carbetocin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
oxytocin derivatives 495 37025-55-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pabal
  • carbetocin
  • depotocin
  • duratocin
carbetocin selectively binds to oxytocin receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the tone of the uterus musculature
  • Molecular weight: 988.17
  • Formula: C45H69N11O12S
  • CLOGP: 0.82
  • LIPINSKI: 3
  • HAC: 23
  • HDO: 10
  • TPSA: 362.51
  • ALOGS: -4.57
  • ROTB: 18

Drug dosage:

DoseUnitRoute
0.10 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 5, 2007 UK Medicines and Healthcare Products Regulatory Agency (MHRA) Ferring Pharmaceuticals Ltd

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01BB03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
POSTERIOR PITUITARY LOBE HORMONES
Oxytocin and analogues
MeSH PA D003692 Delayed-Action Preparations
MeSH PA D010120 Oxytocics
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:36063 oxytocic agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atony of uterus indication 9293002
Prader-Willi syndrome indication 89392001 DOID:11983




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.59 acidic
pKa2 13.2 acidic
pKa3 13.33 acidic
pKa4 13.57 acidic
pKa5 13.94 acidic
pKa6 13.98 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Oxytocin receptor GPCR AGONIST Ki 8.15 SCIENTIFIC LITERATURE DRUG LABEL
Vasopressin V1a receptor GPCR EC50 7.39 CHEMBL
Vasopressin V2 receptor GPCR Ki 5.23 SCIENTIFIC LITERATURE
Oxytocin receptor GPCR AGONIST EC50 7.21 IUPHAR

External reference:

IDSource
D07229 KEGG_DRUG
C0054670 UMLSCUI
CHEBI:59204 CHEBI
CHEMBL3301668 ChEMBL_ID
DB01282 DRUGBANK_ID
C020731 MESH_SUPPLEMENTAL_RECORD_UI
11169 IUPHAR_LIGAND_ID
5014 INN_ID
88TWF8015Y UNII
16681432 PUBCHEM_CID
006738 NDDF
423594000 SNOMEDCT_US
425003007 SNOMEDCT_US

Pharmaceutical products:

None