All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

parathyroid hormone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4936	68893-82-3

Description:

Molecule

Description

Synonyms: parathyroid hormone natpara human parathyroid hormone human recombinant parathyroid hormone parathormone ALX1-11 rhPTH parathyrin preotact

A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Molecular weight: 9424.76 Formula: C408H674N126O126S2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 4123.69 ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.10	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Jan. 23, 2015	FDA	NPS PHARMS INC
April 24, 2017	EMA	TAKEDA PHARMACEUTICALS INTERNATIONAL AG IRELAND BRANCH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Recalled product	2757.10	34.08	373	5338	1015	90621721
Blood calcium decreased	1341.45	34.08	322	5389	29860	90592876
Hypocalcaemia	1160.59	34.08	307	5404	42061	90580675
Blood calcium abnormal	509.87	34.08	91	5620	1886	90620850
Tetany	367.22	34.08	72	5639	2512	90620224
Inappropriate schedule of product administration	344.75	34.08	174	5537	149759	90472977
Blood calcium increased	336.38	34.08	89	5622	11969	90610767
Muscle spasms	287.73	34.08	185	5526	251698	90371038
Paraesthesia	244.85	34.08	167	5544	250159	90372577
Bone pain	212.82	34.08	95	5616	61888	90560848
Product dose omission issue	132.08	34.08	124	5587	291563	90331173
Hypercalcaemia	112.67	34.08	51	5660	34189	90588547
Nephrolithiasis	100.89	34.08	53	5658	49032	90573704
Product availability issue	75.05	34.08	25	5686	7379	90615357
Device issue	66.73	34.08	34	5677	29503	90593233
No adverse event	56.01	34.08	41	5670	67941	90554795
Hypoparathyroidism	51.06	34.08	12	5699	989	90621747
Product storage error	50.71	34.08	25	5686	20216	90602520
Hypoaesthesia	46.30	34.08	76	5635	314134	90308602
Urine calcium increased	43.40	34.08	7	5704	76	90622660
Product supply issue	42.24	34.08	13	5698	2979	90619757
Hypocalcaemic seizure	40.96	34.08	6	5705	32	90622704
Muscle twitching	38.28	34.08	22	5689	24180	90598556
Expired device used	37.95	34.08	9	5702	771	90621965
Calciphylaxis	36.62	34.08	12	5699	3364	90619372
Device leakage	36.42	34.08	16	5695	9975	90612761
Product quality issue	36.26	34.08	34	5677	79291	90543445
Product distribution issue	35.52	34.08	12	5699	3693	90619043
Blood magnesium decreased	35.24	34.08	18	5693	15675	90607061
Expired product administered	35.01	34.08	14	5697	6908	90615828

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Recalled product	482.65	44.61	58	527	340	42620410
Hypocalcaemia	202.07	44.61	52	533	30121	42590629
Blood calcium decreased	161.99	44.61	36	549	11072	42609678
Blood calcium abnormal	94.55	44.61	15	570	731	42620019

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Recalled product	1355.21	36.14	183	4220	867	110584029
Blood calcium decreased	1055.26	36.14	251	4152	35594	110549302
Hypocalcaemia	588.80	36.14	180	4223	65186	110519710
Inappropriate schedule of product administration	304.01	36.14	152	4251	203485	110381411
Blood calcium abnormal	298.43	36.14	53	4350	1716	110583180
Blood calcium increased	274.98	36.14	75	4328	17965	110566931
Tetany	254.87	36.14	52	4351	3552	110581344
Muscle spasms	254.19	36.14	150	4253	278007	110306889
Paraesthesia	223.80	36.14	138	4265	276383	110308513
Bone pain	204.53	36.14	82	4321	65051	110519845
Product dose omission issue	153.61	36.14	116	4287	321666	110263230
Hypercalcaemia	72.70	36.14	36	4367	46621	110538275
Device issue	63.95	36.14	30	4373	34505	110550391
Expired device used	60.96	36.14	12	4391	680	110584216
Nephrolithiasis	60.87	36.14	36	4367	66176	110518720
Product distribution issue	56.63	36.14	16	4387	4330	110580566
Hypoaesthesia	50.03	36.14	62	4341	314161	110270735
Blood magnesium decreased	42.11	36.14	19	4384	19977	110564919
Product storage error	40.60	36.14	19	4384	21709	110563187
Product availability issue	39.49	36.14	14	4389	7876	110577020

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	H05AA03	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CALCIUM HOMEOSTASIS PARATHYROID HORMONES AND ANALOGUES Parathyroid hormones and analogues
FDA CS	M0015931	Parathyroid Hormone
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
FDA EPC	N0000180851	Parathyroid Hormone

Related Drugs by ATC class:

H05AA Parathyroid hormones and analogues 3 drugs

abaloparatidepalopegteriparatideteriparatide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypoparathyroidism	indication	36976004	DOID:11199

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Parathyroid hormone/parathyroid hormone-related peptide receptor	GPCR	Q03431	PTH1R_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL
Parathyroid hormone 2 receptor	GPCR	P49190	PTH2R_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D05364	KEGG_DRUG
4034355	VUID
N0000191550	NUI
9002-64-6	SECONDARY_CAS_RN
4034355	VANDF
CHEMBL2108078	ChEMBL_ID
DB05829	DRUGBANK_ID
1427222	RXNORM
232515	MMSL
23408	MMSL
d06650	MMSL
002141	NDDF
4076007	SNOMEDCT_US
C0030520	UMLSCUI
D010281	MESH_DESCRIPTOR_UI
8441	INN_ID
N19A0T0E5J	UNII
N19A0T0E5J	INXIGHT DRUGS

Pharmaceutical products:

None