Stem definition | Drug id | CAS RN |
---|---|---|
humanized origin | 4957 | 380610-27-5 |
Molecule | Description |
---|---|
Synonyms:
|
a humanized HER-2 monoclonal antibody; prevents ERBB2 receptor protein from binding (dimerizing) to other receptors in the HER family
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
June 8, 2012 | FDA | GENENTECH | |
March 4, 2013 | EMA | ||
June 28, 2013 | PMDA | Chugai Pharmaceutical |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Diarrhoea | 1178.64 | 18.28 | 1839 | 38149 | 586637 | 49978499 |
Ejection fraction decreased | 860.85 | 18.28 | 376 | 39612 | 18144 | 50546992 |
Myelosuppression | 629.84 | 18.28 | 275 | 39713 | 13242 | 50551894 |
Neuropathy peripheral | 508.23 | 18.28 | 495 | 39493 | 96262 | 50468874 |
Febrile neutropenia | 433.02 | 18.28 | 456 | 39532 | 97211 | 50467925 |
Polyneuropathy | 420.69 | 18.28 | 201 | 39787 | 11930 | 50553206 |
Metastases to central nervous system | 406.73 | 18.28 | 192 | 39796 | 11090 | 50554046 |
Disease progression | 354.44 | 18.28 | 407 | 39581 | 95459 | 50469677 |
Mucosal inflammation | 300.52 | 18.28 | 251 | 39737 | 39891 | 50525245 |
Cardiotoxicity | 292.00 | 18.28 | 132 | 39856 | 6895 | 50558241 |
Neutropenia | 284.35 | 18.28 | 457 | 39531 | 147508 | 50417628 |
Drug ineffective | 212.67 | 18.28 | 202 | 39786 | 819131 | 49746005 |
Chills | 202.67 | 18.28 | 311 | 39677 | 96376 | 50468760 |
Interstitial lung disease | 188.29 | 18.28 | 221 | 39767 | 52955 | 50512181 |
Palmar-plantar erythrodysaesthesia syndrome | 185.16 | 18.28 | 142 | 39846 | 19956 | 50545180 |
Peripheral sensory neuropathy | 174.62 | 18.28 | 91 | 39897 | 6500 | 50558636 |
Left ventricular dysfunction | 159.77 | 18.28 | 101 | 39887 | 10405 | 50554731 |
Neutropenic sepsis | 150.53 | 18.28 | 109 | 39879 | 14038 | 50551098 |
Rheumatoid arthritis | 145.43 | 18.28 | 3 | 39985 | 202547 | 50362589 |
Skin toxicity | 124.04 | 18.28 | 61 | 39927 | 3852 | 50561284 |
Joint swelling | 122.17 | 18.28 | 23 | 39965 | 245263 | 50319873 |
Pneumonitis | 122.04 | 18.28 | 133 | 39855 | 29377 | 50535759 |
Fall | 120.69 | 18.28 | 57 | 39931 | 334875 | 50230261 |
Epistaxis | 120.47 | 18.28 | 196 | 39792 | 63758 | 50501378 |
Product dose omission issue | 120.39 | 18.28 | 6 | 39982 | 183832 | 50381304 |
Stomatitis | 118.49 | 18.28 | 253 | 39735 | 101091 | 50464045 |
Drug hypersensitivity | 113.95 | 18.28 | 29 | 39959 | 250981 | 50314155 |
Metastases to lung | 112.91 | 18.28 | 83 | 39905 | 10937 | 50554199 |
Cardiac dysfunction | 110.86 | 18.28 | 44 | 39944 | 1657 | 50563479 |
Arthropathy | 110.78 | 18.28 | 3 | 39985 | 157903 | 50407233 |
Vascular device infection | 106.13 | 18.28 | 57 | 39931 | 4327 | 50560809 |
Off label use | 98.58 | 18.28 | 676 | 39312 | 473750 | 50091386 |
Abdominal discomfort | 97.28 | 18.28 | 31 | 39957 | 231610 | 50333526 |
Metastases to bone | 95.95 | 18.28 | 93 | 39895 | 17902 | 50547234 |
Nail toxicity | 93.16 | 18.28 | 26 | 39962 | 314 | 50564822 |
Onycholysis | 92.34 | 18.28 | 36 | 39952 | 1292 | 50563844 |
Hypokalaemia | 89.69 | 18.28 | 208 | 39780 | 87784 | 50477352 |
Breast cancer recurrent | 87.97 | 18.28 | 48 | 39940 | 3760 | 50561376 |
Therapeutic product effect decreased | 87.30 | 18.28 | 5 | 39983 | 136045 | 50429091 |
Pleural effusion | 86.84 | 18.28 | 196 | 39792 | 81258 | 50483878 |
Metastases to liver | 85.54 | 18.28 | 92 | 39896 | 20012 | 50545124 |
Dysgeusia | 85.41 | 18.28 | 128 | 39860 | 38788 | 50526348 |
Drug interaction | 83.30 | 18.28 | 27 | 39961 | 199594 | 50365542 |
Systemic lupus erythematosus | 82.20 | 18.28 | 8 | 39980 | 140614 | 50424522 |
Decreased appetite | 81.96 | 18.28 | 345 | 39643 | 200578 | 50364558 |
Exposure during pregnancy | 79.03 | 18.28 | 4 | 39984 | 121011 | 50444125 |
Nail dystrophy | 78.41 | 18.28 | 28 | 39960 | 783 | 50564353 |
Condition aggravated | 76.80 | 18.28 | 73 | 39915 | 296985 | 50268151 |
Metastasis | 76.54 | 18.28 | 46 | 39942 | 4329 | 50560807 |
Bone pain | 76.02 | 18.28 | 135 | 39853 | 47094 | 50518042 |
Cardiac failure | 75.57 | 18.28 | 178 | 39810 | 75862 | 50489274 |
Cardiomyopathy | 74.67 | 18.28 | 76 | 39912 | 15510 | 50549626 |
Metastases to lymph nodes | 74.44 | 18.28 | 54 | 39934 | 6970 | 50558166 |
Vomiting | 74.42 | 18.28 | 619 | 39369 | 460139 | 50104997 |
Pain | 74.20 | 18.28 | 224 | 39764 | 578679 | 49986457 |
Nail discolouration | 72.54 | 18.28 | 36 | 39952 | 2318 | 50562818 |
Musculoskeletal stiffness | 68.45 | 18.28 | 10 | 39978 | 128471 | 50436665 |
Lacrimation increased | 67.49 | 18.28 | 75 | 39913 | 16917 | 50548219 |
Nail disorder | 67.04 | 18.28 | 58 | 39930 | 9650 | 50555486 |
Neoplasm progression | 66.99 | 18.28 | 98 | 39890 | 29059 | 50536077 |
Sinusitis | 66.14 | 18.28 | 26 | 39962 | 170532 | 50394604 |
Lymphoedema | 66.05 | 18.28 | 56 | 39932 | 9066 | 50556070 |
Device related infection | 63.29 | 18.28 | 80 | 39908 | 20655 | 50544481 |
Injection site pain | 63.11 | 18.28 | 7 | 39981 | 111017 | 50454119 |
Radiation skin injury | 62.15 | 18.28 | 24 | 39964 | 839 | 50564297 |
Erysipelas | 61.52 | 18.28 | 47 | 39941 | 6561 | 50558575 |
Drug intolerance | 58.77 | 18.28 | 52 | 39936 | 219052 | 50346084 |
Cellulitis | 58.01 | 18.28 | 154 | 39834 | 70644 | 50494492 |
Neurotoxicity | 56.72 | 18.28 | 64 | 39924 | 14676 | 50550460 |
Hepatic enzyme increased | 56.54 | 18.28 | 19 | 39969 | 137361 | 50427775 |
Tonsillar disorder | 54.59 | 18.28 | 23 | 39965 | 1011 | 50564125 |
Discomfort | 52.14 | 18.28 | 11 | 39977 | 108369 | 50456767 |
Breast pain | 51.94 | 18.28 | 45 | 39943 | 7499 | 50557637 |
Treatment failure | 51.70 | 18.28 | 22 | 39966 | 137615 | 50427521 |
Fatigue | 51.29 | 18.28 | 813 | 39175 | 706788 | 49858348 |
Tumour pain | 50.75 | 18.28 | 23 | 39965 | 1207 | 50563929 |
Colitis | 50.63 | 18.28 | 101 | 39887 | 38428 | 50526708 |
Constipation | 50.50 | 18.28 | 284 | 39704 | 185424 | 50379712 |
Nausea | 50.19 | 18.28 | 808 | 39180 | 704590 | 49860546 |
Confusional state | 50.00 | 18.28 | 44 | 39944 | 185884 | 50379252 |
Excessive eye blinking | 49.80 | 18.28 | 21 | 39967 | 925 | 50564211 |
Cystitis noninfective | 49.39 | 18.28 | 20 | 39968 | 794 | 50564342 |
Pyrexia | 48.62 | 18.28 | 486 | 39502 | 379717 | 50185419 |
Dyspnoea | 47.79 | 18.28 | 650 | 39338 | 546958 | 50018178 |
Anaemia | 47.67 | 18.28 | 352 | 39636 | 252104 | 50313032 |
Somnolence | 47.62 | 18.28 | 32 | 39956 | 154953 | 50410183 |
Dehydration | 47.47 | 18.28 | 242 | 39746 | 152207 | 50412929 |
Swelling | 46.64 | 18.28 | 54 | 39934 | 200818 | 50364318 |
Paronychia | 45.90 | 18.28 | 34 | 39954 | 4530 | 50560606 |
Hypertransaminasaemia | 45.81 | 18.28 | 31 | 39957 | 3580 | 50561556 |
Hyperpyrexia | 45.57 | 18.28 | 29 | 39959 | 3020 | 50562116 |
Metastases to skin | 45.15 | 18.28 | 22 | 39966 | 1361 | 50563775 |
Mastitis | 44.51 | 18.28 | 26 | 39962 | 2321 | 50562815 |
Hyperfibrinogenaemia | 44.18 | 18.28 | 9 | 39979 | 22 | 50565114 |
Weight increased | 44.00 | 18.28 | 57 | 39931 | 201834 | 50363302 |
Mastectomy | 43.89 | 18.28 | 22 | 39966 | 1447 | 50563689 |
Arthritis | 43.39 | 18.28 | 8 | 39980 | 86713 | 50478423 |
Nail infection | 43.09 | 18.28 | 24 | 39964 | 1957 | 50563179 |
Alopecia | 42.52 | 18.28 | 335 | 39653 | 244712 | 50320424 |
Red cell distribution width increased | 41.48 | 18.28 | 42 | 39946 | 8517 | 50556619 |
Systolic dysfunction | 40.93 | 18.28 | 21 | 39967 | 1451 | 50563685 |
Gastrointestinal toxicity | 40.78 | 18.28 | 32 | 39956 | 4645 | 50560491 |
Haematotoxicity | 40.58 | 18.28 | 40 | 39948 | 7855 | 50557281 |
Pseudocirrhosis | 40.02 | 18.28 | 16 | 39972 | 614 | 50564522 |
Breast cancer metastatic | 39.88 | 18.28 | 45 | 39943 | 10319 | 50554817 |
Gait disturbance | 39.72 | 18.28 | 36 | 39952 | 149969 | 50415167 |
Onychalgia | 39.70 | 18.28 | 17 | 39971 | 778 | 50564358 |
Inappropriate schedule of product administration | 39.65 | 18.28 | 5 | 39983 | 71826 | 50493310 |
Onychomadesis | 39.33 | 18.28 | 28 | 39960 | 3508 | 50561628 |
Dry skin | 38.50 | 18.28 | 97 | 39891 | 43094 | 50522042 |
Aortitis | 38.19 | 18.28 | 17 | 39971 | 855 | 50564281 |
Wound | 38.01 | 18.28 | 18 | 39970 | 105776 | 50459360 |
Onychoclasis | 37.82 | 18.28 | 32 | 39956 | 5164 | 50559972 |
Pericarditis | 37.81 | 18.28 | 8 | 39980 | 78681 | 50486455 |
Chest discomfort | 37.55 | 18.28 | 159 | 39829 | 92563 | 50472573 |
Blood creatine increased | 37.44 | 18.28 | 31 | 39957 | 4856 | 50560280 |
Osteoarthritis | 37.33 | 18.28 | 5 | 39983 | 68601 | 50496535 |
Nasal disorder | 37.13 | 18.28 | 23 | 39965 | 2285 | 50562851 |
Product use issue | 37.10 | 18.28 | 38 | 39950 | 149437 | 50415699 |
Maternal exposure during pregnancy | 37.03 | 18.28 | 43 | 39945 | 159735 | 50405401 |
Vessel puncture site bruise | 36.94 | 18.28 | 13 | 39975 | 348 | 50564788 |
Dyschezia | 36.92 | 18.28 | 21 | 39967 | 1783 | 50563353 |
Glossodynia | 36.67 | 18.28 | 23 | 39965 | 115546 | 50449590 |
Drug abuse | 36.04 | 18.28 | 3 | 39985 | 59843 | 50505293 |
Toxicity to various agents | 35.92 | 18.28 | 71 | 39917 | 212428 | 50352708 |
Meibomian gland dysfunction | 35.81 | 18.28 | 10 | 39978 | 121 | 50565015 |
Product use in unapproved indication | 35.45 | 18.28 | 24 | 39964 | 115795 | 50449341 |
Biliary sepsis | 35.40 | 18.28 | 16 | 39972 | 834 | 50564302 |
Therapeutic product effect incomplete | 35.37 | 18.28 | 14 | 39974 | 91501 | 50473635 |
Madarosis | 34.94 | 18.28 | 23 | 39965 | 2537 | 50562599 |
Mobility decreased | 34.78 | 18.28 | 10 | 39978 | 79938 | 50485198 |
Hot flush | 34.08 | 18.28 | 94 | 39894 | 44075 | 50521061 |
Asthma | 33.98 | 18.28 | 14 | 39974 | 89323 | 50475813 |
Acute interstitial pneumonitis | 33.36 | 18.28 | 14 | 39974 | 609 | 50564527 |
Suicidal ideation | 32.75 | 18.28 | 3 | 39985 | 55382 | 50509754 |
Neutrophil count decreased | 32.63 | 18.28 | 95 | 39893 | 45931 | 50519205 |
Breast inflammation | 32.00 | 18.28 | 9 | 39979 | 112 | 50565024 |
Impaired healing | 31.73 | 18.28 | 8 | 39980 | 69778 | 50495358 |
Malignant neoplasm progression | 31.71 | 18.28 | 122 | 39866 | 68002 | 50497134 |
Breast neoplasm | 31.58 | 18.28 | 17 | 39971 | 1296 | 50563840 |
Vascular fragility | 31.22 | 18.28 | 9 | 39979 | 123 | 50565013 |
Feeling abnormal | 31.03 | 18.28 | 32 | 39956 | 125460 | 50439676 |
Folate deficiency | 30.23 | 18.28 | 19 | 39969 | 1936 | 50563200 |
Bradycardia | 30.04 | 18.28 | 7 | 39981 | 64419 | 50500717 |
General physical health deterioration | 29.38 | 18.28 | 203 | 39785 | 142231 | 50422905 |
Post-traumatic pain | 29.03 | 18.28 | 11 | 39977 | 365 | 50564771 |
Paraesthesia | 28.84 | 18.28 | 178 | 39810 | 120065 | 50445071 |
Hypothalamo-pituitary disorder | 28.83 | 18.28 | 13 | 39975 | 674 | 50564462 |
Lower respiratory tract infection | 28.82 | 18.28 | 150 | 39838 | 95051 | 50470085 |
Radiation pneumonitis | 28.56 | 18.28 | 16 | 39972 | 1319 | 50563817 |
Alopecia areata | 28.20 | 18.28 | 16 | 39972 | 1352 | 50563784 |
Depression | 28.18 | 18.28 | 55 | 39933 | 165368 | 50399768 |
Flushing | 27.97 | 18.28 | 116 | 39872 | 66899 | 50498237 |
Infusion related reaction | 27.84 | 18.28 | 229 | 39759 | 169328 | 50395808 |
Enterocolitis | 27.84 | 18.28 | 30 | 39958 | 6537 | 50558599 |
Nail bed bleeding | 27.82 | 18.28 | 10 | 39978 | 285 | 50564851 |
Blood magnesium decreased | 27.81 | 18.28 | 39 | 39949 | 11121 | 50554015 |
Contusion | 27.29 | 18.28 | 29 | 39959 | 112154 | 50452982 |
Arthralgia | 27.29 | 18.28 | 219 | 39769 | 438483 | 50126653 |
Enterocolitis infectious | 27.05 | 18.28 | 16 | 39972 | 1462 | 50563674 |
Mucosal dryness | 26.56 | 18.28 | 19 | 39969 | 2398 | 50562738 |
Radiation necrosis | 26.35 | 18.28 | 10 | 39978 | 333 | 50564803 |
Axillary pain | 26.02 | 18.28 | 16 | 39972 | 1568 | 50563568 |
Pituitary tumour | 25.98 | 18.28 | 13 | 39975 | 852 | 50564284 |
Osteitis condensans | 25.97 | 18.28 | 6 | 39982 | 31 | 50565105 |
Sarcoid-like reaction | 25.95 | 18.28 | 5 | 39983 | 8 | 50565128 |
Rectal haemorrhage | 25.82 | 18.28 | 78 | 39910 | 38480 | 50526656 |
Bone marrow failure | 25.63 | 18.28 | 63 | 39925 | 27561 | 50537575 |
Depressed level of consciousness | 25.54 | 18.28 | 5 | 39983 | 51948 | 50513188 |
Dermatitis acneiform | 25.53 | 18.28 | 23 | 39965 | 4034 | 50561102 |
Rash | 25.50 | 18.28 | 486 | 39502 | 436985 | 50128151 |
Metastases to soft tissue | 25.31 | 18.28 | 8 | 39980 | 152 | 50564984 |
White blood cell count abnormal | 25.10 | 18.28 | 26 | 39962 | 5414 | 50559722 |
Vaginal prolapse | 25.06 | 18.28 | 10 | 39978 | 382 | 50564754 |
Catheter site pain | 25.01 | 18.28 | 22 | 39966 | 3740 | 50561396 |
Skin infection | 24.94 | 18.28 | 39 | 39949 | 12252 | 50552884 |
Hair colour changes | 24.53 | 18.28 | 19 | 39969 | 2705 | 50562431 |
Rhinorrhoea | 24.51 | 18.28 | 93 | 39895 | 51490 | 50513646 |
Adverse event | 24.26 | 18.28 | 3 | 39985 | 43760 | 50521376 |
Autonomic neuropathy | 24.04 | 18.28 | 13 | 39975 | 1000 | 50564136 |
Pulmonary embolism | 24.03 | 18.28 | 150 | 39838 | 101554 | 50463582 |
Hyperchlorhydria | 24.00 | 18.28 | 15 | 39973 | 1513 | 50563623 |
Osteonecrosis of jaw | 23.88 | 18.28 | 68 | 39920 | 32458 | 50532678 |
Keratitis | 23.85 | 18.28 | 18 | 39970 | 2467 | 50562669 |
Pneumonitis chemical | 23.83 | 18.28 | 8 | 39980 | 185 | 50564951 |
Injury | 23.45 | 18.28 | 5 | 39983 | 48920 | 50516216 |
Mucosal disorder | 23.40 | 18.28 | 16 | 39972 | 1879 | 50563257 |
Duodenal ulcer perforation | 23.26 | 18.28 | 4 | 39984 | 45607 | 50519529 |
Paralysis recurrent laryngeal nerve | 23.19 | 18.28 | 6 | 39982 | 53 | 50565083 |
Hypoaesthesia | 23.15 | 18.28 | 176 | 39812 | 127081 | 50438055 |
Incorrect dose administered | 23.10 | 18.28 | 5 | 39983 | 48409 | 50516727 |
Mean platelet volume decreased | 23.01 | 18.28 | 15 | 39973 | 1627 | 50563509 |
Overdose | 22.92 | 18.28 | 27 | 39961 | 99700 | 50465436 |
Secondary cerebellar degeneration | 22.90 | 18.28 | 6 | 39982 | 56 | 50565080 |
Odynophagia | 22.84 | 18.28 | 27 | 39961 | 6505 | 50558631 |
Hypoglycaemia | 22.76 | 18.28 | 7 | 39981 | 53574 | 50511562 |
Therapy partial responder | 22.65 | 18.28 | 27 | 39961 | 6564 | 50558572 |
Anxiety | 22.42 | 18.28 | 69 | 39919 | 177537 | 50387599 |
Dysuria | 22.32 | 18.28 | 61 | 39927 | 28443 | 50536693 |
Tongue coated | 22.10 | 18.28 | 13 | 39975 | 1176 | 50563960 |
Hallucination | 21.89 | 18.28 | 5 | 39983 | 46652 | 50518484 |
Perforation | 21.85 | 18.28 | 12 | 39976 | 952 | 50564184 |
Wheezing | 21.61 | 18.28 | 11 | 39977 | 62036 | 50503100 |
Blood glucose increased | 21.53 | 18.28 | 15 | 39973 | 71309 | 50493827 |
Gastritis | 21.41 | 18.28 | 66 | 39922 | 32917 | 50532219 |
Cardio-respiratory arrest | 21.22 | 18.28 | 8 | 39980 | 53884 | 50511252 |
Nodular regenerative hyperplasia | 21.15 | 18.28 | 8 | 39980 | 264 | 50564872 |
Nasal congestion | 21.14 | 18.28 | 7 | 39981 | 51113 | 50514023 |
Hyperkalaemia | 20.94 | 18.28 | 6 | 39982 | 48083 | 50517053 |
Rhabdomyolysis | 20.86 | 18.28 | 3 | 39985 | 39024 | 50526112 |
Mitral valve incompetence | 20.82 | 18.28 | 44 | 39944 | 17427 | 50547709 |
Myocardial infarction | 20.57 | 18.28 | 24 | 39964 | 89003 | 50476133 |
Osteosclerosis | 20.54 | 18.28 | 19 | 39969 | 3448 | 50561688 |
Retracted nipple | 20.54 | 18.28 | 4 | 39984 | 7 | 50565129 |
Delirium | 20.26 | 18.28 | 3 | 39985 | 38189 | 50526947 |
Breast disorder | 20.19 | 18.28 | 15 | 39973 | 2007 | 50563129 |
Dandy-Walker syndrome | 20.18 | 18.28 | 6 | 39982 | 92 | 50565044 |
Subcutaneous abscess | 20.16 | 18.28 | 22 | 39966 | 4860 | 50560276 |
Ventricular hypokinesia | 20.15 | 18.28 | 20 | 39968 | 3960 | 50561176 |
Abdominal rigidity | 20.13 | 18.28 | 14 | 39974 | 1690 | 50563446 |
Electrocardiogram QT prolonged | 19.94 | 18.28 | 8 | 39980 | 51878 | 50513258 |
Coma | 19.93 | 18.28 | 10 | 39978 | 56869 | 50508267 |
Blister | 19.76 | 18.28 | 23 | 39965 | 85395 | 50479741 |
Metastases to spine | 19.72 | 18.28 | 17 | 39971 | 2814 | 50562322 |
Hair texture abnormal | 19.68 | 18.28 | 19 | 39969 | 3637 | 50561499 |
Appendiceal abscess | 19.59 | 18.28 | 7 | 39981 | 196 | 50564940 |
Vagus nerve disorder | 19.55 | 18.28 | 6 | 39982 | 103 | 50565033 |
Rash follicular | 19.45 | 18.28 | 5 | 39983 | 43 | 50565093 |
Axillary vein thrombosis | 19.42 | 18.28 | 8 | 39980 | 332 | 50564804 |
Agitation | 19.29 | 18.28 | 9 | 39979 | 53375 | 50511761 |
Pericardial effusion | 19.28 | 18.28 | 54 | 39934 | 25535 | 50539601 |
Osteolysis | 19.13 | 18.28 | 16 | 39972 | 2541 | 50562595 |
Gastrointestinal haemorrhage | 18.92 | 18.28 | 18 | 39970 | 73303 | 50491833 |
Palmar erythema | 18.84 | 18.28 | 13 | 39975 | 1550 | 50563586 |
Pleural disorder | 18.74 | 18.28 | 9 | 39979 | 539 | 50564597 |
Tachycardia | 18.71 | 18.28 | 139 | 39849 | 99624 | 50465512 |
Opsoclonus myoclonus | 18.55 | 18.28 | 6 | 39982 | 123 | 50565013 |
Oxygen saturation decreased | 18.55 | 18.28 | 110 | 39878 | 73138 | 50491998 |
Borrelia infection | 18.37 | 18.28 | 6 | 39982 | 127 | 50565009 |
Corneal disorder | 18.37 | 18.28 | 13 | 39975 | 1613 | 50563523 |
Myalgia | 18.34 | 18.28 | 164 | 39824 | 124155 | 50440981 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Carbohydrate antigen 15-3 increased | 65.93 | 52.32 | 9 | 822 | 69 | 29573627 |
Tidal volume decreased | 63.00 | 52.32 | 8 | 823 | 32 | 29573664 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Diarrhoea | 884.13 | 18.70 | 1467 | 33321 | 721237 | 63742707 |
Ejection fraction decreased | 593.99 | 18.70 | 296 | 34492 | 28411 | 64435533 |
Myelosuppression | 496.73 | 18.70 | 247 | 34541 | 23583 | 64440361 |
Neuropathy peripheral | 413.06 | 18.70 | 406 | 34382 | 117119 | 64346825 |
Polyneuropathy | 327.47 | 18.70 | 176 | 34612 | 19718 | 64444226 |
Metastases to central nervous system | 301.10 | 18.70 | 148 | 34640 | 13764 | 64450180 |
Febrile neutropenia | 274.64 | 18.70 | 416 | 34372 | 187241 | 64276703 |
Mucosal inflammation | 211.75 | 18.70 | 212 | 34576 | 62372 | 64401572 |
Disease progression | 206.98 | 18.70 | 314 | 34474 | 141366 | 64322578 |
Cardiotoxicity | 192.07 | 18.70 | 99 | 34689 | 10175 | 64453769 |
Neutropenia | 177.68 | 18.70 | 396 | 34392 | 239228 | 64224716 |
Drug ineffective | 175.35 | 18.70 | 120 | 34668 | 840127 | 63623817 |
Chills | 153.94 | 18.70 | 270 | 34518 | 136994 | 64326950 |
Peripheral sensory neuropathy | 147.27 | 18.70 | 86 | 34702 | 11292 | 64452652 |
Neutropenic sepsis | 141.46 | 18.70 | 110 | 34678 | 23162 | 64440782 |
Alopecia | 136.61 | 18.70 | 286 | 34502 | 165404 | 64298540 |
Stomatitis | 128.60 | 18.70 | 220 | 34568 | 109385 | 64354559 |
Left ventricular dysfunction | 125.04 | 18.70 | 90 | 34698 | 16864 | 64447080 |
Palmar-plantar erythrodysaesthesia syndrome | 118.97 | 18.70 | 109 | 34679 | 28710 | 64435234 |
Metastases to bone | 118.60 | 18.70 | 94 | 34694 | 20341 | 64443603 |
Drug interaction | 115.28 | 18.70 | 27 | 34761 | 362056 | 64101888 |
Fall | 114.54 | 18.70 | 41 | 34747 | 416785 | 64047159 |
Interstitial lung disease | 100.23 | 18.70 | 185 | 34603 | 97547 | 64366397 |
Fatigue | 99.29 | 18.70 | 716 | 34072 | 748014 | 63715930 |
Metastases to lung | 99.00 | 18.70 | 75 | 34713 | 15189 | 64448755 |
Nail toxicity | 96.93 | 18.70 | 25 | 34763 | 331 | 64463613 |
Epistaxis | 94.72 | 18.70 | 181 | 34607 | 97950 | 64365994 |
Off label use | 91.93 | 18.70 | 619 | 34169 | 632187 | 63831757 |
Skin toxicity | 88.35 | 18.70 | 51 | 34737 | 6551 | 64457393 |
Dysgeusia | 87.32 | 18.70 | 117 | 34671 | 46930 | 64417014 |
Vascular device infection | 86.07 | 18.70 | 49 | 34739 | 6131 | 64457813 |
Bone pain | 84.79 | 18.70 | 116 | 34672 | 47456 | 64416488 |
Nail dystrophy | 84.70 | 18.70 | 27 | 34761 | 786 | 64463158 |
Lymphoedema | 83.32 | 18.70 | 57 | 34731 | 9848 | 64454096 |
Product dose omission issue | 82.00 | 18.70 | 6 | 34782 | 194741 | 64269203 |
Nausea | 81.86 | 18.70 | 711 | 34077 | 785089 | 63678855 |
Hypokalaemia | 80.81 | 18.70 | 193 | 34595 | 121710 | 64342234 |
Metastases to liver | 80.71 | 18.70 | 81 | 34707 | 23860 | 64440084 |
Nail discolouration | 77.10 | 18.70 | 34 | 34754 | 2466 | 64461478 |
Onycholysis | 76.86 | 18.70 | 30 | 34758 | 1596 | 64462348 |
Vomiting | 76.30 | 18.70 | 533 | 34255 | 550584 | 63913360 |
Pneumonitis | 73.93 | 18.70 | 112 | 34676 | 50253 | 64413691 |
Nail disorder | 73.42 | 18.70 | 50 | 34738 | 8574 | 64455370 |
Cardiac dysfunction | 73.07 | 18.70 | 35 | 34753 | 3071 | 64460873 |
Cardiomyopathy | 71.54 | 18.70 | 78 | 34710 | 25278 | 64438666 |
Toxicity to various agents | 70.17 | 18.70 | 56 | 34732 | 363457 | 64100487 |
Decreased appetite | 69.45 | 18.70 | 318 | 34470 | 280971 | 64182973 |
Lacrimation increased | 69.18 | 18.70 | 66 | 34722 | 18280 | 64445664 |
Breast pain | 65.06 | 18.70 | 43 | 34745 | 7018 | 64456926 |
Tonsillar disorder | 63.84 | 18.70 | 23 | 34765 | 978 | 64462966 |
Drug hypersensitivity | 62.54 | 18.70 | 25 | 34763 | 237790 | 64226154 |
Erysipelas | 59.72 | 18.70 | 45 | 34743 | 9036 | 64454908 |
Condition aggravated | 59.47 | 18.70 | 68 | 34720 | 372358 | 64091586 |
Joint swelling | 59.38 | 18.70 | 21 | 34767 | 215361 | 64248583 |
Constipation | 59.37 | 18.70 | 263 | 34525 | 229074 | 64234870 |
Drug abuse | 58.96 | 18.70 | 3 | 34785 | 132371 | 64331573 |
Cellulitis | 57.49 | 18.70 | 144 | 34644 | 93513 | 64370431 |
Confusional state | 57.28 | 18.70 | 35 | 34753 | 261109 | 64202835 |
Device related infection | 56.57 | 18.70 | 76 | 34712 | 30550 | 64433394 |
Metastasis | 55.69 | 18.70 | 36 | 34752 | 5659 | 64458285 |
Lower respiratory tract infection | 54.47 | 18.70 | 142 | 34646 | 94472 | 64369472 |
Radiation skin injury | 54.04 | 18.70 | 22 | 34766 | 1308 | 64462636 |
Arthropathy | 53.06 | 18.70 | 3 | 34785 | 120964 | 64342980 |
Mastectomy | 52.46 | 18.70 | 20 | 34768 | 998 | 64462946 |
Mastitis | 52.08 | 18.70 | 24 | 34764 | 1930 | 64462014 |
Breast cancer recurrent | 51.49 | 18.70 | 26 | 34762 | 2557 | 64461387 |
Infusion related reaction | 50.67 | 18.70 | 199 | 34589 | 164268 | 64299676 |
Breast cancer metastatic | 50.45 | 18.70 | 37 | 34751 | 7132 | 64456812 |
Therapeutic product effect decreased | 50.17 | 18.70 | 3 | 34785 | 115348 | 64348596 |
Myocardial infarction | 49.56 | 18.70 | 14 | 34774 | 165807 | 64298137 |
Pleural effusion | 49.03 | 18.70 | 165 | 34623 | 126394 | 64337550 |
Neoplasm progression | 49 | 18.70 | 83 | 34705 | 40881 | 64423063 |
Metastases to lymph nodes | 48.23 | 18.70 | 39 | 34749 | 8678 | 64455266 |
Drug intolerance | 47.42 | 18.70 | 21 | 34767 | 187971 | 64275973 |
Bradycardia | 46.08 | 18.70 | 5 | 34783 | 118214 | 64345730 |
Onychalgia | 45.95 | 18.70 | 17 | 34771 | 780 | 64463164 |
Pseudocirrhosis | 45.61 | 18.70 | 16 | 34772 | 629 | 64463315 |
Madarosis | 45.12 | 18.70 | 23 | 34765 | 2307 | 64461637 |
Cystitis noninfective | 43.93 | 18.70 | 18 | 34770 | 1088 | 64462856 |
Cardiac failure | 43.91 | 18.70 | 164 | 34624 | 132209 | 64331735 |
Tumour pain | 43.11 | 18.70 | 21 | 34767 | 1912 | 64462032 |
Hyperkalaemia | 42.88 | 18.70 | 3 | 34785 | 101126 | 64362818 |
Injection site pain | 42.70 | 18.70 | 5 | 34783 | 111403 | 64352541 |
Paraesthesia | 42.42 | 18.70 | 164 | 34624 | 134358 | 64329586 |
Carbohydrate antigen 15-3 increased | 42.42 | 18.70 | 17 | 34771 | 970 | 64462974 |
Excessive eye blinking | 41.66 | 18.70 | 18 | 34770 | 1242 | 64462702 |
Aortitis | 40.62 | 18.70 | 17 | 34771 | 1084 | 64462860 |
Abdominal discomfort | 40.57 | 18.70 | 24 | 34764 | 182298 | 64281646 |
Nasal disorder | 40.52 | 18.70 | 23 | 34765 | 2861 | 64461083 |
Red cell distribution width increased | 40.30 | 18.70 | 41 | 34747 | 12268 | 64451676 |
Gastrointestinal haemorrhage | 39.85 | 18.70 | 11 | 34777 | 132301 | 64331643 |
Vessel puncture site bruise | 39.76 | 18.70 | 13 | 34775 | 411 | 64463533 |
Product use in unapproved indication | 39.65 | 18.70 | 23 | 34765 | 176595 | 64287349 |
Musculoskeletal stiffness | 39.51 | 18.70 | 9 | 34779 | 123197 | 64340747 |
Meibomian gland dysfunction | 39.08 | 18.70 | 10 | 34778 | 128 | 64463816 |
Hyperfibrinogenaemia | 38.78 | 18.70 | 9 | 34779 | 74 | 64463870 |
Dyspnoea | 38.69 | 18.70 | 572 | 34216 | 718102 | 63745842 |
Gastrointestinal toxicity | 38.66 | 18.70 | 28 | 34760 | 5294 | 64458650 |
Somnolence | 38.46 | 18.70 | 32 | 34756 | 203613 | 64260331 |
Inappropriate schedule of product administration | 38.38 | 18.70 | 3 | 34785 | 92283 | 64371661 |
Hot flush | 38.23 | 18.70 | 80 | 34708 | 46155 | 64417789 |
Rhabdomyolysis | 38.10 | 18.70 | 3 | 34785 | 91723 | 64372221 |
Dehydration | 38.08 | 18.70 | 223 | 34565 | 216540 | 64247404 |
Hypertransaminasaemia | 37.32 | 18.70 | 31 | 34757 | 7160 | 64456784 |
Urinary tract infection | 36.71 | 18.70 | 232 | 34556 | 231364 | 64232580 |
Gait disturbance | 36.45 | 18.70 | 24 | 34764 | 172131 | 64291813 |
White blood cell count abnormal | 36.31 | 18.70 | 26 | 34762 | 4828 | 64459116 |
Hyperpyrexia | 35.27 | 18.70 | 26 | 34762 | 5051 | 64458893 |
Dry skin | 34.94 | 18.70 | 82 | 34706 | 51079 | 64412865 |
Vascular fragility | 34.77 | 18.70 | 9 | 34779 | 121 | 64463823 |
Chest discomfort | 34.54 | 18.70 | 139 | 34649 | 115967 | 64347977 |
Hypoglycaemia | 34.53 | 18.70 | 4 | 34784 | 89888 | 64374056 |
Cardio-respiratory arrest | 34.02 | 18.70 | 6 | 34782 | 98387 | 64365557 |
Blood creatine increased | 33.82 | 18.70 | 31 | 34757 | 8161 | 64455783 |
Biliary sepsis | 33.31 | 18.70 | 16 | 34772 | 1412 | 64462532 |
Depressed level of consciousness | 32.90 | 18.70 | 3 | 34785 | 81433 | 64382511 |
Colitis | 32.67 | 18.70 | 87 | 34701 | 58587 | 64405357 |
Post-traumatic pain | 32.36 | 18.70 | 11 | 34777 | 393 | 64463551 |
Anaemia | 32.32 | 18.70 | 329 | 34459 | 378351 | 64085593 |
Alopecia areata | 32.28 | 18.70 | 16 | 34772 | 1512 | 64462432 |
Nail infection | 32.23 | 18.70 | 17 | 34771 | 1830 | 64462114 |
Hepatic enzyme increased | 32.01 | 18.70 | 15 | 34773 | 129928 | 64334016 |
Paronychia | 31.66 | 18.70 | 27 | 34761 | 6465 | 64457479 |
Acute interstitial pneumonitis | 31.51 | 18.70 | 14 | 34774 | 1033 | 64462911 |
Rhinorrhoea | 31.47 | 18.70 | 87 | 34701 | 59882 | 64404062 |
Hypoaesthesia | 31.14 | 18.70 | 153 | 34635 | 138955 | 64324989 |
Nail bed bleeding | 30.71 | 18.70 | 10 | 34778 | 312 | 64463632 |
Dyspepsia | 30.46 | 18.70 | 104 | 34684 | 80208 | 64383736 |
Metastases to skin | 30.07 | 18.70 | 15 | 34773 | 1437 | 64462507 |
Sinusitis | 30.01 | 18.70 | 21 | 34767 | 145907 | 64318037 |
Hepatic lesion | 30.01 | 18.70 | 25 | 34763 | 5799 | 64458145 |
Hair texture abnormal | 29.40 | 18.70 | 19 | 34769 | 2985 | 64460959 |
Vaginal prolapse | 28.73 | 18.70 | 9 | 34779 | 247 | 64463697 |
Exposure during pregnancy | 28.52 | 18.70 | 4 | 34784 | 77671 | 64386273 |
Hypothalamo-pituitary disorder | 28.38 | 18.70 | 13 | 34775 | 1031 | 64462913 |
HER2 positive breast cancer | 28.36 | 18.70 | 9 | 34779 | 258 | 64463686 |
Folate deficiency | 28.34 | 18.70 | 18 | 34770 | 2745 | 64461199 |
Osteitis condensans | 28.26 | 18.70 | 6 | 34782 | 31 | 64463913 |
Neurotoxicity | 28.21 | 18.70 | 52 | 34736 | 27352 | 64436592 |
Mobility decreased | 28.06 | 18.70 | 6 | 34782 | 85834 | 64378110 |
Metastases to meninges | 28.03 | 18.70 | 18 | 34770 | 2797 | 64461147 |
Overdose | 27.81 | 18.70 | 27 | 34761 | 159539 | 64304405 |
Feeling abnormal | 27.77 | 18.70 | 19 | 34769 | 133583 | 64330361 |
Pituitary tumour | 27.66 | 18.70 | 13 | 34775 | 1093 | 64462851 |
Axillary pain | 27.58 | 18.70 | 15 | 34773 | 1717 | 64462227 |
Pyrexia | 27.43 | 18.70 | 438 | 34350 | 558206 | 63905738 |
Skin infection | 27.28 | 18.70 | 37 | 34751 | 15000 | 64448944 |
Arthritis | 27.11 | 18.70 | 6 | 34782 | 83808 | 64380136 |
Renal impairment | 27.02 | 18.70 | 20 | 34768 | 134997 | 64328947 |
Therapeutic product effect incomplete | 26.98 | 18.70 | 11 | 34777 | 103471 | 64360473 |
Tongue coated | 26.96 | 18.70 | 13 | 34775 | 1157 | 64462787 |
Cardiac arrest | 26.93 | 18.70 | 26 | 34762 | 154038 | 64309906 |
Delirium | 26.78 | 18.70 | 3 | 34785 | 69191 | 64394753 |
Haemorrhoids | 26.57 | 18.70 | 47 | 34741 | 23954 | 64439990 |
Onychoclasis | 26.37 | 18.70 | 21 | 34767 | 4571 | 64459373 |
Breast inflammation | 26.15 | 18.70 | 7 | 34781 | 108 | 64463836 |
Hallucination | 26.14 | 18.70 | 4 | 34784 | 72784 | 64391160 |
Systolic dysfunction | 25.92 | 18.70 | 18 | 34770 | 3184 | 64460760 |
Hair colour changes | 25.69 | 18.70 | 19 | 34769 | 3708 | 64460236 |
Pain | 25.68 | 18.70 | 184 | 34604 | 553327 | 63910617 |
Osteolysis | 25.65 | 18.70 | 17 | 34771 | 2786 | 64461158 |
Cerebrovascular accident | 25.50 | 18.70 | 22 | 34766 | 137561 | 64326383 |
Pulmonary hypoplasia | 25.47 | 18.70 | 6 | 34782 | 53 | 64463891 |
Suicidal ideation | 25.46 | 18.70 | 3 | 34785 | 66539 | 64397405 |
Enterocolitis infectious | 25.14 | 18.70 | 16 | 34772 | 2448 | 64461496 |
Coma | 25.07 | 18.70 | 8 | 34780 | 87607 | 64376337 |
Blood magnesium decreased | 24.90 | 18.70 | 34 | 34754 | 13871 | 64450073 |
Mean platelet volume decreased | 24.84 | 18.70 | 14 | 34774 | 1717 | 64462227 |
Catheter site pain | 24.76 | 18.70 | 20 | 34768 | 4442 | 64459502 |
Therapy partial responder | 24.61 | 18.70 | 29 | 34759 | 10219 | 64453725 |
Osteosclerosis | 24.55 | 18.70 | 18 | 34770 | 3468 | 64460476 |
Gastritis | 24.55 | 18.70 | 64 | 34724 | 42554 | 64421390 |
Hyperchlorhydria | 24.34 | 18.70 | 14 | 34774 | 1785 | 64462159 |
Systemic lupus erythematosus | 24.22 | 18.70 | 6 | 34782 | 77606 | 64386338 |
Perforation | 24.19 | 18.70 | 12 | 34776 | 1136 | 64462808 |
Osteonecrosis of jaw | 24.17 | 18.70 | 61 | 34727 | 39764 | 64424180 |
Tidal volume decreased | 24.04 | 18.70 | 6 | 34782 | 69 | 64463875 |
Metastases to spine | 23.84 | 18.70 | 18 | 34770 | 3625 | 64460319 |
Urinary tract disorder | 23.78 | 18.70 | 17 | 34771 | 3149 | 64460795 |
Agitation | 23.68 | 18.70 | 9 | 34779 | 88358 | 64375586 |
Keratitis | 23.44 | 18.70 | 17 | 34771 | 3220 | 64460724 |
Onychomadesis | 22.85 | 18.70 | 16 | 34772 | 2868 | 64461076 |
Dental fistula | 22.74 | 18.70 | 9 | 34779 | 497 | 64463447 |
Odynophagia | 22.68 | 18.70 | 27 | 34761 | 9614 | 64454330 |
Treatment failure | 22.48 | 18.70 | 18 | 34770 | 116798 | 64347146 |
Coronary artery disease | 22.45 | 18.70 | 3 | 34785 | 60430 | 64403514 |
Palmar erythema | 22.32 | 18.70 | 13 | 34775 | 1697 | 64462247 |
Postural orthostatic tachycardia syndrome | 22.23 | 18.70 | 9 | 34779 | 527 | 64463417 |
Back pain | 22.10 | 18.70 | 219 | 34569 | 249952 | 64213992 |
Nasal congestion | 22.07 | 18.70 | 3 | 34785 | 59655 | 64404289 |
Sarcoid-like reaction | 22.06 | 18.70 | 4 | 34784 | 7 | 64463937 |
Pneumonitis chemical | 22.01 | 18.70 | 8 | 34780 | 349 | 64463595 |
Asthma | 21.94 | 18.70 | 12 | 34776 | 95213 | 64368731 |
Blood glucose increased | 21.68 | 18.70 | 13 | 34775 | 98060 | 64365884 |
Osteoarthritis | 21.60 | 18.70 | 4 | 34784 | 63332 | 64400612 |
Electrocardiogram QT prolonged | 21.44 | 18.70 | 8 | 34780 | 79440 | 64384504 |
Respiratory tract infection | 21.36 | 18.70 | 56 | 34732 | 37351 | 64426593 |
Renal failure | 21.32 | 18.70 | 41 | 34747 | 181647 | 64282297 |
Metastases to soft tissue | 21.28 | 18.70 | 8 | 34780 | 384 | 64463560 |
Weight increased | 21.04 | 18.70 | 53 | 34735 | 213295 | 64250649 |
Flushing | 20.91 | 18.70 | 91 | 34697 | 78557 | 64385387 |
Influenza like illness | 20.90 | 18.70 | 77 | 34711 | 61625 | 64402319 |
Paralysis recurrent laryngeal nerve | 20.86 | 18.70 | 6 | 34782 | 122 | 64463822 |
Dandy-Walker syndrome | 20.85 | 18.70 | 5 | 34783 | 48 | 64463896 |
Subcutaneous abscess | 20.42 | 18.70 | 22 | 34766 | 7031 | 64456913 |
Borrelia infection | 20.33 | 18.70 | 6 | 34782 | 134 | 64463810 |
Corneal disorder | 20.28 | 18.70 | 13 | 34775 | 2014 | 64461930 |
Disorientation | 20.20 | 18.70 | 3 | 34785 | 55825 | 64408119 |
Dysuria | 20.10 | 18.70 | 59 | 34729 | 41998 | 64421946 |
Mucosal dryness | 20.02 | 18.70 | 15 | 34773 | 2986 | 64460958 |
Appendiceal abscess | 19.96 | 18.70 | 7 | 34781 | 275 | 64463669 |
Spinal pain | 19.84 | 18.70 | 29 | 34759 | 12592 | 64451352 |
Myalgia | 19.84 | 18.70 | 150 | 34638 | 158467 | 64305477 |
Product use issue | 19.82 | 18.70 | 32 | 34756 | 151683 | 64312261 |
Pleural disorder | 19.54 | 18.70 | 9 | 34779 | 723 | 64463221 |
Enterocolitis | 19.46 | 18.70 | 28 | 34760 | 11990 | 64451954 |
Rectal haemorrhage | 19.17 | 18.70 | 75 | 34713 | 61742 | 64402202 |
Discomfort | 18.91 | 18.70 | 10 | 34778 | 80868 | 64383076 |
Nail bed tenderness | 18.80 | 18.70 | 7 | 34781 | 327 | 64463617 |
Wheezing | 18.78 | 18.70 | 10 | 34778 | 80569 | 64383375 |
Urogenital prolapse | 18.78 | 18.70 | 4 | 34784 | 21 | 64463923 |
None
Source | Code | Description |
---|---|---|
ATC | L01FD02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors |
ATC | L01XY02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Combinations of antineoplastic agents |
FDA MoA | N0000020008 | HER2/Neu/cerbB2 Antagonists |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000074322 | Antineoplastic Agents, Immunological |
FDA EPC | N0000175661 | HER2/neu Receptor Antagonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
HER2-positive carcinoma of breast | indication | 427685000 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Receptor tyrosine-protein kinase erbB-2 | Kinase | ANTIBODY BINDING | UNKNOWN | DRUG LABEL |
ID | Source |
---|---|
D05446 | KEGG_DRUG |
4031566 | VUID |
N0000185031 | NUI |
4031566 | VANDF |
CHEMBL2007641 | ChEMBL_ID |
C485206 | MESH_SUPPLEMENTAL_RECORD_UI |
5046 | IUPHAR_LIGAND_ID |
8380 | INN_ID |
DB06366 | DRUGBANK_ID |
K16AIQ8CTM | UNII |
1298944 | RXNORM |
190566 | MMSL |
28589 | MMSL |
d07874 | MMSL |
704226002 | SNOMEDCT_US |
704227006 | SNOMEDCT_US |
C1328025 | UMLSCUI |
014427 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
PERJETA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-145 | INJECTION, SOLUTION, CONCENTRATE | 30 mg | INTRAVENOUS | BLA | 31 sections |
Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-245 | INJECTION, SOLUTION | 1200 mg | SUBCUTANEOUS | BLA | 30 sections |
Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-260 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |