parathyroid hormone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4936 68893-82-3

Description:

MoleculeDescription

Synonyms:

  • parathyroid hormone
  • natpara
  • human parathyroid hormone
  • human recombinant parathyroid hormone
  • parathormone
  • ALX1-11
  • rhPTH
  • parathyrin
  • preotact
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
  • Molecular weight: 9424.76
  • Formula: C408H674N126O126S2
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 4123.69
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.10 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2015 FDA NPS PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Recalled product 2228.45 37.60 319 4007 898 46680838
Blood calcium decreased 1209.22 37.60 281 4045 15392 46666344
Hypocalcaemia 936.22 37.60 255 4071 26530 46655206
Inappropriate schedule of product administration 380.15 37.60 162 4164 64851 46616885
Blood calcium abnormal 377.90 37.60 66 4260 796 46680940
Tetany 300.60 37.60 61 4265 1710 46680026
Blood calcium increased 253.32 37.60 70 4256 7517 46674219
Muscle spasms 252.72 37.60 151 4175 122962 46558774
Paraesthesia 235.65 37.60 142 4184 117295 46564441
Bone pain 118.35 37.60 66 4260 46824 46634912
Hypoparathyroidism 96.12 37.60 20 4306 633 46681103
Product dose omission issue 89.26 37.60 93 4233 168427 46513309
Hypercalcaemia 71.05 37.60 36 4290 21010 46660726
Hypoaesthesia 69.01 37.60 69 4257 118800 46562936
Product availability issue 54.73 37.60 14 4312 1111 46680625
No adverse event 52.33 37.60 35 4291 34196 46647540
Nephrolithiasis 51.02 37.60 34 4292 33017 46648719
Impaired quality of life 43.99 37.60 15 4311 3227 46678509
Product supply issue 43.07 37.60 11 4315 867 46680869
Product distribution issue 42.18 37.60 9 4317 322 46681414
Product quality issue 41.80 37.60 31 4295 35617 46646119

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Recalled product 390.33 49.78 47 322 324 29951785
Hypocalcaemia 173.74 49.78 42 327 21334 29930775
Blood calcium decreased 115.37 49.78 26 343 9536 29942573
Blood calcium abnormal 50.31 49.78 8 361 441 29951668

Pharmacologic Action:

SourceCodeDescription
ATC H05AA03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
PARATHYROID HORMONES AND ANALOGUES
Parathyroid hormones and analogues
FDA CS M0015931 Parathyroid Hormone
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
FDA EPC N0000180851 Parathyroid Hormone

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypoparathyroidism indication 36976004 DOID:11199

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Parathyroid hormone/parathyroid hormone-related peptide receptor GPCR AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D05364 KEGG_DRUG
4034355 VUID
N0000191550 NUI
9002-64-6 SECONDARY_CAS_RN
4034355 VANDF
C3883368 UMLSCUI
CHEMBL2108078 ChEMBL_ID
D010281 MESH_DESCRIPTOR_UI
DB05829 DRUGBANK_ID
8441 INN_ID
N19A0T0E5J UNII
1427222 RXNORM
232515 MMSL
23408 MMSL
d06650 MMSL
002141 NDDF
27518004 SNOMEDCT_US
373752003 SNOMEDCT_US
4076007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NULLTPARA (parathyroid hormone) HUMAN PRESCRIPTION DRUG LABEL 1 68875-0202 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 25 ug SUBCUTANEOUS BLA 30 sections
NULLTPARA (parathyroid hormone) HUMAN PRESCRIPTION DRUG LABEL 1 68875-0203 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 ug SUBCUTANEOUS BLA 30 sections
NULLTPARA (parathyroid hormone) HUMAN PRESCRIPTION DRUG LABEL 1 68875-0204 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 75 ug SUBCUTANEOUS BLA 30 sections
NULLTPARA (parathyroid hormone) HUMAN PRESCRIPTION DRUG LABEL 1 68875-0205 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 ug SUBCUTANEOUS BLA 30 sections