All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

eculizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
humanized origin	4969	219685-50-4

Description:

Molecule	Description
Synonyms: eculizumab soliris h5G1.1 h5G1.1VHC+h5G1.1VLC	a recombinant humanized monoclonal IgG2/4k antibody produced by murine myeloma cell culture, specifically binds to the complement protein C5 with high affinity, thereby inhibiting its cleavage to C5a and C5b and preventing the generation of the terminal complement complex C5b-9 Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
64	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
April 16, 2010	PMDA	Alexion Pharma
March 16, 2007	FDA	ALEXION PHARM
June 20, 2007	EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemolysis	616.91	17.18	171	18263	8339	90601674
Haemoglobin decreased	508.05	17.18	348	18086	161608	90448405
Thrombotic microangiopathy	473.61	17.18	161	18273	15582	90594431
Blood lactate dehydrogenase increased	374.87	17.18	155	18279	25777	90584236
Breakthrough haemolysis	268.94	17.18	46	18388	195	90609818
Extravascular haemolysis	220.06	17.18	41	18393	306	90609707
Exposure during pregnancy	216.25	17.18	254	18180	238156	90371857
Haemoglobinuria	211.90	17.18	39	18395	270	90609743
Platelet count decreased	169.52	17.18	172	18262	136797	90473216
Off label use	164.33	17.18	543	17891	1101709	89508304
Meningococcal sepsis	159.77	17.18	26	18408	75	90609938
Suspected COVID-19	140.97	17.18	42	18392	2644	90607369
Meningococcal bacteraemia	114.77	17.18	17	18417	19	90609994
Haptoglobin decreased	108.95	17.18	28	18406	1015	90608998
Myasthenia gravis crisis	108.39	17.18	28	18406	1036	90608977
Chromaturia	107.95	17.18	60	18374	19127	90590886
Poor venous access	106.96	17.18	60	18374	19467	90590546
Renal transplant failure	106.67	17.18	28	18406	1104	90608909
Reticulocyte count increased	102.78	17.18	27	18407	1068	90608945
Premature delivery	95.25	17.18	72	18362	38690	90571323
Renal impairment	94.81	17.18	112	18322	105309	90504704
Death	89.13	17.18	248	18186	456303	90153710
Aplastic anaemia	78.78	17.18	43	18391	13226	90596787
Atypical haemolytic uraemic syndrome	76.78	17.18	21	18413	970	90609043
Cytomegalovirus infection	73.41	17.18	53	18381	26549	90583464
Transfusion	72.80	17.18	45	18389	17443	90592570
Blood lactate dehydrogenase abnormal	72.06	17.18	17	18417	429	90609584
Pre-eclampsia	71.74	17.18	38	18396	11010	90599003
Incorrect dose administered	69.53	17.18	83	18351	78847	90531166
Intravascular haemolysis	67.08	17.18	16	18418	424	90609589
Multiple organ dysfunction syndrome	65.42	17.18	75	18359	68261	90541752
Polyomavirus-associated nephropathy	65.28	17.18	23	18411	2467	90607546
Anaemia	65.19	17.18	188	18246	352614	90257399
Arteriovenous fistula occlusion	64.46	17.18	15	18419	356	90609657
Bronchiolitis obliterans syndrome	62.94	17.18	15	18419	396	90609617
Total complement activity decreased	62.17	17.18	11	18423	59	90609954
Renal transplant	61.65	17.18	20	18414	1668	90608345
Inappropriate schedule of product administration	60.50	17.18	109	18325	149824	90460189
Posterior reversible encephalopathy syndrome	60.49	17.18	44	18390	22295	90587718
Gonorrhoea	60.14	17.18	12	18422	133	90609880
Sepsis	59.34	17.18	120	18314	179694	90430319
Blood creatinine increased	58.98	17.18	87	18347	101299	90508714
Proteinuria	58.84	17.18	44	18390	23247	90586766
Iron overload	58.04	17.18	17	18417	1008	90609005
Dyspnoea exertional	57.17	17.18	72	18362	72216	90537797
Drug intolerance	56.97	17.18	11	18423	447580	90162433
Transplant rejection	56.10	17.18	34	18400	12724	90597289
Meningitis meningococcal	55.45	17.18	11	18423	118	90609895
Blue toe syndrome	55.45	17.18	14	18420	472	90609541
Nephrectomy	54.63	17.18	19	18415	1962	90608051
Headache	53.91	17.18	329	18105	862417	89747596
Glossodynia	53.31	17.18	3	18431	321776	90288237
Cervicitis	53.28	17.18	14	18420	554	90609459
Rheumatoid arthritis	52.83	17.18	6	18428	362608	90247405
Bacteraemia	51.65	17.18	40	18394	22260	90587753
Haemoglobin abnormal	50.62	17.18	26	18408	7074	90602939
Plasmapheresis	49.50	17.18	12	18422	341	90609672
Product use issue	49.23	17.18	5	18429	329914	90280099
Platelet count abnormal	46.47	17.18	21	18413	4314	90605699
Swelling	46.09	17.18	14	18420	419044	90190969
Haematocrit decreased	45.34	17.18	49	18385	41783	90568230
Symptom recurrence	45.06	17.18	20	18414	3939	90606074
Drug hypersensitivity	43.44	17.18	20	18414	463589	90146424
Abdominal discomfort	42.58	17.18	22	18412	477306	90132707
Cytomegalovirus gastrointestinal infection	42.58	17.18	11	18423	407	90609606
Gonococcal infection	42.57	17.18	6	18428	3	90610010
Drug effective for unapproved indication	42.46	17.18	24	18410	7894	90602119
Alopecia	41.02	17.18	25	18409	495046	90114967
Meningitis	40.93	17.18	24	18410	8457	90601556
Joint swelling	40.90	17.18	26	18408	503274	90106739
Rash	40.68	17.18	62	18372	796038	89813975
Thrombocytopenia	40.21	17.18	113	18321	208612	90401401
Thrombosis	39.94	17.18	61	18373	73190	90536823
SARS-CoV-2 test positive	39.75	17.18	26	18408	11102	90598911
Drug interaction	39.20	17.18	5	18429	276448	90333565
Urinary tract infection bacterial	39.07	17.18	21	18413	6264	90603749
Pneumonia bacterial	38.79	17.18	27	18407	12763	90597250
Abortion spontaneous	38.29	17.18	51	18383	54005	90556008
Condition aggravated	38.28	17.18	229	18205	595316	90014697
Jaundice	36.84	17.18	39	18395	32478	90577535
Graft loss	36.84	17.18	10	18424	449	90609564
Stomatitis	36.55	17.18	6	18428	274692	90335321
Staphylococcal infection	36.32	17.18	47	18387	48392	90561621
Meningococcal infection	36.32	17.18	8	18426	147	90609866
Urinary tract infection	35.99	17.18	140	18294	305492	90304521
Wound	35.39	17.18	9	18425	302971	90307042
Total complement activity increased	35.15	17.18	5	18429	3	90610010
Fatigue	35.01	17.18	373	18061	1153650	89456363
Dysphagia	34.74	17.18	73	18361	112205	90497808
Maternal exposure during breast feeding	33.75	17.18	19	18415	6201	90603812
Transplantation complication	33.61	17.18	8	18426	210	90609803
Hepatic enzyme increased	33.10	17.18	16	18418	360720	90249293
End stage renal disease	33.02	17.18	21	18413	8550	90601463
Gastroenteritis	33.02	17.18	35	18399	29194	90580819
Therapeutic product effect decreased	32.89	17.18	8	18426	277563	90332450
Herpes simplex	32.07	17.18	22	18412	10159	90599854
Haemolytic anaemia	31.57	17.18	23	18411	11674	90598339
Type 2 diabetes mellitus	30.51	17.18	3	18431	203241	90406772
Renal failure	30.37	17.18	76	18358	130931	90479082
Polyomavirus viraemia	30.14	17.18	11	18423	1306	90608707
Wheezing	29.95	17.18	6	18428	238074	90371939
Pericarditis	29.72	17.18	9	18425	270142	90339871
Injury	29.40	17.18	3	18431	197346	90412667
Blood product transfusion dependent	29.36	17.18	7	18427	185	90609828
Impaired healing	29.25	17.18	6	18428	234193	90375820
Fungal peritonitis	29.17	17.18	9	18425	637	90609376
Blister	28.97	17.18	8	18426	254990	90355023
Pain	28.88	17.18	105	18329	996236	89613777
Septic shock	28.73	17.18	57	18377	84103	90525910
Red blood cell count decreased	28.72	17.18	41	18393	46310	90563703
Complement factor abnormal	28.39	17.18	5	18429	26	90609987
Pneumocystis jirovecii pneumonia	28.25	17.18	28	18406	21588	90588425
Arthritis bacterial	28.08	17.18	18	18416	7427	90602586
BK virus infection	27.88	17.18	15	18419	4483	90605530
Viral infection	27.70	17.18	38	18396	41376	90568637
Graft ischaemia	27.68	17.18	6	18428	102	90609911
Pneumonia adenoviral	27.61	17.18	7	18427	240	90609773
Renal pain	27.40	17.18	18	18416	7741	90602272
Treatment failure	27.09	17.18	14	18420	303914	90306099
Quality of life decreased	26.82	17.18	21	18413	11868	90598145
Small intestine gangrene	26.75	17.18	5	18429	38	90609975
Blood cholesterol increased	26.67	17.18	5	18429	208007	90402006
Osteoarthritis	26.66	17.18	4	18430	195726	90414287
Bone marrow transplant	26.64	17.18	9	18425	851	90609162
Babesiosis	26.62	17.18	7	18427	278	90609735
Delayed engraftment	26.35	17.18	6	18428	129	90609884
Systemic lupus erythematosus	26.35	17.18	21	18413	361875	90248138
Muscle strain	26.04	17.18	19	18415	9668	90600345
Device related infection	25.85	17.18	29	18405	25757	90584256
Oropharyngeal pain	25.83	17.18	66	18368	115121	90494892
Serum ferritin increased	25.77	17.18	17	18417	7364	90602649
Myelodysplastic syndrome	25.35	17.18	26	18408	20877	90589136
Cytomegalovirus viraemia	25.34	17.18	17	18417	7569	90602444
Organising pneumonia	25.32	17.18	17	18417	7580	90602433
Hypervolaemia	24.89	17.18	32	18402	32725	90577288
C3 glomerulopathy	24.73	17.18	6	18428	171	90609842
Liver injury	24.38	17.18	3	18431	170564	90439449
Ecthyma	24.03	17.18	7	18427	407	90609606
Endothelial dysfunction	23.69	17.18	6	18428	205	90609808
Disseminated cryptococcosis	23.64	17.18	8	18426	761	90609252
Cytopenia	23.54	17.18	23	18411	17426	90592587
Inflammation	23.53	17.18	4	18430	178588	90431425
Reperfusion injury	23.41	17.18	5	18429	79	90609934
Haptoglobin increased	23.41	17.18	5	18429	79	90609934
Blood creatinine abnormal	23.38	17.18	13	18421	4144	90605869
Budd-Chiari syndrome	23.30	17.18	5	18429	81	90609932
Heart transplant rejection	22.91	17.18	8	18426	836	90609177
Disease recurrence	22.88	17.18	33	18401	37620	90572393
Memory impairment	22.75	17.18	6	18428	197238	90412775
Graft thrombosis	22.72	17.18	6	18428	242	90609771
Haptoglobin abnormal	22.50	17.18	3	18431	0	90610013
Small size placenta	22.50	17.18	3	18431	0	90610013
Intentional product use issue	22.49	17.18	8	18426	216884	90393129
Discomfort	22.49	17.18	14	18420	274321	90335692
Pruritus	22.38	17.18	48	18386	541477	90068536
Osteonecrosis	22.12	17.18	27	18407	26214	90583799
SARS-CoV-2 test negative	22.09	17.18	7	18427	541	90609472
Escherichia bacteraemia	21.96	17.18	14	18420	5721	90604292
Small cell lung cancer recurrent	21.95	17.18	4	18430	26	90609987
Meningitis staphylococcal	21.85	17.18	5	18429	110	90609903
Toxicity to various agents	21.84	17.18	16	18418	287830	90322183
Weight increased	21.82	17.18	32	18402	417895	90192118
Confusional state	21.74	17.18	28	18406	386177	90223836
Kidney transplant rejection	21.49	17.18	13	18421	4844	90605169
Drug ineffective for unapproved indication	21.39	17.18	44	18390	66600	90543413
Systemic candida	21.25	17.18	13	18421	4946	90605067
Peritonitis	21.20	17.18	23	18411	19682	90590331
Depression	21.18	17.18	18	18416	300583	90309430
Pneumonia klebsiella	21.18	17.18	11	18423	3061	90606952
Ocular icterus	21.17	17.18	12	18422	3968	90606045
Weight decreased	20.92	17.18	28	18406	379882	90230131
Haematocrit abnormal	20.79	17.18	8	18426	1099	90608914
Uterine atony	20.71	17.18	6	18428	342	90609671
Platelet transfusion	20.70	17.18	8	18426	1112	90608901
Caesarean section	20.55	17.18	22	18412	18555	90591458
Hospitalisation	20.52	17.18	65	18369	128035	90481978
Red blood cell schistocytes present	20.27	17.18	6	18428	369	90609644
Vaccination failure	20.08	17.18	8	18426	1205	90608808
Foetal growth restriction	19.94	17.18	16	18418	9364	90600649
Gastrointestinal disorder	19.82	17.18	14	18420	256673	90353340
Pyelonephritis	19.72	17.18	23	18411	21293	90588720
Decreased appetite	19.49	17.18	29	18405	376511	90233502
Urticaria	19.39	17.18	21	18413	312713	90297300
Blood bilirubin increased	19.32	17.18	33	18401	43437	90566576
Dialysis	19.28	17.18	17	18417	11312	90598701
Haemolytic uraemic syndrome	19.19	17.18	10	18424	2801	90607212
Complications of transplanted kidney	18.97	17.18	10	18424	2868	90607145
Infusion related reaction	18.88	17.18	35	18399	416745	90193268
Normocytic anaemia	18.76	17.18	10	18424	2934	90607079
Injection site pain	18.72	17.18	6	18428	173693	90436320
Mean cell volume increased	18.59	17.18	12	18422	5009	90605004
Hepatic vein thrombosis	18.45	17.18	5	18429	223	90609790
Eyelid ptosis	18.38	17.18	15	18419	8991	90601022
Hypertension	18.28	17.18	157	18277	457375	90152638
Waterhouse-Friderichsen syndrome	17.88	17.18	3	18431	11	90610002
Staphylococcal sepsis	17.84	17.18	15	18419	9368	90600645
Sleep disorder	17.82	17.18	9	18425	198021	90411992
Gait inability	17.78	17.18	4	18430	146452	90463561
Insurance issue	17.77	17.18	16	18418	10942	90599071
Postpartum haemorrhage	17.72	17.18	9	18425	2392	90607621
Mobility decreased	17.68	17.18	15	18419	250719	90359294
Asthma	17.68	17.18	14	18420	242146	90367867
Myasthenia gravis	17.47	17.18	13	18421	6812	90603201
Bursitis	17.23	17.18	3	18431	131651	90478362

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Haemolysis	491.46	18.07	161	12576	9428	42599170
Thrombotic microangiopathy	238.87	18.07	107	12630	14675	42593923
Breakthrough haemolysis	230.98	18.07	41	12696	140	42608458
Haemoglobin decreased	224.65	18.07	235	12502	132236	42476362
Haemoglobinuria	219.65	18.07	49	12688	637	42607961
Blood lactate dehydrogenase increased	219.13	18.07	121	12616	25960	42582638
Extravascular haemolysis	125.86	18.07	25	12712	176	42608422
Reticulocyte count increased	109.82	18.07	29	12708	788	42607810
Haptoglobin decreased	103.12	18.07	27	12710	709	42607889
Chromaturia	96.72	18.07	60	12677	15929	42592669
Myasthenia gravis crisis	94.74	18.07	26	12711	820	42607778
Meningitis meningococcal	91.40	18.07	17	12720	80	42608518
Poor venous access	81.77	18.07	41	12696	7211	42601387
Meningococcal sepsis	74.73	18.07	14	12723	69	42608529
Fatigue	72.66	18.07	289	12448	435352	42173246
Suspected COVID-19	69.12	18.07	23	12714	1407	42607191
Off label use	67.84	18.07	371	12366	637964	41970634
Transfusion	67.52	18.07	41	12696	10473	42598125
Meningococcal bacteraemia	65.86	18.07	10	12727	7	42608591
End stage renal disease	61.58	18.07	46	12691	16512	42592086
Platelet count decreased	59.29	18.07	129	12608	138452	42470146
Total complement activity decreased	53.69	18.07	8	12729	4	42608594
Drug interaction	53.59	18.07	8	12729	266991	42341607
SARS-CoV-2 test positive	52.49	18.07	32	12705	8228	42600370
Meningococcal infection	51.83	18.07	9	12728	26	42608572
Toxicity to various agents	50.55	18.07	5	12732	229131	42379467
Incorrect dose administered	50.00	18.07	70	12667	52904	42555694
Intravascular haemolysis	48.20	18.07	14	12723	544	42608054
Haemoglobin abnormal	47.12	18.07	25	12712	4939	42603659
Complement factor increased	44.96	18.07	7	12730	7	42608591
Vein disorder	43.04	18.07	18	12719	2084	42606514
C3 glomerulopathy	43.00	18.07	10	12727	158	42608440
Polyomavirus viraemia	42.95	18.07	18	12719	2094	42606504
Renal impairment	41.95	18.07	98	12639	110130	42498468
Bone marrow transplant	41.26	18.07	15	12722	1194	42607404
Complement factor C3 decreased	41.10	18.07	8	12729	50	42608548
Staphylococcal mediastinitis	40.96	18.07	8	12729	51	42608547
Infection	39.80	18.07	97	12640	111971	42496627
Headache	38.24	18.07	157	12580	239212	42369386
Aplastic anaemia	36.51	18.07	30	12707	12354	42596244
Posterior reversible encephalopathy syndrome	35.60	18.07	30	12707	12791	42595807
New onset diabetes after transplantation	35.22	18.07	9	12728	214	42608384
Epstein-Barr viraemia	35.13	18.07	16	12721	2273	42606325
Cytomegalovirus oesophagitis	34.74	18.07	11	12726	574	42608024
Jaundice	34.57	18.07	47	12690	34542	42574056
Device related infection	32.47	18.07	35	12702	20244	42588354
Cholelithiasis	31.74	18.07	37	12700	23309	42585289
Condition aggravated	31.15	18.07	157	12580	260597	42348001
Atypical haemolytic uraemic syndrome	31.09	18.07	10	12727	549	42608049
Haematocrit decreased	29.81	18.07	44	12693	34864	42573734
Bone marrow transplant rejection	29.79	18.07	8	12729	232	42608366
Blood product transfusion dependent	28.91	18.07	9	12728	444	42608154
Endoscopy upper gastrointestinal tract abnormal	28.80	18.07	6	12731	55	42608543
Human herpesvirus 6 infection reactivation	28.64	18.07	9	12728	458	42608140
Hand fracture	28.61	18.07	15	12722	2891	42605707
Haptoglobin abnormal	28.46	18.07	4	12733	0	42608598
Candida sepsis	28.33	18.07	12	12725	1433	42607165
Eyelid ptosis	28.15	18.07	20	12717	6641	42601957
Graft versus host disease	27.46	18.07	26	12711	12899	42595699
Foot fracture	27.12	18.07	19	12718	6172	42602426
Quality of life decreased	27.11	18.07	18	12719	5358	42603240
Dyspnoea exertional	26.50	18.07	51	12686	50097	42558501
Polyomavirus-associated nephropathy	26.40	18.07	18	12719	5597	42603001
Arthritis infective	26.32	18.07	16	12721	4090	42604508
Drug effective for unapproved indication	25.94	18.07	19	12718	6614	42601984
Blood creatinine abnormal	24.83	18.07	14	12723	3115	42605483
Encephalitis viral	24.46	18.07	11	12726	1517	42607081
Wound infection	24.14	18.07	20	12717	8326	42600272
Premature baby	23.95	18.07	32	12705	23121	42585477
Viral sepsis	23.88	18.07	6	12731	133	42608465
Multiple organ dysfunction syndrome	23.47	18.07	73	12664	96962	42511636
Haemolytic anaemia	23.14	18.07	23	12714	12104	42596494
Platelet count abnormal	22.83	18.07	14	12723	3635	42604963
Graft loss	22.72	18.07	9	12728	906	42607692
Renal transplant	22.41	18.07	12	12725	2413	42606185
Haemolytic uraemic syndrome	22.17	18.07	12	12725	2467	42606131
Death	22.03	18.07	226	12511	470959	42137639
Renal tubular atrophy	21.79	18.07	10	12727	1445	42607153
Transplant failure	21.51	18.07	14	12723	4030	42604568
Cold agglutinins	21.35	18.07	3	12734	0	42608598
Iron overload	21.28	18.07	10	12727	1525	42607073
Laboratory test abnormal	21.12	18.07	30	12707	22948	42585650
Transplant rejection	20.96	18.07	23	12714	13565	42595033
Disseminated varicella zoster virus infection	20.51	18.07	8	12729	773	42607825
Febrile neutropenia	19.66	18.07	16	12721	185687	42422911
Mean cell volume increased	19.46	18.07	13	12724	3910	42604688
Haematocrit abnormal	19.36	18.07	8	12729	898	42607700
Cytomegalovirus infection reactivation	19.14	18.07	20	12717	11158	42597440
Myelodysplastic syndrome	18.45	18.07	28	12709	22717	42585881
Brain abscess	18.42	18.07	13	12724	4271	42604327
Osteomyelitis chronic	18.29	18.07	6	12731	351	42608247
Influenza	18.12	18.07	50	12687	62125	42546473

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Thrombotic microangiopathy	599.77	16.05	221	20848	28928	110539302
Haemolysis	595.00	16.05	188	20881	15451	110552779
Haemoglobin decreased	325.08	16.05	312	20757	248415	110319815
Blood lactate dehydrogenase increased	284.71	16.05	148	20921	44186	110524044
Off label use	267.56	16.05	753	20316	1499432	109068798
Breakthrough haemolysis	250.48	16.05	44	21025	243	110567987
Extravascular haemolysis	194.04	16.05	38	21031	408	110567822
Meningococcal sepsis	185.67	16.05	32	21037	155	110568075
Meningococcal bacteraemia	167.05	16.05	24	21045	20	110568210
Haptoglobin decreased	166.56	16.05	43	21026	1698	110566532
Haemoglobinuria	141.62	16.05	33	21036	844	110567386
Reticulocyte count increased	140.76	16.05	37	21032	1569	110566661
Meningitis meningococcal	135.06	16.05	25	21044	193	110568037
Incorrect dose administered	120.17	16.05	122	20947	103519	110464711
Platelet count decreased	118.32	16.05	180	20889	230263	110337967
Myasthenia gravis crisis	117.82	16.05	33	21036	1781	110566449
Posterior reversible encephalopathy syndrome	115.56	16.05	75	20994	33786	110534444
Renal impairment	113.87	16.05	159	20910	188286	110379944
Exposure during pregnancy	112.90	16.05	149	20920	167275	110400955
Atypical haemolytic uraemic syndrome	104.53	16.05	29	21040	1511	110566719
Poor venous access	103.06	16.05	62	21007	24460	110543770
End stage renal disease	97.31	16.05	57	21012	21416	110546814
Cytomegalovirus infection	93.92	16.05	80	20989	54364	110513866
Premature delivery	85.73	16.05	60	21009	30572	110537658
Chromaturia	85.66	16.05	59	21010	29301	110538929
Suspected COVID-19	84.94	16.05	30	21039	3463	110564767
Polyomavirus-associated nephropathy	84.87	16.05	38	21031	8163	110560067
Renal transplant failure	84.65	16.05	28	21041	2652	110565578
Multiple organ dysfunction syndrome	79.93	16.05	120	20949	151590	110416640
Polyomavirus viraemia	77.54	16.05	28	21041	3446	110564784
Drug effective for unapproved indication	73.28	16.05	41	21028	14126	110554104
Bronchiolitis obliterans syndrome	70.69	16.05	18	21051	672	110567558
C3 glomerulopathy	70.44	16.05	14	21055	163	110568067
Haemoglobin abnormal	69.17	16.05	34	21035	9004	110559226
Intravascular haemolysis	68.15	16.05	19	21050	1008	110567222
Meningococcal infection	67.34	16.05	14	21055	207	110568023
Cervicitis	62.31	16.05	14	21055	303	110567927
Blood lactate dehydrogenase abnormal	61.84	16.05	16	21053	637	110567593
Pre-eclampsia	61.64	16.05	31	21038	8619	110559611
SARS-CoV-2 test positive	61.45	16.05	39	21030	16896	110551334
Proteinuria	61.36	16.05	55	21014	39963	110528267
Drug interaction	60.71	16.05	11	21058	500172	110068058
Gonorrhoea	60.23	16.05	13	21056	232	110567998
Arteriovenous fistula occlusion	59.60	16.05	15	21054	534	110567696
Inappropriate schedule of product administration	59.05	16.05	124	20945	203513	110364717
Transplant rejection	54.87	16.05	42	21027	24525	110543705
Graft loss	54.79	16.05	17	21052	1311	110566919
Nephrectomy	54.17	16.05	20	21049	2620	110565610
Bacteraemia	52.96	16.05	52	21017	42338	110525892
Complement factor increased	51.74	16.05	8	21061	16	110568214
Haemolytic anaemia	51.70	16.05	38	21031	20882	110547348
Epstein-Barr viraemia	51.67	16.05	21	21048	3558	110564672
Blue toe syndrome	51.53	16.05	14	21055	674	110567556
Dyspnoea exertional	51.52	16.05	80	20989	103980	110464250
Drug ineffective for unapproved indication	50.83	16.05	79	20990	102759	110465471
Total complement activity decreased	50.18	16.05	9	21060	57	110568173
Toxicity to various agents	49.56	16.05	15	21054	480540	110087690
Drug intolerance	49.19	16.05	9	21060	406503	110161727
Condition aggravated	47.08	16.05	269	20800	734567	109833663
Organising pneumonia	44.82	16.05	30	21039	14213	110554017
Staphylococcal mediastinitis	44.42	16.05	8	21061	52	110568178
Vaccination failure	44.22	16.05	17	21052	2489	110565741
Sepsis	44.19	16.05	150	20919	327196	110241034
Graft versus host disease	43.88	16.05	33	21036	18773	110549457
Renal transplant	43.35	16.05	18	21051	3220	110565010
Pneumonia adenoviral	43.20	16.05	12	21057	628	110567602
Iron overload	43.05	16.05	16	21053	2135	110566095
Transfusion	43.04	16.05	37	21032	25435	110542795
Jaundice	40.31	16.05	53	21016	59183	110509047
Blood creatinine increased	39.32	16.05	99	20970	182790	110385440
Death	39.09	16.05	247	20822	698622	109869608
Haemolytic uraemic syndrome	38.88	16.05	19	21050	4966	110563264
Urinary tract infection bacterial	38.10	16.05	22	21047	8045	110560185
Pruritus	37.97	16.05	33	21036	581527	109986703
Arthropathy	37.87	16.05	5	21064	287517	110280713
Cytomegalovirus gastrointestinal infection	37.31	16.05	11	21058	713	110567517
Gonococcal infection	36.76	16.05	7	21062	64	110568166
Confusional state	36.58	16.05	22	21047	468658	110099572
Total complement activity increased	35.48	16.05	5	21064	3	110568227
Rheumatoid arthritis	35.45	16.05	7	21062	299606	110268624
Hypertension	35.45	16.05	191	20878	509893	110058337
Kidney fibrosis	35.04	16.05	17	21052	4375	110563855
Gastroenteritis	34.96	16.05	40	21029	38760	110529470
Pain	34.83	16.05	82	20987	954873	109613357
Wheezing	34.68	16.05	4	21065	255226	110313004
Fungal peritonitis	34.59	16.05	12	21057	1313	110566917
Aplastic anaemia	34.50	16.05	32	21037	24276	110543954
Complement factor C3 decreased	34.46	16.05	9	21060	372	110567858
Rash	33.66	16.05	66	21003	820898	109747332
New onset diabetes after transplantation	33.57	16.05	9	21060	412	110567818
Budd-Chiari syndrome	33.27	16.05	7	21062	110	110568120
Staphylococcal infection	32.16	16.05	52	21017	69892	110498338
Drug hypersensitivity	31.83	16.05	24	21045	454066	110114164
Cytomegalovirus infection reactivation	31.73	16.05	27	21042	18306	110549924
Asthma	31.45	16.05	5	21064	250286	110317944
Herpes simplex	30.99	16.05	25	21044	15739	110552491
Bone marrow transplant rejection	30.86	16.05	8	21061	321	110567909
Endoscopy upper gastrointestinal tract abnormal	30.84	16.05	6	21063	62	110568168
BK virus infection	30.58	16.05	23	21046	13083	110555147
Abdominal discomfort	30.01	16.05	19	21050	393839	110174391
Cytomegalovirus oesophagitis	29.94	16.05	10	21059	976	110567254
Blister	29.83	16.05	4	21065	227372	110340858
Arthritis bacterial	29.81	16.05	21	21048	10799	110557431
COVID-19	29.35	16.05	108	20961	244952	110323278
Pneumocystis jirovecii pneumonia	28.71	16.05	38	21031	42697	110525533
Stomatitis	28.64	16.05	8	21061	270234	110297996
Human herpesvirus 6 infection reactivation	28.61	16.05	10	21059	1119	110567111
Bone marrow transplant	28.36	16.05	11	21058	1649	110566581
Candida sepsis	28.36	16.05	13	21056	2948	110565282
Therapeutic product effect decreased	28.29	16.05	6	21063	244310	110323920
Renal tubular atrophy	28.28	16.05	12	21057	2264	110565966
Product use issue	28.25	16.05	12	21057	311683	110256547
Red blood cell schistocytes present	28.19	16.05	9	21060	762	110567468
Swelling	28.06	16.05	16	21053	351025	110217205
Haematocrit abnormal	27.90	16.05	11	21058	1722	110566508
Device related infection	27.88	16.05	36	21033	39483	110528747
Myelodysplastic syndrome	27.79	16.05	35	21034	37449	110530781
Blood creatinine abnormal	27.64	16.05	16	21053	5876	110562354
Plasmapheresis	27.60	16.05	9	21060	815	110567415
Mean cell volume increased	27.31	16.05	18	21051	8312	110559918
Alopecia	27.24	16.05	18	21051	364735	110203495
Renal pain	26.93	16.05	19	21050	9798	110558432
Fatigue	26.85	16.05	351	20718	1215607	109352623
Vein disorder	26.72	16.05	16	21053	6254	110561976
Platelet count abnormal	26.69	16.05	16	21053	6266	110561964
Joint swelling	26.68	16.05	27	21042	442818	110125412
Cytomegalovirus viraemia	26.41	16.05	24	21045	17740	110550490
Laboratory test abnormal	26.29	16.05	37	21032	44042	110524188
Normocytic anaemia	26.26	16.05	16	21053	6451	110561779
Haematocrit decreased	26.20	16.05	46	21023	66071	110502159
Meningitis	26.12	16.05	20	21049	11682	110556548
Graft ischaemia	26.11	16.05	6	21063	144	110568086
Pulmonary haemorrhage	25.98	16.05	23	21046	16433	110551797
Eyelid ptosis	25.92	16.05	21	21048	13306	110554924
Hypervolaemia	25.84	16.05	39	21030	49421	110518809
Small intestine gangrene	25.67	16.05	5	21064	52	110568178
Renal failure	25.59	16.05	98	20971	226476	110341754
Dry mouth	25.11	16.05	4	21065	199944	110368286
Viral infection	25.11	16.05	40	21029	53099	110515131
Encephalitis viral	25.08	16.05	12	21057	2995	110565235
Adenovirus infection	25.00	16.05	19	21050	10975	110557255
Anaemia	24.96	16.05	184	20885	546902	110021328
Haptoglobin abnormal	24.72	16.05	4	21065	12	110568218
Waterhouse-Friderichsen syndrome	24.72	16.05	4	21065	12	110568218
Depression	24.60	16.05	15	21054	317320	110250910
Memory impairment	24.59	16.05	4	21065	196940	110371290
Hyperparathyroidism tertiary	24.30	16.05	5	21064	70	110568160
Complications of transplanted kidney	24.20	16.05	16	21053	7426	110560804
Neisseria infection	23.96	16.05	6	21063	209	110568021
Pseudomonas infection	23.89	16.05	28	21041	27825	110540405
Abortion spontaneous	23.82	16.05	31	21038	34251	110533979
Septic shock	23.75	16.05	75	20994	157453	110410777
Injury	23.53	16.05	3	21066	177262	110390968
Viral sepsis	23.51	16.05	6	21063	226	110568004
Urticaria	23.45	16.05	16	21053	318841	110249389
Decreased appetite	23.39	16.05	34	21035	475812	110092418
Glomerulonephritis membranoproliferative	23.36	16.05	8	21061	842	110567388
Babesiosis	23.25	16.05	7	21062	488	110567742
Transplant failure	23.03	16.05	14	21055	5621	110562609
Small size placenta	22.70	16.05	3	21066	0	110568230
Anti-complement antibody	22.70	16.05	3	21066	0	110568230
Blood cholesterol increased	22.53	16.05	4	21065	184781	110383449
Symptom recurrence	22.50	16.05	13	21056	4759	110563471
Escherichia urinary tract infection	22.40	16.05	21	21048	16141	110552089
Bronchopulmonary aspergillosis	22.32	16.05	28	21041	29835	110538395
Osteoarthritis	22.16	16.05	4	21065	182619	110385611
Delayed engraftment	22.14	16.05	6	21063	286	110567944
Peritonitis	21.91	16.05	29	21040	32578	110535652
Blood pressure increased	21.61	16.05	102	20967	258271	110309959
Arthritis infective	21.49	16.05	17	21052	10412	110557818
Kidney transplant rejection	21.45	16.05	18	21051	11969	110556261
Cholelithiasis	21.20	16.05	41	21028	63381	110504849
Hepatic enzyme increased	21.17	16.05	18	21051	320874	110247356
Endothelial dysfunction	21.01	16.05	6	21063	347	110567883
Small cell lung cancer recurrent	20.87	16.05	4	21065	38	110568192
Hand fracture	20.62	16.05	15	21054	8107	110560123
Febrile neutropenia	20.62	16.05	18	21051	316749	110251481
Pericarditis	20.56	16.05	8	21061	219106	110349124
Hyponatraemia	20.33	16.05	8	21061	217645	110350585
Disseminated varicella zoster virus infection	20.16	16.05	8	21061	1273	110566957
Microangiopathic haemolytic anaemia	20.09	16.05	9	21060	1934	110566296
Paroxysmal nocturnal haemoglobinuria	19.90	16.05	6	21063	420	110567810
Arthralgia	19.77	16.05	79	20990	779553	109788677
Serum ferritin increased	19.59	16.05	17	21052	11830	110556400
Bacterial sepsis	19.37	16.05	16	21053	10410	110557820
Nephrotic syndrome	19.23	16.05	18	21051	13813	110554417
Reperfusion injury	19.04	16.05	5	21064	211	110568019
Cytopenia	19.04	16.05	26	21043	30090	110538140
Blood product transfusion dependent	19.01	16.05	6	21063	489	110567741
Paraesthesia	18.87	16.05	15	21054	276506	110291724
Pneumonia bacterial	18.64	16.05	24	21045	26237	110541993
Thrombosis	18.50	16.05	54	21015	108608	110459622
Meningitis staphylococcal	18.50	16.05	5	21064	236	110567994
Hypertensive crisis	18.45	16.05	23	21046	24349	110543881
Haptoglobin increased	18.38	16.05	5	21064	242	110567988
Muscle strain	18.37	16.05	16	21053	11186	110557044
Brain abscess	18.32	16.05	13	21056	6761	110561469
Inflammation	18.22	16.05	7	21062	193231	110374999
Osteonecrosis	18.19	16.05	27	21042	33714	110534516
Ecthyma	18.16	16.05	7	21062	1032	110567198
Gastrointestinal disorder	17.97	16.05	12	21057	241940	110326290
Uterine atony	17.90	16.05	5	21064	267	110567963
Intestinal perforation	17.87	16.05	21	21048	20923	110547307
Product dose omission issue	17.85	16.05	21	21048	321761	110246469
Endocarditis	17.82	16.05	17	21052	13354	110554876
Dysphagia	17.80	16.05	67	21002	153533	110414697
Infection	17.75	16.05	124	20945	362076	110206154
Staphylococcal sepsis	17.45	16.05	19	21050	17435	110550795
Disseminated cryptococcosis	17.41	16.05	9	21060	2648	110565582
Oropharyngeal pain	17.36	16.05	61	21008	135215	110433015
Caesarean section	17.35	16.05	17	21052	13800	110554430
Malignant atrophic papulosis	17.33	16.05	3	21066	15	110568215
Blood bilirubin increased	17.24	16.05	42	21027	75930	110492300
Diarrhoea	17.18	16.05	137	20932	1139368	109428862
Systemic lupus erythematosus	17.10	16.05	14	21055	254324	110313906
Hepatic vein thrombosis	17.08	16.05	5	21064	316	110567914
Haematuria	16.86	16.05	44	21025	82961	110485269
Overdose	16.83	16.05	12	21057	233782	110334448
Urinary tract infection fungal	16.67	16.05	7	21062	1288	110566942
Heart transplant rejection	16.66	16.05	8	21061	2013	110566217
Respiratory failure	16.56	16.05	83	20986	215249	110352981
Gait inability	16.52	16.05	3	21066	136373	110431857
Complement factor C4 decreased	16.47	16.05	5	21064	358	110567872
Purpura fulminans	16.45	16.05	5	21064	360	110567870
Hypersplenism	16.45	16.05	6	21063	760	110567470
Reticulocyte count abnormal	16.24	16.05	4	21065	130	110568100
Osteomyelitis chronic	16.21	16.05	6	21063	791	110567439
Foot fracture	16.06	16.05	22	21047	25524	110542706

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L04AJ01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Complement inhibitors
FDA EPC	N0000175575	Complement Inhibitor
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
MeSH PA	D051056	Complement Inactivating Agents
FDA MoA	N0000175974	Complement Inhibitors
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:75835	anti-anaemic agent

Related Drugs by ATC class:

L04AJ Complement inhibitors 10 drugs

avacopancrovalimab-akkzdanicopaniptacopanpegcetacoplanpozelimabravulizumabsutimlimabvilobelimabzilucoplan

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Paroxysmal nocturnal hemoglobinuria	indication	1963002	DOID:0060284
Neuromyelitis optica	indication	25044007	DOID:8869
Refractory generalized myasthenia gravis	indication	230686005
Congenital hemolytic uremic syndrome	indication	444976001
Atypical hemolytic uremic syndrome	indication	789660001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Complement C5	Secreted	P01031	CO5_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D03940	KEGG_DRUG
4026032	VUID
N0000179786	NUI
2648435-91-8	SECONDARY_CAS_RN
4026032	VANDF
CHEBI:749604	CHEBI
CHEMBL1201828	ChEMBL_ID
C481642	MESH_SUPPLEMENTAL_RECORD_UI
6884	IUPHAR_LIGAND_ID
DB01257	DRUGBANK_ID
591781	RXNORM
108542	MMSL
23533	MMSL
d06673	MMSL
012087	NDDF
426801002	SNOMEDCT_US
427429004	SNOMEDCT_US
C1541483	UMLSCUI
8231	INN_ID
A3ULP0F556	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
SOLIRIS	HUMAN PRESCRIPTION DRUG LABEL	1	25682-001	INJECTION, SOLUTION, CONCENTRATE	300 mg	INTRAVENOUS	BLA	30 sections
EPYSQLI	HUMAN PRESCRIPTION DRUG LABEL	1	51759-208	INJECTION, SOLUTION	300 mg	INTRAVENOUS	BLA	29 sections
BKEMV	HUMAN PRESCRIPTION DRUG LABEL	1	55513-180	INJECTION, SOLUTION, CONCENTRATE	300 mg	INTRAVENOUS	BLA	31 sections
BKEMV	HUMAN PRESCRIPTION DRUG LABEL	1	55513-180	INJECTION, SOLUTION, CONCENTRATE	300 mg	INTRAVENOUS	BLA	31 sections