raxibacumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	4961	565451-13-0

Description:

Molecule

Description

Synonyms:

raxibacumab
ABthrax

is a human IgG1lambda monoclonal antibody directed against protective antigen, a component of the anthrax toxin.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 15, 2014	EMA
Dec. 14, 2012	FDA	HUMAN GENOME SCIENCES INC.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J06BC02	ANTIINFECTIVES FOR SYSTEMIC USE IMMUNE SERA AND IMMUNOGLOBULINS IMMUNOGLOBULINS Antibacterial monoclonal antibodies
FDA MoA	N0000192702	Anthrax Protective Antigen-directed Antibody Interactions
FDA EPC	N0000192703	Anthrax Protective Antigen-directed Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Inhalational anthrax	indication	11389007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Protective antigen	Secreted		PAG_BACAN	ANTIBODY BINDING	Kd	8.56		DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D05706	KEGG_DRUG
4040660	VANDF
CHEMBL2108638	ChEMBL_ID
C542124	MESH_SUPPLEMENTAL_RECORD_UI
DB08902	DRUGBANK_ID
1366567	RXNORM
018790	NDDF
725529008	SNOMEDCT_US
C2717174	UMLSCUI
8580	INN_ID
794PGL549S	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Raxibacumab	HUMAN PRESCRIPTION DRUG LABEL	1	49401-103	INJECTION	50 mg	INTRAVENOUS	BLA	27 sections
Raxibacumab	HUMAN PRESCRIPTION DRUG LABEL	1	49401-104	INJECTION	50 mg	INTRAVENOUS	BLA	27 sections
Raxibacumab	HUMAN PRESCRIPTION DRUG LABEL	1	71655-103	INJECTION	50 mg	INTRAVENOUS	BLA	28 sections