesterol increased 43.92 11.81 50 236220 26691 42358374
Respiratory depression 43.83 11.81 25 236245 18843 42366222
Encephalitis viral 43.74 11.81 48 236222 1480 42383585
Blood glucose increased 43.65 11.81 235 236035 73464 42311601
Pneumonitis 43.57 11.81 387 235883 41331 42343734
Flatulence 43.56 11.81 45 236225 25107 42359958
Bone marrow infiltration 43.26 11.81 23 236247 224 42384841
Acute myocardial infarction 43.03 11.81 171 236099 57994 42327071
Drug use disorder 42.64 11.81 4 236266 10329 42374736
Altered state of consciousness 42.55 11.81 60 236210 29199 42355866
B-cell lymphoma 42.45 11.81 88 236182 4825 42380240
Device leakage 42.39 11.81 4 236266 10281 42374784
Cytomegalovirus enterocolitis 42.31 11.81 45 236225 1338 42383727
Chronic lymphocytic leukaemia transformation 42.30 11.81 22 236248 204 42384861
Cardiomegaly 42.23 11.81 20 236250 16746 42368319
Polyneuropathy 42.16 11.81 210 236060 18451 42366614
Skin fissures 41.99 11.81 3 236267 9673 42375392
Staphylococcal sepsis 41.91 11.81 149 236121 11265 42373800
Colitis ulcerative 41.85 11.81 50 236220 26125 42358940
Intervertebral disc space narrowing 41.84 11.81 41 236229 1104 42383961
Delusion 41.27 11.81 15 236255 14719 42370346
CD4 lymphocytes decreased 41.11 11.81 52 236218 1869 42383196
Product quality issue 41.10 11.81 24 236246 17858 42367207
Device malfunction 41.10 11.81 9 236261 12318 42372747
Osteosclerosis 40.90 11.81 46 236224 1458 42383607
Psychomotor hyperactivity 40.86 11.81 6 236264 10952 42374113
Rash 40.60 11.81 1197 235073 275757 42109308
Lip swelling 40.46 11.81 28 236242 19025 42366040
Neuroborreliosis 40.42 11.81 15 236255 54 42385011
Neck pain 40.31 11.81 65 236205 29949 42355116
Toxoplasmosis 40.08 11.81 47 236223 1560 42383505
End stage renal disease 40.04 11.81 190 236080 16368 42368697
Marginal zone lymphoma recurrent 40.00 11.81 15 236255 56 42385009
Liver function test abnormal 39.99 11.81 74 236196 32317 42352748
Tooth fracture 39.80 11.81 78 236192 4106 42380959
Atypical pneumonia 39.73 11.81 77 236193 4020 42381045
Transplant rejection 39.72 11.81 165 236105 13423 42371642
Escherichia infection 39.50 11.81 146 236124 11250 42373815
Poisoning 39.45 11.81 16 236254 14683 42370382
Blood potassium decreased 39.39 11.81 33 236237 20351 42364714
5q minus syndrome 39.37 11.81 18 236252 122 42384943
Haemoptysis 39.27 11.81 128 236142 46039 42339026
Pneumonia klebsiella 39.22 11.81 78 236192 4151 42380914
Hypothyroidism 38.99 11.81 74 236196 32010 42353055
Mucormycosis 38.97 11.81 107 236163 7036 42378029
Hypomagnesaemia 38.92 11.81 61 236209 28427 42356638
Chromaturia 38.87 11.81 20 236250 15969 42369096
Herpes simplex encephalitis 38.71 11.81 25 236245 359 42384706
Bladder transitional cell carcinoma 38.68 11.81 60 236210 2616 42382449
Dyspnoea exertional 38.66 11.81 145 236125 50003 42335062
Graft versus host disease 38.61 11.81 158 236112 12767 42372298
Chronic lymphocytic leukaemia refractory 38.51 11.81 16 236254 83 42384982
Post procedural complication 38.48 11.81 11 236259 12579 42372486
Paraesthesia 38.30 11.81 244 236026 73215 42311850
Sweat gland tumour 38.24 11.81 26 236244 409 42384656
Pancreatitis 38.18 11.81 118 236152 43150 42341915
Synovial cyst 38.08 11.81 59 236211 2570 42382495
Neoplasm 38.00 11.81 98 236172 6207 42378858
Epistaxis 37.98 11.81 216 236054 66610 42318455
Short stature 37.97 11.81 26 236244 414 42384651
Substance abuse 37.97 11.81 3 236267 8902 42376163
Splenomegaly 37.92 11.81 191 236079 16856 42368209
Osteonecrosis of jaw 37.86 11.81 30 236240 19019 42366046
Peripheral swelling 37.85 11.81 319 235951 89951 42295114
Tooth loss 37.78 11.81 76 236194 4078 42380987
Head injury 37.75 11.81 35 236235 20547 42364518
Palmar-plantar erythrodysaesthesia syndrome 37.75 11.81 35 236235 20547 42364518
Blood pressure diastolic decreased 37.72 11.81 135 236135 10240 42374825
Mantle cell lymphoma 37.63 11.81 44 236226 1456 42383609
Glomerulonephritis rapidly progressive 37.52 11.81 35 236235 885 42384180
Intestinal perforation 37.42 11.81 139 236131 10735 42374330
Neutropenic infection 37.42 11.81 49 236221 1824 42383241
Micturition urgency 37.10 11.81 10 236260 11888 42373177
Needle issue 37.04 11.81 3 236267 8724 42376341
Drug level increased 36.85 11.81 55 236215 26145 42358920
Feeling abnormal 36.80 11.81 231 236039 69555 42315510
Rheumatoid factor positive 36.76 11.81 33 236237 793 42384272
Rhinovirus infection 36.64 11.81 99 236171 6449 42378616
Urinary retention 36.64 11.81 116 236154 42098 42342967
Myasthenia gravis 36.61 11.81 22 236248 16115 42368950
Cushingoid 36.52 11.81 67 236203 3355 42381710
Hypokalaemia 36.49 11.81 240 236030 71481 42313584
Lung infiltration 36.40 11.81 164 236106 13825 42371240
Gastrointestinal haemorrhage 36.35 11.81 356 235914 97370 42287695
Pulmonary fibrosis 36.31 11.81 263 236007 26418 42358647
Hyperthyroidism 36.28 11.81 17 236253 14324 42370741
Syringe issue 36.15 11.81 3 236267 8553 42376512
Pneumonia escherichia 36.08 11.81 30 236240 648 42384417
Meningitis cryptococcal 35.95 11.81 65 236205 3218 42381847
Chronic obstructive pulmonary disease 35.87 11.81 204 236066 62910 42322155
Adverse event 35.87 11.81 47 236223 23593 42361472
Growth retardation 35.82 11.81 55 236215 2377 42382688
Skin discolouration 35.47 11.81 38 236232 20852 42364213
Product storage error 35.43 11.81 9 236261 11131 42373934
Injection site pruritus 35.42 11.81 5 236265 9400 42375665
Paraneoplastic pemphigus 35.29 11.81 14 236256 63 42385002
Hemianopia 35.23 11.81 34 236236 898 42384167
Anger 35.21 11.81 14 236256 13004 42372061
Hepatic failure 35.05 11.81 344 235926 37756 42347309
Mood swings 34.92 11.81 4 236266 8822 42376243
Blood pressure increased 34.69 11.81 774 235496 101154 42283911
Mydriasis 34.63 11.81 4 236266 8766 42376299
Polyarthritis 34.62 11.81 83 236187 5021 42380044
Discomfort 34.45 11.81 54 236216 25165 42359900
Pneumonia bacterial 34.33 11.81 175 236095 15517 42369548
Abdominal discomfort 34.29 11.81 260 236010 74995 42310070
Cardiac murmur 34.13 11.81 14 236256 12761 42372304
Erysipelas 34.04 11.81 94 236176 6202 42378863
Arteriosclerosis coronary artery 33.97 11.81 32 236238 18645 42366420
Ageusia 33.91 11.81 11 236259 11594 42373471
Product administration error 33.87 11.81 31 236239 18312 42366753
Cardiogenic shock 33.77 11.81 94 236176 35546 42349519
Iron deficiency anaemia 33.70 11.81 15 236255 13024 42372041
Tachycardia 33.62 11.81 378 235892 100709 42284356
Exposure during pregnancy 33.50 11.81 4 236266 8544 42376521
Prothrombin time prolonged 33.48 11.81 6 236264 9463 42375602
Osteoarthritis 33.46 11.81 241 236029 24164 42360901
Immune thrombocytopenia 33.42 11.81 137 236133 11079 42373986
Respiratory symptom 33.40 11.81 10 236260 11096 42373969
Adenovirus reactivation 33.28 11.81 23 236247 372 42384693
Escherichia sepsis 33.28 11.81 88 236182 5659 42379406
Gastrosplenic fistula 33.22 11.81 13 236257 56 42385009
Prescribed overdose 33.21 11.81 15 236255 12912 42372153
Graft versus host disease in gastrointestinal tract 33.15 11.81 82 236188 5061 42380004
Blood alkaline phosphatase increased 33.05 11.81 87 236183 33510 42351555
Parkinsonism 32.99 11.81 9 236261 10614 42374451
Product prescribing error 32.82 11.81 59 236211 26053 42359012
Blood immunoglobulin M increased 32.81 11.81 20 236250 258 42384807
Pneumonia streptococcal 32.66 11.81 44 236226 1684 42383381
Electrocardiogram abnormal 32.64 11.81 8 236262 10137 42374928
Enterovirus infection 32.55 11.81 38 236232 1255 42383810
Cystitis escherichia 32.46 11.81 18 236252 192 42384873
Venoocclusive liver disease 32.43 11.81 128 236142 10174 42374891
Anti-cyclic citrullinated peptide antibody positive 32.12 11.81 46 236224 1866 42383199
Troponin increased 32.01 11.81 35 236235 19027 42366038
Autoimmune lymphoproliferative syndrome 31.90 11.81 18 236252 199 42384866
Abdominal lymphadenopathy 31.86 11.81 34 236236 1015 42384050
Upper gastrointestinal haemorrhage 31.71 11.81 76 236194 30223 42354842
Scleroderma 31.69 11.81 44 236226 1734 42383331
Empyema 31.68 11.81 71 236199 4109 42380956
Parosmia 31.68 11.81 3 236267 7688 42377377
Burning sensation 31.65 11.81 42 236228 20971 42364094
Hypercholesterolaemia 31.34 11.81 16 236254 12833 42372232
Gait inability 31.09 11.81 49 236221 22784 42362281
Hospice care 30.97 11.81 5 236265 8508 42376557
Underdose 30.97 11.81 28 236242 16638 42368427
Acute graft versus host disease 30.81 11.81 108 236162 8107 42376958
Chronic allograft nephropathy 30.68 11.81 41 236229 1557 42383508
Human polyomavirus infection 30.67 11.81 37 236233 1266 42383799
Nervous system disorder 30.40 11.81 181 236089 17014 42368051
Atrial septal defect 30.32 11.81 4 236266 7915 42377150
Quadriparesis 30.28 11.81 50 236220 2300 42382765
Glycosylated haemoglobin increased 30.20 11.81 17 236253 12907 42372158
Contusion 30.07 11.81 125 236145 41860 42343205
Blood glucose decreased 30.05 11.81 21 236249 14198 42370867
Aspartate aminotransferase increased 30.00 11.81 278 235992 76885 42308180
Hip fracture 29.68 11.81 19 236251 13453 42371612
Human herpesvirus 8 infection 29.65 11.81 39 236231 1458 42383607
Central nervous system enteroviral infection 29.57 11.81 12 236258 58 42385007
Cytomegalovirus oesophagitis 29.30 11.81 25 236245 560 42384505
Eye irritation 29.28 11.81 13 236257 11305 42373760
Visual impairment 29.26 11.81 131 236139 42982 42342083
Haemorrhage 29.15 11.81 206 236064 60357 42324708
Injection site mass 29.12 11.81 6 236264 8569 42376496
Mania 29.10 11.81 11 236259 10536 42374529
Hypersomnia 29.08 11.81 23 236247 14595 42370470
Mental impairment 29.07 11.81 16 236254 12301 42372764
Bone marrow necrosis 28.89 11.81 19 236251 282 42384783
Disseminated mucormycosis 28.74 11.81 37 236233 1354 42383711
Pseudomonal sepsis 28.72 11.81 69 236201 4180 42380885
Sleep disorder due to general medical condition, insomnia type 28.68 11.81 38 236232 1431 42383634
Human rhinovirus test positive 28.66 11.81 19 236251 286 42384779
Alcohol poisoning 28.59 11.81 4 236266 7570 42377495
B-lymphocyte abnormalities 28.35 11.81 9 236261 17 42385048
Cryptococcosis 28.32 11.81 58 236212 3153 42381912
Hypocalcaemia 28.28 11.81 80 236190 30093 42354972
Drug level decreased 28.21 11.81 10 236260 9967 42375098
Swelling face 28.14 11.81 70 236200 27484 42357581
Congenital cardiovascular anomaly 28.05 11.81 16 236254 181 42384884
Febrile infection 28.00 11.81 53 236217 2718 42382347
Wrist deformity 27.89 11.81 20 236250 344 42384721
Hypopnoea 27.86 11.81 5 236265 7877 42377188
Surgery 27.79 11.81 34 236236 17582 42367483
Cerebral infarction 27.50 11.81 85 236185 31084 42353981
Speech disorder 27.45 11.81 77 236193 29044 42356021
B-cell aplasia 27.37 11.81 14 236256 125 42384940
Fluid retention 27.35 11.81 87 236183 31532 42353533
Proteus infection 27.21 11.81 36 236234 1354 42383711
Extravasation 27.04 11.81 48 236222 2342 42382723
Sexual dysfunction 26.98 11.81 3 236267 6772 42378293
Vena cava thrombosis 26.88 11.81 38 236232 1523 42383542
Muscle twitching 26.80 11.81 16 236254 11764 42373301
Adenoviral haemorrhagic cystitis 26.78 11.81 23 236247 520 42384545
Malignant syphilis 26.74 11.81 10 236260 37 42385028
Blood calcium increased 26.56 11.81 7 236263 8447 42376618
Pollakiuria 26.40 11.81 53 236217 22452 42362613
Microscopic polyangiitis 26.33 11.81 17 236253 244 42384821
Epstein-Barr virus associated lymphoma 26.29 11.81 31 236239 1035 42384030
Gastritis bacterial 26.10 11.81 19 236251 335 42384730
Aortic stenosis 26.07 11.81 8 236262 8737 42376328
Schizophrenia 25.94 11.81 13 236257 10537 42374528
Gout 25.84 11.81 75 236195 27980 42357085
Gene mutation 25.84 11.81 40 236230 1741 42383324
Small intestinal perforation 25.79 11.81 53 236217 2888 42382177
Immunodeficiency 25.77 11.81 94 236176 7196 42377869
Enterococcal bacteraemia 25.71 11.81 50 236220 2617 42382448
Metastatic lymphoma 25.64 11.81 20 236250 393 42384672
Nocardiosis 25.64 11.81 75 236195 5115 42379950
Accident 25.59 11.81 3 236267 6500 42378565
Eosinophilic granulomatosis with polyangiitis 25.57 11.81 8 236262 8630 42376435
B-lymphocyte count increased 25.57 11.81 10 236260 43 42385022
Chylothorax 25.48 11.81 32 236238 1142 42383923
Acute graft versus host disease in intestine 25.47 11.81 63 236207 3888 42381177
Granuloma skin 25.45 11.81 32 236238 1143 42383922
Intercepted product preparation error 25.45 11.81 5 236265 7384 42377681
Palpitations 25.32 11.81 171 236099 50626 42334439
Pneumonia viral 25.31 11.81 66 236204 4208 42380857
Klebsiella sepsis 25.27 11.81 50 236220 2651 42382414
Granulocyte count decreased 25.25 11.81 37 236233 1533 42383532
Cytomegalovirus colitis 25.16 11.81 63 236207 3918 42381147
Bone erosion 25.07 11.81 67 236203 4336 42380729
Psoriatic arthropathy 25.05 11.81 64 236206 24903 42360162
Diaphragm muscle weakness 25.03 11.81 14 236256 152 42384913
Road traffic accident 25.03 11.81 42 236228 19051 42366014
Parvovirus B19 infection reactivation 25.00 11.81 9 236261 29 42385036
Disseminated cytomegaloviral infection 24.97 11.81 17 236253 268 42384797
Panniculitis 24.93 11.81 44 236226 2137 42382928
Cerebral toxoplasmosis 24.86 11.81 43 236227 2055 42383010
Nervousness 24.83 11.81 23 236247 13509 42371556
Fat embolism syndrome 24.77 11.81 11 236259 69 42384996
Epididymitis 24.66 11.81 53 236217 2981 42382084
Faeces discoloured 24.63 11.81 35 236235 16979 42368086
Urinary incontinence 24.59 11.81 52 236218 21616 42363449
Gamma-glutamyltransferase increased 24.37 11.81 95 236175 32402 42352663
Thirst 24.30 11.81 10 236260 9098 42375967
Myocardial ischaemia 24.29 11.81 38 236232 17724 42367341
Antineutrophil cytoplasmic antibody increased 24.28 11.81 8 236262 18 42385047
Hyperviscosity syndrome 24.23 11.81 17 236253 282 42384783
Breath sounds abnormal 24.09 11.81 19 236251 12074 42372991
Rib fracture 24.08 11.81 34 236236 16537 42368528
Varicella 24.05 11.81 42 236228 2023 42383042
Balance disorder 23.95 11.81 160 236110 47485 42337580
Generalised tonic-clonic seizure 23.95 11.81 71 236199 26308 42358757
Skin burning sensation 23.90 11.81 6 236264 7481 42377584
Iron deficiency 23.83 11.81 16 236254 11045 42374020
Pneumonia aspiration 23.77 11.81 171 236099 49907 42335158
Mood altered 23.77 11.81 15 236255 10703 42374362
Scrotal cellulitis 23.53 11.81 11 236259 79 42384986
Multiple organ dysfunction syndrome 23.41 11.81 704 235566 96331 42288734
Sudden death 23.30 11.81 35 236235 16594 42368471
Viraemia 23.27 11.81 38 236232 1732 42383333
Pulmonary embolism 23.26 11.81 846 235424 118766 42266299
Shock 23.23 11.81 83 236187 29038 42356027
Chronic graft versus host disease in skin 23.20 11.81 36 236234 1570 42383495
Cardiomyopathy 23.13 11.81 184 236086 19026 42366039
Euphoric mood 23.01 11.81 4 236266 6449 42378616
Metastases to meninges 22.99 11.81 40 236230 1921 42383144
Catarrh 22.98 11.81 3 236267 5983 42379082
Leukoencephalopathy 22.96 11.81 70 236200 4884 42380181
Metastases to bone 22.92 11.81 29 236241 14780 42370285
Intraocular pressure increased 22.91 11.81 4 236266 6429 42378636
Myeloproliferative neoplasm 22.75 11.81 25 236245 772 42384293
Prerenal failure 22.71 11.81 45 236225 2388 42382677
Peripheral T-cell lymphoma unspecified 22.71 11.81 22 236248 584 42384481
Diabetes mellitus 22.70 11.81 218 236052 59869 42325196
Haematuria 22.57 11.81 208 236062 57591 42327474
Panic attack 22.45 11.81 17 236253 11028 42374037
Bacterial sepsis 22.42 11.81 83 236187 6399 42378666
Oral pain 22.42 11.81 22 236248 12574 42372491
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 22.41 11.81 8 236262 25 42385040
Emphysematous cholecystitis 22.32 11.81 11 236259 90 42384975
Gynaecomastia 22.31 11.81 22 236248 12545 42372520
Arteriosclerosis 22.29 11.81 41 236229 17948 42367117
Arrhythmogenic right ventricular dysplasia 22.26 11.81 9 236261 43 42385022
Cryoglobulinaemia 22.25 11.81 21 236249 539 42384526
Osteopenia 22.23 11.81 81 236189 6197 42378868
Electrocardiogram QRS complex prolonged 22.15 11.81 3 236267 5820 42379245
Device related infection 22.14 11.81 190 236080 20089 42364976
Acute hepatitis B 22.11 11.81 15 236255 235 42384830
Acute lung injury 22.10 11.81 35 236235 1554 42383511
Polyomavirus viraemia 22.10 11.81 41 236229 2071 42382994
Inappropriate antidiuretic hormone secretion 22.04 11.81 36 236234 16505 42368560
Disorder of orbit 22.01 11.81 11 236259 93 42384972
Presyncope 21.99 11.81 58 236212 22329 42362736
Disseminated blastomycosis 21.99 11.81 18 236252 380 42384685
Catatonia 21.96 11.81 4 236266 6235 42378830
Pruritus 21.94 11.81 840 235430 187931 42197134
Lymphoplasmacytoid lymphoma/immunocytoma 21.93 11.81 9 236261 45 42385020
Abdominal abscess 21.80 11.81 70 236200 5023 42380042
Rheumatoid nodule 21.73 11.81 50 236220 2945 42382120
Viral sepsis 21.72 11.81 12 236258 127 42384938
Cytomegalovirus gastritis 21.70 11.81 16 236254 288 42384777
Neuropathy peripheral 21.70 11.81 728 235542 101125 42283940
Limb deformity 21.66 11.81 21 236249 558 42384507
Lung adenocarcinoma 21.61 11.81 72 236198 5267 42379798
Mononeuropathy multiplex 21.59 11.81 20 236250 501 42384564
Hyperglycaemia 21.57 11.81 157 236113 45702 42339363
Hepatitis B surface antigen positive 21.56 11.81 12 236258 129 42384936
Hypophosphataemia 21.55 11.81 53 236217 20892 42364173
Blood potassium increased 21.44 11.81 44 236226 18492 42366573
Disability 21.39 11.81 77 236193 5856 42379209
Rheumatoid factor increased 21.38 11.81 23 236247 693 42384372
Drug level below therapeutic 21.38 11.81 5 236265 6540 42378525
Escherichia bacteraemia 21.34 11.81 70 236200 5079 42379986
Blood stem cell transplant failure 21.25 11.81 19 236251 454 42384611
Oedema 21.24 11.81 185 236085 51816 42333249
Nasal cavity cancer 21.22 11.81 14 236256 209 42384856
Pulmonary congestion 21.18 11.81 34 236236 15696 42369369
Blood sodium decreased 21.11 11.81 43 236227 18119 42366946
Pulmonary oedema 21.11 11.81 191 236079 53081 42331984
Haemoglobin abnormal 21.04 11.81 68 236202 4896 42380169
Blood albumin decreased 21.02 11.81 33 236237 15369 42369696
Coronary artery occlusion 21.01 11.81 18 236252 10979 42374086
Product dose omission in error 20.99 11.81 10 236260 8344 42376721
Systemic mycosis 20.91 11.81 43 236227 2344 42382721
Campylobacter infection 20.84 11.81 32 236238 1383 42383682
Acute graft versus host disease in skin 20.81 11.81 89 236181 7335 42377730
Intentional dose omission 20.74 11.81 12 236258 8974 42376091
Joint ankylosis 20.70 11.81 35 236235 1642 42383423
Crying 20.65 11.81 5 236265 6389 42378676
Pneumonia respiratory syncytial viral 20.52 11.81 32 236238 1402 42383663
Eructation 20.46 11.81 3 236267 5483 42379582
Drug level above therapeutic 20.33 11.81 4 236266 5902 42379163
Primary amyloidosis 20.23 11.81 14 236256 227 42384838
Fluoride increased 20.19 11.81 9 236261 57 42385008
Blood creatinine increased 20.17 11.81 460 235810 109543 42275522
T-lymphocyte count decreased 20.15 11.81 15 236255 274 42384791
Fungal infection 20.10 11.81 182 236088 19540 42365525
Graft versus host disease in skin 19.96 11.81 69 236201 5143 42379922
Haemorrhagic stroke 19.96 11.81 8 236262 7394 42377671
Reactive gastropathy 19.92 11.81 20 236250 555 42384510
Device occlusion 19.91 11.81 11 236259 8439 42376626
Bone marrow reticulin fibrosis 19.87 11.81 12 236258 152 42384913
Neuritis 19.83 11.81 5 236265 6215 42378850
Acute myelomonocytic leukaemia 19.82 11.81 13 236257 192 42384873
Myelitis 19.81 11.81 27 236243 1045 42384020
Meningitis meningococcal 19.77 11.81 10 236260 87 42384978
Chronic kidney disease 19.77 11.81 167 236103 47074 42337991
Heparin-induced thrombocytopenia 19.73 11.81 6 236264 6591 42378474
Pneumonia pseudomonal 19.69 11.81 66 236204 4843 42380222
Periostitis 19.66 11.81 16 236254 335 42384730
Refractory anaemia with an excess of blasts 19.62 11.81 16 236254 336 42384729
Tremor 19.61 11.81 399 235871 96530 42288535
Toxic epidermal necrolysis 19.55 11.81 79 236191 26671 42358394
Hypophagia 19.46 11.81 80 236190 26876 42358189
Traumatic lung injury 19.44 11.81 30 236240 1302 42383763
Adenocarcinoma gastric 19.40 11.81 31 236239 1387 42383678
Urethroscopy 19.38 11.81 6 236264 10 42385055
Forced expiratory volume decreased 19.37 11.81 9 236261 7621 42377444
Renal transplant failure 19.36 11.81 32 236238 1473 42383592
Pulmonary sarcoidosis 19.29 11.81 23 236247 777 42384288
Polymyositis 19.28 11.81 35 236235 1738 42383327
Gastrointestinal toxicity 19.18 11.81 57 236213 3922 42381143
Ureteric compression 19.18 11.81 15 236255 296 42384769
Haemolytic anaemia 19.15 11.81 124 236146 12003 42373062
Abscess 19.13 11.81 140 236130 14108 42370957
Neuroendocrine carcinoma of the skin 19.06 11.81 25 236245 932 42384133
Retroperitoneal lymphadenopathy 19.05 11.81 26 236244 1008 42384057
Mental disorder 19.04 11.81 45 236225 17984 42367081
Increased appetite 19.03 11.81 13 236257 8893 42376172
Acquired C1 inhibitor deficiency 19.02 11.81 6 236264 11 42385054
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.01 11.81 32 236238 1496 42383569
Vertigo 18.98 11.81 112 236158 34235 42350830
Cholelithiasis 18.98 11.81 66 236204 23280 42361785
Device related thrombosis 18.96 11.81 31 236239 1414 42383651
Mass 18.80 11.81 97 236173 8642 42376423
Metastases to bone marrow 18.76 11.81 19 236251 533 42384532
Epstein-Barr virus test positive 18.74 11.81 21 236249 663 42384402
Noninfectious myelitis 18.68 11.81 6 236264 12 42385053
Larynx irritation 18.67 11.81 5 236265 3 42385062
Opportunistic infection 18.67 11.81 37 236233 1964 42383101
Medical device implantation 18.63 11.81 20 236250 601 42384464
Coronary artery stenosis 18.62 11.81 18 236252 10361 42374704
Encephalitis 18.56 11.81 100 236170 9058 42376007
Disease susceptibility 18.43 11.81 9 236261 72 42384993
Emotional disorder 18.42 11.81 6 236264 6308 42378757
Acute respiratory distress syndrome 18.34 11.81 251 236019 29857 42355208
Dementia 18.33 11.81 40 236230 16440 42368625
Lymphadenitis viral 18.29 11.81 7 236263 28 42385037
Cardiac disorder 18.29 11.81 178 236092 48754 42336311
Superinfection bacterial 18.26 11.81 30 236240 1374 42383691
Infective exacerbation of chronic obstructive airways disease 18.26 11.81 37 236233 1996 42383069
Drug dose omission by device 18.25 11.81 5 236265 5881 42379184
Blood test abnormal 18.24 11.81 27 236243 12879 42372186
Hyperhidrosis 18.18 11.81 373 235897 90139 42294926
Metastases to spleen 18.18 11.81 18 236252 491 42384574
Intestinal obstruction 18.14 11.81 83 236187 27075 42357990
Left ventricular hypertrophy 18.11 11.81 15 236255 9304 42375761
Therapeutic response decreased 18.04 11.81 297 235973 36715 42348350
Central nervous system fungal infection 18.02 11.81 17 236253 436 42384629
Candida pneumonia 17.98 11.81 22 236248 764 42384301
Allergic fungal rhinosinusitis 17.90 11.81 8 236262 51 42385014
Steroid diabetes 17.88 11.81 45 236225 2807 42382258
Adrenal insufficiency 17.86 11.81 50 236220 18874 42366191
Alanine aminotransferase increased 17.85 11.81 364 235906 88042 42297023
Nephrolithiasis 17.85 11.81 125 236145 36705 42348360
Aspiration 17.83 11.81 46 236224 17840 42367225
Circulatory collapse 17.79 11.81 69 236201 23567 42361498
Blister 17.78 11.81 85 236185 27405 42357660
Echo virus infection 17.77 11.81 6 236264 15 42385050
Pneumonia acinetobacter 17.72 11.81 13 236257 232 42384833
Vascular device infection 17.71 11.81 74 236196 6036 42379029
Hypertriglyceridaemia 17.66 11.81 18 236252 10108 42374957
Bone marrow disorder 17.66 11.81 36 236234 1950 42383115
Plasma cell myeloma recurrent 17.65 11.81 5 236265 5752 42379313
Critical illness 17.63 11.81 13 236257 234 42384831
Faeces soft 17.61 11.81 3 236267 4909 42380156
Pulmonary hypertension 17.61 11.81 69 236201 23500 42361565
Cytomegalovirus enteritis 17.61 11.81 20 236250 641 42384424
Eye pain 17.60 11.81 43 236227 16987 42368078
Intestinal atresia 17.53 11.81 9 236261 81 42384984
Giant cell arteritis 17.51 11.81 27 236243 1171 42383894
Pulmonary nocardiosis 17.50 11.81 34 236236 1778 42383287
Oral pruritus 17.45 11.81 18 236252 516 42384549
Coronavirus infection 17.40 11.81 66 236204 5148 42379917
Dysuria 17.40 11.81 101 236169 30995 42354070
Back disorder 17.39 11.81 10 236260 7504 42377561
Isosporiasis 17.39 11.81 10 236260 115 42384950
Blood loss anaemia 17.34 11.81 17 236253 9719 42375346
Hepatitis C RNA increased 17.25 11.81 14 236256 292 42384773
Apnoea 17.20 11.81 11 236259 7792 42377273
Meningitis tuberculous 17.17 11.81 20 236250 659 42384406
Gastrooesophageal reflux disease 17.15 11.81 163 236107 44860 42340205
Ventricular hypertrophy 17.14 11.81 3 236267 4813 42380252
Pain in jaw 17.14 11.81 34 236236 14468 42370597
Autoimmune hepatitis 17.13 11.81 5 236265 5640 42379425
Productive cough 17.07 11.81 193 236077 51374 42333691
Metastases to liver 17.04 11.81 41 236229 16285 42368780
Drug reaction with eosinophilia and systemic symptoms 17.04 11.81 150 236120 41925 42343140
Dialysis 17.01 11.81 25 236245 11961 42373104
Neutropenic colitis 16.97 11.81 59 236211 4411 42380654
Herpes oesophagitis 16.91 11.81 11 236259 160 42384905
Peripheral coldness 16.88 11.81 13 236257 8362 42376703
Bladder cancer 16.87 11.81 44 236226 17003 42368062
Anosmia 16.81 11.81 4 236266 5172 42379893
Affective disorder 16.81 11.81 6 236264 5954 42379111
West Nile viral infection 16.80 11.81 23 236247 894 42384171
Phospholipase A2 activity increased 16.80 11.81 4 236266 0 42385065
Human anti-mouse antibody positive 16.80 11.81 4 236266 0 42385065
Subclavian vein thrombosis 16.79 11.81 24 236246 972 42384093
Blood HIV RNA increased 16.79 11.81 31 236239 1560 42383505
Eating disorder 16.76 11.81 18 236252 9867 42375198
Encephalitis Japanese B 16.75 11.81 6 236264 19 42385046
Red blood cell sedimentation rate 16.72 11.81 25 236245 1055 42384010
Neutrophil Pelger-Huet anomaly present 16.68 11.81 13 236257 255 42384810
Red blood cell sedimentation rate abnormal 16.67 11.81 53 236217 3783 42381282
Obesity 16.66 11.81 42 236228 16417 42368648
Hepatic amoebiasis 16.60 11.81 8 236262 62 42385003
Blood triglycerides increased 16.53 11.81 40 236230 15856 42369209
Staphylococcal infection 16.52 11.81 297 235973 37346 42347719
Procalcitonin increased 16.52 11.81 38 236232 2238 42382827
Urethral obstruction 16.42 11.81 12 236258 213 42384852
Seminoma 16.40 11.81 14 236256 314 42384751
Angiolymphoid hyperplasia with eosinophilia 16.34 11.81 10 236260 130 42384935
Tubulointerstitial nephritis 16.33 11.81 105 236165 31443 42353622
Cutaneous mucormycosis 16.31 11.81 19 236251 626 42384439
Biliary fistula 16.31 11.81 9 236261 95 42384970
Paresis 16.30 11.81 40 236230 2456 42382609
Granulocytopenia neonatal 16.30 11.81 6 236264 21 42385044
Varicella zoster virus infection 16.27 11.81 41 236229 2560 42382505
Renal tubular atrophy 16.18 11.81 29 236241 1426 42383639
Carotid artery stenosis 16.15 11.81 5 236265 5431 42379634
Superior mesenteric artery syndrome 16.15 11.81 9 236261 97 42384968
Cellulitis gangrenous 16.14 11.81 13 236257 268 42384797
Benign prostatic hyperplasia 16.13 11.81 61 236209 20991 42364074
Meningoencephalitis viral 16.13 11.81 11 236259 174 42384891
Acute hepatic failure 16.11 11.81 155 236115 16918 42368147
Device difficult to use 16.06 11.81 3 236267 4593 42380472
Aortitis 16.05 11.81 19 236251 637 42384428
Borrelia infection 15.97 11.81 8 236262 68 42384997
Ocular hyperaemia 15.95 11.81 41 236229 15922 42369143
Helicobacter sepsis 15.88 11.81 6 236264 23 42385042
Nodular regenerative hyperplasia 15.86 11.81 24 236246 1024 42384041
Fine motor skill dysfunction 15.83 11.81 37 236233 2202 42382863
Cataract 15.83 11.81 248 236022 30356 42354709
Ascites 15.81 11.81 220 236050 56458 42328607
Epstein-Barr virus associated lymphoproliferative disorder 15.80 11.81 39 236231 2404 42382661
Ecthyma 15.77 11.81 19 236251 649 42384416
Central nervous system infection 15.75 11.81 22 236248 872 42384193
Drug eruption 15.72 11.81 70 236200 23005 42362060
Brain natriuretic peptide increased 15.68 11.81 9 236261 6761 42378304
Vitamin D decreased 15.67 11.81 3 236267 4512 42380553
Tularaemia 15.65 11.81 11 236259 183 42384882
Combined immunodeficiency 15.61 11.81 9 236261 104 42384961
Leukaemia cutis 15.58 11.81 8 236262 72 42384993
Jaundice 15.51 11.81 120 236150 34469 42350596
Giardiasis 15.49 11.81 17 236253 524 42384541
Full blood count decreased 15.48 11.81 60 236210 20500 42364565
Osteoporosis 15.41 11.81 138 236132 14768 42370297
Rheumatoid factor 15.40 11.81 8 236262 74 42384991
Stevens-Johnson syndrome 15.28 11.81 67 236203 22111 42362954
Migraine with aura 15.28 11.81 22 236248 897 42384168
Norovirus infection 15.22 11.81 20 236250 747 42384318
Acidosis 15.20 11.81 28 236242 12251 42372814
Gastrointestinal pain 15.18 11.81 3 236267 4412 42380653
Herpes virus infection 15.13 11.81 50 236220 3642 42381423
Lymph node haemorrhage 15.13 11.81 6 236264 27 42385038
Blood 1,25-dihydroxycholecalciferol increased 15.13 11.81 6 236264 27 42385038
Neurofibrosarcoma 15.12 11.81 7 236263 49 42385016
Tooth disorder 15.12 11.81 116 236154 11863 42373202
Psychomotor skills impaired 15.09 11.81 5 236265 5199 42379866
Kidney fibrosis 15.07 11.81 41 236229 2681 42382384
Limb discomfort 15.03 11.81 30 236240 12737 42372328
Upper limb fracture 14.99 11.81 6 236264 5550 42379515
Haemodialysis 14.96 11.81 21 236249 10239 42374826
Parasitic gastroenteritis 14.94 11.81 10 236260 153 42384912
Gastritis 14.93 11.81 75 236195 23872 42361193
Bone cyst 14.77 11.81 30 236240 1621 42383444
Focal segmental glomerulosclerosis 14.74 11.81 39 236231 2509 42382556
Clostridium difficile infection 14.67 11.81 191 236079 22468 42362597
Dizziness postural 14.60 11.81 13 236257 7782 42377283
Factor VIII inhibition 14.60 11.81 13 236257 309 42384756
Meningoradiculitis 14.55 11.81 7 236263 54 42385011
Pain of skin 14.51 11.81 14 236256 8066 42376999
Type III immune complex mediated reaction 14.48 11.81 17 236253 565 42384500
Paraesthesia ear 14.46 11.81 6 236264 31 42385034
Platelet distribution width decreased 14.46 11.81 6 236264 31 42385034
Phlebitis infective 14.44 11.81 9 236261 121 42384944
Alanine aminotransferase abnormal 14.42 11.81 60 236210 4884 42380181
B-cell small lymphocytic lymphoma recurrent 14.41 11.81 5 236265 14 42385051
Retroperitoneal fibrosis 14.35 11.81 15 236255 437 42384628
Pemphigoid 14.33 11.81 26 236244 11441 42373624
Muscular weakness 14.24 11.81 353 235917 83145 42301920
Fibrosis 14.22 11.81 43 236227 2987 42382078
Pneumonia cryptococcal 14.21 11.81 28 236242 1480 42383585
Leukaemic infiltration 14.20 11.81 10 236260 167 42384898
Chronic hepatitis B 14.19 11.81 9 236261 125 42384940
Quality of life decreased 14.19 11.81 6 236264 5370 42379695
Viral cardiomyopathy 14.16 11.81 6 236264 33 42385032
Gallbladder adenocarcinoma 14.16 11.81 5 236265 15 42385050
Glottis carcinoma 14.16 11.81 5 236265 15 42385050
Blood glucose abnormal 14.15 11.81 11 236259 7042 42378023
Oropharyngeal squamous cell carcinoma 14.13 11.81 12 236258 267 42384798
Personality change 14.13 11.81 7 236263 5712 42379353
Disseminated strongyloidiasis 14.13 11.81 16 236254 511 42384554
Hepatitis D 14.13 11.81 7 236263 58 42385007
Carotid artery occlusion 14.11 11.81 3 236267 4191 42380874
Injection site rash 14.10 11.81 7 236263 5705 42379360
Cubital tunnel syndrome 14.07 11.81 11 236259 217 42384848
Reticulocytopenia 14.05 11.81 10 236260 170 42384895
Infective aortitis 14.01 11.81 6 236264 34 42385031
Plateletcrit decreased 14.01 11.81 6 236264 34 42385031
Hepatitis viral 14.01 11.81 20 236250 809 42384256
Erythema 14.01 11.81 478 235792 108315 42276750
Ocular lymphoma 13.99 11.81 8 236262 91 42384974
Skin neoplasm bleeding 13.92 11.81 5 236265 16 42385049
Glossodynia 13.91 11.81 3 236267 4149 42380916
Dry eye 13.88 11.81 42 236228 15464 42369601
Gastroenteritis viral 13.82 11.81 15 236255 8184 42376881
Vitamin B12 deficiency 13.80 11.81 5 236265 4917 42380148
Gastric stenosis 13.77 11.81 9 236261 132 42384933
Skin haemorrhage 13.77 11.81 14 236256 7871 42377194
Mycobacterium chelonae infection 13.77 11.81 24 236246 1154 42383911
Central nervous system neoplasm 13.76 11.81 8 236262 94 42384971
Fat tissue increased 13.72 11.81 16 236254 528 42384537
Choking 13.71 11.81 9 236261 6289 42378776
Immobilisation syndrome 13.71 11.81 15 236255 461 42384604
Metabolic encephalopathy 13.70 11.81 6 236264 5259 42379806
Cerebral haematoma 13.66 11.81 7 236263 5603 42379462
Listeria encephalitis 13.64 11.81 7 236263 63 42385002
Transformation to acute myeloid leukaemia 13.56 11.81 23 236247 1082 42383983
Soft tissue disorder 13.55 11.81 20 236250 834 42384231
Hypovolaemia 13.51 11.81 27 236243 11458 42373607
Diffuse large B-cell lymphoma stage IV 13.50 11.81 16 236254 537 42384528
Apathy 13.50 11.81 16 236254 8390 42376675
Cystitis noninfective 13.48 11.81 16 236254 538 42384527
Bacillus bacteraemia 13.47 11.81 10 236260 182 42384883
Hepatitis cholestatic 13.45 11.81 21 236249 9803 42375262
Injection site extravasation 13.44 11.81 43 236227 3079 42381986
Muscle abscess 13.41 11.81 21 236249 923 42384142
Myeloid leukaemia 13.40 11.81 15 236255 473 42384592
Central nervous system lesion 13.38 11.81 82 236188 7788 42377277
Anaphylactic shock 13.36 11.81 76 236194 23441 42361624
Granuloma 13.36 11.81 51 236219 3990 42381075
Pulmonary toxicity 13.36 11.81 88 236182 8567 42376498
Thinking abnormal 13.34 11.81 12 236258 7149 42377916
Lymphocytic lymphoma 13.33 11.81 6 236264 39 42385026
Engraftment syndrome 13.33 11.81 26 236244 1364 42383701
Bile duct necrosis 13.27 11.81 7 236263 67 42384998
Antithrombin III deficiency 13.27 11.81 9 236261 141 42384924
Weight decreased 13.22 11.81 983 235287 206965 42178100
Spirometry abnormal 13.17 11.81 6 236264 5140 42379925
Follicle centre lymphoma, follicular grade I, II, III recurrent 13.17 11.81 4 236266 6 42385059
Interchange of vaccine products 13.17 11.81 4 236266 6 42385059
Vasculitis 13.17 11.81 158 236112 18236 42366829
Sarcoid-like reaction 13.14 11.81 8 236262 103 42384962
Haemophilus test positive 13.14 11.81 8 236262 103 42384962
Pulmonary mass 13.12 11.81 143 236127 16122 42368943
Bundle branch block left 13.12 11.81 10 236260 6466 42378599
Mucocutaneous haemorrhage 13.11 11.81 9 236261 144 42384921
Dysphagia 13.07 11.81 305 235965 72414 42312651
Infected skin ulcer 13.03 11.81 32 236238 1966 42383099
Cytomegalovirus gastrointestinal ulcer 13.00 11.81 8 236262 105 42384960
Nocturia 12.98 11.81 30 236240 12082 42372983
Toxic leukoencephalopathy 12.97 11.81 18 236252 709 42384356
Biliary abscess 12.96 11.81 6 236264 42 42385023
Peripheral blood stem cell apheresis 12.95 11.81 9 236261 147 42384918
Nasal congestion 12.93 11.81 103 236167 29398 42355667
Generalised oedema 12.92 11.81 136 236134 15200 42369865
Malignant transformation 12.86 11.81 21 236249 957 42384108
Cardiovascular disorder 12.85 11.81 35 236235 13330 42371735
Cardiac sarcoidosis 12.84 11.81 9 236261 149 42384916
Morphoea 12.83 11.81 11 236259 248 42384817
X-ray abnormal 12.81 11.81 15 236255 497 42384568
Tooth hypoplasia 12.80 11.81 11 236259 249 42384816
Hepatitis fulminant 12.80 11.81 58 236212 4901 42380164
Gingival pain 12.77 11.81 17 236253 8477 42376588
Meningitis aseptic 12.77 11.81 54 236216 4428 42380637
Disseminated cryptococcosis 12.73 11.81 31 236239 1894 42383171
Necrotic lymphadenopathy 12.73 11.81 6 236264 44 42385021
Atypical fibroxanthoma 12.71 11.81 10 236260 199 42384866
Testicular seminoma (pure) 12.71 11.81 10 236260 199 42384866
Tinnitus 12.70 11.81 101 236169 28837 42356228
High density lipoprotein decreased 12.68 11.81 3 236267 3894 42381171
Positron emission tomogram abnormal 12.67 11.81 10 236260 200 42384865
Laboratory test abnormal 12.66 11.81 75 236195 22903 42362162
Immunoglobulin G4 related disease 12.65 11.81 11 236259 253 42384812
Cytokine storm 12.63 11.81 20 236250 888 42384177
Hypothermia 12.62 11.81 32 236238 12483 42372582
Hepatitis B core antigen positive 12.60 11.81 3 236267 0 42385065
Splenic infection 12.60 11.81 3 236267 0 42385065
Follicular lymphoma stage IV 12.60 11.81 3 236267 0 42385065
Echovirus test positive 12.60 11.81 3 236267 0 42385065
Lower respiratory tract herpes infection 12.60 11.81 3 236267 0 42385065
Hypercapnia 12.60 11.81 7 236263 5354 42379711
Product use issue 12.60 11.81 533 235737 76218 42308847
Hepatic infection fungal 12.58 11.81 11 236259 255 42384810
Transplant dysfunction 12.58 11.81 44 236226 3299 42381766
Respiratory acidosis 12.54 11.81 10 236260 6321 42378744
Osteolysis 12.52 11.81 46 236224 3534 42381531
Granulocytes maturation arrest 12.52 11.81 5 236265 23 42385042
Multiple sclerosis relapse 12.51 11.81 39 236231 14225 42370840
Cardiac infection 12.51 11.81 11 236259 257 42384808
Gastrointestinal neoplasm 12.51 11.81 11 236259 257 42384808
Sphingomonas paucimobilis infection 12.50 11.81 6 236264 46 42385019
Musculoskeletal disorder 12.47 11.81 71 236199 6567 42378498
Total complement activity decreased 12.45 11.81 4 236266 8 42385057
Hypercalcaemia 12.45 11.81 154 236116 17904 42367161
Hepatosplenomegaly 12.40 11.81 55 236215 4605 42380460
Tongue pruritus 12.39 11.81 6 236264 47 42385018
Abdominal neoplasm 12.39 11.81 14 236256 446 42384619
C3 glomerulopathy 12.35 11.81 9 236261 159 42384906
Non-Hodgkin's lymphoma recurrent 12.35 11.81 5 236265 24 42385041
Tricuspid valve incompetence 12.34 11.81 27 236243 11086 42373979
Spinal operation 12.33 11.81 4 236266 4216 42380849
Movement disorder 12.32 11.81 41 236229 14657 42370408
Catheter site thrombosis 12.30 11.81 9 236261 160 42384905
Blood glucose fluctuation 12.30 11.81 5 236265 4582 42380483
Lymph node palpable 12.29 11.81 6 236264 48 42385017
Jugular vein thrombosis 12.25 11.81 32 236238 2042 42383023
Electrocardiogram ST segment elevation 12.25 11.81 9 236261 5930 42379135
Squamous cell carcinoma of skin 12.24 11.81 116 236154 12610 42372455
Rash pruritic 12.23 11.81 123 236147 33480 42351585
Jejunal perforation 12.22 11.81 12 236258 324 42384741
Recurrent cancer 12.21 11.81 28 236242 1645 42383420
Infective thrombosis 12.21 11.81 7 236263 80 42384985
Hip arthroplasty 12.20 11.81 60 236210 5245 42379820
Mantle cell lymphoma stage III 12.18 11.81 5 236265 25 42385040
Lacrimal duct neoplasm 12.18 11.81 5 236265 25 42385040
Pseudomonas aeruginosa meningitis 12.18 11.81 6 236264 49 42385016
Hepatitis C 12.17 11.81 97 236173 10036 42375029
CD4 lymphocyte percentage decreased 12.14 11.81 4 236266 9 42385056
Wrong product administered 12.13 11.81 10 236260 6216 42378849
Blood testosterone decreased 12.11 11.81 6 236264 4896 42380169
Monocyte count increased 12.11 11.81 63 236207 5631 42379434
Infection reactivation 12.10 11.81 33 236237 2161 42382904
Tumour obstruction 12.06 11.81 7 236263 82 42384983
Faciobrachial dystonic seizure 12.06 11.81 7 236263 82 42384983
Granulomatosis with polyangiitis 12.05 11.81 26 236244 1466 42383599
Gastrointestinal lymphoma 12.03 11.81 8 236262 121 42384944
Myelodysplastic syndrome unclassifiable 12.03 11.81 8 236262 121 42384944
Myeloid maturation arrest 12.03 11.81 5 236265 26 42385039
Granulomatous lymphadenitis 12.03 11.81 10 236260 216 42384849
Erythropoiesis abnormal 12.01 11.81 12 236258 331 42384734
Lymphoproliferative disorder 11.99 11.81 43 236227 3264 42381801
Hypoxic-ischaemic encephalopathy 11.93 11.81 7 236263 5195 42379870
Cell-mediated immune deficiency 11.92 11.81 7 236263 84 42384981
Feeling jittery 11.90 11.81 5 236265 4493 42380572
Urticaria 11.89 11.81 513 235757 73523 42311542
Blood phosphorus increased 11.89 11.81 33 236237 12492 42372573
Pneumococcal infection 11.86 11.81 15 236255 539 42384526
Insurance issue 11.85 11.81 4 236266 4112 42380953

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 6266.55 11.47 25472 830357 1474713 108258757
Infusion related reaction 2360.22 11.47 7392 848437 373770 109359700
No adverse event 2243.33 11.47 2812 853017 71027 109662443
Drug interaction 1962.55 11.47 710 855119 499473 109233997
Completed suicide 1771.50 11.47 19 855810 242362 109491108
Contraindicated product administered 1698.50 11.47 4989 850840 243278 109490192
Drug intolerance 1694.15 11.47 6926 848903 399586 109333884
Treatment failure 1658.01 11.47 5315 850514 271919 109461551
Toxicity to various agents 1616.23 11.47 852 854977 479703 109253767
Synovitis 1602.18 11.47 5214 850615 268878 109464592
Progressive multifocal leukoencephalopathy 1486.53 11.47 1359 854470 23597 109709873
Hypogammaglobulinaemia 1450.24 11.47 1220 854609 18856 109714614
Drug ineffective 1444.76 11.47 18008 837821 1502532 108230938
Drug effective for unapproved indication 1333.98 11.47 1006 854823 13161 109720309
Drug abuse 1330.09 11.47 7 855822 177404 109556066
Joint swelling 1312.56 11.47 6828 849001 436017 109297453
Intentional product use issue 1242.60 11.47 4481 851348 243425 109490045
Hand deformity 1236.35 11.47 4112 851717 214394 109519076
Pemphigus 1193.64 11.47 4015 851814 210555 109522915
Diffuse large B-cell lymphoma recurrent 1192.83 11.47 692 855137 5607 109727863
Product dose omission issue 1173.79 11.47 510 855319 321272 109412198
Arthropathy 1122.41 11.47 4804 851025 282718 109450752
Glossodynia 1047.78 11.47 3936 851893 218068 109515402
Systemic lupus erythematosus 1044.31 11.47 4316 851513 250022 109483448
Anti-cyclic citrullinated peptide antibody positive 1011.72 11.47 3405 852424 178579 109554891
Therapeutic product effect decreased 984.25 11.47 4122 851707 240194 109493276
Intentional overdose 974.38 11.47 9 855820 132492 109600978
Disease progression 951.07 11.47 4076 851753 239958 109493512
Febrile neutropenia 948.54 11.47 4900 850929 311867 109421603
Acute kidney injury 903.06 11.47 2262 853567 633168 109100302
Pericarditis 863.92 11.47 3673 852156 215441 109518029
Rheumatoid factor positive 845.03 11.47 2588 853241 129052 109604418
Fall 842.94 11.47 2167 853662 601315 109132155
COVID-19 812.10 11.47 3902 851927 241158 109492312
Wound 807.54 11.47 3775 852054 230662 109502808
Injection site pain 805.50 11.47 193 855636 177729 109555741
Infection 801.89 11.47 5171 850658 357029 109376441
Hepatic enzyme increased 790.42 11.47 4709 851120 316183 109417287
Rhabdomyolysis 772.65 11.47 38 855791 120363 109613107
Hepatitis B reactivation 748.31 11.47 551 855278 6933 109726537
Helicobacter infection 742.69 11.47 3082 852747 178795 109554675
Somnolence 723.55 11.47 740 855089 296709 109436761
Throat irritation 719.25 11.47 1400 854429 52152 109681318
Duodenal ulcer perforation 708.22 11.47 2989 852840 174711 109558759
Swelling 690.21 11.47 4867 850962 346174 109387296
Hyponatraemia 670.93 11.47 428 855401 217225 109516245
Constipation 661.54 11.47 1093 854736 356693 109376777
COVID-19 pneumonia 661.39 11.47 1098 854731 36045 109697425
Dehydration 658.91 11.47 714 855115 278797 109454673
Pneumocystis jirovecii pneumonia 650.83 11.47 1179 854650 41556 109691914
Ill-defined disorder 631.73 11.47 2647 853182 154206 109579264
Hepatitis B 628.89 11.47 552 855277 9060 109724410
Suicide attempt 617.42 11.47 48 855781 103346 109630124
Folliculitis 616.76 11.47 2753 853076 164900 109568570
Diarrhoea 615.45 11.47 5749 850080 1133756 108599714
Cytomegalovirus infection 604.63 11.47 1316 854513 53128 109680342
Electrocardiogram QT prolonged 599.36 11.47 70 855759 108890 109624580
Hypersensitivity 584.27 11.47 5219 850610 398779 109334691
Overdose 579.50 11.47 572 855257 233222 109500248
Hypoglycaemia 564.19 11.47 107 855722 115997 109617473
Alopecia 561.17 11.47 4777 851052 359976 109373494
Drug hypersensitivity 546.94 11.47 5644 850185 448446 109285024
Tumour lysis syndrome 542.36 11.47 906 854923 29895 109703575
Muscle injury 537.45 11.47 2338 853491 138469 109595001
Red blood cell sedimentation rate increased 526.41 11.47 1565 854264 76737 109656733
Irritable bowel syndrome 524.47 11.47 2588 853241 161627 109571843
Blood pressure diastolic abnormal 514.09 11.47 803 855026 25012 109708458
International normalised ratio increased 494.47 11.47 49 855780 86723 109646747
Bradycardia 494.22 11.47 295 855534 155222 109578248
Ear pruritus 491.24 11.47 425 855404 6835 109726635
Blood pressure fluctuation 491.19 11.47 1483 854346 73341 109660129
Death 489.20 11.47 3283 852546 695586 109037884
Cardio-respiratory arrest 480.38 11.47 149 855680 115687 109617783
C-reactive protein abnormal 473.37 11.47 2125 853704 127570 109605900
Seizure 470.96 11.47 612 855217 220573 109512897
Blood pressure systolic abnormal 467.31 11.47 753 855076 24097 109709373
Hypotension 462.47 11.47 2282 853547 521567 109211903
Depressed level of consciousness 450.47 11.47 153 855676 112125 109621345
Musculoskeletal stiffness 446.76 11.47 3696 852133 276126 109457344
Cardiac arrest 443.48 11.47 521 855308 196232 109537238
Suicidal ideation 440.91 11.47 94 855735 93843 109639627
Hallucination 437.97 11.47 121 855708 101311 109632159
Nausea 436.15 11.47 6837 848992 1228853 108504617
Impaired healing 434.42 11.47 2808 853021 193909 109539561
Myalgia 433.90 11.47 655 855174 221726 109511744
Cytokine release syndrome 431.34 11.47 1361 854468 68945 109664525
Coma 427.55 11.47 188 855641 117681 109615789
Haematochezia 427.42 11.47 179 855650 115345 109618125
Abdominal discomfort 423.72 11.47 4787 851042 389071 109344399
Sedation 422.75 11.47 30 855799 69653 109663817
Rheumatic fever 417.41 11.47 1968 853861 120611 109612859
Agitation 416.93 11.47 176 855653 112875 109620595
Neutropenia 415.64 11.47 4581 851248 370039 109363431
Metabolic acidosis 410.57 11.47 130 855699 99614 109633856
Myelodysplastic syndrome 405.92 11.47 897 854932 36587 109696883
Cytomegalovirus infection reactivation 405.74 11.47 599 855230 17734 109715736
Drug ineffective for unapproved indication 404.23 11.47 1723 854106 101115 109632355
Dry skin 399.58 11.47 166 855663 107487 109625983
Inflammation 399.27 11.47 2713 853116 190525 109542945
Discomfort 397.37 11.47 2935 852894 211772 109521698
Cardiac failure congestive 395.79 11.47 351 855478 150649 109582821
Injection site erythema 394.37 11.47 119 855710 94057 109639413
Dizziness 394.31 11.47 3480 852349 694713 109038757
Hyperkalaemia 382.73 11.47 294 855535 135502 109597968
C-reactive protein increased 378.61 11.47 2935 852894 214984 109518486
Serum sickness 371.37 11.47 293 855536 4113 109729357
Sleep disorder due to general medical condition, insomnia type 371.37 11.47 1712 854117 103931 109629539
Myocardial infarction 368.70 11.47 572 855257 191511 109541959
Type 2 diabetes mellitus 364.77 11.47 2486 853343 174746 109558724
Feeling abnormal 358.59 11.47 526 855303 180185 109553285
Wrong technique in product usage process 357.46 11.47 115 855714 87233 109646237
Lactic acidosis 346.26 11.47 142 855687 92669 109640801
Fibromyalgia 345.61 11.47 2387 853442 168522 109564948
Joint range of motion decreased 345.05 11.47 1857 853972 119975 109613495
Product use issue 344.43 11.47 3809 852020 307886 109425584
Blood pressure systolic increased 339.80 11.47 1408 854421 81583 109651887
Serotonin syndrome 332.89 11.47 35 855794 59118 109674352
Disease recurrence 331.86 11.47 1131 854698 59653 109673817
Incorrect dose administered 331.51 11.47 195 855634 103446 109630024
Vision blurred 330.87 11.47 306 855523 128716 109604754
Maternal exposure during pregnancy 329.51 11.47 3216 852613 251667 109481803
Loss of consciousness 328.98 11.47 637 855192 195669 109537801
Swollen joint count increased 325.15 11.47 1397 854432 82264 109651206
Psoriatic arthropathy 320.92 11.47 2612 853217 194149 109539321
Bursitis 307.54 11.47 1888 853941 128030 109605440
Lower respiratory tract infection 302.86 11.47 3044 852785 240062 109493408
B-lymphocyte count decreased 302.19 11.47 192 855637 1863 109731607
Plasma cell myeloma 301.52 11.47 60 855769 62876 109670594
Angioedema 300.26 11.47 196 855633 98304 109635166
Cytopenia 299.74 11.47 697 855132 29419 109704051
Accidental overdose 298.68 11.47 28 855801 51806 109681664
Syncope 297.95 11.47 707 855122 201829 109531641
Blister 297.34 11.47 2876 852953 224500 109508970
Injection site swelling 295.83 11.47 59 855770 61731 109671739
Therapy non-responder 295.32 11.47 2158 853671 155149 109578321
Tremor 294.28 11.47 710 855119 201522 109531948
Post transplant lymphoproliferative disorder 293.42 11.47 473 855356 15140 109718330
Gastrointestinal disorder 291.58 11.47 3009 852820 238943 109494527
Respiratory arrest 289.08 11.47 51 855778 58248 109675222
Blood creatine phosphokinase increased 287.24 11.47 103 855726 72974 109660496
Facet joint syndrome 285.18 11.47 1492 854337 95336 109638134
Abdominal pain 283.53 11.47 2570 853259 510419 109223051
Dyspnoea 281.50 11.47 6475 849354 1100397 108633073
Aggression 280.43 11.47 58 855771 59152 109674318
Stomatitis 277.99 11.47 3257 852572 266985 109466485
Agranulocytosis 277.78 11.47 1079 854750 60681 109672789
Unresponsive to stimuli 277.43 11.47 75 855754 63715 109669755
Diffuse large B-cell lymphoma refractory 275.74 11.47 196 855633 2325 109731145
Cerebrovascular accident 275.36 11.47 622 855207 180662 109552808
Product use in unapproved indication 274.14 11.47 4925 850904 442452 109291018
Lip dry 273.61 11.47 1511 854318 98572 109634898
Humoral immune defect 273.29 11.47 128 855701 625 109732845
Orthostatic hypotension 273.26 11.47 86 855743 66163 109667307
Lymphoma 269.17 11.47 526 855303 19645 109713825
Anaemia 269.03 11.47 2820 853009 544266 109189204
Therapy partial responder 268.54 11.47 761 855068 36300 109697170
Chronic lymphocytic leukaemia recurrent 266.79 11.47 140 855689 909 109732561
Drug withdrawal syndrome 265.18 11.47 6 855823 38048 109695422
Coeliac disease 264.84 11.47 836 854993 42351 109691119
Rheumatoid nodule 262.07 11.47 522 855307 19774 109713696
Mobility decreased 261.07 11.47 2899 852930 234523 109498947
Gastrointestinal haemorrhage 259.54 11.47 558 855271 164960 109568510
Coronary artery disease 254.25 11.47 118 855711 71572 109661898
Hypokalaemia 254.17 11.47 655 855174 181793 109551677
Accidental exposure to product 254.03 11.47 41 855788 49967 109683503
Blood cholesterol increased 253.83 11.47 2362 853467 182423 109551047
Intentional self-injury 252.99 11.47 8 855821 37421 109696049
Grip strength decreased 251.88 11.47 1258 854571 78916 109654554
Wound infection 251.53 11.47 1438 854391 95027 109638443
Oedema peripheral 249.36 11.47 1505 854324 327155 109406315
Osteoarthritis 249.17 11.47 2331 853498 180292 109553178
Dyskinesia 248.65 11.47 48 855781 51398 109682072
B-cell lymphoma recurrent 248.31 11.47 138 855691 1020 109732450
Back pain 248.05 11.47 1765 854064 369231 109364239
Nightmare 246.96 11.47 13 855816 38850 109694620
Pulmonary fibrosis 239.65 11.47 1480 854349 100562 109632908
Vomiting 239.56 11.47 5298 850531 905377 108828093
Hospitalisation 239.04 11.47 462 855367 142031 109591439
Dysgeusia 237.86 11.47 122 855707 69863 109663607
Epistaxis 237.22 11.47 402 855427 129970 109603500
Intentional product misuse 236.18 11.47 416 855413 132488 109600982
Sopor 236.15 11.47 11 855818 36535 109696935
Haematotoxicity 235.63 11.47 511 855318 20571 109712899
Therapy interrupted 235.55 11.47 49 855780 49773 109683697
Injection site pruritus 235.06 11.47 54 855775 51204 109682266
Nasopharyngitis 232.62 11.47 4316 851513 390045 109343425
Disorientation 231.68 11.47 129 855700 70542 109662928
JC virus infection 230.74 11.47 243 855586 5047 109728423
Lethargy 230.51 11.47 230 855599 93346 109640124
Urinary tract infection 230.11 11.47 1528 854301 324754 109408716
Eczema 229.81 11.47 137 855692 72156 109661314
Swelling face 228.47 11.47 226 855603 92095 109641375
Diabetic ketoacidosis 224.01 11.47 30 855799 42028 109691442
Haematemesis 217.95 11.47 92 855737 59016 109674454
Liver injury 216.37 11.47 1942 853887 148471 109584999
Full blood count abnormal 215.25 11.47 82 855747 55970 109677500
Obstructive airways disorder 214.88 11.47 47 855782 46102 109687368
Sciatica 213.13 11.47 1334 854495 91065 109642405
Therapy cessation 212.31 11.47 44 855785 44813 109688657
Device issue 212.01 11.47 14 855815 34521 109698949
Myelosuppression 212.01 11.47 1353 854476 92987 109640483
Vaccination failure 211.97 11.47 167 855662 2339 109731131
Acute myocardial infarction 210.89 11.47 202 855627 83575 109649895
Epstein-Barr virus infection 210.36 11.47 455 855374 18283 109715187
Bone erosion 210.04 11.47 812 855017 45559 109687911
Peripheral venous disease 207.66 11.47 1236 854593 82881 109650589
Palmar-plantar erythrodysaesthesia syndrome 207.57 11.47 34 855795 40991 109692479
Breast cancer stage III 203.38 11.47 1175 854654 77942 109655528
Swollen tongue 202.51 11.47 107 855722 60255 109673215
Aspergillus infection 202.46 11.47 543 855286 25073 109708397
Hallucination, visual 199.99 11.47 33 855796 39572 109693898
Lip swelling 199.83 11.47 71 855758 50596 109682874
Labelled drug-drug interaction medication error 199.00 11.47 6 855823 29296 109704174
Urinary retention 198.70 11.47 149 855680 69534 109663936
Mantle cell lymphoma recurrent 197.68 11.47 114 855715 912 109732558
Sinusitis 197.33 11.47 3310 852519 293378 109440092
Chronic obstructive pulmonary disease 197.30 11.47 338 855491 108820 109624650
Emotional distress 196.40 11.47 52 855777 44795 109688675
Mental status changes 195.78 11.47 180 855649 75942 109657528
Vertigo 195.69 11.47 230 855599 86640 109646830
Transient ischaemic attack 195.42 11.47 127 855702 63855 109669615
Flatulence 194.17 11.47 80 855749 52069 109681401
Hypomagnesaemia 192.46 11.47 114 855715 60256 109673214
Diffuse large B-cell lymphoma 192.33 11.47 398 855431 15500 109717970
Extrapyramidal disorder 192.18 11.47 7 855822 28860 109704610
Blood glucose increased 191.26 11.47 467 855362 132029 109601441
Tachycardia 188.50 11.47 1007 854822 225638 109507832
Immunodeficiency 188.25 11.47 695 855134 38143 109695327
Arthralgia 187.81 11.47 7594 848235 772038 108961432
Drug tolerance decreased 187.46 11.47 553 855276 26987 109706483
Melaena 187.24 11.47 154 855675 68603 109664867
Panniculitis 186.06 11.47 388 855441 15194 109718276
Injection site haemorrhage 184.67 11.47 20 855809 33008 109700462
Granuloma skin 184.26 11.47 321 855508 10962 109722508
Balance disorder 183.50 11.47 392 855437 116168 109617302
Injury 181.98 11.47 2136 853693 175129 109558341
Osteonecrosis of jaw 181.49 11.47 72 855757 47945 109685525
Withdrawal syndrome 180.67 11.47 17 855812 31363 109702107
Blood pressure diastolic decreased 180.55 11.47 650 855179 35235 109698235
Irritability 180.19 11.47 72 855757 47737 109685733
Disturbance in attention 180.09 11.47 130 855699 61865 109671605
Anxiety 180.09 11.47 1753 854076 343325 109390145
Lung disorder 179.76 11.47 2158 853671 177889 109555581
Restlessness 179.69 11.47 106 855723 56153 109677317
Asthenia 179.02 11.47 4015 851814 684984 109048486
Dermatitis atopic 178.08 11.47 4 855825 25537 109707933
Blood parathyroid hormone decreased 175.47 11.47 342 855487 12747 109720723
Prescribed overdose 175.05 11.47 1220 854609 86361 109647109
Hyperglycaemia 169.39 11.47 247 855582 84843 109648627
Hip arthroplasty 168.45 11.47 866 854963 54947 109678523
Generalised tonic-clonic seizure 166.37 11.47 109 855720 54571 109678899
Altered state of consciousness 165.88 11.47 122 855707 57504 109675966
Impaired quality of life 165.75 11.47 19 855810 29998 109703472
Nail disorder 165.28 11.47 885 854944 57050 109676420
Oedema 164.42 11.47 2408 853421 207568 109525902
Oxygen saturation decreased 162.63 11.47 1895 853934 155087 109578383
Surgery 162.56 11.47 58 855771 41225 109692245
Dislocation of vertebra 162.16 11.47 720 855109 43001 109690469
Blood potassium decreased 161.78 11.47 110 855719 54004 109679466
Wheezing 161.53 11.47 2825 853004 252405 109481065
Night sweats 161.15 11.47 1666 854163 132317 109601153
Bronchopulmonary aspergillosis 160.65 11.47 553 855276 29310 109704160
Injection site bruising 160.35 11.47 99 855730 51164 109682306
Foot deformity 159.61 11.47 771 855058 47709 109685761
Pharyngeal paraesthesia 159.58 11.47 178 855651 3954 109729516
Poisoning 159.28 11.47 19 855810 29086 109704384
Encephalitis cytomegalovirus 158.80 11.47 126 855703 1784 109731686
Hallucination, auditory 158.29 11.47 12 855817 26385 109707085
Renal failure 158.19 11.47 1064 854765 225510 109507960
Rectal haemorrhage 157.22 11.47 443 855386 119390 109614080
Dyspnoea exertional 156.38 11.47 359 855470 103701 109629769
Gait inability 154.30 11.47 1675 854154 134701 109598769
Pulmonary oedema 153.93 11.47 344 855485 100315 109633155
Ventricular fibrillation 152.81 11.47 64 855765 41249 109692221
Blood bilirubin increased 152.74 11.47 219 855610 75753 109657717
Drug level increased 152.28 11.47 90 855739 47629 109685841
Product substitution issue 152.13 11.47 6 855823 23055 109710415
Abnormal behaviour 151.77 11.47 56 855773 38983 109694487
Depressed mood 151.45 11.47 148 855681 60661 109672809
Bone marrow failure 151.20 11.47 863 854966 56985 109676485
Drug reaction with eosinophilia and systemic symptoms 150.38 11.47 252 855577 81843 109651627
Pain 149.04 11.47 8916 846913 946039 108787431
Second primary malignancy 148.88 11.47 389 855440 17679 109715791
Stress 148.38 11.47 376 855453 104972 109628498
Decreased appetite 147.33 11.47 2693 853136 473153 109260317
Ventricular tachycardia 146.40 11.47 104 855725 49905 109683565
Lymphoma transformation 146.22 11.47 78 855751 526 109732944
Myoclonus 145.00 11.47 38 855791 32960 109700510
Cholelithiasis 144.92 11.47 166 855663 63256 109670214
BK virus infection 144.56 11.47 316 855513 12790 109720680
Pancreatitis acute 144.07 11.47 152 855677 60122 109673348
Haemoptysis 143.14 11.47 206 855623 71148 109662322
Injection site mass 142.59 11.47 13 855816 24600 109708870
Pneumonia aspiration 140.95 11.47 258 855571 80975 109652495
Hepatitis E 140.42 11.47 173 855656 4286 109729184
Circulatory collapse 140.16 11.47 79 855750 42914 109690556
Blood calcium decreased 140.05 11.47 51 855778 35794 109697676
Musculoskeletal pain 139.39 11.47 2089 853740 180934 109552536
Psychotic disorder 138.81 11.47 114 855715 50823 109682647
Babesiosis 137.21 11.47 70 855759 425 109733045
Ureaplasma infection 137.21 11.47 106 855723 1440 109732030
Deep vein thrombosis postoperative 136.71 11.47 856 854973 58435 109675035
Respiratory depression 136.59 11.47 39 855790 31962 109701508
Multiple sclerosis relapse 136.21 11.47 113 855716 50127 109683343
Head injury 136.05 11.47 82 855747 42935 109690535
Unevaluable event 135.35 11.47 155 855674 59072 109674398
Nasal oedema 135.13 11.47 212 855617 6627 109726843
Finger deformity 135.07 11.47 561 855268 32531 109700939
Hypophagia 134.67 11.47 125 855704 52501 109680969
Injection site rash 134.00 11.47 13 855816 23406 109710064
Dystonia 133.70 11.47 20 855809 25785 109707685
Lower limb fracture 133.59 11.47 1020 854809 74328 109659142
Hypoxia 133.45 11.47 532 855297 128983 109604487
Hyperlipidaemia 133.45 11.47 55 855774 35793 109697677
Speech disorder 133.40 11.47 168 855661 61401 109672069
Blood alkaline phosphatase increased 132.48 11.47 215 855614 70720 109662750
Hypothyroidism 132.39 11.47 225 855604 72674 109660796
Cognitive disorder 131.42 11.47 302 855527 87209 109646261
Cerebral haemorrhage 130.88 11.47 187 855642 64781 109668689
Adjustment disorder with depressed mood 130.42 11.47 678 855151 43205 109690265
Device malfunction 129.71 11.47 21 855808 25537 109707933
Product administration error 129.29 11.47 63 855766 37154 109696316
Toxic epidermal necrolysis 129.05 11.47 149 855680 56578 109676892
Metastases to bone 128.88 11.47 41 855788 31331 109702139
Basal cell carcinoma 127.41 11.47 689 855140 44581 109688889
Muscle rigidity 125.95 11.47 18 855811 24013 109709457
Knee arthroplasty 125.85 11.47 898 854931 64050 109669420
Blood urea increased 125.40 11.47 144 855685 54813 109678657
Creatinine renal clearance decreased 125.11 11.47 12 855817 21803 109711667
Product label confusion 124.67 11.47 423 855406 22254 109711216
Therapeutic response decreased 124.26 11.47 1217 854612 95282 109638188
Obesity 124.00 11.47 1383 854446 111968 109621502
Skin exfoliation 123.32 11.47 313 855516 87338 109646132
Post-acute COVID-19 syndrome 122.66 11.47 100 855729 1475 109731995
Herpes zoster 122.53 11.47 1331 854498 107048 109626422
Upper gastrointestinal haemorrhage 121.24 11.47 125 855704 49971 109683499
X-ray abnormal 121.05 11.47 600 855229 37517 109695953
Palpitations 120.67 11.47 729 855100 158483 109574987
Device difficult to use 120.41 11.47 6 855823 18799 109714671
Lymphopenia 120.33 11.47 622 855207 39548 109693922
Pulmonary embolism 120.22 11.47 1070 854759 213404 109520066
Parkinsonism 120.15 11.47 15 855814 22172 109711298
Adenovirus infection 120.04 11.47 264 855565 10730 109722740
Blood creatinine increased 119.72 11.47 875 854954 182014 109551456
Procedural pain 119.37 11.47 63 855766 35502 109697968
Cardiomegaly 118.03 11.47 39 855790 29091 109704379
Jaundice 117.86 11.47 172 855657 59064 109674406
Chronic kidney disease 117.23 11.47 260 855569 76031 109657439
Hypercholesterolaemia 117.16 11.47 1146 854683 89691 109643779
Dysuria 116.81 11.47 178 855651 60053 109673417
Gamma-glutamyltransferase increased 116.22 11.47 184 855645 61125 109672345
Cardiogenic shock 115.54 11.47 165 855664 57173 109676297
Autoimmune disorder 115.28 11.47 885 854944 64598 109668872
Pneumonia 114.81 11.47 8065 847764 868649 108864821
Blood sodium decreased 114.40 11.47 78 855751 38241 109695229
Metastases to liver 113.96 11.47 66 855763 35320 109698150
Pulmonary hypertension 113.17 11.47 157 855672 55063 109678407
Retinitis 112.89 11.47 523 855306 31804 109701666
Schizophrenia 112.89 11.47 17 855812 21809 109711661
Tubulointerstitial nephritis 112.60 11.47 153 855676 54131 109679339
Urinary incontinence 112.28 11.47 126 855703 48461 109685009
Product storage error 112.20 11.47 17 855812 21711 109711759
Injection site urticaria 111.82 11.47 5 855824 17210 109716260
Cytomegalovirus viraemia 111.79 11.47 347 855482 17417 109716053
Temperature regulation disorder 111.74 11.47 282 855547 12544 109720926
Peripheral swelling 110.43 11.47 3992 851837 400042 109333428
Interstitial lung disease 110.25 11.47 1601 854228 137733 109595737
Onychomadesis 109.51 11.47 666 855163 44997 109688473
Heart rate decreased 108.17 11.47 1047 854782 81709 109651761
Skin discolouration 107.12 11.47 133 855696 48913 109684557
Troponin increased 107.09 11.47 48 855781 29718 109703752
Delusion 107.00 11.47 26 855803 23729 109709741
Stevens-Johnson syndrome 106.89 11.47 123 855706 46778 109686692
Mydriasis 106.38 11.47 21 855808 22136 109711334
Inappropriate schedule of product administration 106.36 11.47 1034 854795 202603 109530867
Weight increased 106.22 11.47 4111 851718 415533 109317937
Anaphylactic shock 106.20 11.47 146 855683 51400 109682070
Polyomavirus-associated nephropathy 105.97 11.47 211 855618 7990 109725480
Ascites 105.56 11.47 366 855463 92442 109641028
Device dislocation 105.17 11.47 57 855772 31647 109701823
Atrial fibrillation 104.94 11.47 1203 854626 228439 109505031
Demyelination 104.75 11.47 228 855601 9201 109724269
Needle issue 104.50 11.47 9 855820 17831 109715639
Hyperthyroidism 104.00 11.47 48 855781 29213 109704257
Activated partial thromboplastin time prolonged 103.69 11.47 23 855806 22345 109711125
Female genital tract fistula 103.49 11.47 6 855823 16513 109716957
Liver function test abnormal 103.49 11.47 238 855591 68712 109664758
Blood potassium increased 102.90 11.47 65 855764 33184 109700286
Faeces discoloured 102.83 11.47 68 855761 33880 109699590
Onychomycosis 102.13 11.47 577 855252 37954 109695516
Pollakiuria 101.71 11.47 115 855714 44080 109689390
Haemoglobin decreased 101.56 11.47 1335 854494 247392 109486078
Febrile bone marrow aplasia 101.55 11.47 332 855497 17133 109716337
Chromaturia 101.54 11.47 50 855779 29310 109704160
Haemorrhage 101.42 11.47 452 855377 106240 109627230
Leukopenia 101.40 11.47 1667 854162 147124 109586346
Hypersomnia 101.35 11.47 45 855784 28016 109705454
Blood lactate dehydrogenase increased 100.92 11.47 638 855191 43696 109689774
Immune effector cell-associated neurotoxicity syndrome 100.78 11.47 297 855532 14485 109718985
Septic shock 100.46 11.47 1746 854083 155782 109577688
Haematoma 100.31 11.47 187 855642 58289 109675181
Product dose omission in error 99.71 11.47 29 855800 23483 109709987
Prescribed underdose 99.65 11.47 853 854976 64321 109669149
Cardiac failure 99.55 11.47 949 854880 186677 109546793
Fear 99.48 11.47 28 855801 23165 109710305
Torsade de pointes 99.35 11.47 26 855803 22574 109710896
Blood pressure increased 99.00 11.47 2660 853169 255713 109477757
Treatment noncompliance 98.59 11.47 266 855563 72724 109660746
Apparent death 98.58 11.47 117 855712 2785 109730685
Glomerulonephritis 98.18 11.47 150 855679 4580 109728890
Cytomegalovirus chorioretinitis 97.69 11.47 188 855641 6940 109726530
Maternal exposure timing unspecified 97.65 11.47 371 855458 20642 109712828
Epstein-Barr virus infection reactivation 97.01 11.47 138 855691 3946 109729524
Intestinal obstruction 96.91 11.47 164 855665 53063 109680407
Arthritis 96.86 11.47 1829 854000 165757 109567713
Abortion spontaneous 96.84 11.47 74 855755 34208 109699262
Sinus tachycardia 96.81 11.47 121 855708 44372 109689098
Pneumocystis jirovecii infection 96.26 11.47 143 855686 4257 109729213
Salivary hypersecretion 96.26 11.47 11 855818 17410 109716060
Skin necrosis 96.03 11.47 375 855454 21137 109712333
Lupus vulgaris 95.56 11.47 516 855313 33367 109700103
SLE arthritis 94.88 11.47 60 855769 577 109732893
Pneumonia cytomegaloviral 94.80 11.47 183 855646 6771 109726699
Drug level decreased 94.67 11.47 15 855814 18533 109714937
Hypocalcaemia 94.62 11.47 230 855599 65136 109668334
Back injury 94.54 11.47 660 855169 46739 109686731
Blood immunoglobulin G decreased 93.93 11.47 158 855671 5242 109728228
Electrocardiogram abnormal 93.55 11.47 16 855813 18693 109714777
Presyncope 93.34 11.47 146 855683 48741 109684729
Prothrombin time prolonged 92.67 11.47 12 855817 17249 109716221
Smooth muscle cell neoplasm 91.94 11.47 81 855748 1336 109732134
C-reactive protein 90.39 11.47 469 855360 29862 109703608
Neutrophil count decreased 90.34 11.47 1376 854453 119565 109613905
Hyperhidrosis 90.00 11.47 970 854859 186328 109547142
Arteriosclerosis coronary artery 89.59 11.47 41 855788 25077 109708393
Mania 89.39 11.47 25 855804 20771 109712699
Oral pruritus 89.11 11.47 119 855710 3201 109730269
Hepatic function abnormal 88.72 11.47 372 855457 88923 109644547
Cellulitis 88.30 11.47 591 855238 125425 109608045
Rhinitis allergic 88.15 11.47 16 855813 17906 109715564
Rash 87.48 11.47 7432 848397 813532 108919938
Blood calcium increased 86.82 11.47 17 855812 18023 109715447
Gastritis 86.68 11.47 178 855651 53521 109679949
Organising pneumonia 86.66 11.47 275 855554 13968 109719502
Mitral valve incompetence 86.66 11.47 78 855751 33251 109700219
Device leakage 86.54 11.47 11 855818 16037 109717433
Drug dose omission by device 85.91 11.47 7 855822 14509 109718961
Inappropriate antidiuretic hormone secretion 85.91 11.47 81 855748 33770 109699700
Hypervolaemia 85.88 11.47 157 855672 49303 109684167
Neutropenic sepsis 85.88 11.47 467 855362 30279 109703191
SARS-CoV-2 antibody test negative 85.57 11.47 48 855781 362 109733108
Live birth 85.43 11.47 868 854961 68616 109664854
Abdominal distension 85.28 11.47 904 854925 174199 109559271
Red blood cell sedimentation rate abnormal 85.20 11.47 396 855433 24113 109709357
Pulmonary arterial hypertension 84.94 11.47 76 855753 32492 109700978
Acidosis 84.79 11.47 34 855795 22497 109710973
Joint stiffness 84.59 11.47 844 854985 66399 109667071
Shock 84.51 11.47 180 855649 53408 109680062
Dysarthria 84.47 11.47 349 855480 83772 109649698
Haematuria 84.21 11.47 343 855486 82662 109650808
Tinnitus 83.76 11.47 218 855611 60322 109673148
Elbow deformity 83.66 11.47 79 855750 1431 109732039
Transfusion 82.75 11.47 47 855782 25425 109708045
Macular degeneration 82.64 11.47 32 855797 21627 109711843
Eye pain 82.63 11.47 164 855665 49935 109683535
Blood immunoglobulin M decreased 82.41 11.47 90 855739 1951 109731519
Acquired gene mutation 82.17 11.47 104 855725 2650 109730820
Cystitis haemorrhagic 81.99 11.47 244 855585 11965 109721505
Haematocrit decreased 81.94 11.47 251 855578 65866 109667604
Musculoskeletal deformity 81.78 11.47 79 855750 1474 109731996
Cardiac disorder 81.34 11.47 309 855520 75971 109657499
Appendicitis 80.97 11.47 61 855768 28403 109705067
Pancytopenia 80.85 11.47 2160 853669 207453 109526017
Extra dose administered 80.76 11.47 3 855826 12156 109721314
Electrocardiogram QRS complex prolonged 80.76 11.47 5 855824 13016 109720454
Blood loss anaemia 80.66 11.47 20 855809 18005 109715465
Erectile dysfunction 80.34 11.47 22 855807 18534 109714936
Coagulopathy 80.21 11.47 120 855709 40791 109692679
Central nervous system lymphoma 80.01 11.47 108 855721 2936 109730534
Hospice care 79.80 11.47 4 855825 12469 109721001
Product prescribing error 79.64 11.47 174 855655 51157 109682313
Cerebral infarction 79.37 11.47 177 855652 51661 109681809
Blood glucose decreased 79.11 11.47 67 855762 29421 109704049
Dementia 78.97 11.47 77 855752 31596 109701874
Haemophagocytic lymphohistiocytosis 78.69 11.47 465 855364 31094 109702376
Burning sensation 78.67 11.47 273 855556 68939 109664531
Immunoglobulins decreased 78.66 11.47 95 855734 2304 109731166
Secondary immunodeficiency 77.62 11.47 134 855695 4542 109728928
Paranoia 77.53 11.47 38 855791 22336 109711134
Posterior reversible encephalopathy syndrome 77.51 11.47 488 855341 33373 109700097
Acute myeloid leukaemia 77.39 11.47 533 855296 37577 109695893
Aspartate aminotransferase increased 77.35 11.47 827 855002 159109 109574361
Blood immunoglobulin A decreased 76.97 11.47 91 855738 2157 109731313
Mental disorder 76.81 11.47 113 855716 38678 109694792
Injection site warmth 76.56 11.47 20 855809 17385 109716085
Anger 76.04 11.47 26 855803 18981 109714489
Angina unstable 75.96 11.47 17 855812 16415 109717055
Blepharospasm 75.18 11.47 701 855128 54150 109679320
Miosis 75.17 11.47 38 855791 21945 109711525
Iron deficiency anaemia 74.96 11.47 80 855749 31479 109701991
Panic attack 74.92 11.47 68 855761 28872 109704598
Liver function test increased 74.67 11.47 1029 854800 87519 109645951
Obliterative bronchiolitis 74.38 11.47 116 855713 3607 109729863
Liver disorder 74.31 11.47 1529 854300 140714 109592756
Nasal polyps 73.78 11.47 8 855821 13192 109720278
Myocardial ischaemia 73.60 11.47 59 855770 26625 109706845
Hypophosphataemia 73.50 11.47 89 855740 33093 109700377
Nasal congestion 73.42 11.47 452 855377 97830 109635640
Proctitis 73.41 11.47 20 855809 16907 109716563
Ageusia 73.35 11.47 30 855799 19615 109713855
Encephalitis enteroviral 73.27 11.47 38 855791 240 109733230
Skin irritation 73.23 11.47 18 855811 16301 109717169
Renal impairment 73.09 11.47 1022 854807 187423 109546047
Micturition urgency 72.96 11.47 29 855800 19291 109714179
Hypokinesia 72.75 11.47 39 855790 21787 109711683
Pyrexia 72.52 11.47 7975 847854 890290 108843180
Abdominal pain lower 72.47 11.47 110 855719 37173 109696297
Tricuspid valve incompetence 72.07 11.47 48 855781 23825 109709645
Thirst 72.04 11.47 39 855790 21668 109711802
Arteriosclerosis 71.84 11.47 52 855777 24715 109708755
Sleep disorder due to a general medical condition 71.83 11.47 188 855641 51924 109681546
Visual acuity reduced 71.58 11.47 86 855743 32087 109701383
Dry mouth 71.36 11.47 2040 853789 197908 109535562
Staphylococcal bacteraemia 71.34 11.47 287 855542 16401 109717069
Sudden death 71.05 11.47 51 855778 24344 109709126
Cholestasis 70.99 11.47 258 855571 64260 109669210
Caesarean section 70.92 11.47 11 855818 13806 109719664
Blood pressure decreased 70.87 11.47 560 855269 114531 109618939
Red blood cell sedimentation rate 70.82 11.47 137 855692 5077 109728393
Hypothermia 70.27 11.47 60 855769 26242 109707228
Road traffic accident 70.13 11.47 1195 854634 106203 109627267
Mood altered 70.08 11.47 39 855790 21336 109712134
Post procedural complication 69.78 11.47 62 855767 26596 109706874
Arrhythmia 69.64 11.47 289 855540 69286 109664184
Pericardial effusion 69.64 11.47 219 855610 56998 109676472
Right ventricular failure 69.59 11.47 59 855770 25895 109707575
Haemodialysis 69.58 11.47 25 855804 17694 109715776
Blood pressure diastolic increased 69.20 11.47 309 855520 18498 109714972
Lymphadenopathy 68.95 11.47 777 855052 63058 109670412
Prostatic specific antigen increased 68.88 11.47 8 855821 12503 109720967
Seronegative arthritis 68.26 11.47 241 855588 12936 109720534
Full blood count decreased 68.07 11.47 89 855740 32010 109701460
Autoimmune haemolytic anaemia 67.97 11.47 208 855621 10359 109723111
Adverse event 67.56 11.47 1201 854628 107608 109625862
Dermatitis contact 67.46 11.47 13 855816 13940 109719530
Vaginal discharge 67.43 11.47 27 855802 17881 109715589
Bradykinesia 67.34 11.47 4 855825 10784 109722686
Eosinophilia 66.88 11.47 227 855602 57709 109675761
Complication associated with device 66.71 11.47 36 855793 20037 109713433
Illness 66.66 11.47 368 855461 81803 109651667
Parosmia 66.51 11.47 11 855818 13169 109720301
Acute generalised exanthematous pustulosis 66.15 11.47 43 855786 21621 109711849
Hip fracture 66.14 11.47 106 855723 35045 109698425
Rash papular 65.72 11.47 70 855759 27569 109705901
Gastrosplenic fistula 65.49 11.47 29 855800 121 109733349
Bacteraemia 65.43 11.47 556 855273 41834 109691636
Sinus bradycardia 65.39 11.47 79 855750 29404 109704066
Drug tolerance 65.22 11.47 278 855551 16307 109717163
Pain of skin 65.01 11.47 37 855792 19992 109713478
Drug dependence 64.80 11.47 186 855643 49834 109683636
Food allergy 64.76 11.47 316 855513 19632 109713838
Blood triglycerides increased 64.63 11.47 54 855775 23872 109709598
Atlantoaxial instability 64.45 11.47 36 855793 269 109733201
Haemorrhagic stroke 64.28 11.47 14 855815 13775 109719695
Hypertension 64.26 11.47 4679 851150 505405 109228065
Sleep disorder 64.20 11.47 2002 853827 196642 109536828
Headache 64.09 11.47 5918 849911 876459 108857011
Strongyloidiasis 64.08 11.47 128 855701 4858 109728612
Haemorrhoids 63.94 11.47 111 855718 35561 109697909
Chills 63.80 11.47 1929 853900 188651 109544819
Ulcer 63.66 11.47 560 855269 42556 109690914
Joint destruction 63.60 11.47 208 855621 10735 109722735
Meningoencephalitis viral 63.40 11.47 44 855785 501 109732969
Frequent bowel movements 63.38 11.47 310 855519 71080 109662390
Injection site induration 63.37 11.47 7 855822 11376 109722094
Alanine aminotransferase increased 63.24 11.47 1020 854809 182753 109550717
Hyperbilirubinaemia 63.05 11.47 87 855742 30584 109702886
Pseudomonas infection 62.88 11.47 400 855429 27453 109706017
Coombs positive haemolytic anaemia 62.74 11.47 69 855760 1508 109731962
Dysphonia 62.72 11.47 338 855491 75591 109657879
Coma scale abnormal 62.60 11.47 3 855826 9723 109723747
Adverse reaction 62.54 11.47 418 855411 29176 109704294
Dysstasia 61.57 11.47 100 855729 32886 109700584
Cerebral toxoplasmosis 61.53 11.47 97 855732 3045 109730425
Eye pruritus 61.52 11.47 99 855730 32676 109700794
Encephalopathy 61.47 11.47 371 855458 80684 109652786
Cystitis viral 61.30 11.47 66 855763 1407 109732063
Cardiac murmur 61.25 11.47 60 855769 24568 109708902
Heparin-induced thrombocytopenia 61.19 11.47 8 855821 11416 109722054
Productive cough 61.10 11.47 577 855252 113728 109619742
Immunosuppression 61.04 11.47 286 855543 17473 109715997
Pallor 60.69 11.47 228 855601 56239 109677231
Contrast media allergy 60.67 11.47 101 855728 3322 109730148
Drug level below therapeutic 60.58 11.47 9 855820 11664 109721806
Therapeutic response unexpected 60.57 11.47 57 855772 23786 109709684
Poor quality sleep 60.42 11.47 77 855752 28000 109705470
Dizziness postural 60.18 11.47 19 855810 14590 109718880
Forced expiratory volume decreased 60.17 11.47 14 855815 13162 109720308
Laryngitis 60.13 11.47 546 855283 41865 109691605
Myasthenia gravis 60.04 11.47 47 855782 21464 109712006
Dialysis 59.83 11.47 39 855790 19580 109713890
Surgical failure 59.82 11.47 53 855776 881 109732589
Middle insomnia 59.53 11.47 43 855786 20459 109713011
Ocular hyperaemia 59.45 11.47 135 855694 39151 109694319
Rash macular 59.30 11.47 132 855697 38554 109694916
Hiatus hernia 59.10 11.47 76 855753 27530 109705940
Follicular lymphoma 58.93 11.47 48 855781 707 109732763
Urticaria 58.88 11.47 3025 852804 315832 109417638
Apathy 58.71 11.47 26 855803 16213 109717257
Enterococcal infection 58.68 11.47 312 855517 20054 109713416
Pancreatitis 58.57 11.47 453 855376 93080 109640390
Pelvic pain 58.47 11.47 25 855804 15917 109717553
Intestinal sepsis 58.46 11.47 54 855775 950 109732520
Eructation 58.41 11.47 18 855811 14039 109719431
Immunodeficiency common variable 58.39 11.47 45 855784 609 109732861
Psychomotor hyperactivity 58.26 11.47 43 855786 20234 109713236
Sickle cell anaemia with crisis 58.21 11.47 4 855825 9541 109723929
Weight decreased 57.97 11.47 2995 852834 465062 109268408
Nervousness 57.93 11.47 124 855705 36727 109696743
Insurance issue 57.89 11.47 7 855822 10605 109722865
Electric shock 57.69 11.47 71 855758 1757 109731713
Subarachnoid haemorrhage 57.38 11.47 88 855741 29614 109703856
Alcohol poisoning 57.37 11.47 3 855826 9017 109724453
Eye irritation 57.35 11.47 107 855722 33345 109700125
Blood albumin decreased 57.28 11.47 78 855751 27574 109705896
Nocturia 57.16 11.47 30 855799 16960 109716510
Platelet count abnormal 56.70 11.47 140 855689 6142 109727328
Metastases to lung 56.43 11.47 57 855772 23006 109710464
Anuria 56.38 11.47 63 855766 24278 109709192
Initial insomnia 56.31 11.47 7 855822 10382 109723088
Electrolyte imbalance 56.22 11.47 127 855702 36901 109696569
Complication of device insertion 56.02 11.47 3 855826 8835 109724635
Atrioventricular block first degree 55.98 11.47 20 855809 14205 109719265
Temperature intolerance 55.76 11.47 235 855594 13715 109719755
Product administration interrupted 55.71 11.47 10 855819 11282 109722188
Skin burning sensation 55.65 11.47 52 855777 21773 109711697
Respiratory acidosis 55.16 11.47 19 855810 13807 109719663
Pemphigoid 55.08 11.47 43 855786 19664 109713806
Hypomania 55.05 11.47 7 855822 10203 109723267
Leukocytosis 54.87 11.47 222 855607 53606 109679864
Bradypnoea 54.62 11.47 3 855826 8646 109724824
Tumour flare 54.59 11.47 64 855765 1503 109731967
Subdural haematoma 54.57 11.47 126 855703 36328 109697142
Lymphadenitis 54.51 11.47 127 855702 5366 109728104
Bundle branch block left 54.46 11.47 16 855813 12872 109720598
West Nile viral infection 54.46 11.47 59 855770 1267 109732203
Exostosis 54.07 11.47 569 855260 45387 109688083
Chronic sinusitis 53.76 11.47 69 855760 25015 109708455
Hepatic cytolysis 53.67 11.47 231 855598 54822 109678648
Paraesthesia oral 53.18 11.47 113 855716 33558 109699912
Mental impairment 53.09 11.47 58 855771 22581 109710889
Fine motor skill dysfunction 52.64 11.47 136 855693 6138 109727332
Hypovolaemia 52.54 11.47 54 855775 21620 109711850
Pleural effusion 52.33 11.47 1014 854815 176695 109556775
Hypertriglyceridaemia 52.20 11.47 30 855799 16124 109717346
Femur fracture 52.17 11.47 173 855656 44296 109689174
Depression 52.15 11.47 1968 853861 315367 109418103
Mineral metabolism disorder 52.04 11.47 35 855794 377 109733093
Hyperlactacidaemia 51.94 11.47 3 855826 8283 109725187
Gout 51.87 11.47 130 855699 36436 109697034
Ketoacidosis 51.84 11.47 8 855821 10079 109723391
Lupus-like syndrome 51.79 11.47 513 855316 40279 109693191
Infusion site reaction 51.71 11.47 272 855557 17410 109716060
Blood iron abnormal 51.69 11.47 61 855768 1443 109732027
General physical health deterioration 51.64 11.47 3890 851939 421405 109312065
Campylobacter infection 51.59 11.47 77 855752 2302 109731168
Intentional dose omission 51.01 11.47 48 855781 20032 109713438
Remission not achieved 50.89 11.47 38 855791 489 109732981
Hepatitis cholestatic 50.80 11.47 37 855792 17529 109715941
Hypercapnia 50.68 11.47 12 855817 11147 109722323
Skin fissures 50.66 11.47 69 855760 24389 109709081
Lipase increased 50.61 11.47 42 855787 18630 109714840
Sleep apnoea syndrome 50.51 11.47 153 855676 40294 109693176
Blood phosphorus increased 50.49 11.47 32 855797 16308 109717162
Rib fracture 50.33 11.47 117 855712 33653 109699817
Cyanosis 50.23 11.47 96 855733 29645 109703825
Pulseless electrical activity 50.17 11.47 34 855795 16723 109716747
Left ventricular hypertrophy 49.82 11.47 20 855809 13224 109720246
Vaginal haemorrhage 49.69 11.47 73 855756 25001 109708469
Drug level above therapeutic 49.68 11.47 14 855815 11574 109721896
Catatonia 49.67 11.47 13 855816 11287 109722183
Eye swelling 49.65 11.47 114 855715 32934 109700536
Aspiration 49.46 11.47 101 855728 30432 109703038
Respiratory tract infection 49.37 11.47 804 855025 70813 109662657
Concussion 49.35 11.47 14 855815 11524 109721946
Oesophagitis 49.10 11.47 92 855737 28623 109704847
Lupus nephritis 48.98 11.47 110 855719 4535 109728935
Urine output decreased 48.77 11.47 49 855780 19827 109713643
Systemic lupus erythematosus rash 48.69 11.47 69 855760 1966 109731504
Cerebral haematoma 48.69 11.47 8 855821 9624 109723846
Pain in jaw 48.51 11.47 217 855612 50960 109682510
Bone swelling 48.46 11.47 65 855764 1756 109731714
Anti-cyclic citrullinated peptide antibody 48.39 11.47 292 855537 19672 109713798
Carotid artery occlusion 48.23 11.47 8 855821 9557 109723913
Hypoaesthesia 48.22 11.47 2931 852898 311292 109422178
Colitis ischaemic 48.02 11.47 40 855789 17710 109715760
Duodenal ulcer 48.01 11.47 48 855781 19466 109714004
Carotid artery thrombosis 47.99 11.47 174 855655 9464 109724006
Concomitant disease aggravated 47.93 11.47 34 855795 16330 109717140
Thinking abnormal 47.68 11.47 29 855800 15111 109718359
Glycosylated haemoglobin increased 47.55 11.47 68 855761 23551 109709919
Eosinophilic granulomatosis with polyangiitis 47.54 11.47 12 855817 10674 109722796
Status epilepticus 47.35 11.47 109 855720 31462 109702008
Chronic lymphocytic leukaemia transformation 47.18 11.47 29 855800 264 109733206
Spinal instability 47.16 11.47 35 855794 446 109733024
Cataract 47.11 11.47 871 854958 78614 109654856
Major depression 47.11 11.47 12 855817 10609 109722861
Bradyphrenia 46.99 11.47 16 855813 11712 109721758
Product preparation error 46.91 11.47 13 855816 10866 109722604
Tension headache 46.42 11.47 9 855820 9609 109723861
Fracture 46.40 11.47 75 855754 24713 109708757
Erythema 46.23 11.47 1815 854014 289632 109443838
Neurologic neglect syndrome 45.57 11.47 167 855662 9131 109724339
Hyperreflexia 45.52 11.47 9 855820 9476 109723994
Acute respiratory failure 45.50 11.47 368 855461 74892 109658578
Ischaemic stroke 45.40 11.47 165 855664 41098 109692372
Tearfulness 45.39 11.47 3 855826 7392 109726078
Varicella zoster virus infection 45.39 11.47 130 855699 6238 109727232
Euphoric mood 45.37 11.47 7 855822 8820 109724650
Loss of personal independence in daily activities 45.35 11.47 1500 854329 148520 109584950
Muscle twitching 45.18 11.47 103 855726 29832 109703638
Central nervous system lupus 45.05 11.47 54 855775 1299 109732171
Eosinophil count increased 45.05 11.47 58 855771 21000 109712470
Mantle cell lymphoma refractory 45.03 11.47 22 855807 120 109733350
Disability 44.86 11.47 393 855436 29830 109703640
Sputum discoloured 44.79 11.47 93 855736 27852 109705618
Malignant neoplasm progression 44.67 11.47 1019 854810 173548 109559922
Metastases to central nervous system 44.66 11.47 67 855762 22750 109710720
Tenosynovitis 44.58 11.47 246 855583 16037 109717433
5q minus syndrome 44.56 11.47 28 855801 266 109733204
Cytomegalovirus colitis 44.49 11.47 138 855691 6923 109726547
Skin ulcer 44.43 11.47 716 855113 62929 109670541
Face oedema 44.43 11.47 123 855706 33346 109700124
Bipolar disorder 44.39 11.47 8 855821 8999 109724471
Skin disorder 44.36 11.47 176 855653 42737 109690733
Osteoporosis 44.25 11.47 933 854896 86219 109647251
Pulse absent 44.23 11.47 16 855813 11276 109722194
Erythema multiforme 44.22 11.47 59 855770 21038 109712432
Mixed liver injury 44.21 11.47 19 855810 12060 109721410
Aortic stenosis 44.02 11.47 23 855806 13036 109720434
Epstein-Barr viraemia 43.76 11.47 90 855739 3489 109729981
Faeces soft 43.71 11.47 16 855813 11194 109722276
Brain natriuretic peptide increased 43.70 11.47 16 855813 11193 109722277
Pain in extremity 43.64 11.47 3212 852617 483906 109249564
International normalised ratio decreased 43.56 11.47 6 855823 8230 109725240
Gait disturbance 43.38 11.47 1736 854093 276472 109456998
Thrombosis 43.31 11.47 586 855243 108076 109625394
Therapy change 43.00 11.47 12 855817 9985 109723485
Enterovirus infection 42.90 11.47 77 855752 2693 109730777
Muscle spasms 42.87 11.47 1738 854091 276419 109457051
Metabolic encephalopathy 42.76 11.47 16 855813 11044 109722426
Radiculopathy 42.68 11.47 52 855777 19284 109714186
Gestational diabetes 42.54 11.47 4 855825 7385 109726085
Cardiovascular disorder 42.48 11.47 69 855760 22691 109710779
Benign prostatic hyperplasia 42.44 11.47 47 855782 18187 109715283
Product complaint 42.30 11.47 28 855801 13944 109719526
Large intestine polyp 42.23 11.47 33 855796 15084 109718386
Choking 42.19 11.47 33 855796 15077 109718393
Chest pain 42.18 11.47 2432 853397 373943 109359527
Gastritis erosive 42.16 11.47 20 855809 11980 109721490
Catarrh 42.16 11.47 4 855825 7331 109726139
Diabetes mellitus inadequate control 42.13 11.47 106 855723 29669 109703801
Head discomfort 42.04 11.47 51 855778 18949 109714521
Polyarthritis 41.99 11.47 271 855558 18692 109714778
Breast cancer metastatic 41.87 11.47 17 855812 11164 109722306
Eyelid oedema 41.78 11.47 34 855795 15228 109718242
Cholecystitis chronic 41.63 11.47 11 855818 9489 109723981
Adenovirus reactivation 41.55 11.47 39 855790 701 109732769
Adenoviral hepatitis 41.51 11.47 45 855784 967 109732503
Hypernatraemia 41.47 11.47 46 855783 17787 109715683
Groin pain 41.45 11.47 35 855794 15393 109718077
Musculoskeletal disorder 41.39 11.47 309 855520 22355 109711115
Eosinophilic pneumonia 41.38 11.47 4 855825 7223 109726247
Ammonia increased 41.37 11.47 7 855822 8243 109725227
Oliguria 41.37 11.47 50 855779 18607 109714863
Bronchitis chronic 41.36 11.47 107 855722 4833 109728637
Diplopia 41.32 11.47 175 855654 41719 109691751
Episcleritis 41.29 11.47 50 855779 1216 109732254
Lymphocytosis 41.05 11.47 113 855716 5298 109728172
Microsporidia infection 40.82 11.47 53 855776 1386 109732084
Chronic lymphocytic leukaemia refractory 40.80 11.47 20 855809 110 109733360
Chronic lymphocytic leukaemia 40.77 11.47 120 855709 5848 109727622
Colitis ulcerative 40.71 11.47 392 855437 76971 109656499
Proctalgia 40.71 11.47 26 855803 13196 109720274
Diabetes mellitus 40.68 11.47 533 855296 98848 109634622
Affective disorder 40.64 11.47 18 855811 11223 109722247
Anosmia 40.53 11.47 23 855806 12449 109721021
Breast cancer female 40.51 11.47 23 855806 12445 109721025
Deformity 40.49 11.47 171 855658 9989 109723481
Gene mutation 40.49 11.47 85 855744 3344 109730126
Immune-mediated hepatitis 40.38 11.47 3 855826 6708 109726762
Pneumonia adenoviral 40.36 11.47 36 855793 604 109732866
Toxic encephalopathy 40.28 11.47 35 855794 15179 109718291
Cytomegalovirus test positive 40.23 11.47 133 855696 6903 109726567
Plasma cell myeloma recurrent 40.05 11.47 4 855825 7038 109726432
Anticipatory anxiety 39.99 11.47 49 855780 1207 109732263
Incoherent 39.96 11.47 8 855821 8350 109725120
JC polyomavirus test positive 39.93 11.47 68 855761 2279 109731191
Rales 39.93 11.47 82 855747 24657 109708813
Atrioventricular block 39.84 11.47 43 855786 16834 109716636
Polydipsia 39.73 11.47 6 855823 7682 109725788
Red blood cell count decreased 39.55 11.47 323 855506 65600 109667870
Small intestinal obstruction 39.41 11.47 123 855706 32090 109701380
Laryngeal disorder 39.36 11.47 47 855782 1126 109732344
Colorectal cancer 39.09 11.47 11 855818 9103 109724367
Epstein-Barr virus associated lymphoma 39.04 11.47 56 855773 1614 109731856
Pruritus genital 39.01 11.47 3 855826 6519 109726951
Endophthalmitis 38.81 11.47 8 855821 8179 109725291
Device failure 38.72 11.47 5 855824 7202 109726268
Cardiac failure acute 38.70 11.47 80 855749 23998 109709472
Facial pain 38.58 11.47 37 855792 15302 109718168
Mesenteritis 38.51 11.47 28 855801 345 109733125
Ataxia 38.24 11.47 113 855716 29995 109703475
Steroid diabetes 38.17 11.47 108 855721 5146 109728324
Long QT syndrome 38.09 11.47 5 855824 7113 109726357
Central nervous system enteroviral infection 37.93 11.47 18 855811 91 109733379
B-cell lymphoma refractory 37.81 11.47 21 855808 155 109733315
Device occlusion 37.76 11.47 37 855792 15148 109718322
Faecal calprotectin increased 37.74 11.47 4 855825 6715 109726755
Influenza like illness 37.74 11.47 470 855359 87942 109645528
Extrasystoles 37.67 11.47 9 855820 8309 109725161
Personality change 37.65 11.47 19 855810 10983 109722487
Wrist deformity 37.60 11.47 79 855750 3110 109730360
Ventricular hypertrophy 37.58 11.47 5 855824 7040 109726430
Electrocardiogram ST segment elevation 37.58 11.47 12 855817 9148 109724322
Wrong product administered 37.40 11.47 19 855810 10941 109722529
Muscle strain 37.36 11.47 20 855809 11182 109722288
Hypoxic-ischaemic encephalopathy 37.35 11.47 11 855818 8836 109724634
Lacrimation increased 37.28 11.47 119 855710 30831 109702639
B-cell aplasia 37.14 11.47 28 855801 366 109733104
Renal transplant failure 37.12 11.47 71 855758 2609 109730861
Deep vein thrombosis 36.80 11.47 813 855016 139074 109594396
Klebsiella infection 36.66 11.47 273 855556 19736 109713734
Clonus 36.51 11.47 11 855818 8705 109724765
Carotid artery stenosis 36.49 11.47 13 855816 9250 109724220
Dermatitis acneiform 36.37 11.47 27 855802 12668 109720802
Rash maculo-papular 36.19 11.47 383 855446 73839 109659631
Psychomotor retardation 36.14 11.47 8 855821 7784 109725686
Heavy menstrual bleeding 36.13 11.47 44 855785 16321 109717149
Taste disorder 35.84 11.47 708 855121 64679 109668791
Norovirus infection 35.80 11.47 65 855764 2294 109731176
Renal injury 35.61 11.47 56 855773 18657 109714813
Blood immunoglobulin M increased 35.52 11.47 53 855776 1584 109731886
Human herpesvirus 6 infection 35.51 11.47 122 855707 6459 109727011
Visual impairment 35.44 11.47 781 855048 133647 109599823
Herpes simplex encephalitis 35.41 11.47 38 855791 807 109732663
Cholestatic liver injury 35.39 11.47 7 855822 7369 109726101
Apnoea 35.36 11.47 32 855797 13607 109719863
Hypoacusis 35.33 11.47 146 855683 35045 109698425
Spinal column injury 35.09 11.47 64 855765 2267 109731203
Asthma-chronic obstructive pulmonary disease overlap syndrome 35.07 11.47 4 855825 6340 109727130
Hypercalcaemia 34.89 11.47 531 855298 46126 109687344
Encephalitis viral 34.88 11.47 74 855755 2933 109730537
Arthritis bacterial 34.84 11.47 171 855658 10649 109722821
Cytomegalovirus enterocolitis 34.81 11.47 63 855766 2218 109731252
Libido decreased 34.75 11.47 3 855826 5932 109727538
Bladder cancer 34.71 11.47 65 855764 20227 109713243
Enterococcal bacteraemia 34.68 11.47 94 855735 4367 109729103
Mean platelet volume decreased 34.63 11.47 78 855751 3222 109730248
Normochromic normocytic anaemia 34.62 11.47 30 855799 13027 109720443
Ankle arthroplasty 34.61 11.47 67 855762 2484 109730986
Thyroid neoplasm 34.61 11.47 78 855751 3223 109730247
Coronary arterial stent insertion 34.60 11.47 3 855826 5912 109727558
Cerebral aspergillosis 34.39 11.47 63 855766 2239 109731231
Blood thyroid stimulating hormone increased 34.18 11.47 27 855802 12274 109721196
Exercise tolerance decreased 34.14 11.47 26 855803 12041 109721429
Dyspnoea at rest 34.12 11.47 11 855818 8335 109725135
Ventricular extrasystoles 34.09 11.47 78 855751 22563 109710907
Blood immunoglobulin E increased 34.07 11.47 8 855821 7474 109725996
Arterial occlusive disease 34.04 11.47 219 855610 15089 109718381
Mucosal inflammation 34.03 11.47 980 854849 95161 109638309
Acute hepatitis B 34.00 11.47 31 855798 536 109732934
Chest discomfort 33.92 11.47 1055 854774 172793 109560677
Pseudomonal bacteraemia 33.88 11.47 92 855737 4279 109729191
Mite allergy 33.79 11.47 3 855826 5800 109727670
Stupor 33.60 11.47 11 855818 8254 109725216
Paraesthesia ear 33.55 11.47 30 855799 505 109732965
Neuritis 33.52 11.47 8 855821 7391 109726079
Overweight 33.51 11.47 5 855824 6459 109727011
Muscle tightness 33.33 11.47 39 855790 14723 109718747
High density lipoprotein decreased 33.29 11.47 3 855826 5730 109727740
Monocyte count increased 33.22 11.47 196 855633 13097 109720373
Blood pressure inadequately controlled 33.14 11.47 9 855820 7624 109725846
CD4 lymphocytes decreased 33.13 11.47 72 855757 2902 109730568
Marginal zone lymphoma recurrent 33.08 11.47 13 855816 37 109733433
Emotional disorder 33.06 11.47 46 855783 16114 109717356
Rheumatoid factor increased 33.03 11.47 65 855764 2440 109731030
Diverticulum 32.97 11.47 43 855786 15483 109717987
Peripheral coldness 32.95 11.47 58 855771 18482 109714988
Amylase increased 32.91 11.47 29 855800 12490 109720980
Polyuria 32.89 11.47 54 855775 17684 109715786
Impaired driving ability 32.86 11.47 5 855824 6365 109727105
Mantle cell lymphoma 32.81 11.47 52 855777 1640 109731830
Hypertonia 32.77 11.47 12 855817 8394 109725076
International normalised ratio abnormal 32.77 11.47 5 855824 6352 109727118
Crying 32.68 11.47 96 855733 25532 109707938
Vascular access complication 32.61 11.47 65 855764 2463 109731007
Petit mal epilepsy 32.58 11.47 9 855820 7538 109725932
Tongue pruritus 32.50 11.47 37 855792 841 109732629
Incontinence 32.41 11.47 49 855780 16586 109716884
Supraventricular tachycardia 32.23 11.47 90 855739 24332 109709138
Therapeutic product effect incomplete 32.17 11.47 2076 853753 221729 109511741
Neutropenic infection 32.17 11.47 75 855754 3170 109730300
Coronary artery occlusion 32.16 11.47 45 855784 15727 109717743
Fatigue 32.15 11.47 8647 847182 1207311 108526159
Respiratory symptom 32.14 11.47 41 855788 14904 109718566
Hyperprolactinaemia 32.06 11.47 6 855823 6569 109726901
Femoral neck fracture 31.97 11.47 30 855799 12537 109720933
Musculoskeletal chest pain 31.97 11.47 115 855714 28732 109704738
Faecaloma 31.96 11.47 41 855788 14867 109718603
Prostate cancer 31.96 11.47 166 855663 37475 109695995
Self-medication 31.90 11.47 5 855824 6227 109727243
Mucous stools 31.82 11.47 7 855822 6840 109726630
Herpes simplex 31.72 11.47 220 855609 15544 109717926
Cardiac failure chronic 31.71 11.47 36 855793 13775 109719695
Mood swings 31.66 11.47 82 855747 22730 109710740
Asphyxia 31.62 11.47 38 855791 14177 109719293
Hepatic cancer 31.61 11.47 24 855805 11132 109722338
Conjunctivitis 31.60 11.47 144 855685 33648 109699822
Hypopnoea 31.59 11.47 25 855804 11355 109722115
Nephrogenic systemic fibrosis 31.49 11.47 3 855826 5480 109727990
Perineal rash 31.43 11.47 15 855814 77 109733393
Blood lactic acid increased 31.41 11.47 46 855783 15775 109717695
Movement disorder 31.21 11.47 160 855669 36244 109697226
Malignant transformation 31.14 11.47 48 855781 1477 109731993
Dermatitis bullous 31.01 11.47 55 855774 17474 109715996
Drug abuser 30.95 11.47 3 855826 5406 109728064
Dry eye 30.95 11.47 279 855550 55514 109677956
Vitreous floaters 30.92 11.47 16 855813 9118 109724352
Ventricular arrhythmia 30.83 11.47 20 855809 10067 109723403
Hepatic steatosis 30.80 11.47 236 855593 48595 109684875
Walking aid user 30.70 11.47 313 855516 24762 109708708
Social avoidant behaviour 30.67 11.47 3 855826 5366 109728104
Expired product administered 30.59 11.47 13 855816 8307 109725163
Spinal operation 30.59 11.47 24 855805 10948 109722522
Atelectasis 30.55 11.47 163 855666 36549 109696921
Metastases to lymph nodes 30.54 11.47 43 855786 14989 109718481
Diarrhoea haemorrhagic 30.53 11.47 46 855783 15593 109717877
Terminal state 30.53 11.47 105 855724 5562 109727908
Catheter site erythema 30.48 11.47 5 855824 6023 109727447
Seasonal allergy 30.47 11.47 67 855762 19655 109713815
Abnormal loss of weight 30.46 11.47 21 855808 10236 109723234
Hepatic encephalopathy 30.42 11.47 114 855715 28142 109705328
Gastrointestinal sounds abnormal 30.42 11.47 5 855824 6013 109727457
Porphyria acute 30.41 11.47 249 855580 18531 109714939
Bunion operation 30.39 11.47 37 855792 905 109732565
Joint dislocation 30.33 11.47 401 855428 33789 109699681
Toxic skin eruption 30.29 11.47 110 855719 27405 109706065
Increased appetite 30.27 11.47 43 855786 14934 109718536
Cardiac operation 30.26 11.47 5 855824 5990 109727480
Ankle operation 30.26 11.47 45 855784 1341 109732129
Adjustment disorder 30.17 11.47 164 855665 10631 109722839
Hiccups 30.14 11.47 33 855796 12836 109720634
Condition aggravated 30.13 11.47 6280 849549 728556 109004914
Non-cardiac chest pain 30.12 11.47 21 855808 10177 109723293
Skin lesion 30.05 11.47 255 855574 51376 109682094
Flank pain 29.96 11.47 86 855743 23044 109710426
Shock haemorrhagic 29.94 11.47 109 855720 27138 109706332
Drooling 29.92 11.47 9 855820 7130 109726340
Polyomavirus viraemia 29.86 11.47 76 855753 3398 109730072
Atrial tachycardia 29.72 11.47 17 855812 9161 109724309
Intercepted product preparation error 29.69 11.47 8 855821 6812 109726658
Hepatic cirrhosis 29.63 11.47 709 855120 66917 109666553
Thrombocytopenia 29.63 11.47 3109 852720 345776 109387694
Renal tubular necrosis 29.62 11.47 128 855701 30347 109703123
Autoimmune lymphoproliferative syndrome 29.62 11.47 20 855809 217 109733253
Infusion site pain 29.61 11.47 56 855773 17363 109716107
Secretion discharge 29.48 11.47 71 855758 20173 109713297
Jaundice cholestatic 29.47 11.47 42 855787 14566 109718904
Device breakage 29.38 11.47 38 855791 13731 109719739
Paradoxical drug reaction 29.28 11.47 20 855809 9797 109723673
Skin abrasion 29.18 11.47 50 855779 16101 109717369
Neuroborreliosis 29.18 11.47 18 855811 165 109733305
Pancreatitis necrotising 29.11 11.47 4 855825 5497 109727973
Hepatocellular injury 29.08 11.47 251 855578 50391 109683079
Prescription drug used without a prescription 29.08 11.47 4 855825 5492 109727978
Human polyomavirus infection 29.08 11.47 51 855778 1751 109731719
Joint arthroplasty 28.99 11.47 76 855753 3461 109730009
Transaminases increased 28.96 11.47 332 855497 63058 109670412
Anal incontinence 28.94 11.47 81 855748 21883 109711587
Colitis 28.86 11.47 588 855241 101735 109631735
Pneumonia viral 28.86 11.47 166 855663 10991 109722479
Viral haemorrhagic cystitis 28.85 11.47 74 855755 3325 109730145
Gangrene 28.84 11.47 221 855608 16120 109717350
Abnormal faeces 28.66 11.47 18 855811 9218 109724252
Bone pain 28.65 11.47 344 855485 64789 109668681
Lumbosacral plexopathy 28.63 11.47 15 855814 97 109733373
Glomerulonephritis rapidly progressive 28.63 11.47 57 855772 2158 109731312
Sputum increased 28.58 11.47 5 855824 5746 109727724
Coronary artery bypass 28.44 11.47 6 855823 6036 109727434
Acne 28.36 11.47 148 855681 33372 109700098
Bundle branch block right 28.26 11.47 32 855797 12259 109721211
Arthrodesis 28.25 11.47 64 855765 2654 109730816
Blood glucose abnormal 28.23 11.47 35 855794 12881 109720589
Potentiating drug interaction 28.23 11.47 29 855800 11614 109721856
Escherichia bacteraemia 28.13 11.47 154 855675 10010 109723460
Oxygen consumption increased 28.12 11.47 5 855824 5680 109727790
Breast cancer stage II 28.12 11.47 330 855499 27045 109706425
Renal disorder 28.07 11.47 246 855583 49233 109684237
Pneumonia bacterial 28.06 11.47 319 855510 25942 109707528
Paraneoplastic pemphigus 28.05 11.47 18 855811 178 109733292
Atrioventricular block complete 28.02 11.47 72 855757 20010 109713460
Blood chloride decreased 27.96 11.47 18 855811 9097 109724373
Sensory disturbance 27.94 11.47 58 855771 17371 109716099
Gingival swelling 27.92 11.47 4 855825 5326 109728144
Glomerular filtration rate decreased 27.91 11.47 122 855707 28834 109704636
Nystagmus 27.88 11.47 29 855800 11548 109721922
Peptic ulcer 27.86 11.47 12 855817 7607 109725863
Device use error 27.81 11.47 18 855811 9071 109724399
Photophobia 27.73 11.47 104 855725 25667 109707803
Breast pain 27.72 11.47 22 855807 9978 109723492
Essential hypertension 27.69 11.47 13 855816 7834 109725636
Haemarthrosis 27.68 11.47 11 855818 7318 109726152
Retroperitoneal lymphadenopathy 27.66 11.47 44 855785 1392 109732078
Atypical femur fracture 27.63 11.47 7 855822 6212 109727258
Bronchospasm 27.60 11.47 130 855699 30109 109703361
Bradyarrhythmia 27.55 11.47 3 855826 4931 109728539
Sluggishness 27.54 11.47 12 855817 7555 109725915
Pruritus allergic 27.53 11.47 48 855781 1640 109731830
Pneumonia klebsiella 27.51 11.47 113 855716 6519 109726951
Nephrolithiasis 27.50 11.47 354 855475 65858 109667612
Injection site irritation 27.48 11.47 3 855826 4921 109728549
Gastric disorder 27.45 11.47 386 855443 32971 109700499
Gynaecomastia 27.43 11.47 20 855809 9470 109724000
Herpes oesophagitis 27.28 11.47 24 855805 395 109733075
Cell-mediated immune deficiency 27.25 11.47 19 855810 218 109733252
Orthopnoea 27.24 11.47 27 855802 10994 109722476
Embolic stroke 27.18 11.47 17 855812 8726 109724744
Gastrointestinal pain 27.14 11.47 31 855798 11829 109721641
Scoliosis 27.12 11.47 17 855812 8716 109724754
Leukoerythroblastosis 27.07 11.47 22 855807 323 109733147
Anal fissure 27.06 11.47 22 855807 9859 109723611
Neutrophilia 27.06 11.47 24 855805 10305 109723165
Hyperpyrexia 27.04 11.47 129 855700 7940 109725530
Cytology abnormal 27.01 11.47 22 855807 324 109733146
Spinal pain 26.91 11.47 65 855764 18450 109715020
Pancreatic carcinoma 26.91 11.47 46 855783 14826 109718644
Occult blood positive 26.79 11.47 12 855817 7433 109726037
Epstein-Barr virus associated lymphoproliferative disorder 26.77 11.47 90 855739 4712 109728758
Atrioventricular block second degree 26.71 11.47 15 855814 8166 109725304
Premature delivery 26.62 11.47 134 855695 30498 109702972
Procedural complication 26.61 11.47 16 855813 8389 109725081
Clostridium test positive 26.56 11.47 27 855802 10866 109722604
Product dispensing error 26.53 11.47 54 855775 16291 109717179
Low density lipoprotein increased 26.51 11.47 26 855803 10640 109722830
Intraocular pressure increased 26.47 11.47 27 855802 10849 109722621
Venoocclusive liver disease 26.47 11.47 205 855624 15002 109718468
Human herpesvirus 8 infection 26.45 11.47 50 855779 1821 109731649
Hepatitis C RNA increased 26.32 11.47 24 855805 415 109733055
Lichenoid keratosis 26.31 11.47 8 855821 6294 109727176
Cardiac pacemaker insertion 26.30 11.47 8 855821 6293 109727177
Primary mediastinal large B-cell lymphoma recurrent 26.22 11.47 15 855814 118 109733352
Nodule 26.21 11.47 376 855453 32255 109701215
Lip oedema 26.19 11.47 13 855816 7587 109725883
Refusal of treatment by patient 26.17 11.47 21 855808 9473 109723997
Contusion 26.07 11.47 2121 853708 231240 109502230
Oral pain 26.02 11.47 176 855653 37268 109696202
Hepatitis B surface antigen positive 26 11.47 17 855812 174 109733296
Amenorrhoea 25.98 11.47 20 855809 9211 109724259
Iron deficiency 25.96 11.47 66 855763 18410 109715060
Ovarian hyperstimulation syndrome 25.90 11.47 5 855824 5355 109728115
Red cell distribution width decreased 25.82 11.47 55 855774 2186 109731284
Carpal tunnel syndrome 25.81 11.47 89 855740 22521 109710949
Gastrointestinal motility disorder 25.76 11.47 12 855817 7264 109726206
Craniocerebral injury 25.76 11.47 7 855822 5927 109727543
Bing-Neel syndrome 25.75 11.47 9 855820 16 109733454
Ischaemic cardiomyopathy 25.71 11.47 15 855814 7996 109725474
Dyslipidaemia 25.70 11.47 53 855776 15912 109717558
Autoimmune hepatitis 25.69 11.47 47 855782 14757 109718713
Premature labour 25.65 11.47 20 855809 9152 109724318
Bacterial sepsis 25.59 11.47 153 855676 10273 109723197
Coxsackie viral infection 25.55 11.47 12 855817 59 109733411
Systemic candida 25.54 11.47 148 855681 9826 109723644
Poor quality product administered 25.47 11.47 3 855826 4638 109728832
Coronary artery stenosis 25.41 11.47 42 855787 13716 109719754
Post procedural haemorrhage 25.39 11.47 51 855778 15461 109718009
Candida infection 25.37 11.47 517 855312 47492 109685978
Therapeutic reaction time decreased 25.35 11.47 5 855824 5274 109728196
Complication of device removal 25.32 11.47 3 855826 4617 109728853
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 25.31 11.47 10 855819 29 109733441
Blood glucose fluctuation 25.30 11.47 14 855815 7684 109725786
Inhibitory drug interaction 25.25 11.47 4 855825 4943 109728527
Muscle disorder 25.22 11.47 10 855819 6662 109726808
Renal tubular disorder 25.17 11.47 13 855816 7416 109726054
N-terminal prohormone brain natriuretic peptide increased 25.14 11.47 8 855821 6113 109727357
Parvovirus B19 infection reactivation 25.06 11.47 10 855819 30 109733440
Confusional state 25.05 11.47 3210 852619 465470 109268000
Pharyngitis streptococcal 25.01 11.47 40 855789 13237 109720233
Graft versus host disease in gastrointestinal tract 24.90 11.47 136 855693 8832 109724638
Skin laceration 24.80 11.47 156 855673 33597 109699873
Screaming 24.79 11.47 4 855825 4877 109728593
Spirometry abnormal 24.79 11.47 6 855823 5491 109727979
Pregnancy 24.73 11.47 543 855286 50524 109682946
Radiation pneumonitis 24.73 11.47 3 855826 4533 109728937
Psychiatric symptom 24.63 11.47 21 855808 9192 109724278
Behaviour disorder 24.58 11.47 23 855806 9624 109723846
Tachypnoea 24.56 11.47 191 855638 39204 109694266
Cushingoid 24.49 11.47 165 855664 11547 109721923
Fistula 24.45 11.47 51 855778 15248 109718222
Psychomotor skills impaired 24.44 11.47 12 855817 7046 109726424
Swollen joint count 24.39 11.47 132 855697 8542 109724928
Blood creatine increased 24.37 11.47 32 855797 11489 109721981
Oesophageal pain 24.31 11.47 5 855824 5120 109728350
Transplant rejection 24.29 11.47 294 855535 24273 109709197
Cancer pain 24.24 11.47 11 855818 6761 109726709
Bronchitis 24.22 11.47 981 854848 156051 109577419
Hepatitis acute 24.14 11.47 70 855759 18696 109714774
Diabetic neuropathy 24.08 11.47 12 855817 6987 109726483
Blood thyroid stimulating hormone decreased 24.03 11.47 13 855816 7226 109726244
Arteriospasm coronary 24.02 11.47 21 855808 9079 109724391
Abdominal tenderness 23.97 11.47 37 855792 12420 109721050
Gastric stenosis 23.96 11.47 17 855812 201 109733269
Renal cyst 23.96 11.47 67 855762 18105 109715365
Hairy cell leukaemia recurrent 23.95 11.47 7 855822 4 109733466
Device adhesion issue 23.95 11.47 22 855807 9288 109724182
Neuropathy peripheral 23.93 11.47 1138 854691 178139 109555331
Tumour marker increased 23.87 11.47 5 855824 5055 109728415
Anti-neutrophil cytoplasmic antibody positive vasculitis 23.83 11.47 94 855735 5323 109728147
Renal vein thrombosis 23.81 11.47 36 855793 1089 109732381
Electroencephalogram abnormal 23.75 11.47 9 855820 6164 109727306
Meningitis cryptococcal 23.73 11.47 86 855743 4676 109728794
Communication disorder 23.73 11.47 5 855824 5034 109728436
Refractory anaemia with an excess of blasts 23.72 11.47 31 855798 816 109732654
Diastolic dysfunction 23.72 11.47 37 855792 12367 109721103
Blood phosphorus decreased 23.70 11.47 15 855814 7650 109725820
Post cholecystectomy syndrome 23.58 11.47 31 855798 821 109732649
Injection site discomfort 23.53 11.47 12 855817 6895 109726575
Immune-mediated lung disease 23.50 11.47 6 855823 5297 109728173
Malnutrition 23.33 11.47 120 855709 27159 109706311
Dysplasia 23.22 11.47 47 855782 1801 109731669
Cholecystitis 23.20 11.47 112 855717 25770 109707700
Logorrhoea 23.17 11.47 5 855824 4952 109728518
Chronic allograft nephropathy 23.15 11.47 51 855778 2075 109731395
Respiration abnormal 23.15 11.47 25 855804 9784 109723686
Laryngeal stenosis 23.12 11.47 40 855789 1358 109732112
Feeding disorder 23.12 11.47 86 855743 21276 109712194
Meningitis herpes 23.10 11.47 19 855810 284 109733186
Gastric polyps 23.08 11.47 7 855822 5516 109727954
Restless legs syndrome 22.99 11.47 105 855724 24521 109708949
Hepatitis 22.91 11.47 883 854946 89171 109644299
Injection site discolouration 22.84 11.47 22 855807 9081 109724389
Lymphoedema 22.83 11.47 51 855778 14878 109718592
Lymphoplasmacytoid lymphoma/immunocytoma 22.81 11.47 11 855818 58 109733412
Traumatic lung injury 22.80 11.47 57 855772 2520 109730950
Anovulatory cycle 22.73 11.47 14 855815 128 109733342
Aortic valve incompetence 22.72 11.47 31 855798 10950 109722520
Dust allergy 22.67 11.47 9 855820 5992 109727478
Troponin I increased 22.62 11.47 7 855822 5445 109728025
Granulocyte count decreased 22.62 11.47 75 855754 3899 109729571
Nasal dryness 22.49 11.47 8 855821 5698 109727772
Peripheral vascular disorder 22.38 11.47 20 855809 8556 109724914
Splenic marginal zone lymphoma 22.37 11.47 12 855817 82 109733388
Lipodystrophy acquired 22.33 11.47 4 855825 4520 109728950
Acute myelomonocytic leukaemia 22.33 11.47 22 855807 421 109733049
Soft tissue disorder 22.32 11.47 69 855760 3455 109730015
Hysterectomy 22.30 11.47 18 855811 8096 109725374
Rhonchi 22.29 11.47 4 855825 4514 109728956
Chronic graft versus host disease in skin 22.21 11.47 57 855772 2562 109730908
Brain oedema 22.20 11.47 145 855684 30953 109702517
Glucose tolerance impaired 22.20 11.47 26 855803 9811 109723659
Eye discharge 22.15 11.47 21 855808 8733 109724737
Defaecation urgency 22.11 11.47 21 855808 8726 109724744
Peripheral ischaemia 22.10 11.47 32 855797 11026 109722444
Neuromyelitis optica spectrum disorder 22.05 11.47 41 855788 1474 109731996
Rash pustular 22.02 11.47 41 855788 12788 109720682
Blood test abnormal 22.01 11.47 130 855699 28424 109705046
Haemolysis 22.00 11.47 201 855628 15438 109718032
Blood magnesium decreased 21.97 11.47 80 855749 19916 109713554
Tongue oedema 21.85 11.47 19 855810 8237 109725233
Campylobacter gastroenteritis 21.83 11.47 47 855782 1882 109731588
Nocardiosis 21.78 11.47 115 855714 7371 109726099
Adrenocortical insufficiency acute 21.76 11.47 4 855825 4436 109729034
Neuralgia 21.72 11.47 255 855574 48223 109685247
Insomnia 21.62 11.47 2451 853378 358139 109375331
Brain death 21.54 11.47 12 855817 6561 109726909
Thyroiditis 21.54 11.47 12 855817 6561 109726909
Myocarditis 21.53 11.47 140 855689 29915 109703555
Depressive symptom 21.51 11.47 20 855809 8394 109725076
Infection reactivation 21.45 11.47 75 855754 4006 109729464
Meningitis enteroviral 21.45 11.47 12 855817 90 109733380
Ocular icterus 21.40 11.47 10 855819 6043 109727427
Neck deformity 21.40 11.47 46 855783 1840 109731630
Microscopic polyangiitis 21.38 11.47 23 855806 490 109732980
Flushing 21.31 11.47 632 855197 104104 109629366
Internal haemorrhage 21.28 11.47 28 855801 10043 109723427
Hot flush 21.24 11.47 371 855458 65665 109667805
Vasculitis 21.22 11.47 393 855436 35480 109697990
Feeling drunk 21.19 11.47 8 855821 5492 109727978
Malignant syphilis 21.16 11.47 10 855819 50 109733420
Hyperphosphataemia 21.15 11.47 61 855768 16320 109717150
Product distribution issue 21.12 11.47 4 855825 4342 109729128
Pericardial haemorrhage 21.11 11.47 7 855822 5210 109728260
Duodenitis 21.08 11.47 24 855805 9172 109724298
Hypertensive crisis 20.96 11.47 107 855722 24265 109709205
Combined immunodeficiency 20.96 11.47 15 855814 180 109733290
Electrocardiogram ST segment depression 20.95 11.47 8 855821 5453 109728017
Cholecystectomy 20.90 11.47 32 855797 10777 109722693
B-cell lymphoma 20.89 11.47 110 855719 7044 109726426
Photopsia 20.86 11.47 11 855818 6203 109727267
Natural killer-cell leukaemia 20.81 11.47 12 855817 96 109733374
Breast cancer stage I 20.79 11.47 16 855813 7371 109726099
Haemophilus infection 20.78 11.47 58 855771 2742 109730728
Gingival pain 20.76 11.47 58 855771 15678 109717792
Total lung capacity abnormal 20.67 11.47 5 855824 4578 109728892
Myeloid leukaemia 20.65 11.47 30 855799 875 109732595
Abortion induced 20.57 11.47 19 855810 8000 109725470
Primary amyloidosis 20.48 11.47 18 855811 296 109733174
Spinal stenosis 20.44 11.47 77 855752 18979 109714491
Sepsis 20.40 11.47 2861 852968 324485 109408985
Physical disability 20.40 11.47 86 855743 5020 109728450
Plantar fasciitis 20.37 11.47 7 855822 5094 109728376
Bacterial test positive 20.34 11.47 19 855810 7958 109725512
Cheilitis 20.31 11.47 12 855817 6353 109727117
Neuroendocrine carcinoma of the skin 20.31 11.47 43 855786 1702 109731768
Wound dehiscence 20.26 11.47 19 855810 7943 109725527
Pneumothorax 20.21 11.47 175 855654 35110 109698360
Hepatic amoebiasis 20.21 11.47 12 855817 102 109733368
Scratch 20.13 11.47 44 855785 12935 109720535
Limb injury 20.10 11.47 190 855639 37446 109696024
Larynx irritation 20.09 11.47 15 855814 193 109733277
Cytomegalovirus oesophagitis 20.09 11.47 31 855798 955 109732515
Cryptococcosis 20.08 11.47 80 855749 4551 109728919
Scrotal cellulitis 20.05 11.47 11 855818 79 109733391
Neoplasm recurrence 20.03 11.47 87 855742 5145 109728325
Leukaemia cutis 20.02 11.47 16 855813 229 109733241
Gastric haemorrhage 20.02 11.47 60 855769 15855 109717615
Ecchymosis 19.96 11.47 68 855761 17270 109716200
Nodular regenerative hyperplasia 19.93 11.47 41 855788 1590 109731880
Pancreatic carcinoma metastatic 19.88 11.47 4 855825 4160 109729310
Immune-mediated enterocolitis 19.84 11.47 30 855799 10155 109723315
Subcutaneous drug absorption impaired 19.84 11.47 114 855715 7545 109725925
Increased tendency to bruise 19.81 11.47 38 855791 11720 109721750
Germ cell cancer 19.77 11.47 15 855814 198 109733272
Hypoalbuminaemia 19.73 11.47 137 855692 28837 109704633
Chondropathy 19.67 11.47 58 855771 2829 109730641
Bladder disorder 19.65 11.47 35 855794 11102 109722368
Chromosomal deletion 19.63 11.47 14 855815 167 109733303
Intraventricular haemorrhage 19.62 11.47 9 855820 5498 109727972
Peritonitis bacterial 19.59 11.47 32 855797 10501 109722969
Sacroiliitis 19.59 11.47 7 855822 4971 109728499
Bronchiectasis 19.59 11.47 184 855645 36309 109697161
Splenic infection 19.58 11.47 8 855821 26 109733444
Hair colour changes 19.57 11.47 6 855823 4695 109728775
Facial bones fracture 19.54 11.47 7 855822 4964 109728506
Ocular lymphoma 19.52 11.47 15 855814 202 109733268
Myelitis 19.51 11.47 62 855767 3151 109730319
Acquired C1 inhibitor deficiency 19.50 11.47 7 855822 14 109733456
Skin plaque 19.50 11.47 43 855786 12602 109720868
Emphysematous cholecystitis 19.45 11.47 12 855817 110 109733360
Opportunistic infection 19.40 11.47 66 855763 3477 109729993
Jaw disorder 19.39 11.47 8 855821 5204 109728266
Dysphagia 19.33 11.47 981 854848 152619 109580851
Catheter site infection 19.31 11.47 20 855809 7980 109725490
Aortic dissection 19.30 11.47 7 855822 4926 109728544
T-lymphocyte count decreased 19.25 11.47 24 855805 602 109732868
Electrocardiogram T wave inversion 19.15 11.47 10 855819 5670 109727800
Disseminated mucormycosis 19.14 11.47 47 855782 2055 109731415
Cryoglobulinaemia 19.10 11.47 35 855794 1244 109732226
Self-injurious ideation 19.10 11.47 5 855824 4341 109729129
Cartilage atrophy 19.09 11.47 14 855815 175 109733295
Bone density abnormal 19.04 11.47 70 855759 3833 109729637
Foetal exposure during pregnancy 19.00 11.47 18 855811 7487 109725983
Retroperitoneal haematoma 18.95 11.47 12 855817 6119 109727351
Pulmonary congestion 18.90 11.47 151 855678 30815 109702655
Hyperaesthesia 18.90 11.47 55 855774 14672 109718798
Catheter site haemorrhage 18.89 11.47 11 855818 5869 109727601
Echo virus infection 18.88 11.47 7 855822 16 109733454
Lung neoplasm malignant 18.87 11.47 169 855660 33673 109699797
Granulocyte count increased 18.76 11.47 45 855784 1938 109731532
Aortic arteriosclerosis 18.74 11.47 35 855794 10903 109722567
Intestinal perforation 18.73 11.47 246 855583 20698 109712772
Decubitus ulcer 18.72 11.47 75 855754 18161 109715309
Antineutrophil cytoplasmic antibody increased 18.69 11.47 17 855812 293 109733177
Bone marrow infiltration 18.69 11.47 28 855801 840 109732630
Erythropoiesis abnormal 18.68 11.47 24 855805 621 109732849
Bowel movement irregularity 18.66 11.47 19 855810 7641 109725829
Viral sepsis 18.64 11.47 15 855814 217 109733253
Oesophageal spasm 18.63 11.47 3 855826 3663 109729807
Hypoventilation 18.62 11.47 21 855808 8060 109725410
B-cell small lymphocytic lymphoma recurrent 18.59 11.47 7 855822 17 109733453
Borrelia infection 18.55 11.47 17 855812 296 109733174
Paronychia 18.51 11.47 36 855793 11045 109722425
Panic reaction 18.50 11.47 9 855820 5313 109728157
Lacunar infarction 18.49 11.47 13 855816 6273 109727197
Encephalitis 18.43 11.47 225 855604 18614 109714856
Atrial flutter 18.42 11.47 111 855718 24151 109709319
Upper-airway cough syndrome 18.39 11.47 62 855767 15795 109717675
Creatinine renal clearance increased 18.35 11.47 3 855826 3622 109729848
Intestinal resection 18.29 11.47 4 855825 3925 109729545
Electrocardiogram T wave abnormal 18.26 11.47 5 855824 4212 109729258
Granuloma 18.25 11.47 131 855698 9359 109724111
Glomerular filtration rate increased 18.25 11.47 44 855785 1901 109731569
Blood sodium increased 18.22 11.47 10 855819 5513 109727957
Allergic fungal rhinosinusitis 18.14 11.47 9 855820 51 109733419
Bilirubin conjugated increased 18.14 11.47 13 855816 6211 109727259
Peripheral T-cell lymphoma unspecified 18.13 11.47 28 855801 863 109732607
Diaphragm muscle weakness 18.13 11.47 14 855815 190 109733280
Intervertebral discitis 18.08 11.47 104 855725 6886 109726584
Application site pain 18.07 11.47 10 855819 5489 109727981
Pneumonia pseudomonal 18.05 11.47 110 855719 7436 109726034
Periorbital oedema 18.01 11.47 32 855797 10160 109723310
Partial seizures 17.99 11.47 38 855791 11311 109722159
Emphysema 17.99 11.47 85 855744 19671 109713799
Myeloproliferative neoplasm 17.97 11.47 36 855793 1369 109732101
Diverticulum intestinal 17.95 11.47 40 855789 11679 109721791
Anaemia macrocytic 17.92 11.47 18 855811 7285 109726185
Hyperviscosity syndrome 17.92 11.47 22 855807 543 109732927
Vascular stent thrombosis 17.89 11.47 5 855824 4156 109729314
Posture abnormal 17.88 11.47 6 855823 4432 109729038
Dermatitis 17.81 11.47 134 855695 27703 109705767
Intracranial pressure increased 17.79 11.47 34 855795 10501 109722969
Ocular discomfort 17.75 11.47 24 855805 8509 109724961
Renal tubular atrophy 17.74 11.47 48 855781 2228 109731242
Chylothorax 17.73 11.47 32 855797 1124 109732346
Frustration tolerance decreased 17.71 11.47 25 855804 8706 109724764
Endotracheal intubation 17.69 11.47 13 855816 6131 109727339
Pupil fixed 17.68 11.47 4 855825 3834 109729636
Primary immunodeficiency syndrome 17.66 11.47 10 855819 77 109733393
Gastric ulcer 17.65 11.47 210 855619 39617 109693853
Sweat gland tumour 17.64 11.47 22 855807 552 109732918
B-lymphocyte abnormalities 17.62 11.47 13 855816 164 109733306
Respiratory distress 17.62 11.47 402 855427 68472 109664998
Precancerous cells present 17.59 11.47 34 855795 1259 109732211
Herpes zoster infection neurological 17.59 11.47 21 855808 503 109732967
Formication 17.53 11.47 11 855818 5637 109727833
Stress cardiomyopathy 17.52 11.47 63 855766 15743 109717727
Urine abnormality 17.52 11.47 27 855802 9069 109724401
Labelled drug-drug interaction issue 17.50 11.47 5 855824 4096 109729374
Feeling of despair 17.42 11.47 4 855825 3794 109729676
Acute coronary syndrome 17.41 11.47 106 855723 23006 109710464
Anticoagulation drug level above therapeutic 17.40 11.47 7 855822 4623 109728847
Allergy to chemicals 17.39 11.47 61 855768 3264 109730206
Duodenal ulcer haemorrhage 17.33 11.47 22 855807 8015 109725455
Blood urine present 17.33 11.47 113 855716 24132 109709338
Pre-eclampsia 17.32 11.47 25 855804 8625 109724845
Ulcer haemorrhage 17.31 11.47 258 855571 22313 109711157
Scab 17.30 11.47 49 855780 13187 109720283
Hypotonia 17.29 11.47 63 855766 15682 109717788
Metastatic lymphoma 17.21 11.47 23 855806 619 109732851
Musculoskeletal discomfort 17.19 11.47 109 855720 23429 109710041
Liver transplant 17.15 11.47 7 855822 4582 109728888
Superinfection bacterial 17.10 11.47 49 855780 2352 109731118
Thermal burn 17.09 11.47 22 855807 7966 109725504
Pneumonia acinetobacter 17.05 11.47 18 855811 375 109733095
Pneumonia fungal 17.04 11.47 182 855647 14572 109718898
Arrhythmogenic right ventricular dysplasia 17.04 11.47 10 855819 83 109733387
Cardiac tamponade 16.99 11.47 39 855790 11268 109722202
Nodal rhythm 16.96 11.47 3 855826 3420 109730050
Gastroenteritis viral 16.95 11.47 157 855672 31069 109702401
Renal artery stenosis 16.93 11.47 4 855825 3722 109729748
Blood lactate dehydrogenase abnormal 16.91 11.47 23 855806 630 109732840
Neutrophil Pelger-Huet anomaly present 16.90 11.47 18 855811 379 109733091
Herpes simplex reactivation 16.88 11.47 36 855793 1432 109732038
Overlap syndrome 16.82 11.47 124 855705 8935 109724535
Renal function test abnormal 16.81 11.47 27 855802 8919 109724551
Lumbar spinal stenosis 16.79 11.47 15 855814 6418 109727052
Obstruction 16.78 11.47 12 855817 5740 109727730
Hepatomegaly 16.77 11.47 97 855732 21317 109712153
Mucosal dryness 16.76 11.47 6 855823 4257 109729213
Glottis carcinoma 16.72 11.47 6 855823 12 109733458
Plasmacytoma 16.68 11.47 10 855819 5252 109728218
Blood stem cell transplant failure 16.67 11.47 24 855805 694 109732776
Faciobrachial dystonic seizure 16.65 11.47 10 855819 87 109733383
Lymphadenitis viral 16.65 11.47 10 855819 87 109733383
Sinus arrest 16.63 11.47 6 855823 4236 109729234
Klebsiella sepsis 16.63 11.47 70 855759 4083 109729387
Maternal exposure during breast feeding 16.61 11.47 6 855823 4232 109729238
Glossitis 16.60 11.47 7 855822 4494 109728976
Infusion site erythema 16.59 11.47 43 855786 11916 109721554
Retching 16.58 11.47 105 855724 22577 109710893
Lower gastrointestinal haemorrhage 16.56 11.47 80 855749 18406 109715064
Oral candidiasis 16.55 11.47 245 855584 44515 109688955
Abdominal abscess 16.54 11.47 121 855708 8698 109724772
Myopathy 16.52 11.47 119 855710 24841 109708629
Ileus 16.47 11.47 155 855674 30574 109702896
Myelopathy 16.46 11.47 86 855743 5490 109727980
Cerebral ischaemia 16.43 11.47 44 855785 12060 109721410
Immunosuppressant drug level increased 16.38 11.47 42 855787 11682 109721788
Crystal nephropathy 16.37 11.47 41 855788 1815 109731655
Haematocrit increased 16.33 11.47 9 855820 4950 109728520
CD8 lymphocytes increased 16.32 11.47 8 855821 44 109733426
End stage renal disease 16.29 11.47 245 855584 21228 109712242
Chronic hepatitis B 16.27 11.47 21 855808 546 109732924
Catheter placement 16.25 11.47 3 855826 3317 109730153
Red blood cells urine positive 16.23 11.47 10 855819 5175 109728295
Body height decreased 16.22 11.47 36 855793 10527 109722943
Hyperthermia malignant 16.19 11.47 5 855824 3895 109729575
Macrocytosis 16.16 11.47 3 855826 3304 109730166
Plasma cells decreased 16.14 11.47 9 855820 67 109733403
Vitamin D decreased 16.13 11.47 45 855784 12170 109721300
Neck mass 16.10 11.47 77 855752 4744 109728726
Thrombotic microangiopathy 16.10 11.47 316 855513 28833 109704637
Viral mutation identified 16.09 11.47 7 855822 4412 109729058
Personality disorder 16.08 11.47 161 855668 12676 109720794
Rheumatoid lung 16.05 11.47 71 855758 4233 109729237
Vulvovaginal candidiasis 16.01 11.47 3 855826 3282 109730188
Gastritis bacterial 16.01 11.47 21 855808 555 109732915
Urinary hesitation 16.01 11.47 8 855821 4650 109728820
Vasogenic cerebral oedema 16.00 11.47 46 855783 2212 109731258
Vulvovaginal mycotic infection 15.98 11.47 11 855818 5366 109728104
ADAMTS13 activity decreased 15.96 11.47 16 855813 313 109733157
Body mass index abnormal 15.94 11.47 27 855802 901 109732569
Enterovirus myocarditis 15.92 11.47 5 855824 5 109733465
Linear IgA disease 15.91 11.47 7 855822 4382 109729088
Pulmonary arterial pressure increased 15.90 11.47 10 855819 5117 109728353
Hyperventilation 15.89 11.47 28 855801 8919 109724551
Lymphoproliferative disorder 15.89 11.47 103 855726 7115 109726355
Focal dyscognitive seizures 15.86 11.47 5 855824 3844 109729626
Gastric ulcer haemorrhage 15.83 11.47 34 855795 10060 109723410
Adenoviral haemorrhagic cystitis 15.83 11.47 23 855806 671 109732799
Epstein-Barr virus test positive 15.81 11.47 33 855796 1293 109732177
Renal cancer 15.78 11.47 50 855779 12984 109720486
Blood bicarbonate decreased 15.76 11.47 13 855816 5784 109727686
Metabolic syndrome 15.75 11.47 3 855826 3244 109730226
Mycoplasma infection 15.75 11.47 34 855795 1364 109732106
Stenotrophomonas bacteraemia 15.74 11.47 15 855814 275 109733195
Hepatocellular carcinoma 15.73 11.47 33 855796 9847 109723623
Cell death 15.73 11.47 13 855816 5778 109727692
Abdominal lymphadenopathy 15.72 11.47 40 855789 1788 109731682
Hypertensive heart disease 15.63 11.47 8 855821 4588 109728882
Cold sweat 15.59 11.47 103 855726 21928 109711542
Torticollis 15.58 11.47 3 855826 3218 109730252
Noninfectious myelitis 15.54 11.47 6 855823 16 109733454
Anti-aquaporin-4 antibody positive 15.48 11.47 4 855825 0 109733470
Acute flaccid myelitis 15.48 11.47 4 855825 0 109733470
Phospholipase A2 activity increased 15.48 11.47 4 855825 0 109733470
Intervertebral disc disorder 15.44 11.47 12 855817 5500 109727970
Immune-mediated myocarditis 15.42 11.47 4 855825 3494 109729976
Large intestinal stenosis 15.42 11.47 5 855824 3775 109729695
Enteritis 15.42 11.47 86 855743 19070 109714400
Mycotic allergy 15.40 11.47 14 855815 5940 109727530
Tic 15.39 11.47 4 855825 3489 109729981
Polycystic ovaries 15.37 11.47 9 855820 4787 109728683
Regurgitation 15.34 11.47 4 855825 3481 109729989
Immunisation 15.32 11.47 3 855826 3180 109730290
Bronchial secretion retention 15.30 11.47 10 855819 5014 109728456
Osteonecrosis 15.30 11.47 177 855652 33564 109699906
Disorder of orbit 15.30 11.47 11 855818 133 109733337
Blood immunoglobulin A increased 15.28 11.47 36 855793 1532 109731938
Urine odour abnormal 15.27 11.47 21 855808 7394 109726076
Diffuse large B-cell lymphoma stage IV 15.26 11.47 26 855803 872 109732598
Appetite disorder 15.25 11.47 33 855796 9736 109723734
Snoring 15.23 11.47 18 855811 6766 109726704
Tumour haemorrhage 15.23 11.47 11 855818 5234 109728236
Haemodynamic instability 15.21 11.47 109 855720 22779 109710691
Pupillary reflex impaired 15.21 11.47 6 855823 4009 109729461
Schistocytosis 15.20 11.47 9 855820 76 109733394
Metabolic disorder 15.19 11.47 37 855792 10473 109722997
Scar 15.16 11.47 73 855756 16808 109716662
Blood potassium abnormal 15.14 11.47 6 855823 3999 109729471
Tenderness 15.13 11.47 150 855679 29287 109704183
Spinal compression fracture 15.12 11.47 82 855747 18310 109715160
Blood parathyroid hormone increased 15.05 11.47 7 855822 4241 109729229
Extranodal marginal zone B-cell lymphoma (MALT type) recurrent 15.04 11.47 6 855823 18 109733452
Refractory cytopenia with multilineage dysplasia 15.03 11.47 14 855815 249 109733221
Disinhibition 14.98 11.47 3 855826 3131 109730339
Cestode infection 14.98 11.47 15 855814 293 109733177
Varicose vein 14.97 11.47 19 855810 6921 109726549
B-lymphocyte count increased 14.96 11.47 11 855818 138 109733332
Escherichia sepsis 14.95 11.47 133 855696 10139 109723331
Proteus infection 14.89 11.47 52 855777 2776 109730694
Cardiomyopathy 14.84 11.47 352 855477 33173 109700297
Fat embolism syndrome 14.83 11.47 11 855818 140 109733330
Oesophageal carcinoma 14.82 11.47 43 855786 11481 109721989
Genitourinary tract infection 14.81 11.47 15 855814 297 109733173
Central nervous system fungal infection 14.78 11.47 21 855808 600 109732870
Peripheral arterial occlusive disease 14.77 11.47 31 855798 9249 109724221
Skin hyperpigmentation 14.74 11.47 28 855801 8668 109724802
Energy increased 14.74 11.47 5 855824 3669 109729801
Scleroderma renal crisis 14.73 11.47 26 855803 897 109732573
Ureteric compression 14.73 11.47 15 855814 299 109733171
Infected seroma 14.73 11.47 9 855820 81 109733389
Mycoplasma test positive 14.72 11.47 14 855815 256 109733214
Foot operation 14.68 11.47 102 855727 7211 109726259
Chest X-ray abnormal 14.68 11.47 27 855802 8460 109725010
Pelvic fracture 14.66 11.47 58 855771 14096 109719374
Throat tightness 14.64 11.47 351 855478 33138 109700332
Leukaemic lymphoma 14.64 11.47 9 855820 82 109733388
Sinus node dysfunction 14.59 11.47 30 855799 9017 109724453
Thyroid function test abnormal 14.56 11.47 4 855825 3363 109730107
Myeloid maturation arrest 14.52 11.47 8 855821 58 109733412
Intestinal ischaemia 14.51 11.47 70 855759 16109 109717361
Ischaemic hepatitis 14.50 11.47 9 855820 4639 109728831
Nail operation 14.50 11.47 37 855792 1657 109731813
Ureterolithiasis 14.48 11.47 8 855821 4394 109729076
Protein total decreased 14.47 11.47 40 855789 10850 109722620
Spinal osteoarthritis 14.46 11.47 94 855735 20089 109713381
Cardiac valve disease 14.46 11.47 17 855812 6404 109727066
Fluoride increased 14.46 11.47 9 855820 84 109733386
Cough 14.42 11.47 3257 852572 458384 109275086
Epidermal necrosis 14.42 11.47 3 855826 3047 109730423
Neurological decompensation 14.41 11.47 97 855732 6786 109726684
Device infusion issue 14.38 11.47 3 855826 3042 109730428
Hypocholesterolaemia 14.36 11.47 92 855737 6329 109727141
Haemorrhage subcutaneous 14.36 11.47 13 855816 5526 109727944
Fluid retention 14.35 11.47 590 855239 93717 109639753
Ejection fraction decreased 14.35 11.47 226 855603 40654 109692816
Cardiac flutter 14.35 11.47 14 855815 5743 109727727
Blood pressure abnormal 14.32 11.47 108 855721 22316 109711154
Nasal discomfort 14.31 11.47 16 855813 6165 109727305
Klebsiella bacteraemia 14.31 11.47 75 855754 4794 109728676
Monoclonal gammopathy 14.26 11.47 30 855799 1182 109732288
Sternal fracture 14.23 11.47 4 855825 3312 109730158
Food poisoning 14.21 11.47 17 855812 6355 109727115
General symptom 14.17 11.47 117 855712 8729 109724741
Disorganised speech 14.14 11.47 4 855825 3299 109730171
Visual field defect 14.14 11.47 36 855793 10036 109723434
Uveitis 14.13 11.47 104 855725 21606 109711864
Ligament sprain 14.13 11.47 70 855759 15998 109717472
Language disorder 14.11 11.47 6 855823 3832 109729638
Nephrogenic anaemia 14.09 11.47 9 855820 4568 109728902
Pneumonia escherichia 14.06 11.47 30 855799 1194 109732276
Diabetic retinopathy 14.04 11.47 5 855824 3559 109729911
Tongue discolouration 14.04 11.47 7 855822 4074 109729396
Bone marrow necrosis 14.02 11.47 17 855812 414 109733056
Left atrial dilatation 14.02 11.47 5 855824 3555 109729915
Compartment syndrome 14.01 11.47 15 855814 5895 109727575
Mouth swelling 14.00 11.47 22 855807 7332 109726138
Disseminated blastomycosis 13.97 11.47 18 855811 467 109733003
T-lymphocyte count increased 13.97 11.47 13 855816 231 109733239
Cholangitis 13.89 11.47 72 855757 16263 109717207
Mastication disorder 13.88 11.47 5 855824 3533 109729937
Intestinal atresia 13.87 11.47 8 855821 64 109733406
Device physical property issue 13.83 11.47 6 855823 3788 109729682
Mucocutaneous haemorrhage 13.83 11.47 14 855815 277 109733193
Aspartate aminotransferase 13.83 11.47 26 855803 943 109732527
Hepatitis B core antibody positive 13.82 11.47 21 855808 638 109732832
Hereditary angioedema 13.82 11.47 21 855808 7093 109726377
Eosinophilic cystitis 13.79 11.47 11 855818 157 109733313
Viral cardiomyopathy 13.79 11.47 7 855822 42 109733428
Hyperacusis 13.76 11.47 3 855826 2949 109730521
Viral upper respiratory tract infection 13.75 11.47 130 855699 10078 109723392
Procedural haemorrhage 13.75 11.47 13 855816 5414 109728056
Citrobacter bacteraemia 13.75 11.47 6 855823 24 109733446
Helicobacter sepsis 13.75 11.47 6 855823 24 109733446
Seminoma 13.71 11.47 14 855815 280 109733190
Ischaemic cerebral infarction 13.71 11.47 3 855826 2942 109730528
Diabetic nephropathy 13.69 11.47 5 855824 3503 109729967
Tongue biting 13.67 11.47 3 855826 2936 109730534
Tularaemia 13.67 11.47 12 855817 197 109733273
Serum sickness-like reaction 13.63 11.47 23 855806 765 109732705
Throat clearing 13.61 11.47 68 855761 4265 109729205
Positron emission tomogram abnormal 13.60 11.47 18 855811 480 109732990
Attention deficit hyperactivity disorder 13.60 11.47 9 855820 4482 109728988
Carbon dioxide decreased 13.60 11.47 10 855819 4714 109728756
Muscle fatigue 13.59 11.47 7 855822 4000 109729470
Staphylococcal sepsis 13.58 11.47 200 855629 17254 109716216
Gallbladder disorder 13.56 11.47 101 855728 20928 109712542
Faeces hard 13.56 11.47 8 855821 4238 109729232
Capnocytophaga sepsis 13.56 11.47 6 855823 25 109733445
Intestinal stenosis 13.55 11.47 10 855819 4705 109728765
Oesophageal stenosis 13.53 11.47 12 855817 5153 109728317
Rosai-Dorfman syndrome 13.52 11.47 7 855822 44 109733426
Bronchial wall thickening 13.52 11.47 4 855825 3203 109730267
Ileal perforation 13.49 11.47 32 855797 1368 109732102
Eosinophil count decreased 13.48 11.47 16 855813 6002 109727468
Skin weeping 13.47 11.47 6 855823 3729 109729741
Abdominal pain upper 13.45 11.47 2437 853392 346674 109386796
Conjunctival haemorrhage 13.45 11.47 19 855810 6614 109726856
Adenocarcinoma gastric 13.44 11.47 41 855788 2038 109731432
Hepatic pain 13.40 11.47 10 855819 4680 109728790
Neck pain 13.40 11.47 1117 854712 122013 109611457
Ejection fraction abnormal 13.39 11.47 5 855824 3455 109730015
Tender joint count 13.39 11.47 32 855797 1375 109732095
Knee operation 13.38 11.47 21 855808 7001 109726469
Therapy responder 13.38 11.47 17 855812 435 109733035
Hyperkinesia 13.37 11.47 4 855825 3180 109730290
Foetal death 13.33 11.47 186 855643 15859 109717611
Pulmonary thrombosis 13.31 11.47 165 855664 13698 109719772
Cyst 13.31 11.47 74 855755 16422 109717048
Lymphocytic lymphoma 13.30 11.47 9 855820 98 109733372
Gastrooesophageal reflux disease 13.29 11.47 1205 854624 178771 109554699
Intermittent claudication 13.26 11.47 6 855823 3695 109729775
Laryngeal pain 13.26 11.47 16 855813 5959 109727511
Haemophilus test positive 13.25 11.47 10 855819 131 109733339
Angiolymphoid hyperplasia with eosinophilia 13.25 11.47 10 855819 131 109733339
Meningitis meningococcal 13.23 11.47 12 855817 206 109733264
Abdominal adhesions 13.23 11.47 8 855821 4182 109729288
Cytokine storm 13.23 11.47 33 855796 1457 109732013
Multiple-drug resistance 13.23 11.47 55 855774 13180 109720290
Rheumatoid factor 13.21 11.47 19 855810 549 109732921
Failure to thrive 13.20 11.47 57 855772 13517 109719953
Nasal cavity cancer 13.17 11.47 14 855815 294 109733176
Pneumonia respiratory syncytial viral 13.16 11.47 49 855780 2700 109730770
Disseminated cytomegaloviral infection 13.15 11.47 20 855809 608 109732862
Abdominal rigidity 13.14 11.47 6 855823 3674 109729796
Systemic infection 13.10 11.47 36 855793 9783 109723687
Pulmonary vasculitis 13.09 11.47 19 855810 6541 109726929
Cytomegalovirus enteritis 13.05 11.47 27 855802 1051 109732419
Respiratory alkalosis 13.04 11.47 15 855814 5706 109727764
Hypopituitarism 13.02 11.47 9 855820 4381 109729089
Superior mesenteric artery syndrome 13.00 11.47 12 855817 211 109733259
Squamous cell carcinoma 12.99 11.47 208 855621 18255 109715215
Allergic oedema 12.99 11.47 25 855804 923 109732547
Distributive shock 12.90 11.47 16 855813 5888 109727582
Periostitis 12.90 11.47 23 855806 800 109732670
Mucosal erosion 12.90 11.47 3 855826 2821 109730649
Respiratory rate increased 12.88 11.47 269 855560 24814 109708656
Raoultella ornithinolytica infection 12.86 11.47 11 855818 174 109733296
Hyperthermia 12.86 11.47 104 855725 21168 109712302
Anxiety disorder 12.86 11.47 12 855817 5028 109728442
Haemangioma 12.84 11.47 3 855826 2813 109730657
Vitamin B12 increased 12.80 11.47 40 855789 2015 109731455
Urine analysis abnormal 12.79 11.47 21 855808 6876 109726594
Parechovirus infection 12.78 11.47 5 855824 14 109733456
Hepatic necrosis 12.77 11.47 37 855792 9885 109723585
Faeces pale 12.74 11.47 5 855824 3352 109730118
Vulval ulceration 12.73 11.47 14 855815 306 109733164
Yellow skin 12.72 11.47 8 855821 4094 109729376
Stoma site discharge 12.70 11.47 3 855826 2792 109730678
Bacille Calmette-Guerin scar reactivation 12.70 11.47 6 855823 30 109733440
Anaplastic thyroid cancer 12.68 11.47 7 855822 51 109733419
Tetany 12.67 11.47 6 855823 3598 109729872
Dilatation atrial 12.67 11.47 7 855822 3845 109729625
Urine ketone body present 12.63 11.47 7 855822 3839 109729631
Respiratory rate decreased 12.62 11.47 18 855811 6240 109727230
Ganglioneuroma 12.58 11.47 10 855819 142 109733328
Extranodal marginal zone B-cell lymphoma (MALT type) 12.57 11.47 22 855807 754 109732716
Varicella 12.56 11.47 60 855769 3695 109729775
Hypovolaemic shock 12.55 11.47 64 855765 14519 109718951
SARS-CoV-2 viraemia 12.52 11.47 10 855819 143 109733327
Biliary fistula 12.52 11.47 10 855819 143 109733327
Toxoplasmosis 12.51 11.47 54 855775 3185 109730285
Blood magnesium increased 12.50 11.47 7 855822 3816 109729654
Rheumatic disorder 12.47 11.47 58 855771 3533 109729937
Kidney fibrosis 12.46 11.47 67 855762 4325 109729145
Unintentional medical device removal 12.44 11.47 32 855797 8891 109724579
Haemorrhagic transformation stroke 12.42 11.47 4 855825 3033 109730437
Passenger lymphocyte syndrome 12.41 11.47 11 855818 183 109733287
Leukaemic infiltration 12.41 11.47 11 855818 183 109733287
Thyroid cancer 12.40 11.47 18 855811 6196 109727274
Tongue disorder 12.39 11.47 167 855662 14131 109719339
Seroma 12.39 11.47 5 855824 3296 109730174
Product use complaint 12.38 11.47 7 855822 3796 109729674
Complement factor C3 decreased 12.35 11.47 15 855814 366 109733104
Cerebral atrophy 12.35 11.47 33 855796 9052 109724418
Mean cell volume decreased 12.33 11.47 81 855748 5621 109727849
Inhibiting antibodies 12.30 11.47 5 855824 16 109733454
Rash morbilliform 12.29 11.47 27 855802 7924 109725546
Premenstrual syndrome 12.27 11.47 19 855810 587 109732883
Injection site haematoma 12.27 11.47 13 855816 5133 109728337
Hyperglycaemic hyperosmolar nonketotic syndrome 12.24 11.47 4 855825 3005 109730465
Acute myeloid leukaemia recurrent 12.23 11.47 13 855816 5126 109728344
Blood uric acid increased 12.23 11.47 107 855722 21422 109712048
Anaemia of chronic disease 12.21 11.47 5 855824 3267 109730203
Facial paralysis 12.19 11.47 124 855705 24090 109709380
Acute graft versus host disease in skin 12.18 11.47 132 855697 10608 109722862
Localised oedema 12.16 11.47 34 855795 9189 109724281
Angina pectoris 12.15 11.47 378 855451 61917 109671553
Alanine aminotransferase abnormal 12.15 11.47 118 855711 9216 109724254
Mean cell haemoglobin decreased 12.09 11.47 96 855733 7078 109726392
Testicular neoplasm 12.07 11.47 5 855824 17 109733453
Rebound effect 12.05 11.47 171 855658 14635 109718835
Eye movement disorder 12.00 11.47 37 855792 9691 109723779
Tendon rupture 12.00 11.47 62 855767 14016 109719454
Choking sensation 12.00 11.47 10 855819 4426 109729044
Decreased activity 11.99 11.47 44 855785 10930 109722540
Morphoea 11.99 11.47 19 855810 599 109732871
Neoplasm 11.99 11.47 135 855694 10952 109722518
Foot fracture 11.98 11.47 133 855696 25413 109708057
Total lung capacity decreased 11.98 11.47 23 855806 7091 109726379
Biopsy bone marrow abnormal 11.98 11.47 17 855812 485 109732985
Abdominal wall haematoma 11.91 11.47 16 855813 5689 109727781
Oropharyngeal squamous cell carcinoma 11.90 11.47 14 855815 330 109733140
Echocardiogram abnormal 11.90 11.47 3 855826 2671 109730799
Gastroenteritis clostridial 11.90 11.47 26 855803 1052 109732418
Lung transplant 11.90 11.47 14 855815 5272 109728198
Intervertebral disc space narrowing 11.90 11.47 37 855792 1859 109731611
Smear cervix abnormal 11.88 11.47 47 855782 2665 109730805
Pulmonary nocardiosis 11.87 11.47 46 855783 2583 109730887
Follicle centre lymphoma, follicular grade I, II, III recurrent 11.86 11.47 4 855825 6 109733464
Prolymphocytic leukaemia 11.86 11.47 4 855825 6 109733464
Haemoglobin increased 11.86 11.47 34 855795 9113 109724357
Macule 11.85 11.47 7 855822 3706 109729764
Splenic candidiasis 11.83 11.47 8 855821 87 109733383
Cytomegalovirus gastritis 11.79 11.47 20 855809 668 109732802
Spondylitis 11.79 11.47 137 855692 11201 109722269
Skin induration 11.77 11.47 10 855819 4385 109729085
Asthma 11.76 11.47 2154 853675 248137 109485333
Resuscitation 11.75 11.47 4 855825 2929 109730541
Skin toxicity 11.75 11.47 49 855780 11734 109721736
Slow speech 11.73 11.47 6 855823 3442 109730028
Arthritis reactive 11.70 11.47 22 855807 798 109732672
Kyphosis 11.68 11.47 5 855824 3182 109730288
Infusion site haemorrhage 11.67 11.47 11 855818 4587 109728883
Pleuritic pain 11.65 11.47 75 855754 16065 109717405
Sensory loss 11.64 11.47 232 855597 21225 109712245
Retinitis viral 11.63 11.47 16 855813 443 109733027
Breath sounds abnormal 11.62 11.47 133 855696 25271 109708199
Hepatitis B core antigen positive 11.61 11.47 3 855826 0 109733470
Human anti-mouse antibody positive 11.61 11.47 3 855826 0 109733470
Echovirus test positive 11.61 11.47 3 855826 0 109733470
Lower respiratory tract herpes infection 11.61 11.47 3 855826 0 109733470
EZH2 gene mutation 11.61 11.47 3 855826 0 109733470
Haemothorax 11.61 11.47 23 855806 7008 109726462
Donor specific antibody present 11.59 11.47 15 855814 391 109733079
Polyp 11.59 11.47 39 855790 9941 109723529
Platelet distribution width decreased 11.56 11.47 6 855823 38 109733432
Asthenopia 11.54 11.47 5 855824 3159 109730311
Mallory-Weiss syndrome 11.52 11.47 5 855824 3156 109730314
Henoch-Schonlein purpura 11.52 11.47 7 855822 3650 109729820
Synovial disorder 11.51 11.47 50 855779 2957 109730513
Hypocoagulable state 11.51 11.47 3 855826 2612 109730858
Disease complication 11.51 11.47 17 855812 5810 109727660
Ovarian cyst 11.51 11.47 62 855767 13868 109719602
Herpes simplex test positive 11.50 11.47 19 855810 621 109732849
Appendicitis perforated 11.49 11.47 7 855822 3645 109729825
Engraftment syndrome 11.48 11.47 37 855792 1895 109731575

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
CD20 (Clusters of Differentiation 20) inhibitors
FDA MoA N0000175078 CD20-directed Antibody Interactions
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D018501 Antirheumatic Agents
FDA EPC N0000175657 CD20-directed Cytolytic Antibody

Related Drugs by ATC class:

L01FA CD20 (Clusters of Differentiation 20) inhibitors 2 drugs
obinutuzumabofatumumab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Burkitt cell leukemia indication 22197008
Neuromyelitis optica indication 25044007 DOID:8869
Pemphigus foliaceus indication 35154004
Pemphigus vulgaris indication 49420001 DOID:0060851
Follicular lymphoma indication 55150002
Lupus nephritis indication 68815009
Rheumatoid arthritis indication 69896004 DOID:7148
Burkitt's lymphoma indication 77381001 DOID:8584
Thrombotic thrombocytopenic purpura indication 78129009 DOID:10772
Systemic sclerosis indication 89155008 DOID:418
Chronic lymphoid leukemia, disease indication 92814006
CD20 positive diffuse large B cell non Hodgkin's lymphoma indication 109969005
Non-Hodgkin's lymphoma indication 118601006
Granulomatosis with polyangiitis indication 195353004 DOID:12132
Refractory nephrotic syndrome indication 236381000
Microscopic polyarteritis nodosa indication 239928004
Microscopic polyangiitis indication 1144805008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
B-lymphocyte antigen CD20 Surface antigen ANTIBODY BINDING Kd 8.51 IUPHAR DRUG LABEL

External reference:

IDSource
D02994 KEGG_DRUG
4021104 VUID
N0000148560 NUI
4021104 VANDF
CHEMBL1201576 ChEMBL_ID
6780 IUPHAR_LIGAND_ID
DB00073 DRUGBANK_ID
121191 RXNORM
11468 MMSL
5432 MMSL
d04255 MMSL
007236 NDDF
108809004 SNOMEDCT_US
386919002 SNOMEDCT_US
C0393022 UMLSCUI
D000069283 MESH_DESCRIPTOR_UI
7609 INN_ID
4F4X42SYQ6 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0238 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Ruxience HUMAN PRESCRIPTION DRUG LABEL 1 0069-0249 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-051 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan HUMAN PRESCRIPTION DRUG LABEL 1 50242-053 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 32 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-108 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Rituxan Hycela HUMAN PRESCRIPTION DRUG LABEL 2 50242-109 INJECTION, SOLUTION 120 mg SUBCUTANEOUS BLA 29 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-224 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 32 sections
Riabni HUMAN PRESCRIPTION DRUG LABEL 1 55513-326 INJECTION, SOLUTION 500 mg INTRAVENOUS BLA 32 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-103 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections
Truxima HUMAN PRESCRIPTION DRUG LABEL 1 63459-104 INJECTION, SOLUTION 10 mg INTRAVENOUS BLA 29 sections