Stem definition | Drug id | CAS RN |
---|---|---|
histone deacetylase inhibitors | 4973 | 743420-02-2 |
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None
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 23, 2014 | China Food and Drug Administration (CFDA) | ||
June 23, 2021 | PMDA | HUYA JAPAN G.K. |
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None
None
None
None
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Peripheral T-cell lymphoma | indication | 109977009 | |
Relapsed or refractory T-cell leukemia-lymphoma | indication | 110007008 | DOID:5603 |
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Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.63 | acidic |
pKa2 | 11.87 | acidic |
pKa3 | 4.26 | Basic |
pKa4 | 3.32 | Basic |
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Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 2 | Enzyme | INHIBITOR | IC50 | 6.80 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Histone deacetylase 1 | Enzyme | INHIBITOR | IC50 | 7.02 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Histone deacetylase 3 | Enzyme | INHIBITOR | IC50 | 7.17 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Histone deacetylase 10 | Enzyme | INHIBITOR | IC50 | 7.11 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Histone deacetylase 8 | Enzyme | INHIBITOR | IC50 | 6.14 | SCIENTIFIC LITERATURE | ||||
Histone deacetylase 11 | Enzyme | INHIBITOR | IC50 | 6.37 | SCIENTIFIC LITERATURE | ||||
Nicotinamide phosphoribosyltransferase | Enzyme | IC50 | 5.68 | CHEMBL |
ID | Source |
---|---|
87CIC980Y0 | UNII |
C2932486 | UMLSCUI |
CHEBI:135918 | CHEBI |
CHEMBL3621988 | ChEMBL_ID |
12136798 | PUBCHEM_CID |
DB06334 | DRUGBANK_ID |
8305 | IUPHAR_LIGAND_ID |
C000613826 | MESH_SUPPLEMENTAL_RECORD_UI |
D10993 | KEGG_DRUG |
10318 | INN_ID |
1616493-44-7 | SECONDARY_CAS_RN |
None