basiliximab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
chimeric origin 4940 179045-86-4

Description:

MoleculeDescription

Synonyms:

  • basiliximab
  • simulect
  • chRFT5
  • SDZ-CHI-621
Basiliximab functions as an IL-2 receptor antagonist by binding with high affinity to the alpha chain of the high affinity IL-2 receptor complex and inhibiting IL-2 binding. Basiliximab is specifically targeted against IL-2Ralpha, which is selectively expressed on the surface of activated T-lymphocytes. This specific high affinity binding of basiliximab to IL-2Ralpha competitively inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
40 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 9, 1998 EMA
May 12, 1998 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Kidney transplant rejection 806.11 29.90 179 10792 4092 63473959
Cytomegalovirus infection 714.16 29.90 226 10745 20726 63457325
Transplant rejection 646.08 29.90 180 10791 10600 63467451
Complications of transplanted kidney 467.81 29.90 104 10867 2382 63475669
Polyomavirus-associated nephropathy 407.13 29.90 88 10883 1760 63476291
Thrombotic microangiopathy 359.75 29.90 114 10857 10447 63467604
Post transplant lymphoproliferative disorder 233.89 29.90 69 10902 4962 63473089
Multiple organ dysfunction syndrome 208.70 29.90 127 10844 56625 63421426
Delayed graft function 207.07 29.90 46 10925 1047 63477004
Cytomegalovirus viraemia 196.53 29.90 62 10909 5587 63472464
Posterior reversible encephalopathy syndrome 179.46 29.90 78 10893 17267 63460784
Immunosuppressant drug level increased 160.83 29.90 48 10923 3590 63474461
Blood creatinine increased 160.67 29.90 128 10843 87716 63390335
Renal impairment 147.34 29.90 122 10849 88233 63389818
Transplant dysfunction 147.02 29.90 48 10923 4824 63473227
Renal tubular necrosis 141.35 29.90 59 10912 11819 63466232
BK virus infection 135.19 29.90 41 10930 3238 63474813
Aspergillus infection 126.77 29.90 49 10922 8044 63470007
Liver transplant rejection 118.97 29.90 31 10940 1404 63476647
Fatigue 117.09 29.90 10 10961 888018 62590033
Hyperammonaemia 116.37 29.90 41 10930 5191 63472860
Nephropathy toxic 112.50 29.90 47 10924 9432 63468619
Escherichia infection 111.53 29.90 51 10920 12703 63465348
Transplant failure 111.20 29.90 30 10941 1555 63476496
Mucormycosis 110.28 29.90 34 10937 2837 63475214
Parvovirus B19 infection 108.53 29.90 24 10947 534 63477517
Focal segmental glomerulosclerosis 94.66 29.90 26 10945 1442 63476609
Leukopenia 87.76 29.90 86 10885 77204 63400847
Atypical haemolytic uraemic syndrome 86.42 29.90 21 10950 714 63477337
Renal transplant failure 85.66 29.90 21 10950 741 63477310
Anuria 84.71 29.90 42 10929 12509 63465542
Enterococcal infection 83.45 29.90 36 10935 7812 63470239
Mycoplasma infection 83.05 29.90 19 10952 495 63477556
Herpes simplex 81.63 29.90 36 10935 8235 63469816
Haemolytic uraemic syndrome 80.96 29.90 26 10945 2477 63475574
Pain 79.29 29.90 16 10955 740612 62737439
Ureteric stenosis 79.18 29.90 19 10952 612 63477439
Diffuse large B-cell lymphoma 78.70 29.90 33 10938 6679 63471372
Klebsiella infection 77.24 29.90 35 10936 8531 63469520
Pancreatitis haemorrhagic 77.06 29.90 18 10953 515 63477536
Chronic allograft nephropathy 76.48 29.90 19 10952 709 63477342
Cerebral aspergillosis 75.76 29.90 17 10954 405 63477646
Lymphocele 74.30 29.90 19 10952 798 63477253
Complications of transplanted lung 71.71 29.90 15 10956 254 63477797
Microsporidia infection 70.23 29.90 15 10956 282 63477769
Arthralgia 68.28 29.90 9 10962 569701 62908350
Pseudomonas infection 68.27 29.90 35 10936 11178 63466873
Glomerulonephritis 67.72 29.90 21 10950 1785 63476266
Scedosporium infection 65.75 29.90 16 10955 547 63477504
Pathogen resistance 63.63 29.90 28 10943 6370 63471681
Kidney fibrosis 62.73 29.90 20 10951 1861 63476190
Product use in unapproved indication 62.02 29.90 111 10860 178969 63299082
Respiratory failure 61.97 29.90 82 10889 101776 63376275
Infectious pleural effusion 61.86 29.90 19 10952 1564 63476487
Human herpesvirus 6 infection 61.31 29.90 22 10949 2935 63475116
Graft complication 60.93 29.90 13 10958 243 63477808
Oedematous pancreatitis 60.21 29.90 15 10956 566 63477485
Disseminated aspergillosis 59.61 29.90 11 10960 93 63477958
Bacteraemia 59.03 29.90 37 10934 17311 63460740
Distributive shock 55.75 29.90 17 10954 1366 63476685
Fall 55.63 29.90 3 10968 392331 63085720
Bronchopulmonary aspergillosis 55.62 29.90 28 10943 8607 63469444
Passenger lymphocyte syndrome 55.49 29.90 10 10961 73 63477978
Ureaplasma infection 53.66 29.90 14 10957 637 63477414
Intestine transplant rejection 53.20 29.90 9 10962 43 63478008
Strongyloidiasis 53.13 29.90 16 10955 1232 63476819
Urinary tract infection 52.92 29.90 131 10840 264553 63213498
Epstein-Barr viraemia 51.99 29.90 15 10956 995 63477056
Oedematous kidney 51.81 29.90 10 10961 110 63477941
Epstein-Barr virus infection 51.55 29.90 26 10945 8024 63470027
Diabetic macroangiopathy 50.78 29.90 10 10961 123 63477928
Renal graft infection 49.47 29.90 11 10960 251 63477800
Acid base balance abnormal 49.18 29.90 11 10960 258 63477793
Shock 48.92 29.90 37 10934 23426 63454625
Haemolytic anaemia 48.66 29.90 27 10944 10098 63467953
Urine output decreased 48.39 29.90 28 10943 11342 63466709
Disseminated tuberculosis 47.18 29.90 18 10953 2849 63475202
Acute respiratory distress syndrome 46.62 29.90 36 10935 23498 63454553
Headache 46.38 29.90 26 10945 633215 62844836
Pericarditis constrictive 45.90 29.90 11 10960 352 63477699
Rash 45.63 29.90 20 10951 560851 62917200
Graft loss 45.61 29.90 11 10960 362 63477689
Urinary fistula 44.47 29.90 7 10964 19 63478032
Dizziness 44.43 29.90 10 10961 429915 63048136
Mastitis bacterial 44.20 29.90 8 10963 60 63477991
Nausea 43.95 29.90 50 10921 854421 62623630
Tubulointerstitial nephritis 42.85 29.90 32 10939 19871 63458180
Polyomavirus viraemia 42.73 29.90 12 10959 722 63477329
Incision site pain 41.47 29.90 13 10958 1145 63476906
Proteinuria 39.48 29.90 30 10941 19115 63458936
Drug hypersensitivity 39.41 29.90 4 10967 310683 63167368
Hypersensitivity 39.21 29.90 3 10968 292682 63185369
Human herpesvirus 8 infection 38.82 29.90 9 10962 249 63477802
Ureteral necrosis 38.74 29.90 7 10964 52 63477999
Ascites 38.34 29.90 41 10930 40687 63437364
Acute kidney injury 38.26 29.90 116 10855 263299 63214752
Biloma 37.85 29.90 7 10964 60 63477991
Oliguria 37.63 29.90 22 10949 9079 63468972
Genital herpes simplex 37.44 29.90 9 10962 292 63477759
Extremity necrosis 37.24 29.90 13 10958 1600 63476451
Diabetes mellitus 37.15 29.90 47 10924 55763 63422288
Aeromonas infection 36.43 29.90 7 10964 75 63477976
Pruritus 36.16 29.90 9 10962 361444 63116607
Pneumocystis jirovecii pneumonia 35.98 29.90 27 10944 16887 63461164
Viraemia 35.83 29.90 12 10959 1304 63476747
Intracranial infection 35.76 29.90 6 10965 27 63478024
Hepatitis B 35.71 29.90 16 10955 3796 63474255
Disseminated intravascular coagulation 35.26 29.90 28 10943 19023 63459028
Anaemia 35.17 29.90 121 10850 293309 63184742
Mycobacterium abscessus infection 34.80 29.90 10 10961 654 63477397
Complications of transplanted liver 34.78 29.90 9 10962 396 63477655
Drug resistance 34.72 29.90 30 10941 22903 63455148
Infective aneurysm 34.70 29.90 9 10962 400 63477651
Nocardiosis 34.66 29.90 13 10958 1963 63476088
Herpes simplex hepatitis 34.50 29.90 9 10962 409 63477642
JC virus infection 34.19 29.90 13 10958 2038 63476013
Rhodococcus infection 33.60 29.90 7 10964 116 63477935
Shock haemorrhagic 33.40 29.90 21 10950 9874 63468177
Renal cortical necrosis 33.22 29.90 7 10964 123 63477928
Encephalitis Japanese B 33.15 29.90 6 10965 45 63478006
Capillaritis 32.70 29.90 7 10964 133 63477918
Death 32.60 29.90 12 10959 374369 63103682
Cytomegalovirus test positive 32.59 29.90 14 10957 3004 63475047
End stage renal disease 32.58 29.90 18 10953 6675 63471376
Dyspnoea 32.54 29.90 40 10931 661273 62816778
Smooth muscle cell neoplasm 32.46 29.90 10 10961 831 63477220
Red blood cells urine positive 32.12 29.90 14 10957 3112 63474939
Abdominal discomfort 32.06 29.90 8 10963 320877 63157174
Pain in extremity 31.73 29.90 9 10962 331477 63146574
Swelling 31.40 29.90 5 10966 275373 63202678
IgA nephropathy 31.21 29.90 9 10962 596 63477455
Immunosuppressant drug level decreased 31.13 29.90 10 10961 953 63477098
Malacoplakia 30.95 29.90 7 10964 173 63477878
Agranulocytosis 30.43 29.90 29 10942 25105 63452946
Adenovirus infection 30.33 29.90 14 10957 3557 63474494
Liver abscess 30.03 29.90 13 10958 2841 63475210

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Kidney transplant rejection 1017.53 19.93 303 18169 7194 34931265
Transplant rejection 652.70 19.93 234 18238 10077 34928382
Cytomegalovirus infection 581.39 19.93 281 18191 25854 34912605
Complications of transplanted kidney 508.52 19.93 159 18313 4450 34934009
Polyomavirus-associated nephropathy 446.70 19.93 138 18334 3706 34934753
Delayed graft function 267.57 19.93 82 18390 2139 34936320
Renal tubular necrosis 236.58 19.93 130 18342 15550 34922909
Mucormycosis 198.69 19.93 85 18387 5857 34932602
Strongyloidiasis 196.04 19.93 68 18404 2643 34935816
Thrombotic microangiopathy 185.19 19.93 97 18375 10533 34927926
Post transplant lymphoproliferative disorder 181.43 19.93 82 18390 6446 34932013
Focal segmental glomerulosclerosis 178.74 19.93 59 18413 1966 34936493
BK virus infection 165.59 19.93 74 18398 5664 34932795
Blood creatinine increased 165.11 19.93 226 18246 94750 34843709
Multiple organ dysfunction syndrome 162.37 19.93 201 18271 76365 34862094
Chronic allograft nephropathy 153.91 19.93 47 18425 1210 34937249
Immunosuppressant drug level increased 152.40 19.93 71 18401 5984 34932475
Parvovirus B19 infection 144.33 19.93 41 18431 814 34937645
Graft versus host disease 141.36 19.93 81 18391 10488 34927971
Incision site pain 140.25 19.93 48 18424 1790 34936669
Nephropathy toxic 125.77 19.93 80 18392 12508 34925951
Cytomegalovirus viraemia 124.28 19.93 66 18406 7364 34931095
Transplant dysfunction 123.13 19.93 48 18424 2601 34935858
Tubulointerstitial nephritis 122.33 19.93 96 18376 20928 34917531
Lymphocyte count decreased 118.23 19.93 97 18375 22525 34915934
Fatigue 116.14 19.93 27 18445 370626 34567833
Epstein-Barr virus infection 114.32 19.93 63 18409 7565 34930894
Death 109.86 19.93 37 18435 398012 34540447
Pneumocystis jirovecii pneumonia 106.12 19.93 86 18386 19624 34918835
Renal transplant failure 100.72 19.93 33 18439 1073 34937386
Kidney fibrosis 98.73 19.93 39 18433 2189 34936270
Liver transplant rejection 97.09 19.93 38 18434 2081 34936378
Aspergillus infection 93.80 19.93 66 18406 12188 34926271
Renal tubular atrophy 90.95 19.93 31 18441 1141 34937318
Fall 90.34 19.93 4 18468 202881 34735578
Complications of transplanted lung 88.45 19.93 21 18451 197 34938262
Renal impairment 86.12 19.93 168 18304 94345 34844114
Neutrophil count increased 84.34 19.93 71 18401 17075 34921384
Leukopenia 83.62 19.93 132 18340 62724 34875735
Dizziness 81.31 19.93 10 18462 218511 34719948
Cytomegalovirus colitis 80.61 19.93 36 18436 2748 34935711
Enterococcal infection 80.38 19.93 54 18418 9252 34929207
Bronchopulmonary aspergillosis 78.98 19.93 64 18408 14595 34923864
Transplant failure 78.20 19.93 38 18434 3515 34934944
Cytomegalovirus test positive 77.91 19.93 39 18433 3847 34934612
Adenovirus infection 77.62 19.93 43 18429 5214 34933245
Candida infection 76.30 19.93 68 18404 17647 34920812
Pseudomonas infection 75.17 19.93 58 18414 12324 34926135
Red blood cells urine positive 74.37 19.93 30 18442 1779 34936680
Human ehrlichiosis 72.66 19.93 20 18452 352 34938107
Klebsiella infection 72.47 19.93 49 18423 8482 34929977
Product use in unapproved indication 71.93 19.93 178 18294 117321 34821138
Nausea 71.44 19.93 46 18426 339862 34598597
Ventricular remodelling 71.03 19.93 15 18457 77 34938382
Glomerulosclerosis 68.44 19.93 23 18449 810 34937649
Pneumonia cytomegaloviral 68.23 19.93 33 18439 3021 34935438
Asthenia 65.43 19.93 24 18448 245227 34693232
Dyspnoea 64.11 19.93 63 18409 376719 34561740
Graft loss 63.25 19.93 22 18450 861 34937598
Protein urine present 61.80 19.93 37 18435 5191 34933268
Hepatitis E 60.48 19.93 27 18445 2059 34936400
Malacoplakia 59.66 19.93 18 18454 444 34938015
Rash 59.06 19.93 22 18450 222730 34715729
Lymphocele 57.50 19.93 23 18449 1334 34937125
Hydronephrosis 57.49 19.93 46 18426 10300 34928159
Blood urea increased 56.80 19.93 75 18397 30289 34908170
Viraemia 56.01 19.93 22 18450 1216 34937243
Skin necrosis 55.48 19.93 36 18436 5817 34932642
Human herpesvirus 8 infection 53.70 19.93 20 18452 955 34937504
Renal tubular injury 53.54 19.93 20 18452 963 34937496
Pain 52.94 19.93 21 18451 204654 34733805
Cryptococcosis 50.63 19.93 25 18447 2394 34936065
Enterobacter infection 50.52 19.93 25 18447 2405 34936054
Haemophagocytic lymphohistiocytosis 50.38 19.93 47 18425 12926 34925533
Arthralgia 49.98 19.93 14 18458 170027 34768432
JC virus infection 49.75 19.93 24 18448 2184 34936275
Graft versus host disease in skin 49.59 19.93 29 18443 3896 34934563
Pruritus 47.06 19.93 9 18463 141972 34796487
Ureteric stenosis 46.61 19.93 19 18453 1157 34937302
Gastrointestinal stromal tumour 46.33 19.93 18 18454 966 34937493
Urine output decreased 46.11 19.93 40 18432 10009 34928450
Respiratory failure 46.09 19.93 144 18328 108428 34830031
Disseminated intravascular coagulation 45.69 19.93 57 18415 21759 34916700
Septic shock 45.14 19.93 110 18362 71724 34866735
Renal tubular disorder 45.10 19.93 29 18443 4614 34933845
Cytomegalovirus infection reactivation 44.91 19.93 30 18442 5088 34933371
Sphincter of Oddi dysfunction 44.42 19.93 11 18461 125 34938334
Schistosomiasis 43.33 19.93 9 18463 42 34938417
Glomerulonephritis 43.06 19.93 21 18451 1957 34936502
Renal haemorrhage 42.69 19.93 19 18453 1438 34937021
Urinary tract infection 41.84 19.93 118 18354 83963 34854496
Proteinuria 41.12 19.93 50 18422 18592 34919867
Scedosporium infection 41.05 19.93 16 18456 866 34937593
Graft versus host disease in gastrointestinal tract 40.79 19.93 25 18447 3658 34934801
Oliguria 39.76 19.93 34 18438 8346 34930113
Drug resistance 39.45 19.93 58 18414 25869 34912590
Intestine transplant rejection 38.94 19.93 8 18464 35 34938424
Hepatitis C 38.91 19.93 36 18436 9794 34928665
Posterior reversible encephalopathy syndrome 38.53 19.93 36 18436 9918 34928541
Headache 38.30 19.93 30 18442 200605 34737854
Systemic candida 38.00 19.93 24 18448 3702 34934757
Abdominal wall abscess 37.10 19.93 13 18459 520 34937939
Renal adenoma 36.39 19.93 7 18465 20 34938439
Nephrosclerosis 36.30 19.93 15 18457 946 34937513
Renal graft infection 36.13 19.93 11 18461 280 34938179
Enterovirus infection 35.93 19.93 15 18457 971 34937488
Urinary fistula 35.74 19.93 9 18463 110 34938349
Tongue necrosis 35.65 19.93 7 18465 23 34938436
Diabetes mellitus 35.18 19.93 77 18395 46796 34891663
Fungaemia 35.18 19.93 20 18452 2548 34935911
Renal artery stenosis 34.77 19.93 19 18453 2242 34936217
Procedural pain 34.73 19.93 25 18447 4781 34933678
Diffuse alveolar damage 34.35 19.93 19 18453 2295 34936164
Nocardiosis 34.29 19.93 23 18449 3928 34934531
Hepatitis A 34.11 19.93 12 18460 486 34937973
Malaise 33.95 19.93 29 18443 185796 34752663
Febrile neutropenia 33.81 19.93 15 18457 136834 34801625
Cerebrovascular accident 33.75 19.93 3 18469 84808 34853651
Mediastinitis 33.72 19.93 13 18459 683 34937776
Insomnia 33.55 19.93 7 18465 103900 34834559
Cytomegalovirus gastritis 33.44 19.93 10 18462 239 34938220
Wound dehiscence 32.95 19.93 21 18451 3290 34935169
Malignant neoplasm progression 32.76 19.93 4 18468 88042 34850417
Hyperammonaemia 32.61 19.93 27 18445 6340 34932119
Depression 32.49 19.93 6 18466 97092 34841367
IgA nephropathy 32.36 19.93 15 18457 1248 34937211
Adenoviral haemorrhagic cystitis 32.32 19.93 11 18461 403 34938056
Back pain 32.28 19.93 12 18460 121777 34816682
Pulmonary mucormycosis 32.24 19.93 13 18459 770 34937689
Fungal skin infection 32.06 19.93 19 18453 2615 34935844
Syncope 32.03 19.93 5 18467 91446 34847013
Lymphopenia 31.54 19.93 41 18431 16294 34922165
Argentine haemorrhagic fever 31.49 19.93 6 18466 16 34938443
Pancreas transplant rejection 31.38 19.93 9 18463 185 34938274
Gait disturbance 31.36 19.93 4 18468 85136 34853323
Pyelonephritis acute 30.83 19.93 17 18455 2042 34936417
Sepsis 30.77 19.93 171 18301 166390 34772069
Acute graft versus host disease in skin 30.77 19.93 24 18448 5177 34933282
Capillaritis 30.57 19.93 8 18464 115 34938344
Cardiac failure congestive 30.45 19.93 4 18468 83266 34855193
Myocardial infarction 30.34 19.93 13 18459 121072 34817387
Nephropathy 30.11 19.93 25 18447 5892 34932567
Arteritis infective 30.05 19.93 6 18466 22 34938437
Restrictive allograft syndrome 29.84 19.93 6 18466 23 34938436
Acute respiratory distress syndrome 29.71 19.93 51 18421 25918 34912541
Disseminated mucormycosis 29.46 19.93 11 18461 529 34937930
Graft complication 29.23 19.93 10 18462 372 34938087
Haemolytic uraemic syndrome 29.17 19.93 17 18455 2269 34936190
Right ventricular diastolic collapse 29.08 19.93 7 18465 70 34938389
American trypanosomiasis 28.88 19.93 9 18463 248 34938211
Intra-abdominal haemorrhage 28.37 19.93 17 18455 2387 34936072
Pancytopenia 28.08 19.93 112 18360 95045 34843414
Acute graft versus host disease 28.06 19.93 25 18447 6478 34931981
Pain in extremity 28.04 19.93 16 18456 126497 34811962
Renal vein thrombosis 27.91 19.93 8 18464 164 34938295
Corynebacterium infection 27.90 19.93 11 18461 614 34937845
Sinusitis aspergillus 27.54 19.93 7 18465 89 34938370
Hepatitis cholestatic 27.46 19.93 27 18445 7920 34930539
Peripheral swelling 27.23 19.93 4 18468 76537 34861922
Hyperuricaemia 27.18 19.93 27 18445 8016 34930443
Escherichia urinary tract infection 26.90 19.93 19 18453 3527 34934932
Cryptosporidiosis infection 26.88 19.93 10 18462 476 34937983
Hyperhidrosis 26.82 19.93 4 18468 75688 34862771
Chest pain 26.74 19.93 17 18455 126745 34811714
Herpes simplex hepatitis 26.72 19.93 7 18465 101 34938358
Transitional cell carcinoma metastatic 26.58 19.93 6 18466 44 34938415
Anuria 26.47 19.93 30 18442 10355 34928104
Hyperglycaemia 26.44 19.93 62 18410 39418 34899041
Distributive shock 26.36 19.93 13 18459 1241 34937218
Renal arteriosclerosis 26.26 19.93 8 18464 204 34938255
Fungal infection 26.21 19.93 37 18435 15898 34922561
Somnolence 26.17 19.93 13 18459 111103 34827356
Glomerulonephropathy 25.83 19.93 8 18464 216 34938243
Diffuse mesangial sclerosis 25.01 19.93 6 18466 59 34938400
Erythema 24.80 19.93 8 18464 88772 34849687
Hyperplasia 24.77 19.93 10 18462 594 34937865
Cerebral aspergillosis 24.73 19.93 13 18459 1419 34937040
Urinary tract infection enterococcal 24.35 19.93 11 18461 862 34937597
Cerebral ventricle collapse 24.32 19.93 6 18466 67 34938392
Post procedural urine leak 24.31 19.93 7 18465 146 34938313
Constipation 24.25 19.93 22 18450 136960 34801499
Optic discs blurred 24.24 19.93 6 18466 68 34938391
Pneumonia cryptococcal 23.98 19.93 11 18461 893 34937566
Acinetobacter infection 23.86 19.93 12 18460 1195 34937264
White blood cell count increased 23.71 19.93 61 18411 41090 34897369
Paraesthesia 23.66 19.93 3 18469 64169 34874290
Central nervous system infection 23.62 19.93 10 18462 670 34937789
Lymphorrhoea 23.56 19.93 6 18466 77 34938382
Pelvic fluid collection 23.46 19.93 7 18465 166 34938293
Graft thrombosis 23.43 19.93 8 18464 296 34938163
Immunosuppressant drug level decreased 23.42 19.93 12 18460 1242 34937217
Aplasia pure red cell 23.39 19.93 22 18450 6110 34932349
Endocarditis bacterial 23.19 19.93 11 18461 964 34937495
Pyelonephritis 23.14 19.93 22 18450 6193 34932266
Cytomegalovirus enterocolitis 22.99 19.93 11 18461 983 34937476
Inappropriate schedule of product administration 22.76 19.93 3 18469 62293 34876166
Human herpesvirus 6 infection 22.72 19.93 14 18458 2067 34936392
Vomiting 22.67 19.93 62 18410 247559 34690900
Stenotrophomonas infection 22.54 19.93 14 18458 2096 34936363
Splenic infection fungal 22.51 19.93 6 18466 93 34938366
Erosive duodenitis 22.47 19.93 13 18459 1711 34936748
Pneumocystis jirovecii infection 22.15 19.93 13 18459 1757 34936702
Joint swelling 21.60 19.93 3 18469 59887 34878572
Cytomegalovirus gastroenteritis 21.59 19.93 7 18465 220 34938239
Infection reactivation 21.42 19.93 12 18460 1486 34936973
Urinoma 21.38 19.93 7 18465 227 34938232
Drug hypersensitivity 21.22 19.93 8 18464 80521 34857938
Peritonitis 21.21 19.93 34 18438 16331 34922128
Splenic necrosis 21.17 19.93 6 18466 118 34938341
Weight decreased 21.17 19.93 38 18434 176263 34762196
Enamel anomaly 21.12 19.93 6 18466 119 34938340
Complications of transplanted liver 21.12 19.93 7 18465 236 34938223
Myalgia 21.11 19.93 9 18463 84101 34854358
Hepatic artery thrombosis 20.98 19.93 7 18465 241 34938218
Pulmonary nocardiosis 20.85 19.93 10 18462 898 34937561
Gonococcal infection 20.77 19.93 5 18467 50 34938409
Bacterial pyelonephritis 20.71 19.93 7 18465 251 34938208
Dengue fever 20.66 19.93 7 18465 253 34938206
Urticaria 20.55 19.93 4 18468 62373 34876086
Graft infection 20.16 19.93 8 18464 454 34938005

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Kidney transplant rejection 1569.67 21.22 416 27393 9830 79706749
Transplant rejection 1208.02 21.22 392 27417 19045 79697534
Cytomegalovirus infection 1143.99 21.22 462 27347 42182 79674397
Complications of transplanted kidney 863.79 21.22 235 27574 6131 79710448
Polyomavirus-associated nephropathy 811.67 21.22 218 27591 5409 79711170
Delayed graft function 478.13 21.22 130 27679 3377 79713202
Thrombotic microangiopathy 463.85 21.22 196 27613 19973 79696606
Post transplant lymphoproliferative disorder 355.05 21.22 138 27671 11326 79705253
Renal tubular necrosis 343.90 21.22 170 27639 24869 79691710
Multiple organ dysfunction syndrome 343.38 21.22 305 27504 119941 79596638
Mucormycosis 335.18 21.22 122 27687 8347 79708232
Immunosuppressant drug level increased 313.01 21.22 118 27691 8909 79707670
BK virus infection 283.36 21.22 109 27700 8695 79707884
Blood creatinine increased 283.09 21.22 308 27501 154749 79561830
Cytomegalovirus viraemia 272.93 21.22 118 27691 12703 79703876
Focal segmental glomerulosclerosis 268.59 21.22 82 27727 3239 79713340
Strongyloidiasis 268.02 21.22 85 27724 3813 79712766
Parvovirus B19 infection 245.09 21.22 64 27745 1416 79715163
Fatigue 219.67 21.22 32 27777 929695 78786884
Renal impairment 216.94 21.22 271 27538 157512 79559067
Transplant dysfunction 216.77 21.22 85 27724 7136 79709443
Nephropathy toxic 215.04 21.22 116 27693 20303 79696276
Aspergillus infection 207.80 21.22 111 27698 19050 79697529
Chronic allograft nephropathy 203.54 21.22 57 27752 1654 79714925
Incision site pain 187.50 21.22 60 27749 2770 79713809
Posterior reversible encephalopathy syndrome 172.71 21.22 110 27699 26171 79690408
Leukopenia 169.53 21.22 206 27603 116307 79600272
Graft versus host disease 165.61 21.22 88 27721 14938 79701641
Liver transplant rejection 155.86 21.22 54 27755 3194 79713385
Fall 155.44 21.22 3 27806 487626 79228953
Enterococcal infection 153.90 21.22 85 27724 15575 79701004
Renal transplant failure 153.83 21.22 47 27762 1860 79714719
Tubulointerstitial nephritis 152.82 21.22 118 27691 38117 79678462
Complications of transplanted lung 152.63 21.22 35 27774 439 79716140
Transplant failure 151.26 21.22 58 27751 4583 79711996
Klebsiella infection 145.42 21.22 82 27727 15638 79700941
Pain 145.04 21.22 34 27775 703768 79012811
Kidney fibrosis 143.86 21.22 52 27757 3483 79713096
Lymphocyte count decreased 142.87 21.22 124 27685 47165 79669414
Arthralgia 141.15 21.22 17 27792 571786 79144793
Pseudomonas infection 136.12 21.22 87 27722 20816 79695763
Pneumocystis jirovecii pneumonia 135.78 21.22 103 27706 32405 79684174
Epstein-Barr virus infection 135.52 21.22 76 27733 14340 79702239
Nausea 132.28 21.22 86 27723 957110 78759469
Product use in unapproved indication 129.62 21.22 276 27533 250083 79466496
Hyperammonaemia 128.01 21.22 67 27742 11026 79705553
Lymphocele 125.32 21.22 39 27770 1642 79714937
Dizziness 121.98 21.22 19 27790 526422 79190157
Bronchopulmonary aspergillosis 121.42 21.22 83 27726 22211 79694368
Neutrophil count increased 120.26 21.22 92 27717 29304 79687275
Renal tubular atrophy 117.43 21.22 38 27771 1818 79714761
Cytomegalovirus colitis 105.88 21.22 45 27764 4640 79711939
Respiratory failure 104.81 21.22 209 27600 180702 79535877
Escherichia infection 102.70 21.22 69 27740 17948 79698631
Ureteric stenosis 102.53 21.22 32 27777 1360 79715219
Headache 101.18 21.22 51 27758 653721 79062858
Scedosporium infection 100.65 21.22 32 27777 1446 79715133
Hydronephrosis 99.86 21.22 67 27742 17387 79699192
Rash 99.08 21.22 39 27770 578319 79138260
Adenovirus infection 97.41 21.22 51 27758 8396 79708183
Red blood cells urine positive 96.91 21.22 43 27766 4920 79711659
Glomerulonephritis 94.61 21.22 38 27771 3395 79713184
Pruritus 94.23 21.22 13 27796 394635 79321944
Dyspnoea 92.33 21.22 98 27711 856927 78859652
Ventricular remodelling 90.47 21.22 18 27791 107 79716472
Candida infection 89.65 21.22 87 27722 38127 79678452
Death 89.42 21.22 43 27766 566471 79150108
Malacoplakia 88.65 21.22 24 27785 612 79715967
Joint swelling 87.29 21.22 3 27806 288643 79427936
Cerebral aspergillosis 86.72 21.22 30 27779 1766 79714813
Anuria 86.60 21.22 66 27743 20897 79695682
Cytomegalovirus test positive 86.45 21.22 42 27767 5905 79710674
Drug resistance 85.97 21.22 89 27720 42124 79674455
Disseminated intravascular coagulation 84.83 21.22 82 27727 35760 79680819
Blood urea increased 83.79 21.22 94 27715 48696 79667883
Protein urine present 83.51 21.22 49 27760 10063 79706516
JC virus infection 83.49 21.22 36 27773 3845 79712734
Renal graft infection 82.53 21.22 22 27787 528 79716051
Haemolytic uraemic syndrome 81.93 21.22 37 27772 4412 79712167
Graft loss 81.13 21.22 25 27784 1018 79715561
Hypersensitivity 78.34 21.22 3 27806 262236 79454343
Pneumonia cytomegaloviral 78.02 21.22 37 27772 4932 79711647
Malaise 77.55 21.22 37 27772 489832 79226747
Renal tubular injury 75.77 21.22 26 27783 1493 79715086
Human herpesvirus 6 infection 75.29 21.22 37 27772 5333 79711246
Glomerulosclerosis 75.20 21.22 24 27785 1098 79715481
Herpes simplex 75.09 21.22 49 27760 12138 79704441
Distributive shock 74.94 21.22 30 27779 2657 79713922
Pathogen resistance 74.80 21.22 52 27757 14290 79702289
Product dose omission issue 73.37 21.22 3 27806 247534 79469045
Human ehrlichiosis 72.89 21.22 20 27789 537 79716042
Proteinuria 72.52 21.22 72 27737 32430 79684149
Urinary fistula 72.24 21.22 14 27795 71 79716508
Enterobacter infection 71.72 21.22 34 27775 4528 79712051
Cytomegalovirus infection reactivation 71.36 21.22 42 27767 8674 79707905
Oliguria 71.03 21.22 53 27756 16256 79700323
Drug hypersensitivity 70.96 21.22 10 27799 298906 79417673
Diabetes mellitus 70.61 21.22 110 27699 78280 79638299
Mycoplasma infection 70.32 21.22 21 27788 768 79715811
Urinary tract infection 69.43 21.22 232 27577 274280 79442299
Human herpesvirus 8 infection 69.21 21.22 23 27786 1197 79715382
Septic shock 68.83 21.22 140 27669 122661 79593918
Acute respiratory distress syndrome 67.43 21.22 80 27729 43987 79672592
Asthenia 66.41 21.22 49 27760 511640 79204939
Sepsis 65.75 21.22 225 27584 269203 79447376
Graft versus host disease in skin 65.31 21.22 35 27774 6038 79710541
Capillaritis 65.29 21.22 16 27793 271 79716308
Pancreatitis haemorrhagic 65.01 21.22 20 27789 810 79715769
Pain in extremity 65.00 21.22 23 27786 364515 79352064
Atypical haemolytic uraemic syndrome 64.76 21.22 21 27788 1011 79715568
Ureaplasma infection 64.41 21.22 21 27788 1029 79715550
Urine output decreased 64.20 21.22 52 27757 17970 79698609
Hepatitis C 63.98 21.22 44 27765 11881 79704698
Viraemia 62.99 21.22 27 27782 2842 79713737
Graft complication 62.72 21.22 19 27790 730 79715849
Polyomavirus viraemia 61.65 21.22 23 27786 1684 79714895
Insomnia 61.09 21.22 7 27802 245163 79471416
Intestine transplant rejection 59.66 21.22 12 27797 76 79716503
Peripheral swelling 59.55 21.22 11 27798 269606 79446973
Oedematous kidney 59.17 21.22 14 27795 203 79716376
Infusion related reaction 58.83 21.22 6 27803 230231 79486348
Diffuse large B-cell lymphoma 58.61 21.22 42 27767 12107 79704472
Passenger lymphocyte syndrome 55.75 21.22 12 27797 110 79716469
Herpes simplex hepatitis 55.12 21.22 16 27793 529 79716050
Systemic candida 54.07 21.22 32 27777 6674 79709905
IgA nephropathy 53.72 21.22 21 27788 1747 79714832
Haemophagocytic lymphohistiocytosis 53.64 21.22 51 27758 21786 79694793
Renal tubular disorder 52.43 21.22 31 27778 6455 79710124
Depression 52.03 21.22 7 27802 216783 79499796
Diffuse alveolar damage 51.02 21.22 25 27784 3579 79713000
Acute graft versus host disease 51.01 21.22 36 27773 10131 79706448
Graft versus host disease in gastrointestinal tract 50.39 21.22 30 27779 6326 79710253
Sinusitis 50.19 21.22 5 27804 195496 79521083
Infectious pleural effusion 50.12 21.22 25 27784 3719 79712860
Microsporidia infection 50.00 21.22 17 27792 949 79715630
Epstein-Barr viraemia 49.23 21.22 21 27788 2184 79714395
Cryptococcosis 48.77 21.22 24 27785 3469 79713110
Renal haemorrhage 48.77 21.22 21 27788 2235 79714344
Nocardiosis 48.16 21.22 28 27781 5651 79710928
Rhodococcus infection 48.11 21.22 13 27796 329 79716250
Drug level increased 47.94 21.22 64 27745 39587 79676992
Abdominal discomfort 47.89 21.22 14 27795 250713 79465866
Pyelonephritis 47.03 21.22 46 27763 20342 79696237
Weight increased 46.92 21.22 19 27790 277367 79439212
Urticaria 46.86 21.22 5 27804 185196 79531383
Gastrointestinal stromal tumour 46.81 21.22 19 27790 1744 79714835
Back pain 46.53 21.22 24 27785 304156 79412423
Hyperuricaemia 46.22 21.22 36 27773 11763 79704816
Mycobacterium abscessus infection 46.10 21.22 17 27792 1205 79715374
Lung transplant rejection 45.86 21.22 18 27791 1513 79715066
Nephropathy 45.45 21.22 33 27776 9705 79706874
Schistosomiasis 45.45 21.22 9 27800 52 79716527
Disseminated tuberculosis 44.68 21.22 24 27785 4159 79712420
Gait disturbance 44.68 21.22 9 27800 207497 79509082
Immunosuppressant drug level decreased 44.46 21.22 19 27790 1985 79714594
Lymphopenia 44.32 21.22 54 27755 30503 79686076
Vomiting 44.16 21.22 105 27704 665723 79050856
Oedematous pancreatitis 43.14 21.22 16 27793 1152 79715427
Bacteraemia 42.81 21.22 55 27754 32769 79683810
Syncope 42.57 21.22 6 27803 179443 79537136
Acid base balance abnormal 42.46 21.22 12 27797 360 79716219
Diabetic macroangiopathy 42.45 21.22 10 27799 142 79716437
Biloma 42.13 21.22 10 27799 147 79716432
Chest pain 42.11 21.22 23 27786 282281 79434298
Nasopharyngitis 41.95 21.22 18 27791 253863 79462716
Infective aneurysm 41.66 21.22 15 27794 993 79715586
Intracranial infection 41.38 21.22 9 27800 87 79716492
Ureteral necrosis 40.58 21.22 9 27800 96 79716483
Hypoaesthesia 40.27 21.22 7 27802 179345 79537234
Graft thrombosis 40.20 21.22 12 27797 438 79716141
Renal artery stenosis 40.08 21.22 21 27788 3461 79713118
Cerebrovascular accident 39.78 21.22 4 27805 155288 79561291
Swelling 39.76 21.22 13 27796 216698 79499881
Nephrosclerosis 39.44 21.22 17 27792 1813 79714766
Mastitis bacterial 38.59 21.22 8 27801 60 79716519
Leiomyosarcoma 38.45 21.22 11 27798 345 79716234
Renal cortical necrosis 38.33 21.22 11 27798 349 79716230
Aplasia pure red cell 37.67 21.22 27 27782 7783 79708796
Pancytopenia 37.43 21.22 135 27674 165610 79550969
Escherichia urinary tract infection 37.25 21.22 34 27775 13791 79702788
Post procedural urine leak 37.15 21.22 9 27800 145 79716434
End stage renal disease 36.79 21.22 32 27777 12188 79704391
Arteritis infective 36.63 21.22 8 27801 79 79716500
Disseminated aspergillosis 36.53 21.22 14 27795 1104 79715475
Sphincter of Oddi dysfunction 36.33 21.22 11 27798 422 79716157
Mediastinitis 36.24 21.22 13 27796 851 79715728
Myalgia 36.11 21.22 10 27799 185631 79530948
Hyperhidrosis 36.08 21.22 5 27804 151487 79565092
Cough 36.02 21.22 45 27764 366744 79349835
Pulmonary mucormycosis 35.97 21.22 14 27795 1151 79715428
Alopecia 35.75 21.22 18 27791 231337 79485242
Renal adenoma 35.57 21.22 7 27802 39 79716540
Abdominal wall abscess 35.53 21.22 14 27795 1189 79715390
Enterovirus infection 35.24 21.22 16 27793 1931 79714648
Abdominal pain upper 35.21 21.22 17 27792 223802 79492777
Glomerulonephropathy 35.10 21.22 10 27799 309 79716270
Shock 34.94 21.22 58 27751 43490 79673089
White blood cell count increased 34.79 21.22 79 27730 74554 79642025
Skin necrosis 34.78 21.22 37 27772 18050 79698529
Tongue necrosis 34.71 21.22 7 27802 45 79716534
Cytomegalovirus enterocolitis 34.45 21.22 15 27794 1640 79714939
Erosive duodenitis 33.96 21.22 16 27793 2101 79714478
Systemic mycosis 33.34 21.22 17 27792 2649 79713930
Renal vein thrombosis 33.33 21.22 11 27798 560 79716019
Renal haematoma 33.20 21.22 12 27797 803 79715776
Kidney rupture 33.00 21.22 9 27800 236 79716343
Inappropriate schedule of product administration 32.81 21.22 4 27805 133624 79582955
Post transplant distal limb syndrome 32.80 21.22 11 27798 589 79715990
Fungal infection 32.69 21.22 55 27754 41693 79674886
Weight decreased 32.41 21.22 46 27763 355152 79361427
Restrictive allograft syndrome 32.33 21.22 6 27803 23 79716556
Fungaemia 32.11 21.22 20 27789 4571 79712008
Pericarditis constrictive 32.07 21.22 11 27798 631 79715948
Bone marrow failure 31.91 21.22 61 27748 51046 79665533
Constipation 31.89 21.22 31 27778 283019 79433560
Donor specific antibody present 31.81 21.22 9 27800 271 79716308
Disease recurrence 31.77 21.22 56 27753 44053 79672526
Condition aggravated 31.63 21.22 81 27728 501043 79215536
Hepatitis A 31.28 21.22 12 27797 949 79715630
Right ventricular diastolic collapse 31.04 21.22 7 27802 81 79716498
Cardiac failure congestive 31.01 21.22 6 27803 142396 79574183
Ureteric dilatation 30.80 21.22 8 27801 173 79716406
Erythema 30.74 21.22 20 27789 223270 79493309
Corynebacterium infection 30.72 21.22 13 27796 1325 79715254
Pancreatitis acute 30.72 21.22 59 27750 49545 79667034
Decreased appetite 30.60 21.22 45 27764 342373 79374206
Pyrexia 30.53 21.22 366 27443 678343 79038236
Disseminated mucormycosis 30.42 21.22 11 27798 737 79715842
Complications of transplant surgery 30.29 21.22 11 27798 746 79715833
Discomfort 30.26 21.22 4 27805 125613 79590966
Adenoviral haemorrhagic cystitis 30.19 21.22 10 27799 515 79716064
Haemolytic anaemia 30.01 21.22 34 27775 17786 79698793
Drug level fluctuating 29.99 21.22 11 27798 768 79715811
Acinetobacter infection 29.85 21.22 16 27793 2761 79713818
Trichodysplasia spinulosa 29.81 21.22 11 27798 781 79715798
American trypanosomiasis 29.68 21.22 9 27800 347 79716232
Renal arteritis 29.66 21.22 5 27804 9 79716570
Hepatitis cholestatic 29.63 21.22 30 27779 13822 79702757
Arterial rupture 29.49 21.22 11 27798 805 79715774
Human herpesvirus 6 infection reactivation 29.30 21.22 10 27799 565 79716014
Acute graft versus host disease in skin 29.20 21.22 23 27786 7635 79708944
Malignant neoplasm progression 29.05 21.22 6 27803 135984 79580595
Transitional cell carcinoma metastatic 28.95 21.22 6 27803 45 79716534
Ascites 28.80 21.22 74 27735 75488 79641091
Acute kidney injury 28.79 21.22 292 27517 519112 79197467
Haemoglobin decreased 28.71 21.22 153 27656 221966 79494613
Glomerulonephritis membranoproliferative 28.51 21.22 10 27799 613 79715966
Paraesthesia 28.33 21.22 13 27796 176310 79540269
Hyperplasia 28.29 21.22 12 27797 1231 79715348
Complications of transplanted liver 28.25 21.22 9 27800 409 79716170
Blood glucose increased 27.97 21.22 96 27713 114879 79601700
Infection reactivation 27.70 21.22 15 27794 2642 79713937
Pleural effusion 27.59 21.22 112 27697 145150 79571429
Myocardial infarction 27.44 21.22 15 27794 184114 79532465
Drug intolerance 27.42 21.22 31 27778 264088 79452491
Intra-abdominal haemorrhage 27.34 21.22 18 27791 4522 79712057
West Nile viral infection 27.29 21.22 11 27798 991 79715588
Urinary tract infection enterococcal 27.29 21.22 16 27793 3279 79713300
Renal necrosis 27.29 21.22 8 27801 274 79716305
Wound 27.28 21.22 4 27805 116175 79600404
Diffuse mesangial sclerosis 26.97 21.22 6 27803 65 79716514
Arthritis 26.87 21.22 4 27805 114876 79601703
Transient acantholytic dermatosis 26.79 21.22 7 27802 155 79716424
Cryptosporidiosis infection 26.79 21.22 10 27799 733 79715846
Encephalitis Japanese B 26.72 21.22 6 27803 68 79716511
Optic discs blurred 26.72 21.22 6 27803 68 79716511
Epstein-Barr virus associated lymphoproliferative disorder 26.26 21.22 16 27793 3516 79713063
Peritonitis 26.15 21.22 40 27769 27996 79688583
Hepatic artery thrombosis 26.12 21.22 8 27801 319 79716260
Pneumonia cryptococcal 25.86 21.22 12 27797 1523 79715056
Lymphocytic infiltration 25.72 21.22 12 27797 1541 79715038
Neutropenia 25.65 21.22 180 27629 287530 79429049
Wound dehiscence 25.56 21.22 20 27789 6575 79710004
Bacterial pyelonephritis 25.53 21.22 9 27800 560 79716019
Anaemia 25.53 21.22 252 27557 444763 79271816
Gastroenteritis norovirus 25.51 21.22 15 27794 3091 79713488
Wheezing 25.23 21.22 5 27804 116659 79599920
Nephrectomy 25.04 21.22 13 27796 2102 79714477
Hypoglycaemia 25.04 21.22 3 27806 101591 79614988
Fungal skin infection 24.91 21.22 19 27790 6017 79710562
Somnolence 24.85 21.22 28 27781 238953 79477626
Ureteric anastomosis complication 24.81 21.22 5 27804 32 79716547
Renal injury 24.69 21.22 30 27779 16897 79699682
Confusional state 24.49 21.22 46 27763 317951 79398628
Coccidioidomycosis 24.44 21.22 11 27798 1301 79715278
Bilirubin conjugated increased 24.11 21.22 18 27791 5521 79711058
Febrile neutropenia 24.09 21.22 27 27782 230972 79485607
Splenic infection fungal 23.99 21.22 6 27803 111 79716468
Blood pressure increased 23.97 21.22 23 27786 211337 79505242
Pneumocystis jirovecii infection 23.83 21.22 14 27795 2880 79713699
General physical health deterioration 23.78 21.22 37 27772 275201 79441378
Herpes simplex viraemia 23.59 21.22 8 27801 443 79716136
Graft infection 23.58 21.22 9 27800 702 79715877
Granuloma 23.52 21.22 21 27788 8276 79708303
Escherichia bacteraemia 23.51 21.22 19 27790 6543 79710036
Cerebral ventricle collapse 23.50 21.22 6 27803 121 79716458
Hepatitis E 23.43 21.22 14 27795 2972 79713607
Blood albumin decreased 23.19 21.22 35 27774 24208 79692371
Sinusitis aspergillus 23.18 21.22 7 27802 266 79716313
Pneumonia bacterial 23.05 21.22 31 27778 19300 79697279
Endocarditis bacterial 22.83 21.22 11 27798 1518 79715061
Dyslipidaemia 22.73 21.22 24 27785 11609 79704970
Encephalopathy 22.65 21.22 63 27746 67334 79649245
Argentine haemorrhagic fever 22.31 21.22 4 27805 12 79716567
Lymphorrhoea 22.20 21.22 6 27803 152 79716427
Renal vessel disorder 22.17 21.22 7 27802 309 79716270
Guillain-Barre syndrome 22.13 21.22 21 27788 8944 79707635
Brain oedema 22.10 21.22 35 27774 25228 79691351
Cytomegalovirus chorioretinitis 22.04 21.22 17 27792 5473 79711106
Ureteric obstruction 22 21.22 13 27796 2703 79713876
Bronchitis 21.99 21.22 9 27800 130635 79585944
Hyperglycaemia 21.94 21.22 64 27745 70271 79646308
Stomatitis 21.80 21.22 12 27797 146745 79569834
Pneumonia fungal 21.68 21.22 23 27786 11187 79705392
Procedural pain 21.62 21.22 33 27776 23051 79693528
Acid fast bacilli infection 21.56 21.22 6 27803 170 79716409
Hepatic cyst infection 21.56 21.22 6 27803 170 79716409
Progressive multifocal leukoencephalopathy 21.52 21.22 31 27778 20569 79696010
Splenic necrosis 21.46 21.22 6 27803 173 79716406
Renal artery perforation 21.41 21.22 4 27805 16 79716563
Pulmonary nocardiosis 21.31 21.22 10 27799 1301 79715278
Gonococcal infection 21.29 21.22 5 27804 70 79716509

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000010279 Interleukin 2 Receptor Antagonists
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA MoA N0000175621 Interleukin 2 Receptor-directed Antibody Interactions
FDA EPC N0000175622 Interleukin-2 Receptor Blocking Antibody

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Renal transplant rejection indication 236570004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-2 receptor subunit alpha Membrane receptor ANTIBODY BINDING Kd 10 DRUG LABEL DRUG LABEL

External reference:

IDSource
D03058 KEGG_DRUG
4021113 VUID
N0000148568 NUI
4021113 VANDF
CHEMBL1201439 ChEMBL_ID
6879 IUPHAR_LIGAND_ID
DB00074 DRUGBANK_ID
196102 RXNORM
11703 MMSL
4246 MMSL
d04314 MMSL
007552 NDDF
109135008 SNOMEDCT_US
386978004 SNOMEDCT_US
C0676831 UMLSCUI
D000077552 MESH_DESCRIPTOR_UI
7578 INN_ID
9927MT646M UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Simulect HUMAN PRESCRIPTION DRUG LABEL 1 0078-0331 INJECTION, POWDER, FOR SOLUTION 20 mg INTRAVENOUS BLA 24 sections
Simulect HUMAN PRESCRIPTION DRUG LABEL 1 0078-0331 INJECTION, POWDER, FOR SOLUTION 20 mg INTRAVENOUS BLA 24 sections
Simulect HUMAN PRESCRIPTION DRUG LABEL 1 0078-0331 INJECTION, POWDER, FOR SOLUTION 20 mg INTRAVENOUS BLA 24 sections
Simulect HUMAN PRESCRIPTION DRUG LABEL 1 0078-0393 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAVENOUS BLA 24 sections
Simulect HUMAN PRESCRIPTION DRUG LABEL 1 0078-0393 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAVENOUS BLA 24 sections
Simulect HUMAN PRESCRIPTION DRUG LABEL 1 0078-0393 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAVENOUS BLA 24 sections