carbenoxolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids not used as glucocorticosteroids	493	5697-56-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carbenoxolone biogastrone glycyrrhetinic acid hydrogen succinate carbenoxolone disodium salt carbenoxolone disodium carbenoxolone sodium	An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. Molecular weight: 570.77 Formula: C34H50O7 CLOGP: 7.19 LIPINSKI: 2 HAC: 7 HDO: 2 TPSA: 117.97 ALOGS: -5.89 ROTB: 6

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carbenoxolone
biogastrone
glycyrrhetinic acid hydrogen succinate
carbenoxolone disodium salt
carbenoxolone disodium
carbenoxolone sodium

An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.

Molecular weight: 570.77
Formula: C34H50O7
CLOGP: 7.19
LIPINSKI: 2
HAC: 7
HDO: 2
TPSA: 117.97
ALOGS: -5.89
ROTB: 6

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02BX01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
ATC	A02BX51	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
ATC	A02BX71	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
MeSH PA	D000897	Anti-Ulcer Agents
MeSH PA	D005765	Gastrointestinal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Ulcer of esophagus	indication	30811009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.29	acidic
pKa2	5.02	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	P28845	DHI1_HUMAN	INHIBITOR	IC50	7.08	CHEMBL	KEGG DRUG
Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme		DHI1_MOUSE		IC50	6.97	CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme		DHI2_MOUSE		IC50	7.09	CHEMBL
Pannexin-1	Unclassified		PANX1_MOUSE		IC50	5	CHEMBL

External reference:

ID	Source
N0000166341	NUI
D01899	KEGG_DRUG
2017	RXNORM
C0006979	UMLSCUI
CHEBI:31351	CHEBI
CBO	PDB_CHEM_ID
CHEMBL499915	ChEMBL_ID
CHEMBL1697717	ChEMBL_ID
D002229	MESH_DESCRIPTOR_UI
DB02329	DRUGBANK_ID
4151	IUPHAR_LIGAND_ID
1789	INN_ID
7421-40-1	SECONDARY_CAS_RN
MM6384NG73	UNII
636403	PUBCHEM_CID
387273006	SNOMEDCT_US
395820002	SNOMEDCT_US
49617001	SNOMEDCT_US
003685	NDDF
003686	NDDF

Pharmaceutical products:

None