tocilizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4933 375823-41-9

Description:

MoleculeDescription

Synonyms:

  • tocilizumab
  • MRA
  • RoActemra
  • actemra
  • R-1569
  • tocilizumab (genetical recombination)
a humanised anti-interleukin-6 receptor monoclonal antibody
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 16, 2009 EMA
Jan. 8, 2010 FDA GENENTECH
March 6, 2008 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 5650.22 14.61 14249 299989 805084 49485802
Contraindicated product administered 3991.52 14.61 4763 309475 144195 50146691
Joint swelling 3260.76 14.61 5615 308623 239671 50051215
Drug intolerance 3025.88 14.61 5103 309135 214001 50076885
Treatment failure 2960.32 14.61 3946 310292 133691 50157195
Synovitis 2920.17 14.61 3716 310522 120149 50170737
Arthropathy 2240.78 14.61 3726 310512 154180 50136706
Therapeutic product effect decreased 2133.67 14.61 3360 310878 132690 50158196
Pemphigus 1976.24 14.61 3034 311204 117132 50173754
Systemic lupus erythematosus 1843.04 14.61 3204 311034 137418 50153468
Swelling 1697.68 14.61 3806 310432 197066 50093820
Glossodynia 1561.76 14.61 2670 311568 112899 50177987
Pain 1520.80 14.61 7345 306893 571558 49719328
Hand deformity 1452.28 14.61 2389 311849 97810 50193076
Arthralgia 1421.07 14.61 5927 308311 432775 49858111
Abdominal discomfort 1304.82 14.61 3765 310473 227876 50063010
Rheumatoid arthritis 1196.53 14.61 3350 310888 199200 50091686
Hypersensitivity 1158.41 14.61 3442 310796 211719 50079167
Hepatic enzyme increased 1152.08 14.61 2597 311641 134783 50156103
Alopecia 1091.88 14.61 3672 310566 241375 50049511
Rheumatoid factor positive 1083.53 14.61 1439 312799 48420 50242466
Infusion related reaction 1049.05 14.61 2853 311385 166704 50124182
Wound 1017.06 14.61 2114 312124 103680 50187206
Anti-cyclic citrullinated peptide antibody positive 940.89 14.61 1622 312616 68965 50221921
Death 936.97 14.61 425 313813 324954 49965932
Rash 908.10 14.61 5208 309030 432263 49858623
Toxicity to various agents 885.89 14.61 132 314106 212367 50078519
C-reactive protein abnormal 851.95 14.61 955 313283 26854 50264032
Acute kidney injury 848.92 14.61 189 314049 227869 50063017
Lower respiratory tract infection 839.43 14.61 1837 312401 93364 50197522
Peripheral swelling 827.10 14.61 2983 311255 202953 50087933
Musculoskeletal stiffness 821.31 14.61 2189 312049 126292 50164594
Infection 807.83 14.61 2635 311603 170319 50120567
Drug interaction 796.18 14.61 140 314098 199481 50091405
Pericarditis 784.89 14.61 1597 312641 77092 50213794
Red blood cell sedimentation rate abnormal 725.05 14.61 685 313553 15658 50275228
Anaemia 687.75 14.61 355 313883 252101 50038785
Loss of personal independence in daily activities 678.83 14.61 1405 312833 68645 50222241
Ill-defined disorder 658.64 14.61 1202 313036 53452 50237434
Discomfort 656.76 14.61 1811 312427 106569 50184317
Muscle injury 616.99 14.61 943 313295 36168 50254718
Folliculitis 612.07 14.61 968 313270 38257 50252629
Impaired healing 606.24 14.61 1339 312899 68447 50222439
Product use issue 576.47 14.61 2138 312100 147337 50143549
Dehydration 551.72 14.61 134 314104 152315 50138571
Maternal exposure during pregnancy 502.33 14.61 2144 312094 157634 50133252
Irritable bowel syndrome 492.62 14.61 1027 313211 50414 50240472
Hyponatraemia 490.03 14.61 26 314212 96113 50194773
Drug hypersensitivity 489.94 14.61 2944 311294 248066 50042820
Product dose omission issue 476.33 14.61 275 313963 183563 50107323
Red blood cell sedimentation rate increased 475.63 14.61 738 313500 28678 50262208
Febrile neutropenia 469.32 14.61 36 314202 97631 50193255
Dizziness 451.10 14.61 921 313317 345448 49945438
Decreased appetite 450.25 14.61 353 313885 200570 50090316
Helicobacter infection 448.98 14.61 969 313269 48733 50242153
Nausea 444.13 14.61 2572 311666 702826 49588060
Sleep disorder due to general medical condition, insomnia type 438.95 14.61 738 313500 30709 50260177
Duodenal ulcer perforation 431.34 14.61 906 313332 44705 50246181
Nasopharyngitis 423.35 14.61 2335 311903 190592 50100294
Therapeutic product effect incomplete 419.96 14.61 1387 312851 90128 50200758
Blister 413.07 14.61 1318 312920 84100 50206786
Constipation 412.62 14.61 329 313909 185379 50105507
Seizure 410.32 14.61 112 314126 117762 50173124
Intentional product use issue 400.71 14.61 1218 313020 75700 50215186
Tremor 400.29 14.61 109 314129 114794 50176092
Anxiety 391.63 14.61 317 313921 177289 50113597
Injection site pain 383.61 14.61 107 314131 110917 50179969
Diarrhoea 377.17 14.61 2132 312106 586344 49704542
C-reactive protein increased 377.07 14.61 1085 313153 65389 50225497
Intentional overdose 370.77 14.61 3 314235 62501 50228385
Sinusitis 360.56 14.61 2044 312194 168514 50122372
Bone erosion 358.92 14.61 402 313836 11285 50279601
Overdose 352.29 14.61 92 314146 99635 50191251
Condition aggravated 345.02 14.61 3078 311160 293980 49996906
Rheumatoid nodule 339.06 14.61 407 313831 12328 50278558
Somnolence 325.25 14.61 290 313948 154695 50136191
Cardiac arrest 323.87 14.61 63 314175 83588 50207298
Hypotension 323.58 14.61 606 313632 234863 50056023
Knee arthroplasty 322.69 14.61 698 313540 35148 50255738
Depression 315.38 14.61 337 313901 165086 50125800
Renal failure 314.51 14.61 134 314104 106499 50184387
Off label use 311.65 14.61 4393 309845 470033 49820853
Cardiac failure congestive 309.40 14.61 72 314166 84310 50206576
Blood iron abnormal 304.73 14.61 213 314025 3113 50287773
Thrombocytopenia 300.39 14.61 213 314025 127460 50163426
Asthenia 298.31 14.61 1001 313237 318041 49972845
Dyspnoea 296.40 14.61 2089 312149 545519 49745367
Bradycardia 295.17 14.61 29 314209 64397 50226489
Electrocardiogram QT prolonged 288.55 14.61 7 314231 51879 50239007
Tachycardia 286.89 14.61 130 314108 99633 50191253
Muscle spasms 283.06 14.61 219 314019 125334 50165552
Neuropathy peripheral 279.94 14.61 125 314113 96632 50194254
Gastrointestinal disorder 277.03 14.61 1242 312996 93214 50197672
Hip arthroplasty 275.57 14.61 594 313644 29835 50261051
Haemoglobin decreased 275.43 14.61 231 314007 126985 50163901
Hypokalaemia 275.20 14.61 101 314137 87891 50202995
Joint stiffness 270.32 14.61 588 313650 29720 50261166
Suicide attempt 269.94 14.61 12 314226 51720 50239166
Oedema peripheral 264.69 14.61 356 313882 157605 50133281
Vomiting 261.81 14.61 1732 312506 459026 49831860
Mobility decreased 261.10 14.61 1086 313152 78862 50212024
Hypoglycaemia 256.64 14.61 20 314218 53561 50237325
Skin ulcer 256.49 14.61 632 313606 34686 50256200
Malignant neoplasm progression 254.00 14.61 56 314182 68068 50222818
Feeling abnormal 253.55 14.61 243 313995 125249 50165637
Balance disorder 253.35 14.61 63 314175 70527 50220359
Hyperkalaemia 251.43 14.61 11 314227 48078 50242808
Cardio-respiratory arrest 247.56 14.61 24 314214 53868 50237018
Inflammation 245.40 14.61 845 313393 56067 50234819
Respiratory failure 242.29 14.61 132 314106 91049 50199837
Coma 239.78 14.61 34 314204 56845 50234041
Osteoporosis 234.84 14.61 712 313526 44167 50246719
Rheumatic fever 234.21 14.61 395 313843 16472 50274414
Abdominal pain 233.97 14.61 722 313516 235506 50055380
Depressed level of consciousness 233.81 14.61 25 314213 51928 50238958
Wrong technique in product usage process 232.10 14.61 34 314204 55476 50235410
Atrial fibrillation 231.19 14.61 176 314062 101569 50189317
Blood cholesterol increased 226.14 14.61 806 313432 54409 50236477
Vision blurred 223.75 14.61 104 314134 78543 50212343
Stomatitis 222.83 14.61 1228 313010 100116 50190770
Fall 222.20 14.61 1198 313040 333734 49957152
Panniculitis 220.23 14.61 268 313970 8235 50282651
Gastrointestinal haemorrhage 219.61 14.61 90 314148 73231 50217655
Weight increased 216.28 14.61 2057 312181 199834 50091052
Rhabdomyolysis 214.24 14.61 6 314232 39021 50251865
Agitation 213.50 14.61 37 314201 53347 50237539
Gastrooesophageal reflux disease 212.93 14.61 104 314134 76324 50214562
Pulmonary embolism 212.44 14.61 191 314047 101513 50189373
Granuloma skin 210.02 14.61 218 314020 5600 50285286
Cerebrovascular accident 208.51 14.61 169 314069 94511 50196375
Pancytopenia 207.23 14.61 133 314105 83897 50206989
Blood parathyroid hormone decreased 207.05 14.61 238 314000 6876 50284010
Urinary tract infection 206.32 14.61 707 313531 223313 50067573
Coeliac disease 204.55 14.61 261 313977 8424 50282462
Sleep disorder 204.43 14.61 800 313438 56483 50234403
Arthritis 204.33 14.61 1071 313167 85650 50205236
Chest discomfort 201.10 14.61 168 314070 92554 50198332
Deformity 200.38 14.61 247 313991 7693 50283193
Metabolic acidosis 199.35 14.61 10 314228 38815 50252071
Paraesthesia 197.34 14.61 275 313963 119968 50170918
Cognitive disorder 194.10 14.61 23 314215 44100 50246786
Inappropriate schedule of product administration 193.74 14.61 102 314136 71729 50219157
Syncope 191.59 14.61 214 314024 102788 50188098
International normalised ratio increased 191.06 14.61 22 314216 43130 50247756
Swollen joint count increased 187.80 14.61 334 313904 14539 50276347
Hallucination 187.33 14.61 32 314206 46625 50244261
Dysphagia 186.68 14.61 126 314112 77392 50213494
Chest pain 185.61 14.61 526 313712 176356 50114530
Memory impairment 183.20 14.61 135 314103 79225 50211661
Cardiac failure 182.57 14.61 124 314114 75916 50214970
Ear pain 175.37 14.61 477 313761 27806 50263080
Lethargy 171.86 14.61 47 314191 49385 50241501
Joint destruction 167.68 14.61 161 314077 3755 50287131
Hyperglycaemia 165.14 14.61 17 314221 36388 50254498
Disability assessment scale score increased 164.18 14.61 128 314110 2230 50288656
Hypoxia 162.68 14.61 57 314181 51066 50239820
Chronic obstructive pulmonary disease 162.60 14.61 64 314174 53371 50237515
Lactic acidosis 161.00 14.61 12 314226 33343 50257543
Dysarthria 160.86 14.61 21 314217 37382 50253504
Platelet count decreased 160.67 14.61 235 314003 100491 50190395
Unresponsive to stimuli 160.01 14.61 7 314231 30602 50260284
Plasma cell myeloma 157.89 14.61 9 314229 31313 50259573
Disorientation 157.32 14.61 18 314220 35466 50255420
Musculoskeletal pain 154.20 14.61 868 313370 71309 50219577
Disturbance in attention 154.07 14.61 10 314228 31176 50259710
Suicidal ideation 153.30 14.61 76 314162 55309 50235577
Epistaxis 152.58 14.61 105 314133 63849 50227037
Therapeutic response decreased 152.10 14.61 639 313599 46592 50244294
Myalgia 151.02 14.61 343 313895 123976 50166910
Hospitalisation 148.65 14.61 122 314116 67815 50223071
Pleural effusion 148.45 14.61 172 314066 81282 50209604
Pulmonary fibrosis 148.38 14.61 409 313829 24028 50266858
Injection site erythema 147.95 14.61 148 314090 74788 50216098
Blood alkaline phosphatase increased 147.90 14.61 27 314211 37499 50253387
Blood glucose increased 147.66 14.61 135 314103 71189 50219697
Neoplasm progression 145.09 14.61 9 314229 29148 50261738
Deep vein thrombosis 144.47 14.61 145 314093 73159 50217727
No adverse event 144.21 14.61 498 313740 33080 50257806
Incorrect dose administered 144.03 14.61 60 314178 48354 50242532
Muscle spasticity 143.75 14.61 325 313913 16859 50274027
Mental status changes 143.16 14.61 26 314212 36246 50254640
Disease progression 143.01 14.61 234 314004 95632 50195254
Palpitations 142.55 14.61 229 314009 94277 50196609
Respiratory arrest 141.48 14.61 12 314226 29997 50260889
Psoriatic arthropathy 140.46 14.61 622 313616 46410 50244476
Skin necrosis 139.73 14.61 246 313992 10621 50280265
Sedation 139.61 14.61 14 314224 30596 50260290
Limb deformity 138.55 14.61 142 314096 3592 50287294
Drug tolerance decreased 137.23 14.61 222 314016 8938 50281948
Orthostatic hypotension 135.73 14.61 13 314225 29468 50261418
Neutropenia 135.41 14.61 468 313770 147497 50143389
Musculoskeletal deformity 134.92 14.61 81 314157 897 50289989
Diverticulitis 133.79 14.61 482 313756 32700 50258186
Hypophagia 133.76 14.61 10 314228 27718 50263168
Foot deformity 132.36 14.61 337 313901 18873 50272013
Fatigue 131.93 14.61 5505 308733 702096 49588790
Muscular weakness 131.63 14.61 243 313995 94770 50196116
Product quality issue 131.09 14.61 18 314220 30840 50260046
Dyskinesia 129.03 14.61 12 314226 27849 50263037
Bronchitis chronic 128.81 14.61 139 314099 3738 50287148
Blood potassium decreased 128.67 14.61 35 314203 36910 50253976
Generalised tonic-clonic seizure 128.32 14.61 9 314229 26301 50264585
Coronary artery disease 127.09 14.61 17 314221 29709 50261177
Sciatica 126.99 14.61 355 313883 21027 50269859
Skin exfoliation 126.55 14.61 27 314211 33585 50257301
Immobile 125.57 14.61 156 314082 4898 50285988
Pulmonary oedema 124.03 14.61 75 314163 48863 50242023
Emotional distress 123.48 14.61 16 314222 28647 50262239
Pneumonia 123.33 14.61 1633 312605 376768 49914118
Pneumonia aspiration 122.85 14.61 22 314216 30982 50259904
Osteonecrosis of jaw 122.72 14.61 26 314212 32500 50258386
Body temperature increased 121.92 14.61 450 313788 30891 50259995
Intentional self-injury 121.76 14.61 5 314233 23107 50267779
Tenosynovitis 121.67 14.61 228 314010 10337 50280549
Blood pressure systolic increased 121.54 14.61 489 313749 34960 50255926
Mucosal inflammation 120.62 14.61 49 314189 40093 50250793
Ascites 119.33 14.61 37 314201 35824 50255062
Intentional product misuse 117.92 14.61 72 314166 46662 50244224
Irritability 117.46 14.61 18 314220 28408 50262478
Depressed mood 117.05 14.61 33 314205 33990 50256896
Dysgeusia 116.13 14.61 48 314190 38868 50252018
Aggression 113.19 14.61 4 314234 21112 50269774
Toxic epidermal necrolysis 112.44 14.61 4 314234 20988 50269898
Blood bilirubin increased 112.23 14.61 30 314208 32008 50258878
Blood pressure diastolic abnormal 111.54 14.61 205 314033 9156 50281730
Immunodeficiency 111.52 14.61 269 313969 14559 50276327
Cough 110.92 14.61 961 313277 240303 50050583
Temperature regulation disorder 110.72 14.61 134 314104 4093 50286793
Hypervolaemia 110.41 14.61 14 314224 25485 50265401
Blood pressure systolic abnormal 110.36 14.61 183 314055 7523 50283363
Blood pressure diastolic decreased 110.06 14.61 289 313949 16492 50274394
Chills 110.06 14.61 276 313962 96411 50194475
Treatment noncompliance 109.93 14.61 26 314212 30124 50260762
Sepsis 109.47 14.61 439 313799 132486 50158400
Oral mucosal exfoliation 109.35 14.61 85 314153 1474 50289412
Liver function test increased 109.28 14.61 379 313859 25227 50265659
Dyspnoea exertional 108.40 14.61 95 314143 51138 50239748
Abnormal behaviour 107.97 14.61 3 314235 19655 50271231
Drug eruption 107.43 14.61 357 313881 23249 50267637
Body height below normal 106.72 14.61 92 314146 1857 50289029
Blood pressure decreased 106.31 14.61 114 314124 55795 50235091
Restlessness 106.19 14.61 15 314223 25158 50265728
Type 2 diabetes mellitus 105.97 14.61 459 313779 33916 50256970
Osteoarthritis 104.96 14.61 758 313480 67848 50223038
Psychotic disorder 104.84 14.61 8 314230 21804 50269082
Investigation abnormal 104.35 14.61 76 314162 1189 50289697
Accidental exposure to product 103.98 14.61 11 314227 23046 50267840
Joint laxity 103.45 14.61 99 314139 2299 50288587
Delirium 103.31 14.61 54 314184 38138 50252748
Dysuria 103.10 14.61 25 314213 28479 50262407
Bone pain 103.07 14.61 85 314153 47144 50243742
Foetal exposure during pregnancy 102.95 14.61 22 314216 27337 50263549
Flushing 102.35 14.61 161 314077 66854 50224032
Abdominal distension 102.26 14.61 185 314053 72718 50218168
Stevens-Johnson syndrome 101.72 14.61 9 314229 21743 50269143
Basal cell carcinoma 101.68 14.61 348 313890 23008 50267878
Blood calcium decreased 101.23 14.61 7 314231 20699 50270187
Pulmonary hypertension 100.07 14.61 41 314197 33376 50257510
Encephalopathy 99.91 14.61 42 314196 33669 50257217
Sinus tachycardia 99.41 14.61 9 314229 21345 50269541
Bone marrow failure 98.42 14.61 25 314213 27599 50263287
Blood sodium decreased 98.22 14.61 9 314229 21138 50269748
Aphasia 97.35 14.61 28 314210 28466 50262420
Fibromyalgia 96.75 14.61 542 313696 44436 50246450
Urinary retention 96.65 14.61 22 314216 26168 50264718
Pyrexia 94.90 14.61 1726 312512 378477 49912409
Pulmonary toxicity 94.73 14.61 143 314095 5419 50285467
Human antichimeric antibody positive 93.35 14.61 76 314162 1413 50289473
Rectal haemorrhage 92.37 14.61 63 314175 38495 50252391
Pneumonia viral 92.16 14.61 158 314080 6676 50284210
Red blood cell sedimentation rate 91.20 14.61 112 314126 3474 50287412
Blood urea increased 90.75 14.61 18 314220 23567 50267319
Jaundice 90.24 14.61 26 314212 26403 50264483
Presyncope 89.95 14.61 20 314218 24178 50266708
Drug reaction with eosinophilia and systemic symptoms 89.89 14.61 32 314206 28392 50262494
Haemorrhage 89.86 14.61 120 314118 53321 50237565
Haematuria 89.69 14.61 24 314214 25589 50265297
Product prescribing error 89.58 14.61 12 314226 20949 50269937
Hallucination, visual 89.38 14.61 3 314235 16579 50274307
Speech disorder 89.35 14.61 55 314183 35493 50255393
Accidental overdose 88.90 14.61 9 314229 19524 50271362
Physical disability 88.82 14.61 81 314157 1766 50289120
Chronic kidney disease 88.76 14.61 70 314168 39701 50251185
Respiratory distress 88.75 14.61 39 314199 30450 50260436
Hepatic failure 88.27 14.61 45 314193 32238 50258648
Arrhythmia 87.92 14.61 48 314190 33084 50257802
White blood cell count decreased 87.79 14.61 399 313839 116323 50174563
Joint range of motion decreased 86.96 14.61 283 313955 18229 50272657
Dry skin 86.74 14.61 84 314154 43107 50247779
Rheumatoid factor negative 86.17 14.61 51 314187 549 50290337
Pollakiuria 86.11 14.61 21 314217 23830 50267056
Acute myocardial infarction 85.91 14.61 37 314201 29236 50261650
Bone density decreased 84.45 14.61 202 314036 10873 50280013
Circulatory collapse 84.17 14.61 12 314226 19988 50270898
Altered state of consciousness 83.72 14.61 17 314221 21893 50268993
Caesarean section 83.69 14.61 3 314235 15636 50275250
Renal disorder 83.58 14.61 33 314205 27472 50263414
Full blood count decreased 82.01 14.61 19 314219 22327 50268559
Diabetic ketoacidosis 81.96 14.61 8 314230 17864 50273022
Haematochezia 81.92 14.61 76 314162 39806 50251080
Device issue 81.72 14.61 13 314225 19959 50270927
Ventricular tachycardia 81.45 14.61 4 314234 15817 50275069
Grip strength decreased 80.77 14.61 210 314028 11911 50278975
Thrombosis 80.73 14.61 139 314099 55694 50235192
Ejection fraction decreased 80.60 14.61 10 314228 18510 50272376
Withdrawal syndrome 80.33 14.61 8 314230 17582 50273304
Dry mouth 80.19 14.61 141 314097 56037 50234849
Metastases to bone 80.09 14.61 9 314229 17986 50272900
Hemiparesis 79.92 14.61 14 314224 20034 50270852
Haemophagocytic lymphohistiocytosis 79.83 14.61 170 314068 8463 50282423
Surgical failure 79.78 14.61 57 314181 864 50290022
Melaena 78.77 14.61 34 314204 26830 50264056
Angioedema 78.33 14.61 71 314167 37605 50253281
Mental disorder 78.16 14.61 20 314218 21971 50268915
Cholestasis 77.97 14.61 30 314208 25371 50265515
Wheezing 77.92 14.61 168 314070 61879 50229007
Blood creatine phosphokinase increased 77.90 14.61 33 314205 26334 50264552
Pericardial effusion 77.26 14.61 31 314207 25558 50265328
Spinal column injury 76.99 14.61 74 314164 1728 50289158
Unevaluable event 76.88 14.61 104 314134 45962 50244924
Blood pressure fluctuation 76.59 14.61 431 313807 35392 50255494
Toothache 76.43 14.61 255 313983 16639 50274247
Abortion spontaneous 76.31 14.61 88 314150 41684 50249202
Full blood count abnormal 76.27 14.61 25 314213 23363 50267523
Cardiomegaly 76.21 14.61 6 314232 15939 50274947
Malaise 76.08 14.61 1548 312690 333984 49956902
Vaginal haemorrhage 75.35 14.61 29 314209 24522 50266364
Transient ischaemic attack 75.34 14.61 54 314184 32156 50258730
Onychomycosis 75.26 14.61 122 314116 4920 50285966
Blood creatinine increased 75.08 14.61 233 314005 75927 50214959
Respiratory disorder 73.96 14.61 386 313852 30801 50260085
Colitis 73.87 14.61 78 314160 38451 50252435
Haematemesis 73.81 14.61 40 314198 27685 50263201
Ulcer 73.56 14.61 284 313954 19916 50270970
Acute respiratory failure 73.08 14.61 44 314194 28738 50262148
Electrolyte imbalance 72.96 14.61 10 314228 17159 50273727
Injection site pruritus 72.89 14.61 86 314152 40325 50250561
Gamma-glutamyltransferase increased 72.85 14.61 47 314191 29576 50261310
Food allergy 72.68 14.61 158 314080 7979 50282907
Myocardial infarction 72.65 14.61 295 313943 88732 50202154
Visual acuity reduced 72.18 14.61 18 314220 20121 50270765
Injection site swelling 72.08 14.61 92 314146 41681 50249205
Tubulointerstitial nephritis 71.93 14.61 6 314232 15205 50275681
Obstructive airways disorder 71.79 14.61 7 314231 15645 50275241
Nightmare 71.70 14.61 8 314230 16078 50274808
Blood pressure diastolic increased 71.65 14.61 149 314089 7294 50283592
Rash macular 71.52 14.61 16 314222 19261 50271625
Musculoskeletal disorder 70.77 14.61 253 313985 17096 50273790
Therapeutic response unexpected 70.73 14.61 8 314230 15907 50274979
Cerebral haemorrhage 70.61 14.61 40 314198 27012 50263874
Nervousness 70.59 14.61 42 314196 27609 50263277
Vertigo 70.49 14.61 134 314104 51698 50239188
Device dislocation 70.31 14.61 23 314215 21523 50269363
Haematocrit decreased 70.26 14.61 68 314170 34908 50255978
Hypersomnia 69.84 14.61 7 314231 15307 50275579
Staphylococcal infection 69.53 14.61 71 314167 35545 50255341
Joint injury 69.51 14.61 294 313944 21495 50269391
Atelectasis 68.12 14.61 15 314223 18255 50272631
Colitis microscopic 68.08 14.61 135 314103 6385 50284501
Pulmonary arterial hypertension 67.54 14.61 21 314217 20298 50270588
Pancreatitis 67.35 14.61 100 314138 42514 50248372
Blood lactate dehydrogenase increased 67.24 14.61 19 314219 19543 50271343
Arthrodesis 67.09 14.61 80 314158 2405 50288481
Vascular access complication 67.08 14.61 56 314182 1080 50289806
Feeling hot 66.95 14.61 87 314151 39115 50251771
Influenza like illness 66.95 14.61 162 314076 57297 50233589
COVID-19 66.70 14.61 117 314121 46545 50244341
Red cell distribution width decreased 66.34 14.61 55 314183 1050 50289836
Impaired work ability 66.32 14.61 211 314027 13429 50277457
Mean platelet volume decreased 65.61 14.61 65 314173 1577 50289309
Eating disorder 65.42 14.61 9 314229 15400 50275486
Small intestinal obstruction 64.53 14.61 11 314227 16057 50274829
Product administration error 64.33 14.61 21 314217 19678 50271208
Rheumatoid lung 64.33 14.61 78 314160 2387 50288499
Cardiac disorder 63.98 14.61 105 314133 42874 50248012
Infusion site pain 63.95 14.61 3 314235 12343 50278543
Blood glucose decreased 63.88 14.61 17 314221 18194 50272692
Epilepsy 63.70 14.61 27 314211 21540 50269346
Ataxia 63.67 14.61 6 314232 13780 50277106
Hyperhidrosis 63.53 14.61 312 313926 89114 50201772
Night sweats 63.42 14.61 391 313847 33183 50257703
Muscle twitching 63.23 14.61 10 314228 15421 50275465
Neutropenic sepsis 63.15 14.61 7 314231 14140 50276746
Bedridden 63.15 14.61 163 314075 9204 50281682
Lymphocyte count decreased 62.99 14.61 43 314195 26264 50264622
Loose body in joint 62.28 14.61 55 314183 1148 50289738
Diplopia 62.08 14.61 21 314217 19239 50271647
Demyelination 62.00 14.61 124 314114 5902 50284984
Urinary incontinence 61.26 14.61 51 314187 28157 50262729
Lip swelling 61.16 14.61 39 314199 24697 50266189
Osteoporotic fracture 61.03 14.61 86 314152 3059 50287827
Intestinal obstruction 60.70 14.61 45 314193 26338 50264548
Upper gastrointestinal haemorrhage 60.12 14.61 13 314225 16022 50274864
Exposure during pregnancy 60.09 14.61 472 313766 120543 50170343
Clostridium difficile colitis 59.57 14.61 18 314220 17724 50273162
Myelosuppression 59.56 14.61 7 314231 13510 50277376
Migraine 59.21 14.61 253 313985 75027 50215859
Heart rate decreased 59.15 14.61 409 313829 36088 50254798
Hypothermia 58.92 14.61 4 314234 12012 50278874
Haemoptysis 58.35 14.61 44 314194 25529 50265357
Tricuspid valve incompetence 57.82 14.61 6 314232 12764 50278122
Premature baby 57.38 14.61 21 314217 18316 50272570
Pharyngitis 57.26 14.61 238 314000 17265 50273621
Antibody test positive 56.88 14.61 71 314167 2240 50288646
Red blood cell count decreased 56.85 14.61 76 314162 33759 50257127
Eye swelling 56.71 14.61 27 314211 20117 50270769
Neutrophil count decreased 56.65 14.61 126 314112 45900 50244986
Oral herpes 56.58 14.61 267 313971 20458 50270428
Mitral valve incompetence 56.40 14.61 19 314219 17452 50273434
Tachypnoea 56.34 14.61 11 314227 14566 50276320
Sinus disorder 56.32 14.61 22 314216 18436 50272450
Acute hepatic failure 56.21 14.61 14 314224 15663 50275223
Anal incontinence 55.83 14.61 4 314234 11486 50279400
Dystonia 55.59 14.61 5 314233 11921 50278965
Adverse event 55.52 14.61 463 313775 43300 50247586
Pallor 55.44 14.61 38 314200 23161 50267725
Sinus bradycardia 55.27 14.61 8 314230 13175 50277711
Clostridium difficile infection 55.23 14.61 46 314192 25393 50265493
Device malfunction 55.20 14.61 13 314225 15108 50275778
Cutaneous vasculitis 55.12 14.61 98 314140 4264 50286622
Herpes zoster 55.05 14.61 677 313561 70109 50220777
Retinal toxicity 54.99 14.61 51 314187 1137 50289749
Frequent bowel movements 54.87 14.61 10 314228 13908 50276978
Multiple organ dysfunction syndrome 54.72 14.61 147 314091 50190 50240696
Infusion site reaction 54.66 14.61 68 314170 2138 50288748
Bursitis 54.59 14.61 277 313961 21858 50269028
Injection site mass 54.32 14.61 15 314223 15665 50275221
Contusion 54.01 14.61 988 313250 111195 50179691
Premature delivery 53.62 14.61 41 314197 23622 50267264
Cyanosis 53.60 14.61 14 314224 15170 50275716
Metastases to liver 53.52 14.61 29 314209 20075 50270811
Gastritis 53.50 14.61 76 314162 32907 50257979
Blood albumin decreased 53.29 14.61 9 314229 13227 50277659
Limb mass 53.17 14.61 74 314164 2601 50288285
Hyperlipidaemia 53.11 14.61 21 314217 17469 50273417
Mood altered 52.97 14.61 8 314230 12765 50278121
Flatulence 52.79 14.61 63 314175 29395 50261491
Injection site warmth 52.48 14.61 11 314227 13855 50277031
Mania 52.47 14.61 4 314234 10912 50279974
Dementia 52.34 14.61 17 314221 15980 50274906
Fear 52.15 14.61 13 314225 14536 50276350
Oesophagitis 51.94 14.61 10 314228 13373 50277513
Right ventricular failure 51.80 14.61 17 314221 15876 50275010
Anuria 51.65 14.61 5 314233 11239 50279647
Faeces discoloured 51.25 14.61 18 314220 16106 50274780
Blood magnesium decreased 51.16 14.61 5 314233 11155 50279731
Ageusia 51.03 14.61 6 314232 11577 50279309
Renal tubular necrosis 51.01 14.61 3 314235 10165 50280721
Finger deformity 50.37 14.61 110 314128 5572 50285314
Fine motor skill dysfunction 50.33 14.61 91 314147 4012 50286874
Cardiogenic shock 50.29 14.61 17 314221 15582 50275304
Disability 50.15 14.61 184 314054 12591 50278295
Face oedema 50.08 14.61 24 314214 17815 50273071
Systemic lupus erythematosus rash 49.87 14.61 58 314180 1697 50289189
Haematoma 49.78 14.61 70 314168 30440 50260446
Swelling face 49.67 14.61 164 314074 52431 50238455
Myelodysplastic syndrome 49.65 14.61 16 314222 15116 50275770
Presbyacusis 49.61 14.61 73 314165 2703 50288183
X-ray abnormal 49.22 14.61 71 314167 2581 50288305
Diverticular perforation 49.12 14.61 78 314160 3090 50287796
Joint arthroplasty 48.73 14.61 63 314175 2060 50288826
Polyarthritis 48.43 14.61 133 314105 7794 50283092
Transaminases abnormal 48.41 14.61 35 314203 541 50290345
Nodule 47.85 14.61 221 314017 16782 50274104
Delusion 47.76 14.61 5 314233 10564 50280322
Coagulopathy 47.60 14.61 26 314212 17918 50272968
Leukocytosis 47.59 14.61 42 314196 22537 50268349
Retching 47.07 14.61 11 314227 12851 50278035
Asthma 46.91 14.61 343 313895 88994 50201892
Myocardial ischaemia 46.53 14.61 8 314230 11605 50279281
Agranulocytosis 46.18 14.61 39 314199 21382 50269504
Acute myeloid leukaemia 45.94 14.61 18 314220 15056 50275830
Neurotoxicity 45.92 14.61 17 314221 14723 50276163
Multiple sclerosis 45.81 14.61 36 314202 20457 50270429
Premature labour 45.77 14.61 8 314230 11468 50279418
White blood cell count abnormal 45.62 14.61 103 314135 5337 50285549
Gastrointestinal perforation 45.60 14.61 74 314164 2987 50287899
Hypercholesterolaemia 45.47 14.61 168 314070 11535 50279351
Peptic ulcer haemorrhage 45.37 14.61 43 314195 986 50289900
Mean cell volume decreased 45.35 14.61 68 314170 2561 50288325
Weight decreased 45.34 14.61 1037 313201 220208 50070678
Oedema 45.27 14.61 253 313985 69928 50220958
Soft tissue disorder 44.90 14.61 88 314150 4126 50286760
Multiple fractures 44.52 14.61 115 314123 6496 50284390
Brain oedema 44.44 14.61 11 314227 12359 50278527
Macular degeneration 44.14 14.61 17 314221 14371 50276515
Hypovolaemia 44.03 14.61 4 314234 9461 50281425
Body temperature decreased 43.87 14.61 210 314028 16185 50274701
Hypokinesia 43.63 14.61 11 314227 12206 50278680
Progressive multifocal leukoencephalopathy 43.54 14.61 9 314229 11448 50279438
Abortion induced 43.33 14.61 4 314234 9340 50281546
Pleural thickening 43.10 14.61 66 314172 2533 50288353
Ventricular fibrillation 42.91 14.61 7 314231 10552 50280334
Aspiration 42.87 14.61 4 314234 9260 50281626
Glaucoma 42.76 14.61 202 314036 15484 50275402
Cholecystitis chronic 42.62 14.61 5 314233 9664 50281222
Glomerular filtration rate decreased 42.57 14.61 10 314228 11642 50279244
Lung infiltration 42.48 14.61 15 314223 13378 50277508
Iron deficiency anaemia 42.37 14.61 26 314212 16808 50274078
Hypocalcaemia 42.30 14.61 63 314175 26753 50264133
Cardiomyopathy 42.20 14.61 22 314216 15564 50275322
Urine output decreased 42.15 14.61 7 314231 10414 50280472
Hepatocellular injury 41.87 14.61 60 314178 25887 50264999
Renal injury 41.83 14.61 3 314235 8608 50282278
Joint effusion 41.77 14.61 176 314062 12845 50278041
Ankle arthroplasty 41.53 14.61 43 314195 1101 50289785
Pleural fibrosis 41.44 14.61 75 314163 3309 50287577
Eosinophilia 41.40 14.61 33 314205 18619 50272267
Eczema 41.27 14.61 48 314190 22654 50268232
Exostosis 40.94 14.61 162 314076 11491 50279395
Status epilepticus 40.87 14.61 16 314222 13390 50277496
Pancreatitis acute 40.50 14.61 53 314185 23759 50267127
Shock 40.49 14.61 41 314197 20609 50270277
Left ventricular dysfunction 40.46 14.61 8 314230 10498 50280388
Wheelchair user 40.43 14.61 93 314145 4879 50286007
Growth failure 39.59 14.61 25 314213 305 50290581
Dermatitis allergic 39.31 14.61 170 314068 12550 50278336
Complication associated with device 39.22 14.61 21 314217 14634 50276252
Malignant melanoma 39.19 14.61 145 314093 9963 50280923
Cold sweat 39.16 14.61 9 314229 10635 50280251
Hypotonia 39.04 14.61 3 314235 8131 50282755
Concomitant disease aggravated 38.79 14.61 3 314235 8088 50282798
Escherichia infection 38.78 14.61 10 314228 10931 50279955
Sleep apnoea syndrome 38.70 14.61 55 314183 23813 50267073
Subdural haematoma 38.57 14.61 16 314222 12931 50277955
Toxic skin eruption 38.54 14.61 11 314227 11240 50279646
Renal impairment 38.52 14.61 293 313945 75368 50215518
Acute generalised exanthematous pustulosis 38.47 14.61 5 314233 8933 50281953
Haemodynamic instability 38.40 14.61 3 314235 8021 50282865
Head injury 38.31 14.61 56 314182 23964 50266922
Injection site urticaria 38.21 14.61 14 314224 12203 50278683
Interstitial lung disease 38.12 14.61 501 313737 52675 50238211
Supraventricular tachycardia 37.85 14.61 16 314222 12785 50278101
Paranoia 37.57 14.61 9 314229 10339 50280547
Mean cell haemoglobin decreased 37.37 14.61 71 314167 3252 50287634
Anger 37.15 14.61 12 314226 11321 50279565
Device difficult to use 37.09 14.61 8 314230 9878 50281008
Hepatitis 36.86 14.61 327 313911 31126 50259760
Oliguria 36.84 14.61 4 314234 8212 50282674
Sensory loss 36.73 14.61 3 314235 7735 50283151
Blood calcium increased 36.62 14.61 3 314235 7716 50283170
Nail disorder 36.59 14.61 138 314100 9570 50281316
Vasculitic rash 36.54 14.61 42 314196 1213 50289673
Aplastic anaemia 36.53 14.61 3 314235 7700 50283186
Device related infection 36.46 14.61 45 314193 20690 50270196
Localised infection 36.35 14.61 277 313961 25208 50265678
Posterior reversible encephalopathy syndrome 36.27 14.61 24 314214 14904 50275982
Hypercalcaemia 36.26 14.61 259 313979 23093 50267793
Blood pressure abnormal 36.01 14.61 17 314221 12730 50278156
Haemolytic anaemia 35.94 14.61 7 314231 9285 50281601
Incorrect product administration duration 35.85 14.61 7 314231 9268 50281618
Drug specific antibody 35.55 14.61 50 314188 1775 50289111
Infiltration anaesthesia 35.24 14.61 18 314220 141 50290745
Joint dislocation 35.22 14.61 161 314077 12172 50278714
Atrial flutter 35.19 14.61 6 314232 8757 50282129
Malnutrition 35.15 14.61 19 314219 13170 50277716
Myopathy 35.10 14.61 7 314231 9132 50281754
Infusion site erythema 34.99 14.61 6 314232 8721 50282165
Hysterectomy 34.98 14.61 4 314234 7886 50283000
Arthritis bacterial 34.95 14.61 95 314143 5534 50285352
Pulmonary mass 34.79 14.61 217 314021 18488 50272398
Schizophrenia 34.75 14.61 3 314235 7394 50283492
Ventricular extrasystoles 34.71 14.61 11 314227 10505 50280381
Feeling jittery 34.55 14.61 13 314225 11147 50279739
Deafness 34.53 14.61 28 314210 15663 50275223
Blood magnesium increased 34.22 14.61 63 314175 2817 50288069
Panic attack 33.99 14.61 42 314196 19300 50271586
Ileus 33.90 14.61 20 314218 13209 50277677
Metastases to lung 33.84 14.61 13 314225 11007 50279879
Oral candidiasis 33.84 14.61 33 314205 16882 50274004
Rash papular 33.82 14.61 18 314220 12586 50278300
Viral upper respiratory tract infection 33.80 14.61 108 314130 6888 50283998
Ocular hyperaemia 33.66 14.61 46 314192 20246 50270640
Intercepted product storage error 33.40 14.61 12 314226 33 50290853
Flank pain 33.36 14.61 20 314218 13095 50277791
Device breakage 33.32 14.61 9 314229 9538 50281348
Mesenteritis 33.20 14.61 17 314221 134 50290752
Central nervous system lesion 33.02 14.61 9 314229 9480 50281406
Therapy non-responder 32.62 14.61 471 313767 50551 50240335
Hypoaesthesia oral 32.38 14.61 13 314225 10715 50280171
Skin papilloma 32.10 14.61 77 314161 4152 50286734
Hemiplegia 32.08 14.61 4 314234 7377 50283509
Ischaemic stroke 32.03 14.61 31 314207 15917 50274969
Torus fracture 32.02 14.61 16 314222 119 50290767
Pruritus allergic 31.80 14.61 37 314201 1083 50289803
Haemorrhoids 31.80 14.61 43 314195 19010 50271876
Extremity contracture 31.77 14.61 39 314199 1209 50289677
Osteonecrosis 31.69 14.61 57 314181 22460 50268426
Anti-cyclic citrullinated peptide antibody 31.58 14.61 44 314194 1548 50289338
Drug resistance 31.55 14.61 43 314195 18946 50271940
Adverse drug reaction 31.52 14.61 500 313738 54722 50236164
Ankylosing spondylitis 31.39 14.61 107 314131 7058 50283828
Nephropathy toxic 31.16 14.61 6 314232 8023 50282863
Chromaturia 30.92 14.61 27 314211 14563 50276323
Hot flush 30.84 14.61 155 314083 44014 50246872
Femur fracture 30.73 14.61 362 313876 37102 50253784
Taste disorder 30.70 14.61 7 314231 8317 50282569
Apathy 30.68 14.61 5 314233 7543 50283343
Breast cancer metastatic 30.57 14.61 13 314225 10351 50280535
Paralysis 30.56 14.61 8 314230 8656 50282230
Autoimmune hepatitis 30.52 14.61 5 314233 7514 50283372
Illness 30.34 14.61 67 314171 24473 50266413
Skin discolouration 30.33 14.61 103 314135 32654 50258232
Hip fracture 30.29 14.61 73 314165 25858 50265028
Rales 30.27 14.61 12 314226 9966 50280920
Hypoacusis 30.21 14.61 51 314187 20596 50270290
Peripheral sensory neuropathy 30.09 14.61 3 314235 6588 50284298
Tumour lysis syndrome 29.98 14.61 5 314233 7416 50283470
Injection site bruising 29.88 14.61 122 314116 36646 50254240
Drug level decreased 29.76 14.61 3 314235 6530 50284356
Underdose 29.75 14.61 50 314188 20228 50270658
Injection site rash 29.63 14.61 34 314204 16143 50274743
Pulmonary haemorrhage 29.52 14.61 3 314235 6489 50284397
Pruritus 29.36 14.61 2091 312147 281477 50009409
Paraesthesia oral 29.22 14.61 20 314218 12201 50278685
Pre-eclampsia 29.20 14.61 7 314231 8037 50282849
Motor dysfunction 29.13 14.61 7 314231 8024 50282862
Liver injury 29.12 14.61 258 313980 24548 50266338
Arteriosclerosis 29.08 14.61 10 314228 9067 50281819
Deafness neurosensory 28.99 14.61 77 314161 4424 50286462
Glycosylated haemoglobin increased 28.67 14.61 15 314223 10591 50280295
Dermatitis contact 28.62 14.61 9 314229 8637 50282249
Onychomadesis 28.60 14.61 66 314172 3470 50287416
Bipolar disorder 28.56 14.61 4 314234 6753 50284133
Cholelithiasis 28.41 14.61 130 314108 37843 50253043
Cardiac failure acute 28.38 14.61 8 314230 8242 50282644
Eructation 28.32 14.61 5 314233 7116 50283770
Polyuria 28.32 14.61 5 314233 7116 50283770
Skin burning sensation 28.14 14.61 14 314224 10171 50280715
Hypoalbuminaemia 28.09 14.61 13 314225 9847 50281039
Bundle branch block left 28.02 14.61 3 314235 6227 50284659
Hypoaesthesia 27.89 14.61 590 313648 126667 50164219
Productive cough 27.80 14.61 202 314036 52492 50238394
Eyelid ptosis 27.77 14.61 3 314235 6184 50284702
Gallbladder disorder 27.72 14.61 38 314200 16704 50274182
Eyelid oedema 27.72 14.61 12 314226 9454 50281432
Troponin increased 27.69 14.61 8 314230 8110 50282776
Mood swings 27.66 14.61 35 314203 15919 50274967
Graft versus host disease 27.65 14.61 3 314235 6163 50284723
Thrombotic microangiopathy 27.62 14.61 10 314228 8781 50282105
Genital haemorrhage 27.53 14.61 4 314234 6570 50284316
Pelvic pain 27.28 14.61 18 314220 11195 50279691
Intestinal sepsis 27.27 14.61 18 314220 238 50290648
Liver disorder 27.22 14.61 352 313886 36870 50254016
Heavy menstrual bleeding 27.02 14.61 34 314204 15503 50275383
Major depression 27.02 14.61 5 314233 6879 50284007
Juvenile idiopathic arthritis 26.97 14.61 57 314181 2822 50288064
Electrocardiogram abnormal 26.86 14.61 7 314231 7598 50283288
Device occlusion 26.83 14.61 3 314235 6020 50284866
Pain of skin 26.80 14.61 8 314230 7939 50282947
Lymphadenopathy 26.69 14.61 112 314126 33387 50257499
Injection site haemorrhage 26.62 14.61 58 314180 21288 50269598
Prosthesis user 26.57 14.61 12 314226 69 50290817
Throat tightness 26.54 14.61 56 314182 20791 50270095
Intestinal perforation 26.45 14.61 132 314106 10347 50280539
Skin plaque 26.16 14.61 4 314234 6324 50284562
Injection site hypersensitivity 26.11 14.61 43 314195 1757 50289129
Dysstasia 26.08 14.61 44 314194 17775 50273111
Thirst 26.04 14.61 17 314221 10633 50280253
Loss of consciousness 25.83 14.61 474 313764 103879 50187007
Back pain 25.81 14.61 1110 313128 218920 50071966
Metastases to lymph nodes 25.72 14.61 6 314232 7018 50283868
Cytomegalovirus infection 25.70 14.61 45 314193 17917 50272969
Tinnitus 25.68 14.61 89 314149 28043 50262843
Vitamin D deficiency 25.52 14.61 20 314218 11382 50279504
Hepatic encephalopathy 25.50 14.61 14 314224 9622 50281264
Erythema 25.44 14.61 703 313535 145711 50145175
Accident 25.42 14.61 80 314158 5061 50285825
Hospice care 25.40 14.61 3 314235 5769 50285117
Hiatus hernia 25.31 14.61 47 314191 18297 50272589
Enthesopathy 25.27 14.61 100 314138 7093 50283793
White blood cell count increased 25.25 14.61 156 314082 42084 50248802
Orthopnoea 24.93 14.61 3 314235 5686 50285200
Personality change 24.68 14.61 3 314235 5642 50285244
Diabetic eye disease 24.53 14.61 14 314224 140 50290746
Pseudomonas infection 24.53 14.61 14 314224 9416 50281470
Brachiocephalic artery stenosis 24.48 14.61 9 314229 27 50290859
Amenorrhoea 24.46 14.61 11 314227 8473 50282413
Activated partial thromboplastin time prolonged 24.39 14.61 5 314233 6397 50284489
Nystagmus 24.20 14.61 3 314235 5558 50285328
Atrial septal defect 24.06 14.61 5 314233 6336 50284550
Middle insomnia 24.04 14.61 16 314222 9905 50280981
Angina unstable 24.02 14.61 6 314232 6700 50284186
Congestive cardiomyopathy 23.96 14.61 3 314235 5515 50285371
Polyneuropathy 23.88 14.61 24 314214 12107 50278779
Shock haemorrhagic 23.77 14.61 11 314227 8333 50282553
Thinking abnormal 23.77 14.61 15 314223 9552 50281334
Hyperthermia 23.77 14.61 9 314229 7687 50283199
Wrist surgery 23.73 14.61 27 314211 771 50290115
Laboratory test abnormal 23.57 14.61 70 314168 23138 50267748
Arteriosclerosis coronary artery 23.46 14.61 9 314229 7627 50283259
Amylase increased 23.46 14.61 3 314235 5427 50285459
Amyotrophic lateral sclerosis 23.46 14.61 31 314207 1036 50289850
Drug tolerance 23.30 14.61 76 314162 4900 50285986
Acute pulmonary oedema 23.29 14.61 8 314230 7259 50283627
Second primary malignancy 23.24 14.61 7 314231 6907 50283979
Expired product administered 23.19 14.61 3 314235 5379 50285507
Aortic arteriosclerosis 23.19 14.61 3 314235 5379 50285507
Stress cardiomyopathy 23.09 14.61 10 314228 7877 50283009
Dizziness postural 23.00 14.61 5 314233 6140 50284746
Pulseless electrical activity 22.86 14.61 7 314231 6834 50284052
Splenomegaly 22.84 14.61 16 314222 9644 50281242
Hepatomegaly 22.84 14.61 20 314218 10773 50280113
Atrioventricular block 22.81 14.61 6 314232 6472 50284414
Erythema multiforme 22.74 14.61 14 314224 9036 50281850
Gestational diabetes 22.61 14.61 9 314229 7456 50283430
Rash maculo-papular 22.53 14.61 87 314151 26554 50264332
Injection site induration 22.52 14.61 12 314226 8385 50282501
Bone cyst 22.46 14.61 43 314195 1981 50288905
Oral discomfort 22.41 14.61 104 314134 7913 50282973
Therapy change 22.30 14.61 3 314235 5222 50285664
Product complaint 22.21 14.61 23 314215 11443 50279443
Dislocation of vertebra 22.14 14.61 55 314183 3032 50287854
Impaired gastric emptying 22.13 14.61 110 314128 8608 50282278
Eye pain 22.12 14.61 96 314142 28353 50262533
Lower limb fracture 22.11 14.61 158 314080 14088 50276798
Rhinorrhoea 22.10 14.61 209 314029 51374 50239512
Obesity 22.09 14.61 179 314059 16596 50274290
Feeding disorder 22.06 14.61 20 314218 10593 50280293
Nasal congestion 21.95 14.61 207 314031 50913 50239973
Eye irritation 21.85 14.61 46 314192 17094 50273792
Poor quality sleep 21.79 14.61 44 314194 16602 50274284
Injection site reaction 21.78 14.61 434 313804 49598 50241288
Device failure 21.73 14.61 4 314234 5524 50285362
Initial insomnia 21.68 14.61 3 314235 5112 50285774
Immune reconstitution inflammatory syndrome 21.66 14.61 4 314234 5512 50285374
Respiration abnormal 21.61 14.61 3 314235 5099 50285787
Tooth infection 21.61 14.61 156 314082 13956 50276930
Acidosis 21.58 14.61 19 314219 10208 50280678
Product label confusion 21.52 14.61 21 314217 500 50290386
Extra dose administered 21.47 14.61 3 314235 5073 50285813
Respiratory tract infection 21.42 14.61 114 314124 31903 50258983
Purpura 21.42 14.61 18 314220 9893 50280993
Skin reaction 21.39 14.61 134 314104 11434 50279452
Odynophagia 21.27 14.61 7 314231 6525 50284361
Eye pruritus 21.21 14.61 28 314210 12506 50278380
Angina pectoris 21.21 14.61 87 314151 26101 50264785
Coronary artery occlusion 21.21 14.61 10 314228 7493 50283393
Abdominal pain lower 21.12 14.61 67 314171 21689 50269197
Hyperventilation 21.08 14.61 4 314234 5405 50285481
Intermenstrual bleeding 20.99 14.61 8 314230 6806 50284080
Toe amputation 20.98 14.61 40 314198 1837 50289049
Hepatitis cholestatic 20.91 14.61 6 314232 6111 50284775
Amnesia 20.87 14.61 165 314073 42095 50248791
Swollen tongue 20.83 14.61 99 314139 28531 50262355
Hyperthyroidism 20.81 14.61 27 314211 12148 50278738
Blood thyroid stimulating hormone increased 20.78 14.61 6 314232 6086 50284800
Wrist deformity 20.78 14.61 39 314199 1770 50289116
Rheumatoid vasculitis 20.75 14.61 17 314221 319 50290567
Lymphopenia 20.70 14.61 41 314197 15580 50275306
Drug dependence 20.50 14.61 59 314179 19700 50271186
Sensory disturbance 20.46 14.61 26 314212 11803 50279083
Metabolic disorder 20.41 14.61 4 314234 5282 50285604
Lipase increased 20.39 14.61 14 314224 8527 50282359
Normal newborn 20.37 14.61 8 314230 6683 50284203
Partial seizures 20.28 14.61 3 314235 4862 50286024
Monocyte count increased 20.26 14.61 78 314160 5461 50285425
Adverse reaction 20.16 14.61 106 314132 8480 50282406
Vaginal discharge 20.16 14.61 4 314234 5236 50285650
Foetal death 20.08 14.61 13 314225 8167 50282719
Generalised oedema 20.01 14.61 34 314204 13697 50277189
Restless legs syndrome 19.99 14.61 43 314195 15854 50275032
Onychoclasis 19.92 14.61 4 314234 5192 50285694
Hypovolaemic shock 19.87 14.61 4 314234 5184 50285702
Urine abnormality 19.76 14.61 7 314231 6231 50284655
Photosensitivity reaction 19.72 14.61 31 314207 12880 50278006
Sputum discoloured 19.67 14.61 33 314205 13362 50277524
Pharyngeal abscess 19.55 14.61 15 314223 255 50290631
Crohn's disease 19.55 14.61 3 314235 4730 50286156
Body height decreased 19.47 14.61 16 314222 8892 50281994
Androgenetic alopecia 19.46 14.61 12 314226 140 50290746
Epigastric discomfort 19.34 14.61 80 314158 5790 50285096
Urticaria 19.34 14.61 987 313251 128574 50162312
Neck surgery 19.29 14.61 34 314204 1469 50289417
Infected skin ulcer 19.26 14.61 41 314197 2040 50288846
Asphyxia 19.16 14.61 5 314233 5422 50285464
Refusal of treatment by patient 19.14 14.61 4 314234 5049 50285837
Micturition urgency 19.13 14.61 14 314224 8250 50282636
Tongue disorder 19.11 14.61 110 314128 9106 50281780
Pancreatic toxicity 19.04 14.61 7 314231 21 50290865
Bacteraemia 19.02 14.61 38 314200 14395 50276491
Salt craving 18.89 14.61 10 314228 85 50290801
Proctalgia 18.87 14.61 4 314234 4999 50285887
Hepatic function abnormal 18.86 14.61 122 314116 32559 50258327
Oesophageal candidiasis 18.82 14.61 4 314234 4990 50285896
Rib fracture 18.79 14.61 59 314179 19162 50271724
Cholecystectomy 18.78 14.61 18 314220 9285 50281601
Tendon disorder 18.70 14.61 74 314164 5248 50285638
Blood glucose abnormal 18.69 14.61 9 314229 6663 50284223
Haemolysis 18.64 14.61 7 314231 6009 50284877
Product use in unapproved indication 18.63 14.61 562 313676 115257 50175629
Embolism 18.62 14.61 10 314228 6958 50283928
Jaw disorder 18.54 14.61 4 314234 4939 50285947
Secretion discharge 18.47 14.61 114 314124 9677 50281209
Live birth 18.41 14.61 169 314069 16239 50274647
Intervertebral disc compression 18.40 14.61 26 314212 927 50289959
Rhinitis allergic 18.29 14.61 11 314227 7189 50283697
Protein total decreased 18.26 14.61 5 314233 5251 50285635
Klebsiella infection 18.26 14.61 11 314227 7183 50283703
Blood disorder 18.26 14.61 6 314232 5599 50285287
Head discomfort 18.26 14.61 25 314213 10994 50279892
Lower gastrointestinal haemorrhage 18.20 14.61 10 314228 6869 50284017
Neutrophil count increased 18.18 14.61 38 314200 14157 50276729
Exercise tolerance decreased 18.17 14.61 4 314234 4870 50286016
Herpes simplex 18.11 14.61 11 314227 7151 50283735
Cerebral ischaemia 18.09 14.61 7 314231 5901 50284985
Cerebral infarction 17.98 14.61 71 314167 21533 50269353
Multiple system atrophy 17.98 14.61 13 314225 201 50290685
Acute coronary syndrome 17.94 14.61 19 314219 9355 50281531
Decreased activity 17.90 14.61 5 314233 5182 50285704
Iron deficiency 17.86 14.61 7 314231 5855 50285031
Faecaloma 17.86 14.61 11 314227 7097 50283789
Squamous cell carcinoma of skin 17.85 14.61 5 314233 5173 50285713
Heart rate irregular 17.84 14.61 61 314177 19299 50271587
Abscess rupture 17.81 14.61 14 314224 247 50290639
Procedural pain 17.74 14.61 37 314201 13795 50277091
Gastropleural fistula 17.71 14.61 8 314230 46 50290840
Spinal cord infection 17.69 14.61 20 314218 567 50290319
Hyperbilirubinaemia 17.65 14.61 20 314218 9550 50281336
Pain in jaw 17.63 14.61 153 314085 38275 50252611
Vaginal haematoma 17.57 14.61 11 314227 132 50290754
Metastasis 17.56 14.61 3 314235 4372 50286514
Ear discomfort 17.56 14.61 10 314228 6734 50284152
Emotional disorder 17.53 14.61 29 314209 11807 50279079
Large intestine polyp 17.53 14.61 12 314226 7320 50283566
Hereditary angioedema 17.42 14.61 6 314232 5436 50285450
Rheumatic disorder 17.39 14.61 33 314205 1510 50289376
Blood loss anaemia 17.32 14.61 15 314223 8124 50282762
Intervertebral disc space narrowing 17.27 14.61 25 314213 912 50289974
Post procedural haemorrhage 17.25 14.61 12 314226 7258 50283628
Protein urine present 17.09 14.61 6 314232 5371 50285515
Increased appetite 17.09 14.61 16 314222 8345 50282541
Gait inability 17.07 14.61 324 313914 36703 50254183
Gastric haemorrhage 17.03 14.61 7 314231 5689 50285197
Spinal osteoarthritis 16.99 14.61 39 314199 14053 50276833
Viral infection 16.77 14.61 113 314125 29873 50261013
Candida infection 16.73 14.61 82 314156 23441 50267445
Lacrimation increased 16.72 14.61 52 314186 16940 50273946
Drug-induced liver injury 16.67 14.61 104 314134 27991 50262895
Skin hyperpigmentation 16.58 14.61 6 314232 5270 50285616
Abnormal faeces 16.57 14.61 3 314235 4193 50286693
Disability assessment scale score decreased 16.53 14.61 5 314233 6 50290880
Acute respiratory distress syndrome 16.53 14.61 71 314167 21028 50269858
Lower respiratory tract congestion 16.46 14.61 38 314200 1998 50288888
Alanine aminotransferase abnormal 16.43 14.61 60 314178 4096 50286790
Sleep disorder due to a general medical condition 16.41 14.61 13 314225 7358 50283528
Low birth weight baby 16.37 14.61 8 314230 5873 50285013
Sudden death 16.35 14.61 19 314219 8972 50281914
Normochromic normocytic anaemia 16.30 14.61 3 314235 4143 50286743
Gastric disorder 16.28 14.61 266 313972 29282 50261604
Tooth loss 16.28 14.61 9 314229 6161 50284725
Bunion operation 16.28 14.61 27 314211 1110 50289776
Neuralgia 16.26 14.61 75 314163 21788 50269098
Infected bite 16.24 14.61 30 314208 1345 50289541
Localised oedema 16.23 14.61 5 314233 4862 50286024
Disseminated large cell lymphoma 16.18 14.61 8 314230 58 50290828
Affective disorder 16.10 14.61 6 314232 5175 50285711
Hypothyroidism 16.05 14.61 135 314103 33990 50256896
Synovial cyst 15.99 14.61 96 314142 8070 50282816
Needle issue 15.98 14.61 13 314225 7262 50283624
Adenoiditis 15.98 14.61 7 314231 37 50290849
Dermatitis exfoliative 15.90 14.61 6 314232 5136 50285750
Blood urine present 15.89 14.61 35 314203 12798 50278088
Escherichia urinary tract infection 15.84 14.61 25 314213 10370 50280516
Dermatitis acneiform 15.81 14.61 3 314235 4054 50286832
Mouth ulceration 15.71 14.61 253 313985 27771 50263115
Eosinophil count increased 15.70 14.61 19 314219 8811 50282075
Pulmonary alveolar haemorrhage 15.65 14.61 3 314235 4024 50286862
Epstein-Barr viraemia 15.60 14.61 23 314215 853 50290033
Mental fatigue 15.54 14.61 15 314223 352 50290534
Azotaemia 15.54 14.61 3 314235 4005 50286881
Dermatitis bullous 15.53 14.61 13 314225 7160 50283726
Pleurisy 15.53 14.61 88 314150 7243 50283643
Immune thrombocytopenia 15.41 14.61 20 314218 8997 50281889
Hypofibrinogenaemia 15.38 14.61 26 314212 1086 50289800
Effusion 15.32 14.61 32 314206 1571 50289315
Heparin-induced thrombocytopenia 15.31 14.61 3 314235 3962 50286924
Movement disorder 15.29 14.61 57 314181 17575 50273311
Periorbital oedema 15.25 14.61 6 314232 5006 50285880
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.23 14.61 40 314198 2282 50288604
Myositis 15.22 14.61 16 314222 7904 50282982
Pneumonia fungal 15.21 14.61 4 314234 4316 50286570
Gastric infection 15.20 14.61 47 314191 2945 50287941
Post-traumatic stress disorder 15.12 14.61 4 314234 4299 50286587
Anosmia 15.12 14.61 3 314235 3928 50286958
Wound infection 15.12 14.61 128 314110 12020 50278866
Bundle branch block right 15.08 14.61 5 314233 4640 50286246
Coronary artery stenosis 15.05 14.61 4 314234 4285 50286601
Intercepted medication error 15.04 14.61 16 314222 423 50290463
Peroneal nerve palsy 15.02 14.61 4 314234 4279 50286607
Aphthous ulcer 15.01 14.61 115 314123 10482 50280404
Nephropathy 14.87 14.61 7 314231 5251 50285635
Sexual abuse 14.85 14.61 10 314228 137 50290749
Fluid retention 14.85 14.61 223 314015 50426 50240460
Breast mass 14.83 14.61 11 314227 6438 50284448
Proteinuria 14.82 14.61 53 314185 16544 50274342
Petechiae 14.79 14.61 35 314203 12477 50278409
Hepatitis C 14.77 14.61 6 314232 4911 50285975
Retinal haemorrhage 14.75 14.61 5 314233 4576 50286310
Premature rupture of membranes 14.75 14.61 5 314233 4575 50286311
Fracture delayed union 14.72 14.61 39 314199 2237 50288649
Breath sounds abnormal 14.68 14.61 16 314222 7776 50283110
Infusion site extravasation 14.67 14.61 13 314225 6963 50283923
Aplasia pure red cell 14.66 14.61 4 314234 4211 50286675

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1668.62 14.64 2620 51667 360550 29159690
Off label use 1603.69 14.64 2328 51959 298472 29221768
Joint swelling 1033.87 14.64 800 53487 48830 29471410
Intentional product use issue 869.39 14.64 678 53609 41820 29478420
Contraindicated product administered 771.99 14.64 457 53830 17809 29502431
Synovitis 742.61 14.64 374 53913 10516 29509724
Rheumatoid arthritis 637.79 14.64 504 53783 31648 29488592
Apparent death 563.97 14.64 220 54067 3284 29516956
Treatment failure 532.74 14.64 482 53805 36457 29483783
Bone erosion 511.29 14.64 192 54095 2568 29517672
Diverticulitis 505.79 14.64 346 53941 17358 29502882
Drug intolerance 420.15 14.64 480 53807 47899 29472341
Arthropathy 403.96 14.64 327 53960 21227 29499013
Therapeutic product effect decreased 396.64 14.64 370 53917 29081 29491159
C-reactive protein abnormal 386.36 14.64 204 54083 6332 29513908
No adverse event 370.16 14.64 285 54002 17193 29503047
Red blood cell sedimentation rate abnormal 336.98 14.64 135 54152 2168 29518072
Arthralgia 334.71 14.64 769 53518 138848 29381392
Drug eruption 317.90 14.64 256 54031 16485 29503755
Pain 302.99 14.64 841 53446 170591 29349649
Stomatitis 275.39 14.64 340 53947 36773 29483467
Urticaria 264.13 14.64 407 53880 54253 29465987
Toxicity to various agents 258.78 14.64 15 54272 173646 29346594
Red blood cell sedimentation rate increased 222.90 14.64 150 54137 7311 29512929
Hypersensitivity 212.08 14.64 362 53925 52541 29467699
Hepatic function abnormal 206.16 14.64 304 53983 38955 29481285
Pain in extremity 197.80 14.64 545 53742 109888 29410352
Drug hypersensitivity 186.24 14.64 397 53890 68009 29452231
Rheumatoid factor negative 176.78 14.64 64 54223 766 29519474
Peripheral swelling 174.74 14.64 371 53916 63368 29456872
Diarrhoea 168.53 14.64 219 54068 332479 29187761
Loss of personal independence in daily activities 167.96 14.64 220 54067 25220 29495020
Pulmonary thrombosis 165.67 14.64 119 54168 6446 29513794
Musculoskeletal stiffness 164.35 14.64 267 54020 37191 29483049
Ill-defined disorder 159.54 14.64 148 54139 11530 29508710
C-reactive protein increased 153.04 14.64 284 54003 43979 29476261
Knee arthroplasty 152.81 14.64 108 54179 5701 29514539
Anaemia 147.05 14.64 94 54193 200857 29319383
Completed suicide 147.00 14.64 4 54283 90242 29429998
Bone cyst 144.15 14.64 50 54237 523 29519717
Mobility decreased 137.25 14.64 201 54086 25579 29494661
Impaired work ability 132.70 14.64 98 54189 5542 29514698
Terminal state 128.35 14.64 80 54207 3414 29516826
Overdose 124.81 14.64 5 54282 79814 29440426
Swelling 122.71 14.64 227 54060 35056 29485184
Arthritis bacterial 120.62 14.64 84 54203 4329 29515911
Anti-cyclic citrullinated peptide antibody positive 119.49 14.64 48 54239 776 29519464
Acute kidney injury 116.12 14.64 193 54094 265074 29255166
Epistaxis 115.99 14.64 278 54009 51426 29468814
Drug specific antibody present 115.75 14.64 67 54220 2494 29517746
Febrile neutropenia 114.72 14.64 32 54255 112208 29408032
Fatigue 111.60 14.64 262 54025 316559 29203681
Mass 110.67 14.64 97 54190 7014 29513226
Interstitial lung disease 108.27 14.64 290 53997 57428 29462812
Vomiting 107.94 14.64 139 54148 212121 29308119
Deep vein thrombosis 106.27 14.64 287 54000 57112 29463128
Confusional state 106.19 14.64 51 54236 127826 29392414
Haemophagocytic lymphohistiocytosis 106.18 14.64 113 54174 10391 29509849
Dehydration 104.45 14.64 40 54247 114708 29405532
Herpes zoster 104.05 14.64 193 54094 29859 29490381
Drug interaction 103.75 14.64 126 54161 197259 29322981
Skin ulcer 103.33 14.64 149 54138 18691 29501549
Infusion related reaction 101.70 14.64 239 54048 43647 29476593
Pulmonary embolism 99.59 14.64 338 53949 76196 29444044
Limb discomfort 98.61 14.64 104 54183 9464 29510776
Hypofibrinogenaemia 97.70 14.64 50 54237 1451 29518789
Joint ankylosis 95.44 14.64 34 54253 387 29519853
Bladder transitional cell carcinoma 92.04 14.64 57 54230 2404 29517836
Intestinal polyp 88.72 14.64 40 54247 870 29519370
Gastric disorder 85.70 14.64 102 54185 10602 29509638
Malignant neoplasm progression 83.41 14.64 17 54270 73842 29446398
Joint lock 83.36 14.64 41 54246 1091 29519149
Nasopharyngitis 80.68 14.64 267 54020 59398 29460842
Death 80.12 14.64 340 53947 341744 29178496
Nodule 80.09 14.64 70 54217 5042 29515198
X-ray abnormal 76.84 14.64 30 54257 448 29519792
Cytology abnormal 74.69 14.64 28 54259 372 29519868
Physical disability 73.68 14.64 39 54248 1215 29519025
Sleep disorder due to general medical condition, insomnia type 72.98 14.64 39 54248 1239 29519001
Pyrexia 72.23 14.64 278 54009 287344 29232896
Dyspnoea 71.48 14.64 333 53954 326399 29193841
Blood pressure diastolic abnormal 70.75 14.64 49 54238 2502 29517738
Dizziness 70.56 14.64 152 54135 189532 29330708
Joint arthroplasty 70.01 14.64 31 54256 645 29519595
Arthritis 68.88 14.64 146 54141 24873 29495367
Asthenia 68.63 14.64 187 54100 215063 29305177
Drug use disorder 68.48 14.64 54 54233 3368 29516872
Hepatitis B virus test positive 68.11 14.64 24 54263 264 29519976
Hyponatraemia 67.73 14.64 20 54267 67613 29452627
Cardiac failure congestive 65.91 14.64 29 54258 76552 29443688
Polyarthritis 65.81 14.64 56 54231 3889 29516351
Constipation 65.21 14.64 68 54219 114092 29406148
Hepatitis 65.17 14.64 128 54159 20655 29499585
Decreased appetite 65.06 14.64 104 54183 145238 29375002
Rheumatoid factor positive 64.39 14.64 29 54258 629 29519611
Loss of consciousness 62.24 14.64 29 54258 74027 29446213
Seizure 62.11 14.64 48 54239 93075 29427165
Rhabdomyolysis 60.86 14.64 18 54269 60790 29459450
Disability 58.44 14.64 55 54232 4361 29515879
Hyperkalaemia 58.19 14.64 20 54267 61372 29458868
Intestinal sepsis 58.11 14.64 24 54263 418 29519822
Syncope 58.11 14.64 39 54248 81332 29438908
Muscle spasms 57.99 14.64 255 54032 64827 29455413
Rheumatoid nodule 57.07 14.64 40 54247 2082 29518158
Joint stiffness 56.49 14.64 78 54209 9395 29510845
Photosensitivity reaction 56.37 14.64 77 54210 9181 29511059
Somnolence 55.89 14.64 54 54233 93901 29426339
Hypokalaemia 55.75 14.64 12 54275 50191 29470049
General physical health deterioration 55.71 14.64 64 54223 102793 29417447
Alanine aminotransferase abnormal 55.62 14.64 45 54242 2912 29517328
Skin laceration 55.62 14.64 84 54203 10978 29509262
Drug effective for unapproved indication 55.18 14.64 34 54253 1421 29518819
Blood pressure diastolic decreased 54.71 14.64 66 54221 6956 29513284
Localised infection 54.55 14.64 94 54193 13722 29506518
Depression 54.15 14.64 46 54241 85101 29435139
Dysphagia 53.62 14.64 17 54270 54909 29465331
Lymphoedema 51.94 14.64 46 54241 3371 29516869
Gait inability 51.47 14.64 108 54179 18267 29501973
Immune effector cell-associated neurotoxicity syndrome 51.24 14.64 33 54254 1491 29518749
Prerenal failure 51.13 14.64 35 54252 1753 29518487
Disability assessment scale score increased 50.89 14.64 17 54270 157 29520083
Oxygen saturation decreased 50.29 14.64 189 54098 44748 29475492
Malaise 49.80 14.64 140 54147 159462 29360778
Fall 49.18 14.64 164 54123 177014 29343226
Coma 49.10 14.64 7 54280 39443 29480797
Hospitalisation 49.05 14.64 12 54275 45976 29474264
Liver function test increased 48.42 14.64 82 54205 11803 29508437
Immobile 48.34 14.64 37 54250 2208 29518032
Vision blurred 48.02 14.64 8 54279 40168 29480072
Osteolysis 48.02 14.64 32 54255 1533 29518707
Skin mass 47.71 14.64 44 54243 3399 29516841
Pulmonary fibrosis 47.68 14.64 95 54192 15487 29504753
Gastrointestinal haemorrhage 46.96 14.64 46 54241 79487 29440753
Seronegative arthritis 46.68 14.64 26 54261 898 29519342
International normalised ratio increased 46.51 14.64 12 54275 44360 29475880
Wrong technique in product usage process 45.85 14.64 3 54284 31425 29488815
Incorrect dose administered 45.71 14.64 4 54283 32980 29487260
Therapeutic product effect incomplete 45.39 14.64 167 54120 39138 29481102
Plasma cell myeloma 45.23 14.64 7 54280 37108 29483132
Blood pressure diastolic increased 45.16 14.64 44 54243 3642 29516598
Bronchopulmonary aspergillosis 44.88 14.64 81 54206 12263 29507977
Hip arthroplasty 44.44 14.64 44 54243 3714 29516526
Suicidal ideation 43.58 14.64 6 54281 34710 29485530
Oral surgery 43.50 14.64 21 54266 536 29519704
Infection 43.45 14.64 265 54022 76486 29443754
Anxiety 43.17 14.64 56 54231 85309 29434931
Musculoskeletal pain 43.13 14.64 134 54153 28819 29491421
Blood pressure systolic abnormal 43.02 14.64 34 54253 2127 29518113
Product dose omission issue 42.12 14.64 70 54217 96313 29423927
Hypoglycaemia 42.07 14.64 18 54269 48328 29471912
Hallucination 41.62 14.64 15 54272 44697 29475543
Depressed level of consciousness 40.67 14.64 9 54278 36933 29483307
Abscess 40.63 14.64 68 54219 9694 29510546
Drug tolerance decreased 40.04 14.64 27 54260 1319 29518921
Soft tissue swelling 39.90 14.64 17 54270 321 29519919
Medical device implantation 39.89 14.64 20 54267 555 29519685
Dysarthria 39.62 14.64 5 54282 30906 29489334
Mental status changes 39.49 14.64 8 54279 34919 29485321
Juvenile idiopathic arthritis 39.18 14.64 27 54260 1367 29518873
Atrial fibrillation 38.92 14.64 85 54202 105561 29414679
Blood fibrinogen decreased 38.80 14.64 23 54264 895 29519345
Blood glucose increased 38.56 14.64 31 54256 58953 29461287
Abdominal distension 38.53 14.64 18 54269 45893 29474347
Suicide attempt 38.18 14.64 8 54279 34102 29486138
Haematuria 37.51 14.64 17 54270 44122 29476118
Hand deformity 37.10 14.64 31 54256 2099 29518141
Osteoarthritis 37.01 14.64 94 54193 18009 29502231
Fine motor skill dysfunction 36.59 14.64 27 54260 1524 29518716
Blood creatinine increased 36.08 14.64 63 54224 85039 29435201
Agitation 36.06 14.64 25 54262 51279 29468961
Cytokine release syndrome 35.45 14.64 76 54211 13043 29507197
Aggression 34.68 14.64 11 54276 35530 29484710
Lactic acidosis 34.05 14.64 7 54280 30240 29490000
Poor venous access 33.71 14.64 35 54252 3126 29517114
Disseminated mucormycosis 33.07 14.64 15 54272 331 29519909
Myalgia 32.11 14.64 54 54233 73965 29446275
Blood pressure systolic increased 31.90 14.64 85 54202 16760 29503480
Abscess limb 29.92 14.64 33 54254 3158 29517082
Hypotension 29.61 14.64 222 54065 194132 29326108
Drug ineffective for unapproved indication 29.26 14.64 74 54213 14140 29506100
Thrombocytopenia 28.41 14.64 139 54148 134684 29385556
Amnesia 28.21 14.64 4 54283 22639 29497601
Herpes simplex viraemia 28.08 14.64 9 54278 72 29520168
Coronary artery disease 27.92 14.64 24 54263 44166 29476074
Unresponsive to stimuli 27.90 14.64 6 54281 25120 29495120
Hepatic steatosis 27.88 14.64 75 54212 14871 29505369
Renal impairment 27.88 14.64 68 54219 81265 29438975
Abdominal pain 27.69 14.64 141 54146 135216 29385024
Pancytopenia 27.37 14.64 71 54216 83097 29437143
Pulmonary toxicity 27.28 14.64 39 54248 4851 29515389
Joint injury 27.14 14.64 47 54240 6886 29513354
Infectious pleural effusion 27.11 14.64 25 54262 1931 29518309
Haematemesis 27.10 14.64 6 54281 24620 29495620
Interleukin level increased 27.05 14.64 9 54278 82 29520158
Septic shock 26.99 14.64 202 54085 62358 29457882
Pneumatosis intestinalis 26.69 14.64 31 54256 3138 29517102
Stent placement 26.49 14.64 36 54251 4270 29515970
Skin exfoliation 25.99 14.64 5 54282 22640 29497600
Gastrointestinal perforation 25.93 14.64 32 54255 3451 29516789
Cardio-respiratory arrest 25.77 14.64 33 54254 50568 29469672
Disorientation 25.66 14.64 11 54276 29504 29490736
Mucosal inflammation 25.57 14.64 13 54274 31582 29488658
Muscle strain 25.57 14.64 32 54255 3501 29516739
Lethargy 25.51 14.64 19 54268 37561 29482679
Irritability 25.20 14.64 5 54282 22147 29498093
Heart rate decreased 24.00 14.64 100 54187 24812 29495428
Chronic kidney disease 23.97 14.64 19 54268 36397 29483843
Rheumatoid factor 23.94 14.64 8 54279 74 29520166
Nephrolithiasis 23.87 14.64 101 54186 25233 29495007
Infective spondylitis 23.86 14.64 10 54277 181 29520059
Rheumatoid factor increased 23.78 14.64 14 54273 538 29519702
Inappropriate schedule of product administration 23.70 14.64 28 54259 44444 29475796
Diabetes mellitus 23.46 14.64 139 54148 39692 29480548
Haematocrit decreased 23.40 14.64 12 54275 29010 29491230
Ulcerative keratitis 23.33 14.64 20 54267 1403 29518837
Urinary retention 23.14 14.64 15 54272 31883 29488357
Abnormal behaviour 22.85 14.64 7 54280 23120 29497120
Large intestine perforation 22.68 14.64 45 54242 7311 29512929
Cytokine storm 22.34 14.64 14 54273 603 29519637
Neuropathy peripheral 22.34 14.64 62 54225 70965 29449275
Long QT syndrome 22.30 14.64 24 54263 2234 29518006
Tubulointerstitial nephritis 22.26 14.64 3 54284 17640 29502600
Intercepted product storage error 22.10 14.64 9 54278 151 29520089
Thrombosis 22.09 14.64 145 54142 42900 29477340
Lower respiratory tract congestion 22.08 14.64 17 54270 1023 29519217
Liver disorder 21.92 14.64 105 54182 27644 29492596
Pharyngitis 21.87 14.64 43 54244 6940 29513300
Respiratory arrest 21.87 14.64 10 54277 25823 29494417
Panniculitis 21.74 14.64 18 54269 1203 29519037
Hepatic cirrhosis 21.64 14.64 67 54220 14377 29505863
Hepatic enzyme increased 21.24 14.64 120 54167 33679 29486561
Chills 21.14 14.64 64 54223 71236 29449004
Infective chondritis 21.04 14.64 5 54282 10 29520230
Toxic epidermal necrolysis 20.85 14.64 4 54283 18149 29502091
Oral disorder 20.79 14.64 30 54257 3763 29516477
Hepatic enzyme abnormal 20.70 14.64 23 54264 2219 29518021
Excessive cerumen production 20.61 14.64 10 54277 258 29519982
Bursitis 20.56 14.64 34 54253 4798 29515442
Septic arthritis staphylococcal 20.15 14.64 12 54275 471 29519769
Cholestasis 19.99 14.64 9 54278 23453 29496787
Joint effusion 19.94 14.64 31 54256 4153 29516087
Intestinal perforation 19.76 14.64 45 54242 8041 29512199
Hypomagnesaemia 19.75 14.64 4 54283 17464 29502776
Treatment noncompliance 19.56 14.64 10 54277 24217 29496023
Liver function test 19.41 14.64 6 54281 42 29520198
Body temperature decreased 19.38 14.64 53 54234 10611 29509629
COVID-19 pneumonia 19.00 14.64 49 54238 9473 29510767
Blood cholesterol abnormal 18.99 14.64 18 54269 1440 29518800
Ankle operation 18.85 14.64 9 54278 224 29520016
Alveolar proteinosis 18.76 14.64 10 54277 316 29519924
Therapy partial responder 18.75 14.64 34 54253 5165 29515075
Red blood cell sedimentation rate 18.64 14.64 12 54275 542 29519698
Disturbance in attention 18.60 14.64 8 54279 21416 29498824
Drug withdrawal syndrome 18.58 14.64 5 54282 17979 29502261
White blood cell count increased 18.55 14.64 25 54262 37491 29482749
Paraesthesia 18.46 14.64 45 54242 53800 29466440
Diverticular perforation 18.44 14.64 25 54262 2959 29517281
Jaundice 18.39 14.64 16 54271 29280 29490960
Intentional product misuse 18.28 14.64 22 54265 34639 29485601
Osteonecrosis of jaw 18.21 14.64 4 54283 16506 29503734
Nausea 18.12 14.64 399 53888 288856 29231384
Suture rupture 18.07 14.64 10 54277 341 29519899
Oedema 18.04 14.64 29 54258 40454 29479786
Circulatory collapse 17.83 14.64 6 54281 18667 29501573
Weight increased 17.76 14.64 217 54070 76450 29443790
Visual impairment 17.73 14.64 17 54270 29691 29490549
Pulmonary hypertension 17.73 14.64 6 54281 18602 29501638
Metabolic acidosis 17.72 14.64 26 54261 37636 29482604
Neurological examination abnormal 17.62 14.64 9 54278 260 29519980
Respiratory tract infection bacterial 17.53 14.64 12 54275 601 29519639
Neutrophil count increased 17.47 14.64 3 54284 14739 29505501
Myocardial ischaemia 17.45 14.64 4 54283 16024 29504216
Dyspnoea exertional 17.36 14.64 25 54262 36465 29483775
Nasal crusting 17.30 14.64 10 54277 371 29519869
Inflammation 17.23 14.64 85 54202 22643 29497597
Squamous cell carcinoma of lung 17.23 14.64 18 54269 1619 29518621
Condition aggravated 17.22 14.64 370 53917 145925 29374315
Oesophageal rupture 17.16 14.64 10 54277 377 29519863
JC virus CSF test positive 17.16 14.64 7 54280 118 29520122
Therapy non-responder 17.01 14.64 106 54181 30805 29489435
Joint destruction 16.90 14.64 9 54278 284 29519956
Delirium 16.84 14.64 29 54258 39368 29480872
Haemorrhage 16.80 14.64 36 54251 45036 29475204
Blood pressure increased 16.71 14.64 208 54079 73595 29446645
Injection site pain 16.68 14.64 21 54266 32425 29487815
Human herpesvirus 6 encephalitis 16.65 14.64 8 54279 202 29520038
Chest pain 16.50 14.64 129 54158 111844 29408396
Gait disturbance 16.38 14.64 74 54213 73275 29446965
Therapeutic response decreased 16.37 14.64 89 54198 24622 29495618
Stevens-Johnson syndrome 16.28 14.64 5 54282 16492 29503748
Enterobacter pneumonia 16.18 14.64 5 54282 35 29520205
Gastrointestinal disorder 16.15 14.64 99 54188 28607 29491633
Angioedema 16.05 14.64 21 54266 31894 29488346
Solar urticaria 15.94 14.64 4 54283 11 29520229
Anorectal agenesis 15.91 14.64 3 54284 0 29520240
Fluid retention 15.87 14.64 12 54275 23548 29496692
Ventricular tachycardia 15.86 14.64 11 54276 22563 29497677
Oropharyngeal pain 15.85 14.64 100 54187 29185 29491055
Full blood count abnormal 15.84 14.64 4 54283 15009 29505231
Head injury 15.65 14.64 5 54282 16076 29504164
Oral herpes 15.54 14.64 29 54258 4503 29515737
Bradycardia foetal 15.42 14.64 9 54278 340 29519900
Cardiac arrest 15.38 14.64 93 54194 85498 29434742
Medication error 15.35 14.64 10 54277 21201 29499039
Disseminated intravascular coagulation 15.34 14.64 75 54212 19905 29500335
Post procedural infection 15.33 14.64 28 54259 4277 29515963
Blood potassium increased 15.28 14.64 4 54283 14647 29505593
Disease progression 15.26 14.64 88 54199 81828 29438412
Alopecia 15.22 14.64 8 54279 19076 29501164
Faeces discoloured 15.21 14.64 3 54284 13348 29506892
Pollakiuria 15.19 14.64 6 54281 16910 29503330
Herpes simplex reactivation 15.18 14.64 5 54282 44 29520196
Rectal haemorrhage 15.16 14.64 25 54262 34524 29485716
Product prescribing error 15.15 14.64 7 54280 17969 29502271
Aortoenteric fistula 14.99 14.64 6 54281 96 29520144
Clostridium difficile colitis 14.99 14.64 3 54284 13209 29507031
Listeria encephalitis 14.98 14.64 5 54282 46 29520194
Vertigo 14.90 14.64 11 54276 21850 29498390
Disseminated strongyloidiasis 14.88 14.64 6 54281 98 29520142
Hyperglycaemia 14.87 14.64 25 54262 34262 29485978
Scalloped tongue 14.80 14.64 4 54283 16 29520224
Dry mouth 14.80 14.64 11 54276 21773 29498467
Blood pressure fluctuation 14.80 14.64 74 54213 19820 29500420
Dysgeusia 14.70 14.64 12 54275 22662 29497578
Granuloma skin 14.66 14.64 11 54276 637 29519603

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 4939.04 13.70 10731 256214 829516 63402271
Joint swelling 3533.03 13.70 4396 262549 210986 64020801
Synovitis 3416.58 13.70 3012 263933 96078 64135709
Contraindicated product administered 3290.33 13.70 3060 263885 104769 64127018
Drug intolerance 3271.04 13.70 3954 262991 184038 64047749
Treatment failure 2537.62 13.70 2758 264187 114058 64117729
Arthropathy 2230.23 13.70 2623 264322 118344 64113443
Therapeutic product effect decreased 1942.18 13.70 2389 264556 112962 64118825
Arthralgia 1679.55 13.70 4805 262140 437455 63794332
Swelling 1355.88 13.70 2400 264545 157818 64073969
Pain 1321.67 13.70 5142 261803 548369 63683418
Hand deformity 1247.42 13.70 1416 265529 61355 64170432
Infusion related reaction 1246.49 13.70 2349 264596 162118 64069669
Hypersensitivity 1243.79 13.70 2602 264343 193850 64037937
Rheumatoid factor positive 1219.76 13.70 1071 265874 33867 64197920
C-reactive protein abnormal 1204.19 13.70 983 265962 28064 64203723
Pemphigus 1180.27 13.70 1354 265591 59347 64172440
Systemic lupus erythematosus 1129.30 13.70 1496 265449 76116 64155671
Hepatic enzyme increased 1112.40 13.70 1957 264988 127986 64103801
Toxicity to various agents 1057.27 13.70 131 266814 363382 63868405
Anti-cyclic citrullinated peptide antibody positive 1056.60 13.70 1160 265785 48402 64183385
Red blood cell sedimentation rate abnormal 1010.33 13.70 702 266243 15604 64216183
Off label use 991.17 13.70 5190 261755 627616 63604171
Glossodynia 987.57 13.70 1277 265668 63419 64168368
Acute kidney injury 961.44 13.70 331 266614 448909 63782878
Peripheral swelling 954.68 13.70 2436 264509 206717 64025070
Rheumatoid arthritis 918.04 13.70 2070 264875 162224 64069563
Abdominal discomfort 842.64 13.70 2134 264811 180188 64051599
Musculoskeletal stiffness 814.11 13.70 1662 265283 121544 64110243
Drug interaction 805.60 13.70 249 266696 361834 63869953
Intentional product use issue 799.85 13.70 1424 265521 93940 64137847
Death 784.72 13.70 518 266427 482187 63749600
Pericarditis 772.43 13.70 1114 265831 61402 64170385
Wound 754.95 13.70 1228 265717 75249 64156538
Anaemia 715.14 13.70 337 266608 378343 63853444
Drug hypersensitivity 704.95 13.70 2375 264570 235440 63996347
Bone erosion 680.61 13.70 483 266462 11112 64220675
Loss of personal independence in daily activities 662.29 13.70 1124 265821 71330 64160457
Nasopharyngitis 630.93 13.70 2014 264931 194059 64037728
Alopecia 622.23 13.70 1797 265148 163893 64067894
Red blood cell sedimentation rate increased 620.76 13.70 705 266240 30530 64201257
Lower respiratory tract infection 577.62 13.70 1236 265709 93378 64138409
Rash 559.16 13.70 3523 263422 455026 63776761
Infection 547.98 13.70 1847 265098 183033 64048754
Febrile neutropenia 544.00 13.70 68 266877 187589 64044198
Helicobacter infection 533.92 13.70 724 266221 37638 64194149
Drug abuse 524.74 13.70 4 266941 132370 64099417
Ill-defined disorder 505.03 13.70 758 266187 43294 64188493
Duodenal ulcer perforation 490.27 13.70 659 266286 33966 64197821
Dehydration 485.30 13.70 147 266798 216616 64015171
Impaired healing 485.06 13.70 886 266059 59587 64172200
Sinusitis 482.88 13.70 1514 265431 144414 64087373
Discomfort 471.25 13.70 1037 265908 79841 64151946
Hyponatraemia 465.32 13.70 40 266905 148299 64083488
Sleep disorder due to general medical condition, insomnia type 463.73 13.70 558 266387 25712 64206075
Muscle injury 447.90 13.70 550 266395 25887 64205900
Folliculitis 437.42 13.70 580 266365 29497 64202290
Overdose 416.42 13.70 78 266867 159488 64072299
C-reactive protein increased 411.09 13.70 1085 265860 93824 64137963
Irritable bowel syndrome 397.32 13.70 621 266324 36748 64195039
Therapeutic product effect incomplete 394.54 13.70 1129 265816 102353 64129434
Rheumatoid nodule 394.35 13.70 364 266581 12287 64219500
Malignant neoplasm progression 369.32 13.70 25 266920 112846 64118941
Mobility decreased 356.24 13.70 966 265979 84874 64146913
Intentional overdose 355.05 13.70 3 266942 89941 64141846
Arthritis 351.64 13.70 947 265998 82867 64148920
Weight increased 348.16 13.70 1774 265171 211574 64020213
Maternal exposure during pregnancy 341.42 13.70 1021 265924 94863 64136924
Seizure 334.29 13.70 136 266809 166756 64065031
Hyperkalaemia 326.23 13.70 24 266921 101105 64130682
Diverticulitis 322.58 13.70 576 266369 38042 64193745
Cardiac failure congestive 315.76 13.70 76 266869 130504 64101283
Dyspnoea 314.76 13.70 1721 265224 716953 63514834
Thrombocytopenia 310.87 13.70 281 266664 223520 64008267
Osteoporosis 303.15 13.70 589 266356 41491 64190296
Stomatitis 302.55 13.70 1070 265875 108535 64123252
Cardiac arrest 299.80 13.70 131 266814 153933 64077854
Drug eruption 298.01 13.70 536 266409 35600 64196187
Decreased appetite 296.08 13.70 441 266504 280848 63950939
Knee arthroplasty 295.83 13.70 455 266490 26544 64205243
Rhabdomyolysis 295.21 13.70 22 266923 91704 64140083
Somnolence 287.24 13.70 252 266693 203393 64028394
Joint stiffness 284.69 13.70 477 266468 29927 64201860
Skin ulcer 282.70 13.70 587 266358 43387 64188400
Product dose omission issue 278.30 13.70 238 266707 194509 64037278
Blister 274.92 13.70 848 266097 80119 64151668
Hypoglycaemia 266.73 13.70 30 266915 89862 64141925
Gastrointestinal haemorrhage 266.27 13.70 107 266838 132205 64099582
Coma 265.70 13.70 27 266918 87588 64144199
Inflammation 265.03 13.70 729 266216 64571 64167216
Constipation 264.95 13.70 336 266609 229001 64002786
Blood parathyroid hormone decreased 261.31 13.70 228 266717 7138 64224649
Cardio-respiratory arrest 258.99 13.70 47 266898 98346 64133441
Granuloma skin 258.85 13.70 209 266736 5865 64225922
Panniculitis 258.54 13.70 246 266699 8633 64223154
Asthenia 257.42 13.70 909 266036 427135 63804652
Dizziness 256.36 13.70 917 266028 429246 63802541
Coeliac disease 256.08 13.70 226 266719 7186 64224601
Condition aggravated 254.10 13.70 2504 264441 369922 63861865
Atrial fibrillation 251.95 13.70 203 266742 170886 64060901
Bradycardia 250.61 13.70 88 266857 118131 64113656
Suicide attempt 240.49 13.70 13 266932 70994 64160793
Hypotension 239.89 13.70 793 266152 380181 63851606
Diarrhoea 238.55 13.70 1884 265061 720820 63510967
Hypokalaemia 235.01 13.70 105 266840 121798 64109989
Disability assessment scale score increased 233.53 13.70 140 266805 2390 64229397
Depressed level of consciousness 232.25 13.70 31 266914 81405 64150382
No adverse event 228.33 13.70 418 266527 28143 64203644
Renal failure 228.24 13.70 249 266696 181439 64050348
Anxiety 226.74 13.70 304 266641 202345 64029442
Syncope 225.96 13.70 192 266753 157443 64074344
Musculoskeletal pain 225.45 13.70 795 266150 80499 64151288
International normalised ratio increased 221.38 13.70 32 266913 79135 64152652
Pancytopenia 219.93 13.70 163 266782 143146 64088641
Therapeutic response decreased 216.12 13.70 587 266358 51601 64180186
Tremor 213.13 13.70 180 266765 148050 64083737
Gastrointestinal disorder 211.80 13.70 833 266112 88876 64142911
Hip arthroplasty 210.68 13.70 343 266602 21008 64210779
Blood pressure systolic increased 210.58 13.70 562 266383 48891 64182896
Blood pressure diastolic decreased 207.61 13.70 349 266596 21952 64209835
Vomiting 207.50 13.70 1383 265562 549734 63682053
Blood pressure diastolic abnormal 206.80 13.70 251 266694 11666 64220121
Cardiac failure 206.46 13.70 148 266797 132225 64099562
Osteoarthritis 201.79 13.70 649 266296 62687 64169100
Tachycardia 199.14 13.70 195 266750 149384 64082403
Agitation 197.45 13.70 60 266885 88307 64143480
Product use issue 194.81 13.70 1183 265762 150532 64081255
Electrocardiogram QT prolonged 194.47 13.70 45 266900 79403 64152384
Lactic acidosis 191.29 13.70 17 266928 61393 64170394
Injection site pain 190.83 13.70 112 266833 111296 64120491
Fibromyalgia 189.99 13.70 442 266503 35289 64196498
Blood cholesterol increased 189.47 13.70 545 266400 49521 64182266
Metabolic acidosis 186.50 13.70 34 266911 70924 64160863
Blood pressure systolic abnormal 185.02 13.70 217 266728 9725 64222062
Cerebrovascular accident 181.26 13.70 181 266764 137402 64094385
Rheumatic fever 179.89 13.70 207 266738 9087 64222700
Pyrexia 178.60 13.70 1468 265477 557176 63674611
Hallucination 176.63 13.70 42 266903 72746 64159041
Respiratory failure 176.02 13.70 246 266699 160937 64070850
Neuropathy peripheral 174.78 13.70 138 266807 117387 64114400
Haemoglobin decreased 171.98 13.70 342 266603 194721 64037066
Disease progression 171.53 13.70 200 266745 141480 64090307
Wrong technique in product usage process 168.90 13.70 32 266913 64942 64166845
Dysarthria 168.47 13.70 23 266922 59383 64172404
Depression 165.36 13.70 317 266628 182974 64048813
Unresponsive to stimuli 165.27 13.70 11 266934 50382 64181405
Drug tolerance decreased 165.20 13.70 173 266772 6825 64224962
Mental status changes 159.25 13.70 30 266915 61132 64170655
Ear pain 158.56 13.70 333 266612 24803 64206984
Neutropenia 158.16 13.70 488 266457 239136 63992651
Rheumatoid factor negative 157.23 13.70 81 266864 1012 64230775
Dysphagia 156.85 13.70 127 266818 106685 64125102
Hyperglycaemia 156.42 13.70 31 266914 60937 64170850
Respiratory arrest 156.37 13.70 18 266927 52967 64178820
Sciatica 156.22 13.70 292 266653 19972 64211815
Joint destruction 154.70 13.70 125 266820 3511 64228276
Foot deformity 153.25 13.70 258 266687 16246 64215541
Abdominal pain 153.19 13.70 718 266227 311657 63920130
Temperature regulation disorder 152.71 13.70 132 266813 4079 64227708
Lethargy 152.18 13.70 55 266890 72539 64159248
Vision blurred 151.57 13.70 93 266852 90223 64141564
Apparent death 151.34 13.70 109 266836 2567 64229220
Orthostatic hypotension 150.96 13.70 11 266934 46727 64185060
Urticaria 149.90 13.70 1084 265861 146233 64085554
Coronary artery disease 148.36 13.70 34 266911 60399 64171388
Immunodeficiency 148.31 13.70 251 266694 15873 64215914
Balance disorder 147.11 13.70 82 266863 83844 64147943
Oral mucosal exfoliation 146.70 13.70 84 266861 1311 64230476
Inappropriate schedule of product administration 145.43 13.70 102 266843 92184 64139603
Haematuria 144.56 13.70 36 266909 60435 64171352
Drug reaction with eosinophilia and systemic symptoms 142.43 13.70 26 266919 54191 64177596
Limb deformity 141.84 13.70 115 266830 3246 64228541
Aggression 140.79 13.70 14 266931 46218 64185569
Plasma cell myeloma 140.19 13.70 14 266931 46061 64185726
Skin necrosis 139.75 13.70 229 266716 14100 64217687
Cognitive disorder 137.22 13.70 30 266915 55057 64176730
Fall 136.84 13.70 1087 265858 415739 63816048
Herpes zoster 136.34 13.70 669 266276 78518 64153269
Impaired work ability 136.14 13.70 234 266711 14985 64216802
Psoriatic arthropathy 135.57 13.70 441 266504 42840 64188947
Blood pressure fluctuation 135.03 13.70 497 266448 51374 64180413
Joint laxity 134.87 13.70 96 266849 2218 64229569
Swollen joint count increased 131.87 13.70 161 266784 7528 64224259
Blood pressure diastolic increased 131.79 13.70 191 266754 10561 64221226
Physical disability 131.34 13.70 94 266851 2191 64229596
Chest pain 130.56 13.70 518 266427 235462 63996325
Intentional product misuse 130.56 13.70 68 266877 72227 64159560
Pain in extremity 130.17 13.70 1866 265079 301219 63930568
Bursitis 130.16 13.70 280 266665 21205 64210582
Joint injury 129.89 13.70 291 266654 22656 64209131
Hypomagnesaemia 129.23 13.70 6 266939 37370 64194417
Tenosynovitis 129.02 13.70 199 266746 11634 64220153
Nodule 128.96 13.70 251 266694 17696 64214091
Pulmonary fibrosis 128.64 13.70 341 266604 29537 64202250
Neoplasm progression 128.50 13.70 11 266934 40953 64190834
Disorientation 128.20 13.70 36 266909 55792 64175995
Disturbance in attention 126.23 13.70 12 266933 41062 64190725
Investigation abnormal 125.68 13.70 75 266870 1269 64230518
Oedema peripheral 125.22 13.70 448 266497 209869 64021918
Nausea 124.93 13.70 2398 264547 783402 63448385
Serotonin syndrome 124.74 13.70 10 266935 39272 64192515
Blood alkaline phosphatase increased 124.30 13.70 39 266906 56240 64175547
Ascites 123.29 13.70 51 266894 61950 64169837
Sedation 122.56 13.70 14 266931 41448 64190339
Heart rate decreased 122.46 13.70 502 266443 54565 64177222
Pneumonia aspiration 122.39 13.70 46 266899 59225 64172562
Toxic epidermal necrolysis 122.21 13.70 8 266937 37158 64194629
Platelet count decreased 122.00 13.70 326 266619 167385 64064402
Food allergy 121.26 13.70 156 266789 7695 64224092
Blood creatinine increased 120.55 13.70 237 266708 135545 64096242
Blood glucose increased 120.24 13.70 137 266808 97936 64133851
Musculoskeletal deformity 119.41 13.70 57 266888 597 64231190
Haematemesis 118.28 13.70 25 266920 46974 64184813
Joint range of motion decreased 118.23 13.70 253 266692 19090 64212697
Urinary retention 118.17 13.70 29 266916 49172 64182615
Pleural effusion 117.53 13.70 215 266730 126344 64105443
Mucosal inflammation 117.33 13.70 56 266889 62528 64169259
Human antichimeric antibody positive 116.99 13.70 73 266872 1343 64230444
Pulmonary hypertension 114.81 13.70 20 266925 43119 64188668
Dyskinesia 114.69 13.70 14 266931 39374 64192413
Adverse event 114.47 13.70 392 266553 39097 64192690
Body height below normal 114.29 13.70 79 266866 1739 64230048
Acute myocardial infarction 113.93 13.70 74 266871 69644 64162143
Restlessness 113.77 13.70 15 266930 39770 64192017
Loss of consciousness 113.59 13.70 281 266664 148084 64083703
Hypophagia 113.02 13.70 15 266930 39572 64192215
Bronchitis chronic 112.69 13.70 108 266837 3824 64227963
Jaundice 111.92 13.70 31 266914 48481 64183306
Generalised tonic-clonic seizure 111.67 13.70 16 266929 39841 64191946
Skin exfoliation 110.68 13.70 25 266920 44860 64186927
Pulmonary oedema 110.04 13.70 98 266847 78576 64153211
Ulcer 109.96 13.70 273 266672 22717 64209070
Contusion 109.29 13.70 827 266118 113138 64118649
Oral herpes 109.07 13.70 266 266679 21886 64209901
Abnormal behaviour 108.34 13.70 8 266937 33614 64198173
Delirium 108.32 13.70 77 266868 69117 64162670
Drug withdrawal syndrome 108.26 13.70 5 266940 31286 64200501
Accidental overdose 108.08 13.70 8 266937 33549 64198238
Chest discomfort 107.13 13.70 198 266747 115908 64115879
Incorrect dose administered 107.02 13.70 59 266886 60706 64171081
Basal cell carcinoma 106.48 13.70 325 266620 30513 64201274
Paraesthesia 105.17 13.70 252 266693 134270 64097517
Hypofibrinogenaemia 104.17 13.70 74 266871 1704 64230083
Chronic obstructive pulmonary disease 103.64 13.70 85 266860 70963 64160824
Suicidal ideation 102.92 13.70 75 266870 66467 64165320
Bone marrow failure 102.78 13.70 35 266910 47917 64183870
Intentional self-injury 102.62 13.70 4 266941 29040 64202747
Emotional distress 102.06 13.70 14 266931 36024 64195763
Deformity 101.80 13.70 128 266817 6169 64225618
Joint arthroplasty 101.66 13.70 77 266868 1963 64229824
Immobile 101.62 13.70 125 266820 5890 64225897
Myalgia 101.09 13.70 328 266617 158289 64073498
Ventricular tachycardia 100.21 13.70 12 266933 34253 64197534
Gastric disorder 100.15 13.70 307 266638 28890 64202897
Treatment noncompliance 99.91 13.70 28 266917 43454 64188333
Disability 99.62 13.70 180 266765 11992 64219795
Diabetic ketoacidosis 99.40 13.70 6 266939 29839 64201948
Product prescribing error 99.18 13.70 14 266931 35255 64196532
Rheumatoid lung 98.70 13.70 82 266863 2397 64229390
Blood creatine phosphokinase increased 98.66 13.70 60 266885 58498 64173289
Polyarthritis 98.46 13.70 158 266787 9557 64222230
Dyspnoea exertional 98.21 13.70 96 266849 73634 64158153
Circulatory collapse 98.19 13.70 12 266933 33720 64198067
Tubulointerstitial nephritis 97.78 13.70 8 266937 30901 64200886
Confusional state 97.61 13.70 656 266289 260488 63971299
Surgical failure 97.35 13.70 53 266892 746 64231041
Blood bilirubin increased 95.53 13.70 60 266885 57493 64174294
Stevens-Johnson syndrome 95.37 13.70 14 266931 34235 64197552
Melaena 94.29 13.70 52 266893 53496 64178291
Arthritis bacterial 94.25 13.70 138 266807 7701 64224086
Hepatitis 93.92 13.70 406 266539 45176 64186611
Gastrooesophageal reflux disease 92.62 13.70 125 266820 83018 64148769
Bone cyst 92.35 13.70 75 266870 2122 64229665
Feeling abnormal 91.72 13.70 267 266678 133335 64098452
Fine motor skill dysfunction 91.51 13.70 105 266840 4594 64227193
Drug level increased 90.68 13.70 16 266929 34180 64197607
Blood pressure increased 90.03 13.70 1101 265844 171451 64060336
Chronic kidney disease 89.94 13.70 65 266880 57854 64173933
Blood urea increased 89.94 13.70 35 266910 44118 64187669
Hypoxia 89.88 13.70 141 266804 88008 64143779
Red blood cell sedimentation rate 89.79 13.70 93 266852 3621 64228166
Blood sodium decreased 89.58 13.70 9 266936 29473 64202314
Irritability 89.54 13.70 21 266924 36725 64195062
Liver function test increased 89.38 13.70 307 266638 30663 64201124
Hypervolaemia 89.19 13.70 24 266921 38261 64193526
Cholestasis 89.06 13.70 37 266908 44835 64186952
Osteonecrosis of jaw 89.02 13.70 27 266918 39798 64191989
Muscle spasticity 88.37 13.70 206 266739 16463 64215324
Hospitalisation 87.97 13.70 109 266836 75098 64156689
Sinus tachycardia 87.70 13.70 14 266931 32174 64199613
Haemophagocytic lymphohistiocytosis 87.29 13.70 212 266733 17397 64214390
Femur fracture 87.10 13.70 325 266620 33810 64197977
Pneumonia 86.74 13.70 1714 265231 557862 63673925
Ejection fraction decreased 86.61 13.70 9 266936 28698 64203089
Angioedema 86.46 13.70 77 266868 61744 64170043
Musculoskeletal disorder 86.02 13.70 213 266732 17693 64214094
Psychotic disorder 85.78 13.70 19 266926 34559 64197228
Arthrodesis 85.70 13.70 70 266875 1997 64229790
Toothache 85.27 13.70 209 266736 17250 64214537
Rectal haemorrhage 85.25 13.70 78 266867 61739 64170048
Cerebral haemorrhage 85.16 13.70 53 266892 51037 64180750
Bone density decreased 85.08 13.70 150 266795 9802 64221985
Depressed mood 84.38 13.70 32 266913 40980 64190807
Renal impairment 84.09 13.70 282 266663 134735 64097052
Blood pressure decreased 84.03 13.70 142 266803 86057 64145730
Blood potassium decreased 84.00 13.70 31 266914 40368 64191419
Palpitations 83.85 13.70 193 266752 104295 64127492
Hepatic failure 83.65 13.70 64 266881 55330 64176457
Presyncope 83.65 13.70 21 266924 35068 64196719
Accidental exposure to product 82.91 13.70 7 266938 26357 64205430
Grip strength decreased 81.85 13.70 162 266783 11562 64220225
Loose body in joint 81.48 13.70 55 266890 1163 64230624
Myoclonus 80.86 13.70 6 266939 25112 64206675
Colitis microscopic 79.64 13.70 124 266821 7308 64224479
Chills 79.27 13.70 296 266649 136968 64094819
Product quality issue 78.89 13.70 14 266931 29785 64202002
Upper gastrointestinal haemorrhage 78.50 13.70 24 266921 35196 64196591
Myocardial infarction 78.33 13.70 386 266559 165435 64066352
Memory impairment 78.25 13.70 147 266798 85535 64146252
Arrhythmia 77.64 13.70 63 266882 52881 64178906
Cardiac disorder 77.48 13.70 70 266875 55746 64176041
Dysuria 76.76 13.70 39 266906 42018 64189769
Sepsis 76.21 13.70 599 266346 229742 64002045
Haemorrhage 76.17 13.70 132 266813 79219 64152568
Speech disorder 75.69 13.70 54 266891 48387 64183400
Body temperature decreased 75.68 13.70 258 266687 25670 64206117
Dysgeusia 75.43 13.70 51 266894 46996 64184791
Localised infection 75.16 13.70 285 266660 29876 64201911
Pharyngitis 74.68 13.70 210 266735 18829 64212958
Osteoporotic fracture 74.50 13.70 83 266862 3515 64228272
Adverse drug reaction 73.92 13.70 378 266567 45086 64186701
Myocardial ischaemia 73.60 13.70 6 266939 23245 64208542
Respiratory distress 73.40 13.70 65 266880 52266 64179521
Haemorrhage intracranial 73.33 13.70 7 266938 23877 64207910
Terminal state 71.31 13.70 90 266855 4354 64227433
Gamma-glutamyltransferase increased 70.79 13.70 58 266887 48452 64183335
Transient ischaemic attack 70.69 13.70 48 266897 44134 64187653
Presbyacusis 70.55 13.70 69 266876 2506 64229281
Haematochezia 69.74 13.70 104 266841 66269 64165518
Withdrawal syndrome 69.26 13.70 8 266937 23484 64208303
Fatigue 69.20 13.70 3772 263173 744958 63486829
Visual acuity reduced 69.20 13.70 14 266931 27127 64204660
Abdominal distension 68.71 13.70 188 266757 95806 64135981
Limb mass 68.32 13.70 73 266872 2948 64228839
Altered state of consciousness 67.91 13.70 36 266909 37866 64193921
Oxygen saturation decreased 67.69 13.70 710 266235 106466 64125321
Blood calcium decreased 67.66 13.70 12 266933 25542 64206245
Flushing 67.45 13.70 140 266805 78508 64153279
Glaucoma 66.77 13.70 183 266762 16165 64215622
Pericardial effusion 66.43 13.70 40 266905 39214 64192573
Haematocrit decreased 66.27 13.70 77 266868 54578 64177209
Cutaneous vasculitis 65.22 13.70 105 266840 6368 64225419
Rash macular 65.22 13.70 10 266935 23675 64208112
Cardiomegaly 65.21 13.70 10 266935 23674 64208113
Haemoptysis 65.16 13.70 64 266881 48984 64182803
Full blood count abnormal 65.03 13.70 21 266924 29736 64202051
Pulmonary embolism 64.98 13.70 348 266597 146008 64085779
Inappropriate antidiuretic hormone secretion 64.70 13.70 8 266937 22281 64209506
Onychomycosis 64.70 13.70 93 266852 5103 64226684
Joint effusion 64.44 13.70 160 266785 13313 64218474
Pollakiuria 64.21 13.70 25 266920 31505 64200282
Cardiogenic shock 63.93 13.70 27 266918 32400 64199387
Ataxia 63.93 13.70 8 266937 22076 64209711
Aphasia 63.39 13.70 46 266899 40860 64190927
Intestinal sepsis 63.11 13.70 37 266908 605 64231182
Infusion site reaction 63.03 13.70 59 266886 2027 64229760
X-ray abnormal 62.77 13.70 51 266894 1444 64230343
Body temperature increased 62.53 13.70 309 266636 36357 64195430
Electrolyte imbalance 62.35 13.70 14 266931 25229 64206558
Respiratory depression 62.09 13.70 11 266934 23432 64208355
Tooth disorder 61.98 13.70 219 266726 22183 64209604
Clostridium difficile colitis 61.67 13.70 18 266927 27205 64204582
Multiple organ dysfunction syndrome 61.65 13.70 214 266731 101199 64130588
Retinal toxicity 61.46 13.70 48 266897 1282 64230505
Subdural haematoma 60.95 13.70 20 266925 28034 64203753
Mental disorder 60.81 13.70 17 266928 26428 64205359
Type 2 diabetes mellitus 60.38 13.70 290 266655 33730 64198057
Hemiparesis 60.16 13.70 24 266921 29803 64201984
Nightmare 59.82 13.70 8 266937 20985 64210802
Muscle rigidity 59.78 13.70 3 266942 17470 64214317
Dystonia 59.35 13.70 5 266940 18860 64212927
Device issue 59.18 13.70 11 266934 22637 64209150
Pulmonary thrombosis 59.09 13.70 133 266812 10385 64221402
Obstructive airways disorder 59.02 13.70 12 266933 23173 64208614
Delusion 58.86 13.70 4 266941 18010 64213777
Acute respiratory failure 58.78 13.70 72 266873 49862 64181925
Pneumonia viral 58.16 13.70 111 266834 7711 64224076
Blood iron abnormal 58.11 13.70 44 266901 1121 64230666
Sinus bradycardia 57.97 13.70 12 266933 22881 64208906
Product administration error 57.82 13.70 21 266924 27622 64204165
Myelodysplastic syndrome 57.61 13.70 21 266924 27558 64204229
Hypersomnia 57.42 13.70 7 266938 19710 64212077
Encephalopathy 57.22 13.70 97 266848 58722 64173065
Transplant rejection 56.47 13.70 4 266941 17397 64214390
Small intestinal obstruction 56.40 13.70 14 266931 23559 64208228
Joint lock 56.39 13.70 64 266881 2767 64229020
Torsade de pointes 56.32 13.70 4 266941 17359 64214428
Epilepsy 55.58 13.70 35 266910 33496 64198291
Hepatic encephalopathy 55.54 13.70 10 266935 21056 64210731
Injection site erythema 55.02 13.70 133 266812 70667 64161120
Aspiration 54.45 13.70 4 266941 16881 64214906
Bone pain 53.50 13.70 71 266874 47501 64184286
Urinary tract infection 53.16 13.70 658 266287 230938 64000849
Therapy non-responder 52.73 13.70 459 266486 65440 64166347
Sleep disorder 52.62 13.70 425 266520 59284 64172503
Haemodialysis 52.44 13.70 5 266940 17072 64214715
Acute myeloid leukaemia 52.35 13.70 24 266921 27439 64204348
Mental impairment 52.34 13.70 4 266941 16339 64215448
Tricuspid valve incompetence 52.16 13.70 5 266940 16998 64214789
Mania 52.11 13.70 4 266941 16282 64215505
Ventricular fibrillation 51.85 13.70 17 266928 23843 64207944
Pleural thickening 51.84 13.70 60 266885 2650 64229137
Pulmonary arterial hypertension 51.84 13.70 20 266925 25347 64206440
Atelectasis 51.71 13.70 24 266921 27242 64204545
Gastritis 51.71 13.70 60 266885 42558 64189229
Spinal column injury 51.44 13.70 50 266895 1802 64229985
Blood albumin decreased 51.43 13.70 12 266933 21061 64210726
Faeces discoloured 51.41 13.70 21 266924 25708 64206079
Unevaluable event 51.23 13.70 81 266864 50408 64181379
Pleural fibrosis 51.18 13.70 73 266872 3977 64227810
Hypothermia 51.13 13.70 10 266935 19846 64211941
Mitral valve incompetence 50.77 13.70 21 266924 25517 64206270
Skin papilloma 50.53 13.70 83 266862 5120 64226667
Muscular weakness 50.50 13.70 314 266631 127024 64104763
Anuria 50.01 13.70 9 266936 18955 64212832
White blood cell count increased 49.74 13.70 126 266819 65888 64165899
Metastases to bone 49.15 13.70 12 266933 20423 64211364
Diverticular perforation 49.07 13.70 82 266863 5131 64226656
Antibody test positive 48.94 13.70 55 266890 2352 64229435
Angina unstable 48.93 13.70 4 266941 15463 64216324
Soft tissue disorder 48.88 13.70 64 266881 3212 64228575
Cardiomyopathy 48.58 13.70 22 266923 25334 64206453
Viral upper respiratory tract infection 48.54 13.70 106 266839 8109 64223678
Demyelination 48.39 13.70 95 266850 6739 64225048
Bone disorder 48.24 13.70 166 266779 16593 64215194
Fear 48.22 13.70 12 266933 20159 64211628
Urinary incontinence 48.22 13.70 47 266898 36104 64195683
White blood cell count decreased 47.84 13.70 420 266525 157417 64074370
Blood lactate dehydrogenase increased 47.70 13.70 40 266905 33038 64198749
Wheezing 47.66 13.70 172 266773 80407 64151380
Renal tubular necrosis 47.62 13.70 16 266929 22094 64209693
Anti-cyclic citrullinated peptide antibody 47.46 13.70 42 266903 1340 64230447
Hypocalcaemia 47.28 13.70 62 266883 41691 64190096
Respiratory disorder 47.17 13.70 283 266662 35828 64195959
Hallucination, auditory 46.99 13.70 7 266938 16932 64214855
Dialysis 46.91 13.70 7 266938 16913 64214874
Intestinal obstruction 46.32 13.70 49 266896 36237 64195550
Pancreatitis 46.29 13.70 112 266833 59495 64172292
Drug specific antibody 46.28 13.70 50 266895 2045 64229742
Agranulocytosis 46.19 13.70 54 266891 38175 64193612
Hypophosphataemia 46.04 13.70 4 266941 14716 64217071
Poor venous access 45.83 13.70 134 266811 12283 64219504
Pallor 45.56 13.70 56 266889 38725 64193062
Lymphocyte count decreased 45.51 13.70 61 266884 40638 64191149
Graft versus host disease 45.33 13.70 3 266942 13810 64217977
Bedridden 45.17 13.70 117 266828 9992 64221795
Colitis 44.97 13.70 111 266834 58563 64173224
Nephropathy toxic 44.72 13.70 9 266936 17505 64214282
Blood glucose decreased 44.40 13.70 20 266925 23103 64208684
Oesophagitis 44.29 13.70 17 266928 21613 64210174
Diplopia 44.28 13.70 28 266917 26737 64205050
Lower limb fracture 44.21 13.70 140 266805 13405 64218382
Malignant melanoma 44.16 13.70 136 266809 12828 64218959
Injection site hypersensitivity 44.16 13.70 44 266901 1635 64230152
Tooth infection 44.12 13.70 147 266798 14454 64217333
Shock 44.11 13.70 56 266889 38184 64193603
Arteriosclerosis coronary artery 44.05 13.70 6 266939 15523 64216264
Hypercholesterolaemia 44.01 13.70 152 266793 15221 64216566
Hyperlipidaemia 43.92 13.70 20 266925 22956 64208831
Ileus 43.89 13.70 20 266925 22946 64208841
Hypovolaemia 43.89 13.70 6 266939 15480 64216307
Mass 43.70 13.70 151 266794 15125 64216662
Tachypnoea 43.68 13.70 28 266917 26543 64205244
Blood magnesium increased 43.45 13.70 60 266885 3171 64228616
Juvenile idiopathic arthritis 43.36 13.70 66 266879 3813 64227974
Acute coronary syndrome 43.32 13.70 13 266932 19297 64212490
Drug specific antibody present 43.18 13.70 77 266868 5077 64226710
Seronegative arthritis 43.14 13.70 55 266890 2688 64229099
Dry skin 43.08 13.70 92 266853 51069 64180718
Deep vein thrombosis 42.94 13.70 257 266688 104925 64126862
Metastases to central nervous system 42.92 13.70 4 266941 13908 64217879
Multiple fractures 42.81 13.70 84 266861 5956 64225831
Anal incontinence 42.80 13.70 6 266939 15190 64216597
Status epilepticus 42.77 13.70 18 266927 21645 64210142
Systemic lupus erythematosus rash 42.47 13.70 40 266905 1385 64230402
Glomerular filtration rate decreased 42.44 13.70 14 266931 19558 64212229
Cytology abnormal 42.35 13.70 23 266922 322 64231465
Atrioventricular block complete 42.28 13.70 5 266940 14413 64217374
Myelosuppression 42.15 13.70 23 266922 23807 64207980
Dermatitis allergic 42.05 13.70 148 266797 14961 64216826
Coagulopathy 41.99 13.70 42 266903 31878 64199909
Frequent bowel movements 41.66 13.70 12 266933 18293 64213494
Drug use disorder 41.47 13.70 83 266862 5971 64225816
Hypokinesia 41.40 13.70 9 266936 16587 64215200
Transaminases abnormal 40.95 13.70 30 266915 726 64231061
Acute generalised exanthematous pustulosis 40.92 13.70 5 266940 14053 64217734
Ventricular extrasystoles 40.81 13.70 11 266934 17518 64214269
Dry mouth 40.53 13.70 122 266823 60296 64171491
Sinus disorder 40.53 13.70 10 266935 16898 64214889
Muscle twitching 40.48 13.70 14 266931 18984 64212803
Neutrophil count decreased 40.41 13.70 173 266772 77023 64154764
Iron deficiency anaemia 40.39 13.70 20 266925 21869 64209918
Prothrombin time prolonged 40.38 13.70 8 266937 15733 64216054
Finger deformity 40.30 13.70 75 266870 5111 64226676
Head injury 40.10 13.70 46 266899 32796 64198991
Red blood cell count decreased 39.92 13.70 88 266857 48298 64183489
Exostosis 39.90 13.70 121 266824 11317 64220470
Toxic skin eruption 39.75 13.70 15 266930 19269 64212518
Brain oedema 39.50 13.70 21 266924 22054 64209733
Myopathy 39.49 13.70 12 266933 17668 64214119
Night sweats 39.39 13.70 270 266675 35776 64196011
Hyperhidrosis 39.37 13.70 329 266616 124591 64107196
Device malfunction 39.32 13.70 12 266933 17621 64214166
Immune effector cell-associated neurotoxicity syndrome 39.19 13.70 51 266894 2544 64229243
Oropharyngeal pain 39.17 13.70 550 266395 88317 64143470
Right ventricular failure 39.05 13.70 20 266925 21451 64210336
Hepatitis B virus test positive 38.97 13.70 24 266921 431 64231356
Infiltration anaesthesia 38.94 13.70 17 266928 142 64231645
Paranoia 38.56 13.70 10 266935 16342 64215445
Flatulence 38.33 13.70 55 266890 35611 64196176
Interstitial lung disease 38.04 13.70 592 266353 97140 64134647
Vasculitic rash 37.95 13.70 44 266901 1947 64229840
Onychomadesis 37.95 13.70 53 266892 2831 64228956
Hypercalcaemia 37.76 13.70 241 266704 31175 64200612
Mean platelet volume decreased 37.69 13.70 41 266904 1690 64230097
Lip swelling 37.56 13.70 46 266899 31861 64199926
Deafness neurosensory 37.38 13.70 82 266863 6292 64225495
Renal injury 37.23 13.70 9 266936 15420 64216367
Acute hepatic failure 37.14 13.70 32 266913 26080 64205707
Troponin increased 37.12 13.70 9 266936 15390 64216397
Vascular access complication 36.97 13.70 33 266912 1065 64230722
Leukocytosis 36.93 13.70 62 266883 37678 64194109
Face oedema 36.88 13.70 29 266916 24732 64207055
Second primary malignancy 36.88 13.70 4 266941 12333 64219454
Lower respiratory tract congestion 36.87 13.70 53 266892 2908 64228879
Supraventricular tachycardia 36.86 13.70 16 266929 18891 64212896
Full blood count decreased 36.84 13.70 24 266921 22558 64209229
Device dislocation 36.65 13.70 21 266924 21157 64210630
Multiple allergies 36.63 13.70 77 266868 5737 64226050
Pulmonary mass 36.50 13.70 196 266749 23820 64207967
Eating disorder 36.47 13.70 12 266933 16793 64214994
Concomitant disease aggravated 36.47 13.70 3 266942 11539 64220248
Alanine aminotransferase abnormal 36.37 13.70 85 266860 6803 64224984
Drug level decreased 36.32 13.70 3 266942 11500 64220287
Vertigo 36.21 13.70 124 266821 58887 64172900
Hepatitis cholestatic 36.18 13.70 4 266941 12151 64219636
Feeling hot 36.09 13.70 85 266860 45578 64186209
Haematoma 35.83 13.70 87 266858 46163 64185624
Peripheral sensory neuropathy 35.83 13.70 3 266942 11375 64220412
Blood magnesium decreased 35.81 13.70 7 266938 13898 64217889
Clostridium difficile infection 35.76 13.70 59 266886 36104 64195683
Haemolytic anaemia 35.66 13.70 11 266934 16042 64215745
Wheelchair user 35.60 13.70 67 266878 4605 64227182
Cyanosis 35.53 13.70 24 266921 22131 64209656
Caesarean section 35.43 13.70 3 266942 11271 64220516
Mood altered 35.41 13.70 11 266934 15968 64215819
Coronary artery stenosis 35.33 13.70 3 266942 11245 64220542
Atrial flutter 35.32 13.70 18 266927 19362 64212425
Synovial cyst 35.26 13.70 90 266855 7617 64224170
Left ventricular dysfunction 35.26 13.70 13 266932 16941 64214846
Infected bite 35.16 13.70 35 266910 1299 64230488
Injection site mass 34.66 13.70 14 266931 17256 64214531
Progressive multifocal leukoencephalopathy 34.65 13.70 16 266929 18216 64213571
Foot fracture 34.58 13.70 158 266787 17999 64213788
Extremity contracture 34.53 13.70 38 266907 1587 64230200
Mesenteritis 34.42 13.70 17 266928 193 64231594
Haematotoxicity 34.26 13.70 6 266939 12890 64218897
Drug tolerance 34.24 13.70 77 266868 6008 64225779
Injection site reaction 34.24 13.70 319 266626 46345 64185442
Activated partial thromboplastin time prolonged 34.03 13.70 6 266939 12825 64218962
Secretion discharge 33.99 13.70 118 266827 11846 64219941
Ageusia 33.44 13.70 8 266937 13805 64217982
Nervousness 33.35 13.70 44 266901 29512 64202275
Red cell distribution width decreased 33.19 13.70 31 266914 1062 64230725
Chromaturia 33.03 13.70 27 266918 22584 64209203
Hyperthyroidism 32.96 13.70 17 266928 18162 64213625
Intestinal polyp 32.93 13.70 38 266907 1673 64230114
Pulmonary haemorrhage 32.93 13.70 7 266938 13102 64218685
Enthesopathy 32.73 13.70 101 266844 9537 64222250
Nail disorder 32.72 13.70 94 266851 8530 64223257
Dementia 32.63 13.70 23 266922 20743 64211044
Escherichia infection 32.62 13.70 11 266934 15157 64216630
Schizophrenia 32.44 13.70 4 266941 11164 64220623
Electrocardiogram abnormal 32.26 13.70 8 266937 13473 64218314
Pulmonary toxicity 32.18 13.70 93 266852 8468 64223319
Glycosylated haemoglobin increased 32.12 13.70 13 266932 16006 64215781
Failure to thrive 32.07 13.70 3 266942 10401 64221386
Dislocation of vertebra 31.92 13.70 51 266894 3073 64228714
Eczema 31.77 13.70 46 266899 29674 64202113
Hemiplegia 31.70 13.70 7 266938 12761 64219026
Maternal exposure timing unspecified 31.60 13.70 47 266898 2660 64229127
Rash maculo-papular 31.51 13.70 95 266850 46931 64184856
Staphylococcal infection 31.43 13.70 106 266839 50572 64181215
Polyuria 31.25 13.70 7 266938 12636 64219151
Thyroid disorder 31.23 13.70 113 266832 11579 64220208
Rales 31.13 13.70 12 266933 15217 64216570
Prosthesis user 31.13 13.70 12 266933 70 64231717
Atrioventricular block 31.04 13.70 6 266939 12009 64219778
Neutrophil count increased 31.02 13.70 35 266910 25139 64206648
Angina pectoris 30.98 13.70 90 266855 44991 64186796
Pathogen resistance 30.89 13.70 7 266938 12536 64219251
Atrioventricular block first degree 30.80 13.70 4 266941 10730 64221057
Urine output decreased 30.53 13.70 15 266930 16477 64215310
Lung infiltration 30.44 13.70 25 266920 20864 64210923
Posterior reversible encephalopathy syndrome 30.41 13.70 30 266915 22916 64208871
Adverse reaction 30.35 13.70 85 266860 7602 64224185
Injection site warmth 30.31 13.70 9 266936 13453 64218334
Hypotonia 30.27 13.70 5 266940 11207 64220580
Cyst 30.25 13.70 114 266831 11913 64219874
Device occlusion 30.18 13.70 3 266942 9910 64221877
Pruritus 30.10 13.70 1581 265364 310819 63920968
Cardiac failure acute 30.06 13.70 15 266930 16329 64215458
Metastases to liver 29.81 13.70 33 266912 23908 64207879
Cerebral infarction 29.65 13.70 80 266865 40964 64190823
Muscle spasms 29.63 13.70 408 266537 140615 64091172
Faecaloma 29.47 13.70 3 266942 9725 64222062
Dermatitis exfoliative 29.36 13.70 4 266941 10348 64221439
Incontinence 29.24 13.70 7 266938 12074 64219713
Malnutrition 28.99 13.70 22 266923 19103 64212684
Intestinal perforation 28.97 13.70 133 266812 15180 64216607
Drug resistance 28.83 13.70 64 266881 35038 64196749
Eyelid ptosis 28.70 13.70 3 266942 9522 64222265
Arteriosclerosis 28.56 13.70 15 266930 15862 64215925
Hypoalbuminaemia 28.54 13.70 19 266926 17655 64214132
Pruritus allergic 28.44 13.70 26 266919 866 64230921
Fracture delayed union 28.42 13.70 38 266907 1947 64229840
Vaginal haemorrhage 28.38 13.70 23 266922 19321 64212466
Joint dislocation 28.28 13.70 108 266837 11357 64220430
Rash papular 28.17 13.70 18 266927 17095 64214692
Bundle branch block left 28.17 13.70 4 266941 10030 64221757
Wrist deformity 28.16 13.70 36 266909 1764 64230023
Thrombotic microangiopathy 28.14 13.70 17 266928 16638 64215149
Brachiocephalic artery stenosis 28.06 13.70 9 266936 27 64231760
Bladder transitional cell carcinoma 27.99 13.70 41 266904 2289 64229498
Renal disorder 27.81 13.70 66 266879 35299 64196488
Device related infection 27.55 13.70 53 266892 30573 64201214
Hyperthermia 27.52 13.70 15 266930 15535 64216252
Cold sweat 27.52 13.70 17 266928 16438 64215349
Eye swelling 27.43 13.70 31 266914 22250 64209537
Blood fibrinogen decreased 27.42 13.70 32 266913 1426 64230361
Ligament sprain 27.41 13.70 103 266842 10749 64221038
Smear cervix abnormal 27.40 13.70 41 266904 2333 64229454
Injection site swelling 27.38 13.70 84 266861 41269 64190518
Skin laceration 27.33 13.70 184 266761 24233 64207554
Incorrect product administration duration 27.14 13.70 4 266941 9754 64222033
Congestive cardiomyopathy 27.08 13.70 5 266940 10339 64221448
Panic attack 27.07 13.70 28 266917 20925 64210862
Thermal burn 27.05 13.70 69 266876 5837 64225950
Bunion operation 27.03 13.70 24 266921 769 64231018
Sudden death 26.95 13.70 26 266919 20070 64211717
Eosinophilia 26.91 13.70 75 266870 38001 64193786
Malaise 26.87 13.70 1353 265592 394894 63836893
Tongue disorder 26.74 13.70 110 266835 11970 64219817
Blood loss anaemia 26.70 13.70 12 266933 13880 64217907
Retching 26.59 13.70 15 266930 15241 64216546
Wound infection 26.58 13.70 127 266818 14737 64217050
Therapeutic response unexpected 26.49 13.70 19 266926 16982 64214805
Oedema 26.37 13.70 248 266697 91687 64140100
Ischaemic stroke 26.33 13.70 50 266895 28985 64202802
Ankle arthroplasty 26.18 13.70 25 266920 881 64230906
Neck pain 25.98 13.70 378 266567 61155 64170632
Gait inability 25.95 13.70 279 266666 42089 64189698
Purpura 25.94 13.70 20 266925 17226 64214561
Liver disorder 25.89 13.70 336 266609 53015 64178772
Oliguria 25.88 13.70 14 266931 14562 64217225
Injection site pruritus 25.64 13.70 76 266869 37750 64194037
Influenza like illness 25.58 13.70 150 266795 61552 64170235
Dermatitis bullous 25.48 13.70 9 266936 12045 64219742
Hepatitis C 25.48 13.70 7 266938 11008 64220779
Skin reaction 25.42 13.70 110 266835 12242 64219545
Cholecystitis chronic 25.39 13.70 4 266941 9283 64222504
Gastric haemorrhage 25.36 13.70 12 266933 13469 64218318
Anger 25.31 13.70 17 266928 15724 64216063
Gastric infection 25.28 13.70 47 266898 3201 64228586
Personality change 25.15 13.70 3 266942 8590 64223197
Acute pulmonary oedema 24.72 13.70 11 266934 12798 64218989
Amylase increased 24.68 13.70 5 266940 9680 64222107
Epigastric discomfort 24.65 13.70 73 266872 6738 64225049
Complication associated with device 24.64 13.70 16 266929 15064 64216723
Nystagmus 24.58 13.70 4 266941 9064 64222723
Hepatocellular injury 24.52 13.70 100 266845 45135 64186652
Cardiac failure chronic 24.48 13.70 4 266941 9037 64222750
Nephropathy 24.37 13.70 3 266942 8383 64223404
Ulcerative keratitis 24.33 13.70 45 266900 3052 64228735
Cough 24.24 13.70 1013 265932 301135 63930652
Torus fracture 24.17 13.70 10 266935 72 64231715
Polyneuropathy 24.14 13.70 28 266917 19866 64211921
Haemodynamic instability 24.12 13.70 16 266929 14896 64216891
Skin burning sensation 23.97 13.70 7 266938 10576 64221211
Device leakage 23.91 13.70 3 266942 8263 64223524
Intervertebral disc compression 23.87 13.70 25 266920 986 64230801
Metastases to lung 23.86 13.70 17 266928 15247 64216540
Coronary artery occlusion 23.72 13.70 14 266931 13877 64217910
Pancreatitis acute 23.70 13.70 94 266851 42761 64189026
Neck surgery 23.49 13.70 30 266915 1469 64230318
Spinal stenosis 23.46 13.70 117 266828 13814 64217973
Tuberculin test positive 23.38 13.70 44 266901 3024 64228763
Respiratory acidosis 23.29 13.70 6 266939 9849 64221938
Squamous cell carcinoma of skin 23.23 13.70 10 266935 11866 64219921
Proteinuria 23.22 13.70 50 266895 27673 64204114
Splenomegaly 23.21 13.70 24 266921 17937 64213850
Dry eye 23.14 13.70 202 266743 28817 64202970
Electrocardiogram QRS complex prolonged 23.09 13.70 5 266940 9239 64222548
Diabetic eye disease 23.08 13.70 12 266933 153 64231634
Muscle atrophy 22.95 13.70 6 266939 9752 64222035
Dizziness postural 22.93 13.70 6 266939 9746 64222041
Tumour lysis syndrome 22.91 13.70 28 266917 19412 64212375
Eructation 22.90 13.70 5 266940 9186 64222601
Cytokine storm 22.88 13.70 23 266922 864 64230923
Androgenetic alopecia 22.88 13.70 12 266933 156 64231631
Flank pain 22.83 13.70 20 266925 16169 64215618
Osteonecrosis 22.75 13.70 52 266893 28177 64203610
Amyotrophic lateral sclerosis 22.73 13.70 31 266914 1619 64230168
Orthopnoea 22.69 13.70 5 266940 9129 64222658
Multiple sclerosis 22.62 13.70 27 266918 18914 64212873
Odynophagia 22.54 13.70 6 266939 9635 64222152
Pemphigoid 22.30 13.70 13 266932 12973 64218814
Autoimmune hepatitis 22.24 13.70 7 266938 10077 64221710
Pain of skin 22.21 13.70 6 266939 9541 64222246
Tendonitis 22.20 13.70 152 266793 20130 64211657
Immune reconstitution inflammatory syndrome 22.11 13.70 12 266933 12458 64219329
Deafness 22.11 13.70 26 266919 18333 64213454
Foot operation 22.08 13.70 52 266893 4183 64227604
Oral candidiasis 21.92 13.70 39 266906 23173 64208614
Refusal of treatment by patient 21.90 13.70 4 266941 8335 64223452
Cerebral ischaemia 21.82 13.70 7 266938 9955 64221832
Joint ankylosis 21.81 13.70 21 266924 748 64231039
Impaired gastric emptying 21.77 13.70 83 266862 8721 64223066
Rash pruritic 21.68 13.70 346 266599 57058 64174729
Hyperammonaemia 21.62 13.70 7 266938 9897 64221890
Cytomegalovirus infection 21.60 13.70 80 266865 37119 64194668
Mean cell volume decreased 21.59 13.70 46 266899 3460 64228327
Erythema multiforme 21.42 13.70 20 266925 15681 64216106
Drug-induced liver injury 21.28 13.70 113 266832 47530 64184257
Haemorrhoids 21.19 13.70 42 266903 23959 64207828
Bundle branch block right 21.14 13.70 8 266937 10261 64221526
Pneumonitis 21.11 13.70 122 266823 50243 64181544
Interleukin level increased 21.05 13.70 16 266929 410 64231377
Cachexia 21.05 13.70 6 266939 9211 64222576
Squamous cell carcinoma 20.96 13.70 16 266929 13853 64217934
Hyperuricaemia 20.88 13.70 8 266937 10183 64221604
Immune thrombocytopenia 20.78 13.70 19 266926 15047 64216740
Wrist surgery 20.75 13.70 20 266925 713 64231074
Metabolic encephalopathy 20.75 13.70 4 266941 8021 64223766
Abnormal loss of weight 20.66 13.70 3 266942 7397 64224390
Post procedural haemorrhage 20.57 13.70 13 266932 12418 64219369
Thirst 20.50 13.70 17 266928 14120 64217667
Asphyxia 20.46 13.70 7 266938 9559 64222228
Partial seizures 20.31 13.70 3 266942 7304 64224483
Left ventricular hypertrophy 20.26 13.70 7 266938 9499 64222288
Respiratory syncytial virus infection 20.17 13.70 3 266942 7265 64224522
Protein urine present 20.14 13.70 6 266939 8950 64222837
Electrocardiogram ST segment elevation 20.13 13.70 3 266942 7256 64224531
Obesity 20.13 13.70 150 266795 20412 64211375
Haemorrhagic stroke 20.08 13.70 8 266937 9943 64221844
Paraesthesia oral 20.04 13.70 15 266930 13116 64218671
Major depression 19.99 13.70 4 266941 7812 64223975
Bronchospasm 19.96 13.70 37 266908 21645 64210142
Hepatic function abnormal 19.74 13.70 375 266570 63938 64167849
Arthritis infective 19.68 13.70 69 266876 6961 64224826
Device difficult to use 19.57 13.70 8 266937 9790 64221997
Bronchitis 19.56 13.70 589 266356 108154 64123633
Metabolic disorder 19.56 13.70 4 266941 7693 64224094
Limb discomfort 19.55 13.70 185 266760 26990 64204797
Eye movement disorder 19.46 13.70 3 266942 7076 64224711
Adenoiditis 19.38 13.70 7 266938 33 64231754
Pulmonary alveolar haemorrhage 19.37 13.70 8 266937 9730 64222057
Paralysis 19.36 13.70 12 266933 11583 64220204
Tendon disorder 19.35 13.70 64 266881 6268 64225519
Catatonia 19.28 13.70 4 266941 7616 64224171
Blood uric acid increased 19.23 13.70 5 266940 8158 64223629
Aplasia pure red cell 19.22 13.70 3 266942 7011 64224776
Fear of injection 19.19 13.70 61 266884 5851 64225936
Gastropleural fistula 19.06 13.70 8 266937 60 64231727
Ankylosing spondylitis 19.04 13.70 76 266869 8158 64223629
Vaginal haematoma 18.93 13.70 10 266935 132 64231655
Abortion spontaneous 18.93 13.70 48 266897 25095 64206692
Underdose 18.91 13.70 50 266895 25779 64206008
Lipase increased 18.89 13.70 19 266926 14383 64217404
Central nervous system lesion 18.78 13.70 13 266932 11836 64219951
Eyelid oedema 18.77 13.70 14 266931 12265 64219522
Post transplant lymphoproliferative disorder 18.73 13.70 8 266937 9536 64222251
COVID-19 18.56 13.70 176 266769 64964 64166823
Brain injury 18.54 13.70 9 266936 9956 64221831
Disability assessment scale score decreased 18.54 13.70 5 266940 6 64231781
Bone swelling 18.51 13.70 24 266921 1193 64230594
Adjustment disorder with depressed mood 18.43 13.70 35 266910 2422 64229365
Urosepsis 18.37 13.70 40 266905 22054 64209733
Disseminated large cell lymphoma 18.31 13.70 8 266937 67 64231720
Ileus paralytic 18.28 13.70 6 266939 8409 64223378
Pustular psoriasis 18.26 13.70 48 266897 4135 64227652
Breath sounds abnormal 18.24 13.70 13 266932 11656 64220131
Hepatocellular carcinoma 18.24 13.70 6 266939 8397 64223390
Infected skin ulcer 18.23 13.70 39 266906 2941 64228846
Nervous system disorder 18.20 13.70 43 266902 23035 64208752
Infectious pleural effusion 18.14 13.70 38 266907 2824 64228963
Bladder prolapse 18.14 13.70 23 266922 1118 64230669
Normochromic normocytic anaemia 18.02 13.70 3 266942 6687 64225100
Thiopurine methyltransferase decreased 17.91 13.70 13 266932 310 64231477
Extrasystoles 17.90 13.70 3 266942 6655 64225132
Petechiae 17.85 13.70 31 266914 18595 64213192
Myositis 17.85 13.70 25 266920 16352 64215435
Skin discolouration 17.84 13.70 80 266865 35175 64196612
Nerve injury 17.82 13.70 71 266874 7614 64224173
Localised oedema 17.74 13.70 4 266941 7187 64224600
Mental fatigue 17.73 13.70 15 266930 450 64231337
Cerebral haematoma 17.71 13.70 4 266941 7181 64224606
Abscess limb 17.71 13.70 61 266884 6100 64225687
Exercise tolerance decreased 17.64 13.70 5 266940 7705 64224082
Gout 17.62 13.70 39 266906 21374 64210413
Hyperreflexia 17.58 13.70 4 266941 7144 64224643
Ventricular hypertrophy 17.38 13.70 3 266942 6513 64225274
Injection site inflammation 17.28 13.70 40 266905 3181 64228606
Retinitis 17.27 13.70 31 266914 2054 64229733
Nephrotic syndrome 17.26 13.70 9 266936 9558 64222229
Hepatomegaly 17.20 13.70 27 266918 16855 64214932
Generalised oedema 17.14 13.70 38 266907 20815 64210972
Peritonitis bacterial 17.09 13.70 8 266937 9035 64222752
Infected varicose vein 17.01 13.70 6 266939 26 64231761
Ammonia increased 16.97 13.70 4 266941 6973 64224814
Dermatitis contact 16.95 13.70 8 266937 8992 64222795
Reactive gastropathy 16.95 13.70 14 266931 406 64231381
Allergic oedema 16.86 13.70 18 266927 726 64231061
Diaphragmatic rupture 16.83 13.70 11 266934 220 64231567
Injection site urticaria 16.77 13.70 13 266932 11168 64220619
Aphthous ulcer 16.76 13.70 101 266844 12805 64218982
Live birth 16.73 13.70 91 266854 11113 64220674
Cystitis haemorrhagic 16.71 13.70 6 266939 7950 64223837
Hiatus hernia 16.71 13.70 36 266909 19921 64211866
Hypoaesthesia oral 16.70 13.70 14 266931 11566 64220221
Mean cell haemoglobin decreased 16.69 13.70 46 266899 4076 64227711
Abscess rupture 16.68 13.70 12 266933 282 64231505
Periorbital oedema 16.61 13.70 5 266940 7409 64224378
Bronchitis viral 16.59 13.70 21 266924 1019 64230768
Retinal haemorrhage 16.56 13.70 5 266940 7393 64224394
Lower gastrointestinal haemorrhage 16.51 13.70 20 266925 13919 64217868
Feeling jittery 16.42 13.70 12 266933 10623 64221164
Bacille Calmette-Guerin scar reactivation 16.32 13.70 6 266939 30 64231757
Dysstasia 16.21 13.70 46 266899 23169 64208618
Pulmonary congestion 16.17 13.70 48 266897 23832 64207955
Tooth abscess 15.96 13.70 105 266840 13721 64218066
Product storage error 15.89 13.70 19 266926 13299 64218488
Neurotoxicity 15.87 13.70 59 266886 27345 64204442
Acidosis 15.83 13.70 31 266914 17764 64214023
Multiple system atrophy 15.82 13.70 13 266932 374 64231413
Decreased activity 15.81 13.70 5 266940 7175 64224612
Human anti-human antibody test 15.79 13.70 13 266932 375 64231412
Cardiac tamponade 15.77 13.70 7 266938 8157 64223630
Rheumatoid factor increased 15.70 13.70 24 266921 1392 64230395
Blood thyroid stimulating hormone increased 15.70 13.70 6 266939 7648 64224139
Pleurisy 15.62 13.70 78 266867 9213 64222574
Mouth ulceration 15.60 13.70 204 266741 32240 64199547
Gynaecomastia 15.55 13.70 3 266942 6013 64225774
Swelling face 15.55 13.70 163 266782 59003 64172784
Thinking abnormal 15.44 13.70 15 266930 11541 64220246
Thrombotic thrombocytopenic purpura 15.44 13.70 3 266942 5981 64225806
Taste disorder 15.42 13.70 10 266935 9423 64222364
Laryngitis 15.41 13.70 88 266857 10943 64220844
Eye haemorrhage 15.37 13.70 72 266873 8288 64223499
Oesophageal candidiasis 15.29 13.70 7 266938 8010 64223777
Osteosclerosis 15.22 13.70 40 266905 3446 64228341
Shock haemorrhagic 15.15 13.70 29 266916 16762 64215025
Anticipatory anxiety 15.09 13.70 11 266934 264 64231523
Glucose tolerance impaired 15.08 13.70 4 266941 6439 64225348
Aplasia 15.03 13.70 5 266940 6948 64224839
Blood triglycerides increased 15.00 13.70 35 266910 18831 64212956
Abnormal faeces 14.98 13.70 3 266942 5856 64225931
Intervertebral disc space narrowing 14.95 13.70 23 266922 1341 64230446
Eosinophil count increased 14.93 13.70 22 266923 14090 64217697
Hepatic steatosis 14.93 13.70 195 266750 30812 64200975
BK virus infection 14.89 13.70 6 266939 7406 64224381
Hyperbilirubinaemia 14.81 13.70 42 266903 21163 64210624
Duodenal ulcer 14.79 13.70 23 266922 14412 64217375
Effusion 14.72 13.70 28 266917 1940 64229847
Acute graft versus host disease in skin 14.69 13.70 5 266940 6850 64224937
Disseminated mucormycosis 14.65 13.70 14 266931 494 64231293
Urine analysis abnormal 14.61 13.70 3 266942 5753 64226034
Growth failure 14.47 13.70 10 266935 220 64231567
Cerebral atrophy 14.47 13.70 6 266939 7279 64224508
Blood phosphorus decreased 14.42 13.70 3 266942 5702 64226085
Post procedural complication 14.40 13.70 43 266902 21310 64210477
Hepatic enzyme abnormal 14.40 13.70 55 266890 5784 64226003
Migraine 14.38 13.70 178 266767 62499 64169288
Premature delivery 14.37 13.70 35 266910 18554 64213233
Red blood cell sedimentation rate decreased 14.35 13.70 10 266935 223 64231564
Oesophageal ulcer 14.26 13.70 4 266941 6206 64225581
Stress at work 14.26 13.70 19 266926 970 64230817
Rheumatoid vasculitis 14.25 13.70 13 266932 432 64231355
Hypercapnia 14.24 13.70 7 266938 7687 64224100
Rheumatoid factor 14.08 13.70 8 266937 123 64231664
Rhinovirus infection 14.07 13.70 4 266941 6152 64225635
Myocarditis 14.05 13.70 31 266914 17012 64214775
Hypoxic-ischaemic encephalopathy 14.03 13.70 6 266939 7146 64224641
Premature labour 14.00 13.70 7 266938 7613 64224174
Injection site induration 13.89 13.70 10 266935 8922 64222865
Shoulder arthroplasty 13.84 13.70 33 266912 2676 64229111
Blood glucose abnormal 13.84 13.70 10 266935 8903 64222884
Sensory loss 13.82 13.70 13 266932 10156 64221631
Blood urine present 13.81 13.70 35 266910 18305 64213482
Affective disorder 13.76 13.70 5 266940 6575 64225212
Endodontic procedure 13.75 13.70 30 266915 2293 64229494
Excessive cerumen production 13.73 13.70 14 266931 535 64231252
Hypocomplementaemia 13.73 13.70 9 266936 181 64231606

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000190478 Interleukin 6 Receptor Antagonists
FDA EPC N0000190480 Interleukin-6 Receptor Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Castleman's disease indication 207036003 DOID:0111157
Still's disease indication 410794002
Juvenile rheumatoid arthritis indication 410795001
Giant cell arteritis indication 414341000 DOID:13375
Cytokine release syndrome induced by tumor-specific T-cell infusion therapy indication 710027002
Pneumonia caused by Severe acute respiratory syndrome coronavirus 2 indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-6 receptor Membrane receptor ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D02596 KEGG_DRUG
4029705 VUID
N0000180629 NUI
4029705 VANDF
CHEMBL1237022 ChEMBL_ID
C502936 MESH_SUPPLEMENTAL_RECORD_UI
6881 IUPHAR_LIGAND_ID
8394 INN_ID
DB06273 DRUGBANK_ID
I031V2H011 UNII
10150081 PUBCHEM_CID
612865 RXNORM
169600 MMSL
26778 MMSL
d07496 MMSL
444648007 SNOMEDCT_US
444649004 SNOMEDCT_US
C1609165 UMLSCUI
013198 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 180 mg SUBCUTANEOUS BLA 33 sections