secukinumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
human origin 4934 1229022-83-6

Description:

MoleculeDescription

Synonyms:

  • secukinumab
  • cosentyx
  • AIN-457
  • AIN457
Secukinumab is a human IgG1 monoclonal antibody that selectively binds to the interleukin-17A (IL-17A) cytokine and inhibits its interaction with the IL-17 receptor. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Secukinumab inhibits the release of proinflammatory cytokines and chemokines.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 14, 2015 EMA NOVARTIS EUROPHARM LIMITED
Jan. 21, 2015 FDA NOVARTIS PHARMS CORP
Dec. 26, 2014 PMDA Novartis Pharma

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1203.85 15.14 5382 150156 1039383 62294101
Psoriasis 1111.42 15.14 1212 154326 85745 63247739
Psoriatic arthropathy 858.72 15.14 1089 154449 90431 63243053
Inappropriate schedule of product administration 834.79 15.14 1146 154392 102819 63230665
Incorrect dose administered 785.32 15.14 847 154691 59121 63274363
Liver injury 723.61 15.14 815 154723 59705 63273779
Musculoskeletal stiffness 535.67 15.14 1308 154230 183310 63150174
Toxicity to various agents 532.70 15.14 16 155522 247234 63086250
Device malfunction 531.59 15.14 401 155137 17456 63316028
Skin plaque 505.94 15.14 292 155246 8028 63325456
Acute kidney injury 468.58 15.14 50 155488 263365 63070119
Therapy interrupted 445.12 15.14 470 155068 31985 63301499
Hypotension 427.79 15.14 76 155462 272528 63060956
Drug interaction 406.17 15.14 44 155494 229087 63104397
Anaemia 405.45 15.14 109 155429 293321 63040163
Arthralgia 398.58 15.14 2569 152969 567141 62766343
Therapeutic product effect incomplete 369.81 15.14 893 154645 124163 63209321
Death 322.05 15.14 267 155271 374114 62959370
Neutropenia 316.81 15.14 31 155507 174974 63158510
Treatment failure 313.72 15.14 1136 154402 197907 63135577
Accidental exposure to product 311.98 15.14 360 155178 27045 63306439
Device issue 306.00 15.14 333 155205 23448 63310036
Skin exfoliation 293.91 15.14 440 155098 42662 63290822
Pain 279.63 15.14 2903 152635 737725 62595759
Fibromyalgia 265.73 15.14 600 154938 79820 63253664
Arthritis 248.58 15.14 735 154803 115186 63218298
Nasopharyngitis 246.23 15.14 1252 154286 253005 63080479
Constipation 235.33 15.14 129 155409 224814 63108670
Hyponatraemia 234.62 15.14 9 155529 111891 63221593
Incorrect dose administered by device 226.19 15.14 138 155400 4210 63329274
Macule 223.40 15.14 106 155432 1922 63331562
Arthropathy 222.29 15.14 1149 154389 233643 63099841
Skin lesion 221.51 15.14 322 155216 30399 63303085
Rheumatoid arthritis 220.48 15.14 1213 154325 252606 63080878
Glossodynia 217.94 15.14 942 154596 177934 63155550
Dyspnoea 213.52 15.14 866 154672 660447 62673037
Thrombocytopenia 210.75 15.14 55 155483 151102 63182382
Disease progression 208.90 15.14 27 155511 122731 63210753
Platelet count decreased 206.39 15.14 22 155516 116100 63217384
Product use issue 203.07 15.14 1071 154467 219449 63114035
Somnolence 202.63 15.14 92 155446 178593 63154891
Pemphigus 197.95 15.14 933 154605 182793 63150691
Skin haemorrhage 196.17 15.14 177 155361 9917 63323567
Dehydration 195.41 15.14 90 155448 173264 63160220
Systemic lupus erythematosus 195.34 15.14 1019 154519 207899 63125585
Wound 191.40 15.14 850 154688 162413 63171071
Haemoglobin decreased 189.79 15.14 60 155478 145425 63188059
Type 2 diabetes mellitus 188.52 15.14 456 155082 63412 63270072
Prescribed overdose 186.44 15.14 315 155223 33838 63299646
Malaise 185.94 15.14 1691 153847 414263 62919221
White blood cell count decreased 185.73 15.14 55 155483 139049 63194435
Malignant neoplasm progression 185.69 15.14 3 155535 82118 63251366
Enthesopathy 183.26 15.14 159 155379 8455 63325029
Drug intolerance 181.67 15.14 1336 154202 307325 63026159
Pancytopenia 181.20 15.14 15 155523 96918 63236566
Synovitis 180.48 15.14 920 154618 185998 63147486
Rheumatic fever 179.98 15.14 354 155184 42757 63290727
Inflammation 177.58 15.14 523 155015 81750 63251734
Cardiac arrest 173.88 15.14 14 155524 92531 63240953
Seronegative arthritis 169.30 15.14 111 155427 3848 63329636
Inflammatory bowel disease 168.94 15.14 111 155427 3862 63329622
Hypokalaemia 162.50 15.14 29 155509 103775 63229709
Abdominal discomfort 161.76 15.14 1340 154198 319545 63013939
Respiratory failure 160.45 15.14 28 155510 101830 63231654
Wrong technique in device usage process 159.05 15.14 103 155435 3495 63329989
Contraindicated product administered 158.36 15.14 993 154545 216655 63116829
Device defective 158.28 15.14 83 155455 1879 63331605
Therapeutic product effect decreased 158.16 15.14 909 154629 192278 63141206
Product storage error 157.79 15.14 189 155349 14767 63318717
Bradycardia 156.59 15.14 5 155533 73222 63260262
Mobility decreased 155.94 15.14 649 154889 120510 63212974
Renal failure 152.59 15.14 49 155489 117603 63215881
COVID-19 149.61 15.14 611 154927 112492 63220992
Drug abuse 148.11 15.14 7 155531 72511 63260973
Fall 147.92 15.14 481 155057 391853 62941631
Incorrect route of product administration 146.93 15.14 251 155287 27201 63306283
Therapeutic response shortened 145.18 15.14 162 155376 11726 63321758
Oxygen saturation decreased 142.52 15.14 23 155515 88562 63244922
Dislocation of vertebra 142.00 15.14 138 155400 8497 63324987
Seizure 140.17 15.14 75 155463 132559 63200925
Discomfort 139.89 15.14 792 154746 166582 63166902
Pruritus 138.94 15.14 1424 154114 360029 62973455
Swollen joint count increased 138.49 15.14 286 155252 35768 63297716
Hand deformity 138.22 15.14 762 154776 158695 63174789
C-reactive protein increased 137.64 15.14 527 155011 94180 63239304
Alopecia 137.55 15.14 1346 154192 336190 62997294
Cardiac failure 137.17 15.14 26 155512 89116 63244368
Pulmonary embolism 133.92 15.14 59 155479 116625 63216859
Depressed level of consciousness 133.60 15.14 4 155534 62074 63271410
Influenza 133.38 15.14 574 154964 108148 63225336
Oropharyngeal pain 132.61 15.14 520 155018 93967 63239517
Syncope 132.15 15.14 61 155477 117324 63216160
Joint swelling 131.72 15.14 1303 154235 326363 63007121
Osteoarthritis 130.01 15.14 520 155018 94823 63238661
Tremor 128.12 15.14 83 155455 132156 63201328
Injection site bruising 126.62 15.14 302 155236 41608 63291876
Rheumatoid factor positive 126.22 15.14 474 155064 83932 63249552
Pleural effusion 125.96 15.14 36 155502 93174 63240310
Cardio-respiratory arrest 125.05 15.14 5 155533 59954 63273530
Ear infection 124.91 15.14 284 155254 37929 63295555
Sepsis 124.38 15.14 115 155423 153008 63180476
Cardiac failure congestive 124.36 15.14 36 155502 92397 63241087
Tonsillitis 122.29 15.14 106 155432 5629 63327855
Intentional overdose 122.14 15.14 18 155520 74134 63259350
Gastrointestinal haemorrhage 122.12 15.14 25 155513 81151 63252333
Gait inability 119.38 15.14 342 155196 52617 63280867
Overdose 117.37 15.14 68 155470 115010 63218474
Hallucination 116.29 15.14 4 155534 54813 63278671
Loss of consciousness 115.99 15.14 73 155465 118048 63215436
Pericarditis 115.48 15.14 631 154907 130948 63202536
Retinitis 115.22 15.14 106 155432 6090 63327394
Maternal exposure during pregnancy 113.97 15.14 925 154613 219137 63114347
Uveitis 112.21 15.14 146 155392 12407 63321077
Blood cholesterol increased 111.16 15.14 491 155047 93541 63239943
Dactylitis 111.12 15.14 73 155465 2539 63330945
C-reactive protein abnormal 111.08 15.14 305 155233 45791 63287693
Blister 110.89 15.14 618 154920 129196 63204288
Injury 110.06 15.14 412 155126 72835 63260649
Ankylosing spondylitis 109.90 15.14 132 155406 10342 63323142
Coma 109.85 15.14 14 155524 64350 63269134
Duodenal ulcer perforation 109.71 15.14 464 155074 86745 63246739
Decreased immune responsiveness 109.41 15.14 93 155445 4808 63328676
Tachycardia 109.32 15.14 78 155460 118078 63215406
Neuropathy peripheral 109.21 15.14 72 155466 113595 63219889
Grip strength decreased 107.89 15.14 195 155343 22092 63311392
Balance disorder 106.24 15.14 37 155501 84385 63249099
Therapy non-responder 105.90 15.14 417 155121 75484 63258000
Papule 105.13 15.14 97 155441 5594 63327890
Intentional product misuse 104.57 15.14 13 155525 60904 63272580
Helicobacter infection 104.07 15.14 477 155061 92308 63241176
Atrial fibrillation 104.03 15.14 80 155458 116556 63216928
Multiple organ dysfunction syndrome 102.77 15.14 10 155528 56742 63276742
Hyperkalaemia 102.36 15.14 8 155530 54195 63279289
Facet joint syndrome 102.06 15.14 137 155401 12001 63321483
Lip dry 101.26 15.14 155 155383 15315 63318169
Illness 101.20 15.14 307 155231 48752 63284732
Hypoxia 99.67 15.14 14 155524 59778 63273706
Adjustment disorder with depressed mood 99.61 15.14 124 155414 10080 63323404
Needle issue 99.55 15.14 125 155413 10251 63323233
Skin fissures 99.54 15.14 131 155407 11257 63322227
Infection 96.22 15.14 920 154618 228253 63105231
Agitation 95.03 15.14 16 155522 59741 63273743
Metabolic acidosis 93.18 15.14 4 155534 45065 63288419
Bone erosion 92.19 15.14 160 155378 17557 63315927
Deep vein thrombosis postoperative 92.06 15.14 126 155412 11243 63322241
Wound infection 89.57 15.14 176 155362 21234 63312250
Interstitial lung disease 89.20 15.14 21 155517 61887 63271597
Anti-cyclic citrullinated peptide antibody positive 88.66 15.14 537 155001 115675 63217809
Hypoglycaemia 87.29 15.14 20 155518 60045 63273439
Multiple sclerosis relapse 86.58 15.14 9 155529 48469 63285015
Cognitive disorder 86.46 15.14 16 155522 55799 63277685
Joint stiffness 86.35 15.14 262 155276 41607 63291877
Nausea 84.72 15.14 1530 154008 852941 62480543
Pain in extremity 83.51 15.14 1206 154332 330280 63003204
Vomiting 83.44 15.14 923 154615 558694 62774790
Epistaxis 83.07 15.14 37 155501 72688 63260796
Hip arthroplasty 82.68 15.14 281 155257 47365 63286119
Pulmonary oedema 82.32 15.14 17 155521 54856 63278628
Bursitis 82.30 15.14 238 155300 36803 63296681
Mycotic allergy 82.25 15.14 43 155495 967 63332517
Peripheral venous disease 80.83 15.14 140 155398 15337 63318147
Joint dislocation 80.41 15.14 156 155382 18644 63314840
Laryngitis 80.28 15.14 147 155391 16820 63316664
Exostosis 79.82 15.14 151 155387 17711 63315773
Injection site haemorrhage 79.78 15.14 181 155357 24133 63309351
Red blood cell sedimentation rate 78.74 15.14 77 155461 4777 63328707
Rhinorrhoea 78.68 15.14 344 155194 65233 63268251
Lupus-like syndrome 78.11 15.14 137 155401 15158 63318326
Tonsillar ulcer 78.04 15.14 29 155509 274 63333210
Fear of injection 77.99 15.14 92 155446 7072 63326412
Autoimmune disorder 77.74 15.14 146 155392 17031 63316453
Lactic acidosis 77.20 15.14 4 155534 38283 63295201
Therapy cessation 76.86 15.14 205 155333 30252 63303232
Concomitant disease aggravated 76.84 15.14 103 155435 9009 63324475
Guttate psoriasis 76.28 15.14 32 155506 427 63333057
Pustular psoriasis 76.20 15.14 74 155464 4552 63328932
Red blood cell sedimentation rate increased 75.97 15.14 259 155279 43723 63289761
Hypersensitivity 75.75 15.14 1070 154468 291615 63041869
Product use in unapproved indication 75.66 15.14 720 154818 178360 63155124
Tenosynovitis 74.95 15.14 127 155411 13668 63319816
Suicide attempt 74.43 15.14 28 155510 60890 63272594
Septic shock 74.39 15.14 35 155503 66594 63266890
Pharyngitis streptococcal 74.22 15.14 110 155428 10562 63322922
Hyperglycaemia 74.19 15.14 8 155530 41859 63291625
Anti-cyclic citrullinated peptide antibody 73.92 15.14 87 155451 6671 63326813
Skin disorder 73.85 15.14 198 155340 29309 63304175
Drug reaction with eosinophilia and systemic symptoms 69.96 15.14 3 155535 33833 63299651
Osteonecrosis of jaw 69.79 15.14 4 155534 35119 63298365
Knee arthroplasty 69.39 15.14 290 155248 53916 63279568
Drug tolerance decreased 68.73 15.14 140 155398 17333 63316151
Hepatic function abnormal 68.70 15.14 6 155532 37136 63296348
Heart rate decreased 68.58 15.14 14 155524 45546 63287938
Swelling 67.77 15.14 998 154540 274380 63059104
Product prescribing error 67.40 15.14 178 155360 26111 63307373
Joint range of motion decreased 66.94 15.14 203 155335 32225 63301259
Dyspnoea exertional 66.83 15.14 32 155506 60270 63273214
Mental status changes 66.64 15.14 9 155529 39590 63293894
Tendonitis 66.57 15.14 148 155390 19467 63314017
Blood bilirubin increased 66.06 15.14 7 155531 37133 63296351
Hypercholesterolaemia 64.72 15.14 154 155384 21180 63312304
Respiratory arrest 64.01 15.14 4 155534 32641 63300843
Unresponsive to stimuli 63.83 15.14 5 155533 33811 63299673
Deep vein thrombosis 63.33 15.14 67 155471 83733 63249751
Plasma cell myeloma 63.27 15.14 7 155531 35898 63297586
Sinusitis 63.25 15.14 840 154698 225813 63107671
Foetal exposure during pregnancy 62.42 15.14 4 155534 31958 63301526
Pallor 62.25 15.14 3 155535 30565 63302919
Red blood cell count decreased 62.21 15.14 12 155526 40633 63292851
Hypocalcaemia 61.84 15.14 4 155534 31709 63301775
Mucosal inflammation 61.79 15.14 19 155519 46909 63286575
Neurologic neglect syndrome 61.49 15.14 52 155486 2669 63330815
Blood pressure decreased 61.35 15.14 42 155496 64980 63268504
Rebound psoriasis 60.50 15.14 19 155519 101 63333383
Leukopenia 60.45 15.14 60 155478 77230 63256254
Carotid artery thrombosis 60.29 15.14 52 155486 2742 63330742
Cholestasis 59.59 15.14 3 155535 29431 63304053
Night sweats 59.26 15.14 257 155281 48557 63284927
Pustule 59.25 15.14 42 155496 1657 63331827
Orthostatic hypotension 59.03 15.14 9 155529 36151 63297333
Adverse drug reaction 58.66 15.14 365 155173 79349 63254135
Thrombosis 58.25 15.14 44 155494 64711 63268773
Renal impairment 57.89 15.14 79 155459 88276 63245208
Pain of skin 57.85 15.14 103 155435 11531 63321953
Sinus congestion 57.34 15.14 133 155405 17990 63315494
Blood potassium decreased 57.19 15.14 16 155522 42010 63291474
Hypervolaemia 57.19 15.14 3 155535 28410 63305074
Dyskinesia 57.00 15.14 6 155532 31996 63301488
Pulmonary hypertension 56.73 15.14 11 155527 37112 63296372
Full blood count abnormal 56.35 15.14 6 155532 31711 63301773
Bone marrow failure 56.22 15.14 4 155534 29286 63304198
Asthenia 56.14 15.14 635 154903 382969 62950515
Liver function test abnormal 55.83 15.14 24 155514 48157 63285327
Peripheral swelling 55.63 15.14 938 154600 265004 63068480
Blood pressure fluctuation 55.41 15.14 22 155516 46295 63287189
Acute respiratory failure 55.35 15.14 9 155529 34476 63299008
Rash maculo-papular 54.27 15.14 7 155531 31889 63301595
Nail psoriasis 54.24 15.14 28 155510 613 63332871
Oral candidiasis 54.07 15.14 150 155388 22648 63310836
Product distribution issue 54.05 15.14 37 155501 1379 63332105
Chronic kidney disease 53.59 15.14 22 155516 45376 63288108
Melaena 53.30 15.14 6 155532 30359 63303125
Genital candidiasis 53.26 15.14 19 155519 158 63333326
Urticaria 52.86 15.14 630 154908 165172 63168312
Pericardial effusion 52.61 15.14 6 155532 30052 63303432
Disorientation 51.90 15.14 16 155522 39436 63294048
Myocardial infarction 51.79 15.14 104 155434 99789 63233695
Full blood count decreased 51.60 15.14 3 155535 26021 63307463
Axial spondyloarthritis 51.46 15.14 23 155515 361 63333123
General physical health deterioration 50.72 15.14 733 154805 200669 63132815
Lymphocyte count decreased 50.62 15.14 7 155531 30250 63303234
Cutaneous T-cell lymphoma 50.19 15.14 35 155503 1345 63332139
Skin burning sensation 50.05 15.14 102 155436 12632 63320852
Presyncope 50.03 15.14 5 155533 27780 63305704
Haematocrit decreased 49.90 15.14 17 155521 39323 63294161
Lower respiratory tract infection viral 49.88 15.14 30 155508 891 63332593
Lower respiratory tract infection 49.58 15.14 519 155019 131788 63201696
Lupus vulgaris 49.39 15.14 67 155471 5927 63327557
Hepatic cirrhosis 49.34 15.14 153 155385 24581 63308903
Alanine aminotransferase abnormal 49.29 15.14 58 155480 4446 63329038
Hepatotoxicity 48.76 15.14 15 155523 37026 63296458
Nail disorder 48.51 15.14 102 155436 12913 63320571
Urinary retention 48.43 15.14 8 155530 30293 63303191
Hypophagia 48.32 15.14 9 155529 31250 63302234
Respiratory tract congestion 48.03 15.14 123 155415 17709 63315775
Obesity 47.93 15.14 172 155366 29780 63303704
Hypermobility syndrome 47.69 15.14 28 155510 795 63332689
Disturbance in attention 47.59 15.14 17 155521 38172 63295312
Spondylitis 47.53 15.14 56 155482 4298 63329186
Seborrhoeic keratosis 47.35 15.14 42 155496 2300 63331184
Blood alkaline phosphatase increased 47.30 15.14 23 155515 42944 63290540
Hypomagnesaemia 47.26 15.14 7 155531 28730 63304754
C-reactive protein 47.13 15.14 59 155479 4823 63328661
Toxic epidermal necrolysis 47.11 15.14 4 155534 25330 63308154
Altered state of consciousness 46.87 15.14 4 155534 25226 63308258
Device leakage 46.30 15.14 71 155467 7025 63326459
Sacroiliitis 46.11 15.14 48 155490 3209 63330275
Dry skin 46.01 15.14 267 155271 56620 63276864
Hidradenitis 45.89 15.14 45 155493 2801 63330683
Sciatica 45.78 15.14 186 155352 34138 63299346
Spondyloarthropathy 45.75 15.14 28 155510 859 63332625
Off label use 45.70 15.14 1281 154257 673181 62660303
Oedema peripheral 45.37 15.14 275 155263 189236 63144248
Psychotic disorder 45.33 15.14 5 155533 25707 63307777
Limb discomfort 45.32 15.14 168 155370 29548 63303936
Device dislocation 45.32 15.14 5 155533 25700 63307784
Fluid retention 44.78 15.14 48 155490 59638 63273846
Blood calcium decreased 44.54 15.14 6 155532 26445 63307039
Hepatocellular injury 44.27 15.14 7 155531 27374 63306110
Premature delivery 44.16 15.14 10 155528 30271 63303213
Vision blurred 44.07 15.14 100 155438 91824 63241660
Pancreatitis acute 43.80 15.14 7 155531 27159 63306325
Pneumonia aspiration 43.68 15.14 15 155523 34525 63298959
Stevens-Johnson syndrome 43.62 15.14 5 155533 24945 63308539
Vulvovaginal candidiasis 43.54 15.14 46 155492 3129 63330355
Flushing 43.52 15.14 73 155465 75014 63258470
Adjustment disorder 43.50 15.14 46 155492 3132 63330352
Transient ischaemic attack 43.44 15.14 19 155519 37734 63295750
Folliculitis 43.29 15.14 308 155230 70009 63263475
Myalgia 43.25 15.14 198 155340 146331 63187153
Blood pressure increased 43.21 15.14 227 155311 161835 63171649
Movement disorder 43.21 15.14 134 155404 21527 63311957
Ascites 43.05 15.14 23 155515 40705 63292779
Breast cancer stage III 42.98 15.14 85 155453 10301 63323183
Shock 42.83 15.14 4 155534 23459 63310025
Urinary incontinence 42.08 15.14 13 155525 32001 63301483
Device delivery system issue 41.52 15.14 25 155513 744 63332740
Neck pain 41.16 15.14 301 155237 69017 63264467
Blood glucose increased 41.06 15.14 90 155448 83666 63249818
Acute myocardial infarction 40.54 15.14 14 155524 32110 63301374
Pneumonitis 40.09 15.14 18 155520 35204 63298280
Blood urea increased 39.92 15.14 8 155530 26371 63307113
Intestinal obstruction 39.81 15.14 13 155525 30886 63302598
Sinus tachycardia 39.70 15.14 6 155532 24262 63309222
Hypothyroidism 39.60 15.14 28 155510 42604 63290880
Aspartate aminotransferase increased 39.50 15.14 103 155435 90174 63243310
Cerebral haemorrhage 39.46 15.14 13 155525 30716 63302768
Premature baby 39.32 15.14 3 155535 20732 63312752
Scab 38.95 15.14 69 155469 7694 63325790
Eosinophilia 38.70 15.14 5 155533 22751 63310733
Injection site erythema 38.65 15.14 92 155446 83082 63250402
Atelectasis 38.33 15.14 4 155534 21479 63312005
Therapeutic product ineffective 38.28 15.14 33 155505 1739 63331745
Arrhythmia 38.21 15.14 23 155515 38117 63295367
Tenderness 38.15 15.14 132 155406 22446 63311038
Aggression 38.01 15.14 6 155532 23492 63309992
Dysgeusia 37.99 15.14 35 155503 46675 63286809
Spinal pain 37.87 15.14 93 155445 13046 63320438
Withdrawal syndrome 37.62 15.14 3 155535 19994 63313490
Ventricular tachycardia 37.58 15.14 3 155535 19976 63313508
Tubulointerstitial nephritis 37.40 15.14 3 155535 19900 63313584
Pain in jaw 37.30 15.14 31 155507 43465 63290019
Stress 37.25 15.14 287 155251 66880 63266604
Cytomegalovirus infection 37.13 15.14 4 155534 20948 63312536
Haematemesis 37.11 15.14 14 155524 30398 63303086
Gastrooesophageal reflux disease 36.80 15.14 116 155422 95523 63237961
Jaundice 36.48 15.14 13 155525 29238 63304246
Hepatic enzyme increased 36.39 15.14 697 154841 201631 63131853
Product dispensing error 36.38 15.14 79 155459 10226 63323258
Haematoma 36.31 15.14 20 155518 34800 63298684
Spinal fusion surgery 36.28 15.14 56 155482 5572 63327912
Wheezing 36.27 15.14 376 155162 95219 63238265
Lower limb fracture 36.16 15.14 136 155402 24085 63309399
Adverse event 35.99 15.14 286 155252 67273 63266211
Acute respiratory distress syndrome 35.90 15.14 7 155531 23527 63309957
Sneezing 35.69 15.14 112 155426 18106 63315378
Blood sodium decreased 35.38 15.14 8 155530 24244 63309240
Blood lactate dehydrogenase increased 35.00 15.14 7 155531 23109 63310375
Condition aggravated 34.89 15.14 1258 154280 400959 62932525
Secretion discharge 34.65 15.14 86 155452 12145 63321339
SARS-CoV-2 test positive 34.63 15.14 67 155471 7989 63325495
Femur fracture 34.30 15.14 31 155507 41725 63291759
Transaminases increased 34.21 15.14 17 155521 31350 63302134
Metastases to liver 34.08 15.14 8 155530 23631 63309853
Mitral valve incompetence 34.07 15.14 4 155534 19590 63313894
Coagulopathy 33.79 15.14 5 155533 20539 63312945
Symptom recurrence 33.72 15.14 31 155507 1779 63331705
Intentional product use issue 33.59 15.14 469 155069 127423 63206061
Device related infection 33.56 15.14 8 155530 23384 63310100
Dysstasia 33.40 15.14 121 155417 21045 63312439
Respiratory distress 33.28 15.14 21 155517 33930 63299554
Fungal infection 33.09 15.14 178 155360 36696 63296788
Electrolyte imbalance 32.76 15.14 5 155533 20071 63313413
Cerebral infarction 32.69 15.14 9 155529 23884 63309600
Tinnitus 32.31 15.14 24 155514 35604 63297880
Personality disorder 32.23 15.14 54 155484 5757 63327727
Device dispensing error 32.05 15.14 12 155526 116 63333368
Exposure via partner 32.05 15.14 12 155526 116 63333368
Confusional state 31.94 15.14 398 155140 235982 63097502
Muscle twitching 31.86 15.14 5 155533 19663 63313821
Coronary artery disease 31.78 15.14 20 155518 32357 63301127
Dermatitis psoriasiform 31.46 15.14 33 155505 2226 63331258
Abnormal behaviour 31.39 15.14 7 155531 21419 63312065
Alanine aminotransferase increased 31.35 15.14 139 155399 103631 63229853
Oral lichen planus 31.21 15.14 20 155518 666 63332818
Irritable bowel syndrome 31.19 15.14 324 155214 82088 63251396
Gamma-glutamyltransferase increased 30.76 15.14 23 155515 34008 63299476
Rash pustular 30.62 15.14 60 155478 7222 63326262
Psoriasis area severity index increased 30.55 15.14 10 155528 62 63333422
Hyperhidrosis 30.47 15.14 148 155390 107688 63225796
Heart rate increased 30.46 15.14 123 155415 94115 63239369
Cardiogenic shock 30.35 15.14 4 155534 17928 63315556
Hypoaesthesia 30.24 15.14 580 154958 167813 63165671
Myelodysplastic syndrome 30.20 15.14 3 155535 16751 63316733
Chronic obstructive pulmonary disease 30.20 15.14 68 155470 62618 63270866
Macular degeneration 30.12 15.14 11 155527 24365 63309119
Blood creatinine increased 30.09 15.14 112 155426 87732 63245752
Infected dermal cyst 30.02 15.14 17 155521 450 63333034
Hepatic failure 29.86 15.14 26 155512 35630 63297854
Foot deformity 29.59 15.14 141 155397 27712 63305772
Rash 29.50 15.14 1667 153871 559204 62774280
Cystitis 29.40 15.14 233 155305 54758 63278726
HLA-B*27 positive 29.26 15.14 13 155525 201 63333283
Product dose omission issue 29.14 15.14 766 154772 233547 63099937
Acute hepatic failure 28.93 15.14 5 155533 18322 63315162
Bronchiectasis 28.81 15.14 3 155535 16139 63317345
Circulatory collapse 28.67 15.14 9 155529 21929 63311555
Oedema 28.52 15.14 365 155173 97257 63236227
Product substitution issue 28.48 15.14 3 155535 15993 63317491
Parakeratosis 28.22 15.14 14 155524 281 63333203
Myoclonus 28.19 15.14 3 155535 15865 63317619
Tooth disorder 28.18 15.14 17 155521 28140 63305344
Hospitalisation 28.16 15.14 110 155428 84971 63248513
Pancreatitis 28.14 15.14 48 155490 49007 63284477
Onychomadesis 28.14 15.14 51 155487 5789 63327695
Rectal haemorrhage 28.10 15.14 48 155490 48982 63284502
Obstructive airways disorder 27.94 15.14 8 155530 20691 63312793
Heart rate irregular 27.90 15.14 10 155528 22411 63311073
Tongue disorder 27.49 15.14 72 155466 10508 63322976
Cardiomyopathy 27.32 15.14 5 155533 17579 63315905
Drug resistance 27.25 15.14 11 155527 22922 63310562
Drug ineffective for unapproved indication 27.14 15.14 26 155512 34037 63299447
Unevaluable event 27.05 15.14 53 155485 51333 63282151
Lip ulceration 26.87 15.14 29 155509 2021 63331463
Metastases to bone 26.80 15.14 9 155529 21010 63312474
Transfusion 26.72 15.14 3 155535 15214 63318270
Ataxia 26.67 15.14 3 155535 15192 63318292
Liver function test increased 26.53 15.14 154 155384 32657 63300827
Underdose 26.33 15.14 135 155403 27321 63306163
Scratch 26.29 15.14 53 155485 6512 63326972
X-ray abnormal 26.19 15.14 60 155478 8050 63325434
Complication associated with device 26.01 15.14 5 155533 16973 63316511
Cyanosis 25.91 15.14 5 155533 16930 63316554
Laboratory test abnormal 25.90 15.14 17 155521 26895 63306589
Walking aid user 25.89 15.14 71 155467 10646 63322838
Gastrointestinal pain 25.88 15.14 67 155471 9709 63323775
Pneumocystis jirovecii pneumonia 25.87 15.14 5 155533 16909 63316575
Chronic disease 25.81 15.14 11 155527 153 63333331
Tendon pain 25.64 15.14 36 155502 3290 63330194
Weight increased 25.63 15.14 467 155071 260325 63073159
Bone lesion 25.39 15.14 49 155489 5832 63327652
Cardiac murmur 25.23 15.14 3 155535 14549 63318935
Visual acuity reduced 25.08 15.14 11 155527 21815 63311669
Haemorrhage 24.91 15.14 72 155466 60950 63272534
Lymphopenia 24.89 15.14 7 155531 18320 63315164
Granuloma 24.87 15.14 48 155490 5713 63327771
Anxiety 24.83 15.14 379 155159 217162 63116322
Proteinuria 24.76 15.14 8 155530 19137 63314347
Pyoderma gangrenosum 24.68 15.14 37 155501 3588 63329896
Erythema 24.65 15.14 584 154954 175167 63158317
Road traffic accident 24.64 15.14 164 155374 36468 63297016
Live birth 24.56 15.14 126 155412 25504 63307980
Ejection fraction decreased 24.51 15.14 12 155526 22320 63311164
Rhesus antigen positive 24.49 15.14 10 155528 124 63333360
Injection site pain 24.30 15.14 450 155088 129350 63204134
Osteonecrosis 24.28 15.14 15 155523 24515 63308969
Palmoplantar pustulosis 23.45 15.14 15 155523 498 63332986
Cardiomegaly 23.42 15.14 7 155531 17607 63315877
Ileus 23.28 15.14 4 155534 14721 63318763
Respiratory rate increased 23.21 15.14 3 155535 13645 63319839
Retching 23.11 15.14 4 155534 14641 63318843
Hyperadrenocorticism 23.10 15.14 13 155525 340 63333144
Chest discomfort 23.06 15.14 166 155372 109803 63223681
Tricuspid valve incompetence 23.05 15.14 4 155534 14617 63318867
Hepatitis 22.76 15.14 39 155499 39749 63293735
Lung infiltration 22.71 15.14 4 155534 14459 63319025
Weight decreased 22.62 15.14 511 155027 276287 63057197
Seborrhoeic dermatitis 22.46 15.14 20 155518 1101 63332383
Palpitations 22.33 15.14 173 155365 112597 63220887
Kidney infection 22.25 15.14 114 155424 23062 63310422
Lichen planus 22.16 15.14 28 155510 2310 63331174
Colitis ulcerative 22.10 15.14 124 155414 25967 63307517
Urticarial vasculitis 21.88 15.14 16 155522 663 63332821
Erysipelas 21.78 15.14 55 155483 7850 63325634
Skin swelling 21.71 15.14 34 155504 3425 63330059
Nasal crusting 21.67 15.14 12 155526 304 63333180
Leukocytosis 21.61 15.14 19 155519 25916 63307568
Drug dependence 21.55 15.14 17 155521 24466 63309018
Iron deficiency anaemia 21.51 15.14 11 155527 19958 63313526
Anosmia 21.32 15.14 50 155488 6810 63326674
Pyrexia 21.29 15.14 939 154599 469539 62863945
Bacteraemia 21.14 15.14 8 155530 17340 63316144
Induration 21.13 15.14 21 155517 1329 63332155
Papulopustular rosacea 21.11 15.14 6 155532 21 63333463
Dizziness 20.93 15.14 851 154687 429074 62904410
Polyneuropathy 20.91 15.14 5 155533 14584 63318900
Blood parathyroid hormone decreased 20.87 15.14 62 155476 9729 63323755
Hemiplegia 20.80 15.14 60 155478 9263 63324221
Eczema 20.78 15.14 143 155395 32148 63301336
Upper respiratory tract infection 20.77 15.14 299 155239 81748 63251736
Peritonitis 20.76 15.14 8 155530 17146 63316338
Premature labour 20.67 15.14 3 155535 12501 63320983
Genital cyst 20.66 15.14 7 155531 49 63333435
Oral lichenoid reaction 20.53 15.14 8 155530 87 63333397
Panniculitis 20.50 15.14 68 155470 11317 63322167
Blood glucose decreased 20.48 15.14 13 155525 20939 63312545
Mania 20.36 15.14 3 155535 12364 63321120
Subdural haematoma 20.36 15.14 5 155533 14323 63319161
Candida infection 20.33 15.14 129 155409 28222 63305262
Hiatus hernia 20.30 15.14 14 155524 21580 63311904
Injection site warmth 20.28 15.14 6 155532 15189 63318295
Gait disturbance 20.27 15.14 590 154948 182588 63150896
Urosepsis 20.26 15.14 10 155528 18514 63314970
Diplopia 20.23 15.14 17 155521 23711 63309773
Renal disorder 20.10 15.14 31 155507 32943 63300541
Blood magnesium decreased 19.98 15.14 4 155534 13194 63320290
Vulval cancer stage III 19.95 15.14 5 155533 9 63333475
Collagen-vascular disease 19.83 15.14 8 155530 96 63333388
Tinea pedis 19.80 15.14 21 155517 1435 63332049
Meningitis streptococcal 19.76 15.14 9 155529 148 63333336
Skin laceration 19.70 15.14 16 155522 22692 63310792
Blood pressure diastolic decreased 19.69 15.14 16 155522 22690 63310794
Hip fracture 19.66 15.14 26 155512 29448 63304036
Impetigo 19.35 15.14 20 155518 1326 63332158
Hyperlipidaemia 19.33 15.14 12 155526 19559 63313925
Injection site laceration 19.33 15.14 8 155530 103 63333381
Dementia 19.30 15.14 11 155527 18783 63314701
Cholelithiasis 19.30 15.14 50 155488 43875 63289609
Renal tubular necrosis 19.29 15.14 3 155535 11875 63321609
Pharyngitis 19.28 15.14 99 155439 20044 63313440
Skin irritation 19.19 15.14 60 155478 9681 63323803
Product label confusion 19.17 15.14 23 155515 1799 63331685
Abscess sweat gland 18.98 15.14 5 155533 12 63333472
Hepatic cytolysis 18.95 15.14 7 155531 15400 63318084
Lethargy 18.79 15.14 72 155466 55935 63277549
Pelvic fracture 18.31 15.14 5 155533 13343 63320141
Sensory loss 18.30 15.14 61 155477 10177 63323307
Skin discomfort 18.30 15.14 14 155524 622 63332862
Loose body in joint 18.29 15.14 19 155519 1267 63332217
Motor dysfunction 18.25 15.14 63 155475 10698 63322786
Irritability 18.19 15.14 31 155507 31663 63301821
Erythematotelangiectatic rosacea 18.18 15.14 5 155533 15 63333469
Muscle spasms 18.16 15.14 271 155267 155879 63177605
Bronchospasm 17.91 15.14 10 155528 17270 63316214
Pseudomonas infection 17.83 15.14 3 155535 11210 63322274
Metastases to central nervous system 17.81 15.14 5 155533 13100 63320384
Peripheral coldness 17.77 15.14 4 155534 12161 63321323
Ischaemic stroke 17.75 15.14 11 155527 17946 63315538
Joint ankylosis 17.73 15.14 17 155521 1029 63332455
Petechiae 17.63 15.14 6 155532 13891 63319593
Abdominal distension 17.55 15.14 132 155406 86483 63247001
Tooth abscess 17.54 15.14 78 155460 14891 63318593
Multiple-drug resistance 17.53 15.14 39 155499 5131 63328353
Toxic skin eruption 17.36 15.14 5 155533 12880 63320604
Ear injury 17.35 15.14 9 155529 199 63333285
Manufacturing product shipping issue 17.35 15.14 7 155531 84 63333400
Near death experience 17.35 15.14 12 155526 455 63333029
Nightmare 17.31 15.14 13 155525 19181 63314303
Myocardial ischaemia 17.30 15.14 5 155533 12854 63320630
Metastases to lung 17.08 15.14 5 155533 12745 63320739
Drug-device interaction 16.99 15.14 7 155531 89 63333395
Impaired work ability 16.87 15.14 11 155527 17464 63316020
Oropharyngeal candidiasis 16.87 15.14 17 155521 1094 63332390
Product leakage 16.84 15.14 15 155523 826 63332658
Groin infection 16.81 15.14 11 155527 380 63333104
Diabetes mellitus inadequate control 16.80 15.14 8 155530 15118 63318366
Musculoskeletal deformity 16.74 15.14 22 155516 1887 63331597
Cellulitis 16.70 15.14 288 155250 81670 63251814
Anuria 16.67 15.14 5 155533 12546 63320938
Vaginal haemorrhage 16.60 15.14 26 155512 27461 63306023
Cytopenia 16.58 15.14 4 155534 11597 63321887
Haemophagocytic lymphohistiocytosis 16.55 15.14 3 155535 10624 63322860
Neutrophil count increased 16.51 15.14 10 155528 16517 63316967
Decubitus ulcer 16.32 15.14 3 155535 10517 63322967
Diarrhoea haemorrhagic 16.27 15.14 54 155484 8988 63324496
Food allergy 16.16 15.14 4 155534 11397 63322087
Affect lability 16.14 15.14 62 155476 11089 63322395
Dialysis 16.12 15.14 3 155535 10424 63323060
Creatinine renal clearance decreased 16.10 15.14 10 155528 16298 63317186
Pregnancy on contraceptive 15.87 15.14 17 155521 1175 63332309
Small intestinal obstruction 15.81 15.14 13 155525 18324 63315160
Ear infection fungal 15.75 15.14 8 155530 169 63333315
Hypertensive crisis 15.62 15.14 9 155529 15277 63318207
Dandruff 15.60 15.14 9 155529 247 63333237
Poisoning 15.59 15.14 7 155531 13693 63319791
Fracture 15.54 15.14 15 155523 19569 63313915
Head injury 15.54 15.14 27 155511 27369 63306115
Actinic keratosis 15.53 15.14 25 155513 2579 63330905
Ecchymosis 15.52 15.14 4 155534 11090 63322394
Gallbladder rupture 15.47 15.14 11 155527 436 63333048
Benign laryngeal neoplasm 15.42 15.14 5 155533 30 63333454
Red cell distribution width decreased 15.40 15.14 22 155516 2043 63331441
White blood cell count increased 15.30 15.14 64 155474 48497 63284987
Cerebrovascular accident 15.29 15.14 180 155358 107844 63225640

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1622.81 15.01 2846 57746 453905 34442434
Inappropriate schedule of product administration 1134.42 15.01 906 59686 61390 34834949
Psoriasis 1088.62 15.01 733 59859 38079 34858260
Incorrect dose administered 860.50 15.01 646 59946 39869 34856470
Arthralgia 753.94 15.01 1177 59415 168864 34727475
Device malfunction 739.23 15.01 361 60231 10060 34886279
Psoriatic arthropathy 680.08 15.01 425 60167 19373 34876966
Skin plaque 601.88 15.01 245 60347 4369 34891970
Therapeutic product effect incomplete 596.46 15.01 575 60017 49966 34846373
Pain 548.29 15.01 1138 59454 203537 34692802
Musculoskeletal stiffness 469.40 15.01 487 60105 46193 34850146
Pruritus 447.72 15.01 846 59746 141135 34755204
Device issue 368.99 15.01 223 60369 9554 34886785
Nasopharyngitis 368.39 15.01 526 60066 69442 34826897
Arthritis 368.29 15.01 356 60236 30990 34865349
Accidental exposure to product 366.00 15.01 245 60347 12557 34883782
Skin exfoliation 361.42 15.01 332 60260 27100 34869239
Incorrect dose administered by device 346.71 15.01 128 60464 1730 34894609
Acute kidney injury 344.31 15.01 58 60534 304930 34591409
Toxicity to various agents 326.42 15.01 4 60588 200358 34695981
Joint swelling 316.29 15.01 451 60141 59439 34836900
Skin lesion 244.02 15.01 242 60350 21719 34874620
Macule 241.32 15.01 93 60499 1424 34894915
Drug interaction 239.69 15.01 50 60542 225896 34670443
Treatment failure 229.47 15.01 340 60252 46357 34849982
Febrile neutropenia 221.55 15.01 3 60589 136846 34759493
Anaemia 214.36 15.01 69 60523 233266 34663073
Uveitis 210.04 15.01 142 60450 7393 34888946
Hypotension 195.83 15.01 70 60522 221579 34674760
Therapeutic product effect decreased 191.20 15.01 267 60325 34476 34861863
Pain in extremity 190.02 15.01 565 60027 125948 34770391
Product dose omission issue 182.02 15.01 537 60055 119174 34777165
Neutropenia 171.77 15.01 32 60560 156746 34739593
Ankylosing spondylitis 171.64 15.01 112 60480 5492 34890847
Inflammation 167.06 15.01 225 60367 28070 34868269
Neck pain 165.82 15.01 212 60380 25137 34871202
Thrombocytopenia 164.67 15.01 35 60557 156212 34740127
Decreased immune responsiveness 152.98 15.01 69 60523 1595 34894744
Therapy interrupted 143.06 15.01 146 60446 13551 34882788
Device defective 140.07 15.01 52 60540 714 34895625
Erythema 139.38 15.01 403 60189 88377 34807962
Erysipelas 138.77 15.01 93 60499 4770 34891569
Injection site haemorrhage 137.94 15.01 123 60469 9645 34886694
Completed suicide 137.92 15.01 8 60584 98160 34798179
Inflammatory bowel disease 137.71 15.01 77 60515 2843 34893496
Influenza 136.64 15.01 280 60312 49386 34846953
Therapeutic response shortened 132.83 15.01 107 60485 7297 34889042
Product storage error 132.36 15.01 111 60481 8011 34888328
Product prescribing error 124.32 15.01 175 60417 22752 34873587
Malaise 121.68 15.01 639 59953 185186 34711153
Spinal pain 120.54 15.01 92 60500 5797 34890542
COVID-19 115.92 15.01 346 60246 77204 34819135
Needle issue 114.65 15.01 91 60501 6074 34890265
Back pain 113.85 15.01 465 60127 121324 34775015
Respiratory failure 112.95 15.01 25 60567 108547 34787792
Oropharyngeal pain 110.79 15.01 211 60381 35274 34861065
Disease progression 110.20 15.01 26 60566 108051 34788288
Off label use 109.61 15.01 368 60224 419156 34477183
Sinusitis 108.69 15.01 229 60363 41173 34855166
Confusional state 106.02 15.01 59 60533 144101 34752238
Wrong technique in device usage process 106.01 15.01 52 60540 1460 34894879
Pancytopenia 105.05 15.01 19 60573 95138 34801201
Cellulitis 103.79 15.01 261 60331 52690 34843649
Platelet count decreased 101.89 15.01 40 60552 119677 34776662
Peripheral swelling 101.87 15.01 328 60264 76213 34820126
Dactylitis 100.18 15.01 43 60549 879 34895460
Pain of skin 98.53 15.01 83 60509 6026 34890313
Arthropathy 97.94 15.01 171 60421 26736 34869603
Injection site pain 96.92 15.01 211 60381 38794 34857545
Decreased appetite 96.28 15.01 88 60504 166304 34730035
Rhabdomyolysis 94.37 15.01 6 60586 68157 34828182
Constipation 93.79 15.01 61 60531 136921 34759418
Papule 89.90 15.01 67 60525 4072 34892267
Illness 89.79 15.01 114 60478 13415 34882924
Death 88.38 15.01 373 60219 397676 34498663
Hyponatraemia 88.12 15.01 18 60574 82673 34813666
Haemoglobin decreased 86.53 15.01 51 60541 120721 34775618
Vein rupture 84.34 15.01 38 60554 876 34895463
Therapy cessation 83.88 15.01 124 60468 16849 34879490
Hyperkalaemia 83.06 15.01 11 60581 69378 34826961
Lower respiratory tract infection 83.03 15.01 175 60417 31462 34864877
Scab 82.93 15.01 67 60525 4587 34891752
Seizure 81.37 15.01 40 60552 104817 34791522
Bradycardia 81.23 15.01 16 60576 75402 34820937
Dehydration 80.95 15.01 64 60528 129905 34766434
Sacroiliitis 80.31 15.01 43 60549 1455 34894884
Overdose 79.84 15.01 29 60563 91030 34805309
Skin fissures 79.81 15.01 69 60523 5190 34891149
Joint stiffness 79.19 15.01 96 60496 10777 34885562
Infection 78.54 15.01 339 60253 90576 34805763
C-reactive protein increased 77.62 15.01 238 60354 53860 34842479
Cardiac arrest 77.19 15.01 35 60557 96124 34800215
Localised infection 76.36 15.01 121 60471 17466 34878873
Cardio-respiratory arrest 76.11 15.01 5 60587 55268 34841071
Incorrect route of product administration 75.60 15.01 110 60482 14735 34881604
Skin haemorrhage 74.30 15.01 63 60529 4615 34891724
Renal failure 73.20 15.01 71 60521 130486 34765853
White blood cell count decreased 71.67 15.01 38 60554 95407 34800932
Drug intolerance 70.12 15.01 245 60347 59325 34837014
Acne 69.91 15.01 91 60501 10975 34885364
Vomiting 69.49 15.01 210 60382 247411 34648928
Neutrophil count decreased 69.27 15.01 5 60587 51099 34845240
International normalised ratio increased 69.16 15.01 3 60589 47324 34849015
Enthesopathy 68.94 15.01 60 60532 4553 34891786
Dry skin 68.52 15.01 161 60431 31126 34865213
Oral candidiasis 67.96 15.01 94 60498 12016 34884323
Multiple organ dysfunction syndrome 67.77 15.01 24 60568 76542 34819797
Concomitant disease aggravated 67.35 15.01 65 60527 5636 34890703
Gastrointestinal haemorrhage 66.77 15.01 35 60557 88442 34807897
Nail psoriasis 66.66 15.01 18 60574 77 34896262
Synovitis 65.57 15.01 100 60492 13966 34882373
Sepsis 65.37 15.01 118 60474 166443 34729896
Joint ankylosis 64.87 15.01 38 60554 1534 34894805
Intentional product use issue 63.76 15.01 13 60579 59803 34836536
Venous injury 63.66 15.01 23 60569 291 34896048
Scratch 63.50 15.01 50 60542 3298 34893041
Therapeutic product effect delayed 63.32 15.01 35 60557 1263 34895076
Hypoxia 62.99 15.01 10 60582 55085 34841254
Septic shock 62.75 15.01 23 60569 71811 34824528
Colitis ulcerative 62.73 15.01 107 60485 16413 34879926
Product distribution issue 61.92 15.01 28 60564 651 34895688
Pleural effusion 61.91 15.01 32 60560 81514 34814825
Tachycardia 61.83 15.01 35 60557 84737 34811602
Depressed level of consciousness 61.67 15.01 3 60589 42838 34853501
Hypokalaemia 61.33 15.01 13 60579 58201 34838138
Plasma cell myeloma 60.33 15.01 3 60589 42034 34854305
Rebound psoriasis 60.02 15.01 18 60574 120 34896219
Symptom recurrence 59.16 15.01 28 60564 725 34895614
Injection site bruising 59.07 15.01 74 60518 8589 34887750
Delirium 57.67 15.01 5 60587 43986 34852353
Infusion related reaction 57.66 15.01 11 60581 53046 34843293
Intentional product misuse 57.63 15.01 6 60586 45605 34850734
Metabolic acidosis 57.17 15.01 5 60587 43675 34852664
Skin disorder 57.11 15.01 92 60500 13463 34882876
Mobility decreased 56.40 15.01 146 60446 29982 34866357
Discomfort 55.89 15.01 110 60482 18828 34877511
Epistaxis 55.55 15.01 16 60576 58235 34838104
Renal impairment 54.59 15.01 50 60542 94463 34801876
Burning sensation 54.48 15.01 107 60485 18287 34878052
Therapeutic product ineffective 54.43 15.01 27 60565 777 34895562
Dyspnoea 54.12 15.01 407 60185 376375 34519964
Hypoglycaemia 54.00 15.01 14 60578 54626 34841713
Rhinorrhoea 53.94 15.01 130 60462 25538 34870801
Ear infection 53.83 15.01 77 60515 10154 34886185
Dermatitis psoriasiform 53.54 15.01 33 60559 1463 34894876
Neuropathy peripheral 53.09 15.01 40 60552 83223 34813116
Upper respiratory tract infection 52.69 15.01 151 60441 32908 34863431
Agitation 52.51 15.01 17 60575 57382 34838957
Hallucination 51.27 15.01 13 60579 51485 34844854
Skin injury 51.01 15.01 38 60554 2307 34894032
Atrial fibrillation 50.46 15.01 84 60508 122309 34774030
Electrocardiogram QT prolonged 50.19 15.01 6 60586 40946 34855393
Suicide attempt 49.80 15.01 5 60587 39111 34857228
Swelling 49.62 15.01 174 60418 42192 34854147
Aggression 49.55 15.01 5 60587 38959 34857380
Mycobacterium tuberculosis complex test positive 49.25 15.01 30 60562 1302 34895037
Oxygen saturation decreased 49.13 15.01 16 60576 53802 34842537
Grip strength decreased 48.94 15.01 42 60550 3127 34893212
Syncope 47.54 15.01 53 60539 91398 34804941
Injection site papule 47.53 15.01 19 60573 322 34896017
Movement disorder 47.39 15.01 80 60512 12168 34884171
Blood creatine phosphokinase increased 47.28 15.01 10 60582 44847 34851492
Musculoskeletal discomfort 45.83 15.01 63 60529 8005 34888334
Fall 45.53 15.01 189 60403 202696 34693643
Asthenia 45.36 15.01 245 60347 245006 34651333
Muscle swelling 45.06 15.01 19 60573 371 34895968
Rash 44.92 15.01 586 60006 222166 34674173
Palmoplantar pustulosis 44.58 15.01 14 60578 111 34896228
Coma 44.57 15.01 12 60580 45666 34850673
Ligament calcification 44.17 15.01 16 60576 204 34896135
Latent tuberculosis 43.60 15.01 28 60564 1335 34895004
Oedema peripheral 43.38 15.01 89 60503 119723 34776616
Mental status changes 43.33 15.01 7 60585 38076 34858263
Drug reaction with eosinophilia and systemic symptoms 42.60 15.01 4 60588 33008 34863331
Pharyngitis streptococcal 42.32 15.01 36 60556 2648 34893691
Tuberculosis 41.42 15.01 62 60530 8515 34887824
Deep vein thrombosis 40.75 15.01 32 60560 65216 34831123
Pelvic pain 40.62 15.01 34 60558 2446 34893893
Pulmonary embolism 40.42 15.01 58 60534 89688 34806651
Skin infection 40.36 15.01 58 60534 7679 34888660
Skin irritation 40.21 15.01 49 60543 5528 34890811
Self-consciousness 40.02 15.01 11 60581 51 34896288
Somnolence 39.83 15.01 83 60509 111033 34785306
Loss of consciousness 39.68 15.01 51 60541 82616 34813723
Tremor 39.59 15.01 51 60541 82536 34813803
Pulmonary oedema 38.59 15.01 17 60575 47512 34848827
Lactic acidosis 38.22 15.01 7 60585 34765 34861574
Mucosal inflammation 37.96 15.01 10 60582 38612 34857727
Hepatic cirrhosis 37.79 15.01 89 60503 17225 34879114
Tenderness 37.68 15.01 53 60539 6881 34889458
Abscess limb 37.64 15.01 38 60554 3479 34892860
Respiratory distress 37.49 15.01 8 60584 35657 34860682
Blood creatinine increased 37.47 15.01 67 60525 94909 34801430
Eczema 37.27 15.01 92 60500 18344 34877995
Product dispensing error 37.17 15.01 50 60542 6224 34890115
Melaena 37.06 15.01 8 60584 35372 34860967
Cardiac failure 36.33 15.01 64 60528 91184 34805155
Cutaneous symptom 36.15 15.01 15 60577 281 34896058
Rash erythematous 35.90 15.01 110 60482 24867 34871472
Hepatic function abnormal 35.81 15.01 16 60576 44347 34851992
Oral herpes 35.63 15.01 46 60546 5501 34890838
Pneumonia aspiration 35.61 15.01 14 60578 41889 34854450
Insurance issue 35.58 15.01 29 60563 2010 34894329
Hyperglycaemia 35.57 15.01 12 60580 39468 34856871
Sensitisation 35.25 15.01 13 60579 175 34896164
Nephrolithiasis 35.01 15.01 124 60468 30209 34866130
Cough 34.98 15.01 406 60186 149734 34746605
Pneumonia 34.88 15.01 432 60160 362195 34534144
Ear infection fungal 33.62 15.01 9 60583 37 34896302
Product availability issue 33.27 15.01 27 60565 1860 34894479
Lipoma 33.21 15.01 26 60566 1700 34894639
Upper gastrointestinal haemorrhage 33.17 15.01 3 60589 25515 34870824
Encephalopathy 33.12 15.01 10 60582 35309 34861030
Spondylitis 33.04 15.01 23 60569 1255 34895084
Dyshidrotic eczema 32.92 15.01 12 60580 156 34896183
Pneumonitis 32.86 15.01 9 60583 33869 34862470
Bone cyst 32.75 15.01 25 60567 1575 34894764
Terminal insomnia 31.86 15.01 17 60575 571 34895768
Injection site swelling 31.67 15.01 65 60527 11462 34884877
Oligoarthritis 31.51 15.01 11 60581 125 34896214
Orthostatic hypotension 31.27 15.01 4 60588 25915 34870424
Hypocalcaemia 31.19 15.01 3 60589 24286 34872053
Drug dependence 31.07 15.01 3 60589 24214 34872125
Tinea versicolour 30.90 15.01 14 60578 327 34896012
Device dispensing error 30.82 15.01 9 60583 54 34896285
Medication error 30.71 15.01 4 60588 25561 34870778
Hand deformity 30.62 15.01 35 60557 3690 34892649
Cholestasis 30.55 15.01 5 60587 26943 34869396
Agranulocytosis 30.44 15.01 3 60589 23818 34872521
Secretion discharge 30.41 15.01 44 60548 5861 34890478
Onycholysis 30.12 15.01 18 60574 754 34895585
Stress 29.97 15.01 118 60474 30229 34866110
Abnormal behaviour 29.77 15.01 4 60588 24965 34871374
Cutaneous lymphoma 29.70 15.01 10 60582 101 34896238
Anti-cyclic citrullinated peptide antibody positive 29.63 15.01 25 60567 1818 34894521
Accident 29.56 15.01 40 60552 5007 34891332
Product supply issue 29.50 15.01 17 60575 665 34895674
Influenza like illness 29.38 15.01 110 60482 27524 34868815
Cytomegalovirus infection 29.30 15.01 5 60587 26130 34870209
Tooth abscess 29.26 15.01 43 60549 5810 34890529
Hidradenitis 29.22 15.01 20 60572 1062 34895277
Dermatitis exfoliative generalised 29.08 15.01 34 60558 3673 34892666
Skin burning sensation 29.04 15.01 38 60554 4605 34891734
Musculoskeletal pain 28.96 15.01 121 60471 31842 34864497
Hypersensitivity 28.89 15.01 193 60399 60842 34835497
Aspartate aminotransferase increased 28.40 15.01 46 60546 67737 34828602
Disorientation 28.35 15.01 11 60581 33177 34863162
Therapeutic response decreased 28.16 15.01 113 60479 29200 34867139
Folliculitis 27.98 15.01 37 60555 4529 34891810
Blood pressure fluctuation 27.93 15.01 5 60587 25244 34871095
Irritable bowel syndrome 27.89 15.01 33 60559 3610 34892729
Urinary retention 27.88 15.01 14 60578 36274 34860065
Ascites 27.64 15.01 24 60568 46547 34849792
Haematemesis 27.57 15.01 7 60585 27704 34868635
Hepatic steatosis 27.45 15.01 82 60510 18280 34878059
Candida infection 27.33 15.01 80 60512 17635 34878704
Angiocardiogram 27.27 15.01 11 60581 191 34896148
Nasal congestion 27.25 15.01 95 60497 22962 34873377
Body surface area increased 27.18 15.01 9 60583 86 34896253
Respiratory tract infection 26.66 15.01 85 60507 19627 34876712
Red blood cell sedimentation rate abnormal 26.64 15.01 32 60560 3557 34892782
Skin discomfort 26.57 15.01 10 60582 143 34896196
Altered state of consciousness 26.51 15.01 4 60588 22889 34873450
Malignant melanoma 26.34 15.01 49 60543 8041 34888298
Seborrhoeic keratosis 26.32 15.01 20 60572 1251 34895088
Exposure to communicable disease 26.31 15.01 10 60582 147 34896192
Shock 26.29 15.01 5 60587 24174 34872165
Blood bilirubin increased 26.24 15.01 17 60575 38279 34858060
Restlessness 26.20 15.01 6 60586 25476 34870863
Cerebral haemorrhage 26.07 15.01 14 60578 34923 34861416
Dyspnoea exertional 26.05 15.01 22 60570 43257 34853082
Inflammatory pain 26.03 15.01 11 60581 216 34896123
Tonsillitis bacterial 25.91 15.01 7 60585 30 34896309
Ventricular tachycardia 25.89 15.01 7 60585 26572 34869767
Feeling abnormal 25.86 15.01 193 60399 63042 34833297
Pustular psoriasis 25.81 15.01 22 60570 1623 34894716
Wound 25.75 15.01 70 60522 14794 34881545
Iridocyclitis 25.73 15.01 22 60570 1630 34894709
Red blood cell sedimentation rate increased 25.57 15.01 52 60540 9110 34887229
Dermatitis 25.56 15.01 53 60539 9415 34886924
Device leakage 25.50 15.01 43 60549 6532 34889807
Hypokinesia 25.50 15.01 51 60541 8829 34887510
Hepatocellular injury 25.45 15.01 4 60588 22207 34874132
Limb discomfort 25.44 15.01 58 60534 10989 34885350
Xyphoid retraction 25.37 15.01 10 60582 163 34896176
Tinea pedis 25.36 15.01 21 60571 1488 34894851
Disability 25.26 15.01 36 60556 4729 34891610
Injection site reaction 25.25 15.01 64 60528 12969 34883370
Skin discolouration 25.10 15.01 78 60514 17767 34878572
Basal cell carcinoma 24.99 15.01 83 60509 19575 34876764
Genital candidiasis 24.88 15.01 8 60584 69 34896270
Psoriasis area severity index increased 24.87 15.01 7 60585 36 34896303
Psychotic disorder 24.66 15.01 6 60586 24446 34871893
Tooth infection 24.58 15.01 43 60549 6728 34889611
Eye infection 24.44 15.01 31 60561 3642 34892697
Bursitis 24.31 15.01 38 60554 5420 34890919
Dizziness 24.21 15.01 252 60340 218269 34678070
Guttate psoriasis 24.20 15.01 11 60581 259 34896080
Interstitial lung disease 24.03 15.01 48 60544 65234 34831105
Haematuria 23.90 15.01 31 60561 50035 34846304
Hypervolaemia 23.87 15.01 3 60589 19706 34876633
Tonsillitis 23.86 15.01 25 60567 2391 34893948
Tubulointerstitial nephritis 23.61 15.01 4 60588 21020 34875319
Pigmentation disorder 23.41 15.01 25 60567 2444 34893895
Tendonitis 23.32 15.01 50 60542 9090 34887249
Drug resistance 23.14 15.01 8 60584 25919 34870420
Underdose 22.98 15.01 64 60528 13716 34882623
Lentigo 22.98 15.01 13 60579 491 34895848
Seronegative arthritis 22.97 15.01 17 60575 1022 34895317
Alanine aminotransferase abnormal 22.80 15.01 34 60558 4654 34891685
Oesophageal infection 22.78 15.01 11 60581 298 34896041
Total cholesterol/HDL ratio decreased 22.69 15.01 7 60585 52 34896287
Subdural haematoma 22.68 15.01 4 60588 20417 34875922
Nail pitting 22.58 15.01 11 60581 304 34896035
Intestinal haemorrhage 22.47 15.01 29 60563 3467 34892872
Abdominal discomfort 22.45 15.01 179 60413 59656 34836683
Body mass index abnormal 22.43 15.01 9 60583 154 34896185
Haemorrhage 22.33 15.01 34 60558 51336 34845003
Acute respiratory failure 22.20 15.01 13 60579 30915 34865424
Stevens-Johnson syndrome 22.19 15.01 3 60589 18636 34877703
Coronavirus infection 22.05 15.01 32 60560 4275 34892064
Actinic keratosis 22.03 15.01 33 60559 4534 34891805
Immune system disorder 21.93 15.01 35 60557 5080 34891259
Angioimmunoblastic T-cell lymphoma 21.81 15.01 11 60581 328 34896011
Product leakage 21.70 15.01 13 60579 547 34895792
Energy increased 21.66 15.01 18 60574 1282 34895057
Hepatic failure 21.47 15.01 17 60575 34514 34861825
Bone marrow failure 21.42 15.01 12 60580 29241 34867098
Conjunctivitis viral 21.31 15.01 7 60585 65 34896274
Gastrointestinal infection 21.28 15.01 37 60555 5761 34890578
Chronic kidney disease 21.27 15.01 24 60568 41186 34855153
Bronchitis 21.26 15.01 135 60457 41828 34854511
Onychomadesis 21.16 15.01 13 60579 573 34895766
Blood alkaline phosphatase increased 21.14 15.01 14 60578 31161 34865178
Therapy non-responder 21.12 15.01 128 60464 39018 34857321
Blood potassium decreased 21.05 15.01 3 60589 17912 34878427
Spinal disorder 20.91 15.01 31 60561 4221 34892118
Cyst 20.83 15.01 32 60560 4496 34891843
Bone erosion 20.80 15.01 30 60562 3985 34892354
Atelectasis 20.75 15.01 3 60589 17724 34878615
Pseudarthrosis 20.51 15.01 7 60585 74 34896265
Hypophagia 20.45 15.01 8 60584 24014 34872325
Hepatic fibrosis 20.41 15.01 32 60560 4575 34891764
Erythrodermic psoriasis 20.41 15.01 15 60577 892 34895447
C-reactive protein abnormal 20.36 15.01 46 60546 8664 34887675
Viral infection 20.30 15.01 72 60520 17551 34878788
Acute respiratory distress syndrome 19.98 15.01 10 60582 25959 34870380
Dyskinesia 19.86 15.01 7 60585 22406 34873933
Joint injury 19.85 15.01 47 60545 9126 34887213
Generalised tonic-clonic seizure 19.84 15.01 6 60586 21168 34875171
Hepatic mass 19.60 15.01 16 60576 1111 34895228
Tachypnoea 19.52 15.01 4 60588 18348 34877991
Pulmonary hypertension 19.48 15.01 6 60586 20918 34875421
Premature baby 19.45 15.01 5 60587 19628 34876711
Acute myeloid leukaemia 19.40 15.01 4 60588 18266 34878073
Kidney infection 19.25 15.01 34 60558 5360 34890979
Gastrointestinal pain 19.13 15.01 27 60565 3515 34892824
Diabetes mellitus 19.12 15.01 143 60449 46730 34849609
Ocular hyperaemia 18.91 15.01 53 60539 11399 34884940
Fear of injection 18.91 15.01 18 60574 1534 34894805
Eosinophilia 18.86 15.01 11 60581 26211 34870128
Gait disturbance 18.81 15.01 228 60364 84912 34811427
Rosacea 18.81 15.01 16 60576 1177 34895162
Oral pustule 18.70 15.01 9 60583 242 34896097
Nausea 18.62 15.01 448 60144 339460 34556879
Balance disorder 18.56 15.01 26 60566 40628 34855711
Osteolysis 18.51 15.01 25 60567 3123 34893216
Skin ulcer 18.50 15.01 82 60510 22134 34874205
Disturbance in attention 18.49 15.01 11 60581 25934 34870405
Diarrhoea haemorrhagic 18.42 15.01 38 60554 6726 34889613
Staphylococcal skin infection 18.37 15.01 14 60578 880 34895459
Arrhythmia 18.32 15.01 21 60571 35787 34860552
General physical health deterioration 18.10 15.01 139 60453 128130 34768209
Haematoma 18.05 15.01 11 60581 25594 34870745
Ear pruritus 17.98 15.01 10 60582 365 34895974
Carbon dioxide abnormal 17.85 15.01 8 60584 182 34896157
Osteoarthritis 17.81 15.01 77 60515 20565 34875774
Leukopenia 17.78 15.01 53 60539 62803 34833536
Flushing 17.72 15.01 18 60574 32402 34863937
Rash maculo-papular 17.70 15.01 14 60578 28437 34867902
Skin papilloma 17.69 15.01 20 60572 2083 34894256
Stomatitis 17.66 15.01 29 60563 42485 34853854
Renal tubular necrosis 17.57 15.01 3 60589 15677 34880662
Blood lactate dehydrogenase increased 17.47 15.01 9 60583 22981 34873358
Spondyloarthropathy 17.43 15.01 12 60580 643 34895696
Wheezing 17.43 15.01 28 60564 41374 34854965
Coronary artery disease 17.36 15.01 36 60556 48269 34848070
Dry mouth 17.35 15.01 16 60576 30149 34866190
Obstructive airways disorder 17.29 15.01 3 60589 15491 34880848
Chronic obstructive pulmonary disease 17.13 15.01 37 60555 48881 34847458
Pneumothorax 16.85 15.01 6 60586 19086 34877253
Ear neoplasm 16.82 15.01 6 60586 73 34896266
Hospitalisation 16.81 15.01 47 60545 56855 34839484
Eye discharge 16.75 15.01 19 60573 1987 34894352
Pustule 16.73 15.01 11 60581 546 34895793
Ulcer 16.72 15.01 43 60549 8792 34887547
Undifferentiated connective tissue disease 16.71 15.01 5 60587 33 34896306
Post infection glomerulonephritis 16.60 15.01 6 60586 76 34896263
Dysgeusia 16.53 15.01 13 60579 26484 34869855
Lower respiratory tract congestion 16.43 15.01 15 60577 1212 34895127
Blood urea increased 16.43 15.01 17 60575 30347 34865992
Injection site paraesthesia 16.40 15.01 7 60585 141 34896198
Pyoderma gangrenosum 16.31 15.01 16 60576 1415 34894924
Dandruff 16.26 15.01 8 60584 226 34896113
Sinus tachycardia 16.12 15.01 5 60587 17355 34878984
Nasal abscess 16.08 15.01 3 60589 0 34896339
Administration site haemorrhage 16.08 15.01 3 60589 0 34896339
Hepatic encephalopathy 16.04 15.01 3 60589 14682 34881657
Diverticulitis 16.03 15.01 73 60519 19931 34876408
Melanocytic naevus 15.94 15.01 20 60572 2324 34894015
Bursitis infective 15.94 15.01 11 60581 592 34895747
Xerosis 15.92 15.01 11 60581 593 34895746
Cutaneous sarcoidosis 15.92 15.01 7 60585 152 34896187
Scrotal cancer 15.91 15.01 4 60588 12 34896327
Anaphylactic shock 15.91 15.01 4 60588 15937 34880402
Furuncle 15.82 15.01 24 60568 3334 34893005
Fibromyalgia 15.82 15.01 23 60569 3077 34893262
Feeling hot 15.76 15.01 71 60521 19301 34877038
Skin lesion inflammation 15.67 15.01 4 60588 13 34896326
Skin candida 15.62 15.01 10 60582 474 34895865
Coronavirus test positive 15.51 15.01 10 60582 480 34895859
Laboratory test abnormal 15.47 15.01 8 60584 20383 34875956
Cardiomyopathy 15.33 15.01 5 60587 16803 34879536
Granuloma annulare 15.28 15.01 7 60585 168 34896171
Borrelia infection 15.27 15.01 5 60587 46 34896293
Nail dystrophy 15.21 15.01 8 60584 261 34896078
Axillary pain 15.13 15.01 9 60583 374 34895965
Joint effusion 15.12 15.01 30 60562 5163 34891176
Liver function test abnormal 15.07 15.01 19 60573 31055 34865284
Adrenal insufficiency 15.07 15.01 3 60589 14044 34882295

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Inappropriate schedule of product administration 1194.32 14.91 1372 151012 132256 79459748
Psoriasis 1037.29 14.91 1055 151329 88532 79503472
Musculoskeletal stiffness 897.04 14.91 1368 151016 173640 79418364
Psoriatic arthropathy 881.86 14.91 907 151477 77092 79514912
Drug ineffective 806.48 14.91 4123 148261 1076790 78515214
Therapy interrupted 763.77 14.91 565 151819 30776 79561228
Acute kidney injury 739.71 14.91 70 152314 519334 79072670
Toxicity to various agents 732.83 14.91 15 152369 421525 79170479
Arthralgia 651.75 14.91 2480 149904 569323 79022681
Drug interaction 540.81 14.91 76 152308 415107 79176897
Nasopharyngitis 527.48 14.91 1358 151026 252523 79339481
Skin plaque 514.61 14.91 296 152088 10449 79581555
Hypotension 493.33 14.91 118 152266 440199 79151805
Pain 484.23 14.91 2630 149754 701172 78890832
Anaemia 477.93 14.91 130 152254 444885 79147119
Therapeutic product effect incomplete 442.51 14.91 891 151493 140754 79451250
Joint swelling 442.15 14.91 1383 151001 287263 79304741
Completed suicide 438.18 14.91 6 152378 245761 79346243
Incorrect dose administered 426.27 14.91 623 151761 76007 79515997
Febrile neutropenia 424.08 14.91 3 152381 230996 79361008
Neutropenia 405.82 14.91 40 152344 287670 79304334
Arthritis 386.99 14.91 746 151638 114134 79477870
Treatment failure 342.44 14.91 901 151483 169585 79422419
Thrombocytopenia 339.45 14.91 51 152333 265208 79326796
Therapeutic product effect decreased 327.06 14.91 864 151520 162999 79429005
Synovitis 317.47 14.91 811 151573 149923 79442081
Death 315.93 14.91 371 152013 566143 79025861
Skin exfoliation 304.96 14.91 447 151937 54653 79537351
Inflammation 303.74 14.91 599 151785 93154 79498850
Wound 287.21 14.91 665 151719 115514 79476490
Fibromyalgia 286.29 14.91 472 151912 63868 79528136
Liver injury 280.24 14.91 436 151948 56178 79535826
Malaise 271.30 14.91 1731 150653 488138 79103866
Discomfort 270.84 14.91 682 151702 124935 79467069
Rheumatic fever 269.76 14.91 302 152082 28223 79563781
Hyponatraemia 257.96 14.91 22 152362 177826 79414178
Skin lesion 257.36 14.91 357 152027 41487 79550517
Pruritus 252.35 14.91 1448 150936 393200 79198804
Arthropathy 252.01 14.91 828 151556 176283 79415721
Mobility decreased 251.65 14.91 652 151732 121523 79470481
Infection 248.61 14.91 1017 151367 240695 79351309
Influenza 247.04 14.91 672 151712 128934 79463070
Constipation 246.88 14.91 116 152268 282934 79309070
Malignant neoplasm progression 239.38 14.91 4 152380 135986 79456018
Enthesopathy 238.20 14.91 189 152195 11419 79580585
Swollen joint count increased 234.59 14.91 253 152131 22674 79569330
Hand deformity 234.31 14.91 574 151810 103345 79488659
Pemphigus 231.96 14.91 557 151827 99025 79492979
Drug intolerance 231.55 14.91 1059 151325 263060 79328944
Platelet count decreased 230.18 14.91 46 152338 194618 79397386
COVID-19 229.57 14.91 743 151641 156931 79435073
Glossodynia 228.98 14.91 567 151817 102770 79489234
Type 2 diabetes mellitus 228.91 14.91 400 151984 56722 79535282
Respiratory failure 226.33 14.91 37 152347 180874 79411130
Pain in extremity 222.24 14.91 1321 151063 363217 79228787
Disease progression 217.08 14.91 44 152340 184318 79407686
Pancytopenia 216.29 14.91 30 152354 165715 79426289
Systemic lupus erythematosus 209.11 14.91 606 151778 120543 79471461
Oropharyngeal pain 207.37 14.91 566 151818 108787 79483217
Bradycardia 204.38 14.91 14 152370 135543 79456461
Haemoglobin decreased 203.14 14.91 85 152299 222034 79369970
Anti-cyclic citrullinated peptide antibody positive 202.23 14.91 473 151911 82670 79509334
Pericarditis 202.14 14.91 544 151840 103692 79488312
Cardiac arrest 200.70 14.91 42 152342 172054 79419950
Device malfunction 195.85 14.91 223 152161 21225 79570779
Rheumatoid factor positive 190.93 14.91 380 152004 59459 79532545
Hypokalaemia 190.48 14.91 25 152359 144015 79447989
C-reactive protein increased 190.48 14.91 611 151773 128416 79463588
White blood cell count decreased 187.32 14.91 63 152321 188225 79403779
Dehydration 187.03 14.91 122 152262 248065 79343939
Illness 184.15 14.91 324 152060 46187 79545817
Abdominal discomfort 182.21 14.91 953 151431 249774 79342230
Grip strength decreased 180.70 14.91 216 152168 21653 79570351
Rheumatoid arthritis 178.98 14.91 831 151553 207639 79384365
Seronegative arthritis 177.29 14.91 111 152273 4581 79587423
Renal failure 177.28 14.91 81 152303 200887 79391117
Ear infection 177.14 14.91 270 152114 34162 79557842
Skin haemorrhage 175.99 14.91 161 152223 11820 79580184
Dislocation of vertebra 174.02 14.91 134 152250 7746 79584258
Duodenal ulcer perforation 173.53 14.91 388 151996 65823 79526181
Rhabdomyolysis 170.24 14.91 6 152378 103125 79488879
Somnolence 167.50 14.91 127 152257 238854 79353150
Prescribed overdose 167.25 14.91 277 152107 37606 79554398
Cardio-respiratory arrest 167.16 14.91 10 152374 108500 79483504
Sepsis 167.11 14.91 161 152223 269267 79322737
Hyperkalaemia 166.27 14.91 14 152370 114384 79477620
Inflammatory bowel disease 165.51 14.91 114 152270 5537 79586467
Depressed level of consciousness 165.47 14.91 4 152380 96648 79495356
Macule 164.80 14.91 90 152294 2867 79589137
Osteoarthritis 164.60 14.91 451 151933 86858 79505146
Helicobacter infection 163.47 14.91 391 151993 69313 79522691
Gastrointestinal haemorrhage 162.37 14.91 41 152343 147678 79444326
Cardiac failure 158.98 14.91 49 152335 154793 79437211
Neck pain 158.85 14.91 406 151978 75011 79516993
Seizure 157.60 14.91 82 152302 188752 79403252
Dyspnoea 154.87 14.91 982 151402 856043 78735961
Blister 154.36 14.91 541 151843 118935 79473069
Therapy cessation 151.73 14.91 264 152120 37298 79554706
Ankylosing spondylitis 150.70 14.91 149 152235 12056 79579948
C-reactive protein abnormal 150.52 14.91 304 152080 48063 79543941
Neutrophil count decreased 149.93 14.91 7 152377 93952 79498052
Multiple organ dysfunction syndrome 149.46 14.91 25 152359 120221 79471783
Overdose 149.32 14.91 83 152301 184123 79407881
Peripheral swelling 147.74 14.91 951 151433 268666 79323338
Sinusitis 147.45 14.91 751 151633 194750 79397254
Oxygen saturation decreased 147.38 14.91 33 152351 129014 79462990
Electrocardiogram QT prolonged 146.65 14.91 6 152378 90380 79501624
Blood cholesterol increased 146.56 14.91 421 151963 83299 79508705
Decreased immune responsiveness 145.34 14.91 104 152280 5371 79586633
Therapeutic response shortened 144.95 14.91 165 152219 15698 79576306
Uveitis 143.62 14.91 169 152215 16661 79575343
Syncope 142.39 14.91 83 152301 179366 79412638
Hypoxia 141.20 14.91 16 152368 103227 79488777
Pulmonary embolism 141.09 14.91 76 152308 171578 79420426
Intentional overdose 141.03 14.91 18 152366 105942 79486062
Pleural effusion 140.34 14.91 51 152333 145211 79446793
International normalised ratio increased 139.59 14.91 5 152379 84716 79507288
Cardiac failure congestive 137.57 14.91 50 152334 142352 79449652
Atrial fibrillation 136.30 14.91 107 152277 197779 79394225
Alopecia 134.77 14.91 829 151555 230526 79361478
Hip arthroplasty 133.74 14.91 243 152141 35513 79556491
Rhinorrhoea 133.59 14.91 383 152001 75691 79516313
Lip dry 133.53 14.91 156 152228 15262 79576742
Intentional product misuse 132.05 14.91 14 152370 95151 79496853
Coma 131.79 14.91 18 152366 100631 79491373
Facet joint syndrome 130.40 14.91 133 152251 11169 79580835
Tachycardia 129.04 14.91 91 152293 177677 79414327
Injection site haemorrhage 128.72 14.91 208 152176 27662 79564342
Gait inability 128.05 14.91 321 152063 58596 79533408
Knee arthroplasty 127.70 14.91 266 152118 42982 79549022
Hypersensitivity 127.47 14.91 898 151486 261341 79330663
Adjustment disorder with depressed mood 127.45 14.91 119 152265 8967 79583037
Product use issue 127.38 14.91 760 151624 209062 79382942
Metabolic acidosis 125.93 14.91 8 152376 82521 79509483
Joint stiffness 122.75 14.91 253 152131 40577 79551427
Swelling 122.12 14.91 770 151614 215941 79376063
Lower respiratory tract infection 122.00 14.91 530 151854 128690 79463314
Drug tolerance decreased 121.99 14.91 137 152247 12841 79579163
Bursitis 119.62 14.91 232 152152 35612 79556392
Contraindicated product administered 119.33 14.91 606 151778 156932 79435072
Dactylitis 118.95 14.91 71 152313 2686 79589318
Product prescribing error 117.84 14.91 263 152121 44550 79547454
Renal impairment 116.86 14.91 79 152305 157704 79434300
Hyperglycaemia 116.40 14.91 4 152380 70331 79521673
Retinitis 116.03 14.91 92 152292 5551 79586453
Agitation 114.86 14.91 25 152359 99690 79492314
Tremor 114.57 14.91 94 152290 169989 79422015
Loss of consciousness 114.15 14.91 92 152292 167851 79424153
Deep vein thrombosis postoperative 114.13 14.91 121 152263 10631 79581373
Off label use 113.97 14.91 1147 151237 906068 78685936
Red blood cell sedimentation rate increased 113.45 14.91 263 152121 45679 79546325
Epistaxis 113.18 14.91 36 152348 111479 79480525
Hallucination 113.06 14.91 15 152369 85730 79506274
Incorrect route of product administration 112.83 14.91 223 152161 34706 79557298
Hypoglycaemia 108.20 14.91 30 152354 101564 79490440
Product storage error 108.18 14.91 144 152240 16082 79575922
Tonsillitis 108.05 14.91 95 152289 6619 79585385
Wound infection 106.66 14.91 176 152208 23815 79568189
Red blood cell sedimentation rate 106.51 14.91 87 152297 5478 79586526
Bone erosion 104.85 14.91 149 152235 17698 79574306
Spinal pain 101.70 14.91 136 152248 15256 79576748
Fall 101.60 14.91 533 151851 487096 79104908
Injection site bruising 101.55 14.91 235 152149 40767 79551237
Lactic acidosis 101.17 14.91 9 152375 70350 79521654
Pharyngitis streptococcal 100.54 14.91 113 152271 10601 79581403
Folliculitis 100.32 14.91 282 152102 55098 79536906
Fear of injection 99.32 14.91 95 152289 7379 79584625
Blood creatine phosphokinase increased 99.09 14.91 7 152377 66083 79525921
Encephalopathy 98.61 14.91 8 152376 67389 79524615
Septic shock 98.53 14.91 56 152328 122745 79469259
Skin fissures 98.08 14.91 123 152261 12950 79579054
Peripheral venous disease 96.70 14.91 135 152249 15774 79576230
Concomitant disease aggravated 95.80 14.91 122 152262 13045 79578959
Drug reaction with eosinophilia and systemic symptoms 95.76 14.91 7 152377 64237 79527767
Maternal exposure during pregnancy 95.64 14.91 514 151870 136024 79455980
Neuropathy peripheral 95.28 14.91 78 152306 141227 79450777
Pain of skin 94.84 14.91 128 152256 14485 79577519
Tenosynovitis 94.56 14.91 132 152252 15422 79576582
Tendonitis 94.30 14.91 166 152218 23664 79568340
Injury 94.15 14.91 344 152040 77152 79514852
Movement disorder 94.10 14.91 179 152205 27080 79564924
Pulmonary oedema 94.10 14.91 26 152358 88228 79503776
Mental status changes 92.51 14.91 10 152374 66949 79525055
Joint range of motion decreased 91.66 14.91 199 152185 33083 79558921
Joint dislocation 91.63 14.91 136 152248 16803 79575201
Sacroiliitis 89.88 14.91 67 152317 3687 79588317
Autoimmune disorder 89.32 14.91 133 152251 16479 79575525
Night sweats 89.24 14.91 260 152124 51835 79540169
Hepatic function abnormal 89.08 14.91 16 152368 73091 79518913
Wrong technique in device usage process 87.86 14.91 68 152316 3960 79588044
Respiratory arrest 86.56 14.91 6 152378 57544 79534460
Laryngitis 85.65 14.91 128 152256 15911 79576093
Interstitial lung disease 85.23 14.91 55 152329 112545 79479459
Incorrect dose administered by device 85.15 14.91 73 152311 4916 79587088
Cholestasis 82.75 14.91 4 152380 52105 79539899
Product distribution issue 82.48 14.91 44 152340 1336 79590668
Exostosis 82.22 14.91 129 152255 16729 79575275
Therapy non-responder 82.11 14.91 372 152012 91933 79500071
Suicide attempt 82.00 14.91 28 152356 82904 79509100
Anti-cyclic citrullinated peptide antibody 80.84 14.91 76 152308 5776 79586228
Unresponsive to stimuli 80.58 14.91 7 152377 55781 79536223
Alanine aminotransferase abnormal 78.93 14.91 91 152293 8776 79583228
Lupus-like syndrome 78.93 14.91 114 152270 13743 79578261
Plasma cell myeloma 78.82 14.91 6 152378 53253 79538751
Mycotic allergy 78.53 14.91 44 152340 1475 79590529
Bone marrow failure 77.83 14.91 5 152379 51102 79540902
Leukopenia 77.70 14.91 65 152319 116448 79475556
Aggression 77.56 14.91 5 152379 50953 79541051
Scab 76.98 14.91 98 152286 10474 79581530
Skin disorder 76.98 14.91 188 152196 33755 79558249
Oral candidiasis 76.90 14.91 173 152211 29455 79562549
Irritable bowel syndrome 76.20 14.91 277 152107 61964 79530040
Orthostatic hypotension 76.05 14.91 9 152375 56155 79535849
Balance disorder 75.21 14.91 48 152336 98809 79493195
Hepatic cirrhosis 74.60 14.91 189 152195 34717 79557287
Blood bilirubin increased 73.50 14.91 18 152366 66214 79525790
Hypocalcaemia 72.83 14.91 6 152378 49918 79542086
Melaena 72.74 14.91 14 152370 60876 79531128
Mucosal inflammation 72.19 14.91 27 152357 75553 79516451
Toxic epidermal necrolysis 72.17 14.91 3 152381 44578 79547426
Secretion discharge 71.95 14.91 114 152270 14908 79577096
Limb discomfort 71.38 14.91 179 152205 32671 79559333
Vomiting 70.65 14.91 874 151510 664954 78927050
Hypomagnesaemia 70.23 14.91 5 152379 46906 79545098
Nail psoriasis 70.21 14.91 31 152353 614 79591390
Adverse drug reaction 70.20 14.91 282 152102 66110 79525894
Product dispensing error 69.61 14.91 105 152279 13158 79578846
Sinus congestion 69.11 14.91 131 152253 19765 79572239
Hypervolaemia 68.69 14.91 3 152381 42687 79549317
Acute respiratory failure 68.42 14.91 15 152369 59526 79532478
Neurologic neglect syndrome 67.64 14.91 51 152333 2856 79589148
Carotid artery thrombosis 67.59 14.91 52 152332 3001 79589003
Blood pressure fluctuation 67.55 14.91 22 152362 67123 79524881
Erysipelas 67.33 14.91 93 152291 10757 79581247
Cardiogenic shock 67.26 14.91 3 152381 41911 79550093
Vein rupture 66.62 14.91 44 152340 1992 79590012
Hepatic enzyme increased 66.39 14.91 585 151799 182025 79409979
Hepatocellular injury 66.02 14.91 7 152377 47586 79544418
Cognitive disorder 65.10 14.91 26 152358 69900 79522104
Accidental exposure to product 64.25 14.91 167 152217 31155 79560849
Sciatica 63.96 14.91 173 152211 33049 79558955
Urinary retention 63.60 14.91 15 152369 56615 79535389
Gait disturbance 63.59 14.91 641 151743 206865 79385139
Rebound psoriasis 63.21 14.91 21 152363 182 79591822
Upper gastrointestinal haemorrhage 63.16 14.91 4 152380 41376 79550628
Ascites 62.72 14.91 33 152351 75529 79516475
Deep vein thrombosis 62.14 14.91 84 152300 120835 79471169
Generalised tonic-clonic seizure 62.10 14.91 6 152378 43904 79548100
Altered state of consciousness 61.94 14.91 6 152378 43816 79548188
Dyspnoea exertional 60.02 14.91 47 152337 87026 79504978
Joint ankylosis 59.22 14.91 42 152342 2138 79589866
Respiratory tract congestion 59.21 14.91 123 152261 19831 79572173
Breast cancer stage III 59.15 14.91 83 152301 9743 79582261
Disorientation 59.00 14.91 23 152361 62753 79529251
Shock 58.91 14.91 7 152377 43541 79548463
Rash maculo-papular 58.89 14.91 17 152367 56061 79535943
Scratch 58.50 14.91 76 152308 8287 79583717
Dry skin 58.21 14.91 271 152113 67724 79524280
Localised infection 58.19 14.91 181 152203 37394 79554610
Pustular psoriasis 58.09 14.91 58 152326 4748 79587256
Chronic kidney disease 57.77 14.91 27 152357 66127 79525877
Pneumonitis 57.69 14.91 22 152362 60838 79531166
Pneumonia aspiration 57.45 14.91 28 152356 66939 79525065
Cytomegalovirus infection 57.33 14.91 7 152377 42637 79549367
C-reactive protein 56.37 14.91 58 152326 4921 79587083
Lower limb fracture 56.32 14.91 132 152252 23083 79568921
Ventricular tachycardia 56.09 14.91 7 152377 41928 79550076
Liver function test abnormal 55.25 14.91 27 152357 64448 79527556
Spondylitis 55.17 14.91 56 152328 4675 79587329
Heart rate decreased 55.07 14.91 33 152351 70283 79521721
Tubulointerstitial nephritis 54.67 14.91 5 152379 38230 79553774
Jaundice 54.52 14.91 17 152367 53332 79538672
Cerebral haemorrhage 54.42 14.91 21 152363 57652 79534352
Urticaria 53.83 14.91 566 151818 184635 79407369
Pulmonary hypertension 53.48 14.91 13 152371 48067 79543937
Hypoaesthesia 53.01 14.91 550 151834 178802 79413202
Blood potassium decreased 52.87 14.91 12 152372 46500 79545504
Disability 52.53 14.91 107 152277 17013 79574991
Pericardial effusion 52.42 14.91 12 152372 46225 79545779
Foot deformity 52.12 14.91 131 152253 23943 79568061
Haematocrit decreased 52.05 14.91 26 152358 61286 79530718
Dyskinesia 52.01 14.91 11 152373 44762 79547242
Psoriasis area severity index increased 51.51 14.91 16 152368 109 79591895
Nail disorder 51.41 14.91 86 152298 11766 79580238
Stevens-Johnson syndrome 51.27 14.91 7 152377 39159 79552845
Cutaneous T-cell lymphoma 51.19 14.91 42 152342 2661 79589343
Tonsillar ulcer 51.10 14.91 22 152362 409 79591595
Hypophagia 50.98 14.91 12 152372 45355 79546649
Red blood cell count decreased 50.95 14.91 23 152361 57490 79534514
Multiple sclerosis relapse 50.94 14.91 13 152371 46520 79545484
Erythema 50.87 14.91 651 151733 222639 79369365
Back pain 50.77 14.91 840 151544 303340 79288664
Coagulopathy 50.71 14.91 5 152379 36001 79556003
Psychotic disorder 50.57 14.91 9 152375 41393 79550611
Device defective 49.88 14.91 36 152348 1884 79590120
Sinus tachycardia 49.76 14.91 6 152378 36902 79555102
Insurance issue 49.63 14.91 58 152326 5675 79586329
Coronary artery disease 49.51 14.91 32 152352 65442 79526562
Haematemesis 49.36 14.91 19 152365 52245 79539759
Respiratory distress 49.13 14.91 25 152359 58314 79533690
Colitis ulcerative 48.93 14.91 162 152222 34580 79557424
Abnormal behaviour 48.91 14.91 6 152378 36415 79555589
Obesity 48.77 14.91 163 152221 34962 79557042
Fungal infection 48.75 14.91 183 152201 41565 79550439
Muscle injury 48.75 14.91 203 152181 48358 79543646
Cystitis 48.74 14.91 215 152169 52517 79539487
Spinal fusion surgery 48.73 14.91 55 152329 5183 79586821
Onychomadesis 48.69 14.91 55 152329 5187 79586817
Confusional state 48.51 14.91 382 152002 317615 79274389
SARS-CoV-2 test positive 48.16 14.91 83 152301 11633 79580371
Spondyloarthropathy 47.94 14.91 28 152356 1017 79590987
Thrombosis 47.85 14.91 54 152330 84046 79507958
Sneezing 47.84 14.91 112 152272 19571 79572433
Acne 47.81 14.91 137 152247 27053 79564951
Palmoplantar pustulosis 47.75 14.91 23 152361 560 79591444
Haematoma 47.62 14.91 20 152364 52175 79539829
Tenderness 47.41 14.91 125 152259 23517 79568487
Eosinophilia 47.15 14.91 14 152370 45331 79546673
Pancreatitis acute 46.91 14.91 18 152366 49586 79542418
Influenza like illness 46.86 14.91 265 152119 71442 79520562
Lymphocyte count decreased 46.68 14.91 16 152368 47273 79544731
Symptom recurrence 46.03 14.91 37 152347 2277 79589727
Pallor 45.97 14.91 19 152365 50043 79541961
Self-consciousness 45.90 14.91 14 152370 89 79591915
Blood alkaline phosphatase increased 45.63 14.91 33 152351 63631 79528373
Skin burning sensation 45.62 14.91 87 152297 13185 79578819
Subdural haematoma 45.24 14.91 4 152380 31430 79560574
Musculoskeletal discomfort 45.12 14.91 110 152274 19725 79572279
Blood creatinine increased 44.94 14.91 149 152235 154908 79437096
Skin injury 44.70 14.91 43 152341 3363 79588641
Acute myeloid leukaemia 44.26 14.91 4 152380 30881 79561123
Road traffic accident 44.20 14.91 183 152201 43481 79548523
Hypercholesterolaemia 44.19 14.91 120 152264 22975 79569029
X-ray abnormal 44.10 14.91 55 152329 5758 79586246
Atelectasis 44.09 14.91 5 152379 32252 79559752
Blood urea increased 44.03 14.91 19 152365 48771 79543233
Drug resistance 43.95 14.91 13 152371 42200 79549804
Disturbance in attention 43.95 14.91 21 152363 50780 79541224
Tachypnoea 43.75 14.91 5 152379 32058 79559946
Venous injury 43.56 14.91 24 152360 778 79591226
Lupus vulgaris 43.46 14.91 42 152342 3304 79588700
Myocardial infarction 43.04 14.91 193 152191 183936 79408068
Stress 43.00 14.91 280 152104 79332 79512672
Full blood count abnormal 43.00 14.91 12 152372 40462 79551542
Ligament calcification 42.58 14.91 16 152368 205 79591799
Cerebral infarction 42.49 14.91 17 152367 45659 79546345
Adjustment disorder 42.42 14.91 45 152339 3955 79588049
Haemorrhage 42.22 14.91 68 152316 91050 79500954
Acute myocardial infarction 42.18 14.91 51 152333 76985 79515019
Presyncope 42.10 14.91 13 152371 41041 79550963
Blood glucose increased 41.83 14.91 99 152285 114876 79477128
Oedema peripheral 41.83 14.91 296 152088 251992 79340012
Aspartate aminotransferase increased 41.73 14.91 131 152253 138510 79453494
Therapeutic response decreased 41.69 14.91 244 152140 66609 79525395
Acute respiratory distress syndrome 41.65 14.91 16 152368 44051 79547953
Live birth 41.63 14.91 103 152281 18641 79573363
Myoclonus 41.26 14.91 3 152381 27657 79564347
Panniculitis 41.18 14.91 80 152304 12291 79579713
Granuloma 41.17 14.91 64 152320 8233 79583771
Rash 40.92 14.91 1418 150966 576940 79015064
Blood calcium decreased 40.92 14.91 6 152378 31813 79560191
Dysgeusia 40.51 14.91 30 152354 57147 79534857
Haematuria 40.49 14.91 43 152341 68793 79523211
Diabetic ketoacidosis 40.43 14.91 8 152376 34114 79557890
Hypermobility syndrome 40.25 14.91 20 152364 522 79591482
Guttate psoriasis 40.00 14.91 19 152365 448 79591556
Arrhythmia 39.84 14.91 35 152349 61237 79530767
Pustule 39.48 14.91 32 152352 1993 79590011
Gastrointestinal pain 39.44 14.91 69 152315 9786 79582218
Blood lactate dehydrogenase increased 39.11 14.91 13 152371 39157 79552847
Leukocytosis 39.09 14.91 17 152367 43438 79548566
Hypothyroidism 39.08 14.91 26 152358 52366 79539638
Musculoskeletal pain 38.79 14.91 331 152053 102023 79489981
Blood parathyroid hormone decreased 38.62 14.91 71 152313 10465 79581539
Personality disorder 38.62 14.91 53 152331 6093 79585911
Blood pressure decreased 38.34 14.91 83 152301 99383 79492621
Obstructive airways disorder 38.07 14.91 7 152377 31452 79560552
Papule 37.97 14.91 58 152326 7349 79584655
Tongue disorder 37.84 14.91 83 152301 13892 79578112
Intentional self-injury 37.58 14.91 8 152376 32411 79559593
Hepatic failure 37.40 14.91 37 152347 61175 79530829
Hidradenitis 37.28 14.91 37 152347 3007 79588997
Gastric disorder 37.19 14.91 156 152228 37277 79554727
Flushing 37.14 14.91 70 152314 88198 79503806
Electrolyte imbalance 37.10 14.91 7 152377 30874 79561130
Tooth abscess 36.98 14.91 90 152294 16120 79575884
Dysstasia 36.98 14.91 127 152257 27619 79564385
Brain oedema 36.95 14.91 3 152381 25260 79566744
Intestinal obstruction 36.88 14.91 18 152366 43002 79549002
Lymphopenia 36.55 14.91 7 152377 30550 79561454
Axial spondyloarthritis 35.92 14.91 19 152365 567 79591437
Bone lesion 35.63 14.91 50 152334 5869 79586135
Walking aid user 35.47 14.91 67 152317 10081 79581923
Mitral valve incompetence 35.35 14.91 6 152378 28559 79563445
Drug dependence 35.04 14.91 17 152367 40752 79551252
Oral lichen planus 34.93 14.91 21 152363 805 79591199
Chronic obstructive pulmonary disease 34.85 14.91 69 152315 85350 79506654
Burning sensation 34.64 14.91 211 152173 58421 79533583
Adverse event 34.51 14.91 215 152169 59999 79532005
Cellulitis 34.39 14.91 339 152045 108721 79483283
Ataxia 33.93 14.91 4 152380 25035 79566969
Renal tubular necrosis 33.93 14.91 4 152380 25035 79566969
Pancreatitis 33.86 14.91 49 152335 68526 79523478
Acute hepatic failure 33.77 14.91 8 152376 30105 79561899
Ejection fraction decreased 33.61 14.91 12 152372 34565 79557439
Nasal congestion 33.59 14.91 256 152128 76296 79515708
Ileus 33.57 14.91 5 152379 26206 79565798
Accident 32.99 14.91 60 152324 8771 79583233
Eczema 32.98 14.91 160 152224 40658 79551346
Subarachnoid haemorrhage 32.92 14.91 4 152380 24461 79567543
Hepatotoxicity 32.59 14.91 30 152354 51322 79540682
Hypothermia 32.45 14.91 3 152381 22743 79569261
Hepatic encephalopathy 32.40 14.91 4 152380 24162 79567842
Asthenia 32.34 14.91 738 151646 510951 79081053
Product label confusion 32.34 14.91 26 152358 1600 79590404
Myelodysplastic syndrome 32.16 14.91 9 152375 30292 79561712
Lower respiratory tract infection viral 31.98 14.91 23 152361 1197 79590807
Impaired healing 31.92 14.91 281 152103 87374 79504630
Cough 31.86 14.91 922 151462 365867 79226137
Cardiomyopathy 31.57 14.91 8 152376 28766 79563238
Sleep disorder 31.38 14.91 275 152109 85402 79506602
Drug ineffective for unapproved indication 31.27 14.91 31 152353 51207 79540797
Tuberculosis 31.13 14.91 81 152303 15117 79576887
Dermatitis psoriasiform 30.64 14.91 32 152352 2762 79589242
Injection site pain 30.59 14.91 381 152003 129457 79462547
Full blood count decreased 30.32 14.91 7 152377 26812 79565192
Kidney infection 29.98 14.91 101 152283 21750 79570254
Rectal haemorrhage 29.96 14.91 63 152321 76237 79515767
Headache 29.87 14.91 1531 150853 652241 78939763
Transient ischaemic attack 29.80 14.91 34 152350 52661 79539343
Fatigue 29.68 14.91 2109 150275 927618 78664386
Cyanosis 29.64 14.91 6 152378 25176 79566828
Wheezing 29.51 14.91 347 152037 116317 79475687
Muscle swelling 29.46 14.91 19 152365 826 79591178
Pyoderma gangrenosum 29.42 14.91 38 152346 4120 79587884
Adrenal insufficiency 29.25 14.91 9 152375 28478 79563526
Pain in jaw 29.24 14.91 27 152357 46124 79545880
Anaphylactic reaction 28.98 14.91 74 152310 83669 79508335
Rheumatoid nodule 28.87 14.91 86 152298 17352 79574652
Rheumatoid lung 28.80 14.91 38 152346 4207 79587797
Pneumocystis jirovecii pneumonia 28.79 14.91 13 152371 32495 79559509
Onycholysis 28.67 14.91 27 152357 2056 79589948
Motor dysfunction 28.63 14.91 77 152307 14656 79577348
Myopathy 28.58 14.91 3 152381 20560 79571444
Device related infection 28.42 14.91 15 152369 34279 79557725
Joint injury 28.38 14.91 127 152257 31208 79560796
Blood sodium decreased 28.38 14.91 14 152370 33241 79558763
Therapeutic product effect delayed 28.36 14.91 32 152352 3014 79588990
Sinus disorder 28.36 14.91 101 152283 22363 79569641
Haemophagocytic lymphohistiocytosis 28.35 14.91 4 152380 21833 79570171
Myocarditis 28.17 14.91 4 152380 21729 79570275
Tinnitus 28.02 14.91 26 152358 44307 79547697
Lung infiltration 27.94 14.91 5 152379 22907 79569097
Polyneuropathy 27.92 14.91 6 152378 24145 79567859
Abscess limb 27.86 14.91 49 152335 6978 79585026
Bacteraemia 27.74 14.91 14 152370 32810 79559194
Injection site papule 27.65 14.91 19 152365 919 79591085
Gastrooesophageal reflux disease 27.64 14.91 104 152280 104142 79487862
Ear infection fungal 27.58 14.91 12 152372 229 79591775
Skin infection 27.43 14.91 87 152297 18158 79573846
Feeling abnormal 27.40 14.91 442 151942 158757 79433247
Supraventricular tachycardia 27.38 14.91 4 152380 21266 79570738
Proteinuria 27.26 14.91 14 152370 32488 79559516
Metastases to liver 27.23 14.91 10 152374 28304 79563700
Bronchiectasis 27.05 14.91 5 152379 22381 79569623
Musculoskeletal deformity 27.03 14.91 23 152361 1533 79590471
Rhesus antigen positive 26.91 14.91 10 152374 124 79591880
Tinea pedis 26.86 14.91 28 152356 2412 79589592
Premature delivery 26.78 14.91 6 152378 23461 79568543
Body temperature decreased 26.69 14.91 127 152257 32018 79559986
Loose body in joint 26.38 14.91 21 152363 1274 79590730
Hallucination, auditory 26.38 14.91 4 152380 20689 79571315
Skin discomfort 26.34 14.91 17 152367 740 79591264
Induration 26.29 14.91 25 152359 1927 79590077
Skin irritation 26.28 14.91 63 152321 11177 79580827
Genital candidiasis 26.01 14.91 10 152374 137 79591867
Inflammatory pain 25.87 14.91 19 152365 1022 79590982
Cytopenia 25.85 14.91 4 152380 20379 79571625
Cardiac failure acute 25.71 14.91 3 152381 18926 79573078
Anosmia 25.64 14.91 54 152330 8790 79583214
Clostridium difficile colitis 25.49 14.91 15 152369 32268 79559736
General physical health deterioration 25.31 14.91 697 151687 274541 79317463
Hypoalbuminaemia 25.22 14.91 5 152379 21292 79570712
Chronic disease 25.12 14.91 10 152374 151 79591853
Urinary incontinence 24.68 14.91 25 152359 40884 79551120
Dyshidrotic eczema 24.65 14.91 15 152369 588 79591416
Nausea 24.61 14.91 1539 150845 955657 78636347
Xyphoid retraction 24.43 14.91 10 152374 163 79591841
Abscess sweat gland 24.38 14.91 6 152378 14 79591990
Sensory loss 24.35 14.91 67 152317 12924 79579080
Granuloma skin 24.29 14.91 54 152330 9120 79582884
Angiocardiogram 24.19 14.91 11 152373 234 79591770
Poisoning 24.18 14.91 9 152375 25263 79566741
Hyperthermia 24.15 14.91 3 152381 18034 79573970
Petechiae 23.99 14.91 5 152379 20560 79571444
Aplastic anaemia 23.92 14.91 3 152381 17902 79574102
Hepatic cytolysis 23.83 14.91 11 152373 27140 79564864
Peritonitis 23.63 14.91 12 152372 28024 79563980
Pharyngitis 23.61 14.91 95 152289 22280 79569724
Product substitution issue 23.48 14.91 5 152379 20251 79571753
Muscle twitching 23.39 14.91 9 152375 24755 79567249
No adverse event 23.28 14.91 22 152362 37170 79554834
Tooth infection 23.20 14.91 84 152300 18748 79573256
Iron deficiency anaemia 23.16 14.91 10 152374 25662 79566342
Fluid retention 23.15 14.91 63 152321 69746 79522258
Skin swelling 22.82 14.91 33 152351 3981 79588023
Anuria 22.67 14.91 6 152378 20957 79571047
Collagen-vascular disease 22.63 14.91 8 152376 85 79591919
Alanine aminotransferase increased 22.62 14.91 200 152184 162370 79429634
Tricuspid valve incompetence 22.57 14.91 5 152379 19707 79572297
Pseudomonas infection 22.57 14.91 6 152378 20897 79571107
Gastrointestinal disorder 22.43 14.91 343 152041 121862 79470142
Body surface area increased 22.25 14.91 9 152375 142 79591862
Mania 22.23 14.91 4 152380 18256 79573748
Renal injury 22.22 14.91 3 152381 16924 79575080
Lichen planus 22.13 14.91 27 152357 2764 79589240
Atrial flutter 21.90 14.91 7 152377 21618 79570386
Eye infection 21.87 14.91 61 152323 11859 79580145
Manufacturing product shipping issue 21.84 14.91 8 152376 95 79591909
Ear pain 21.82 14.91 122 152262 32747 79559257
Troponin increased 21.82 14.91 5 152379 19250 79572754
Basal cell carcinoma 21.75 14.91 134 152250 37241 79554763
Irritability 21.72 14.91 28 152356 41116 79550888
Gamma-glutamyltransferase increased 21.59 14.91 45 152339 54635 79537369
Sudden death 21.56 14.91 8 152376 22503 79569501
Genital cyst 21.56 14.91 7 152377 56 79591948
Malnutrition 21.55 14.91 8 152376 22494 79569510
Nasal discomfort 21.44 14.91 38 152346 5445 79586559
Aspiration 21.37 14.91 6 152378 20152 79571852
Restlessness 21.25 14.91 35 152349 46457 79545547
Vulval cancer stage III 21.18 14.91 5 152379 9 79591995
Cardiomegaly 21.15 14.91 12 152372 26340 79565664
Rales 21.11 14.91 6 152378 19995 79572009
Ulcer 21.07 14.91 113 152271 29859 79562145
HLA-B*27 positive 20.91 14.91 8 152376 108 79591896
Body mass index abnormal 20.89 14.91 10 152374 240 79591764
Breast cancer 20.86 14.91 123 152261 33658 79558346
Heart rate irregular 20.85 14.91 19 152365 32660 79559344
Coronavirus infection 20.84 14.91 45 152339 7452 79584552
Meningitis streptococcal 20.82 14.91 9 152375 169 79591835
Laboratory test abnormal 20.81 14.91 14 152370 28034 79563970
Diplopia 20.71 14.91 20 152364 33446 79558558
Anaphylactic shock 20.60 14.91 23 152361 35973 79556031
Contusion 20.58 14.91 399 151985 148377 79443627
Tendon pain 20.58 14.91 38 152346 5620 79586384
Dialysis 20.51 14.91 5 152379 18457 79573547
Gastrointestinal infection 20.39 14.91 58 152326 11403 79580601
Eating disorder 20.36 14.91 86 152298 20611 79571393
Tinea versicolour 20.32 14.91 11 152373 344 79591660
Actinic keratosis 20.02 14.91 39 152345 6003 79586001
Red cell distribution width decreased 19.99 14.91 22 152362 2016 79589988
Prothrombin time prolonged 19.94 14.91 4 152380 16895 79575109
Hyperhidrosis 19.94 14.91 189 152195 151303 79440701
Wrong schedule 19.93 14.91 11 152373 358 79591646
Palate injury 19.92 14.91 7 152377 73 79591931
Ill-defined disorder 19.91 14.91 203 152181 65672 79526332
Medication error 19.85 14.91 66 152318 68576 79523428
Respiratory tract infection 19.80 14.91 160 152224 48529 79543475
Metastases to bone 19.78 14.91 11 152373 24416 79567588
Liver function test increased 19.74 14.91 137 152247 39636 79552368
Small intestinal obstruction 19.72 14.91 14 152370 27258 79564746
Device issue 19.60 14.91 103 152281 27005 79564999
Hepatic enzyme abnormal 19.59 14.91 45 152339 7765 79584239
Hepatitis 19.47 14.91 49 152335 55678 79536326
Oedema 19.46 14.91 329 152055 119251 79472753
Erythematotelangiectatic rosacea 19.41 14.91 5 152379 15 79591989
Epilepsy 19.39 14.91 30 152354 40830 79551174
Bronchitis 19.32 14.91 354 152030 130290 79461714
Lip ulceration 19.26 14.91 23 152361 2302 79589702
Groin infection 19.25 14.91 13 152371 611 79591393
Scarlet fever 19.23 14.91 8 152376 136 79591868
Bronchospasm 19.00 14.91 12 152372 24847 79567157
Drug-device interaction 18.97 14.91 7 152377 85 79591919
Retching 18.89 14.91 5 152379 17462 79574542
Hypertensive crisis 18.88 14.91 8 152376 20762 79571242
Vascular access complication 18.76 14.91 22 152362 2160 79589844
Vision blurred 18.65 14.91 122 152262 105776 79486228
Dermatitis exfoliative generalised 18.47 14.91 42 152342 7199 79584805
Skin necrosis 18.45 14.91 76 152308 18011 79573993
Latent tuberculosis 18.25 14.91 27 152357 3326 79588678
Product supply issue 18.20 14.91 21 152363 2027 79589977
Affect lability 18.14 14.91 55 152329 11204 79580800
Toxic skin eruption 18.11 14.91 10 152374 22283 79569721
Aspergillus infection 18.04 14.91 7 152377 19154 79572850
Rash pustular 17.99 14.91 55 152329 11256 79580748
Prescribed underdose 17.93 14.91 107 152277 29407 79562597
Decubitus ulcer 17.92 14.91 4 152380 15683 79576321
Papulopustular rosacea 17.92 14.91 5 152379 22 79591982
Unevaluable event 17.81 14.91 51 152333 55534 79536470
Visual acuity reduced 17.79 14.91 18 152366 29451 79562553
Neutrophil count increased 17.69 14.91 18 152366 29378 79562626
Diverticulitis 17.63 14.91 149 152235 45787 79546217
Product availability issue 17.60 14.91 29 152355 3918 79588086
Finger deformity 17.59 14.91 42 152342 7432 79584572
Angioimmunoblastic T-cell lymphoma 17.59 14.91 11 152373 453 79591551
Circulatory collapse 17.55 14.91 28 152356 37640 79554364
Drug tolerance 17.53 14.91 46 152338 8629 79583375
Oligoarthritis 17.51 14.91 13 152371 711 79591293
Atrioventricular block complete 17.50 14.91 5 152379 16605 79575399
Skin oedema 17.43 14.91 19 152365 1722 79590282
Otorrhoea 17.40 14.91 19 152365 1726 79590278
Urosepsis 17.39 14.91 15 152369 26480 79565524
Blood magnesium decreased 17.34 14.91 5 152379 16507 79575497
Cutaneous lymphoma 17.31 14.91 9 152375 259 79591745
Myocardial ischaemia 17.30 14.91 14 152370 25505 79566499
Viral infection 17.30 14.91 141 152243 42875 79549129
Lipase increased 17.27 14.91 5 152379 16461 79575543
Aphthous ulcer 17.26 14.91 71 152313 16818 79575186
Terminal insomnia 17.18 14.91 16 152368 1201 79590803
Mouth ulceration 17.18 14.91 129 152255 38265 79553739
Complication associated with device 17.13 14.91 6 152378 17490 79574514
Metastases to central nervous system 17.12 14.91 5 152379 16370 79575634
Respiratory rate increased 17.10 14.91 10 152374 21590 79570414
Pigmentation disorder 17.10 14.91 35 152349 5583 79586421
Gastric ulcer 16.96 14.91 24 152360 33881 79558123
Oral pustule 16.91 14.91 9 152375 272 79591732
Paraesthesia oral 16.90 14.91 9 152375 20462 79571542
Pregnancy on contraceptive 16.87 14.91 14 152370 901 79591103
Dizziness 16.87 14.91 828 151556 525613 79066391
Polyuria 16.81 14.91 4 152380 15010 79576994
Oral lichenoid reaction 16.78 14.91 7 152377 120 79591884
Peritonsillar abscess 16.73 14.91 14 152370 912 79591092
Benign laryngeal neoplasm 16.64 14.91 5 152379 30 79591974
Nightmare 16.54 14.91 15 152369 25846 79566158
Muscle spasticity 16.51 14.91 83 152301 21392 79570612
Cell marker increased 16.44 14.91 12 152372 639 79591365
Onychalgia 16.39 14.91 14 152370 938 79591066
Blindness 16.39 14.91 18 152366 28365 79563639
Renal disorder 16.33 14.91 35 152349 42070 79549934
Tongue ulceration 16.32 14.91 29 152355 4164 79587840
Clostridium difficile infection 16.13 14.91 36 152348 42649 79549355
Abdominal pain upper 16.07 14.91 550 151834 223269 79368735
Oesophageal infection 16.07 14.91 12 152372 662 79591342
Immune thrombocytopenia 15.96 14.91 7 152377 17798 79574206
Femur fracture 15.95 14.91 31 152353 38621 79553383
Energy increased 15.84 14.91 25 152359 3257 79588747
Epstein-Barr virus infection 15.83 14.91 4 152380 14412 79577592
White blood cell count increased 15.81 14.91 81 152303 74552 79517452
Otitis externa 15.61 14.91 21 152363 2369 79589635
Osteoporosis 15.52 14.91 165 152219 53947 79538057
Iritis 15.44 14.91 27 152357 3828 79588176
Hemiplegia 15.42 14.91 63 152321 14876 79577128
Haemoptysis 15.41 14.91 55 152329 55944 79536060
Stomatitis 15.32 14.91 378 152006 146379 79445625
Ecchymosis 15.26 14.91 5 152379 15201 79576803
Oral discomfort 15.09 14.91 47 152337 9713 79582291
Ischaemic stroke 15.09 14.91 25 152359 33106 79558898
Skin ulcer 15.02 14.91 164 152220 53986 79538018
Bone cyst 15.01 14.91 25 152359 3408 79588596

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC10 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000191494 Interleukin-17A Antagonists
FDA EPC N0000191495 Interleukin-17A Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Psoriatic arthritis indication 156370009 DOID:9008
Plaque psoriasis indication 200965009
Pustular psoriasis indication 200973000
Non-radiographic axial spondyloarthritis indication 713777005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-17A Cytokine ANTIBODY BINDING SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D09967 KEGG_DRUG
4034154 VUID
N0000191427 NUI
4034154 VANDF
CHEMBL1743068 ChEMBL_ID
C555450 MESH_SUPPLEMENTAL_RECORD_UI
8078 IUPHAR_LIGAND_ID
DB09029 DRUGBANK_ID
1599788 RXNORM
232493 MMSL
30871 MMSL
d08341 MMSL
015879 NDDF
708822004 SNOMEDCT_US
714689007 SNOMEDCT_US
C3179547 UMLSCUI
9182 INN_ID
DLG4EML025 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0639 INJECTION 150 mg SUBCUTANEOUS BLA 32 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0639 INJECTION 150 mg SUBCUTANEOUS BLA 32 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0639 INJECTION 150 mg SUBCUTANEOUS BLA 32 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1056 INJECTION 75 mg SUBCUTANEOUS BLA 32 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1056 INJECTION 75 mg SUBCUTANEOUS BLA 32 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1056 INJECTION 75 mg SUBCUTANEOUS BLA 32 sections
COSENTYX HUMAN PRESCRIPTION DRUG LABEL 1 0078-1070 INJECTION 300 mg SUBCUTANEOUS BLA 32 sections