Stem definition | Drug id | CAS RN |
---|---|---|
human origin | 4955 | 339177-26-3 |
Molecule | Description |
---|---|
Synonyms:
|
Recombinant human monoclonal antibody that binds to and inhibits the function of the EPIDERMAL GROWTH FACTOR RECEPTOR. It is used in the treatment of EGFR-expressing metastatic colorectal cancer that expresses wild-type ras gene (see GENES, RAS).
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 3, 2007 | EMA | Amgen Europe B.V. | |
Sept. 27, 2006 | FDA | AMGEN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dermatitis acneiform | 972.71 | 27.11 | 209 | 9060 | 3848 | 50592007 |
Skin toxicity | 490.83 | 27.11 | 119 | 9150 | 3794 | 50592061 |
Paronychia | 482.59 | 27.11 | 121 | 9148 | 4443 | 50591412 |
Hypomagnesaemia | 365.36 | 27.11 | 143 | 9126 | 23013 | 50572842 |
Dry skin | 262.50 | 27.11 | 137 | 9132 | 43054 | 50552801 |
Stomatitis | 213.02 | 27.11 | 164 | 9105 | 101180 | 50494675 |
Rash | 206.39 | 27.11 | 320 | 8949 | 437151 | 50158704 |
Neutropenia | 198.80 | 27.11 | 185 | 9084 | 147780 | 50448075 |
Disease progression | 190.27 | 27.11 | 150 | 9119 | 95716 | 50500139 |
Skin fissures | 174.38 | 27.11 | 64 | 9205 | 8604 | 50587251 |
Neuropathy peripheral | 161.68 | 27.11 | 137 | 9132 | 96620 | 50499235 |
Diarrhoea | 157.83 | 27.11 | 337 | 8932 | 588139 | 50007716 |
Rash pustular | 119.87 | 27.11 | 45 | 9224 | 6436 | 50589419 |
Skin disorder | 111.92 | 27.11 | 64 | 9205 | 23966 | 50571889 |
Metastases to liver | 105.74 | 27.11 | 58 | 9211 | 20046 | 50575809 |
Neurotoxicity | 101.70 | 27.11 | 51 | 9218 | 14689 | 50581166 |
Palmar-plantar erythrodysaesthesia syndrome | 100.27 | 27.11 | 56 | 9213 | 20042 | 50575813 |
Skin reaction | 91.68 | 27.11 | 44 | 9225 | 11524 | 50584331 |
Neutrophil count decreased | 84.69 | 27.11 | 69 | 9200 | 45957 | 50549898 |
Mucosal inflammation | 84.19 | 27.11 | 65 | 9204 | 40077 | 50555778 |
Peripheral sensory neuropathy | 84.12 | 27.11 | 35 | 9234 | 6556 | 50589299 |
Thrombocytopenia | 79.48 | 27.11 | 107 | 9162 | 127566 | 50468289 |
Drug ineffective | 79.33 | 27.11 | 26 | 9243 | 819307 | 49776548 |
Xerosis | 67.82 | 27.11 | 17 | 9252 | 620 | 50595235 |
Therapy partial responder | 67.64 | 27.11 | 30 | 9239 | 6561 | 50589294 |
Hypertrichosis | 64.62 | 27.11 | 18 | 9251 | 991 | 50594864 |
Polyneuropathy | 61.03 | 27.11 | 34 | 9235 | 12097 | 50583758 |
Malignant neoplasm progression | 59.94 | 27.11 | 68 | 9201 | 68056 | 50527799 |
Hypokalaemia | 58.18 | 27.11 | 76 | 9193 | 87916 | 50507939 |
Acne | 57.70 | 27.11 | 39 | 9230 | 19556 | 50576299 |
Hypocalcaemia | 55.28 | 27.11 | 43 | 9226 | 26773 | 50569082 |
Trichomegaly | 53.78 | 27.11 | 9 | 9260 | 37 | 50595818 |
Decreased appetite | 53.16 | 27.11 | 115 | 9154 | 200808 | 50395047 |
Blood magnesium decreased | 52.67 | 27.11 | 30 | 9239 | 11130 | 50584725 |
Febrile neutropenia | 50.56 | 27.11 | 75 | 9194 | 97592 | 50498263 |
Dehydration | 48.26 | 27.11 | 94 | 9175 | 152355 | 50443500 |
Colorectal cancer metastatic | 46.25 | 27.11 | 12 | 9257 | 503 | 50595352 |
Anaemia | 45.89 | 27.11 | 125 | 9144 | 252331 | 50343524 |
Erythema | 44.79 | 27.11 | 89 | 9180 | 146325 | 50449530 |
Ileal perforation | 44.51 | 27.11 | 11 | 9258 | 378 | 50595477 |
Leukopenia | 42.57 | 27.11 | 57 | 9212 | 67471 | 50528384 |
Arthralgia | 42.13 | 27.11 | 14 | 9255 | 438688 | 50157167 |
Carcinoembryonic antigen increased | 41.56 | 27.11 | 14 | 9255 | 1460 | 50594395 |
Growth of eyelashes | 41.08 | 27.11 | 9 | 9260 | 180 | 50595675 |
Death | 38.65 | 27.11 | 139 | 9130 | 325240 | 50270615 |
Conjunctivitis | 37.93 | 27.11 | 28 | 9241 | 16117 | 50579738 |
Fall | 37.21 | 27.11 | 8 | 9261 | 334924 | 50260931 |
Ileus | 35.80 | 27.11 | 25 | 9244 | 13204 | 50582651 |
Dermatitis | 34.12 | 27.11 | 25 | 9244 | 14226 | 50581629 |
Pain of skin | 33.88 | 27.11 | 20 | 9249 | 7927 | 50587928 |
Interstitial lung disease | 33.68 | 27.11 | 45 | 9224 | 53131 | 50542724 |
Xeroderma | 33.67 | 27.11 | 7 | 9262 | 108 | 50595747 |
Headache | 32.69 | 27.11 | 27 | 9242 | 506508 | 50089347 |
Eye irritation | 32.13 | 27.11 | 26 | 9243 | 17114 | 50578741 |
Gastrointestinal toxicity | 31.71 | 27.11 | 16 | 9253 | 4661 | 50591194 |
Metastases to lung | 30.22 | 27.11 | 21 | 9248 | 10999 | 50584856 |
Abdominal discomfort | 29.06 | 27.11 | 4 | 9265 | 231637 | 50364218 |
Large intestine perforation | 27.17 | 27.11 | 17 | 9252 | 7477 | 50588378 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dermatitis acneiform | 1809.22 | 24.14 | 442 | 14481 | 5049 | 29554555 |
Paronychia | 1018.83 | 24.14 | 247 | 14676 | 2706 | 29556898 |
Skin toxicity | 828.57 | 24.14 | 220 | 14703 | 3551 | 29556053 |
Hypomagnesaemia | 607.15 | 24.14 | 253 | 14670 | 17215 | 29542389 |
Rash | 480.68 | 24.14 | 531 | 14392 | 189288 | 29370316 |
Skin reaction | 349.08 | 24.14 | 117 | 14806 | 4300 | 29555304 |
Stomatitis | 319.99 | 24.14 | 211 | 14712 | 36902 | 29522702 |
Rash pustular | 318.88 | 24.14 | 111 | 14812 | 4580 | 29555024 |
Interstitial lung disease | 296.80 | 24.14 | 240 | 14683 | 57478 | 29502126 |
Disease progression | 246.38 | 24.14 | 252 | 14671 | 81664 | 29477940 |
Dry skin | 236.65 | 24.14 | 147 | 14776 | 23160 | 29536444 |
Diarrhoea | 221.81 | 24.14 | 504 | 14419 | 332194 | 29227410 |
Metastases to liver | 213.71 | 24.14 | 109 | 14814 | 11747 | 29547857 |
Neutropenia | 190.70 | 24.14 | 280 | 14643 | 131431 | 29428173 |
Neuropathy peripheral | 189.32 | 24.14 | 205 | 14718 | 70822 | 29488782 |
Acne | 184.49 | 24.14 | 91 | 14832 | 9129 | 29550475 |
Skin disorder | 175.74 | 24.14 | 95 | 14828 | 11523 | 29548081 |
Folliculitis | 150.55 | 24.14 | 61 | 14862 | 3839 | 29555765 |
Mucosal inflammation | 134.49 | 24.14 | 118 | 14805 | 31477 | 29528127 |
Skin fissures | 116.81 | 24.14 | 51 | 14872 | 3868 | 29555736 |
Conjunctivitis | 111.53 | 24.14 | 62 | 14861 | 7936 | 29551668 |
Therapy partial responder | 109.02 | 24.14 | 53 | 14870 | 5146 | 29554458 |
Decreased appetite | 108.21 | 24.14 | 231 | 14692 | 145111 | 29414493 |
Drug ineffective | 94.44 | 24.14 | 33 | 14890 | 363137 | 29196467 |
Metastases to lung | 93.71 | 24.14 | 55 | 14868 | 7800 | 29551804 |
Carcinoembryonic antigen increased | 93.53 | 24.14 | 27 | 14896 | 597 | 29559007 |
Neutrophil count decreased | 89.37 | 24.14 | 110 | 14813 | 43457 | 29516147 |
Neurotoxicity | 86.15 | 24.14 | 66 | 14857 | 14547 | 29545057 |
Xerosis | 86.08 | 24.14 | 24 | 14899 | 466 | 29559138 |
Palmar-plantar erythrodysaesthesia syndrome | 83.38 | 24.14 | 65 | 14858 | 14694 | 29544910 |
Hypocalcaemia | 79.62 | 24.14 | 73 | 14850 | 20592 | 29539012 |
Polyneuropathy | 74.08 | 24.14 | 56 | 14867 | 12096 | 29547508 |
Peripheral sensory neuropathy | 71.93 | 24.14 | 42 | 14881 | 5897 | 29553707 |
Blood magnesium decreased | 67.60 | 24.14 | 39 | 14884 | 5355 | 29554249 |
Drug interaction | 58.38 | 24.14 | 14 | 14909 | 197371 | 29362233 |
Erythema | 58.21 | 24.14 | 122 | 14801 | 75484 | 29484120 |
Thrombocytopenia | 56.87 | 24.14 | 173 | 14750 | 134650 | 29424954 |
Dermatitis | 56.74 | 24.14 | 40 | 14883 | 7758 | 29551846 |
Trichomegaly | 54.62 | 24.14 | 10 | 14913 | 21 | 29559583 |
Headache | 54.15 | 24.14 | 11 | 14912 | 173996 | 29385608 |
Ileus | 51.84 | 24.14 | 49 | 14874 | 14353 | 29545251 |
Colorectal cancer metastatic | 48.85 | 24.14 | 16 | 14907 | 545 | 29559059 |
Growth of eyelashes | 46.93 | 24.14 | 10 | 14913 | 57 | 29559547 |
Dehydration | 46.27 | 24.14 | 145 | 14778 | 114603 | 29445001 |
Arthralgia | 45.18 | 24.14 | 8 | 14915 | 139609 | 29419995 |
Pulmonary embolism | 43.93 | 24.14 | 110 | 14813 | 76424 | 29483180 |
Metastases to lymph nodes | 42.39 | 24.14 | 26 | 14897 | 3991 | 29555613 |
Metastases to pelvis | 41.66 | 24.14 | 12 | 14911 | 263 | 29559341 |
Perioral dermatitis | 40.97 | 24.14 | 10 | 14913 | 112 | 29559492 |
Hepatectomy | 40.28 | 24.14 | 9 | 14914 | 66 | 29559538 |
Intestinal obstruction | 40.01 | 24.14 | 49 | 14874 | 19228 | 29540376 |
Catheter site thrombosis | 39.49 | 24.14 | 8 | 14915 | 34 | 29559570 |
Metastases to peritoneum | 36.45 | 24.14 | 17 | 14906 | 1503 | 29558101 |
Carbohydrate antigen 19-9 increased | 36.42 | 24.14 | 10 | 14913 | 183 | 29559421 |
Somnolence | 36.19 | 24.14 | 3 | 14920 | 93952 | 29465652 |
Febrile neutropenia | 34.00 | 24.14 | 129 | 14794 | 112111 | 29447493 |
Fall | 33.98 | 24.14 | 24 | 14899 | 177154 | 29382450 |
Gastrointestinal toxicity | 33.81 | 24.14 | 18 | 14905 | 2113 | 29557491 |
Toxicity to various agents | 32.68 | 24.14 | 24 | 14899 | 173637 | 29385967 |
Product dose omission issue | 32.32 | 24.14 | 5 | 14918 | 96378 | 29463226 |
Livedo reticularis | 31.34 | 24.14 | 17 | 14906 | 2071 | 29557533 |
Hypertrichosis | 30.77 | 24.14 | 10 | 14913 | 332 | 29559272 |
Nail disorder | 30.62 | 24.14 | 16 | 14907 | 1808 | 29557796 |
Ectropion | 29.58 | 24.14 | 7 | 14916 | 68 | 29559536 |
Acne pustular | 29.13 | 24.14 | 7 | 14916 | 73 | 29559531 |
Skin exfoliation | 28.15 | 24.14 | 45 | 14878 | 22600 | 29537004 |
Epidermal naevus syndrome | 27.82 | 24.14 | 5 | 14918 | 9 | 29559595 |
Dermatitis infected | 27.58 | 24.14 | 7 | 14916 | 93 | 29559511 |
Overdose | 27.08 | 24.14 | 4 | 14919 | 79815 | 29479789 |
Myocardial infarction | 26.89 | 24.14 | 11 | 14912 | 110285 | 29449319 |
Dizziness | 26.65 | 24.14 | 34 | 14889 | 189650 | 29369954 |
Eyelash changes | 26.56 | 24.14 | 5 | 14918 | 13 | 29559591 |
Device related infection | 26.56 | 24.14 | 36 | 14887 | 15600 | 29544004 |
Enterocolitis | 26.54 | 24.14 | 24 | 14899 | 6642 | 29552962 |
Vena cava thrombosis | 26.33 | 24.14 | 12 | 14911 | 1006 | 29558598 |
Cough | 25.86 | 24.14 | 16 | 14907 | 126711 | 29432893 |
Cardiac failure congestive | 25.61 | 24.14 | 4 | 14919 | 76577 | 29483027 |
Drug effective for unapproved indication | 25.10 | 24.14 | 13 | 14910 | 1442 | 29558162 |
Confusional state | 24.93 | 24.14 | 17 | 14906 | 127860 | 29431744 |
Myalgia | 24.45 | 24.14 | 4 | 14919 | 74015 | 29485589 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dermatitis acneiform | 2500.69 | 22.88 | 571 | 19917 | 7872 | 64470372 |
Paronychia | 1268.50 | 22.88 | 314 | 20174 | 6178 | 64472066 |
Skin toxicity | 1079.67 | 22.88 | 277 | 20211 | 6325 | 64471919 |
Hypomagnesaemia | 751.63 | 22.88 | 321 | 20167 | 37055 | 64441189 |
Stomatitis | 467.34 | 22.88 | 338 | 20150 | 109267 | 64368977 |
Rash | 438.14 | 22.88 | 626 | 19862 | 457923 | 64020321 |
Disease progression | 429.73 | 22.88 | 357 | 20131 | 141323 | 64336921 |
Dry skin | 418.27 | 22.88 | 238 | 20250 | 50923 | 64427321 |
Neuropathy peripheral | 393.89 | 22.88 | 314 | 20174 | 117211 | 64361033 |
Rash pustular | 357.57 | 22.88 | 130 | 20358 | 9755 | 64468489 |
Interstitial lung disease | 355.18 | 22.88 | 274 | 20214 | 97458 | 64380786 |
Neutropenia | 327.41 | 22.88 | 391 | 20097 | 239233 | 64239011 |
Metastases to liver | 299.41 | 22.88 | 148 | 20340 | 23793 | 64454451 |
Diarrhoea | 298.58 | 22.88 | 685 | 19803 | 722019 | 63756225 |
Skin reaction | 270.94 | 22.88 | 113 | 20375 | 12239 | 64466005 |
Skin disorder | 251.16 | 22.88 | 138 | 20350 | 27542 | 64450702 |
Skin fissures | 211.71 | 22.88 | 90 | 20398 | 10216 | 64468028 |
Acne | 206.43 | 22.88 | 114 | 20374 | 22967 | 64455277 |
Therapy partial responder | 192.46 | 22.88 | 84 | 20404 | 10164 | 64468080 |
Mucosal inflammation | 185.72 | 22.88 | 156 | 20332 | 62428 | 64415816 |
Palmar-plantar erythrodysaesthesia syndrome | 185.46 | 22.88 | 115 | 20373 | 28704 | 64449540 |
Neutrophil count decreased | 166.96 | 22.88 | 161 | 20327 | 77035 | 64401209 |
Neurotoxicity | 165.39 | 22.88 | 105 | 20383 | 27299 | 64450945 |
Thrombocytopenia | 150.43 | 22.88 | 261 | 20227 | 223540 | 64254704 |
Decreased appetite | 148.95 | 22.88 | 296 | 20192 | 280993 | 64197251 |
Polyneuropathy | 142.39 | 22.88 | 85 | 20403 | 19809 | 64458435 |
Metastases to lung | 127.21 | 22.88 | 72 | 20416 | 15192 | 64463052 |
Peripheral sensory neuropathy | 117.92 | 22.88 | 62 | 20426 | 11316 | 64466928 |
Carcinoembryonic antigen increased | 116.44 | 22.88 | 37 | 20451 | 1836 | 64476408 |
Drug ineffective | 113.97 | 22.88 | 63 | 20425 | 840184 | 63638060 |
Conjunctivitis | 110.53 | 22.88 | 73 | 20415 | 20281 | 64457963 |
Hypocalcaemia | 109.44 | 22.88 | 97 | 20391 | 41656 | 64436588 |
Trichomegaly | 92.21 | 22.88 | 17 | 20471 | 70 | 64478174 |
Hypertrichosis | 89.61 | 22.88 | 27 | 20461 | 1121 | 64477123 |
Headache | 85.22 | 22.88 | 31 | 20457 | 529436 | 63948808 |
Arthralgia | 81.85 | 22.88 | 20 | 20468 | 442240 | 64036004 |
Xerosis | 80.68 | 22.88 | 24 | 20464 | 953 | 64477291 |
Dermatitis | 75.21 | 22.88 | 55 | 20433 | 17974 | 64460270 |
Ileus | 73.79 | 22.88 | 60 | 20428 | 22906 | 64455338 |
Colorectal cancer metastatic | 68.19 | 22.88 | 21 | 20467 | 939 | 64477305 |
Drug interaction | 67.70 | 22.88 | 16 | 20472 | 362067 | 64116177 |
Fall | 64.36 | 22.88 | 26 | 20462 | 416800 | 64061444 |
Leukopenia | 61.32 | 22.88 | 113 | 20375 | 101129 | 64377115 |
Erythema | 61.17 | 22.88 | 163 | 20325 | 186907 | 64291337 |
Febrile neutropenia | 54.89 | 22.88 | 157 | 20331 | 187500 | 64290744 |
Blood magnesium decreased | 50.39 | 22.88 | 39 | 20449 | 13866 | 64464378 |
Metastases to lymph nodes | 49.10 | 22.88 | 32 | 20456 | 8685 | 64469559 |
Ectropion | 48.58 | 22.88 | 13 | 20475 | 349 | 64477895 |
Pain | 48.48 | 22.88 | 63 | 20425 | 553448 | 63924796 |
Malignant neoplasm progression | 48.18 | 22.88 | 109 | 20379 | 112762 | 64365482 |
Carbohydrate antigen 19-9 increased | 47.99 | 22.88 | 13 | 20475 | 366 | 64477878 |
Product dose omission issue | 46.99 | 22.88 | 4 | 20484 | 194743 | 64283501 |
Hypokalaemia | 46.88 | 22.88 | 113 | 20375 | 121790 | 64356454 |
Hepatectomy | 46.56 | 22.88 | 11 | 20477 | 175 | 64478069 |
Peripheral swelling | 46.10 | 22.88 | 6 | 20482 | 209147 | 64269097 |
Folliculitis | 45.70 | 22.88 | 52 | 20436 | 30025 | 64448219 |
Intestinal obstruction | 44.10 | 22.88 | 56 | 20432 | 36230 | 64442014 |
Gastrointestinal toxicity | 44.05 | 22.88 | 25 | 20463 | 5297 | 64472947 |
Growth of eyelashes | 43.99 | 22.88 | 10 | 20478 | 133 | 64478111 |
Toxicity to various agents | 42.58 | 22.88 | 32 | 20456 | 363481 | 64114763 |
Depression | 41.02 | 22.88 | 5 | 20483 | 183286 | 64294958 |
Death | 40.53 | 22.88 | 277 | 20211 | 482428 | 63995816 |
Dermatitis infected | 39.84 | 22.88 | 10 | 20478 | 207 | 64478037 |
Pulmonary embolism | 39.47 | 22.88 | 119 | 20369 | 146237 | 64332007 |
Pain in extremity | 39.06 | 22.88 | 24 | 20464 | 303061 | 64175183 |
Metastases to peritoneum | 38.66 | 22.88 | 20 | 20468 | 3527 | 64474717 |
Somnolence | 38.01 | 22.88 | 9 | 20479 | 203636 | 64274608 |
Nasopharyngitis | 37.94 | 22.88 | 8 | 20480 | 196065 | 64282179 |
Confusional state | 37.55 | 22.88 | 18 | 20470 | 261126 | 64217118 |
Ileal perforation | 36.97 | 22.88 | 13 | 20475 | 883 | 64477361 |
Skin exfoliation | 34.91 | 22.88 | 56 | 20432 | 44829 | 64433415 |
Product use issue | 34.28 | 22.88 | 4 | 20484 | 151711 | 64326533 |
Cough | 33.60 | 22.88 | 28 | 20460 | 302120 | 64176124 |
Dysgeusia | 32.96 | 22.88 | 56 | 20432 | 46991 | 64431253 |
Perioral dermatitis | 32.87 | 22.88 | 9 | 20479 | 264 | 64477980 |
Dizziness | 32.68 | 22.88 | 54 | 20434 | 430109 | 64048135 |
Livedo reticularis | 32.32 | 22.88 | 18 | 20470 | 3679 | 64474565 |
Mucocutaneous rash | 32.11 | 22.88 | 6 | 20482 | 27 | 64478217 |
Hyperammonaemia | 32.07 | 22.88 | 26 | 20462 | 9878 | 64468366 |
Thrombocytopenic purpura | 31.95 | 22.88 | 15 | 20473 | 2147 | 64476097 |
Haematotoxicity | 31.87 | 22.88 | 29 | 20459 | 12867 | 64465377 |
Metastases to pelvis | 30.87 | 22.88 | 10 | 20478 | 528 | 64477716 |
Cardiac failure congestive | 30.64 | 22.88 | 3 | 20485 | 130577 | 64347667 |
Epidermal naevus syndrome | 30.13 | 22.88 | 5 | 20483 | 9 | 64478235 |
Overdose | 29.88 | 22.88 | 7 | 20481 | 159559 | 64318685 |
Drug effective for unapproved indication | 29.57 | 22.88 | 17 | 20471 | 3691 | 64474553 |
Gene mutation | 29.40 | 22.88 | 14 | 20474 | 2068 | 64476176 |
Abdominal discomfort | 28.70 | 22.88 | 11 | 20477 | 182311 | 64295933 |
Pain of skin | 28.69 | 22.88 | 24 | 20464 | 9523 | 64468721 |
Musculoskeletal stiffness | 28.46 | 22.88 | 3 | 20485 | 123203 | 64355041 |
Swelling | 28.14 | 22.88 | 8 | 20480 | 160210 | 64318034 |
Device related infection | 27.73 | 22.88 | 41 | 20447 | 30585 | 64447659 |
Drug hypersensitivity | 27.73 | 22.88 | 21 | 20467 | 237794 | 64240450 |
Enterocolitis | 27.71 | 22.88 | 26 | 20462 | 11992 | 64466252 |
Metastasis | 27.50 | 22.88 | 19 | 20469 | 5676 | 64472568 |
Blepharitis | 26.69 | 22.88 | 14 | 20474 | 2541 | 64475703 |
Nail disorder | 26.58 | 22.88 | 22 | 20466 | 8602 | 64469642 |
Neoplasm progression | 26.40 | 22.88 | 47 | 20441 | 40917 | 64437327 |
Colorectal cancer | 26.31 | 22.88 | 15 | 20473 | 3206 | 64475038 |
Catheter site thrombosis | 26.09 | 22.88 | 7 | 20481 | 190 | 64478054 |
Xeroderma | 25.64 | 22.88 | 7 | 20481 | 203 | 64478041 |
Dehydration | 25.53 | 22.88 | 136 | 20352 | 216627 | 64261617 |
Ascites | 25.47 | 22.88 | 59 | 20429 | 61942 | 64416302 |
Drug intolerance | 25.46 | 22.88 | 14 | 20474 | 187978 | 64290266 |
Eye irritation | 25.08 | 22.88 | 28 | 20460 | 15828 | 64462416 |
Insomnia | 25.01 | 22.88 | 16 | 20472 | 197820 | 64280424 |
Therapeutic product effect decreased | 23.81 | 22.88 | 4 | 20484 | 115347 | 64362897 |
Venoocclusive liver disease | 23.73 | 22.88 | 22 | 20466 | 9993 | 64468251 |
Pigmentation disorder | 23.72 | 22.88 | 16 | 20472 | 4596 | 64473648 |
Bone marrow failure | 23.51 | 22.88 | 49 | 20439 | 47903 | 64430341 |
Anxiety | 23.49 | 22.88 | 18 | 20470 | 202631 | 64275613 |
Asthenia | 23.48 | 22.88 | 223 | 20265 | 427821 | 64050423 |
Weight increased | 23.42 | 22.88 | 20 | 20468 | 213328 | 64264916 |
Anaemia | 23.17 | 22.88 | 202 | 20286 | 378478 | 64099766 |
Blood pressure increased | 23.15 | 22.88 | 13 | 20475 | 172539 | 64305705 |
None
Source | Code | Description |
---|---|---|
ATC | L01FE02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES EGFR (Epidermal Growth Factor Receptor) inhibitors |
FDA CS | M0001357 | Antibodies, Monoclonal |
FDA MoA | N0000020010 | HER1 Antagonists |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000074322 | Antineoplastic Agents, Immunological |
FDA EPC | N0000175664 | Epidermal Growth Factor Receptor Antagonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Secondary malignant neoplasm of colon | indication | 94260004 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor | Kinase | AGONIST | Kd | 10.30 | IUPHAR | DRUG LABEL |
ID | Source |
---|---|
D05350 | KEGG_DRUG |
4025701 | VUID |
N0000179714 | NUI |
4025701 | VANDF |
CHEMBL1201827 | ChEMBL_ID |
6883 | IUPHAR_LIGAND_ID |
8499 | INN_ID |
DB01269 | DRUGBANK_ID |
6A901E312A | UNII |
263034 | RXNORM |
22205 | MMSL |
88497 | MMSL |
d05879 | MMSL |
423259008 | SNOMEDCT_US |
424401006 | SNOMEDCT_US |
D000077544 | MESH_DESCRIPTOR_UI |
C0879427 | UMLSCUI |
011743 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Vectibix | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-954 | SOLUTION | 100 mg | INTRAVENOUS | BLA | 28 sections |
Vectibix | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-956 | SOLUTION | 400 mg | INTRAVENOUS | BLA | 28 sections |