Stem definition | Drug id | CAS RN |
---|---|---|
chimeric origin | 4954 | 205923-56-4 |
Molecule | Description |
---|---|
Synonyms:
|
A chimeric monoclonal antibody that functions as an ANTINEOPLASTIC AGENT through its binding to the EPIDERMAL GROWTH FACTOR RECEPTOR, where it prevents the binding and signaling action of cell growth and survival factors.
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
July 16, 2008 | PMDA | Merck | |
Feb. 12, 2004 | FDA | IMCLONE | |
June 29, 2004 | EMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dermatitis acneiform | 386.71 | 22.00 | 104 | 10697 | 3966 | 46671295 |
Diarrhoea | 176.13 | 22.00 | 393 | 10408 | 559209 | 46116052 |
Mucosal inflammation | 174.64 | 22.00 | 110 | 10691 | 38866 | 46636395 |
Dehydration | 152.76 | 22.00 | 186 | 10615 | 159354 | 46515907 |
Neutropenia | 152.01 | 22.00 | 176 | 10625 | 143028 | 46532233 |
Malignant neoplasm progression | 142.82 | 22.00 | 119 | 10682 | 64807 | 46610454 |
Hypomagnesaemia | 136.82 | 22.00 | 77 | 10724 | 22133 | 46653128 |
Rash | 135.52 | 22.00 | 271 | 10530 | 356241 | 46319020 |
Infusion related reaction | 116.79 | 22.00 | 130 | 10671 | 101078 | 46574183 |
Stomatitis | 93.31 | 22.00 | 96 | 10705 | 68201 | 46607060 |
Paronychia | 85.14 | 22.00 | 34 | 10767 | 4532 | 46670729 |
Drug ineffective | 84.90 | 22.00 | 26 | 10775 | 677812 | 45997449 |
Vomiting | 83.17 | 22.00 | 261 | 10540 | 452533 | 46222728 |
Disease progression | 76.90 | 22.00 | 100 | 10701 | 91200 | 46584061 |
Radiation skin injury | 72.49 | 22.00 | 20 | 10781 | 837 | 46674424 |
Hypokalaemia | 64.33 | 22.00 | 90 | 10711 | 87934 | 46587327 |
Skin toxicity | 63.95 | 22.00 | 26 | 10775 | 3628 | 46671633 |
Pulmonary embolism | 60.77 | 22.00 | 98 | 10703 | 108487 | 46566774 |
Skin fissures | 56.61 | 22.00 | 30 | 10771 | 7650 | 46667611 |
Nausea | 56.33 | 22.00 | 309 | 10492 | 687145 | 45988116 |
Dermatitis | 51.12 | 22.00 | 35 | 10766 | 14173 | 46661088 |
Pyrexia | 48.03 | 22.00 | 183 | 10618 | 348619 | 46326642 |
Arthralgia | 47.28 | 22.00 | 13 | 10788 | 364590 | 46310671 |
Metastases to lung | 42.44 | 22.00 | 28 | 10773 | 10668 | 46664593 |
Febrile neutropenia | 41.87 | 22.00 | 77 | 10724 | 94550 | 46580711 |
Palmar-plantar erythrodysaesthesia syndrome | 37.82 | 22.00 | 34 | 10767 | 20417 | 46654844 |
Colorectal cancer metastatic | 35.26 | 22.00 | 11 | 10790 | 709 | 46674552 |
Deep vein thrombosis | 32.90 | 22.00 | 63 | 10738 | 79710 | 46595551 |
Trichomegaly | 32.71 | 22.00 | 6 | 10795 | 35 | 46675226 |
Hypertrichosis | 32.38 | 22.00 | 11 | 10790 | 929 | 46674332 |
Chills | 31.51 | 22.00 | 69 | 10732 | 95963 | 46579298 |
Haematotoxicity | 29.59 | 22.00 | 19 | 10782 | 6914 | 46668347 |
Renal tubular disorder | 28.22 | 22.00 | 13 | 10788 | 2452 | 46672809 |
Thrombocytopenia | 27.81 | 22.00 | 78 | 10723 | 126503 | 46548758 |
Multiple-drug resistance | 27.73 | 22.00 | 13 | 10788 | 2552 | 46672709 |
Stress cardiomyopathy | 27.58 | 22.00 | 19 | 10782 | 7765 | 46667496 |
Nail disorder | 27.34 | 22.00 | 19 | 10782 | 7877 | 46667384 |
Rash pustular | 27.15 | 22.00 | 18 | 10783 | 6911 | 46668350 |
Anastomotic leak | 27.09 | 22.00 | 8 | 10793 | 428 | 46674833 |
Dyspnoea | 26.75 | 22.00 | 207 | 10594 | 515341 | 46159920 |
Drug interaction | 26.73 | 22.00 | 7 | 10794 | 203087 | 46472174 |
Skin reaction | 25.97 | 22.00 | 21 | 10780 | 10925 | 46664336 |
Colon cancer metastatic | 25.96 | 22.00 | 10 | 10791 | 1210 | 46674051 |
Drug hypersensitivity | 25.93 | 22.00 | 12 | 10789 | 243813 | 46431448 |
Ileus | 25.25 | 22.00 | 23 | 10778 | 14041 | 46661220 |
Hypocalcaemia | 25.13 | 22.00 | 31 | 10770 | 26754 | 46648507 |
Weight increased | 25.10 | 22.00 | 4 | 10797 | 164469 | 46510792 |
Anaemia | 24.90 | 22.00 | 121 | 10680 | 255658 | 46419603 |
Dysphagia | 24.73 | 22.00 | 55 | 10746 | 77257 | 46598004 |
Dry skin | 24.25 | 22.00 | 38 | 10763 | 40978 | 46634283 |
Neutrophil count decreased | 23.98 | 22.00 | 39 | 10762 | 43387 | 46631874 |
Abdominal pain | 23.97 | 22.00 | 111 | 10690 | 229920 | 46445341 |
Interstitial lung disease | 23.97 | 22.00 | 44 | 10757 | 53905 | 46621356 |
Anaphylactic reaction | 23.19 | 22.00 | 43 | 10758 | 53069 | 46622192 |
Bone marrow failure | 22.63 | 22.00 | 31 | 10770 | 29638 | 46645623 |
Leukopenia | 22.29 | 22.00 | 49 | 10752 | 68294 | 46606967 |
Steatohepatitis | 22.18 | 22.00 | 7 | 10794 | 469 | 46674792 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dermatitis acneiform | 805.11 | 18.59 | 257 | 21929 | 5432 | 29924860 |
Infusion related reaction | 466.56 | 18.59 | 319 | 21867 | 40245 | 29890047 |
Mucosal inflammation | 433.85 | 18.59 | 274 | 21912 | 30220 | 29900072 |
Anaphylactic reaction | 283.98 | 18.59 | 204 | 21982 | 27778 | 29902514 |
Hypomagnesaemia | 273.70 | 18.59 | 164 | 22022 | 16434 | 29913858 |
Radiation skin injury | 250.57 | 18.59 | 65 | 22121 | 625 | 29929667 |
Dehydration | 248.70 | 18.59 | 376 | 21810 | 123163 | 29807129 |
Rash | 245.22 | 18.59 | 477 | 21709 | 191412 | 29738880 |
Skin toxicity | 231.30 | 18.59 | 88 | 22098 | 3161 | 29927131 |
Paronychia | 194.53 | 18.59 | 76 | 22110 | 2935 | 29927357 |
Stomatitis | 193.15 | 18.59 | 184 | 22002 | 37095 | 29893197 |
Malignant neoplasm progression | 152.22 | 18.59 | 225 | 21961 | 72062 | 29858230 |
Drug ineffective | 132.30 | 18.59 | 44 | 22142 | 340343 | 29589949 |
Dysphagia | 115.73 | 18.59 | 174 | 22012 | 56524 | 29873768 |
Neutropenia | 112.63 | 18.59 | 275 | 21911 | 128265 | 29802027 |
Acne | 107.71 | 18.59 | 74 | 22112 | 9362 | 29920930 |
Chills | 105.78 | 18.59 | 191 | 21995 | 72147 | 29858145 |
Hypotension | 103.78 | 18.59 | 355 | 21831 | 200210 | 29730082 |
Hypersensitivity | 97.93 | 18.59 | 157 | 22029 | 53871 | 29876421 |
Pharyngeal inflammation | 94.98 | 18.59 | 26 | 22160 | 312 | 29929980 |
Diarrhoea | 90.10 | 18.59 | 485 | 21701 | 333618 | 29596674 |
Drug interaction | 80.54 | 18.59 | 24 | 22162 | 199544 | 29730748 |
Flushing | 77.17 | 18.59 | 102 | 22084 | 29390 | 29900902 |
Skin fissures | 75.50 | 18.59 | 41 | 22145 | 3398 | 29926894 |
Dermatitis | 70.46 | 18.59 | 54 | 22132 | 8088 | 29922204 |
Vomiting | 69.46 | 18.59 | 334 | 21852 | 219484 | 29710808 |
Radiation mucositis | 63.05 | 18.59 | 15 | 22171 | 97 | 29930195 |
Erythema | 61.72 | 18.59 | 160 | 22026 | 77291 | 29853001 |
Conjunctivitis | 60.48 | 18.59 | 49 | 22137 | 7951 | 29922341 |
Nausea | 59.91 | 18.59 | 400 | 21786 | 296557 | 29633735 |
Rash pustular | 56.67 | 18.59 | 39 | 22147 | 4944 | 29925348 |
Arthralgia | 55.33 | 18.59 | 16 | 22170 | 135775 | 29794517 |
Oxygen saturation decreased | 53.87 | 18.59 | 107 | 22079 | 43333 | 29886959 |
Hypocalcaemia | 52.95 | 18.59 | 72 | 22114 | 21304 | 29908988 |
Skin reaction | 52.84 | 18.59 | 36 | 22150 | 4489 | 29925803 |
Palmar-plantar erythrodysaesthesia syndrome | 52.78 | 18.59 | 60 | 22126 | 14810 | 29915482 |
Dyspnoea | 52.37 | 18.59 | 423 | 21763 | 332872 | 29597420 |
Toxicity to various agents | 51.53 | 18.59 | 34 | 22152 | 177149 | 29753143 |
Pulmonary embolism | 50.92 | 18.59 | 150 | 22036 | 77985 | 29852307 |
Folliculitis | 49.88 | 18.59 | 32 | 22154 | 3608 | 29926684 |
Fall | 47.58 | 18.59 | 39 | 22147 | 181833 | 29748459 |
Pain in extremity | 46.74 | 18.59 | 12 | 22174 | 110209 | 29820083 |
Pulse absent | 46.70 | 18.59 | 36 | 22150 | 5437 | 29924855 |
Pyrexia | 46.33 | 18.59 | 374 | 21812 | 294115 | 29636177 |
Decreased appetite | 45.95 | 18.59 | 226 | 21960 | 149684 | 29780608 |
Anaphylactic shock | 45.54 | 18.59 | 54 | 22132 | 13939 | 29916353 |
Pruritus | 45.00 | 18.59 | 190 | 21996 | 118014 | 29812278 |
Device related infection | 44.72 | 18.59 | 59 | 22127 | 16956 | 29913336 |
Febrile neutropenia | 43.36 | 18.59 | 175 | 22011 | 106518 | 29823774 |
Dry skin | 43.05 | 18.59 | 67 | 22119 | 22387 | 29907905 |
Product dose omission issue | 42.85 | 18.59 | 8 | 22178 | 91623 | 29838669 |
Proteus infection | 42.03 | 18.59 | 17 | 22169 | 719 | 29929573 |
Insomnia | 41.87 | 18.59 | 9 | 22177 | 93327 | 29836965 |
Disease progression | 41.64 | 18.59 | 142 | 22044 | 79732 | 29850560 |
Leukopenia | 40.64 | 18.59 | 112 | 22074 | 56047 | 29874245 |
Alopecia | 37.62 | 18.59 | 58 | 22128 | 19217 | 29911075 |
Gastrointestinal toxicity | 36.09 | 18.59 | 21 | 22165 | 1987 | 29928305 |
Blood pressure immeasurable | 35.34 | 18.59 | 16 | 22170 | 895 | 29929397 |
Pneumatosis intestinalis | 35.26 | 18.59 | 23 | 22163 | 2667 | 29927625 |
Blood magnesium decreased | 34.07 | 18.59 | 30 | 22156 | 5453 | 29924839 |
Urticaria | 33.81 | 18.59 | 103 | 22083 | 54503 | 29875789 |
Ileus | 33.49 | 18.59 | 49 | 22137 | 15506 | 29914786 |
Clostridial infection | 33.48 | 18.59 | 25 | 22161 | 3600 | 29926692 |
Nail disorder | 33.17 | 18.59 | 19 | 22167 | 1746 | 29928546 |
Condition aggravated | 33.10 | 18.59 | 32 | 22154 | 137834 | 29792458 |
Neutrophil count decreased | 33.05 | 18.59 | 87 | 22099 | 42367 | 29887925 |
Gait disturbance | 31.96 | 18.59 | 8 | 22178 | 74769 | 29855523 |
Oesophagitis | 31.33 | 18.59 | 40 | 22146 | 11131 | 29919161 |
Cardiac failure congestive | 30.77 | 18.59 | 12 | 22174 | 84395 | 29845897 |
Interstitial lung disease | 30.47 | 18.59 | 106 | 22080 | 60091 | 29870201 |
Myalgia | 29.47 | 18.59 | 10 | 22176 | 76657 | 29853635 |
Rhabdomyolysis | 28.77 | 18.59 | 6 | 22180 | 63574 | 29866718 |
Necrotising oesophagitis | 28.43 | 18.59 | 11 | 22175 | 413 | 29929879 |
Colorectal cancer metastatic | 27.87 | 18.59 | 14 | 22172 | 988 | 29929304 |
Nasopharyngitis | 27.80 | 18.59 | 5 | 22181 | 58844 | 29871448 |
Blood pressure decreased | 27.48 | 18.59 | 87 | 22099 | 46988 | 29883304 |
Cardio-respiratory arrest | 27.36 | 18.59 | 99 | 22087 | 57207 | 29873085 |
Headache | 27.31 | 18.59 | 59 | 22127 | 182247 | 29748045 |
Induration | 26.91 | 18.59 | 13 | 22173 | 843 | 29929449 |
Weight increased | 26.73 | 18.59 | 11 | 22175 | 74902 | 29855390 |
Coronary artery disease | 26.33 | 18.59 | 3 | 22183 | 49709 | 29880583 |
Colon cancer metastatic | 26.07 | 18.59 | 16 | 22170 | 1669 | 29928623 |
Thrombocytopenia | 25.92 | 18.59 | 182 | 22004 | 136862 | 29793430 |
Neuropathy peripheral | 25.78 | 18.59 | 112 | 22074 | 70363 | 29859929 |
Prothrombin level decreased | 25.69 | 18.59 | 14 | 22172 | 1168 | 29929124 |
Pneumonitis | 25.29 | 18.59 | 60 | 22126 | 27394 | 29902898 |
White blood cell count decreased | 25.26 | 18.59 | 126 | 22060 | 83821 | 29846471 |
Peripheral swelling | 25.21 | 18.59 | 7 | 22179 | 61067 | 29869225 |
Monocytopenia | 24.64 | 18.59 | 7 | 22179 | 97 | 29930195 |
Laryngeal oedema | 24.42 | 18.59 | 20 | 22166 | 3294 | 29926998 |
Embolism | 24.39 | 18.59 | 28 | 22158 | 6981 | 29923311 |
Aspiration | 23.82 | 18.59 | 34 | 22152 | 10517 | 29919775 |
Anxiety | 23.80 | 18.59 | 19 | 22167 | 89852 | 29840440 |
Metastases to lung | 23.30 | 18.59 | 29 | 22157 | 7866 | 29922426 |
Neoplasm progression | 23.06 | 18.59 | 45 | 22141 | 17978 | 29912314 |
Depression | 22.86 | 18.59 | 20 | 22166 | 90417 | 29839875 |
Hospitalisation | 22.67 | 18.59 | 3 | 22183 | 44316 | 29885976 |
Anaphylactoid reaction | 22.28 | 18.59 | 16 | 22170 | 2170 | 29928122 |
Influenza | 22.05 | 18.59 | 3 | 22183 | 43395 | 29886897 |
Hypophagia | 22.02 | 18.59 | 50 | 22136 | 22186 | 29908106 |
Hypokalaemia | 21.70 | 18.59 | 84 | 22102 | 50108 | 29880184 |
Squamous cell carcinoma of head and neck | 21.63 | 18.59 | 7 | 22179 | 154 | 29930138 |
Somnolence | 21.47 | 18.59 | 24 | 22162 | 96739 | 29833553 |
Unresponsive to stimuli | 21.43 | 18.59 | 55 | 22131 | 26364 | 29903928 |
Abdominal discomfort | 21.27 | 18.59 | 5 | 22181 | 48786 | 29881506 |
Abdominal compartment syndrome | 20.73 | 18.59 | 11 | 22175 | 870 | 29929422 |
Metastases to liver | 20.59 | 18.59 | 34 | 22152 | 11931 | 29918361 |
Butterfly rash | 20.56 | 18.59 | 6 | 22180 | 92 | 29930200 |
Cerebral ischaemia | 20.29 | 18.59 | 24 | 22162 | 6176 | 29924116 |
Bronchospasm | 20.02 | 18.59 | 31 | 22155 | 10307 | 29919985 |
Neutrophilia | 19.89 | 18.59 | 18 | 22168 | 3389 | 29926903 |
Overdose | 19.73 | 18.59 | 20 | 22166 | 84317 | 29845975 |
Cardiac disorder | 19.70 | 18.59 | 3 | 22183 | 39890 | 29890402 |
Ileal perforation | 19.63 | 18.59 | 10 | 22176 | 727 | 29929565 |
Death | 19.61 | 18.59 | 170 | 22016 | 357113 | 29573179 |
Neurotoxicity | 19.46 | 18.59 | 35 | 22151 | 13147 | 29917145 |
Odynophagia | 19.08 | 18.59 | 20 | 22166 | 4507 | 29925785 |
Diabetes mellitus | 18.83 | 18.59 | 4 | 22182 | 41861 | 29888431 |
Mucosal infection | 18.83 | 18.59 | 7 | 22179 | 235 | 29930057 |
Pelvic sepsis | 18.83 | 18.59 | 4 | 22182 | 14 | 29930278 |
Staphylococcal infection | 18.68 | 18.59 | 57 | 22129 | 30167 | 29900125 |
Source | Code | Description |
---|---|---|
ATC | L01XC06 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Monoclonal antibodies |
FDA MoA | N0000020010 | HER1 Antagonists |
FDA EPC | N0000175664 | Epidermal Growth Factor Receptor Antagonist |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000074322 | Antineoplastic Agents, Immunological |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Squamous cell carcinoma of mouth | indication | 307502000 | |
Malignant tumor of colon | indication | 363406005 | DOID:219 |
Squamous cell carcinoma of larynx | indication | 405822008 | |
Squamous cell carcinoma of pharynx | indication | 408649007 | |
Squamous cell carcinoma of nose | indication | 448930008 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor | Kinase | ANTIBODY BINDING | Kd | 9.41 | IUPHAR | DRUG LABEL |
ID | Source |
---|---|
D03455 | KEGG_DRUG |
4021419 | VUID |
N0000148833 | NUI |
4021419 | VANDF |
C0995188 | UMLSCUI |
CHEMBL1201577 | ChEMBL_ID |
DB00002 | DRUGBANK_ID |
D000068818 | MESH_DESCRIPTOR_UI |
6882 | IUPHAR_LIGAND_ID |
7906 | INN_ID |
PQX0D8J21J | UNII |
318341 | RXNORM |
17947 | MMSL |
48970 | MMSL |
d05101 | MMSL |
008568 | NDDF |
409400001 | SNOMEDCT_US |
409401002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ERBITUX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66733-948 | SOLUTION | 2 mg | INTRAVENOUS | BLA | 29 sections |
ERBITUX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66733-958 | SOLUTION | 2 mg | INTRAVENOUS | BLA | 29 sections |