pertuzumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4957 380610-27-5

Description:

MoleculeDescription

Synonyms:

  • pertuzumab
  • perjeta
  • rhuMAb 2C4
  • pertuzumab (genetical recombination)
a humanized HER-2 monoclonal antibody; prevents ERBB2 receptor protein from binding (dimerizing) to other receptors in the HER family
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 8, 2012 FDA GENENTECH
March 4, 2013 EMA
June 28, 2013 PMDA Chugai Pharmaceutical

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 3898.11 18.36 1442 60894 52149 90513962
Diarrhoea 1635.42 18.36 2556 59780 936634 89629477
Ejection fraction decreased 1277.82 18.36 529 61807 25724 90540387
Metastases to central nervous system 1010.21 18.36 399 61937 17143 90548968
Disease progression 991.08 18.36 837 61499 155778 90410333
Neuropathy peripheral 709.91 18.36 654 61682 136316 90429795
Polyneuropathy 658.08 18.36 303 62033 19038 90547073
Febrile neutropenia 517.62 18.36 590 61746 157759 90408352
Neutropenia 473.37 18.36 673 61663 224231 90341880
Cardiotoxicity 433.53 18.36 193 62143 11196 90554915
Mucosal inflammation 422.50 18.36 336 62000 57289 90508822
Chills 346.23 18.36 440 61896 131541 90434570
Palmar-plantar erythrodysaesthesia syndrome 318.31 18.36 213 62123 27810 90538301
Left ventricular dysfunction 300.78 18.36 163 62173 14506 90551605
Interstitial lung disease 282.65 18.36 304 62032 76101 90490010
Metastases to lung 279.56 18.36 160 62176 15831 90550280
Cardiac dysfunction 265.10 18.36 98 62238 3499 90562612
Vascular device infection 256.78 18.36 137 62199 11815 90554296
Metastases to bone 249.88 18.36 177 62159 25328 90540783
Joint swelling 238.78 18.36 32 62304 503268 90062843
Metastases to liver 235.00 18.36 179 62157 28628 90537483
Arthropathy 231.83 18.36 4 62332 366238 90199873
Peripheral sensory neuropathy 230.14 18.36 117 62219 9133 90556978
Rheumatoid arthritis 229.37 18.36 4 62332 362610 90203501
Drug ineffective 222.99 18.36 383 61953 1383915 89182196
Anaemia 219.74 18.36 635 61701 352167 90213944
Metastases to lymph nodes 217.94 18.36 122 62214 11567 90554544
Epistaxis 213.99 18.36 278 62058 84847 90481264
Pneumonitis 211.30 18.36 202 62134 43968 90522143
Neutrophil count decreased 210.82 18.36 253 62083 71279 90494832
Systemic lupus erythematosus 210.50 18.36 9 62327 361887 90204224
Abdominal discomfort 206.90 18.36 39 62297 477289 90088822
Neutropenic sepsis 196.77 18.36 134 62202 17996 90548115
Drug hypersensitivity 180.58 18.36 48 62288 463561 90102550
Off label use 171.54 18.36 1318 61018 1100934 89465177
Cardiac failure 171.29 18.36 286 62050 109210 90456901
Hypokalaemia 168.31 18.36 314 62022 130802 90435309
Pleural effusion 161.32 18.36 282 62054 111709 90454402
Therapeutic product effect decreased 161.05 18.36 7 62329 277564 90288547
Metastasis 159.62 18.36 80 62256 6057 90560054
Hepatic function abnormal 158.65 18.36 177 62159 46111 90520000
Pericarditis 152.91 18.36 8 62328 270143 90295968
Musculoskeletal stiffness 152.75 18.36 14 62322 296518 90269593
Breast cancer metastatic 150.49 18.36 106 62230 15026 90551085
Neoplasm progression 148.86 18.36 168 62168 44318 90521793
Paronychia 145.02 18.36 82 62254 7924 90558187
Product dose omission issue 144.44 18.36 16 62320 291671 90274440
Platelet count decreased 144.36 18.36 302 62034 136667 90429444
Skin toxicity 143.63 18.36 77 62259 6702 90559409
Dysgeusia 142.06 18.36 178 62158 52382 90513729
Cardiomyopathy 139.89 18.36 114 62222 20092 90546019
Exposure during pregnancy 138.34 18.36 6 62330 238404 90327707
Glossodynia 135.74 18.36 28 62308 321751 90244360
Hyperpyrexia 135.53 18.36 66 62270 4695 90561416
Mobility decreased 134.20 18.36 10 62326 250724 90315387
Breast cancer recurrent 132.23 18.36 68 62268 5435 90560676
White blood cell count decreased 131.25 18.36 328 62008 166781 90399330
Confusional state 130.84 18.36 51 62285 386154 90179957
Wound 130.65 18.36 25 62311 302955 90263156
Duodenal ulcer perforation 130.30 18.36 5 62331 221283 90344828
Pain 128.14 18.36 313 62023 996028 89570083
Sinusitis 127.09 18.36 39 62297 343049 90223062
Condition aggravated 126.51 18.36 134 62202 595411 89970700
Impaired healing 126.31 18.36 9 62327 234190 90331921
Discomfort 124.03 18.36 20 62316 274315 90291796
Hepatic enzyme increased 123.25 18.36 47 62289 360689 90205422
Lymphoedema 122.26 18.36 90 62246 13663 90552448
Swelling 120.98 18.36 69 62267 418989 90147122
Nausea 117.36 18.36 1221 61115 1109095 89457016
Drug intolerance 115.16 18.36 84 62252 447507 90118604
Maternal exposure during pregnancy 114.80 18.36 52 62284 360011 90206100
Thrombocytopenia 113.97 18.36 359 61977 208366 90357745
Erysipelas 112.97 18.36 73 62263 8979 90557132
Onycholysis 111.99 18.36 46 62290 2184 90563927
Injury 111.16 18.36 6 62330 197343 90368768
Vomiting 110.87 18.36 922 61414 787371 89778740
Osteoarthritis 110.10 18.36 6 62330 195724 90370387
Treatment failure 109.96 18.36 36 62300 303892 90262219
Bone pain 109.29 18.36 171 62165 61812 90504299
Fall 104.98 18.36 106 62230 481704 90084407
Blood cholesterol increased 104.00 18.36 11 62325 208001 90358110
Metastases to skin 103.60 18.36 43 62293 2097 90564014
Granulocyte count decreased 101.21 18.36 44 62292 2408 90563703
Nail dystrophy 101.15 18.36 37 62299 1281 90564830
Type 2 diabetes mellitus 100.96 18.36 11 62325 203233 90362878
Pyrexia 98.98 18.36 784 61552 659701 89906410
Irritable bowel syndrome 98.68 18.36 13 62323 207435 90358676
Radiation skin injury 96.15 18.36 34 62302 1066 90565045
Nail toxicity 95.94 18.36 27 62309 391 90565720
Mastitis 95.88 18.36 45 62291 2948 90563163
Asthma 94.31 18.36 25 62311 242135 90323976
Device related infection 94.23 18.36 102 62234 25684 90540427
Dermatitis acneiform 93.78 18.36 57 62279 6297 90559814
Neurotoxicity 91.13 18.36 92 62244 21375 90544736
Malignant neoplasm progression 89.42 18.36 215 62121 106655 90459456
Product use in unapproved indication 89.21 18.36 61 62275 336175 90229936
Psoriasis 88.14 18.36 3 62333 147751 90418360
Weight increased 87.57 18.36 95 62241 417832 90148279
Nail discolouration 86.49 18.36 43 62293 3199 90562912
Skin fissures 86.18 18.36 88 62248 20721 90545390
Folliculitis 85.68 18.36 18 62318 204335 90361776
Injection site pain 84.77 18.36 10 62326 173689 90392422
Wheezing 84.70 18.36 29 62307 238051 90328060
Lacrimation increased 83.45 18.36 98 62238 26964 90539147
Product use issue 83.41 18.36 63 62273 329856 90236255
Mastectomy 81.24 18.36 36 62300 2063 90564048
Joint range of motion decreased 80.05 18.36 3 62333 135640 90430471
Metastases to meninges 77.94 18.36 42 62294 3693 90562418
Nail bed inflammation 76.57 18.36 33 62303 1768 90564343
Breast neoplasm 73.97 18.36 31 62305 1549 90564562
Decreased appetite 73.69 18.36 477 61859 376063 90190048
Blister 73.50 18.36 42 62294 254956 90311155
Dehydration 73.11 18.36 296 62040 194151 90371960
Ventricular dysfunction 72.44 18.36 40 62296 3691 90562420
Chest discomfort 71.84 18.36 234 62102 138131 90427980
Urticaria 71.31 18.36 66 62270 312668 90253443
Contusion 70.12 18.36 43 62293 251173 90314938
Recall phenomenon 69.51 18.36 25 62311 824 90565287
Tumour pain 68.68 18.36 31 62305 1856 90564255
Breast pain 68.39 18.36 57 62279 10361 90555750
Cellulitis 68.23 18.36 176 62160 91161 90474950
Depression 67.87 18.36 64 62272 300537 90265574
Cystitis haemorrhagic 67.66 18.36 44 62292 5469 90560642
Arthritis 67.59 18.36 16 62320 167299 90398812
Streptococcal sepsis 65.70 18.36 37 62299 3547 90562564
Inappropriate schedule of product administration 65.38 18.36 12 62324 149921 90416190
Constipation 62.88 18.36 368 61968 280027 90286084
HER2 positive breast cancer 62.83 18.36 20 62316 450 90565661
Arthralgia 62.70 18.36 299 62037 778223 89787888
Drug interaction 62.24 18.36 59 62277 276394 90289717
Gait inability 61.18 18.36 13 62323 146443 90419668
Tonsillar disorder 61.06 18.36 25 62311 1177 90564934
Osteonecrosis of jaw 60.91 18.36 102 62234 39001 90527110
Haematotoxicity 59.30 18.36 57 62279 12478 90553633
Bone marrow infiltration 58.60 18.36 22 62314 820 90565291
Gait disturbance 58.17 18.36 56 62280 260440 90305671
Inflammation 58.12 18.36 25 62311 178567 90387544
Excessive eye blinking 57.87 18.36 25 62311 1347 90564764
Obesity 57.01 18.36 4 62332 105503 90460608
Nasal mucosal disorder 56.66 18.36 27 62309 1830 90564281
Onychoclasis 56.01 18.36 44 62292 7355 90558756
Hyperfibrinogenaemia 55.49 18.36 11 62325 27 90566084
Sarcoid-like reaction 55.37 18.36 15 62321 187 90565924
Sleep disorder 55.11 18.36 34 62302 197996 90368115
Fatigue 55.10 18.36 1105 61231 1152918 89413193
Cystitis noninfective 54.66 18.36 24 62312 1345 90564766
Breast disorder 54.64 18.36 30 62306 2737 90563374
Metastases to spine 53.76 18.36 33 62303 3710 90562401
Peripheral swelling 52.68 18.36 130 62206 412976 90153135
Colitis 52.47 18.36 135 62201 69807 90496304
Meibomian gland dysfunction 51.28 18.36 15 62321 251 90565860
Hot flush 51.16 18.36 121 62215 59367 90506744
Leukopenia 51.08 18.36 169 62167 100541 90465570
Gastrointestinal toxicity 50.46 18.36 46 62290 9421 90556690
Blood magnesium decreased 50.34 18.36 58 62278 15635 90550476
Migraine 49.85 18.36 35 62301 190357 90375754
Pseudomonal sepsis 49.55 18.36 33 62303 4269 90561842
Pseudocirrhosis 49.20 18.36 20 62316 924 90565187
Anaphylactic shock 48.61 18.36 82 62254 31535 90534576
Aortitis 48.57 18.36 22 62314 1328 90564783
Delirium 48.52 18.36 7 62329 104352 90461759
Nail infection 48.36 18.36 27 62309 2545 90563566
Myalgia 48.11 18.36 243 62093 174882 90391229
Therapeutic product effect incomplete 47.73 18.36 38 62298 193858 90372253
Dry skin 47.56 18.36 151 62185 87922 90478189
Agranulocytosis 46.33 18.36 85 62251 34917 90531194
Metastatic neoplasm 46.19 18.36 33 62303 4782 90561329
Adverse event 45.92 18.36 12 62324 117406 90448705
Mucosal dryness 45.69 18.36 28 62308 3139 90562972
Enterocolitis infectious 45.47 18.36 24 62312 2023 90564088
Flushing 45.32 18.36 149 62187 88342 90477769
Drug abuse 44.85 18.36 3 62333 82344 90483767
Dyspnoea 44.80 18.36 852 61484 880103 89686008
Lymphadenopathy 44.80 18.36 98 62238 45677 90520434
Madarosis 44.63 18.36 29 62307 3600 90562511
Nodular regenerative hyperplasia 44.48 18.36 17 62319 666 90565445
Hypertransaminasaemia 43.39 18.36 54 62282 15771 90550340
Pneumonitis chemical 43.32 18.36 14 62322 331 90565780
Hand dermatitis 43.15 18.36 16 62320 576 90565535
Hepatotoxicity 42.45 18.36 96 62240 45746 90520365
Hemianopia 42.29 18.36 23 62313 2059 90564052
Anxiety 42.26 18.36 94 62242 309678 90256433
Memory impairment 42.19 18.36 44 62292 197200 90368911
Radiation pneumonitis 41.89 18.36 22 62314 1836 90564275
Biliary sepsis 41.70 18.36 18 62318 968 90565143
Congestive cardiomyopathy 41.69 18.36 37 62299 7317 90558794
Microvascular coronary artery disease 41.68 18.36 13 62323 273 90565838
Osteoporosis 41.49 18.36 8 62328 96523 90469588
Recurrent cancer 41.36 18.36 24 62312 2435 90563676
Sciatica 40.34 18.36 10 62326 101372 90464739
Therapy non-responder 40.11 18.36 22 62314 136682 90429429
Somnolence 40.01 18.36 51 62285 209033 90357078
Mitral valve incompetence 39.49 18.36 62 62274 22462 90543649
Stomatitis 39.28 18.36 323 62013 274375 90291736
Musculoskeletal pain 39.17 18.36 36 62300 171215 90394896
Back pain 39.14 18.36 361 61975 316814 90249297
Onychalgia 38.98 18.36 18 62318 1136 90564975
Red cell distribution width increased 38.96 18.36 45 62291 12162 90553949
Neck pain 38.61 18.36 15 62321 113948 90452163
Systolic dysfunction 38.58 18.36 21 62315 1883 90564228
Autoimmune disorder 38.49 18.36 4 62332 76740 90489371
Folate deficiency 38.21 18.36 25 62311 3140 90562971
Hypomagnesaemia 38.06 18.36 79 62257 35509 90530602
Dyschezia 37.97 18.36 24 62312 2841 90563270
Product quality issue 37.63 18.36 5 62331 79320 90486791
Central vision loss 37.63 18.36 9 62327 65 90566046
Nasal disorder 37.31 18.36 25 62311 3267 90562844
Feeling abnormal 37.26 18.36 36 62300 167199 90398912
Asthenia 36.91 18.36 543 61793 533208 90032903
Metastases to soft tissue 36.85 18.36 12 62324 291 90565820
Ear infection 36.69 18.36 3 62333 69772 90496339
Suicidal ideation 36.65 18.36 4 62332 73851 90492260
Brain oedema 36.40 18.36 52 62284 17333 90548778
Therapy partial responder 36.35 18.36 59 62277 21984 90544127
Pulmonary embolism 36.25 18.36 182 62154 130638 90435473
Vessel puncture site bruise 35.73 18.36 13 62323 443 90565668
Hyperchlorhydria 35.47 18.36 20 62316 1921 90564190
Injection site reaction 34.90 18.36 10 62326 92070 90474041
Acute interstitial pneumonitis 34.79 18.36 15 62321 804 90565307
Alopecia areata 34.78 18.36 20 62316 1995 90564116
Drug ineffective for unapproved indication 34.67 18.36 3 62333 66641 90499470
Transaminases increased 34.56 18.36 78 62258 37114 90528997
Medication error 34.37 18.36 8 62328 84644 90481467
Radiation necrosis 34.20 18.36 14 62322 659 90565452
Intracranial pressure increased 34.18 18.36 32 62304 6779 90559332
Stress cardiomyopathy 34.12 18.36 44 62292 13311 90552800
Vulvovaginal dryness 34.03 18.36 24 62312 3407 90562704
Pericardial effusion 33.95 18.36 77 62259 36756 90529355
Adverse drug reaction 33.92 18.36 19 62317 116682 90449429
Bradycardia 33.89 18.36 8 62328 83839 90482272
Nasal congestion 33.63 18.36 8 62328 83406 90482705
Blood creatine increased 33.56 18.36 32 62304 6935 90559176
Breast inflammation 33.05 18.36 10 62326 189 90565922
Nail bed bleeding 32.82 18.36 12 62324 415 90565696
Infection 32.73 18.36 133 62203 361961 90204150
Ventricular hypokinesia 32.55 18.36 28 62308 5313 90560798
Varicose vein 32.19 18.36 32 62304 7295 90558816
Metastases to pleura 31.88 18.36 19 62317 2025 90564086
Metastases to bone marrow 31.87 18.36 13 62323 606 90565505
Toxicity to various agents 31.86 18.36 97 62239 287749 90278362
Seroma 31.74 18.36 22 62314 3038 90563073
Overdose 31.72 18.36 37 62299 157672 90408439
Odynophagia 31.69 18.36 35 62301 9008 90557103
Hair colour changes 31.36 18.36 23 62313 3471 90562640
Depressed level of consciousness 31.35 18.36 6 62330 72778 90493333
Electric shock sensation 30.94 18.36 17 62319 1553 90564558
Illness 30.88 18.36 9 62327 81960 90484151
Central nervous system lesion 30.75 18.36 39 62297 11607 90554504
Keratitis 30.71 18.36 24 62312 3982 90562129
Colitis ulcerative 30.59 18.36 3 62333 60263 90505848
Foot deformity 30.19 18.36 3 62333 59648 90506463
Oxygen saturation decreased 30.11 18.36 150 62186 107333 90458778
Sepsis 29.88 18.36 219 62117 179595 90386516
Pituitary tumour 29.86 18.36 14 62322 915 90565196
Pulmonary mass 29.76 18.36 63 62273 28709 90537402
Axillary pain 29.66 18.36 19 62317 2302 90563809
Urinary tract infection 29.60 18.36 331 62005 305301 90260810
Gastrointestinal disorder 29.49 18.36 85 62251 256602 90309509
Glossopharyngeal nerve paralysis 29.46 18.36 7 62329 49 90566062
Hallucination 29.35 18.36 5 62331 65954 90500157
Hepatic lesion 29.13 18.36 27 62309 5646 90560465
Osteosclerosis 29.11 18.36 24 62312 4296 90561815
Enterocolitis 29.09 18.36 36 62300 10454 90555657
Neurological decompensation 29.08 18.36 22 62314 3479 90562632
Neoplasm 28.71 18.36 33 62303 8870 90557241
Prescribed underdose 28.70 18.36 8 62328 75011 90491100
Invasive ductal breast carcinoma 28.69 18.36 31 62305 7787 90558324
Gastritis 28.67 18.36 78 62258 41675 90524436
Wound infection 28.59 18.36 19 62317 106383 90459728
B-cell type acute leukaemia 28.49 18.36 12 62324 607 90565504
Osteochondrosis 28.40 18.36 17 62319 1826 90564285
Dermatitis 28.20 18.36 53 62283 22167 90543944
Vascular fragility 28.13 18.36 9 62327 206 90565905
Soft tissue infection 28.12 18.36 20 62316 2877 90563234
Post-traumatic pain 27.72 18.36 11 62325 477 90565634
Secondary cerebellar degeneration 27.52 18.36 7 62329 67 90566044
Retracted nipple 27.49 18.36 6 62330 27 90566084
Dysuria 27.45 18.36 74 62262 39327 90526784
Incorrect dose administered 27.39 18.36 10 62326 78920 90487191
Pneumothorax 27.22 18.36 48 62288 19119 90546992
Paralysis recurrent laryngeal nerve 26.98 18.36 7 62329 73 90566038
Osteitis condensans 26.80 18.36 6 62330 31 90566080
Hyperkalaemia 26.65 18.36 6 62330 64958 90501153
Hyperproteinaemia 26.30 18.36 8 62328 154 90565957
Hepatic failure 26.08 18.36 73 62263 39655 90526456
Neoplasm recurrence 26.02 18.36 20 62316 3239 90562872
Gastroenteritis radiation 25.94 18.36 11 62325 566 90565545
Ascites 25.90 18.36 82 62254 47658 90518453
Mouth ulceration 25.79 18.36 73 62263 39901 90526210
Therapeutic response decreased 25.52 18.36 15 62321 89714 90476397
Electrocardiogram QT prolonged 25.45 18.36 9 62327 72447 90493664
Hair texture abnormal 25.42 18.36 23 62313 4664 90561447
Hiccups 25.10 18.36 19 62317 3007 90563104
Eastern Cooperative Oncology Group performance status worsened 25.09 18.36 16 62320 1923 90564188
Tachycardia 25.04 18.36 190 62146 157483 90408628
Tumour marker increased 24.85 18.36 25 62311 5782 90560329
Lymphangiosis carcinomatosa 24.68 18.36 15 62321 1657 90564454
White blood cell count abnormal 24.51 18.36 28 62308 7476 90558635
Autonomic neuropathy 24.19 18.36 14 62322 1413 90564698
Toxic cardiomyopathy 23.98 18.36 9 62327 335 90565776
Disease recurrence 23.56 18.36 68 62268 37585 90528526
Amnesia 23.42 18.36 24 62312 108481 90457630
Mean platelet volume decreased 23.32 18.36 18 62318 2932 90563179
Overflow diarrhoea 23.20 18.36 7 62329 131 90565980
Blepharospasm 22.99 18.36 5 62331 55440 90510671
Blood bilirubin increased 22.98 18.36 74 62262 43396 90522715
Bone marrow failure 22.94 18.36 61 62275 32160 90533951
Rash pustular 22.93 18.36 28 62308 8021 90558090
Palmar erythema 22.84 18.36 15 62321 1896 90564215
Vaginal prolapse 22.67 18.36 10 62326 567 90565544
Catheter site bruise 22.55 18.36 10 62326 574 90565537
Lung disorder 22.52 18.36 43 62293 149840 90416271
Duodenal ulcer 22.14 18.36 30 62306 9522 90556589
Dysentery 22.11 18.36 12 62324 1070 90565041
Peripheral sensorimotor neuropathy 21.91 18.36 15 62321 2030 90564081
Tongue coated 21.83 18.36 14 62322 1699 90564412
Aspartate aminotransferase increased 21.68 18.36 133 62203 102804 90463307
Erythema 21.60 18.36 247 62089 228999 90337112
Paraesthesia 21.52 18.36 265 62071 250061 90316050
Appendiceal abscess 21.47 18.36 8 62328 292 90565819
Ejection fraction abnormal 21.46 18.36 16 62320 2475 90563636
Liver injury 21.45 18.36 54 62282 170513 90395598
Tumour lysis syndrome 21.38 18.36 32 62304 11120 90554991
Night sweats 21.10 18.36 35 62301 128731 90437380
Eczema 21.06 18.36 82 62254 52788 90513323
Vulvovaginal candidiasis 20.88 18.36 19 62317 3881 90562230
Megacolon 20.84 18.36 15 62321 2199 90563912
Treatment noncompliance 20.78 18.36 5 62331 51722 90514389
Polyneuropathy chronic 20.74 18.36 4 62332 8 90566103
Vulvovaginal pain 20.74 18.36 18 62318 3456 90562655
Palpitations 20.73 18.36 163 62173 136565 90429546
Blood glucose increased 20.64 18.36 21 62315 95225 90470886
Hyperaemia 20.62 18.36 16 62320 2626 90563485
Ear pain 20.55 18.36 7 62329 57695 90508416
Hypocalcaemia 20.50 18.36 70 62266 42298 90523813
Cough 20.45 18.36 362 61974 368600 90197511
Blood lactate dehydrogenase increased 20.43 18.36 51 62285 25881 90540230
Osteolysis 20.40 18.36 18 62318 3532 90562579
Gingival pain 20.40 18.36 29 62307 9623 90556488
Catheter site pain 20.26 18.36 22 62314 5557 90560554
Dandy-Walker syndrome 20.10 18.36 6 62330 108 90566003
Embolism venous 20.10 18.36 18 62318 3602 90562509
Chronic obstructive pulmonary disease 20.08 18.36 13 62323 73816 90492295
Papilloedema 19.99 18.36 20 62316 4595 90561516
Mucosal disorder 19.95 18.36 16 62320 2755 90563356
Immunodeficiency 19.86 18.36 3 62333 43231 90522880
No adverse event 19.84 18.36 96 62240 67886 90498225
Therapy interrupted 19.82 18.36 5 62331 50103 90516008
Blood pressure systolic decreased 19.81 18.36 28 62308 9242 90556869
Back injury 19.75 18.36 4 62332 46618 90519493
Foetal exposure during pregnancy 19.70 18.36 3 62333 42972 90523139
Nail bed tenderness 19.67 18.36 8 62328 370 90565741
Naevus haemorrhage 19.56 18.36 6 62330 119 90565992
Skin infection 19.51 18.36 40 62296 17824 90548287
Haemorrhoids 19.46 18.36 51 62285 26651 90539460
Axillary vein thrombosis 19.43 18.36 8 62328 382 90565729
Vagus nerve disorder 19.28 18.36 6 62330 125 90565986
Metastases to breast 19.26 18.36 8 62328 391 90565720
Duodenal perforation 19.22 18.36 11 62325 1087 90565024
Nail disorder 19.14 18.36 86 62250 58981 90507130
Paraparesis 19.13 18.36 16 62320 2922 90563189
Lymphangiopathy 19.12 18.36 4 62332 14 90566097
Painful respiration 18.75 18.36 16 62320 3002 90563109
Flatulence 18.71 18.36 3 62333 41364 90524747
Breast operation 18.67 18.36 9 62327 626 90565485
Pain in extremity 18.65 18.36 209 62127 450320 90115791
Apical granuloma 18.63 18.36 5 62331 60 90566051
Chromosomal mutation 18.51 18.36 4 62332 17 90566094
Hypertensive crisis 18.46 18.36 39 62297 17745 90548366
Alanine aminotransferase increased 18.45 18.36 142 62194 118196 90447915
Rash follicular 18.41 18.36 5 62331 63 90566048
Hypersensitivity 18.40 18.36 212 62124 454465 90111646

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Delusion of grandeur 248.76 64.04 51 3034 1945 42616305
Rhinalgia 211.56 64.04 44 3041 1800 42616450
Affective disorder 207.70 64.04 54 3031 5906 42612344
Lymphocyte count abnormal 204.08 64.04 44 3041 2143 42616107
Schizophrenia 177.19 64.04 54 3031 10496 42607754
Extrapyramidal disorder 161.45 64.04 56 3029 16356 42601894
Hallucination, auditory 147.28 64.04 51 3034 14813 42603437
SARS-CoV-2 test positive 146.04 64.04 44 3041 8216 42610034
Disease progression 133.51 64.04 98 2987 143558 42474692
Neutrophil count increased 132.99 64.04 51 3034 19753 42598497
Psychotic disorder 123.53 64.04 54 3031 29154 42589096
Alopecia 120.17 64.04 53 3032 29223 42589027
Lymphocyte count decreased 119.51 64.04 52 3033 27757 42590493
Incorrect dose administered 109.37 64.04 60 3025 52914 42565336
Off label use 108.40 64.04 176 2909 638159 41980091
Mucosal inflammation 96.62 64.04 54 3031 49320 42568930
Dyspepsia 91.32 64.04 49 3036 41303 42576947
Cellulitis 83.05 64.04 53 3032 61532 42556718
Leukopenia 78.36 64.04 55 3030 74691 42543559
Neuropathy peripheral 75.74 64.04 61 3024 101792 42516458
Metastases to central nervous system 74.25 64.04 28 3057 10327 42607923
Seizure 68.76 64.04 62 3023 120499 42497751

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 3275.75 19.08 1374 55857 92966 110439102
Diarrhoea 1282.50 19.08 2180 55051 1137325 109394743
Ejection fraction decreased 896.79 19.08 433 56798 40447 110491621
Metastases to central nervous system 872.85 19.08 357 56874 22460 110509608
Disease progression 622.77 19.08 697 56534 243337 110288731
Neuropathy peripheral 620.71 19.08 603 56628 178674 110353394
Polyneuropathy 554.48 19.08 289 56942 31723 110500345
Mucosal inflammation 379.43 19.08 348 56883 95793 110436275
Neutropenia 325.99 19.08 645 56586 373975 110158093
Cardiotoxicity 279.71 19.08 148 57083 16733 110515335
Febrile neutropenia 278.57 19.08 548 56683 316219 110215849
Metastases to bone 262.31 19.08 177 57054 31195 110500873
Drug ineffective 257.44 19.08 246 56985 1520294 109011774
Chills 248.31 19.08 392 56839 190188 110341880
Left ventricular dysfunction 246.80 19.08 153 57078 23340 110508728
Vascular device infection 243.52 19.08 134 57097 16378 110515690
Metastases to liver 229.54 19.08 171 57060 35215 110496853
Metastases to lung 226.69 19.08 144 57087 22919 110509149
Palmar-plantar erythrodysaesthesia syndrome 215.57 19.08 175 57056 40850 110491218
Cardiac dysfunction 203.07 19.08 87 57144 6136 110525932
Metastases to lymph nodes 197.26 19.08 113 57118 14919 110517149
Peripheral sensory neuropathy 194.11 19.08 116 57115 16564 110515504
Nausea 183.09 19.08 1177 56054 1234513 109297555
Neutrophil count decreased 181.83 19.08 266 56965 120675 110411393
Neutropenic sepsis 169.70 19.08 135 57096 30611 110501457
Epistaxis 154.50 19.08 257 56974 130115 110401953
Interstitial lung disease 145.88 19.08 260 56971 139074 110392994
Off label use 145.30 19.08 1293 55938 1498892 109033176
Neoplasm progression 144.99 19.08 173 57058 64422 110467646
Breast cancer metastatic 141.24 19.08 82 57149 11099 110520969
Lymphoedema 141.22 19.08 91 57140 14838 110517230
Delusion of grandeur 138.96 19.08 50 57181 2210 110529858
Joint swelling 138.53 19.08 30 57201 442815 110089253
Hypokalaemia 135.85 19.08 295 56936 182153 110349915
Anaemia 135.39 19.08 601 56630 546485 109985583
Arthropathy 130.51 19.08 4 57227 287518 110244550
Paronychia 128.77 19.08 77 57154 11004 110521064
Dysgeusia 127.69 19.08 169 57062 69816 110462252
Confusional state 127.25 19.08 42 57189 468638 110063430
Pneumonitis 126.28 19.08 176 57055 76355 110455713
Fatigue 124.73 19.08 1062 56169 1214896 109317172
Cardiomyopathy 123.74 19.08 117 57114 33408 110498660
Platelet count decreased 123.49 19.08 328 56903 230115 110301953
Drug hypersensitivity 122.74 19.08 41 57190 454049 110078019
Product dose omission issue 118.06 19.08 14 57217 321768 110210300
Drug interaction 117.48 19.08 56 57175 500127 110031941
Condition aggravated 115.67 19.08 126 57105 734710 109797358
Bone pain 115.32 19.08 155 57076 64978 110467090
Abdominal discomfort 114.71 19.08 31 57200 393827 110138241
White blood cell count decreased 114.40 19.08 318 56913 229072 110302996
Erysipelas 114.20 19.08 76 57155 13082 110518986
Vomiting 113.89 19.08 833 56398 909842 109622226
Fall 113.28 19.08 88 57143 603394 109928674
Hyperpyrexia 112.18 19.08 63 57168 8006 110524062
Alopecia 110.82 19.08 427 56804 364326 110167742
Lymphocyte count abnormal 110.22 19.08 43 57188 2383 110529685
Nail dystrophy 109.97 19.08 36 57195 1192 110530876
Cellulitis 109.30 19.08 217 57014 125799 110406269
Mastitis 108.01 19.08 43 57188 2515 110529553
Nail toxicity 107.61 19.08 28 57203 402 110531666
Systemic lupus erythematosus 104.22 19.08 7 57224 254331 110277737
Therapeutic product effect decreased 102.28 19.08 6 57225 244310 110287758
Musculoskeletal stiffness 100.63 19.08 13 57218 279809 110252259
Cardiac failure 100.43 19.08 267 56964 187359 110344709
Pleural effusion 99.31 19.08 257 56974 177452 110354616
Mobility decreased 98.87 19.08 6 57225 237416 110294652
Radiation skin injury 96.20 19.08 35 57196 1597 110530471
Metastasis 94.90 19.08 57 57174 8210 110523858
Onycholysis 94.20 19.08 40 57191 2759 110529309
Product use in unapproved indication 90.76 19.08 60 57171 447317 110084751
Rhinalgia 90.26 19.08 43 57188 3886 110528182
Drug intolerance 88.76 19.08 50 57181 406462 110125606
Breast cancer recurrent 88.08 19.08 42 57189 3804 110528264
Metastases to skin 87.95 19.08 36 57195 2263 110529805
Skin toxicity 87.92 19.08 62 57169 11721 110520347
Hepatic function abnormal 87.54 19.08 162 57069 89133 110442935
Nail bed inflammation 85.28 19.08 34 57197 1996 110530072
Metastases to meninges 85.05 19.08 45 57186 5083 110526985
Pericarditis 84.28 19.08 8 57223 219106 110312962
Nail discolouration 84.17 19.08 40 57191 3595 110528473
Skin fissures 83.92 19.08 82 57149 24376 110507692
Toxicity to various agents 82.86 19.08 76 57155 480479 110051589
Granulocyte count decreased 80.78 19.08 40 57191 3934 110528134
Device related infection 79.22 19.08 100 57131 39419 110492649
Drug abuse 78.62 19.08 3 57228 177408 110354660
Breast pain 77.83 19.08 54 57177 9946 110522122
Mastectomy 76.57 19.08 29 57202 1482 110530586
Lacrimation increased 76.29 19.08 87 57144 30863 110501205
Injury 75.27 19.08 4 57227 177261 110354807
Osteoarthritis 74.88 19.08 5 57226 182618 110349450
Leukopenia 74.85 19.08 207 57024 148584 110383484
Inappropriate schedule of product administration 74.32 19.08 9 57222 203628 110328440
Impaired healing 73.53 19.08 8 57223 196709 110335359
Sinusitis 73.07 19.08 31 57200 296657 110235411
Dermatitis acneiform 72.75 19.08 57 57174 12638 110519430
Duodenal ulcer perforation 72.47 19.08 5 57226 177695 110354373
Hepatic enzyme increased 72.17 19.08 38 57193 320854 110211214
Affective disorder 69.94 19.08 53 57178 11188 110520880
Pain 67.70 19.08 260 56971 954695 109577373
HER2 positive breast cancer 67.41 19.08 19 57212 374 110531694
Decreased appetite 67.31 19.08 449 56782 475397 110056671
Asthma 66.87 19.08 23 57208 250268 110281800
Discomfort 66.16 19.08 15 57216 214692 110317376
Exposure during pregnancy 64.68 19.08 6 57225 167418 110364650
Recall phenomenon 64.33 19.08 25 57206 1371 110530697
Nasal mucosal disorder 63.67 19.08 27 57204 1856 110530212
Streptococcal sepsis 63.53 19.08 37 57194 5035 110527033
Tonsillar disorder 62.76 19.08 25 57206 1464 110530604
Thrombocytopenia 62.48 19.08 350 56881 348535 110183533
Pyrexia 61.78 19.08 723 56508 897542 109634526
Lymphocyte count decreased 61.38 19.08 108 57123 57135 110474933
Blood cholesterol increased 60.90 19.08 11 57220 184774 110347294
Stomatitis 60.81 19.08 289 56942 269953 110262115
Wheezing 60.74 19.08 28 57203 255202 110276866
Wound 60.16 19.08 23 57208 234414 110297654
Type 2 diabetes mellitus 59.62 19.08 10 57221 177222 110354846
Chest discomfort 58.95 19.08 211 57020 173637 110358431
Hyperkalaemia 57.85 19.08 3 57228 135793 110396275
Tumour pain 57.76 19.08 29 57202 2938 110529130
Swelling 57.58 19.08 58 57173 350983 110181085
Psoriasis 56.90 19.08 4 57227 139989 110392079
Bradycardia 56.43 19.08 7 57224 155510 110376558
Inflammation 54.74 19.08 16 57215 193222 110338846
Osteonecrosis of jaw 54.63 19.08 93 57138 47924 110484144
Folliculitis 53.09 19.08 11 57220 167642 110364426
Meibomian gland dysfunction 52.85 19.08 15 57216 303 110531765
Weight increased 52.59 19.08 85 57146 419559 110112509
Ventricular dysfunction 52.54 19.08 38 57193 7473 110524595
Urticaria 51.93 19.08 53 57178 318804 110213264
Irritable bowel syndrome 51.54 19.08 11 57220 164204 110367864
Pseudocirrhosis 51.46 19.08 19 57212 904 110531164
Glossodynia 50.33 19.08 26 57205 221978 110310090
Neutrophil count increased 50.28 19.08 75 57156 34577 110497491
Constipation 50.18 19.08 337 56894 357449 110174619
Sleep disorder 50.12 19.08 20 57211 198624 110333444
Somnolence 50.10 19.08 48 57183 297401 110234667
Injection site pain 49.91 19.08 15 57216 177907 110354161
Urinary tract infection 49.83 19.08 314 56917 325968 110206100
Cystitis noninfective 49.48 19.08 22 57209 1696 110530372
Gait disturbance 49.10 19.08 43 57188 278165 110253903
Hot flush 48.21 19.08 106 57125 65930 110466138
Depression 48.08 19.08 56 57175 317279 110214789
Madarosis 48.03 19.08 27 57204 3436 110528632
Sarcoid-like reaction 48.03 19.08 14 57217 312 110531756
Dehydration 47.77 19.08 277 56954 279234 110252834
Excessive eye blinking 47.70 19.08 22 57209 1848 110530220
Treatment failure 47.55 19.08 44 57187 277190 110254878
Obesity 46.77 19.08 3 57228 113348 110418720
Metastases to spine 46.70 19.08 31 57200 5312 110526756
Back pain 46.49 19.08 340 56891 370656 110161412
Product use issue 46.16 19.08 56 57175 311639 110220429
Aortitis 46.13 19.08 22 57209 1993 110530075
Cystitis haemorrhagic 45.79 19.08 43 57188 12166 110519902
Arthritis 45.45 19.08 15 57216 167571 110364497
Breast neoplasm 45.42 19.08 18 57213 1040 110531028
Vulvovaginal dryness 45.26 19.08 24 57207 2723 110529345
Onychalgia 44.16 19.08 18 57213 1119 110530949
Metastatic neoplasm 44.04 19.08 31 57200 5842 110526226
Malignant neoplasm progression 43.94 19.08 193 57038 174374 110357694
Depressed level of consciousness 43.43 19.08 4 57227 112274 110419794
Breast disorder 43.24 19.08 22 57209 2292 110529776
Gastrointestinal toxicity 43.23 19.08 40 57191 11108 110520960
Maternal exposure during pregnancy 43.07 19.08 41 57190 254842 110277226
Medication error 42.85 19.08 3 57228 105363 110426705
Feeling abnormal 42.72 19.08 20 57211 180691 110351377
Onychoclasis 42.56 19.08 33 57198 7204 110524864
Hyperfibrinogenaemia 41.76 19.08 11 57220 166 110531902
Varicose vein 41.59 19.08 32 57199 6908 110525160
Hemianopia 41.52 19.08 23 57208 2845 110529223
Osteosclerosis 41.42 19.08 27 57204 4488 110527580
Therapy partial responder 41.13 19.08 71 57160 36990 110495078
Microvascular coronary artery disease 40.90 19.08 13 57218 391 110531677
SARS-CoV-2 test positive 40.71 19.08 47 57184 16888 110515180
Delirium 40.47 19.08 10 57221 135015 110397053
Blister 40.29 19.08 35 57196 227341 110304727
Schizophrenia 40.24 19.08 53 57178 21773 110510295
Enterocolitis infectious 40.19 19.08 24 57207 3420 110528648
Hand dermatitis 40.19 19.08 15 57216 736 110531332
Central vision loss 40.18 19.08 9 57222 65 110532003
Hepatic lesion 39.96 19.08 34 57197 8459 110523609
Gastrointestinal haemorrhage 39.62 19.08 18 57213 165500 110366568
Alopecia areata 38.57 19.08 20 57211 2167 110529901
Myalgia 38.39 19.08 221 57010 222160 110309908
Hallucination 38.22 19.08 4 57227 101428 110430640
Nasal disorder 38.06 19.08 25 57206 4209 110527859
Therapeutic product effect incomplete 37.81 19.08 36 57195 223769 110308299
Pneumonitis chemical 37.76 19.08 14 57217 674 110531394
Contusion 37.74 19.08 39 57192 233322 110298746
Vessel puncture site bruise 37.63 19.08 13 57218 509 110531559
Dry skin 37.63 19.08 132 57099 107521 110424547
Blood magnesium decreased 37.56 19.08 49 57182 19947 110512121
Hypertransaminasaemia 37.36 19.08 54 57177 24201 110507867
Gait inability 37.34 19.08 12 57219 136364 110395704
Stress cardiomyopathy 36.55 19.08 43 57188 15763 110516305
Nail infection 36.15 19.08 20 57211 2468 110529600
Pseudomonal sepsis 36.14 19.08 33 57198 9013 110523055
Anxiety 36.06 19.08 78 57153 345000 110187068
Hyperchlorhydria 35.87 19.08 19 57212 2150 110529918
Biliary sepsis 35.84 19.08 18 57213 1825 110530243
Neurotoxicity 35.75 19.08 72 57159 42135 110489933
Carbohydrate antigen 15-3 increased 35.34 19.08 17 57214 1570 110530498
Myocardial infarction 34.72 19.08 29 57202 192054 110340014
Hair texture abnormal 34.70 19.08 23 57208 3931 110528137
Suicidal ideation 34.64 19.08 4 57227 93933 110438135
Folate deficiency 34.62 19.08 24 57207 4414 110527654
Nasal congestion 34.28 19.08 5 57226 98277 110433791
Flushing 33.70 19.08 125 57106 104611 110427457
Hospitalisation 33.32 19.08 16 57215 142477 110389591
White blood cell count abnormal 33.21 19.08 28 57203 6881 110525187
Mucosal dryness 33.13 19.08 23 57208 4240 110527828
Red cell distribution width increased 32.85 19.08 43 57188 17559 110514509
Musculoskeletal pain 32.63 19.08 28 57203 182995 110349073
Injection site reaction 32.33 19.08 4 57227 89066 110443002
Invasive ductal breast carcinoma 32.08 19.08 27 57204 6619 110525449
Cardio-respiratory arrest 32.06 19.08 10 57221 115826 110416242
Nodular regenerative hyperplasia 31.92 19.08 16 57215 1615 110530453
Extrapyramidal disorder 31.64 19.08 55 57176 28812 110503256
Paraesthesia 31.57 19.08 248 56983 276273 110255795
Keratitis 31.44 19.08 24 57207 5120 110526948
Metastases to pleura 31.12 19.08 17 57214 2046 110530022
Hair colour changes 31.11 19.08 23 57208 4678 110527390
Electrocardiogram QT prolonged 30.89 19.08 9 57222 108951 110423117
Adverse event 30.83 19.08 9 57222 108800 110423268
Cerebrovascular accident 30.81 19.08 29 57202 181255 110350813
Arthralgia 30.74 19.08 257 56974 779375 109752693
Acute interstitial pneumonitis 30.72 19.08 15 57216 1431 110530637
Hepatotoxicity 30.68 19.08 87 57144 63313 110468755
Therapy non-responder 30.65 19.08 22 57209 157285 110374783
Central nervous system lesion 30.60 19.08 39 57192 15514 110516554
Vascular fragility 30.49 19.08 9 57222 210 110531858
Dyspnoea 30.35 19.08 768 56463 1106104 109425964
Neck pain 30.08 19.08 13 57218 123117 110408951
Drug ineffective for unapproved indication 30.08 19.08 8 57223 102830 110429238
Post-traumatic pain 29.86 19.08 11 57220 520 110531548
Glossopharyngeal nerve paralysis 29.59 19.08 7 57224 66 110532002
Colitis 29.54 19.08 118 57113 102205 110429863
Coma 29.51 19.08 12 57219 117857 110414211
Metastases to bone marrow 29.25 19.08 13 57218 1001 110531067
Vulvovaginal candidiasis 28.57 19.08 19 57212 3266 110528802
Hallucination, auditory 28.55 19.08 50 57181 26347 110505721
Congestive cardiomyopathy 28.52 19.08 36 57195 14183 110517885
Osteitis condensans 28.50 19.08 6 57225 31 110532037
Intracranial pressure increased 28.34 19.08 31 57200 10504 110521564
Anaphylactic shock 28.20 19.08 74 57157 51472 110480596
Nail bed bleeding 28.03 19.08 12 57219 844 110531224
Dyspepsia 28.02 19.08 182 57049 190783 110341285
Osteochondrosis 27.95 19.08 17 57214 2504 110529564
Blood creatine increased 27.74 19.08 32 57199 11489 110520579
Breast inflammation 27.59 19.08 8 57223 175 110531893
Axillary pain 27.55 19.08 17 57214 2569 110529499
Gastritis 27.27 19.08 75 57156 53624 110478444
Odynophagia 27.18 19.08 35 57196 14066 110518002
Product quality issue 26.80 19.08 4 57227 77295 110454773
Pituitary tumour 26.63 19.08 13 57218 1240 110530828
Memory impairment 26.47 19.08 38 57193 196906 110335162
Seroma 26.10 19.08 18 57213 3283 110528785
Agitation 25.97 19.08 13 57218 113038 110419030
Rhabdomyolysis 25.97 19.08 15 57216 120386 110411682
Pulmonary hypoplasia 25.82 19.08 6 57225 52 110532016
Papilloedema 25.71 19.08 25 57206 7384 110524684
Lymphadenopathy 25.61 19.08 82 57149 63753 110468315
Recurrent cancer 25.51 19.08 18 57213 3405 110528663
Haematochezia 25.48 19.08 14 57217 115510 110416558
Gastroenteritis radiation 25.39 19.08 11 57220 797 110531271
Agranulocytosis 25.38 19.08 80 57151 61680 110470388
Tumour marker increased 25.34 19.08 21 57210 5039 110527029
Vaginal prolapse 25.29 19.08 9 57222 385 110531683
Migraine 25.23 19.08 31 57200 171621 110360447
Blood glucose increased 25.21 19.08 19 57212 132477 110399591
Catheter site bruise 25.18 19.08 10 57221 581 110531487
Osteoporosis 25.07 19.08 7 57224 87145 110444923
Lung disorder 24.93 19.08 34 57197 180013 110352055
Mitral valve incompetence 24.89 19.08 54 57177 33275 110498793
Bone marrow infiltration 24.63 19.08 11 57220 857 110531211
Tongue coated 24.20 19.08 14 57217 1882 110530186
Haemoptysis 24.05 19.08 4 57227 71350 110460718
Orthostatic hypotension 23.99 19.08 3 57228 66246 110465822
Palmar erythema 23.97 19.08 15 57216 2323 110529745
Brain oedema 23.93 19.08 51 57180 31047 110501021
Electric shock sensation 23.87 19.08 14 57217 1930 110530138
Sciatica 23.80 19.08 9 57222 92390 110439678
Mean platelet volume decreased 23.78 19.08 17 57214 3283 110528785
Renal impairment 23.74 19.08 38 57193 188407 110343661
Nasal discomfort 23.62 19.08 22 57209 6159 110525909
Haemorrhoids 23.52 19.08 55 57176 35617 110496451
Hyperproteinaemia 23.19 19.08 8 57223 312 110531756
Soft tissue infection 23.12 19.08 20 57211 5087 110526981
Tidal volume decreased 23.07 19.08 6 57225 86 110531982
Adverse drug reaction 22.98 19.08 13 57218 105546 110426522
Chronic obstructive pulmonary disease 22.98 19.08 14 57217 109144 110422924
Pulmonary mass 22.96 19.08 56 57175 37245 110494823
Illness 22.91 19.08 7 57224 82164 110449904
Hypomagnesaemia 22.82 19.08 76 57155 60294 110471774
Treatment noncompliance 22.67 19.08 5 57226 72985 110459083
Dysentery 22.65 19.08 12 57219 1359 110530709
Polyneuropathy chronic 22.33 19.08 5 57226 36 110532032
Ear infection 22.33 19.08 3 57228 62729 110469339
Peripheral swelling 21.98 19.08 121 57110 403913 110128155
B-cell type acute leukaemia 21.91 19.08 12 57219 1452 110530616
Nail bed tenderness 21.76 19.08 8 57223 376 110531692
Overflow diarrhoea 21.73 19.08 7 57224 220 110531848
Dental fistula 21.70 19.08 9 57222 585 110531483
Paralysis recurrent laryngeal nerve 21.52 19.08 7 57224 227 110531841
Systolic dysfunction 21.44 19.08 18 57213 4397 110527671
Naevus haemorrhage 21.25 19.08 6 57225 119 110531949
Spinal pain 21.24 19.08 36 57195 18479 110513589
Swollen tongue 21.22 19.08 3 57228 60359 110471709
Nail disorder 21.08 19.08 72 57159 57863 110474205
Appendiceal abscess 20.97 19.08 8 57223 417 110531651
Breast cancer 20.74 19.08 55 57176 38487 110493581
Lymphangiosis carcinomatosa 20.73 19.08 14 57217 2468 110529600
Dandy-Walker syndrome 20.69 19.08 5 57226 52 110532016
Metastases to chest wall 20.58 19.08 9 57222 667 110531401
Mouth ulceration 20.38 19.08 63 57168 48075 110483993
Seizure 20.29 19.08 189 57042 220996 110311072
Cardiac arrest 20.11 19.08 45 57186 196708 110335360
Eosinophilia 20.08 19.08 3 57228 57933 110474135
Metastases to soft tissue 20.05 19.08 9 57222 710 110531358
Osteolysis 19.85 19.08 19 57212 5504 110526564
Neurological decompensation 19.82 19.08 21 57210 6862 110525206
Skin infection 19.78 19.08 39 57192 22470 110509598
Oxygen saturation decreased 19.70 19.08 144 57087 156838 110375230
Dermatitis 19.54 19.08 44 57187 27793 110504275
Perforation 19.54 19.08 12 57219 1798 110530270
Apical granuloma 19.53 19.08 5 57226 67 110532001
Brain neoplasm 19.44 19.08 20 57211 6317 110525751
Wound infection 19.44 19.08 13 57218 96452 110435616

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FD02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
ATC L01FY01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
Combinations of monoclonal antibodies and antibody drug conjugates
FDA MoA N0000020008 HER2/Neu/cerbB2 Antagonists
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000970 Antineoplastic Agents
FDA EPC N0000175661 HER2/neu Receptor Antagonist
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

L01FD HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors 5 drugs
margetuximabtrastuzumabtrastuzumab deruxtecantrastuzumab emtansinezanidatamab-hrii
L01FY Combinations of monoclonal antibodies and antibody drug conjugates 3 drugs
nivolumabrelatlimabtrastuzumab

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
HER2-positive rectal cancer indication 363351006 DOID:1993
HER2-positive colon cancer indication 363406005 DOID:219
HER2-positive carcinoma of breast indication 427685000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Receptor tyrosine-protein kinase erbB-2 Kinase ANTIBODY BINDING UNKNOWN DRUG LABEL

External reference:

IDSource
D05446 KEGG_DRUG
4031566 VUID
N0000185031 NUI
4031566 VANDF
CHEBI:750362 CHEBI
CHEMBL2007641 ChEMBL_ID
C485206 MESH_SUPPLEMENTAL_RECORD_UI
5046 IUPHAR_LIGAND_ID
DB06366 DRUGBANK_ID
1298944 RXNORM
190566 MMSL
28589 MMSL
d07874 MMSL
014427 NDDF
704226002 SNOMEDCT_US
704227006 SNOMEDCT_US
C1328025 UMLSCUI
8380 INN_ID
K16AIQ8CTM UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PERJETA HUMAN PRESCRIPTION DRUG LABEL 1 50242-145 INJECTION, SOLUTION, CONCENTRATE 30 mg INTRAVENOUS BLA 29 sections
Phesgo HUMAN PRESCRIPTION DRUG LABEL 3 50242-245 INJECTION, SOLUTION 1200 mg SUBCUTANEOUS BLA 30 sections
Phesgo HUMAN PRESCRIPTION DRUG LABEL 3 50242-260 INJECTION, SOLUTION 600 mg SUBCUTANEOUS BLA 30 sections