bevacizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4956 216974-75-3

Description:

MoleculeDescription

Synonyms:

  • bevacizumab-awwb
  • mvasi
  • bevacizumab
  • avastin
  • rhuMAb-VEGF
  • bevacituzumab
  • bevacizumab (genetical recombination)
  • bevacizumab biosimilar 3
  • bevacizumab biosimilar 4
An anti-VEGF humanized murine monoclonal antibody. It inhibits VEGF RECEPTORS and helps to prevent PATHOLOGIC ANGIOGENESIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 1, 2005 EMA Roche Registration Limited
Feb. 26, 2004 FDA GENENTECH
April 18, 2007 PMDA Chugai Pharmaceutical

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 3230.42 13.59 2341 122876 120417 63243388
Death 3050.03 13.59 3708 121509 370673 62993132
Proteinuria 1597.63 13.59 772 124445 18373 63345432
Gastrointestinal perforation 1151.55 13.59 380 124837 3111 63360694
Hypertension 1110.95 13.59 1979 123238 277324 63086481
Off label use 900.39 13.59 3140 122077 671322 62692483
Endophthalmitis 853.74 13.59 306 124911 3286 63360519
Malignant neoplasm progression 788.80 13.59 889 124328 81232 63282573
Neutrophil count decreased 776.95 13.59 741 124476 55665 63308140
Palmar-plantar erythrodysaesthesia syndrome 743.46 13.59 499 124718 22516 63341289
Myelosuppression 708.85 13.59 490 124727 23213 63340592
Neutropenia 677.52 13.59 1227 123990 173778 63190027
Intestinal perforation 607.17 13.59 346 124871 11617 63352188
Anaemia 588.63 13.59 1579 123638 291851 63071954
Epistaxis 573.50 13.59 712 124505 72013 63291792
Neuropathy peripheral 536.97 13.59 871 124346 112796 63251009
Ascites 524.85 13.59 516 124701 40212 63323593
Metastases to liver 517.67 13.59 405 124812 23234 63340571
Joint swelling 504.90 13.59 37 125180 327629 63036176
Bone marrow failure 501.57 13.59 435 124782 28855 63334950
Mucosal inflammation 489.96 13.59 531 124686 46397 63317408
Large intestine perforation 475.79 13.59 262 124955 8220 63355585
Rheumatoid arthritis 441.09 13.59 13 125204 253806 63109999
Drug ineffective 434.91 13.59 883 124334 1043882 62319923
Febrile neutropenia 424.61 13.59 804 124413 117645 63246160
Arthropathy 411.75 13.59 11 125206 234781 63129024
Posterior reversible encephalopathy syndrome 407.78 13.59 310 124907 17035 63346770
Contraindicated product administered 398.35 13.59 6 125211 217642 63146163
Thrombocytopenia 387.34 13.59 894 124323 150263 63213542
Systemic lupus erythematosus 381.33 13.59 6 125211 208912 63154893
Metastases to lung 377.40 13.59 262 124955 12488 63351317
Maternal exposure during pregnancy 369.25 13.59 15 125202 220047 63143758
Suspected transmission of an infectious agent via product 362.24 13.59 90 125127 212 63363593
Platelet count decreased 359.14 13.59 741 124476 115381 63248424
Synovitis 351.75 13.59 3 125214 186915 63176890
Peripheral sensory neuropathy 334.38 13.59 199 125018 7252 63356553
Metastases to bone 319.73 13.59 292 124925 20727 63343078
Peritonitis 296.11 13.59 256 124961 16898 63346907
Therapeutic product effect decreased 293.96 13.59 23 125194 193164 63170641
Intestinal obstruction 281.92 13.59 326 124891 30573 63333232
Metastases to central nervous system 279.26 13.59 221 124996 12884 63350921
Glossodynia 272.98 13.59 21 125196 178855 63184950
Swelling 271.32 13.59 102 125115 275276 63088529
Completed suicide 266.53 13.59 4 125213 145669 63218136
Peripheral swelling 264.53 13.59 97 125120 265845 63097960
Neurotoxicity 262.27 13.59 238 124979 16752 63347053
Small intestinal obstruction 258.15 13.59 244 124973 18093 63345712
Exposure during pregnancy 256.23 13.59 12 125205 155535 63208270
Product dose omission issue 253.18 13.59 74 125143 234239 63129566
Visual acuity reduced 247.23 13.59 258 124959 21568 63342237
Condition aggravated 243.27 13.59 261 124956 401956 62961849
White blood cell count decreased 242.13 13.59 712 124505 138392 63225413
Polyneuropathy 240.30 13.59 212 125005 14377 63349428
Drug intolerance 239.82 13.59 157 125060 308504 63055301
Pulmonary embolism 237.25 13.59 632 124585 116052 63247753
Abdominal discomfort 236.34 13.59 173 125044 320712 63043093
Drug hypersensitivity 229.46 13.59 167 125050 310520 63053285
Detachment of retinal pigment epithelium 227.63 13.59 66 125151 330 63363475
Age-related macular degeneration 227.62 13.59 76 125141 647 63363158
Abdominal pain 227.34 13.59 1161 124056 292295 63071510
Sinusitis 224.80 13.59 83 125134 226570 63137235
Arthralgia 223.61 13.59 496 124721 569214 62794591
Musculoskeletal stiffness 223.35 13.59 46 125171 184572 63179233
Osteonecrosis of jaw 222.55 13.59 309 124908 34814 63328991
Pain 221.65 13.59 737 124480 739891 62623914
Macular oedema 218.09 13.59 120 125097 3757 63360048
Pleural effusion 215.50 13.59 530 124687 92680 63271125
Ileus 213.15 13.59 199 125018 14526 63349279
Drug interaction 212.40 13.59 93 125124 229038 63134767
Metastases to peritoneum 211.61 13.59 113 125104 3329 63360476
Neoplasm progression 210.93 13.59 307 124910 36121 63327684
Leukopenia 210.93 13.59 469 124748 76821 63286984
Small intestinal perforation 202.60 13.59 85 125132 1430 63362375
Hepatic enzyme increased 194.13 13.59 78 125139 202250 63161555
Embolism 194 13.59 145 125072 7761 63356044
Vomiting 192.54 13.59 1813 123404 557804 62806001
Metastases to meninges 190.34 13.59 96 125121 2506 63361299
Treatment failure 185.70 13.59 80 125137 198963 63164842
Dehydration 185.70 13.59 755 124462 172599 63191206
Weight increased 185.04 13.59 146 125071 260646 63103159
Blindness 183.10 13.59 220 124997 21479 63342326
Diarrhoea 181.81 13.59 2180 123037 713186 62650619
Wound 181.04 13.59 49 125168 163214 63200591
Ovarian cancer recurrent 180.70 13.59 70 125147 947 63362858
Pericarditis 178.59 13.59 24 125193 131555 63232250
Retinal haemorrhage 178.04 13.59 115 125102 4854 63358951
Injection site pain 177.79 13.59 23 125194 129777 63234028
Decreased appetite 174.96 13.59 965 124252 250087 63113718
No adverse event 174.83 13.59 302 124915 41103 63322702
Tumour necrosis 173.11 13.59 64 125153 755 63363050
Vitreous floaters 172.81 13.59 121 125096 5845 63357960
Wound dehiscence 169.61 13.59 111 125106 4792 63359013
Pruritus 168.24 13.59 284 124933 361169 63002636
Female genital tract fistula 164.33 13.59 129 125088 7430 63356375
Helicobacter infection 163.83 13.59 4 125213 92781 63271024
Nephrotic syndrome 163.63 13.59 114 125103 5462 63358343
Thrombotic microangiopathy 163.10 13.59 148 125069 10413 63353392
Asthma 162.31 13.59 28 125189 127533 63236272
Haematotoxicity 161.95 13.59 140 125077 9236 63354569
Nausea 160.88 13.59 2467 122750 852004 62511801
Protein urine 158.31 13.59 59 125158 713 63363092
Photopsia 158.22 13.59 103 125114 4406 63359399
Pneumothorax 155.80 13.59 176 125041 16085 63347720
Psoriasis 152.58 13.59 4 125213 86953 63276852
Lower respiratory tract infection 151.87 13.59 37 125180 132270 63231535
Cystoid macular oedema 151.18 13.59 70 125147 1505 63362300
General physical health deterioration 146.20 13.59 783 124434 200619 63163186
Rectal perforation 144.97 13.59 48 125169 397 63363408
Hepatic atrophy 144.37 13.59 43 125174 240 63363565
Discomfort 141.28 13.59 77 125140 167297 63196508
Hydronephrosis 140.84 13.59 137 125080 10525 63353280
Eye discharge 139.48 13.59 107 125110 5956 63357849
Blister 138.29 13.59 42 125175 129772 63234033
Nasal septum perforation 137.76 13.59 53 125164 703 63363102
Rash 137.11 13.59 605 124612 560266 62803539
Blood cholesterol increased 135.40 13.59 14 125203 94018 63269787
Eye haemorrhage 135.02 13.59 121 125096 8375 63355430
Nasopharyngitis 134.40 13.59 183 125034 254074 63109731
Glomerular vascular disorder 133.79 13.59 30 125187 35 63363770
Injection site erythema 131.97 13.59 8 125209 83166 63280639
Fistula 128.84 13.59 129 125088 10264 63353541
Fall 127.06 13.59 376 124841 391958 62971847
Hepatic failure 125.05 13.59 240 124977 35416 63328389
Irritable bowel syndrome 124.75 13.59 10 125207 82402 63281403
Fibromyalgia 123.88 13.59 9 125208 80411 63283394
Carbohydrate antigen 125 increased 123.20 13.59 74 125143 2742 63361063
Retinal pigment epithelial tear 121.98 13.59 37 125180 222 63363583
Mobility decreased 120.66 13.59 44 125173 121115 63242690
Loss of personal independence in daily activities 120.20 13.59 23 125194 97267 63266538
Duodenal ulcer perforation 118.10 13.59 16 125201 87193 63276612
Urticaria 117.29 13.59 93 125124 165709 63198096
Portal hypertension 116.58 13.59 80 125137 3739 63360066
Deep vein thrombosis 115.51 13.59 396 124821 83404 63280401
Bacterial endophthalmitis 115.51 13.59 30 125187 90 63363715
Constipation 113.46 13.59 796 124421 224147 63139658
Subileus 112.48 13.59 73 125144 3106 63360699
Metastasis 111.48 13.59 88 125129 5109 63358696
Tumour haemorrhage 110.09 13.59 57 125160 1574 63362231
Hospitalisation 107.50 13.59 19 125198 85062 63278743
Protein urine present 106.95 13.59 92 125125 6028 63357777
Therapy partial responder 103.20 13.59 116 125101 10542 63353263
Overdose 102.98 13.59 49 125168 115029 63248776
Arthritis 102.75 13.59 50 125167 115871 63247934
Feeling abnormal 102.75 13.59 85 125132 148307 63215498
Injury 102.68 13.59 12 125205 73235 63290570
Metastases to lymph nodes 102.49 13.59 102 125115 8056 63355749
Dysphonia 101.87 13.59 263 124954 47351 63316454
Insomnia 98.30 13.59 171 125046 215081 63148724
Carcinoembryonic antigen increased 97.54 13.59 54 125163 1711 63362094
Malignant pleural effusion 95.06 13.59 61 125156 2545 63361260
Hypertensive crisis 94.59 13.59 133 125084 15153 63348652
Toxicity to various agents 93.62 13.59 219 124998 247031 63116774
Suicidal ideation 93.29 13.59 8 125209 62413 63301392
Urogenital fistula 92.03 13.59 29 125188 201 63363604
Vitritis 91.84 13.59 43 125174 949 63362856
Gastric perforation 91.78 13.59 51 125166 1628 63362177
Folliculitis 90.38 13.59 15 125202 70302 63293503
Uveitis 87.95 13.59 116 125101 12437 63351368
Contusion 87.59 13.59 100 125117 149944 63213861
Inappropriate schedule of product administration 87.45 13.59 48 125169 103917 63259888
COVID-19 87.05 13.59 58 125159 113045 63250760
Dizziness 87.00 13.59 495 124722 429430 62934375
Hepatic function abnormal 86.61 13.59 212 125005 36930 63326875
Osteoarthritis 86.22 13.59 40 125177 95303 63268502
Aortic dissection 85.63 13.59 52 125165 1966 63361839
Vitreous detachment 85.41 13.59 52 125165 1975 63361830
Ejection fraction decreased 85.38 13.59 156 125061 22176 63341629
Metamorphopsia 85.33 13.59 43 125174 1120 63362685
Intentional product misuse 85.33 13.59 10 125207 60907 63302898
Wheezing 85.07 13.59 41 125176 95554 63268251
Oesophagitis 84.71 13.59 125 125092 14883 63348922
Influenza 83.34 13.59 56 125161 108666 63255139
Intentional product use issue 83.23 13.59 483 124734 127409 63236396
Gastrointestinal toxicity 83.19 13.59 89 125128 7652 63356153
Suicide attempt 82.90 13.59 11 125206 60907 63302898
Retinal oedema 82.73 13.59 36 125181 665 63363140
Pseudocirrhosis 82.44 13.59 36 125181 671 63363134
Asthenia 82.09 13.59 1134 124083 382470 62981335
Duodenal perforation 81.56 13.59 38 125179 829 63362976
Dermatitis acneiform 81.07 13.59 72 125145 4924 63358881
Infusion related reaction 81.04 13.59 233 124984 245288 63118517
Osteonecrosis 81.01 13.59 161 125056 24369 63339436
Depression 80.99 13.59 166 125051 196326 63167479
Myelodysplastic syndrome 79.78 13.59 129 125088 16625 63347180
Injection site reaction 78.61 13.59 11 125206 58513 63305292
Somnolence 77.05 13.59 147 125070 178538 63185267
Hypomagnesaemia 76.79 13.59 173 125044 28564 63335241
Cataract nuclear 76.19 13.59 37 125180 888 63362917
Bronchitis 75.40 13.59 81 125136 124854 63238951
Cerebral ischaemia 75.22 13.59 79 125138 6649 63357156
Gait disturbance 74.44 13.59 156 125061 183022 63180783
Hepatitis B reactivation 73.56 13.59 56 125161 3081 63360724
Pain in extremity 73.47 13.59 370 124847 331116 63032689
Enterocutaneous fistula 72.46 13.59 41 125176 1356 63362449
Left ventricular dysfunction 70.78 13.59 102 125115 11886 63351919
Red blood cell sedimentation rate increased 70.47 13.59 4 125213 43978 63319827
Injection site pruritus 69.61 13.59 5 125212 45111 63318694
Type 2 diabetes mellitus 69.20 13.59 20 125197 63848 63299957
Tumour perforation 68.98 13.59 20 125197 100 63363705
Skin toxicity 68.78 13.59 64 125153 4650 63359155
Tumour marker increased 68.40 13.59 65 125152 4850 63358955
Adverse drug reaction 68.21 13.59 36 125181 79678 63284127
Interstitial lung disease 67.25 13.59 271 124946 61637 63302168
Metastases to pleura 65.10 13.59 40 125177 1545 63362260
Malignant ascites 65.02 13.59 33 125184 873 63362932
Stress 64.18 13.59 26 125191 67141 63296664
Illness 64.09 13.59 10 125207 49049 63314756
Osteoporosis 63.91 13.59 17 125200 57321 63306484
Hypokalaemia 63.64 13.59 386 124831 103418 63260387
Retinal exudates 63.10 13.59 30 125187 686 63363119
Visual impairment 63.00 13.59 331 124886 84115 63279690
Eastern Cooperative Oncology Group performance status worsened 62.89 13.59 36 125181 1218 63362587
Disseminated intravascular coagulation 62.86 13.59 125 125092 18926 63344879
Neoplasm 62.82 13.59 75 125142 7270 63356535
Vitreous haemorrhage 62.71 13.59 43 125174 2007 63361798
Migraine 62.36 13.59 67 125150 103279 63260526
Perforation 62.12 13.59 35 125182 1148 63362657
Subretinal fluid 62.04 13.59 26 125191 436 63363369
Anastomotic leak 61.24 13.59 26 125191 451 63363354
Dry throat 61.05 13.59 71 125146 6694 63357111
Lymphangiosis carcinomatosa 60.71 13.59 37 125180 1408 63362397
Therapeutic product effect incomplete 60.15 13.59 96 125121 124960 63238845
Sepsis 59.93 13.59 511 124706 152612 63211193
Eye pruritus 59.80 13.59 121 125096 18550 63345255
Acute myeloid leukaemia 59.60 13.59 115 125102 17032 63346773
Lymphocele 59.34 13.59 30 125187 787 63363018
Leukoencephalopathy 58.83 13.59 57 125160 4356 63359449
Cardiomyopathy 58.77 13.59 116 125101 17468 63346337
Abortion spontaneous 58.62 13.59 11 125206 47184 63316621
Hypersensitivity 58.57 13.59 338 124879 292347 63071458
Product use issue 57.92 13.59 231 124986 220289 63143516
Haemoptysis 57.69 13.59 155 125062 28571 63335234
Hypophosphataemia 57.18 13.59 90 125127 11336 63352469
Enteritis 57.17 13.59 76 125141 8210 63355595
Ovarian cancer metastatic 56.69 13.59 30 125187 867 63362938
Wrong technique in product usage process 56.59 13.59 26 125191 62314 63301491
Haemoglobin 56.57 13.59 19 125198 165 63363640
Transmission of an infectious agent via product 56.13 13.59 18 125199 133 63363672
Throat tightness 55.85 13.59 140 125077 24747 63339058
Pneumonitis 55.28 13.59 174 125043 35048 63328757
Pyrexia 54.76 13.59 1263 123954 469215 62894590
Superior vena cava syndrome 54.70 13.59 27 125190 672 63363133
Cholangitis 54.65 13.59 61 125156 5500 63358305
Incorrect dose administered 54.45 13.59 25 125192 59943 63303862
Adverse event 54.23 13.59 33 125184 67526 63296279
Venous thrombosis limb 54.16 13.59 46 125171 2962 63360843
Laryngospasm 53.89 13.59 46 125171 2982 63360823
Macular ischaemia 53.77 13.59 13 125204 26 63363779
Injection site bruising 53.72 13.59 9 125208 41901 63321904
Pneumonia 53.37 13.59 610 124607 456157 62907648
Mucosal toxicity 53.16 13.59 22 125195 357 63363448
Eye inflammation 52.61 13.59 60 125157 5539 63358266
Ileal perforation 52.56 13.59 23 125194 431 63363374
Sleep disorder 52.49 13.59 50 125167 81516 63282289
Palpitations 51.97 13.59 89 125128 112681 63251124
Ear infection 51.75 13.59 7 125210 38206 63325599
Headache 51.29 13.59 910 124307 632331 62731474
Retinal disorder 50.64 13.59 35 125182 1655 63362150
Tumour ulceration 50.48 13.59 18 125199 190 63363615
Peritoneal disorder 50.34 13.59 23 125194 479 63363326
Anxiety 49.77 13.59 240 124977 217301 63146504
Paronychia 49.54 13.59 58 125159 5507 63358298
Retinal detachment 49.50 13.59 60 125157 5909 63357896
Laryngeal necrosis 49.45 13.59 11 125206 12 63363793
Electrocardiogram QT prolonged 49.30 13.59 28 125189 59502 63304303
Large intestinal obstruction 49.17 13.59 39 125178 2280 63361525
Metastatic neoplasm 49.03 13.59 51 125166 4244 63359561
Device related infection 48.78 13.59 128 125089 23264 63340541
Abdominal abscess 48.57 13.59 52 125165 4474 63359331
Gastrointestinal fistula 48.29 13.59 22 125195 455 63363350
Ciliary hyperaemia 48.26 13.59 10 125207 5 63363800
C-reactive protein increased 48.14 13.59 70 125147 94637 63269168
Muscle spasms 48.03 13.59 153 125064 155997 63207808
Lymphocyte count decreased 47.97 13.59 150 125067 30107 63333698
Pantoea agglomerans infection 47.79 13.59 12 125205 30 63363775
Memory impairment 47.39 13.59 83 125134 104175 63259630
Chronic obstructive pulmonary disease 47.08 13.59 33 125184 62653 63301152
Venous thrombosis 46.85 13.59 53 125164 4849 63358956
Haematuria 46.64 13.59 145 125072 29012 63334793
Drug reaction with eosinophilia and systemic symptoms 46.30 13.59 6 125211 33830 63329975
Sedation 46.21 13.59 10 125207 38799 63325006
Suspected counterfeit product 45.89 13.59 20 125197 371 63363434
Retinal degeneration 45.87 13.59 26 125191 863 63362942
Acute abdomen 45.78 13.59 32 125185 1541 63362264
Treatment noncompliance 45.72 13.59 9 125208 37316 63326489
Hemiparesis 45.13 13.59 124 125093 23158 63340647
Immune thrombocytopenia 44.54 13.59 77 125140 10479 63353326
Bladder tamponade 44.35 13.59 13 125204 68 63363737
Anal fistula 43.87 13.59 44 125173 3507 63360298
Therapy interrupted 43.82 13.59 6 125211 32449 63331356
Gastric disorder 43.74 13.59 10 125207 37359 63326446
Pulmonary haemorrhage 43.72 13.59 62 125155 7119 63356686
Pelvic abscess 43.58 13.59 32 125185 1666 63362139
Retinal vascular disorder 43.56 13.59 16 125201 185 63363620
Hypoalbuminaemia 43.28 13.59 81 125136 11724 63352081
Plasma cell myeloma 43.26 13.59 9 125208 35896 63327909
Stomatitis 43.23 13.59 441 124776 138284 63225521
Foot deformity 43.22 13.59 3 125214 27850 63335955
Metastases to ovary 42.85 13.59 20 125197 438 63363367
Cardiac failure 42.85 13.59 312 124905 88830 63274975
Fluid retention 42.78 13.59 33 125184 59653 63304152
Therapy cessation 42.65 13.59 5 125212 30452 63333353
Neutropenic infection 42.59 13.59 29 125188 1338 63362467
Irritability 42.46 13.59 6 125211 31688 63332117
Radiation necrosis 42.06 13.59 19 125198 385 63363420
Joint stiffness 42.01 13.59 15 125202 41854 63321951
Tumour rupture 41.76 13.59 15 125202 162 63363643
Colitis 41.69 13.59 198 125019 48330 63315475
Joint range of motion decreased 41.48 13.59 7 125210 32421 63331384
Lactic acidosis 41.46 13.59 12 125205 38275 63325530
Malignant glioma 41.37 13.59 9 125208 8 63363797
Upper respiratory tract infection 41.35 13.59 61 125156 81986 63281819
Prescribed underdose 41.26 13.59 5 125212 29684 63334121
Pneumoperitoneum 41.17 13.59 29 125188 1414 63362391
Joint injury 41.05 13.59 5 125212 29567 63334238
Tracheal fistula 40.96 13.59 11 125206 39 63363766
Portal vein thrombosis 40.89 13.59 37 125180 2593 63361212
Varices oesophageal 40.73 13.59 40 125177 3108 63360697
Blood bilirubin increased 40.66 13.59 163 125054 36977 63326828
Agitation 40.39 13.59 35 125182 59722 63304083
Retinal scar 40.30 13.59 14 125203 136 63363669
Colorectal cancer metastatic 40.16 13.59 21 125196 592 63363213
Cystitis radiation 40.14 13.59 12 125205 68 63363737
Onycholysis 40.12 13.59 30 125187 1606 63362199
Macular scar 39.53 13.59 13 125204 105 63363700
Bradycardia 39.34 13.59 52 125165 73175 63290630
Intraocular pressure increased 39.27 13.59 54 125163 6024 63357781
Vitreous opacities 39.27 13.59 17 125200 310 63363495
Drug withdrawal syndrome 39.26 13.59 4 125213 27190 63336615
Enterovesical fistula 38.93 13.59 20 125197 543 63363262
Breast cancer metastatic 38.62 13.59 78 125139 11940 63351865
Dyskinesia 38.60 13.59 8 125209 31994 63331811
Haemolytic uraemic syndrome 38.49 13.59 35 125182 2468 63361337
Hallucination 38.41 13.59 31 125186 54786 63309019
Nail toxicity 38.20 13.59 17 125200 332 63363473
Nasal congestion 38.03 13.59 44 125173 65616 63298189
Metastases to spine 37.85 13.59 39 125178 3210 63360595
Eye irritation 37.71 13.59 112 125105 21859 63341946
Product prescribing error 37.61 13.59 4 125213 26285 63337520
Neutrophil count 37.51 13.59 16 125201 281 63363524
Sudden death 37.45 13.59 71 125146 10378 63353427
Pregnancy 37.30 13.59 13 125204 36823 63326982
Obesity 37.15 13.59 7 125210 29945 63333860
Cerebral haemorrhage 37.01 13.59 139 125078 30590 63333215
Gastrooesophageal reflux disease 36.72 13.59 84 125133 95555 63268250
Glioblastoma 36.63 13.59 22 125195 815 63362990
Fistula of small intestine 36.48 13.59 17 125200 371 63363434
Lower limb fracture 36.48 13.59 3 125214 24218 63339587
Macular fibrosis 36.40 13.59 17 125200 373 63363432
Mechanical ileus 36.26 13.59 19 125198 538 63363267
Neutrophil count abnormal 36.03 13.59 36 125181 2856 63360949
Serous cystadenocarcinoma ovary 35.70 13.59 9 125208 23 63363782
Retinal artery occlusion 35.48 13.59 28 125189 1625 63362180
Enterocolitis infectious 35.40 13.59 28 125189 1630 63362175
Abdominal infection 35.23 13.59 30 125187 1938 63361867
Gastrointestinal anastomotic leak 34.89 13.59 14 125203 209 63363596
Red cell distribution width increased 34.65 13.59 69 125148 10455 63353350
Proctalgia 34.64 13.59 51 125166 6059 63357746
Product use in unapproved indication 34.62 13.59 209 125008 178871 63184934
Pulpitis dental 34.54 13.59 22 125195 906 63362899
Rhabdomyolysis 34.53 13.59 22 125195 43929 63319876
Drug dependence 34.33 13.59 4 125213 24479 63339326
Febrile bone marrow aplasia 34.33 13.59 56 125161 7269 63356536
Inflammation 34.30 13.59 69 125148 82204 63281601
Urinary tract obstruction 34.20 13.59 31 125186 2177 63361628
Multiple sclerosis 34.13 13.59 4 125213 24368 63339437
Hypertensive encephalopathy 33.84 13.59 19 125198 619 63363186
Tremor 33.77 13.59 140 125077 132099 63231706
Anastomotic fistula 33.71 13.59 9 125208 31 63363774
Medication error 33.69 13.59 32 125185 52252 63311553
Delirium 33.68 13.59 30 125187 50511 63313294
Metabolic acidosis 33.48 13.59 24 125193 45045 63318760
Duodenal ulcer 33.28 13.59 57 125160 7699 63356106
Drug effective for unapproved indication 33.23 13.59 37 125180 3327 63360478
Choroidal neovascularisation 33.20 13.59 15 125202 304 63363501
Metastases to skin 33.20 13.59 27 125190 1636 63362169
Burning sensation 33.11 13.59 35 125182 54372 63309433
Pseudoendophthalmitis 33.09 13.59 8 125209 16 63363789
Alopecia 32.95 13.59 468 124749 337068 63026737
Peripheral motor neuropathy 32.94 13.59 27 125190 1654 63362151
Haemolytic anaemia 32.88 13.59 66 125151 10059 63353746
Venous pressure jugular decreased 32.86 13.59 9 125208 35 63363770
Bursitis 32.77 13.59 16 125201 37025 63326780
Extravasation 32.30 13.59 31 125186 2341 63361464
Aortoenteric fistula 32.29 13.59 7 125210 6 63363799
Swelling face 32.17 13.59 47 125170 63428 63300377
Intestinal metastasis 31.90 13.59 12 125205 149 63363656
Ophthalmological examination abnormal 31.90 13.59 10 125207 68 63363737
Cutis laxa 31.83 13.59 12 125205 150 63363655
Stoma site haemorrhage 31.67 13.59 22 125195 1049 63362756
Nephrolithiasis 31.66 13.59 22 125195 41962 63321843
Macular hole 31.56 13.59 20 125197 816 63362989
Gastrointestinal necrosis 31.54 13.59 33 125184 2765 63361040
Hypopyon 31.41 13.59 19 125198 713 63363092
Retinal neovascularisation 31.04 13.59 9 125208 45 63363760
Vaginal fistula 30.96 13.59 16 125201 440 63363365
Device issue 30.72 13.59 5 125212 23776 63340029
Rash pruritic 30.58 13.59 44 125173 59755 63304050
Performance status decreased 30.54 13.59 37 125180 3641 63360164
Periodontitis 30.36 13.59 35 125182 3268 63360537
Blood pressure fluctuation 30.26 13.59 28 125189 46289 63317516
Hyperammonaemia 30.13 13.59 44 125173 5188 63358617
Sciatica 30.10 13.59 15 125202 34309 63329496
Aphasia 30.07 13.59 137 125080 32863 63330942
Eczema 30.04 13.59 13 125204 32278 63331527
Accidental overdose 29.89 13.59 5 125212 23304 63340501
Device dislocation 29.85 13.59 7 125210 25698 63338107
Ovarian cancer 29.80 13.59 47 125170 5929 63357876
Biliary fistula 29.65 13.59 7 125210 12 63363793
Ureteric fistula 29.65 13.59 7 125210 12 63363793
Cerebral infarction 29.54 13.59 109 125108 23784 63340021
Choroiditis 29.49 13.59 12 125205 186 63363619
Incisional hernia 29.47 13.59 25 125192 1607 63362198
Bronchial fistula 29.23 13.59 8 125209 31 63363774
Toxic epidermal necrolysis 29.22 13.59 7 125210 25327 63338478
Colitis ischaemic 29.20 13.59 65 125152 10643 63353162
Vitreous disorder 29.17 13.59 10 125207 93 63363712
Thrombosis 29.05 13.59 223 124994 64532 63299273
Angiogram retina abnormal 28.96 13.59 6 125211 3 63363802
Vaginal perforation 28.95 13.59 7 125210 14 63363791
Oesophageal varices haemorrhage 28.87 13.59 22 125195 1212 63362593
Atypical haemolytic uraemic syndrome 28.79 13.59 18 125199 717 63363088
Magnetic resonance imaging head abnormal 28.73 13.59 27 125190 1986 63361819
Polychromasia 28.38 13.59 11 125206 149 63363656
Adenocarcinoma 28.37 13.59 32 125185 2918 63360887
Product contamination microbial 28.33 13.59 12 125205 207 63363598
Metastases to kidney 28.33 13.59 12 125205 207 63363598
Cholecystitis acute 28.22 13.59 55 125162 8205 63355600
Colonic fistula 28.18 13.59 13 125204 277 63363528
Basal cell carcinoma 28.13 13.59 10 125207 27981 63335824
Lip swelling 28.12 13.59 13 125204 31050 63332755
Grip strength decreased 28.09 13.59 5 125212 22282 63341523
Hypoglycaemia 28.04 13.59 47 125170 60018 63303787
Lymphadenopathy mediastinal 27.93 13.59 31 125186 2777 63361028
Road traffic accident 27.88 13.59 19 125198 36613 63327192
Haemorrhage 27.85 13.59 211 125006 60811 63302994
Pelvic infection 27.84 13.59 14 125203 363 63363442
Carpal tunnel syndrome 27.75 13.59 4 125213 20813 63342992
Metastases to pelvis 27.66 13.59 15 125202 456 63363349
Diabetes mellitus 27.63 13.59 42 125175 55768 63308037
Hypertransaminasaemia 27.61 13.59 48 125169 6561 63357244
Central nervous system haemorrhage 27.55 13.59 11 125206 162 63363643
Pharyngeal oedema 27.51 13.59 74 125143 13647 63350158
Necrosis 27.15 13.59 43 125174 5444 63358361
Iridocyclitis 27.11 13.59 29 125188 2493 63361312
Oligoastrocytoma 26.95 13.59 7 125210 21 63363784
Malaise 26.91 13.59 620 124597 415334 62948471
Immune-mediated hepatitis 26.83 13.59 22 125195 1349 63362456
Anterior chamber inflammation 26.69 13.59 13 125204 314 63363491
Gastropleural fistula 26.66 13.59 8 125209 46 63363759
Embolism venous 26.64 13.59 32 125185 3122 63360683
Gait inability 26.07 13.59 40 125177 52919 63310886
Anastomotic complication 26.03 13.59 10 125207 132 63363673
Thrombophlebitis migrans 26.03 13.59 10 125207 132 63363673
Colon cancer metastatic 25.79 13.59 20 125197 1131 63362674
Seasonal allergy 25.77 13.59 5 125212 20945 63342860
BRCA2 gene mutation 25.76 13.59 9 125208 89 63363716
Melanoderma 25.69 13.59 11 125206 195 63363610
Incorrect route of product administration 25.62 13.59 11 125206 27441 63336364
Neutropenic sepsis 25.60 13.59 81 125136 16357 63347448
Rectal haemorrhage 25.53 13.59 175 125042 48855 63314950
Hypotension 25.53 13.59 381 124836 272223 63091582
Autoimmune haemolytic anaemia 25.50 13.59 38 125179 4563 63359242
Hydrocephalus 25.49 13.59 41 125176 5259 63358546
Amnesia 25.48 13.59 44 125173 55541 63308264
Cervix carcinoma recurrent 25.44 13.59 10 125207 141 63363664
Retinal aneurysm 25.44 13.59 11 125206 200 63363605
Intracranial tumour haemorrhage 25.39 13.59 11 125206 201 63363604
Enterocolitis 25.25 13.59 51 125166 7807 63355998
Perirectal abscess 25.07 13.59 18 125199 905 63362900
Respiratory tract infection 24.89 13.59 27 125190 41456 63322349
Eosinophilia 24.88 13.59 7 125210 22749 63341056
Tooth erosion 24.85 13.59 14 125203 459 63363346
Pneumatosis intestinalis 24.63 13.59 27 125190 2386 63361419
Lacrimation increased 24.58 13.59 93 125124 20538 63343267
Heart rate increased 24.53 13.59 99 125118 94139 63269666
Infected lymphocele 24.53 13.59 11 125206 219 63363586
Psychotic disorder 24.48 13.59 10 125207 25702 63338103
Granulocyte count decreased 24.48 13.59 20 125197 1220 63362585
Throat irritation 24.31 13.59 23 125194 37624 63326181
Aggression 24.30 13.59 8 125209 23490 63340315
Paraneoplastic dermatomyositis 24.19 13.59 6 125211 14 63363791
Oesophageal fistula 24.18 13.59 10 125207 162 63363643
Jaundice 24.15 13.59 118 125099 29133 63334672
Hypocalcaemia 24.11 13.59 125 125092 31588 63332217
Crying 24.04 13.59 8 125209 23335 63340470
Bone pain 23.86 13.59 187 125030 54454 63309351
Confusional state 23.66 13.59 326 124891 236054 63127751
Mycotic endophthalmitis 23.57 13.59 8 125209 72 63363733
Colitis ulcerative 23.49 13.59 11 125206 26080 63337725
Joint effusion 23.40 13.59 3 125214 17057 63346748
Inferior vena cava stenosis 23.36 13.59 6 125211 17 63363788
Iritis 23.27 13.59 30 125187 3145 63360660
Anaemia of malignant disease 23.25 13.59 14 125203 521 63363284
Thrombotic thrombocytopenic purpura 23.17 13.59 33 125184 3803 63360002
Arterioenteric fistula 23.10 13.59 6 125211 18 63363787
Intestinal fistula 23.05 13.59 17 125200 891 63362914
Procedural pain 22.91 13.59 7 125210 21562 63342243
Post procedural fistula 22.88 13.59 11 125206 258 63363547
Rectal cancer recurrent 22.86 13.59 6 125211 19 63363786
Retinal ischaemia 22.77 13.59 12 125205 344 63363461
Urine protein/creatinine ratio increased 22.76 13.59 15 125202 655 63363150
Loss of consciousness 22.74 13.59 138 125079 117983 63245822
Necrotising fasciitis 22.70 13.59 29 125188 3012 63360793
Hepatic pain 22.59 13.59 29 125188 3027 63360778
Ankle fracture 22.52 13.59 4 125213 17851 63345954
Biliary dilatation 22.49 13.59 25 125192 2244 63361561
Arteriospasm coronary 22.32 13.59 33 125184 3935 63359870
Influenza like illness 22.31 13.59 63 125154 66761 63297044
Hyponatraemia 22.31 13.59 327 124890 111573 63252232
Neoplasm malignant 22.22 13.59 117 125100 29744 63334061
Tumour fistulisation 22.18 13.59 6 125211 22 63363783
Intestinal strangulation 22.14 13.59 8 125209 88 63363717
Retroperitoneal lymphadenopathy 22.10 13.59 14 125203 571 63363234
Seizure 22.06 13.59 376 124841 132258 63231547
Splenic artery thrombosis 22.03 13.59 7 125210 50 63363755
Dysaesthesia 22.03 13.59 35 125182 4443 63359362
Tumour invasion 21.92 13.59 9 125208 143 63363662
Blindness unilateral 21.86 13.59 42 125175 6199 63357606
Impaired work ability 21.85 13.59 4 125213 17471 63346334
Drug tolerance decreased 21.85 13.59 4 125213 17469 63346336
Acute coronary syndrome 21.72 13.59 56 125161 10070 63353735
Disease recurrence 21.67 13.59 111 125106 27919 63335886
Foot fracture 21.66 13.59 10 125207 23904 63339901
Cardiotoxicity 21.65 13.59 50 125167 8388 63355417
Swollen tongue 21.61 13.59 22 125195 34778 63329027
Product counterfeit 21.58 13.59 9 125208 149 63363656
Dysaesthesia pharynx 21.58 13.59 9 125208 149 63363656
Peritoneal neoplasm 21.57 13.59 7 125210 54 63363751
Hepatic lesion 21.42 13.59 36 125181 4789 63359016
Cardiac ventricular thrombosis 21.38 13.59 14 125203 605 63363200
Pelvic fluid collection 21.34 13.59 16 125201 860 63362945
Gastroenteritis viral 21.33 13.59 10 125207 23690 63340115
Disability 21.29 13.59 5 125212 18342 63345463
Myoclonus 21.26 13.59 3 125214 15865 63347940
Blood pressure decreased 21.20 13.59 62 125155 64960 63298845
Optic neuropathy 21.20 13.59 23 125194 2009 63361796
Mood swings 21.13 13.59 5 125212 18243 63345562
Bladder perforation 21.05 13.59 9 125208 159 63363646
Neoplasm recurrence 21.04 13.59 26 125191 2612 63361193
Systemic infection 20.99 13.59 35 125182 4625 63359180
Thyroiditis 20.79 13.59 25 125192 2441 63361364
Retinal vascular occlusion 20.72 13.59 12 125205 415 63363390
Diabetic retinal oedema 20.69 13.59 11 125206 321 63363484
Charles Bonnet syndrome 20.68 13.59 5 125212 10 63363795
Unevaluable event 20.65 13.59 44 125173 51342 63312463
Secondary cerebellar degeneration 20.62 13.59 7 125210 63 63363742
Optic ischaemic neuropathy 20.60 13.59 18 125199 1204 63362601
Lip dry 20.56 13.59 3 125214 15467 63348338
Exostosis 20.47 13.59 5 125212 17857 63345948
Second primary malignancy 20.27 13.59 47 125170 7906 63355899
Retinal cyst 20.24 13.59 7 125210 67 63363738
Gallbladder disorder 20.22 13.59 6 125211 18836 63344969
Gallbladder rupture 20.21 13.59 12 125205 435 63363370
Angioedema 20.18 13.59 40 125177 47925 63315880
Therapeutic response unexpected 20.09 13.59 6 125211 18753 63345052
Intestinal ischaemia 19.99 13.59 45 125172 7423 63356382
Hypervolaemia 19.99 13.59 16 125201 28397 63335408
Tumour pain 19.99 13.59 19 125198 1418 63362387
Nervousness 19.91 13.59 19 125198 30960 63332845
Recurrent cancer 19.88 13.59 22 125195 1965 63361840
Metastases to abdominal cavity 19.85 13.59 12 125205 450 63363355
Head injury 19.82 13.59 15 125202 27381 63336424
Hypermutation 19.78 13.59 6 125211 36 63363769
Respiratory disorder 19.74 13.59 29 125188 39053 63324752
Congestive cardiomyopathy 19.72 13.59 40 125177 6142 63357663
Tachyphylaxis 19.65 13.59 10 125207 266 63363539
Focal segmental glomerulosclerosis 19.64 13.59 19 125198 1449 63362356
Mediastinal disorder 19.55 13.59 11 125206 360 63363445
Eye pain 19.54 13.59 124 125093 33730 63330075
Perforation bile duct 19.51 13.59 5 125212 14 63363791
Right ventricular failure 19.33 13.59 5 125212 17183 63346622
Splenomegaly 19.26 13.59 57 125160 11100 63352705
Failure to anastomose 19.25 13.59 5 125212 15 63363790
Hyperhidrosis 19.21 13.59 129 125088 107707 63256098
Hepatic cirrhosis 19.16 13.59 98 125119 24636 63339169
Immune-mediated pancreatitis 19.15 13.59 8 125209 133 63363672
Cognitive disorder 19.10 13.59 52 125165 55763 63308042
Retinal depigmentation 19.09 13.59 10 125207 283 63363522
Kidney infection 19.05 13.59 11 125206 23165 63340640
Metastases to vagina 19.01 13.59 5 125212 16 63363789
Mental disorder 18.99 13.59 14 125203 25905 63337900
Fungal infection 18.98 13.59 27 125190 36847 63326958
Psoas abscess 18.91 13.59 12 125205 491 63363314
Dry mouth 18.91 13.59 84 125133 77779 63286026
Trichomegaly 18.90 13.59 7 125210 83 63363722
Haemoglobin decreased 18.88 13.59 397 124820 145088 63218717
Glomerulonephritis membranoproliferative 18.88 13.59 9 125208 207 63363598
Short-bowel syndrome 18.80 13.59 12 125205 496 63363309
Infusion site pain 18.80 13.59 5 125212 16864 63346941
Blood glucose increased 18.78 13.59 93 125124 83663 63280142
Transaminases 18.75 13.59 7 125210 85 63363720
Ureteric stenosis 18.75 13.59 13 125204 618 63363187
Intestinal prolapse 18.68 13.59 8 125209 142 63363663
Bleeding varicose vein 18.62 13.59 10 125207 298 63363507
Drug resistance 18.56 13.59 92 125125 22841 63340964
Lymphoedema 18.56 13.59 58 125159 11634 63352171
Infection 18.56 13.59 329 124888 228844 63134961
Retinal vein occlusion 18.52 13.59 22 125195 2121 63361684
Dry age-related macular degeneration 18.42 13.59 9 125208 219 63363586
Nail disorder 18.35 13.59 62 125155 12953 63350852
Vena cava thrombosis 18.16 13.59 22 125195 2165 63361640
Brachiocephalic vein thrombosis 18.12 13.59 7 125210 94 63363711
Liver injury 18.11 13.59 60 125157 60460 63303345
Glioblastoma multiforme 18.09 13.59 14 125203 789 63363016
Lupus-like syndrome 18.09 13.59 4 125213 15291 63348514
Tendonitis 18.08 13.59 8 125209 19607 63344198
Aneurysm 18.05 13.59 25 125192 2808 63360997
Anterior chamber cell 18.05 13.59 12 125205 532 63363273
Arterial thrombosis 18.05 13.59 18 125199 1425 63362380
Injection site haemorrhage 17.99 13.59 13 125204 24301 63339504
Toxic cardiomyopathy 17.99 13.59 8 125209 156 63363649
Wound decomposition 17.95 13.59 5 125212 21 63363784
Breast necrosis 17.94 13.59 8 125209 157 63363648
Abdominal hernia 17.89 13.59 34 125183 4978 63358827
Abnormal behaviour 17.85 13.59 10 125207 21416 63342389
Blood pressure increased 17.83 13.59 432 124785 161630 63202175
Pulmonary fibrosis 17.80 13.59 32 125185 39777 63324028
Surgery 17.80 13.59 27 125190 35885 63327920
Coma 17.79 13.59 66 125151 64298 63299507
Panic attack 17.79 13.59 11 125206 22320 63341485
Pancytopenia 17.67 13.59 279 124938 96654 63267151
Acquired gene mutation 17.63 13.59 15 125202 968 63362837
Renal tubular disorder 17.59 13.59 24 125193 2658 63361147
Immunodeficiency 17.54 13.59 9 125208 20245 63343560
Exposed bone in jaw 17.43 13.59 25 125192 2900 63360905
Pulmonary artery thrombosis 17.37 13.59 13 125204 697 63363108
Hyperpyrexia 17.34 13.59 28 125189 3604 63360201
Metastases to bone marrow 17.31 13.59 11 125206 451 63363354
Cystitis haemorrhagic 17.30 13.59 30 125187 4093 63359712
Radiation oesophagitis 17.29 13.59 10 125207 345 63363460
Exudative retinopathy 17.27 13.59 4 125213 6 63363799
Cardiac failure congestive 17.26 13.59 109 125108 92324 63271481
Soft tissue necrosis 17.22 13.59 12 125205 575 63363230
Breast cancer female 17.18 13.59 3 125214 13556 63350249
Catheter site injury 17.07 13.59 9 125208 258 63363547
Visual field defect 16.97 13.59 39 125178 6522 63357283
Bone density decreased 16.92 13.59 4 125213 14608 63349197
Metastases to soft tissue 16.90 13.59 8 125209 181 63363624
Malignant hypertension 16.80 13.59 16 125201 1197 63362608
Obstructive airways disorder 16.76 13.59 10 125207 20689 63343116
Thrombocytopenic purpura 16.75 13.59 17 125200 1374 63362431
Heart rate decreased 16.70 13.59 41 125176 45519 63318286
Localised infection 16.69 13.59 21 125196 30189 63333616
Toxic anterior segment syndrome 16.67 13.59 19 125198 1752 63362053
Birdshot chorioretinopathy 16.60 13.59 6 125211 66 63363739
Intercepted medication error 16.59 13.59 12 125205 610 63363195
Herpes zoster 16.58 13.59 95 125122 82367 63281438
Application site recall reaction 16.54 13.59 4 125213 8 63363797
Metastases to abdominal wall 16.51 13.59 7 125210 121 63363684
Trichiasis 16.29 13.59 6 125211 70 63363735
Jugular vein thrombosis 16.21 13.59 25 125192 3093 63360712
Skin hyperpigmentation 16.21 13.59 36 125181 5885 63357920
Hepatic vein stenosis 16.08 13.59 5 125212 33 63363772
Limb discomfort 16.06 13.59 21 125196 29695 63334110
White blood cell count increased 16.05 13.59 46 125171 48515 63315290
Gingival bleeding 16.05 13.59 58 125159 12529 63351276
Intracranial hypotension 15.98 13.59 9 125208 295 63363510
Wound necrosis 15.91 13.59 10 125207 402 63363403
Onychalgia 15.77 13.59 14 125203 957 63362848
Retinal telangiectasia 15.69 13.59 3 125214 0 63363805
Cytoreductive surgery 15.69 13.59 3 125214 0 63363805
Detachment of macular retinal pigment epithelium 15.69 13.59 3 125214 0 63363805
Thyroid gland abscess 15.69 13.59 3 125214 0 63363805
Instillation site complication 15.69 13.59 3 125214 0 63363805
Cyclitis 15.69 13.59 3 125214 0 63363805
Iron deficiency anaemia 15.68 13.59 10 125207 19959 63343846
Subclavian vein thrombosis 15.67 13.59 19 125198 1871 63361934
Depressed mood 15.66 13.59 35 125182 40156 63323649
Colorectal cancer recurrent 15.66 13.59 4 125213 11 63363794
Nail discolouration 15.65 13.59 23 125194 2727 63361078
Failure to thrive 15.64 13.59 40 125177 7158 63356647
Subretinal fibrosis 15.63 13.59 6 125211 79 63363726
Night sweats 15.58 13.59 47 125170 48767 63315038
Metastases to gastrointestinal tract 15.57 13.59 6 125211 80 63363725
Immune-mediated enterocolitis 15.55 13.59 20 125197 2091 63361714
Hiatus hernia 15.39 13.59 12 125205 21582 63342223
Orthostatic hypotension 15.35 13.59 30 125187 36130 63327675
Blood creatinine increased 15.32 13.59 251 124966 87593 63276212
Heart rate irregular 15.31 13.59 13 125204 22408 63341397
Pneumonia chlamydial 15.30 13.59 6 125211 84 63363721
Bacterial diarrhoea 15.24 13.59 6 125211 85 63363720
Glomerulonephropathy 15.24 13.59 6 125211 85 63363720
Hyperbilirubinaemia 15.17 13.59 53 125164 11261 63352544
Conjunctival hyperaemia 15.17 13.59 21 125196 2358 63361447
Tumour cavitation 15.16 13.59 4 125213 13 63363792
Rash papular 15.12 13.59 6 125211 15696 63348109
Cutaneous tuberculosis 15.10 13.59 7 125210 151 63363654
Balance disorder 15.03 13.59 101 125116 84321 63279484
Breast cancer recurrent 14.94 13.59 29 125188 4312 63359493
Restless legs syndrome 14.94 13.59 9 125208 18522 63345283
Infectious pleural effusion 14.93 13.59 17 125200 1566 63362239
Head discomfort 14.90 13.59 4 125213 13411 63350394
Chondronecrosis 14.83 13.59 5 125212 44 63363761
Limb injury 14.83 13.59 17 125200 25460 63338345
Thrombophlebitis 14.82 13.59 29 125188 4339 63359466
Respiratory arrest 14.81 13.59 26 125191 32619 63331186
Metastases to spleen 14.77 13.59 7 125210 159 63363646
White blood cell count 14.75 13.59 6 125211 93 63363712
Emotional distress 14.70 13.59 26 125191 32523 63331282
Skin discolouration 14.70 13.59 33 125184 37795 63326010
Uterine adhesions 14.63 13.59 5 125212 46 63363759
Rectal ulcer 14.60 13.59 15 125202 1230 63362575
Sputum discoloured 14.55 13.59 7 125210 16340 63347465
Creatinine renal clearance decreased 14.49 13.59 7 125210 16301 63347504
Blood glucose decreased 14.49 13.59 12 125205 20940 63342865
Ulcerative keratitis 14.47 13.59 22 125195 2688 63361117
Vesical fistula 14.46 13.59 6 125211 98 63363707
Macular detachment 14.46 13.59 6 125211 98 63363707
Catheter site thrombosis 14.45 13.59 7 125210 167 63363638
Gastrointestinal obstruction 14.42 13.59 14 125203 1073 63362732
Unresponsive to stimuli 14.40 13.59 28 125189 33788 63330017
Chest discomfort 14.35 13.59 143 125074 109826 63253979
Paraneoplastic syndrome 14.34 13.59 11 125206 612 63363193
Microangiopathic haemolytic anaemia 14.34 13.59 11 125206 612 63363193
Pulmonary arterial hypertension 14.33 13.59 14 125203 22563 63341242
Epilepsy 14.32 13.59 97 125120 26968 63336837
Rash macular 14.25 13.59 15 125202 23349 63340456
Dermatitis allergic 14.25 13.59 6 125211 15142 63348663
Pneumocephalus 14.23 13.59 7 125210 173 63363632
Peripheral paralysis 14.19 13.59 6 125211 103 63363702
Tumour hyperprogression 14.19 13.59 6 125211 103 63363702
Skin fissures 14.12 13.59 52 125165 11336 63352469
Tooth disorder 14.12 13.59 21 125196 28136 63335669
Posterior capsule opacification 14.03 13.59 6 125211 106 63363699
Retinopathy proliferative 13.92 13.59 5 125212 54 63363751
Respiratory tract congestion 13.91 13.59 9 125208 17823 63345982
Hypersplenism 13.83 13.59 8 125209 276 63363529
Mean cell volume increased 13.82 13.59 25 125192 3526 63360279
Nail pigmentation 13.80 13.59 7 125210 185 63363620
Frequent bowel movements 13.80 13.59 15 125202 23007 63340798
Dystonia 13.78 13.59 5 125212 13814 63349991
Pelvic pain 13.74 13.59 58 125159 13461 63350344
Tongue ulceration 13.74 13.59 25 125192 3541 63360264
Impaired quality of life 13.72 13.59 5 125212 13778 63350027
Fear 13.66 13.59 7 125210 15759 63348046
Vitreous degeneration 13.63 13.59 4 125213 21 63363784
Pseudocyst 13.63 13.59 7 125210 190 63363615

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 1997.45 13.74 1937 94641 106140 34754213
Death 1366.06 13.74 3223 93355 394826 34465527
Proteinuria 1136.02 13.74 683 95895 17959 34842394
Gastrointestinal perforation 755.63 13.74 313 96265 3550 34856803
Off label use 718.96 13.74 2658 93920 416866 34443487
Endophthalmitis 628.40 13.74 267 96311 3241 34857112
Palmar-plantar erythrodysaesthesia syndrome 455.57 13.74 375 96203 16420 34843933
Myelosuppression 368.55 13.74 353 96225 18912 34841441
Drug interaction 338.88 13.74 102 96476 225844 34634509
Hypertension 310.51 13.74 954 95624 135489 34724864
Diarrhoea 301.81 13.74 1972 94606 387940 34472413
Neuropathy peripheral 273.02 13.74 666 95912 82597 34777756
Large intestine perforation 264.94 13.74 206 96372 8297 34852056
Intestinal perforation 261.88 13.74 210 96368 8850 34851503
Peritonitis 257.98 13.74 270 96308 16095 34844258
Macular oedema 256.59 13.74 136 96442 2778 34857575
Suspected transmission of an infectious agent via product 255.43 13.74 94 96484 754 34859599
Completed suicide 246.62 13.74 5 96573 98163 34762190
Epistaxis 235.20 13.74 506 96072 57745 34802608
Toxicity to various agents 228.97 13.74 135 96443 200227 34660126
Interstitial lung disease 220.14 13.74 528 96050 64754 34795599
Drug ineffective 199.88 13.74 625 95953 456126 34404227
Bone marrow failure 198.72 13.74 318 96260 28935 34831418
Metastases to lung 193.95 13.74 179 96399 9141 34851212
Stomatitis 189.89 13.74 385 96193 42129 34818224
Tumour haemorrhage 189.28 13.74 112 96466 2850 34857503
Metastases to liver 183.17 13.74 207 96371 13456 34846897
Product dose omission issue 170.41 13.74 59 96519 119652 34740701
Neoplasm progression 168.93 13.74 261 96317 23039 34837314
Decreased appetite 168.74 13.74 905 95673 165487 34694866
Oesophageal varices haemorrhage 167.85 13.74 106 96472 3040 34857313
Ascites 165.98 13.74 385 96193 46186 34814167
Small intestinal perforation 165.23 13.74 92 96486 2079 34858274
Nephrotic syndrome 163.21 13.74 146 96432 7157 34853196
Anastomotic leak 161.19 13.74 62 96516 569 34859784
Overdose 160.18 13.74 29 96549 91030 34769323
Tumour perforation 159.35 13.74 52 96526 277 34860076
Varices oesophageal 157.80 13.74 109 96469 3646 34856707
Vitreous floaters 155.22 13.74 106 96472 3479 34856874
Condition aggravated 152.61 13.74 184 96394 192012 34668341
Mucosal inflammation 143.93 13.74 325 96253 38297 34822056
Pulmonary embolism 143.06 13.74 558 96020 89188 34771165
Neutrophil count decreased 141.70 13.74 384 96194 50720 34809633
Wound dehiscence 141.23 13.74 97 96481 3214 34857139
Portal hypertension 138.82 13.74 104 96474 3958 34856395
Protein urine 138.35 13.74 62 96516 862 34859491
Intestinal obstruction 137.38 13.74 235 96343 22587 34837766
Bacterial endophthalmitis 132.60 13.74 32 96546 36 34860317
Dehydration 131.02 13.74 706 95872 129263 34731090
Tumour necrosis 127.41 13.74 65 96513 1223 34859130
Necrotising fasciitis 122.11 13.74 93 96485 3629 34856724
Rectal perforation 122.03 13.74 47 96531 433 34859920
Visual acuity reduced 115.79 13.74 180 96398 15969 34844384
Neutropenia 112.59 13.74 780 95798 155998 34704355
Gastrointestinal toxicity 109.74 13.74 77 96501 2642 34857711
No adverse event 107.56 13.74 212 96366 22715 34837638
Hospitalisation 104.75 13.74 16 96562 56886 34803467
Malignant neoplasm progression 103.13 13.74 499 96079 87547 34772806
Drug effective for unapproved indication 101.11 13.74 72 96506 2530 34857823
Vomiting 99.90 13.74 1084 95494 246537 34613816
Suture rupture 99.83 13.74 38 96540 338 34860015
Retinal haemorrhage 98.69 13.74 94 96484 4995 34855358
Pneumothorax 97.48 13.74 183 96395 18909 34841444
Neurotoxicity 94.92 13.74 175 96403 17835 34842518
Vitreous haemorrhage 92.99 13.74 66 96512 2307 34858046
Skin toxicity 92.08 13.74 88 96490 4696 34855657
Intentional product misuse 90.75 13.74 10 96568 45601 34814752
Increased insulin requirement 89.75 13.74 26 96552 85 34860268
Dizziness 89.57 13.74 307 96271 218214 34642139
Suicidal ideation 88.10 13.74 6 96572 40382 34819971
Protein urine present 87.31 13.74 89 96489 5139 34855214
Ileal perforation 85.62 13.74 42 96536 724 34859629
Rheumatoid arthritis 85.44 13.74 5 96573 38233 34822120
Rhabdomyolysis 84.92 13.74 41 96537 68122 34792231
Detachment of retinal pigment epithelium 84.64 13.74 37 96541 483 34859870
Feeling abnormal 83.53 13.74 35 96543 63200 34797153
Anastomotic complication 83.20 13.74 34 96544 371 34859982
Fall 82.47 13.74 286 96292 202599 34657754
Impaired healing 82.07 13.74 150 96428 15184 34845169
Metastases to central nervous system 81.75 13.74 107 96471 8098 34852255
Electrocardiogram QT prolonged 81.42 13.74 9 96569 40943 34819410
Varicose vein ruptured 80.27 13.74 22 96556 55 34860298
Nausea 79.22 13.74 1348 95230 338560 34521793
Haemorrhage 79.02 13.74 316 96262 51054 34809299
Injection site pain 79.01 13.74 8 96570 38997 34821356
Disseminated intravascular coagulation 78.38 13.74 181 96397 21635 34838718
Joint swelling 77.75 13.74 34 96544 59856 34800497
Plasma cell myeloma 76.96 13.74 12 96566 42025 34818328
Asthma 76.25 13.74 13 96565 42643 34817710
Deep vein thrombosis 75.79 13.74 369 96209 64879 34795474
Incorrect dose administered 75.47 13.74 11 96567 40504 34819849
Large intestinal obstruction 75.16 13.74 49 96529 1486 34858867
Alopecia 74.60 13.74 190 96388 24165 34836188
Aggression 73.94 13.74 10 96568 38954 34821399
Carcinoembryonic antigen increased 73.89 13.74 37 96541 668 34859685
Intentional product use issue 72.89 13.74 343 96235 59473 34800880
Oesophagobronchial fistula 72.63 13.74 25 96553 161 34860192
Bradycardia 72.54 13.74 61 96517 75357 34784996
Fatigue 72.41 13.74 1430 95148 369223 34491130
Perforation 72.05 13.74 27 96551 229 34860124
COVID-19 71.84 13.74 65 96513 77485 34782868
Portal vein thrombosis 71.62 13.74 69 96509 3719 34856634
Arthralgia 70.22 13.74 238 96340 169803 34690550
Prostate cancer 68.88 13.74 13 96565 39636 34820717
Anxiety 68.87 13.74 105 96473 99323 34761030
Embolism 68.73 13.74 96 96482 7733 34852620
Metastases to peritoneum 67.02 13.74 49 96529 1795 34858558
Haematotoxicity 66.81 13.74 97 96481 8097 34852256
Ileus 66.13 13.74 143 96435 16356 34843997
Abdominal pain 65.70 13.74 716 95862 162902 34697451
Adrenal insufficiency 64.80 13.74 129 96449 13918 34846435
Stomal varices 64.06 13.74 19 96559 69 34860284
Eye inflammation 63.21 13.74 51 96527 2167 34858186
Stoma site haemorrhage 63.08 13.74 36 96542 854 34859499
Duodenal perforation 63.07 13.74 41 96537 1237 34859116
Musculoskeletal stiffness 63.01 13.74 25 96553 46655 34813698
Cardiac failure congestive 62.55 13.74 83 96495 83187 34777166
Arteriospasm coronary 60.94 13.74 60 96518 3322 34857031
Hypopyon 60.66 13.74 27 96551 369 34859984
Hepatic function abnormal 60.47 13.74 263 96315 44100 34816253
Tremor 60.34 13.74 84 96494 82503 34777850
Subretinal fluid 59.76 13.74 27 96551 383 34859970
Thrombocytopenia 59.19 13.74 676 95902 155571 34704782
Metastases to meninges 58.27 13.74 41 96537 1413 34858940
Hallucination 58.25 13.74 35 96543 51463 34808890
Glomerular vascular disorder 57.64 13.74 19 96559 105 34860248
Angioedema 57.46 13.74 16 96562 37358 34822995
Neoplasm 57.13 13.74 73 96505 5394 34854959
Retinal oedema 56.36 13.74 30 96548 618 34859735
Cystoid macular oedema 56.33 13.74 31 96547 684 34859669
Acute kidney injury 56.31 13.74 555 96023 304433 34555920
Wrong technique in product usage process 56.09 13.74 15 96563 35971 34824382
Colon cancer metastatic 55.90 13.74 42 96536 1605 34858748
Peripheral swelling 55.76 13.74 78 96500 76463 34783890
Macular fibrosis 55.56 13.74 25 96553 351 34860002
Retinal pigment epithelial tear 55.56 13.74 23 96555 260 34860093
Pruritus 55.07 13.74 204 96374 141777 34718576
Dermatitis acneiform 54.49 13.74 76 96502 6113 34854240
Suspected counterfeit product 54.19 13.74 23 96555 278 34860075
Blindness 53.46 13.74 124 96454 14862 34845491
Haemoptysis 52.75 13.74 214 96364 34792 34825561
Drug dependence 51.66 13.74 4 96574 24213 34836140
Small intestinal obstruction 50.84 13.74 121 96457 14745 34845608
Tumour rupture 50.53 13.74 21 96557 240 34860113
Vitritis 49.99 13.74 31 96547 860 34859493
Cataract nuclear 49.90 13.74 26 96552 512 34859841
Lactic acidosis 49.66 13.74 17 96561 34755 34825598
Metastases to bone 49.41 13.74 105 96473 11865 34848488
Peripheral sensory neuropathy 49.36 13.74 76 96502 6684 34853669
Enteritis 49.19 13.74 84 96494 8058 34852295
Hypoglycaemia 49.17 13.74 47 96531 54593 34805760
Hypothyroidism 49.08 13.74 148 96430 20754 34839599
Pneumatosis intestinalis 48.47 13.74 57 96521 3866 34856487
Wound infection 48.10 13.74 77 96501 7002 34853351
Product use in unapproved indication 48.10 13.74 165 96413 117334 34743019
Cholangitis 47.77 13.74 86 96492 8603 34851750
Failure to anastomose 47.44 13.74 19 96559 196 34860157
Hyperammonaemia 47.08 13.74 72 96506 6295 34854058
Influenza 46.74 13.74 41 96537 49625 34810728
Drug level increased 46.16 13.74 4 96574 22092 34838261
Performance status decreased 46.03 13.74 57 96521 4080 34856273
Drug hypersensitivity 45.88 13.74 96 96482 80433 34779920
Hypotension 45.76 13.74 392 96186 221257 34639096
Product prescribing error 45.66 13.74 5 96573 22922 34837431
Myalgia 45.66 13.74 103 96475 84007 34776346
Blood glucose increased 45.66 13.74 71 96507 66647 34793706
Agitation 45.40 13.74 55 96523 57344 34803009
Psychotic disorder 44.71 13.74 7 96571 24445 34835908
Contraindicated product administered 44.58 13.74 4 96574 21477 34838876
Polyneuropathy 44.36 13.74 115 96463 14781 34845572
Adverse drug reaction 44.30 13.74 13 96565 29329 34831024
Depression 44.18 13.74 130 96448 96968 34763385
Accidental overdose 43.90 13.74 3 96575 20137 34840216
Subileus 43.72 13.74 49 96529 3154 34857199
Weight increased 43.47 13.74 123 96455 92910 34767443
Drug withdrawal syndrome 43.10 13.74 3 96575 19831 34840522
Cerebral infarction 43.09 13.74 170 96408 27285 34833068
Psoriatic arthropathy 43.00 13.74 3 96575 19795 34840558
Pain in extremity 42.03 13.74 193 96385 126320 34734033
Metamorphopsia 41.85 13.74 23 96555 506 34859847
Eastern Cooperative Oncology Group performance status worsened 41.74 13.74 29 96549 979 34859374
Abnormal behaviour 41.67 13.74 9 96569 24960 34835393
Sleep apnoea syndrome 41.59 13.74 4 96574 20317 34840036
Coma 41.44 13.74 39 96539 45639 34814714
Thrombotic microangiopathy 41.30 13.74 91 96487 10539 34849814
Metastasis 41.22 13.74 54 96524 4090 34856263
Fistula of small intestine 41.04 13.74 22 96556 460 34859893
Dysphonia 41.00 13.74 150 96428 23233 34837120
Venous thrombosis 40.94 13.74 49 96529 3386 34856967
Sedation 40.79 13.74 5 96573 21001 34839352
Aortic dissection 40.65 13.74 44 96534 2724 34857629
Gastric perforation 40.45 13.74 42 96536 2478 34857875
Acral peeling skin syndrome 40.37 13.74 12 96566 44 34860309
Bronchitis 40.26 13.74 34 96544 41929 34818424
Hemiparesis 40.18 13.74 115 96463 15663 34844690
Constipation 40.05 13.74 565 96013 136417 34723936
Retinal detachment 39.91 13.74 61 96517 5330 34855023
Gastrointestinal anastomotic leak 39.87 13.74 21 96557 423 34859930
Enterocolitis 39.81 13.74 76 96502 7950 34852403
Muscle spasms 39.77 13.74 93 96485 74908 34785445
Treatment noncompliance 39.67 13.74 14 96564 28086 34832267
Malignant ascites 39.61 13.74 21 96557 429 34859924
Transmission of an infectious agent via product 39.36 13.74 16 96562 172 34860181
Urticaria 39.32 13.74 70 96508 62307 34798046
Fistula 39.27 13.74 69 96509 6771 34853582
Blindness transient 39.19 13.74 39 96539 2187 34858166
Cytomegalovirus infection 38.69 13.74 12 96566 26123 34834230
Fluid retention 38.64 13.74 13 96565 26874 34833479
Posterior reversible encephalopathy syndrome 38.44 13.74 85 96493 9869 34850484
Anastomotic fistula 38.13 13.74 13 96565 81 34860272
Diabetic retinopathy 37.99 13.74 35 96543 1782 34858571
Psoriasis 37.79 13.74 31 96547 38781 34821572
Hiccups 37.70 13.74 85 96493 9997 34850356
Basal cell carcinoma 37.40 13.74 5 96573 19653 34840700
Irritability 37.16 13.74 11 96567 24679 34835674
Colorectal cancer metastatic 37.16 13.74 24 96554 716 34859637
Pyrexia 37.12 13.74 1192 95386 331821 34528532
Macular hole 37.08 13.74 16 96562 202 34860151
Nasal septum perforation 37.03 13.74 14 96564 122 34860231
Sinusitis 36.80 13.74 36 96542 41366 34818987
Asthenia 36.54 13.74 911 95667 244340 34616013
Disturbance in attention 36.50 13.74 13 96565 25932 34834421
Ciliary hyperaemia 36.21 13.74 10 96568 26 34860327
Leukoencephalopathy 35.98 13.74 51 96527 4164 34856189
Glioblastoma 35.93 13.74 27 96551 1032 34859321
Retinal vascular disorder 35.89 13.74 15 96563 174 34860179
Platelet count decreased 35.88 13.74 496 96082 119221 34741132
Pseudoendophthalmitis 35.68 13.74 11 96567 47 34860306
Loss of personal independence in daily activities 35.53 13.74 24 96554 33155 34827198
Myocardial infarction 35.48 13.74 193 96385 120892 34739461
Hepatic encephalopathy 35.44 13.74 105 96473 14580 34845773
Chronic kidney disease 35.30 13.74 37 96541 41173 34819180
Palpitations 35.27 13.74 35 96543 39951 34820402
Eye haemorrhage 35.15 13.74 51 96527 4254 34856099
Visual impairment 34.97 13.74 193 96385 35609 34824744
Venous thrombosis limb 34.86 13.74 35 96543 1984 34858369
Insomnia 34.81 13.74 158 96420 103749 34756604
Tumour marker increased 34.64 13.74 22 96556 637 34859716
Coronary artery disease 34.40 13.74 50 96528 48255 34812098
Abdominal discomfort 34.35 13.74 71 96507 59764 34800589
Somnolence 34.29 13.74 174 96404 110942 34749411
Pelvic abscess 34.24 13.74 25 96553 914 34859439
Osteonecrosis of jaw 34.14 13.74 118 96460 17771 34842582
Hyperhidrosis 33.95 13.74 102 96476 75590 34784763
Tracheal fistula 33.82 13.74 13 96565 119 34860234
Respiratory depression 33.77 13.74 3 96575 16242 34844111
Cellulitis 33.76 13.74 59 96519 52892 34807461
Hepatic failure 33.63 13.74 186 96392 34345 34826008
Cardiac arrest 33.55 13.74 144 96434 96015 34764338
Wheezing 33.45 13.74 39 96539 41363 34818990
Ocular discomfort 33.24 13.74 35 96543 2099 34858254
Bleeding varicose vein 33.17 13.74 17 96561 323 34860030
Oesophagitis 33.13 13.74 96 96482 13165 34847188
Anaemia of malignant disease 33.13 13.74 19 96559 455 34859898
Pancytopenia 32.90 13.74 143 96435 95014 34765339
Injection site erythema 32.88 13.74 3 96575 15896 34844457
Peritoneal disorder 32.76 13.74 16 96562 273 34860080
Pneumonia 32.74 13.74 758 95820 361869 34498484
Bronchial fistula 32.57 13.74 14 96564 175 34860178
Macular ischaemia 32.48 13.74 11 96567 67 34860286
Liver carcinoma ruptured 32.43 13.74 14 96564 177 34860176
Restlessness 32.22 13.74 15 96563 25467 34834886
Toxic epidermal necrolysis 31.93 13.74 10 96568 21636 34838717
Immune thrombocytopenia 31.84 13.74 75 96503 9077 34851276
Diverticular perforation 31.48 13.74 43 96535 3391 34856962
Non-infectious endophthalmitis 31.40 13.74 13 96565 147 34860206
Cardiac disorder 31.35 13.74 44 96534 43082 34817271
Retinal disorder 31.14 13.74 24 96554 953 34859400
Diabetes mellitus 31.01 13.74 51 96527 46822 34813531
Vitreous detachment 30.93 13.74 23 96555 865 34859488
Eosinophilia 30.82 13.74 17 96561 26205 34834148
Mean cell haemoglobin increased 30.75 13.74 30 96548 1642 34858711
Primary adrenal insufficiency 30.68 13.74 10 96568 53 34860300
Full blood count abnormal 30.61 13.74 7 96571 18661 34841692
Proteus infection 30.61 13.74 25 96553 1081 34859272
Metastases to adrenals 30.40 13.74 24 96554 988 34859365
Cerebral ischaemia 30.29 13.74 59 96519 6263 34854090
Gastrointestinal necrosis 30.02 13.74 42 96536 3387 34856966
Therapeutic product effect decreased 29.97 13.74 31 96547 34712 34825641
International normalised ratio increased 29.93 13.74 53 96525 47274 34813079
Pulmonary artery thrombosis 29.76 13.74 21 96557 727 34859626
Urinary occult blood 29.43 13.74 7 96571 7 34860346
Choroidal neovascularisation 29.36 13.74 14 96564 226 34860127
Oesophageal haemorrhage 28.75 13.74 26 96552 1292 34859061
Dyskinesia 28.64 13.74 13 96565 22400 34837953
Malignant glioma 28.64 13.74 8 96570 22 34860331
Inappropriate schedule of product administration 28.62 13.74 83 96495 62213 34798140
Acute abdomen 28.57 13.74 31 96547 1924 34858429
Perirectal abscess 28.52 13.74 29 96549 1669 34858684
Colitis 28.30 13.74 190 96388 37560 34822793
Eczema 28.14 13.74 8 96570 18428 34841925
Chronic obstructive pulmonary disease 28.12 13.74 58 96520 48860 34811493
Arthropathy 28.10 13.74 20 96558 26887 34833466
Anal haemorrhage 27.85 13.74 35 96543 2543 34857810
Rectal cancer metastatic 27.83 13.74 13 96565 200 34860153
Abdominal abscess 27.80 13.74 45 96533 4130 34856223
Intracranial tumour haemorrhage 27.71 13.74 15 96563 320 34860033
Ocular hypertension 27.49 13.74 21 96557 823 34859530
Embolism arterial 27.43 13.74 19 96559 638 34859715
Ureteric compression 27.32 13.74 14 96564 266 34860087
Macular scar 27.20 13.74 8 96570 28 34860325
Obstructive airways disorder 27.08 13.74 5 96573 15489 34844864
General physical health deterioration 26.96 13.74 501 96077 127768 34732585
Hypoferritinaemia 26.95 13.74 7 96571 13 34860340
Proctalgia 26.93 13.74 53 96525 5670 34854683
Drug intolerance 26.91 13.74 80 96498 59490 34800863
Cutis laxa 26.56 13.74 10 96568 86 34860267
Mean cell volume increased 26.54 13.74 38 96540 3131 34857222
Rectal ulcer 26.33 13.74 22 96556 982 34859371
Cardiogenic shock 26.23 13.74 21 96557 26597 34833756
Type II hypersensitivity 26.17 13.74 8 96570 33 34860320
Bladder perforation 26.14 13.74 14 96564 292 34860061
Pulmonary haemorrhage 26.13 13.74 75 96503 10229 34850124
Magnetic resonance imaging head abnormal 26.12 13.74 25 96553 1336 34859017
Memory impairment 26.06 13.74 50 96528 43268 34817085
Hyperkalaemia 26.02 13.74 101 96477 69288 34791065
Enterovesical fistula 26.02 13.74 20 96558 791 34859562
Duodenal ulcer perforation 25.84 13.74 27 96551 1605 34858748
Therapeutic product effect incomplete 25.73 13.74 64 96514 50477 34809876
Subretinal fibrosis 25.69 13.74 10 96568 95 34860258
Thrombophlebitis migrans 25.66 13.74 12 96566 185 34860168
Hot flush 25.50 13.74 9 96569 18057 34842296
Tumour thrombosis 25.24 13.74 10 96568 100 34860253
Metastatic neoplasm 25.16 13.74 36 96542 2964 34857389
Metastases to lymph nodes 24.98 13.74 46 96532 4682 34855671
Gastric varices 24.97 13.74 17 96561 555 34859798
Ventricular tachycardia 24.93 13.74 22 96556 26557 34833796
Induration 24.82 13.74 21 96557 954 34859399
Therapy cessation 24.75 13.74 8 96570 16965 34843388
Osteoporosis 24.63 13.74 3 96575 12665 34847688
Lip swelling 24.50 13.74 7 96571 16073 34844280
Swelling face 24.35 13.74 17 96561 23088 34837265
Uveitis 24.34 13.74 60 96518 7475 34852878
Anal fistula 24.20 13.74 49 96529 5350 34855003
Wound complication 23.96 13.74 31 96547 2319 34858034
Pneumoperitoneum 23.78 13.74 27 96551 1763 34858590
Granulocyte count decreased 23.78 13.74 19 96559 796 34859557
Enterocutaneous fistula 23.73 13.74 21 96557 1014 34859339
Poisoning 23.52 13.74 3 96575 12223 34848130
Pelvic venous thrombosis 23.44 13.74 17 96561 615 34859738
Thrombotic thrombocytopenic purpura 23.37 13.74 37 96541 3333 34857020
Myoclonus 23.20 13.74 6 96572 14719 34845634
Tumour invasion 23.14 13.74 13 96565 299 34860054
Prostatic specific antigen increased 23.10 13.74 6 96572 14674 34845679
Radiation necrosis 23.05 13.74 10 96568 128 34860225
Loss of consciousness 22.99 13.74 134 96444 82533 34777820
Medication error 22.98 13.74 22 96556 25543 34834810
Retinal exudates 22.86 13.74 18 96560 738 34859615
Vascular pseudoaneurysm 22.74 13.74 29 96549 2138 34858215
Jejunal perforation 22.73 13.74 12 96566 243 34860110
Intestinal metastasis 22.68 13.74 12 96566 244 34860109
Hyperammonaemic encephalopathy 22.67 13.74 30 96548 2294 34858059
Cholecystitis 22.61 13.74 73 96505 10615 34849738
Cytokine release syndrome 22.61 13.74 18 96560 22859 34837494
Clostridium difficile infection 22.58 13.74 12 96566 18886 34841467
Mycotic endophthalmitis 22.54 13.74 9 96569 92 34860261
Productive cough 22.44 13.74 44 96534 37769 34822584
Osteonecrosis 22.40 13.74 91 96487 14799 34845554
Prothrombin level decreased 22.18 13.74 21 96557 1107 34859246
Tongue geographic 22.13 13.74 5 96573 3 34860350
Colitis ulcerative 22.04 13.74 9 96569 16511 34843842
Respiratory arrest 22.03 13.74 27 96551 28016 34832337
Gastrointestinal disorder 22.02 13.74 165 96413 33783 34826570
Gout 21.88 13.74 13 96565 19240 34841113
Multiple organ dysfunction syndrome 21.88 13.74 123 96455 76443 34783910
Injection site swelling 21.76 13.74 3 96575 11524 34848829
Change of bowel habit 21.63 13.74 20 96558 1023 34859330
Cholecystitis acute 21.57 13.74 52 96526 6387 34853966
IIIrd nerve paralysis 21.57 13.74 15 96563 507 34859846
Burning sensation 21.51 13.74 12 96566 18382 34841971
Proctitis 21.45 13.74 30 96548 2419 34857934
Hypervolaemia 21.44 13.74 14 96564 19695 34840658
Glycosylated haemoglobin increased 21.35 13.74 3 96575 11357 34848996
Blindness unilateral 21.29 13.74 42 96536 4500 34855853
Hypoalbuminaemia 21.26 13.74 78 96500 12096 34848257
Infectious pleural effusion 21.25 13.74 30 96548 2440 34857913
Bronchopulmonary aspergillosis 21.22 13.74 7 96571 14652 34845701
Cachexia 20.90 13.74 55 96523 7131 34853222
Intravascular haemolysis 20.70 13.74 14 96564 452 34859901
Erectile dysfunction 20.69 13.74 16 96562 20621 34839732
EGFR gene mutation 20.67 13.74 10 96568 167 34860186
Retinal aneurysm 20.48 13.74 9 96569 119 34860234
Rectourethral fistula 20.40 13.74 6 96572 21 34860332
Intracranial hypotension 20.39 13.74 11 96567 233 34860120
Hepatic rupture 20.35 13.74 7 96571 45 34860308
Hallucination, visual 20.24 13.74 12 96566 17779 34842574
Hypercreatinaemia 20.20 13.74 10 96568 176 34860177
Blister 20.17 13.74 20 96558 22838 34837515
Unevaluable event 20.15 13.74 37 96541 32553 34827800
Stomal hernia 20.14 13.74 11 96567 239 34860114
Product administration error 20.09 13.74 10 96568 16334 34844019
Hyperbilirubinaemia 20.07 13.74 96 96482 16747 34843606
COVID-19 pneumonia 19.94 13.74 11 96567 16956 34843397
Post procedural fistula 19.93 13.74 8 96570 83 34860270
Microangiopathic haemolytic anaemia 19.91 13.74 18 96560 894 34859459
Device related thrombosis 19.90 13.74 20 96558 1135 34859218
Gastric varices haemorrhage 19.81 13.74 11 96567 247 34860106
Skin lesion 19.62 13.74 19 96559 21942 34838411
Migraine 19.59 13.74 12 96566 17466 34842887
Lymphangiosis carcinomatosa 19.58 13.74 18 96560 914 34859439
Ciliary body disorder 19.58 13.74 4 96574 0 34860353
Injury 19.55 13.74 17 96561 20670 34839683
Road traffic accident 19.53 13.74 12 96566 17438 34842915
Liver function test abnormal 19.46 13.74 35 96543 31039 34829314
Retinal artery occlusion 19.43 13.74 25 96553 1860 34858493
Type 2 diabetes mellitus 19.42 13.74 10 96568 16022 34844331
Muscle rigidity 19.25 13.74 3 96575 10515 34849838
Abscess 19.21 13.74 74 96504 11743 34848610
Bile duct stenosis 19.11 13.74 20 96558 1191 34859162
Rash pruritic 19.07 13.74 28 96550 26913 34833440
Subdural haematoma 19.03 13.74 17 96561 20404 34839949
Blood creatine phosphokinase increased 19.01 13.74 62 96516 44795 34815558
Colonic fistula 18.97 13.74 13 96565 429 34859924
Clostridium difficile colitis 18.77 13.74 10 96568 15720 34844633
Haematemesis 18.72 13.74 136 96442 27575 34832778
Hypertensive crisis 18.72 13.74 60 96518 8691 34851662
Tracheal injury 18.69 13.74 5 96573 11 34860342
Embolism venous 18.68 13.74 22 96556 1494 34858859
Hypophagia 18.66 13.74 122 96456 23900 34836453
Illness 18.66 13.74 7 96571 13522 34846831
Carbohydrate antigen 19-9 increased 18.61 13.74 10 96568 210 34860143
Intraocular pressure increased 18.60 13.74 44 96534 5339 34855014
Pulmonary oedema 18.58 13.74 68 96510 47461 34812892
Anterior chamber inflammation 18.55 13.74 11 96567 281 34860072
Localised infection 18.46 13.74 13 96565 17574 34842779
Anal ulcer 18.40 13.74 17 96561 869 34859484
Head injury 18.31 13.74 14 96564 18146 34842207
Nervousness 18.28 13.74 6 96572 12600 34847753
Stress 18.28 13.74 35 96543 30312 34830041
Unresponsive to stimuli 18.23 13.74 30 96548 27539 34832814
Hepatic lesion 18.22 13.74 35 96543 3677 34856676
Medulloblastoma 18.13 13.74 7 96571 65 34860288
Mouth ulceration 18.08 13.74 73 96505 11837 34848516
Lymphoma 18.05 13.74 6 96572 12501 34847852
Aphonia 18.05 13.74 33 96545 3340 34857013
Retinal vein occlusion 18.03 13.74 23 96555 1696 34858657
Blood glucose decreased 18.00 13.74 7 96571 13230 34847123
Swollen tongue 17.85 13.74 9 96569 14596 34845757
Eye pain 17.72 13.74 79 96499 13383 34846970
Haemobilia 17.62 13.74 12 96566 392 34859961
Underdose 17.60 13.74 8 96570 13772 34846581
Duodenal varices 17.58 13.74 5 96573 15 34860338
Tumour pseudoprogression 17.53 13.74 13 96565 487 34859866
Metastases to gastrointestinal tract 17.49 13.74 7 96571 72 34860281
Bronchiectasis 17.48 13.74 3 96575 9798 34850555
Cytokine storm 17.48 13.74 15 96563 695 34859658
Leukopenia 17.44 13.74 257 96321 62599 34797754
Adrenocorticotropic hormone deficiency 17.43 13.74 17 96561 930 34859423
Perihepatic abscess 17.43 13.74 8 96570 118 34860235
Hepatic atrophy 17.42 13.74 9 96569 174 34860179
Nephrolithiasis 17.40 13.74 36 96542 30297 34830056
Peritoneal neoplasm 17.38 13.74 6 96572 39 34860314
Arthritis 17.31 13.74 38 96540 31308 34829045
Emotional distress 17.28 13.74 10 96568 15016 34845337
Aplastic anaemia 17.27 13.74 3 96575 9713 34850640
Adverse event 17.25 13.74 16 96562 18861 34841492
Poor peripheral circulation 17.15 13.74 21 96557 1486 34858867
Blood pressure fluctuation 17.14 13.74 27 96551 25222 34835131
Haemoglobin 17.13 13.74 6 96572 41 34860312
Therapy partial responder 17.12 13.74 62 96516 9554 34850799
Lacrimation increased 17.11 13.74 57 96521 8425 34851928
Chest discomfort 17.03 13.74 85 96493 54445 34805908
Anal fissure 16.98 13.74 37 96541 4253 34856100
Red cell distribution width increased 16.94 13.74 46 96532 6077 34854276
Full blood count decreased 16.93 13.74 15 96563 18073 34842280
Urinary retention 16.92 13.74 48 96530 36240 34824113
Diabetic retinal oedema 16.88 13.74 9 96569 186 34860167
Dialysis 16.85 13.74 5 96573 11203 34849150
Alpha 1 foetoprotein decreased 16.82 13.74 4 96574 4 34860349
Pulmonary infarction 16.64 13.74 20 96558 1388 34858965
Paronychia 16.59 13.74 32 96546 3373 34856980
Ill-defined disorder 16.37 13.74 79 96499 13830 34846523
Retinal vascular occlusion 16.34 13.74 9 96569 199 34860154
Blood pressure decreased 16.26 13.74 80 96498 51435 34808918
Haptoglobin decreased 16.18 13.74 13 96565 549 34859804
Product substitution issue 16.13 13.74 4 96574 10091 34850262
Osteoarthritis 16.08 13.74 20 96558 20622 34839731
Impetigo 16.06 13.74 17 96561 1026 34859327
Exostosis of jaw 15.97 13.74 7 96571 92 34860261
Blood bilirubin increased 15.97 13.74 169 96409 38127 34822226
Ocular vascular disorder 15.95 13.74 8 96570 145 34860208
Angiogram retina abnormal 15.93 13.74 4 96574 6 34860347
Red blood cell sedimentation rate increased 15.92 13.74 3 96575 9159 34851194
Incisional hernia 15.89 13.74 19 96559 1311 34859042
Haematoma 15.89 13.74 29 96549 25576 34834777
Liver abscess 15.88 13.74 34 96544 3861 34856492
Mean platelet volume decreased 15.87 13.74 12 96566 463 34859890
Diabetic foot 15.84 13.74 28 96550 2760 34857593
Cranial nerve disorder 15.82 13.74 13 96565 567 34859786
Hypertensive encephalopathy 15.79 13.74 11 96567 373 34859980
Hypopituitarism 15.75 13.74 25 96553 2257 34858096
Pulmonary fistula 15.70 13.74 6 96572 54 34860299
Nasopharyngitis 15.65 13.74 121 96457 69847 34790506
Eczema impetiginous 15.58 13.74 5 96573 25 34860328
Rash macular 15.57 13.74 8 96570 12834 34847519
Rectal obstruction 15.55 13.74 4 96574 7 34860346
Pelvic sepsis 15.55 13.74 4 96574 7 34860346
Sudden death 15.55 13.74 83 96495 15118 34845235
Oesophageal ulcer 15.53 13.74 31 96547 3350 34857003
Rectal adenocarcinoma 15.50 13.74 15 96563 813 34859540
Microangiopathy 15.49 13.74 16 96562 938 34859415
Tractional retinal detachment 15.42 13.74 5 96573 26 34860327
Respiratory distress 15.32 13.74 49 96529 35616 34824737
Hepatic enzyme increased 15.22 13.74 56 96522 39024 34821329
End stage renal disease 15.19 13.74 3 96575 8858 34851495
Fear 15.17 13.74 5 96573 10471 34849882
IIIrd nerve paresis 15.14 13.74 7 96571 105 34860248
Aneurysm ruptured 15.09 13.74 12 96566 499 34859854
Blood potassium increased 15.05 13.74 14 96564 16481 34843872
Anger 15.02 13.74 7 96571 11877 34848476
Glioblastoma multiforme 15.01 13.74 14 96564 724 34859629
Right ventricular failure 15.00 13.74 3 96575 8781 34851572
Herpes zoster 14.96 13.74 47 96531 34352 34826001
Skin striae 14.94 13.74 13 96565 614 34859739
Lower gastrointestinal perforation 14.89 13.74 4 96574 9 34860344
Metabolic acidosis 14.86 13.74 66 96512 43614 34816739
Gastroenteritis radiation 14.86 13.74 10 96568 320 34860033
Pneumonitis 14.83 13.74 151 96427 33727 34826626
Visual field defect 14.80 13.74 36 96542 4447 34855906
Peripheral sensorimotor neuropathy 14.79 13.74 20 96558 1562 34858791
Blood creatinine decreased 14.77 13.74 28 96550 2913 34857440
Arterioenteric fistula 14.68 13.74 3 96575 0 34860353
Cyclitis 14.68 13.74 3 96575 0 34860353
Pachymeningitis 14.68 13.74 7 96571 113 34860240
Oral pain 14.60 13.74 64 96514 10763 34849590
Genital herpes zoster 14.59 13.74 4 96574 10 34860343
Ileus paralytic 14.58 13.74 43 96535 5954 34854399
Stevens-Johnson syndrome 14.58 13.74 18 96560 18621 34841732
Oxygen saturation decreased 14.55 13.74 88 96490 53730 34806623
Retinal tear 14.54 13.74 15 96563 878 34859475
Dyspnoea 14.49 13.74 873 95705 375909 34484444
Oesophageal irritation 14.48 13.74 6 96572 68 34860285
Chronic hepatitis B 14.42 13.74 5 96573 33 34860320
Joint stiffness 14.38 13.74 6 96572 10867 34849486
Glomerulonephritis membranoproliferative 14.31 13.74 11 96567 435 34859918
Atrophy of globe 14.30 13.74 5 96573 34 34860319
Oesophageal carcinoma 14.27 13.74 4 96574 9300 34851053
Ulcer 14.10 13.74 55 96523 8780 34851573
Intestinal ulcer perforation 14.07 13.74 4 96574 12 34860341
Ophthalmological examination abnormal 14.05 13.74 5 96573 36 34860317
Frequent bowel movements 14.02 13.74 9 96569 12778 34847575
Anaemia 13.98 13.74 783 95795 232552 34627801
Stoma site pain 13.96 13.74 13 96565 671 34859682
Blood cholesterol increased 13.91 13.74 22 96556 20521 34839832
Glioma 13.85 13.74 10 96568 359 34859994
Upper respiratory tract infection 13.79 13.74 46 96532 33013 34827340

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease progression 3442.23 12.68 2963 166571 181399 79393455
Proteinuria 2344.23 12.68 1216 168318 31286 79543568
Gastrointestinal perforation 1188.90 12.68 459 169075 5678 79569176
Hypertension 1179.71 12.68 2337 167197 328655 79246199
Endophthalmitis 1168.25 12.68 459 169075 5969 79568885
Myelosuppression 1036.61 12.68 783 168751 39513 79535341
Palmar-plantar erythrodysaesthesia syndrome 965.24 12.68 694 168840 32440 79542414
Neuropathy peripheral 937.40 12.68 1320 168214 139985 79434869
Death 893.52 12.68 2936 166598 563578 79011276
Neutrophil count decreased 841.56 12.68 1018 168516 92941 79481913
Off label use 623.62 12.68 3662 165872 903553 78671301
Bone marrow failure 613.31 12.68 645 168889 50462 79524392
Neutropenia 598.25 12.68 1646 167888 286064 79288790
Epistaxis 597.53 12.68 943 168591 110572 79464282
Intestinal perforation 591.53 12.68 401 169133 17025 79557829
Neoplasm progression 558.29 12.68 617 168917 51065 79523789
Malignant neoplasm progression 557.92 12.68 1021 168513 134969 79439885
Large intestine perforation 510.68 12.68 342 169192 14225 79560629
Metastases to liver 495.87 12.68 440 169094 27874 79546980
Ascites 490.36 12.68 699 168835 74863 79499991
Completed suicide 486.09 12.68 7 169527 245760 79329094
Diarrhoea 455.93 12.68 3312 166222 877177 78697677
Drug interaction 450.97 12.68 160 169374 415023 79159831
Metastases to lung 442.86 12.68 342 169192 17821 79557033
Joint swelling 434.24 12.68 52 169482 288594 79286260
Mucosal inflammation 429.64 12.68 657 168877 74923 79499931
Peritonitis 417.64 12.68 398 169136 27638 79547216
Anaemia 389.21 12.68 1922 167612 443093 79131761
Suspected transmission of an infectious agent via product 389.07 12.68 131 169403 1055 79573799
Macular oedema 386.26 12.68 202 169332 5272 79569582
Rheumatoid arthritis 381.38 12.68 14 169520 208456 79366398
Platelet count decreased 359.62 12.68 1068 168466 193596 79381258
Neurotoxicity 359.39 12.68 393 169141 32125 79542729
Thrombocytopenia 346.26 12.68 1294 168240 263965 79310889
Pulmonary embolism 319.12 12.68 944 168590 170710 79404144
Peripheral sensory neuropathy 305.98 12.68 240 169294 12793 79562061
Arthropathy 301.17 12.68 19 169515 177092 79397762
Intestinal obstruction 299.88 12.68 412 169122 42608 79532246
Synovitis 299.22 12.68 4 169530 150730 79424124
Drug ineffective 298.84 12.68 1236 168298 1079677 78495177
Posterior reversible encephalopathy syndrome 296.31 12.68 321 169213 25960 79548894
Contraindicated product administered 293.68 12.68 9 169525 157529 79417325
Small intestinal perforation 292.28 12.68 142 169392 3155 79571699
Condition aggravated 283.79 12.68 391 169143 500733 79074121
Wound dehiscence 283.37 12.68 176 169358 6419 79568435
Interstitial lung disease 278.31 12.68 688 168846 111912 79462942
Arthralgia 272.06 12.68 501 169033 571302 79003552
Peripheral swelling 270.89 12.68 117 169417 269500 79305354
Decreased appetite 270.38 12.68 1438 168096 340980 79233874
Febrile neutropenia 266.42 12.68 1084 168450 229915 79344939
Tumour necrosis 259.64 12.68 111 169423 1811 79573043
Visual acuity reduced 258.18 12.68 316 169218 29153 79545701
Bacterial endophthalmitis 253.83 12.68 62 169472 118 79574736
White blood cell count decreased 250.88 12.68 925 168609 187363 79387491
Product dose omission issue 247.74 12.68 108 169426 247429 79327425
Maternal exposure during pregnancy 243.50 12.68 11 169523 136527 79438327
Detachment of retinal pigment epithelium 239.79 12.68 83 169451 733 79574121
Therapeutic product effect decreased 235.55 12.68 34 169500 163829 79411025
Nephrotic syndrome 235.15 12.68 193 169341 10981 79563873
Tumour haemorrhage 234.17 12.68 132 169402 4012 79570842
Systemic lupus erythematosus 233.04 12.68 5 169529 121144 79453710
Protein urine 231.50 12.68 96 169438 1446 79573408
Overdose 227.03 12.68 56 169478 184150 79390704
Musculoskeletal stiffness 226.07 12.68 48 169486 174960 79399894
Retinal pigment epithelial tear 223.36 12.68 69 169465 407 79574447
Metastases to central nervous system 220.52 12.68 220 169314 16155 79558699
Embolism 218.74 12.68 204 169330 13778 79561076
Portal hypertension 214.05 12.68 152 169382 6956 79567898
Pain 212.96 12.68 775 168759 703027 78871827
Toxicity to various agents 212.38 12.68 356 169178 421184 79153670
Dehydration 209.35 12.68 1062 168472 247125 79327729
Anastomotic leak 203.91 12.68 79 169455 986 79573868
Vitreous floaters 202.13 12.68 148 169386 7108 79567746
Drug hypersensitivity 201.38 12.68 203 169331 298713 79276141
Metastases to bone 201.26 12.68 254 169280 24173 79550681
Polyneuropathy 200.36 12.68 252 169282 23899 79550955
Drug intolerance 198.61 12.68 162 169372 263957 79310897
Injection site pain 198.57 12.68 22 169512 129816 79445038
Tumour perforation 197.43 12.68 61 169473 360 79574494
Oesophageal varices haemorrhage 197.21 12.68 119 169415 4117 79570737
Osteonecrosis of jaw 196.89 12.68 340 169194 42886 79531968
Sinusitis 196.05 12.68 85 169449 195416 79379438
Varices oesophageal 194.13 12.68 134 169400 5857 79568997
Age-related macular degeneration 192.72 12.68 74 169460 900 79573954
Ileus 191.71 12.68 257 169277 25954 79548900
Small intestinal obstruction 189.76 12.68 261 169273 27011 79547843
Swelling 189.27 12.68 113 169421 216598 79358256
Metastases to meninges 188.18 12.68 109 169425 3492 79571362
Pneumothorax 188.02 12.68 265 169269 28058 79546796
Exposure during pregnancy 184.16 12.68 7 169527 101125 79473729
Metastases to peritoneum 183.61 12.68 115 169419 4257 79570597
Asthma 183.00 12.68 33 169501 135062 79439792
Glomerular vascular disorder 180.26 12.68 48 169486 148 79574706
Retinal haemorrhage 177.27 12.68 144 169390 8073 79566781
Abdominal pain 175.92 12.68 1422 168112 388147 79186707
Hepatic function abnormal 170.42 12.68 437 169097 72670 79502184
Vomiting 170.01 12.68 2160 167374 663668 78911186
Abdominal discomfort 169.15 12.68 170 169364 250557 79324297
Thrombotic microangiopathy 168.19 12.68 211 169323 19958 79554896
Rectal perforation 165.73 12.68 65 169469 840 79574014
Gastrointestinal toxicity 164.25 12.68 137 169397 7972 79566882
Nausea 159.83 12.68 2887 166647 954309 78620545
Dizziness 158.80 12.68 580 168954 525861 79048993
Stomatitis 155.98 12.68 672 168862 146085 79428769
Leukopenia 154.73 12.68 572 168962 115941 79458913
Fall 154.58 12.68 526 169008 487103 79087751
Weight increased 154.19 12.68 219 169315 277167 79297687
Intentional product misuse 153.74 12.68 13 169521 95152 79479702
Hepatic enzyme increased 151.47 12.68 101 169433 182509 79392345
Psoriatic arthropathy 150.87 12.68 3 169531 77996 79496858
Pruritus 144.02 12.68 399 169135 394249 79180605
Protein urine present 143.86 12.68 140 169394 9972 79564882
Feeling abnormal 143.26 12.68 80 169454 159119 79415735
Hepatic failure 142.77 12.68 366 169168 60846 79514008
Deep vein thrombosis 142.04 12.68 571 168963 120348 79454506
Skin toxicity 141.16 12.68 127 169407 8187 79566667
Haematotoxicity 140.13 12.68 169 169365 15350 79559504
Vitreous haemorrhage 139.39 12.68 91 169443 3622 79571232
Glossodynia 138.32 12.68 26 169508 103311 79471543
Suicide attempt 137.70 12.68 10 169524 82922 79491932
Drug effective for unapproved indication 137.61 12.68 109 169425 5892 79568962
Injection site erythema 134.05 12.68 8 169526 78189 79496665
Subileus 132.46 12.68 104 169430 5550 79569304
Hospitalisation 129.84 12.68 22 169512 94214 79480640
Dermatitis acneiform 128.58 12.68 131 169403 9862 79564992
Necrotising fasciitis 126.26 12.68 104 169430 5946 79568908
Hepatic atrophy 122.45 12.68 43 169491 398 79574456
Duodenal perforation 119.52 12.68 68 169466 2104 79572750
Suicidal ideation 119.11 12.68 12 169522 76328 79498526
Pericarditis 118.47 12.68 37 169497 104199 79470655
No adverse event 118.09 12.68 251 169283 36941 79537913
Blister 118.07 12.68 53 169481 119423 79455431
Urticaria 117.68 12.68 132 169402 185069 79389785
Pain in extremity 117.62 12.68 390 169144 364148 79210706
Loss of personal independence in daily activities 117.33 12.68 36 169498 102544 79472310
Cystoid macular oedema 117.13 12.68 65 169469 1915 79572939
Helicobacter infection 116.89 12.68 8 169526 69696 79505158
Nasal septum perforation 115.99 12.68 48 169486 719 79574135
Electrocardiogram QT prolonged 114.23 12.68 26 169508 90360 79484494
Eye inflammation 112.92 12.68 100 169434 6313 79568541
Photopsia 111.93 12.68 92 169442 5244 79569610
Constipation 111.15 12.68 1002 168532 282048 79292806
Depression 110.95 12.68 181 169353 216609 79358245
Insomnia 110.87 12.68 221 169313 244949 79329905
Dysphonia 109.57 12.68 317 169217 56555 79518299
Disseminated intravascular coagulation 109.34 12.68 238 169296 35604 79539250
Fibromyalgia 109.03 12.68 7 169527 64333 79510521
Portal vein thrombosis 108.91 12.68 94 169440 5733 79569121
Female genital tract fistula 108.87 12.68 95 169439 5880 79568974
Drug reaction with eosinophilia and systemic symptoms 108.83 12.68 7 169527 64237 79510617
Wheezing 108.80 12.68 56 169478 116608 79458246
Pleural effusion 108.24 12.68 601 168933 144661 79430193
General physical health deterioration 107.90 12.68 974 168560 274264 79300590
Carcinoembryonic antigen increased 107.88 12.68 64 169470 2145 79572709
Arthritis 107.34 12.68 55 169479 114825 79460029
Gastric perforation 107.18 12.68 80 169454 3957 79570897
Therapy partial responder 107.01 12.68 157 169377 17240 79557614
Psoriasis 106.95 12.68 29 169505 89558 79485296
Hydronephrosis 106.61 12.68 157 169377 17297 79557557
Wound 106.52 12.68 57 169477 116122 79458732
Anxiety 105.66 12.68 232 169302 248280 79326574
Irritable bowel syndrome 104.79 12.68 7 169527 62234 79512620
Hypertensive crisis 104.73 12.68 171 169363 20599 79554255
Treatment failure 103.48 12.68 126 169408 170360 79404494
Injury 102.64 12.68 20 169514 77476 79497378
Subretinal fluid 102.41 12.68 45 169489 787 79574067
Blood cholesterol increased 102.04 12.68 26 169508 83694 79491160
Eastern Cooperative Oncology Group performance status worsened 101.30 12.68 60 169474 2005 79572849
COVID-19 100.58 12.68 112 169422 157562 79417292
Mobility decreased 99.38 12.68 69 169465 122106 79452748
Suture rupture 98.91 12.68 40 169494 563 79574291
Nasopharyngitis 98.36 12.68 249 169285 253632 79321222
Discomfort 96.92 12.68 75 169459 125542 79449312
Aortic dissection 96.09 12.68 76 169458 4099 79570755
Cholangitis 94.54 12.68 126 169408 12650 79562204
Large intestinal obstruction 93.50 12.68 68 169466 3231 79571623
Suspected counterfeit product 93.13 12.68 38 169496 548 79574306
Lower respiratory tract infection 92.48 12.68 83 169451 129137 79445717
Rhabdomyolysis 91.08 12.68 53 169481 103078 79471776
Varicose vein ruptured 90.34 12.68 26 169508 115 79574739
Venous thrombosis limb 89.65 12.68 75 169459 4382 79570472
Stoma site haemorrhage 89.65 12.68 54 169480 1862 79572992
Influenza 89.51 12.68 86 169448 129520 79445334
Incorrect dose administered 89.26 12.68 26 169508 76604 79498250
Bradycardia 88.99 12.68 94 169440 135463 79439391
Bronchitis 88.71 12.68 88 169446 130556 79444298
Vitritis 87.67 12.68 52 169482 1742 79573112
Ileal perforation 87.42 12.68 43 169491 982 79573872
Injection site swelling 86.70 12.68 3 169531 47129 79527725
Metastases to lymph nodes 85.46 12.68 108 169426 10289 79564565
Neoplasm 85.14 12.68 101 169433 9015 79565839
Adrenal insufficiency 84.44 12.68 187 169347 28300 79546554
Red blood cell sedimentation rate increased 84.25 12.68 3 169531 45939 79528915
Product use issue 84.22 12.68 202 169332 209620 79365234
Venous thrombosis 83.86 12.68 89 169445 7027 79567827
Increased insulin requirement 83.09 12.68 26 169508 161 79574693
Retinal detachment 82.34 12.68 100 169434 9147 79565707
Sedation 81.37 12.68 8 169526 51887 79522967
Eye haemorrhage 81.22 12.68 102 169432 9655 79565199
Lymphocyte count decreased 81.09 12.68 253 169281 47036 79527818
Anastomotic fistula 80.02 12.68 24 169510 126 79574728
Anastomotic complication 79.93 12.68 32 169502 438 79574416
Fistula 79.91 12.68 117 169417 12823 79562031
Lactic acidosis 79.90 12.68 25 169509 70334 79504520
Pyrexia 79.74 12.68 1946 167588 676763 78898091
Metastasis 79.23 12.68 85 169449 6795 79568059
Wrong technique in product usage process 79.11 12.68 29 169505 73846 79501008
Oesophagobronchial fistula 78.96 12.68 27 169507 229 79574625
Paronychia 78.75 12.68 90 169444 7718 79567136
Malignant ascites 78.47 12.68 42 169492 1150 79573704
Osteoarthritis 78.34 12.68 44 169490 87265 79487589
Contusion 78.18 12.68 122 169412 148654 79426200
Macular hole 77.74 12.68 37 169497 784 79574070
Haemoptysis 77.74 12.68 279 169255 55720 79519134
Urogenital fistula 77.63 12.68 24 169510 142 79574712
Enteritis 77.53 12.68 123 169411 14460 79560394
Hyperammonaemia 76.91 12.68 106 169428 10987 79563867
Ciliary hyperaemia 76.80 12.68 20 169514 55 79574799
Injection site pruritus 76.72 12.68 3 169531 42280 79532574
Plasma cell myeloma 76.61 12.68 11 169523 53248 79521606
Haemorrhage 76.04 12.68 389 169145 90729 79484125
Tumour rupture 75.91 12.68 31 169503 448 79574406
Immune thrombocytopenia 75.82 12.68 136 169398 17669 79557185
Stomal varices 75.66 12.68 21 169513 79 79574775
Acute abdomen 74.13 12.68 58 169476 3079 79571775
Blindness 73.86 12.68 177 169357 28206 79546648
Osteoporosis 73.73 12.68 13 169521 54099 79520755
Enterocutaneous fistula 73.46 12.68 48 169486 1913 79572941
Intentional product use issue 73.26 12.68 564 168970 151548 79423306
Cerebral ischaemia 73.19 12.68 104 169430 11091 79563763
Palpitations 72.24 12.68 98 169436 126512 79448342
Retinal oedema 72.07 12.68 37 169497 928 79573926
Hypothyroidism 71.85 12.68 260 169274 52132 79522722
Hypopyon 71.72 12.68 39 169495 1103 79573751
Pseudocirrhosis 71.67 12.68 33 169501 647 79574207
Fistula of small intestine 71.45 12.68 35 169499 792 79574062
Drug level increased 71.31 12.68 3 169531 39648 79535206
Asthenia 70.90 12.68 1502 168032 510187 79064667
Somnolence 70.76 12.68 265 169269 238716 79336138
Treatment noncompliance 70.26 12.68 13 169521 52255 79522599
Cerebral infarction 69.85 12.68 235 169299 45441 79529413
Macular fibrosis 69.74 12.68 33 169501 690 79574164
Adverse event 69.09 12.68 21 169513 60193 79514661
Hallucination 68.97 12.68 49 169485 85696 79489158
Perforation 68.82 12.68 41 169493 1385 79573469
Carbohydrate antigen 125 increased 68.77 12.68 48 169486 2136 79572718
Migraine 67.78 12.68 52 169482 87441 79487413
Prescribed overdose 67.69 12.68 3 169531 37880 79536974
Duodenal ulcer perforation 67.58 12.68 28 169506 66183 79508671
Product prescribing error 67.48 12.68 8 169526 44805 79530049
Osteonecrosis 67.45 12.68 181 169353 30914 79543940
Retinal disorder 66.83 12.68 46 169488 2001 79572853
Pneumatosis intestinalis 66.67 12.68 75 169459 6322 79568532
Aggression 65.72 12.68 14 169520 50944 79523910
Abdominal abscess 64.97 12.68 78 169456 7049 79567805
Tremor 64.92 12.68 168 169366 169915 79404939
Sleep apnoea syndrome 64.81 12.68 3 169531 36475 79538379
Malignant glioma 64.69 12.68 17 169517 49 79574805
Drug dependence 64.67 12.68 6 169528 40763 79534091
Chronic obstructive pulmonary disease 64.62 12.68 52 169482 85367 79489487
Ovarian cancer recurrent 64.49 12.68 27 169507 417 79574437
Agitation 64.49 12.68 70 169464 99645 79475209
Hypoalbuminaemia 64.48 12.68 141 169393 21156 79553698
Fluid retention 64.35 12.68 34 169500 69775 79505079
Tracheal fistula 63.84 12.68 21 169513 156 79574698
Arteriospasm coronary 63.70 12.68 75 169459 6641 79568213
Psychotic disorder 63.32 12.68 7 169527 41395 79533459
Pneumonitis 63.31 12.68 277 169257 60583 79514271
Colitis 63.29 12.68 316 169218 72991 79501863
Angioedema 63.09 12.68 42 169492 75993 79498861
Leukoencephalopathy 63.01 12.68 81 169453 7848 79567006
Cardiac failure congestive 62.94 12.68 130 169404 142272 79432582
Hypoglycaemia 62.78 12.68 74 169460 101520 79473334
Malignant pleural effusion 62.10 12.68 54 169480 3326 79571528
Metastatic neoplasm 61.09 12.68 64 169470 4978 79569876
Anal fistula 60.06 12.68 74 169460 6870 79567984
Inappropriate schedule of product administration 59.89 12.68 121 169413 133507 79441347
Accidental overdose 59.76 12.68 7 169527 39574 79535280
Muscle spasms 59.01 12.68 183 169351 174547 79400307
Rash 58.65 12.68 871 168663 577487 78997367
Tumour marker increased 58.63 12.68 58 169476 4214 79570640
Vitreous detachment 58.27 12.68 44 169490 2215 79572639
Colorectal cancer metastatic 58.20 12.68 35 169499 1203 79573651
Lymphangiosis carcinomatosa 57.89 12.68 43 169491 2111 79572743
Laryngeal necrosis 57.54 12.68 14 169520 26 79574828
Hemiparesis 57.40 12.68 180 169354 33553 79541301
Pantoea agglomerans infection 57.37 12.68 17 169517 85 79574769
Hypotension 57.30 12.68 629 168905 439688 79135166
Product use in unapproved indication 57.02 12.68 306 169228 250053 79324801
Type 2 diabetes mellitus 56.95 12.68 25 169509 57097 79517757
Blood bilirubin increased 56.82 12.68 285 169249 65947 79508907
Macular ischaemia 56.57 12.68 17 169517 90 79574764
Gastrointestinal anastomotic leak 55.82 12.68 26 169508 524 79574330
Enterocolitis 55.70 12.68 106 169428 14406 79560448
Cataract nuclear 55.56 12.68 32 169502 1014 79573840
Injection site bruising 55.53 12.68 10 169524 40992 79533862
Drug withdrawal syndrome 55.36 12.68 5 169529 34713 79540141
Hip arthroplasty 54.80 12.68 6 169528 35750 79539104
Stress 54.75 12.68 53 169481 79559 79495295
Retinal vascular disorder 54.50 12.68 22 169512 308 79574546
Coma 54.34 12.68 81 169453 100568 79474286
Failure to anastomose 54.21 12.68 20 169514 216 79574638
Medication error 54.19 12.68 40 169494 68602 79506252
Acute myeloid leukaemia 53.65 12.68 166 169368 30719 79544135
Obesity 53.56 12.68 6 169528 35119 79539735
Transmission of an infectious agent via product 53.53 12.68 19 169515 182 79574672
Pulmonary haemorrhage 53.43 12.68 105 169429 14612 79560242
Gait disturbance 53.36 12.68 243 169291 207263 79367591
Adverse drug reaction 53.31 12.68 38 169496 66354 79508500
Metastases to pleura 53.29 12.68 36 169498 1518 79573336
Red cell distribution width increased 53.24 12.68 107 169427 15135 79559719
Gastrointestinal necrosis 52.54 12.68 62 169472 5503 79569351
Dyskinesia 52.49 12.68 15 169519 44758 79530096
Nail toxicity 52.48 12.68 22 169512 341 79574513
Oesophagitis 52.30 12.68 141 169393 24148 79550706
Headache 52.23 12.68 1028 168506 652744 78922110
Illness 51.97 12.68 17 169517 46494 79528360
Enterovesical fistula 51.93 12.68 32 169502 1150 79573704
Swelling face 51.83 12.68 45 169489 71167 79503687
Metamorphopsia 51.77 12.68 33 169501 1260 79573594
Respiratory arrest 51.63 12.68 29 169505 57521 79517333
Hypomagnesaemia 51.47 12.68 217 169317 46694 79528160
Retinal exudates 50.64 12.68 32 169502 1203 79573651
Hypophosphataemia 50.54 12.68 123 169411 19790 79555064
Device related infection 50.29 12.68 174 169360 34120 79540734
Eosinophilia 49.92 12.68 17 169517 45328 79529526
Folliculitis 49.55 12.68 28 169506 55352 79519502
Performance status decreased 49.45 12.68 63 169471 6050 79568804
Nasal congestion 49.21 12.68 54 169480 76498 79498356
Burning sensation 49.16 12.68 32 169502 58600 79516254
Joint stiffness 49.14 12.68 13 169521 40817 79534037
Magnetic resonance imaging head abnormal 48.98 12.68 43 169491 2683 79572171
Glioblastoma 48.83 12.68 35 169499 1625 79573229
Peritoneal disorder 48.67 12.68 26 169508 709 79574145
Toxic epidermal necrolysis 48.58 12.68 17 169517 44564 79530290
Injection site reaction 48.58 12.68 28 169506 54757 79520097
Thrombophlebitis migrans 48.08 12.68 22 169512 425 79574429
Dry throat 48.05 12.68 70 169464 7636 79567218
Vitreous opacities 47.88 12.68 25 169509 650 79574204
Superior vena cava syndrome 47.84 12.68 31 169503 1218 79573636
Irritability 47.84 12.68 14 169520 41130 79533724
Mucosal toxicity 47.71 12.68 24 169510 576 79574278
Cholecystitis acute 47.67 12.68 95 169439 13356 79561498
Retinal artery occlusion 47.59 12.68 46 169488 3248 79571606
Ear infection 47.50 12.68 8 169526 34424 79540430
Underdose 47.32 12.68 7 169527 33144 79541710
Bleeding varicose vein 47.00 12.68 24 169510 595 79574259
Hypertensive encephalopathy 46.78 12.68 28 169506 954 79573900
Incisional hernia 46.25 12.68 40 169494 2446 79572408
Therapy interrupted 46.20 12.68 6 169528 31335 79543519
Memory impairment 46.06 12.68 106 169428 111628 79463226
Pneumoperitoneum 46.04 12.68 44 169490 3064 79571790
Mycotic endophthalmitis 45.96 12.68 17 169517 185 79574669
Anterior chamber inflammation 45.76 12.68 23 169511 551 79574303
Prostate cancer 45.30 12.68 8 169526 33260 79541594
Mean cell volume increased 45.24 12.68 61 169473 6192 79568662
Rectal haemorrhage 44.90 12.68 297 169237 76003 79498851
Proctalgia 44.66 12.68 78 169456 9923 79564931
Perirectal abscess 44.51 12.68 36 169498 2005 79572849
Colon cancer metastatic 44.49 12.68 37 169497 2144 79572710
Ovarian cancer metastatic 44.05 12.68 23 169511 598 79574256
Respiratory depression 44.00 12.68 4 169530 27626 79547228
Throat tightness 43.93 12.68 145 169389 27762 79547092
Eczema 43.74 12.68 16 169518 40802 79534052
Blood pressure fluctuation 43.56 12.68 47 169487 67098 79507756
Acral peeling skin syndrome 43.48 12.68 12 169522 44 79574810
Therapy cessation 43.27 12.68 13 169521 37549 79537305
Nightmare 43.26 12.68 3 169531 25858 79548996
Therapeutic product effect incomplete 43.26 12.68 155 169379 141490 79433364
Mechanical ileus 43.25 12.68 26 169508 893 79573961
Hypokalaemia 42.96 12.68 482 169052 143558 79431296
Basal cell carcinoma 42.94 12.68 13 169521 37362 79537492
Pregnancy 42.46 12.68 4 169530 26847 79548007
Pulmonary artery thrombosis 42.45 12.68 30 169504 1362 79573492
Left ventricular dysfunction 42.30 12.68 113 169421 19248 79555606
Lip swelling 42.24 12.68 17 169517 40894 79533960
Poisoning 42.08 12.68 3 169531 25269 79549585
Tumour ulceration 41.73 12.68 17 169517 244 79574610
Intestinal metastasis 41.52 12.68 19 169515 367 79574487
Myoclonus 41.49 12.68 5 169529 27655 79547199
Intracranial tumour haemorrhage 41.37 12.68 21 169513 514 79574340
Upper respiratory tract infection 41.32 12.68 82 169452 91086 79483768
Rash pruritic 41.30 12.68 55 169479 71574 79503280
Cardiac arrest 41.05 12.68 207 169327 171889 79402965
Pelvic abscess 40.84 12.68 35 169499 2114 79572740
Choroidal neovascularisation 40.77 12.68 20 169514 454 79574400
Prescribed underdose 40.40 12.68 7 169527 29507 79545347
Abortion spontaneous 40.39 12.68 7 169527 29500 79545354
Metabolic acidosis 40.25 12.68 71 169463 82458 79492396
Foot deformity 39.68 12.68 3 169531 24071 79550783
Gastric disorder 39.56 12.68 15 169519 37418 79537436
Eye discharge 39.36 12.68 56 169478 5978 79568876
Splenomegaly 39.30 12.68 115 169419 20639 79554215
Joint range of motion decreased 39.29 12.68 11 169523 33271 79541583
Mean cell haemoglobin increased 39.23 12.68 47 169487 4238 79570616
Road traffic accident 39.17 12.68 22 169512 43642 79531212
Haemoglobin 39.13 12.68 13 169521 100 79574754
Radiation necrosis 38.95 12.68 19 169515 426 79574428
Swollen tongue 38.84 12.68 21 169513 42549 79532305
Angiogram retina abnormal 38.80 12.68 9 169525 12 79574842
Ejection fraction decreased 38.75 12.68 161 169373 34416 79540438
Wound infection 38.07 12.68 125 169409 23866 79550988
Device issue 38.07 12.68 6 169528 27102 79547752
Coronary artery disease 38.03 12.68 50 169484 65424 79509430
Lower limb fracture 37.96 12.68 3 169531 23212 79551642
Obstructive airways disorder 37.89 12.68 10 169524 31449 79543405
Non-infectious endophthalmitis 37.84 12.68 17 169517 314 79574540
Abnormal behaviour 37.82 12.68 15 169519 36406 79538448
Joint injury 37.66 12.68 10 169524 31325 79543529
Hypervolaemia 37.59 12.68 22 169512 42668 79532186
Granulocyte count decreased 37.56 12.68 31 169503 1777 79573077
Hepatic encephalopathy 37.54 12.68 125 169409 24041 79550813
Emotional distress 37.53 12.68 19 169515 39950 79534904
Intraocular pressure increased 37.53 12.68 69 169465 9136 79565718
Bronchial fistula 37.49 12.68 15 169519 205 79574649
Sciatica 37.37 12.68 12 169522 33210 79541644
Ureteric compression 37.09 12.68 16 169518 267 79574587
Pulpitis dental 37.06 12.68 27 169507 1286 79573568
Visual impairment 37.03 12.68 328 169206 91803 79483051
Labelled drug-drug interaction medication error 36.90 12.68 7 169527 27643 79547211
Arterioenteric fistula 36.23 12.68 9 169525 19 79574835
Cyclitis 36.09 12.68 7 169527 0 79574854
Acute kidney injury 36.09 12.68 835 168699 518569 79056285
Diabetes mellitus 35.96 12.68 70 169464 78320 79496534
Myalgia 35.86 12.68 239 169295 185402 79389452
Unresponsive to stimuli 35.15 12.68 40 169494 55748 79519106
Colitis ulcerative 34.96 12.68 15 169519 34727 79540127
Venoocclusive liver disease 34.58 12.68 77 169457 11694 79563160
Hyperhidrosis 34.56 12.68 185 169349 151307 79423547
Subretinal fibrosis 34.55 12.68 13 169521 149 79574705
Diverticular perforation 34.54 12.68 52 169482 5841 79569013
Extravasation 34.12 12.68 41 169493 3709 79571145
Gastrooesophageal reflux disease 33.91 12.68 111 169423 104135 79470719
Pneumonia 33.85 12.68 1108 168426 659138 78915716
Fatigue 33.84 12.68 2351 167183 927376 78647478
Urinary tract obstruction 33.74 12.68 46 169488 4719 79570135
Bursitis 33.71 12.68 17 169517 35827 79539027
Blood glucose increased 33.67 12.68 128 169406 114847 79460007
Rectourethral fistula 33.60 12.68 7 169527 3 79574851
Microangiopathic haemolytic anaemia 33.44 12.68 27 169507 1500 79573354
Retinal degeneration 33.41 12.68 25 169509 1241 79573613
Retinal vascular occlusion 33.39 12.68 19 169515 588 79574266
Urinary occult blood 33.18 12.68 8 169526 14 79574840
Ureteric fistula 33.18 12.68 8 169526 14 79574840
Sleep disorder 33.16 12.68 84 169450 85593 79489261
Blindness unilateral 33.13 12.68 61 169473 8085 79566769
Myelodysplastic syndrome 33.11 12.68 140 169394 30161 79544693
Therapy responder 32.77 12.68 17 169517 436 79574418
Nervousness 32.72 12.68 15 169519 33400 79541454
Infectious pleural effusion 32.54 12.68 40 169494 3704 79571150
EGFR gene mutation 32.38 12.68 17 169517 447 79574407
Productive cough 32.36 12.68 89 169445 88242 79486612
Loss of consciousness 32.04 12.68 217 169317 167726 79407128
Dysaesthesia 32.02 12.68 50 169484 5798 79569056
Peritoneal neoplasm 31.99 12.68 11 169523 95 79574759
Macular scar 31.99 12.68 11 169523 95 79574759
Cystitis radiation 31.95 12.68 13 169521 186 79574668
Colitis ischaemic 31.91 12.68 88 169446 15271 79559583
Neutropenic sepsis 31.90 12.68 128 169406 26936 79547918
Neoplasm recurrence 31.85 12.68 42 169492 4172 79570682
Diabetic retinopathy 31.66 12.68 36 169498 3070 79571784
Colonic fistula 31.60 12.68 19 169515 653 79574201
Thrombotic thrombocytopenic purpura 31.47 12.68 52 169482 6324 79568530
Adrenocorticotropic hormone deficiency 31.42 12.68 25 169509 1360 79573494
Right ventricular failure 31.24 12.68 6 169528 23491 79551363
Ventricular tachycardia 31.13 12.68 26 169508 41909 79532945
Throat irritation 30.87 12.68 25 169509 40921 79533933
Acute coronary syndrome 30.79 12.68 107 169427 21026 79553828
Microangiopathy 30.70 12.68 28 169506 1837 79573017
Hyperbilirubinaemia 30.55 12.68 118 169416 24400 79550454
Procedural pain 30.47 12.68 6 169528 23078 79551776
Anaemia of malignant disease 30.43 12.68 20 169514 805 79574049
Crying 30.40 12.68 6 169528 23037 79551817
Disturbance in attention 30.32 12.68 38 169496 50763 79524091
Abdominal infection 30.31 12.68 38 169496 3591 79571263
Embolism venous 30.13 12.68 41 169493 4198 79570656
Glycosylated haemoglobin increased 30.11 12.68 3 169531 19257 79555597
Immune-mediated hepatitis 30.08 12.68 38 169496 3618 79571236
Hiccups 29.90 12.68 66 169468 9965 79564889
Adenocarcinoma 29.79 12.68 39 169495 3847 79571007
Nephrolithiasis 29.63 12.68 42 169492 53249 79521605
Muscle spasticity 29.60 12.68 5 169529 21470 79553384
Thrombosis 29.57 12.68 291 169243 83809 79491045
Product substitution issue 29.56 12.68 4 169530 20252 79554602
Dystonia 29.46 12.68 5 169529 21394 79553460
Hypoferritinaemia 28.77 12.68 7 169527 13 79574841
Anal haemorrhage 28.66 12.68 40 169494 4194 79570660
Melanoderma 28.55 12.68 15 169519 395 79574459
Herpes zoster 28.32 12.68 102 169432 92981 79481873
Autoimmune haemolytic anaemia 28.28 12.68 58 169476 8322 79566532
Onycholysis 28.07 12.68 28 169506 2055 79572799
Transplant rejection 27.99 12.68 4 169530 19433 79555421
Product contamination microbial 27.95 12.68 20 169514 926 79573928
Retinal scar 27.95 12.68 15 169519 413 79574441
Anterior chamber cell 27.90 12.68 20 169514 929 79573925
Ocular discomfort 27.84 12.68 43 169491 4940 79569914
Full blood count abnormal 27.76 12.68 27 169507 40447 79534407
Glomerulonephritis membranoproliferative 27.71 12.68 17 169517 606 79574248
Metastases to ovary 27.57 12.68 14 169520 343 79574511
Thyroiditis 27.51 12.68 41 169493 4564 79570290
Limb discomfort 27.44 12.68 18 169516 32832 79542022
Gastric varices haemorrhage 27.43 12.68 15 169519 429 79574425
Transfusion 27.22 12.68 6 169528 21324 79553530
Vaginal fistula 27.16 12.68 13 169521 279 79574575
Tumour thrombosis 27.06 12.68 11 169523 157 79574697
Localised infection 27.03 12.68 24 169510 37551 79537303
Chest discomfort 27.02 12.68 177 169357 137867 79436987
Vena cava thrombosis 26.91 12.68 32 169502 2863 79571991
Gastrointestinal fistula 26.81 12.68 18 169516 751 79574103
Oesophageal fistula 26.66 12.68 15 169519 454 79574400
Duodenal ulcer 26.62 12.68 86 169448 16283 79558571
Vascular pseudoaneurysm 26.56 12.68 35 169499 3475 79571379
Metastases to spine 26.56 12.68 39 169495 4285 79570569
Rectal cancer metastatic 26.46 12.68 15 169519 461 79574393
Febrile bone marrow aplasia 26.45 12.68 74 169460 12946 79561908
Cytomegalovirus infection 26.40 12.68 31 169503 42613 79532241
Blindness transient 26.38 12.68 41 169493 4735 79570119
Post procedural fistula 26.27 12.68 13 169521 301 79574553
Infected lymphocele 26.21 12.68 12 169522 232 79574622
Retinal neovascularisation 26.21 12.68 11 169523 171 79574683
Neck pain 26.15 12.68 78 169456 75339 79499515
Uveitis 26.09 12.68 87 169447 16743 79558111
Tumour invasion 26.07 12.68 14 169520 386 79574468
Rectal ulcer 26.01 12.68 27 169507 2077 79572777
Metastases to adrenals 25.97 12.68 22 169512 1308 79573546
Pseudoendophthalmitis 25.92 12.68 8 169526 47 79574807
Hypopituitarism 25.88 12.68 34 169500 3365 79571489
Extrapyramidal disorder 25.85 12.68 8 169526 22671 79552183
Venous pressure jugular decreased 25.75 12.68 9 169525 82 79574772
Oligoastrocytoma 25.72 12.68 7 169527 24 79574830
Hepatic lesion 25.69 12.68 50 169484 6909 79567945
Exostosis 25.40 12.68 3 169531 16855 79557999
Metastases to abdominal wall 25.37 12.68 11 169523 186 79574668
Infusion related reaction 25.29 12.68 341 169193 229896 79344958
Liver carcinoma ruptured 25.26 12.68 11 169523 188 79574666
Hypophagia 25.13 12.68 174 169360 45193 79529661
Amnesia 25.04 12.68 61 169473 62996 79511858
Cardio-respiratory arrest 25.03 12.68 132 169402 108378 79466476
Mental disorder 25.02 12.68 18 169516 31284 79543570
Gastric varices 25.02 12.68 17 169517 724 79574130
Confusional state 25.01 12.68 501 169033 317496 79257358
Haemolytic anaemia 24.91 12.68 89 169445 17731 79557123
Tumour hyperprogression 24.90 12.68 11 169523 195 79574659
Toxic anterior segment syndrome 24.79 12.68 30 169504 2734 79572120
Retinal aneurysm 24.72 12.68 12 169522 266 79574588
Respiratory tract congestion 24.69 12.68 6 169528 19948 79554906
Acquired gene mutation 24.68 12.68 27 169507 2206 79572648
Hallucination, visual 24.65 12.68 20 169514 32709 79542145
Cutis laxa 24.65 12.68 10 169524 142 79574712
Metastases to kidney 24.60 12.68 15 169519 529 79574325
Peripheral motor neuropathy 24.59 12.68 33 169501 3334 79571520
Mood swings 24.56 12.68 6 169528 19874 79554980
Conjunctival hyperaemia 24.54 12.68 38 169496 4375 79570479
Seasonal allergy 24.52 12.68 3 169531 16403 79558451
Biliary fistula 24.50 12.68 9 169525 96 79574758
Kidney infection 24.39 12.68 8 169526 21843 79553011
Fingerprint loss 24.37 12.68 8 169526 59 79574795
Bladder perforation 24.35 12.68 13 169521 354 79574500
Cardiogenic shock 24.35 12.68 32 169502 41882 79532972
Incorrect route of product administration 24.31 12.68 23 169511 34906 79539948
Gingival bleeding 24.23 12.68 83 169451 16193 79558661
Atypical haemolytic uraemic syndrome 24.21 12.68 19 169515 1013 79573841
Gastropleural fistula 24.14 12.68 8 169526 61 79574793
Hallucination, auditory 24.13 12.68 7 169527 20686 79554168
Jejunal perforation 24.06 12.68 13 169521 363 79574491
Progressive multifocal leukoencephalopathy 23.96 12.68 7 169527 20593 79554261
Tumour cavitation 23.96 12.68 7 169527 33 79574821
Rash macular 23.92 12.68 16 169518 28883 79545971
COVID-19 pneumonia 23.84 12.68 16 169518 28833 79546021
Pelvic infection 23.80 12.68 13 169521 371 79574483
Blood pressure increased 23.77 12.68 603 168931 210757 79364097
Device malfunction 23.68 12.68 8 169526 21440 79553414
Radiation oesophagitis 23.68 12.68 16 169518 675 79574179
Delusion 23.65 12.68 7 169527 20416 79554438
Frequent bowel movements 23.59 12.68 17 169517 29522 79545332
Disability 23.57 12.68 4 169530 17116 79557738
Embolism arterial 23.46 12.68 22 169512 1496 79573358
Duodenal varices 23.45 12.68 6 169528 15 79574839
Bronchopulmonary aspergillosis 23.45 12.68 9 169525 22285 79552569
Drug resistance 23.44 12.68 162 169372 42051 79532803
Device dislocation 23.42 12.68 13 169521 25957 79548897
Head injury 23.31 12.68 27 169507 37342 79537512
Ankle fracture 23.28 12.68 4 169530 16965 79557889
Tooth erosion 23.06 12.68 13 169521 395 79574459
Laryngospasm 23.05 12.68 35 169499 3962 79570892
C-reactive protein increased 23.00 12.68 170 169364 128857 79445997
Cardiac disorder 22.81 12.68 68 169466 65689 79509165
Tachyphylaxis 22.74 12.68 12 169522 319 79574535
Myocardial infarction 22.73 12.68 266 169268 183863 79390991
Grip strength decreased 22.72 12.68 9 169525 21860 79552994
Parkinsonism 22.55 12.68 4 169530 16580 79558274
Trichomegaly 22.49 12.68 9 169525 123 79574731
Respiratory disorder 22.41 12.68 38 169496 44818 79530036
Cardiotoxicity 22.40 12.68 67 169467 12172 79562682
Skin ulcer 22.38 12.68 194 169340 53956 79520898
Lacrimation increased 22.38 12.68 101 169433 22376 79552478
Pulmonary fibrosis 22.38 12.68 37 169497 44075 79530779
Hyperammonaemic encephalopathy 22.27 12.68 38 169496 4744 79570110
Device related thrombosis 22.26 12.68 28 169506 2655 79572199
Visual field defect 22.03 12.68 55 169479 8990 79565864
Type II hypersensitivity 22.02 12.68 7 169527 46 79574808
Panic attack 22.01 12.68 12 169522 24204 79550650
Bronchiectasis 22.00 12.68 10 169524 22376 79552478
Immune-mediated enterocolitis 21.99 12.68 38 169496 4792 79570062
Cerebral haemorrhage 21.98 12.68 203 169331 57470 79517384
Vitreoretinal traction syndrome 21.95 12.68 6 169528 21 79574833
Retinal vein occlusion 21.91 12.68 31 169503 3292 79571562
Blood pressure decreased 21.84 12.68 123 169411 99343 79475511
Night sweats 21.81 12.68 49 169485 52046 79522808
Delirium 21.80 12.68 99 169435 84528 79490326
Biliary tract disorder 21.75 12.68 22 169512 1642 79573212
Gallbladder disorder 21.73 12.68 7 169527 19333 79555521
Depressed mood 21.63 12.68 44 169490 48436 79526418
Gastroenteritis viral 21.58 12.68 13 169521 24818 79550036
Ocular hypertension 21.54 12.68 21 169513 1499 79573355
Rectal cancer recurrent 21.53 12.68 6 169528 23 79574831
Abdominal hernia 21.53 12.68 41 169493 5575 79569279
Pyelocaliectasis 21.51 12.68 17 169517 916 79573938
Short-bowel syndrome 21.49 12.68 14 169520 555 79574299
Gout 21.45 12.68 13 169521 24736 79550118
Liver function test abnormal 21.42 12.68 68 169466 64407 79510447
Stomal hernia 21.40 12.68 12 169522 361 79574493
Anal ulcer 21.35 12.68 20 169514 1358 79573496
Incarcerated incisional hernia 21.33 12.68 6 169528 24 79574830
Fear 21.33 12.68 10 169524 21976 79552878
Restless legs syndrome 21.32 12.68 8 169526 20084 79554770
Periodontitis 21.30 12.68 36 169498 4460 79570394
Dysaesthesia pharynx 21.22 12.68 10 169524 207 79574647
Neutropenic infection 21.21 12.68 26 169508 2401 79572453
Unevaluable event 21.12 12.68 55 169479 55530 79519324
BRCA2 gene mutation 21.08 12.68 8 169526 94 79574760
Heart rate increased 21.07 12.68 160 169374 120564 79454290
Therapeutic response unexpected 21.07 12.68 8 169526 19938 79554916
Polychromasia 20.95 12.68 12 169522 376 79574478
Portal hypertensive gastropathy 20.91 12.68 20 169514 1394 79573460
Restlessness 20.91 12.68 42 169492 46450 79528404
Anorectal disorder 20.75 12.68 25 169509 2268 79572586
Proteus infection 20.66 12.68 24 169510 2094 79572760
Oesophageal haemorrhage 20.64 12.68 22 169512 1745 79573109
Sneezing 20.61 12.68 8 169526 19675 79555179
Xeroderma 20.56 12.68 11 169523 301 79574553
Thrombophlebitis 20.39 12.68 43 169491 6292 79568562
Cytokine release syndrome 20.38 12.68 28 169506 35970 79538884
Lip dry 20.37 12.68 4 169530 15414 79559440
Aneurysm 20.36 12.68 31 169503 3517 79571337
Hot flush 20.32 12.68 55 169479 54822 79520032
Splenic artery thrombosis 20.30 12.68 7 169527 61 79574793
Haemolytic uraemic syndrome 20.26 12.68 35 169499 4414 79570440
Prothrombin level decreased 20.15 12.68 21 169513 1623 79573231
Ophthalmological examination abnormal 20.11 12.68 7 169527 63 79574791
Cholecystitis 20.06 12.68 97 169437 22115 79552739
Pulmonary cavitation 20.03 12.68 21 169513 1635 79573219
Encephalitis 20.02 12.68 73 169461 14687 79560167
Oropharyngeal pain 20.01 12.68 143 169391 109210 79465644
Detachment of macular retinal pigment epithelium 19.99 12.68 5 169529 11 79574843
Torsade de pointes 19.98 12.68 8 169526 19304 79555550
Haemobilia 19.97 12.68 13 169521 515 79574339
Injection related reaction 19.95 12.68 17 169517 1019 79573835
Limb injury 19.90 12.68 20 169514 29508 79545346
Perihepatic abscess 19.90 12.68 9 169525 169 79574685
Ileus paralytic 19.87 12.68 55 169479 9565 79565289
Foot fracture 19.82 12.68 11 169523 21970 79552884
Acute generalised exanthematous pustulosis 19.82 12.68 6 169528 17248 79557606
Tongue geographic 19.82 12.68 7 169527 66 79574788
Wound complication 19.82 12.68 37 169497 4956 79569898
Anorectal infection 19.76 12.68 12 169522 420 79574434
Rash papular 19.72 12.68 11 169523 21905 79552949
Dysstasia 19.63 12.68 18 169516 27728 79547126
Choroidal infarction 19.61 12.68 9 169525 175 79574679
Influenza like illness 19.61 12.68 82 169452 71625 79503229
Blood potassium increased 19.54 12.68 20 169514 29255 79545599
Mental impairment 19.50 12.68 8 169526 19028 79555826
Heart rate decreased 19.49 12.68 80 169454 70236 79504618
Vitreous disorder 19.47 12.68 10 169524 251 79574603
Ulcerative keratitis 19.45 12.68 31 169503 3658 79571196
Respiratory tract infection 19.41 12.68 47 169487 48642 79526212
Joint effusion 19.40 12.68 7 169527 18007 79556847
Charles Bonnet syndrome 19.40 12.68 5 169529 13 79574841
Anhedonia 19.40 12.68 4 169530 14894 79559960
Pulmonary arterial hypertension 19.37 12.68 19 169515 28347 79546507
Iridocyclitis 19.36 12.68 31 169503 3673 79571181
Pulmonary fistula 19.28 12.68 7 169527 72 79574782
Enterocolitis infectious 19.27 12.68 27 169507 2842 79572012
Bronchopleural fistula 19.25 12.68 14 169520 665 79574189
Paraneoplastic dermatomyositis 19.19 12.68 7 169527 73 79574781
Hiatus hernia 19.17 12.68 13 169521 23299 79551555
Accidental exposure to product 19.15 12.68 23 169511 31299 79543555
Tinnitus 19.13 12.68 41 169493 44292 79530562
Gene mutation 19.12 12.68 26 169508 2660 79572194
Haematocrit decreased 19.11 12.68 207 169327 61105 79513749
Surgery 19.05 12.68 25 169509 32741 79542113
International normalised ratio increased 19.01 12.68 104 169430 84617 79490237
Myocarditis 18.97 12.68 94 169440 21639 79553215
Carbohydrate antigen 19-9 increased 18.95 12.68 12 169522 453 79574401
Sepsis 18.94 12.68 726 168808 268702 79306152
Metastases to gastrointestinal tract 18.91 12.68 8 169526 127 79574727
Bone marrow disorder 18.89 12.68 29 169505 3314 79571540
Bladder cancer 18.76 12.68 9 169525 19517 79555337
Seizure 18.73 12.68 530 169004 188304 79386550
Skin disorder 18.69 12.68 130 169404 33813 79541041
Sudden death 18.69 12.68 96 169438 22415 79552439
Abdominal wound dehiscence 18.64 12.68 10 169524 275 79574579
Metastases to vagina 18.64 12.68 5 169529 16 79574838
Bone density decreased 18.64 12.68 3 169531 13344 79561510
Bladder tamponade 18.61 12.68 13 169521 579 79574275
Blood glucose decreased 18.58 12.68 17 169517 26217 79548637
Aphasia 18.58 12.68 166 169368 46566 79528288
Cancer pain 18.53 12.68 37 169497 5208 79569646
Vitreous adhesions 18.43 12.68 6 169528 43 79574811
Appendicitis noninfective 18.41 12.68 5 169529 17 79574837
Tracheo-oesophageal fistula 18.34 12.68 13 169521 593 79574261
Concomitant disease aggravated 18.29 12.68 3 169531 13164 79561690
Gait inability 18.29 12.68 64 169470 58853 79516001
Epilepsy 18.27 12.68 149 169385 40711 79534143
Peripheral sensorimotor neuropathy 18.27 12.68 27 169507 2983 79571871
Primary adrenal insufficiency 18.20 12.68 9 169525 208 79574646
Immune-mediated pancreatitis 18.19 12.68 10 169524 289 79574565
Exudative retinopathy 18.19 12.68 5 169529 18 79574836
Pelvic venous thrombosis 18.11 12.68 23 169511 2202 79572652
Chronic sinusitis 18.03 12.68 3 169531 13023 79561831
Hypokinesia 17.98 12.68 9 169525 19051 79555803
Chemotherapy cardiotoxicity attenuation 17.98 12.68 5 169529 19 79574835
Inflammation 17.94 12.68 121 169413 93632 79481222
Periodontal disease 17.93 12.68 21 169513 1849 79573005
Hypertransaminasaemia 17.92 12.68 61 169473 11863 79562991
Eye pain 17.88 12.68 139 169395 37439 79537415
Aortic thrombosis 17.88 12.68 20 169514 1675 79573179
IIIrd nerve paralysis 17.88 12.68 17 169517 1176 79573678
Subclavian vein thrombosis 17.82 12.68 24 169510 2433 79572421
Macular detachment 17.82 12.68 9 169525 218 79574636
Skin striae 17.77 12.68 21 169513 1867 79572987
Fungal infection 17.69 12.68 39 169495 41709 79533145
Hypercreatinaemia 17.62 12.68 10 169524 308 79574546
Impaired healing 17.62 12.68 273 169261 87382 79487472
Glomerulonephropathy 17.59 12.68 10 169524 309 79574545
Soft tissue necrosis 17.59 12.68 15 169519 900 79573954
Inferior vena cava stenosis 17.54 12.68 6 169528 51 79574803
Lupus-like syndrome 17.48 12.68 4 169530 13853 79561001
Orthostatic hypotension 17.44 12.68 61 169473 56103 79518751
Cellulitis 17.44 12.68 148 169386 108912 79465942
Retinal depigmentation 17.41 12.68 10 169524 315 79574539
Tendonitis 17.41 12.68 15 169519 23815 79551039
Retinal ischaemia 17.40 12.68 14 169520 774 79574080
Periphlebitis 17.39 12.68 5 169529 22 79574832
Urine protein/creatinine ratio increased 17.39 12.68 17 169517 1217 79573637
Carpal tunnel syndrome 17.28 12.68 10 169524 19518 79555336
Metastases to abdominal cavity 17.28 12.68 13 169521 651 79574203
Subdural haematoma 17.25 12.68 25 169509 31409 79543445
Induration 17.20 12.68 21 169513 1931 79572923
Post procedural bile leak 17.19 12.68 11 169523 423 79574431
Rectal abscess 17.18 12.68 22 169512 2123 79572731
Intestinal strangulation 17.14 12.68 6 169528 55 79574799
Laryngeal leukoplakia 17.14 12.68 6 169528 55 79574799
Liver abscess 17.11 12.68 39 169495 6015 79568839
Abscess 17.10 12.68 95 169439 22856 79551998
Stevens-Johnson syndrome 17.09 12.68 36 169498 39130 79535724
Hemiplegia 17.09 12.68 70 169464 14869 79559985
Photosensitivity reaction 17.08 12.68 12 169522 21115 79553739
Aneurysm ruptured 17.04 12.68 15 169519 939 79573915
Atrioventricular block first degree 17.02 12.68 3 169531 12488 79562366
Skin lesion 16.99 12.68 40 169494 41804 79533050
Metastases to rectum 16.97 12.68 4 169530 6 79574848
Serous cystadenocarcinoma ovary 16.97 12.68 4 169530 6 79574848
Intestinal fistula 16.97 12.68 18 169516 1420 79573434
Secondary cerebellar degeneration 16.95 12.68 6 169528 57 79574797
Blood triglycerides increased 16.95 12.68 12 169522 21028 79553826
Pelvic fluid collection 16.93 12.68 14 169520 805 79574049
Cardiomyopathy 16.92 12.68 112 169422 28662 79546192
Anal abscess 16.92 12.68 51 169483 9304 79565550
Dysgeusia 16.88 12.68 191 169343 56986 79517868
Anal fissure 16.87 12.68 45 169489 7658 79567196
Hypermutation 16.86 12.68 6 169528 58 79574796
Lymphoma 16.84 12.68 8 169526 17452 79557402
Viral infection 16.78 12.68 42 169492 42974 79531880
Appendicitis perforated 16.69 12.68 27 169507 3226 79571628
Hypersensitivity 16.68 12.68 427 169107 261812 79313042
Peripheral paralysis 16.66 12.68 8 169526 173 79574681
Bile duct stenosis 16.66 12.68 21 169513 1995 79572859
Rales 16.65 12.68 11 169523 19990 79554864
Optic neuropathy 16.64 12.68 28 169506 3456 79571398
Erythema multiforme 16.60 12.68 78 169456 17573 79557281
Jaundice 16.57 12.68 180 169354 53169 79521685
Drug level decreased 16.56 12.68 5 169529 14397 79560457
Catheter site injury 16.54 12.68 9 169525 255 79574599
Cholangitis sclerosing 16.51 12.68 24 169510 2613 79572241
Necrosis 16.46 12.68 51 169483 9442 79565412
Pulmonary congestion 16.46 12.68 20 169514 27080 79547774
Depressed level of consciousness 16.44 12.68 129 169405 96523 79478331
Creatinine renal clearance decreased 16.44 12.68 10 169524 18992 79555862
Hypertriglyceridaemia 16.43 12.68 62 169472 12678 79562176
Atrophy of globe 16.41 12.68 6 169528 63 79574791
Skin burning sensation 16.40 12.68 4 169530 13268 79561586
Hypersplenism 16.39 12.68 12 169522 576 79574278
Anger 16.35 12.68 8 169526 17154 79557700
Lymphocele 16.32 12.68 19 169515 1662 79573192
Musculoskeletal disorder 16.29 12.68 13 169521 21435 79553419
Vitreous degeneration 16.26 12.68 5 169529 29 79574825
Eczema impetiginous 16.26 12.68 5 169529 29 79574825
Pelvic neoplasm 16.22 12.68 7 169527 117 79574737
Meningitis 16.18 12.68 51 169483 9531 79565323
Hyperlipidaemia 16.12 12.68 19 169515 26074 79548780
Iris neovascularisation 16.08 12.68 6 169528 67 79574787
Birdshot chorioretinopathy 16.08 12.68 6 169528 67 79574787
Haematemesis 16.08 12.68 176 169358 52088 79522766
Posterior capsule opacification 16.06 12.68 8 169526 188 79574666
Heart rate irregular 16.03 12.68 28 169506 32651 79542203
Jugular vein thrombosis 16.02 12.68 32 169502 4506 79570348
Haemoglobin decreased 15.96 12.68 600 168934 221519 79353335
Skin cancer 15.94 12.68 6 169528 15034 79559820
Bone pain 15.92 12.68 185 169349 55557 79519297
Cough 15.90 12.68 628 168906 366161 79208693
Product administration error 15.89 12.68 27 169507 31819 79543035
Intestinal ischaemia 15.83 12.68 63 169471 13207 79561647
Metastases to skin 15.80 12.68 19 169515 1720 79573134
Diabetic foot 15.79 12.68 28 169506 3604 79571250
Congestive cardiomyopathy 15.76 12.68 58 169476 11722 79563132
Retinopathy proliferative 15.75 12.68 7 169527 126 79574728
Type 1 diabetes mellitus 15.74 12.68 41 169493 6878 79567976
Diabetes mellitus inadequate control 15.72 12.68 17 169517 24247 79550607
Oxygen saturation decreased 15.70 12.68 187 169347 128860 79445994
Mydriasis 15.67 12.68 9 169525 17634 79557220
Colon cancer recurrent 15.65 12.68 7 169527 128 79574726
Dry age-related macular degeneration 15.60 12.68 9 169525 286 79574568
Spinal stenosis 15.60 12.68 7 169527 15784 79559070
Intervertebral disc degeneration 15.59 12.68 7 169527 15778 79559076
Iron deficiency anaemia 15.53 12.68 19 169515 25653 79549201
Biliary dilatation 15.51 12.68 24 169510 2762 79572092
Cytoreductive surgery 15.47 12.68 3 169531 0 79574854
Instillation site complication 15.47 12.68 3 169531 0 79574854
Choroidal rupture 15.47 12.68 3 169531 0 79574854
Oedema peripheral 15.46 12.68 413 169121 251875 79322979
Hypophysitis 15.46 12.68 30 169504 4136 79570718
Autoimmune disorder 15.44 12.68 8 169526 16604 79558250
Pharyngeal oedema 15.37 12.68 72 169462 16200 79558654
Transaminases 15.34 12.68 6 169528 77 79574777
Skin hyperpigmentation 15.33 12.68 42 169492 7261 79567593
Neutrophil count 15.32 12.68 8 169526 208 79574646
Skin discolouration 15.29 12.68 41 169493 40993 79533861
Tooth disorder 15.26 12.68 20 169514 26213 79548641
Intracranial hypotension 15.14 12.68 10 169524 406 79574448
Cranial nerve disorder 15.10 12.68 15 169519 1095 79573759
Uterine adhesions 15.10 12.68 5 169529 38 79574816
Diaphragmatic paralysis 15.08 12.68 15 169519 1097 79573757
Alpha 1 foetoprotein increased 15.03 12.68 13 169521 795 79574059
Drug ineffective for unapproved indication 15.02 12.68 57 169477 51181 79523673
Balance disorder 14.99 12.68 136 169398 98721 79476133
Duodenal obstruction 14.94 12.68 10 169524 415 79574439
Malaise 14.86 12.68 871 168663 488998 79085856
Arterial thrombosis 14.83 12.68 23 169511 2651 79572203
Chest pain 14.83 12.68 472 169062 281832 79293022
Upper limb fracture 14.80 12.68 10 169524 17957 79556897
Facet joint syndrome 14.79 12.68 3 169531 11299 79563555
Thrombocytopenic purpura 14.78 12.68 22 169512 2447 79572407
Panniculitis 14.77 12.68 4 169530 12367 79562487
Gallbladder rupture 14.73 12.68 14 169520 968 79573886
Intravascular haemolysis 14.73 12.68 13 169521 817 79574037
Hepatic pain 14.72 12.68 29 169505 4043 79570811
Cystic lung disease 14.64 12.68 9 169525 322 79574532
Poor quality sleep 14.63 12.68 16 169518 22706 79552148
Nail pigmentation 14.62 12.68 9 169525 323 79574531
Pigmentation disorder 14.58 12.68 35 169499 5583 79569271
Acute respiratory failure 14.54 12.68 71 169463 59470 79515384
Thirst 14.50 12.68 11 169523 18608 79556246
Injection site haemorrhage 14.49 12.68 23 169511 27847 79547007
Chondronecrosis 14.46 12.68 5 169529 44 79574810
Retinal fibrosis 14.42 12.68 4 169530 15 79574839
Hepatic cirrhosis 14.40 12.68 125 169409 34781 79540073
Haptoglobin decreased 14.39 12.68 16 169518 1331 79573523
Oesophageal carcinoma 14.38 12.68 3 169531 11081 79563773
Sputum discoloured 14.35 12.68 15 169519 21728 79553126
Lymphadenopathy mediastinal 14.34 12.68 30 169504 4366 79570488
Dialysis 14.26 12.68 11 169523 18451 79556403
Bacteroides infection 14.25 12.68 9 169525 338 79574516
Radiation pneumonitis 14.20 12.68 28 169506 3905 79570949
Clostridial infection 14.19 12.68 35 169499 5679 79569175
Tongue disorder 14.11 12.68 6 169528 13969 79560885
Mean platelet volume decreased 14.10 12.68 23 169511 2767 79572087
Macular cyst 14.08 12.68 5 169529 48 79574806
Necrotising colitis 14.05 12.68 14 169520 1026 79573828
Therapy non-responder 13.99 12.68 127 169407 92178 79482676
Hypotony of eye 13.99 12.68 8 169526 250 79574604
Enterobacter test positive 13.98 12.68 10 169524 463 79574391
Diabetic retinal oedema 13.97 12.68 9 169525 350 79574504
Sinus bradycardia 13.93 12.68 20 169514 25227 79549627
Choroidal haemorrhage 13.92 12.68 7 169527 168 79574686
Musculoskeletal discomfort 13.87 12.68 13 169521 19822 79555032
Hepatic rupture 13.70 12.68 6 169528 104 79574750
Pharyngitis streptococcal 13.70 12.68 3 169531 10711 79564143
Gastrointestinal stoma complication 13.69 12.68 22 169512 2615 79572239
Blood pressure systolic abnormal 13.68 12.68 10 169524 17237 79557617
Focal segmental glomerulosclerosis 13.67 12.68 25 169509 3296 79571558
Peritumoural oedema 13.50 12.68 4 169530 20 79574834
Mesenteric vein thrombosis 13.49 12.68 18 169516 1809 79573045
Rash erythematous 13.47 12.68 70 169464 57699 79517155
White blood cell count increased 13.46 12.68 98 169436 74535 79500319
Head discomfort 13.45 12.68 7 169527 14495 79560359
Product storage error 13.41 12.68 9 169525 16217 79558637
Superior vena cava stenosis 13.39 12.68 3 169531 3 79574851
Intestinal varices haemorrhage 13.39 12.68 3 169531 3 79574851
Pelvic sepsis 13.39 12.68 3 169531 3 79574851
Portal vein embolism 13.39 12.68 3 169531 3 79574851
K-ras gene mutation 13.39 12.68 5 169529 56 79574798
Duodenal stenosis 13.32 12.68 12 169522 775 79574079
Pachymeningitis 13.22 12.68 8 169526 278 79574576
Lactobacillus infection 13.21 12.68 9 169525 385 79574469
Pathogen resistance 13.19 12.68 7 169527 14335 79560519
Alpha 1 foetoprotein decreased 13.18 12.68 4 169530 22 79574832
Liver function test increased 13.17 12.68 42 169492 39731 79535123
Dementia 13.16 12.68 20 169514 24639 79550215
Retinal cyst 13.15 12.68 6 169528 115 79574739
Rectal tenesmus 13.14 12.68 17 169517 1658 79573196
Pneumonia chlamydial 13.11 12.68 6 169528 116 79574738
IIIrd nerve paresis 13.10 12.68 7 169527 191 79574663
Prostatic specific antigen increased 13.09 12.68 3 169531 10383 79564471
Tumour pain 13.07 12.68 20 169514 2279 79572575
Tracheal haemorrhage 13.03 12.68 11 169523 651 79574203
Aortitis 12.94 12.68 16 169518 1491 79573363
Rash pustular 12.94 12.68 53 169481 11258 79563596
Ear pain 12.89 12.68 32 169502 32837 79542017
Secretion discharge 12.86 12.68 8 169526 15014 79559840
Tumour embolism 12.81 12.68 7 169527 200 79574654
Adenocarcinoma of colon 12.78 12.68 33 169501 5508 79569346
Renal cancer 12.75 12.68 5 169529 12221 79562633
Staphylococcal bacteraemia 12.74 12.68 5 169529 12213 79562641
Atrioventricular block complete 12.70 12.68 10 169524 16600 79558254

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FG01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors
ATC S01LA08 SENSORY ORGANS
OPHTHALMOLOGICALS
OCULAR VASCULAR DISORDER AGENTS
Antineovascularisation agents
MeSH PA D020533 Angiogenesis Inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances
FDA MoA N0000178291 Vascular Endothelial Growth Factor-directed Antibody Interactions
FDA MoA N0000193542 Vascular Endothelial Growth Factor Inhibitors
FDA EPC N0000193543 Vascular Endothelial Growth Factor Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Secondary malignant neoplasm of colon indication 94260004
Liver cell carcinoma indication 109841003 DOID:684
Malignant neoplasm of breast indication 254837009 DOID:1612
Malignant epithelial tumor of ovary indication 254849005
Carcinoma of cervix indication 285432005 DOID:2893
Malignant tumor of fallopian tube indication 363444001 DOID:1964
Malignant tumor of peritoneum indication 363492001
Glioblastoma multiforme indication 393563007
Nonsquamous nonsmall cell neoplasm of lung indication 440173001
Metastatic renal cell carcinoma indication 702392008
Non-small cell lung cancer with mutation in epidermal growth factor receptor indication 703228009
Malignant neoplasm of colon and/or rectum indication 781382000
Metastatic carcinoma to colon indication 1237484006
Age-related macular degeneration off-label use 267718000 DOID:10871
Pregnancy, function contraindication 289908002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vascular endothelial growth factor A Secreted ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D06409 KEGG_DRUG
4021437 VUID
N0000148845 NUI
4021437 VANDF
4038596 VANDF
CHEMBL1201583 ChEMBL_ID
6771 IUPHAR_LIGAND_ID
DB00112 DRUGBANK_ID
2046138 RXNORM
18086 MMSL
267594 MMSL
33386 MMSL
49612 MMSL
d05214 MMSL
d08039 MMSL
008586 NDDF
017340 NDDF
409405006 SNOMEDCT_US
409406007 SNOMEDCT_US
C0796392 UMLSCUI
D000068258 MESH_DESCRIPTOR_UI
8017 INN_ID
2S9ZZM9Q9V UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0315 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0315 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0342 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
Zirabev HUMAN PRESCRIPTION DRUG LABEL 1 0069-0342 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-060 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 28 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-060 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 28 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-061 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 28 sections
Avastin HUMAN PRESCRIPTION DRUG LABEL 1 50242-061 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 28 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-206 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-206 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-206 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 30 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-207 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-207 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
MVASI HUMAN PRESCRIPTION DRUG LABEL 1 55513-207 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 30 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 70121-1754 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 24 sections
ALYMSYS HUMAN PRESCRIPTION DRUG LABEL 1 70121-1755 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 24 sections
Vegzelma HUMAN PRESCRIPTION DRUG LABEL 1 72606-011 INJECTION, SOLUTION 100 mg INTRAVENOUS BLA 29 sections
Vegzelma HUMAN PRESCRIPTION DRUG LABEL 1 72606-012 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 29 sections