| Stem definition | Drug id | CAS RN |
|---|---|---|
| humanized origin | 4933 | 375823-41-9 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
a humanised anti-interleukin-6 receptor monoclonal antibody
|
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | P |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 16, 2009 | EMA | ||
| Jan. 8, 2010 | FDA | GENENTECH | |
| March 6, 2008 | PMDA |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 7122.58 | 14.21 | 8702 | 286678 | 305829 | 52747857 |
| Drug ineffective | 6027.69 | 14.21 | 13594 | 281786 | 803651 | 52250035 |
| Contraindicated product administered | 4090.79 | 14.21 | 4365 | 291015 | 131264 | 52922422 |
| Joint swelling | 3288.44 | 14.21 | 5165 | 290215 | 229473 | 52824213 |
| Treatment failure | 3129.33 | 14.21 | 3700 | 291680 | 124703 | 52928983 |
| Drug intolerance | 3126.36 | 14.21 | 4700 | 290680 | 200793 | 52852893 |
| Synovitis | 3025.84 | 14.21 | 3344 | 292036 | 104549 | 52949137 |
| Arthropathy | 2230.25 | 14.21 | 3293 | 292087 | 138160 | 52915526 |
| Therapeutic product effect decreased | 2064.09 | 14.21 | 2983 | 292397 | 122672 | 52931014 |
| Pemphigus | 1996.22 | 14.21 | 2662 | 292718 | 101369 | 52952317 |
| Systemic lupus erythematosus | 1820.13 | 14.21 | 2810 | 292570 | 122604 | 52931082 |
| Swelling | 1603.48 | 14.21 | 3372 | 292008 | 187733 | 52865953 |
| Glossodynia | 1532.03 | 14.21 | 2302 | 293078 | 97989 | 52955697 |
| Pain | 1478.79 | 14.21 | 6794 | 288586 | 581604 | 52472082 |
| Arthralgia | 1435.85 | 14.21 | 5504 | 289876 | 434279 | 52619407 |
| Hand deformity | 1433.99 | 14.21 | 2043 | 293337 | 82806 | 52970880 |
| Abdominal discomfort | 1269.91 | 14.21 | 3365 | 292015 | 217697 | 52835989 |
| Rheumatoid factor positive | 1116.49 | 14.21 | 1256 | 294124 | 39942 | 53013744 |
| Hepatic enzyme increased | 1102.92 | 14.21 | 2266 | 293114 | 123929 | 52929757 |
| Alopecia | 1062.19 | 14.21 | 3278 | 292102 | 231305 | 52822381 |
| Hypersensitivity | 1036.80 | 14.21 | 3032 | 292348 | 207633 | 52846053 |
| Infusion related reaction | 1029.98 | 14.21 | 2504 | 292876 | 153453 | 52900233 |
| Wound | 940.27 | 14.21 | 1760 | 293620 | 89797 | 52963889 |
| Death | 919.03 | 14.21 | 415 | 294965 | 356817 | 52696869 |
| C-reactive protein abnormal | 914.93 | 14.21 | 909 | 294471 | 24961 | 53028725 |
| Anti-cyclic citrullinated peptide antibody positive | 891.71 | 14.21 | 1326 | 294054 | 55846 | 52997840 |
| Acute kidney injury | 843.92 | 14.21 | 187 | 295193 | 253681 | 52800005 |
| Musculoskeletal stiffness | 835.73 | 14.21 | 2001 | 293379 | 121367 | 52932319 |
| Rash | 814.23 | 14.21 | 4719 | 290661 | 441472 | 52612214 |
| Toxicity to various agents | 806.24 | 14.21 | 126 | 295254 | 219472 | 52834214 |
| Drug interaction | 778.22 | 14.21 | 138 | 295242 | 219191 | 52834495 |
| Red blood cell sedimentation rate abnormal | 769.88 | 14.21 | 662 | 294718 | 15027 | 53038659 |
| Peripheral swelling | 747.29 | 14.21 | 2673 | 292707 | 203435 | 52850251 |
| Lower respiratory tract infection | 731.84 | 14.21 | 1580 | 293800 | 89401 | 52964285 |
| Infection | 725.75 | 14.21 | 2349 | 293031 | 169856 | 52883830 |
| Pericarditis | 712.61 | 14.21 | 1279 | 294101 | 63127 | 52990559 |
| Loss of personal independence in daily activities | 706.47 | 14.21 | 1334 | 294046 | 68481 | 52985205 |
| Anaemia | 657.43 | 14.21 | 357 | 295023 | 276361 | 52777325 |
| Discomfort | 580.10 | 14.21 | 1486 | 293894 | 93986 | 52959700 |
| Ill-defined disorder | 571.46 | 14.21 | 1001 | 294379 | 48443 | 53005243 |
| Product use issue | 566.16 | 14.21 | 1880 | 293500 | 137704 | 52915982 |
| Dehydration | 545.43 | 14.21 | 131 | 295249 | 168279 | 52885407 |
| Muscle injury | 506.95 | 14.21 | 720 | 294660 | 29046 | 53024640 |
| Folliculitis | 505.03 | 14.21 | 743 | 294637 | 30966 | 53022720 |
| Red blood cell sedimentation rate increased | 503.64 | 14.21 | 696 | 294684 | 27361 | 53026325 |
| Hyponatraemia | 494.22 | 14.21 | 26 | 295354 | 108581 | 52945105 |
| Decreased appetite | 492.14 | 14.21 | 290 | 295090 | 214684 | 52839002 |
| Impaired healing | 484.32 | 14.21 | 1087 | 294293 | 63118 | 52990568 |
| Drug hypersensitivity | 478.51 | 14.21 | 2800 | 292580 | 262442 | 52791244 |
| Therapeutic product effect incomplete | 456.02 | 14.21 | 1327 | 294053 | 90457 | 52963229 |
| Febrile neutropenia | 451.01 | 14.21 | 34 | 295346 | 104902 | 52948784 |
| Dizziness | 444.01 | 14.21 | 869 | 294511 | 371390 | 52682296 |
| Maternal exposure during pregnancy | 439.91 | 14.21 | 1867 | 293513 | 153772 | 52899914 |
| Product dose omission issue | 432.21 | 14.21 | 263 | 295117 | 191357 | 52862329 |
| Nausea | 429.46 | 14.21 | 2449 | 292931 | 753642 | 52300044 |
| Intentional product use issue | 416.24 | 14.21 | 1105 | 294275 | 71389 | 52982297 |
| Anxiety | 403.36 | 14.21 | 300 | 295080 | 196404 | 52857282 |
| Seizure | 397.73 | 14.21 | 112 | 295268 | 129397 | 52924289 |
| C-reactive protein increased | 390.99 | 14.21 | 1036 | 294344 | 66850 | 52986836 |
| Constipation | 389.86 | 14.21 | 316 | 295064 | 198096 | 52855590 |
| Bone erosion | 385.23 | 14.21 | 387 | 294993 | 10765 | 53042921 |
| Tremor | 381.95 | 14.21 | 111 | 295269 | 125625 | 52928061 |
| Helicobacter infection | 380.78 | 14.21 | 735 | 294645 | 38334 | 53015352 |
| Nasopharyngitis | 374.02 | 14.21 | 2072 | 293308 | 190223 | 52863463 |
| Irritable bowel syndrome | 372.79 | 14.21 | 777 | 294603 | 42855 | 53010831 |
| Duodenal ulcer perforation | 365.28 | 14.21 | 680 | 294700 | 34503 | 53019183 |
| Overdose | 360.28 | 14.21 | 78 | 295302 | 107658 | 52946028 |
| Off label use | 360.19 | 14.21 | 4094 | 291286 | 468118 | 52585568 |
| Dyspnoea | 359.68 | 14.21 | 1849 | 293531 | 584383 | 52469303 |
| Diarrhoea | 359.00 | 14.21 | 2018 | 293362 | 623528 | 52430158 |
| Intentional overdose | 354.87 | 14.21 | 3 | 295377 | 67202 | 52986484 |
| Condition aggravated | 354.30 | 14.21 | 2833 | 292547 | 294301 | 52759385 |
| Knee arthroplasty | 343.76 | 14.21 | 645 | 294735 | 32924 | 53020762 |
| Rheumatoid nodule | 338.89 | 14.21 | 372 | 295008 | 11492 | 53042194 |
| Sleep disorder due to general medical condition, insomnia type | 334.76 | 14.21 | 533 | 294847 | 23816 | 53029870 |
| Injection site pain | 331.95 | 14.21 | 107 | 295273 | 113284 | 52940402 |
| Blood iron abnormal | 326.87 | 14.21 | 213 | 295167 | 3114 | 53050572 |
| Depression | 324.26 | 14.21 | 321 | 295059 | 182731 | 52870955 |
| Cardiac arrest | 316.90 | 14.21 | 66 | 295314 | 93601 | 52960085 |
| Renal failure | 314.30 | 14.21 | 131 | 295249 | 118321 | 52935365 |
| Sinusitis | 313.56 | 14.21 | 1795 | 293585 | 166769 | 52886917 |
| Somnolence | 310.11 | 14.21 | 283 | 295097 | 167451 | 52886235 |
| Asthenia | 308.40 | 14.21 | 930 | 294450 | 342660 | 52711026 |
| Hypotension | 306.10 | 14.21 | 589 | 294791 | 253487 | 52800199 |
| Cardiac failure congestive | 300.44 | 14.21 | 72 | 295308 | 92685 | 52961001 |
| Blister | 298.94 | 14.21 | 1038 | 294342 | 77715 | 52975971 |
| Joint stiffness | 289.32 | 14.21 | 565 | 294815 | 29718 | 53023968 |
| Thrombocytopenia | 287.60 | 14.21 | 209 | 295171 | 138518 | 52915168 |
| Hypokalaemia | 286.19 | 14.21 | 89 | 295291 | 96428 | 52957258 |
| Hip arthroplasty | 284.84 | 14.21 | 535 | 294845 | 27327 | 53026359 |
| Bradycardia | 283.87 | 14.21 | 31 | 295349 | 71025 | 52982661 |
| Electrocardiogram QT prolonged | 278.86 | 14.21 | 7 | 295373 | 56396 | 52997290 |
| Muscle spasms | 278.23 | 14.21 | 204 | 295176 | 134591 | 52919095 |
| Vomiting | 273.84 | 14.21 | 1624 | 293756 | 495515 | 52558171 |
| Oedema peripheral | 266.74 | 14.21 | 332 | 295048 | 170455 | 52883231 |
| Tachycardia | 266.33 | 14.21 | 133 | 295247 | 108079 | 52945607 |
| Neuropathy peripheral | 265.98 | 14.21 | 119 | 295261 | 103068 | 52950618 |
| Suicide attempt | 264.32 | 14.21 | 14 | 295366 | 58154 | 52995532 |
| Mobility decreased | 263.63 | 14.21 | 975 | 294405 | 75296 | 52978390 |
| Haemoglobin decreased | 261.78 | 14.21 | 225 | 295155 | 137082 | 52916604 |
| Skin ulcer | 260.58 | 14.21 | 601 | 294779 | 35518 | 53018168 |
| Hyperkalaemia | 256.52 | 14.21 | 10 | 295370 | 54246 | 52999440 |
| Inflammation | 256.18 | 14.21 | 797 | 294583 | 56339 | 52997347 |
| Hypoglycaemia | 251.03 | 14.21 | 20 | 295360 | 58993 | 52994693 |
| Feeling abnormal | 242.13 | 14.21 | 235 | 295145 | 135066 | 52918620 |
| Cardio-respiratory arrest | 241.55 | 14.21 | 23 | 295357 | 58735 | 52994951 |
| Malignant neoplasm progression | 238.72 | 14.21 | 52 | 295328 | 71489 | 52982197 |
| Osteoporosis | 237.59 | 14.21 | 679 | 294701 | 45781 | 53007905 |
| Abdominal pain | 234.93 | 14.21 | 685 | 294695 | 255218 | 52798468 |
| Respiratory failure | 232.02 | 14.21 | 134 | 295246 | 100378 | 52953308 |
| Atrial fibrillation | 231.66 | 14.21 | 168 | 295212 | 111484 | 52942202 |
| Arthritis | 231.62 | 14.21 | 1028 | 294352 | 86270 | 52967416 |
| Rheumatic fever | 229.64 | 14.21 | 315 | 295065 | 12289 | 53041397 |
| Plasma cell myeloma | 229.17 | 14.21 | 8 | 295372 | 47866 | 53005820 |
| Balance disorder | 225.25 | 14.21 | 63 | 295317 | 73144 | 52980542 |
| Panniculitis | 224.88 | 14.21 | 246 | 295134 | 7568 | 53046118 |
| Coma | 222.94 | 14.21 | 37 | 295343 | 61746 | 52991940 |
| Wrong technique in product usage process | 221.02 | 14.21 | 34 | 295346 | 59998 | 52993688 |
| Juvenile idiopathic arthritis | 220.08 | 14.21 | 190 | 295190 | 4334 | 53049352 |
| Depressed level of consciousness | 219.31 | 14.21 | 23 | 295357 | 54405 | 52999281 |
| Vision blurred | 218.61 | 14.21 | 100 | 295280 | 85504 | 52968182 |
| Granuloma skin | 216.07 | 14.21 | 199 | 295181 | 4955 | 53048731 |
| Rhabdomyolysis | 215.07 | 14.21 | 6 | 295374 | 43917 | 53009769 |
| Blood parathyroid hormone decreased | 210.44 | 14.21 | 215 | 295165 | 6103 | 53047583 |
| Pulmonary embolism | 209.16 | 14.21 | 195 | 295185 | 114247 | 52939439 |
| Sleep disorder | 207.98 | 14.21 | 758 | 294622 | 58112 | 52995574 |
| Gastrointestinal haemorrhage | 206.44 | 14.21 | 93 | 295287 | 80237 | 52973449 |
| Deformity | 205.97 | 14.21 | 237 | 295143 | 7717 | 53045969 |
| Blood cholesterol increased | 205.88 | 14.21 | 704 | 294676 | 52285 | 53001401 |
| Coeliac disease | 205.83 | 14.21 | 248 | 295132 | 8487 | 53045199 |
| Agitation | 205.23 | 14.21 | 38 | 295342 | 58588 | 52995098 |
| Cerebrovascular accident | 200.85 | 14.21 | 172 | 295208 | 105002 | 52948684 |
| Gastrooesophageal reflux disease | 199.79 | 14.21 | 104 | 295276 | 82559 | 52971127 |
| Gastrointestinal disorder | 198.75 | 14.21 | 1005 | 294375 | 88999 | 52964687 |
| Paraesthesia | 192.70 | 14.21 | 254 | 295126 | 127261 | 52926425 |
| Hallucination | 192.58 | 14.21 | 33 | 295347 | 53805 | 52999881 |
| Metabolic acidosis | 192.45 | 14.21 | 10 | 295370 | 42232 | 53011454 |
| Pancytopenia | 190.99 | 14.21 | 135 | 295245 | 90793 | 52962893 |
| Chest pain | 189.46 | 14.21 | 489 | 294891 | 189696 | 52863990 |
| Fall | 189.09 | 14.21 | 1186 | 294194 | 357254 | 52696432 |
| International normalised ratio increased | 187.84 | 14.21 | 22 | 295358 | 47739 | 53005947 |
| Chest discomfort | 185.58 | 14.21 | 167 | 295213 | 99528 | 52954158 |
| Urinary tract infection | 183.14 | 14.21 | 696 | 294684 | 239207 | 52814479 |
| Syncope | 181.91 | 14.21 | 211 | 295169 | 111782 | 52941904 |
| Swollen joint count increased | 181.79 | 14.21 | 266 | 295114 | 11024 | 53042662 |
| Cardiac failure | 179.58 | 14.21 | 128 | 295252 | 85716 | 52967970 |
| Inappropriate schedule of product administration | 178.31 | 14.21 | 96 | 295284 | 74782 | 52978904 |
| Dysphagia | 177.66 | 14.21 | 125 | 295255 | 84272 | 52969414 |
| Memory impairment | 173.89 | 14.21 | 129 | 295251 | 84628 | 52969058 |
| Cognitive disorder | 172.73 | 14.21 | 22 | 295358 | 44756 | 53008930 |
| Joint destruction | 172.33 | 14.21 | 148 | 295232 | 3351 | 53050335 |
| Disability assessment scale score increased | 171.62 | 14.21 | 127 | 295253 | 2302 | 53051384 |
| Weight increased | 168.62 | 14.21 | 1803 | 293577 | 202764 | 52850922 |
| Lactic acidosis | 166.06 | 14.21 | 10 | 295370 | 37243 | 53016443 |
| Chronic obstructive pulmonary disease | 164.44 | 14.21 | 66 | 295314 | 61007 | 52992679 |
| Lethargy | 164.01 | 14.21 | 47 | 295333 | 53713 | 52999973 |
| Hyperglycaemia | 161.33 | 14.21 | 17 | 295363 | 40067 | 53013619 |
| Musculoskeletal pain | 161.32 | 14.21 | 833 | 294547 | 74367 | 52979319 |
| Therapeutic response decreased | 160.89 | 14.21 | 604 | 294776 | 46965 | 53006721 |
| Hospitalisation | 156.41 | 14.21 | 100 | 295280 | 70912 | 52982774 |
| Unresponsive to stimuli | 155.20 | 14.21 | 7 | 295373 | 33419 | 53020267 |
| Disorientation | 155.10 | 14.21 | 18 | 295362 | 39341 | 53014345 |
| Ear pain | 154.93 | 14.21 | 437 | 294943 | 29236 | 53024450 |
| Hypoxia | 153.50 | 14.21 | 58 | 295322 | 55622 | 52998064 |
| Platelet count decreased | 151.67 | 14.21 | 227 | 295153 | 107872 | 52945814 |
| Dysarthria | 151.57 | 14.21 | 22 | 295358 | 40546 | 53013140 |
| Disturbance in attention | 150.96 | 14.21 | 10 | 295370 | 34373 | 53019313 |
| Diverticulitis | 148.22 | 14.21 | 486 | 294894 | 35315 | 53018371 |
| Pleural effusion | 148.07 | 14.21 | 163 | 295217 | 88416 | 52965270 |
| Suicidal ideation | 147.89 | 14.21 | 75 | 295305 | 60436 | 52993250 |
| Blood alkaline phosphatase increased | 146.51 | 14.21 | 26 | 295354 | 41336 | 53012350 |
| Deep vein thrombosis | 145.98 | 14.21 | 146 | 295234 | 82767 | 52970919 |
| Limb deformity | 145.83 | 14.21 | 141 | 295239 | 3738 | 53049948 |
| Respiratory arrest | 143.67 | 14.21 | 11 | 295369 | 33529 | 53020157 |
| Product quality issue | 143.26 | 14.21 | 18 | 295362 | 37005 | 53016681 |
| Neoplasm progression | 143.20 | 14.21 | 5 | 295375 | 29914 | 53023772 |
| Epistaxis | 142.98 | 14.21 | 103 | 295277 | 68607 | 52985079 |
| Stomatitis | 142.17 | 14.21 | 981 | 294399 | 97177 | 52956509 |
| Musculoskeletal deformity | 142.16 | 14.21 | 80 | 295300 | 881 | 53052805 |
| Blood glucose increased | 139.93 | 14.21 | 133 | 295247 | 77228 | 52976458 |
| Pulmonary fibrosis | 139.53 | 14.21 | 369 | 295011 | 23766 | 53029920 |
| Skin necrosis | 137.89 | 14.21 | 226 | 295154 | 10346 | 53043340 |
| Mental status changes | 137.74 | 14.21 | 26 | 295354 | 39545 | 53014141 |
| Myalgia | 137.71 | 14.21 | 337 | 295043 | 133154 | 52920532 |
| Pyrexia | 135.69 | 14.21 | 1503 | 293877 | 401690 | 52651996 |
| Palpitations | 134.97 | 14.21 | 224 | 295156 | 102124 | 52951562 |
| Sciatica | 133.98 | 14.21 | 340 | 295040 | 21353 | 53032333 |
| Hypophagia | 133.58 | 14.21 | 10 | 295370 | 31052 | 53022634 |
| Bronchitis chronic | 131.33 | 14.21 | 139 | 295241 | 4115 | 53049571 |
| Muscle spasticity | 131.04 | 14.21 | 299 | 295081 | 17539 | 53036147 |
| Incorrect dose administered | 129.72 | 14.21 | 60 | 295320 | 50985 | 53002701 |
| Dyskinesia | 129.41 | 14.21 | 13 | 295367 | 31820 | 53021866 |
| Drug tolerance decreased | 128.21 | 14.21 | 180 | 295200 | 7178 | 53046508 |
| No adverse event | 128.18 | 14.21 | 493 | 294887 | 38772 | 53014914 |
| Muscular weakness | 127.71 | 14.21 | 227 | 295153 | 100765 | 52952921 |
| Immobile | 127.59 | 14.21 | 151 | 295229 | 5069 | 53048617 |
| Coronary artery disease | 127.59 | 14.21 | 17 | 295363 | 33420 | 53020266 |
| Foot deformity | 127.38 | 14.21 | 303 | 295077 | 18265 | 53035421 |
| Disease progression | 127.17 | 14.21 | 231 | 295149 | 101689 | 52951997 |
| Injection site erythema | 127.08 | 14.21 | 144 | 295236 | 77105 | 52976581 |
| Blood potassium decreased | 125.98 | 14.21 | 34 | 295346 | 40426 | 53013260 |
| Emotional distress | 124.35 | 14.21 | 16 | 295364 | 32301 | 53021385 |
| Blood pressure systolic increased | 123.41 | 14.21 | 452 | 294928 | 34725 | 53018961 |
| Liver function test increased | 122.60 | 14.21 | 375 | 295005 | 26253 | 53027433 |
| Tenosynovitis | 122.31 | 14.21 | 207 | 295173 | 9732 | 53043954 |
| Pulmonary oedema | 121.99 | 14.21 | 73 | 295307 | 53650 | 53000036 |
| Osteonecrosis of jaw | 121.12 | 14.21 | 26 | 295354 | 36120 | 53017566 |
| Pneumonia aspiration | 120.54 | 14.21 | 22 | 295358 | 34279 | 53019407 |
| Generalised tonic-clonic seizure | 118.87 | 14.21 | 11 | 295369 | 28747 | 53024939 |
| Orthostatic hypotension | 118.76 | 14.21 | 13 | 295367 | 29740 | 53023946 |
| Neutropenia | 118.68 | 14.21 | 466 | 294914 | 158719 | 52894967 |
| Intentional self-injury | 118.36 | 14.21 | 5 | 295375 | 25279 | 53028407 |
| Ascites | 117.10 | 14.21 | 37 | 295343 | 39698 | 53013988 |
| Skin exfoliation | 116.81 | 14.21 | 28 | 295352 | 36055 | 53017631 |
| Body height below normal | 116.30 | 14.21 | 92 | 295288 | 1849 | 53051837 |
| Foetal exposure during pregnancy | 116.26 | 14.21 | 25 | 295355 | 34690 | 53018996 |
| Sedation | 115.86 | 14.21 | 14 | 295366 | 29661 | 53024025 |
| Oral mucosal exfoliation | 115.04 | 14.21 | 85 | 295295 | 1537 | 53052149 |
| Pneumonia | 113.91 | 14.21 | 1579 | 293801 | 405590 | 52648096 |
| Joint laxity | 113.41 | 14.21 | 98 | 295282 | 2238 | 53051448 |
| Dysgeusia | 112.97 | 14.21 | 48 | 295332 | 42883 | 53010803 |
| Irritability | 112.86 | 14.21 | 18 | 295362 | 30935 | 53022751 |
| Toxic epidermal necrolysis | 112.48 | 14.21 | 4 | 295376 | 23546 | 53030140 |
| Osteoarthritis | 112.01 | 14.21 | 721 | 294659 | 69765 | 52983921 |
| Blood pressure diastolic decreased | 111.83 | 14.21 | 271 | 295109 | 16532 | 53037154 |
| Aggression | 111.69 | 14.21 | 4 | 295376 | 23399 | 53030287 |
| Investigation abnormal | 111.06 | 14.21 | 77 | 295303 | 1254 | 53052432 |
| Mucosal inflammation | 110.73 | 14.21 | 49 | 295331 | 42735 | 53010951 |
| Blood pressure systolic abnormal | 110.33 | 14.21 | 165 | 295215 | 6974 | 53046712 |
| Depressed mood | 109.68 | 14.21 | 34 | 295346 | 36930 | 53016756 |
| Blood bilirubin increased | 109.42 | 14.21 | 31 | 295349 | 35699 | 53017987 |
| Fatigue | 108.39 | 14.21 | 5009 | 290371 | 725497 | 52328189 |
| Intentional product misuse | 108.15 | 14.21 | 70 | 295310 | 49322 | 53004364 |
| Delirium | 107.93 | 14.21 | 47 | 295333 | 41382 | 53012304 |
| Blood pressure diastolic abnormal | 107.44 | 14.21 | 182 | 295198 | 8563 | 53045123 |
| Psychotic disorder | 107.33 | 14.21 | 7 | 295373 | 24378 | 53029308 |
| Abnormal behaviour | 107.00 | 14.21 | 3 | 295377 | 21863 | 53031823 |
| Temperature regulation disorder | 106.65 | 14.21 | 124 | 295256 | 4083 | 53049603 |
| Blood pressure decreased | 106.56 | 14.21 | 111 | 295269 | 61758 | 52991928 |
| Fluid overload | 106.55 | 14.21 | 14 | 295366 | 27817 | 53025869 |
| Sepsis | 105.15 | 14.21 | 435 | 294945 | 145994 | 52907692 |
| Immunodeficiency | 104.58 | 14.21 | 246 | 295134 | 14721 | 53038965 |
| Treatment noncompliance | 104.29 | 14.21 | 27 | 295353 | 33008 | 53020678 |
| Restlessness | 103.16 | 14.21 | 16 | 295364 | 28071 | 53025615 |
| Stevens-Johnson syndrome | 102.69 | 14.21 | 9 | 295371 | 24573 | 53029113 |
| Pneumonia viral | 102.32 | 14.21 | 159 | 295221 | 6953 | 53046733 |
| Abdominal distension | 102.09 | 14.21 | 178 | 295202 | 79612 | 52974074 |
| Human antichimeric antibody positive | 101.80 | 14.21 | 76 | 295304 | 1397 | 53052289 |
| Pulmonary hypertension | 100.77 | 14.21 | 40 | 295340 | 37230 | 53016456 |
| Body temperature increased | 100.73 | 14.21 | 404 | 294976 | 32395 | 53021291 |
| Sinus tachycardia | 100.20 | 14.21 | 8 | 295372 | 23564 | 53030122 |
| Wheezing | 99.61 | 14.21 | 129 | 295251 | 65146 | 52988540 |
| Basal cell carcinoma | 99.30 | 14.21 | 321 | 295059 | 23148 | 53030538 |
| Dyspnoea exertional | 98.93 | 14.21 | 95 | 295285 | 54905 | 52998781 |
| Encephalopathy | 98.71 | 14.21 | 40 | 295340 | 36768 | 53016918 |
| Psoriatic arthropathy | 98.63 | 14.21 | 527 | 294853 | 47663 | 53006023 |
| Pulmonary toxicity | 98.60 | 14.21 | 135 | 295245 | 5256 | 53048430 |
| Urinary retention | 98.44 | 14.21 | 19 | 295361 | 28447 | 53025239 |
| Drug eruption | 97.96 | 14.21 | 334 | 295046 | 24760 | 53028926 |
| Bone density decreased | 96.75 | 14.21 | 199 | 295181 | 10865 | 53042821 |
| Bone pain | 96.73 | 14.21 | 83 | 295297 | 50639 | 53003047 |
| Dysuria | 95.93 | 14.21 | 25 | 295355 | 30428 | 53023258 |
| Drug reaction with eosinophilia and systemic symptoms | 95.84 | 14.21 | 31 | 295349 | 32769 | 53020917 |
| Cough | 95.50 | 14.21 | 935 | 294445 | 255958 | 52797728 |
| Blood sodium decreased | 95.12 | 14.21 | 9 | 295371 | 23107 | 53030579 |
| Bone marrow failure | 94.33 | 14.21 | 25 | 295355 | 30090 | 53023596 |
| Aphasia | 93.70 | 14.21 | 27 | 295353 | 30751 | 53022935 |
| Jaundice | 93.38 | 14.21 | 26 | 295354 | 30287 | 53023399 |
| Chills | 92.91 | 14.21 | 285 | 295095 | 104563 | 52949123 |
| Accidental exposure to product | 92.84 | 14.21 | 11 | 295369 | 23663 | 53030023 |
| Rheumatoid factor negative | 92.42 | 14.21 | 51 | 295329 | 539 | 53053147 |
| Fibromyalgia | 92.25 | 14.21 | 485 | 294895 | 43590 | 53010096 |
| Speech disorder | 92.15 | 14.21 | 51 | 295329 | 39130 | 53014556 |
| Accidental overdose | 92.12 | 14.21 | 7 | 295373 | 21472 | 53032214 |
| Red blood cell sedimentation rate | 91.90 | 14.21 | 97 | 295283 | 2862 | 53050824 |
| Physical disability | 91.46 | 14.21 | 80 | 295300 | 1858 | 53051828 |
| Joint range of motion decreased | 90.38 | 14.21 | 261 | 295119 | 17695 | 53035991 |
| Haemophagocytic lymphohistiocytosis | 90.33 | 14.21 | 173 | 295207 | 8964 | 53044722 |
| Grip strength decreased | 89.71 | 14.21 | 200 | 295180 | 11549 | 53042137 |
| Blood urea increased | 89.68 | 14.21 | 18 | 295362 | 26213 | 53027473 |
| Product prescribing error | 89.59 | 14.21 | 11 | 295369 | 23020 | 53030666 |
| Flushing | 88.06 | 14.21 | 160 | 295220 | 70440 | 52983246 |
| Type 2 diabetes mellitus | 87.77 | 14.21 | 378 | 295002 | 31292 | 53022394 |
| Chronic kidney disease | 87.66 | 14.21 | 67 | 295313 | 43303 | 53010383 |
| Hallucination, visual | 87.24 | 14.21 | 4 | 295376 | 18828 | 53034858 |
| Respiratory distress | 87.13 | 14.21 | 39 | 295341 | 33788 | 53019898 |
| Arrhythmia | 86.31 | 14.21 | 48 | 295332 | 36731 | 53016955 |
| Haematuria | 86.25 | 14.21 | 25 | 295355 | 28364 | 53025322 |
| Blood calcium decreased | 86.18 | 14.21 | 6 | 295374 | 19788 | 53033898 |
| Pulmonary arterial hypertension | 85.94 | 14.21 | 22 | 295358 | 27100 | 53026586 |
| Blood pressure fluctuation | 85.32 | 14.21 | 406 | 294974 | 35064 | 53018622 |
| Hepatic failure | 85.09 | 14.21 | 46 | 295334 | 35760 | 53017926 |
| Altered state of consciousness | 85.00 | 14.21 | 17 | 295363 | 24819 | 53028867 |
| Surgical failure | 84.97 | 14.21 | 57 | 295323 | 877 | 53052809 |
| Dry mouth | 83.55 | 14.21 | 125 | 295255 | 59425 | 52994261 |
| Presyncope | 83.48 | 14.21 | 21 | 295359 | 26173 | 53027513 |
| Pollakiuria | 81.80 | 14.21 | 21 | 295359 | 25818 | 53027868 |
| Exposure during pregnancy | 81.70 | 14.21 | 384 | 294996 | 124476 | 52929210 |
| Onychomycosis | 81.23 | 14.21 | 120 | 295260 | 5016 | 53048670 |
| Circulatory collapse | 81.05 | 14.21 | 14 | 295366 | 22700 | 53030986 |
| Dry skin | 80.04 | 14.21 | 81 | 295299 | 45679 | 53008007 |
| Acute myocardial infarction | 80.00 | 14.21 | 42 | 295338 | 33193 | 53020493 |
| Spinal column injury | 78.78 | 14.21 | 73 | 295307 | 1832 | 53051854 |
| Diabetic ketoacidosis | 78.73 | 14.21 | 9 | 295371 | 19906 | 53033780 |
| Ventricular tachycardia | 78.46 | 14.21 | 5 | 295375 | 17757 | 53035929 |
| Withdrawal syndrome | 78.14 | 14.21 | 8 | 295372 | 19293 | 53034393 |
| Device issue | 78.05 | 14.21 | 13 | 295367 | 21645 | 53032041 |
| Malaise | 77.52 | 14.21 | 1454 | 293926 | 356163 | 52697523 |
| Asthma | 77.41 | 14.21 | 325 | 295055 | 108647 | 52945039 |
| Full blood count decreased | 77.09 | 14.21 | 19 | 295361 | 24010 | 53029676 |
| Mental disorder | 76.80 | 14.21 | 20 | 295360 | 24356 | 53029330 |
| Toothache | 76.67 | 14.21 | 246 | 295134 | 17668 | 53036018 |
| Rectal haemorrhage | 76.54 | 14.21 | 70 | 295310 | 41411 | 53012275 |
| Renal disorder | 75.99 | 14.21 | 33 | 295347 | 29106 | 53024580 |
| Ejection fraction decreased | 75.94 | 14.21 | 10 | 295370 | 19838 | 53033848 |
| Cardiomegaly | 75.78 | 14.21 | 6 | 295374 | 17794 | 53035892 |
| White blood cell count decreased | 75.59 | 14.21 | 393 | 294987 | 124082 | 52929604 |
| Blood creatine phosphokinase increased | 75.32 | 14.21 | 33 | 295347 | 28952 | 53024734 |
| Angioedema | 75.30 | 14.21 | 73 | 295307 | 42003 | 53011683 |
| Haematochezia | 75.21 | 14.21 | 74 | 295306 | 42284 | 53011402 |
| Blood creatinine increased | 75.16 | 14.21 | 222 | 295158 | 82440 | 52971246 |
| Hemiparesis | 74.97 | 14.21 | 14 | 295366 | 21461 | 53032225 |
| Myocardial infarction | 73.91 | 14.21 | 291 | 295089 | 99063 | 52954623 |
| Haematocrit decreased | 73.76 | 14.21 | 59 | 295321 | 37272 | 53016414 |
| Haemorrhage | 73.59 | 14.21 | 130 | 295250 | 57857 | 52995829 |
| Electrolyte imbalance | 73.50 | 14.21 | 9 | 295371 | 18875 | 53034811 |
| Abortion spontaneous | 73.40 | 14.21 | 90 | 295290 | 46545 | 53007141 |
| Ulcer | 73.20 | 14.21 | 266 | 295114 | 20353 | 53033333 |
| Red cell distribution width decreased | 73.01 | 14.21 | 54 | 295326 | 978 | 53052708 |
| Thrombosis | 72.97 | 14.21 | 141 | 295239 | 60652 | 52993034 |
| Pericardial effusion | 72.57 | 14.21 | 30 | 295350 | 27248 | 53026438 |
| Cholestasis | 72.48 | 14.21 | 34 | 295346 | 28661 | 53025025 |
| Unevaluable event | 72.29 | 14.21 | 101 | 295279 | 49397 | 53004289 |
| Vaginal haemorrhage | 72.25 | 14.21 | 29 | 295351 | 26812 | 53026874 |
| Colitis microscopic | 72.21 | 14.21 | 136 | 295244 | 6958 | 53046728 |
| Food allergy | 72.08 | 14.21 | 148 | 295232 | 8070 | 53045616 |
| Gamma-glutamyltransferase increased | 71.51 | 14.21 | 49 | 295331 | 33506 | 53020180 |
| Melaena | 71.32 | 14.21 | 36 | 295344 | 29093 | 53024593 |
| Obstructive airways disorder | 71.15 | 14.21 | 7 | 295373 | 17422 | 53036264 |
| Impaired work ability | 71.10 | 14.21 | 205 | 295175 | 13885 | 53039801 |
| Metastases to bone | 71.00 | 14.21 | 11 | 295369 | 19317 | 53034369 |
| Vascular access complication | 70.43 | 14.21 | 55 | 295325 | 1084 | 53052602 |
| Therapeutic response unexpected | 70.33 | 14.21 | 7 | 295373 | 17263 | 53036423 |
| Nightmare | 70.23 | 14.21 | 8 | 295372 | 17743 | 53035943 |
| Joint injury | 70.09 | 14.21 | 275 | 295105 | 21825 | 53031861 |
| Atelectasis | 69.54 | 14.21 | 13 | 295367 | 19913 | 53033773 |
| Mean platelet volume decreased | 69.33 | 14.21 | 64 | 295316 | 1598 | 53052088 |
| Tubulointerstitial nephritis | 69.05 | 14.21 | 6 | 295374 | 16498 | 53037188 |
| Acute respiratory failure | 68.84 | 14.21 | 44 | 295336 | 31214 | 53022472 |
| Haematemesis | 68.55 | 14.21 | 43 | 295337 | 30814 | 53022872 |
| Nervousness | 68.51 | 14.21 | 41 | 295339 | 30137 | 53023549 |
| Herpes zoster | 68.30 | 14.21 | 668 | 294712 | 73351 | 52980335 |
| Hypersomnia | 68.28 | 14.21 | 6 | 295374 | 16349 | 53037337 |
| Blood pressure diastolic increased | 68.12 | 14.21 | 133 | 295247 | 6991 | 53046695 |
| Rash macular | 67.83 | 14.21 | 16 | 295364 | 20831 | 53032855 |
| Device dislocation | 67.72 | 14.21 | 23 | 295357 | 23574 | 53030112 |
| Oral herpes | 67.54 | 14.21 | 264 | 295116 | 20915 | 53032771 |
| Transient ischaemic attack | 67.46 | 14.21 | 59 | 295321 | 35666 | 53018020 |
| Multiple sclerosis | 67.32 | 14.21 | 33 | 295347 | 27120 | 53026566 |
| Blood count abnormal | 67.27 | 14.21 | 15 | 295365 | 20300 | 53033386 |
| Arthrodesis | 67.17 | 14.21 | 75 | 295305 | 2361 | 53051325 |
| Blood lactate dehydrogenase increased | 66.50 | 14.21 | 19 | 295361 | 21762 | 53031924 |
| Cardiac disorder | 66.45 | 14.21 | 98 | 295282 | 46868 | 53006818 |
| Heart rate decreased | 66.27 | 14.21 | 390 | 294990 | 36557 | 53017129 |
| Rheumatoid lung | 66.25 | 14.21 | 73 | 295307 | 2264 | 53051422 |
| Loose body in joint | 66.03 | 14.21 | 54 | 295326 | 1140 | 53052546 |
| Musculoskeletal disorder | 65.76 | 14.21 | 230 | 295150 | 17269 | 53036417 |
| Staphylococcal infection | 65.43 | 14.21 | 70 | 295310 | 38478 | 53015208 |
| Migraine | 65.40 | 14.21 | 227 | 295153 | 80190 | 52973496 |
| Cerebral haemorrhage | 65.00 | 14.21 | 43 | 295337 | 29953 | 53023733 |
| Visual acuity reduced | 64.38 | 14.21 | 22 | 295358 | 22463 | 53031223 |
| Demyelination | 64.15 | 14.21 | 120 | 295260 | 6107 | 53047579 |
| Blood glucose decreased | 63.87 | 14.21 | 16 | 295364 | 20000 | 53033686 |
| Product administration error | 63.53 | 14.21 | 20 | 295360 | 21511 | 53032175 |
| Colitis | 63.51 | 14.21 | 82 | 295298 | 41470 | 53012216 |
| Antibody test positive | 63.09 | 14.21 | 71 | 295309 | 2255 | 53051431 |
| Epilepsy | 62.85 | 14.21 | 32 | 295348 | 25735 | 53027951 |
| Bedridden | 62.64 | 14.21 | 156 | 295224 | 9681 | 53044005 |
| Injection site pruritus | 62.61 | 14.21 | 83 | 295297 | 41506 | 53012180 |
| Cutaneous vasculitis | 62.49 | 14.21 | 99 | 295281 | 4402 | 53049284 |
| Vertigo | 62.28 | 14.21 | 136 | 295244 | 55945 | 52997741 |
| Premature delivery | 61.35 | 14.21 | 34 | 295346 | 26070 | 53027616 |
| Injection site swelling | 61.24 | 14.21 | 88 | 295292 | 42540 | 53011146 |
| Pharyngitis | 60.86 | 14.21 | 237 | 295143 | 18743 | 53034943 |
| Clostridium difficile colitis | 60.79 | 14.21 | 17 | 295363 | 19748 | 53033938 |
| Pancreatitis | 60.79 | 14.21 | 101 | 295279 | 46041 | 53007645 |
| Respiratory disorder | 60.57 | 14.21 | 359 | 295021 | 33738 | 53019948 |
| Lip swelling | 60.30 | 14.21 | 38 | 295342 | 27163 | 53026523 |
| Small intestinal obstruction | 60.24 | 14.21 | 11 | 295369 | 17136 | 53036550 |
| Eating disorder | 60.00 | 14.21 | 9 | 295371 | 16188 | 53037498 |
| Ataxia | 59.95 | 14.21 | 6 | 295374 | 14731 | 53038955 |
| Retinal toxicity | 59.70 | 14.21 | 51 | 295329 | 1146 | 53052540 |
| Hyperhidrosis | 59.66 | 14.21 | 304 | 295076 | 96489 | 52957197 |
| Infusion site reaction | 58.95 | 14.21 | 66 | 295314 | 2084 | 53051602 |
| Red blood cell count decreased | 58.95 | 14.21 | 67 | 295313 | 35836 | 53017850 |
| Muscle twitching | 58.88 | 14.21 | 10 | 295370 | 16416 | 53037270 |
| Intestinal obstruction | 58.59 | 14.21 | 44 | 295336 | 28697 | 53024989 |
| Osteoporotic fracture | 58.45 | 14.21 | 81 | 295299 | 3190 | 53050496 |
| Lymphocyte count decreased | 58.41 | 14.21 | 42 | 295338 | 28010 | 53025676 |
| Tricuspid valve incompetence | 58.20 | 14.21 | 6 | 295374 | 14390 | 53039296 |
| Urinary incontinence | 58.08 | 14.21 | 51 | 295329 | 30770 | 53022916 |
| Mitral valve incompetence | 57.97 | 14.21 | 18 | 295362 | 19533 | 53034153 |
| Upper gastrointestinal haemorrhage | 57.46 | 14.21 | 13 | 295367 | 17417 | 53036269 |
| Neutropenic sepsis | 56.97 | 14.21 | 7 | 295373 | 14642 | 53039044 |
| Hypothermia | 56.72 | 14.21 | 4 | 295376 | 13052 | 53040634 |
| Feeling hot | 56.55 | 14.21 | 89 | 295291 | 41455 | 53012231 |
| Eye swelling | 55.89 | 14.21 | 25 | 295355 | 21669 | 53032017 |
| Fear | 55.69 | 14.21 | 12 | 295368 | 16629 | 53037057 |
| Influenza like illness | 55.64 | 14.21 | 163 | 295217 | 60696 | 52992990 |
| Myelosuppression | 55.53 | 14.21 | 4 | 295376 | 12824 | 53040862 |
| Multiple organ dysfunction syndrome | 55.47 | 14.21 | 143 | 295237 | 55534 | 52998152 |
| Diplopia | 54.97 | 14.21 | 23 | 295357 | 20742 | 53032944 |
| Anal incontinence | 54.58 | 14.21 | 4 | 295376 | 12643 | 53041043 |
| Haemoptysis | 54.54 | 14.21 | 45 | 295335 | 27994 | 53025692 |
| Sinus bradycardia | 54.35 | 14.21 | 8 | 295372 | 14593 | 53039093 |
| Limb mass | 54.30 | 14.21 | 73 | 295307 | 2792 | 53050894 |
| Finger deformity | 54.30 | 14.21 | 106 | 295274 | 5571 | 53048115 |
| Premature baby | 53.94 | 14.21 | 21 | 295359 | 19780 | 53033906 |
| Dystonia | 53.76 | 14.21 | 5 | 295375 | 13016 | 53040670 |
| Infusion site pain | 53.27 | 14.21 | 3 | 295377 | 11830 | 53041856 |
| Oedema | 53.24 | 14.21 | 221 | 295159 | 74125 | 52979561 |
| Clostridium difficile infection | 52.74 | 14.21 | 46 | 295334 | 27847 | 53025839 |
| Diverticular perforation | 52.70 | 14.21 | 79 | 295301 | 3346 | 53050340 |
| Confusional state | 52.44 | 14.21 | 758 | 294622 | 193463 | 52860223 |
| Acute hepatic failure | 52.14 | 14.21 | 14 | 295366 | 16706 | 53036980 |
| Neutrophil count decreased | 52.13 | 14.21 | 122 | 295258 | 48976 | 53004710 |
| Disability | 52.02 | 14.21 | 170 | 295210 | 12328 | 53041358 |
| Joint arthroplasty | 51.90 | 14.21 | 62 | 295318 | 2102 | 53051584 |
| Myelodysplastic syndrome | 51.86 | 14.21 | 14 | 295366 | 16646 | 53037040 |
| Gastritis | 51.85 | 14.21 | 75 | 295305 | 36159 | 53017527 |
| Presbyacusis | 51.84 | 14.21 | 73 | 295307 | 2919 | 53050767 |
| Blood albumin decreased | 51.80 | 14.21 | 9 | 295371 | 14533 | 53039153 |
| Fine motor skill dysfunction | 51.68 | 14.21 | 87 | 295293 | 4072 | 53049614 |
| Bursitis | 51.60 | 14.21 | 254 | 295126 | 22238 | 53031448 |
| Hypocalcaemia | 51.22 | 14.21 | 52 | 295328 | 29285 | 53024401 |
| Renal tubular necrosis | 51.09 | 14.21 | 3 | 295377 | 11416 | 53042270 |
| Soft tissue disorder | 51.01 | 14.21 | 88 | 295292 | 4202 | 53049484 |
| Night sweats | 50.98 | 14.21 | 350 | 295030 | 34597 | 53019089 |
| Mood altered | 50.86 | 14.21 | 8 | 295372 | 13893 | 53039793 |
| Anuria | 50.77 | 14.21 | 5 | 295375 | 12435 | 53041251 |
| X-ray abnormal | 50.63 | 14.21 | 64 | 295316 | 2302 | 53051384 |
| Nodule | 50.59 | 14.21 | 211 | 295169 | 17218 | 53036468 |
| Transaminases abnormal | 50.53 | 14.21 | 35 | 295345 | 569 | 53053117 |
| Flatulence | 50.47 | 14.21 | 60 | 295320 | 31457 | 53022229 |
| Dementia | 50.42 | 14.21 | 15 | 295365 | 16735 | 53036951 |
| Oesophagitis | 50.32 | 14.21 | 10 | 295370 | 14667 | 53039019 |
| Device malfunction | 50.22 | 14.21 | 13 | 295367 | 15895 | 53037791 |
| Osteonecrosis | 50.04 | 14.21 | 44 | 295336 | 26531 | 53027155 |
| Tachypnoea | 49.96 | 14.21 | 13 | 295367 | 15841 | 53037845 |
| Cyanosis | 49.91 | 14.21 | 15 | 295365 | 16624 | 53037062 |
| Injection site mass | 49.77 | 14.21 | 14 | 295366 | 16200 | 53037486 |
| Faeces discoloured | 49.45 | 14.21 | 18 | 295362 | 17668 | 53036018 |
| Ageusia | 49.12 | 14.21 | 6 | 295374 | 12608 | 53041078 |
| Polyarthritis | 49.05 | 14.21 | 123 | 295257 | 7666 | 53046020 |
| Frequent bowel movements | 49.04 | 14.21 | 10 | 295370 | 14402 | 53039284 |
| Sinus disorder | 48.84 | 14.21 | 21 | 295359 | 18633 | 53035053 |
| Gastrointestinal perforation | 48.57 | 14.21 | 76 | 295304 | 3343 | 53050343 |
| Cardiogenic shock | 48.52 | 14.21 | 18 | 295362 | 17464 | 53036222 |
| Peptic ulcer haemorrhage | 48.26 | 14.21 | 43 | 295337 | 1024 | 53052662 |
| Pallor | 48.26 | 14.21 | 41 | 295339 | 25141 | 53028545 |
| Hyperlipidaemia | 47.95 | 14.21 | 24 | 295356 | 19491 | 53034195 |
| Mean cell volume decreased | 47.75 | 14.21 | 67 | 295313 | 2670 | 53051016 |
| Blood magnesium decreased | 47.56 | 14.21 | 5 | 295375 | 11809 | 53041877 |
| Pleural thickening | 47.50 | 14.21 | 66 | 295314 | 2606 | 53051080 |
| Right ventricular failure | 47.33 | 14.21 | 17 | 295363 | 16826 | 53036860 |
| Metastases to liver | 46.33 | 14.21 | 31 | 295349 | 21465 | 53032221 |
| Swelling face | 46.06 | 14.21 | 162 | 295218 | 57006 | 52996680 |
| Acute myeloid leukaemia | 46.05 | 14.21 | 18 | 295362 | 16914 | 53036772 |
| Malignant melanoma | 45.92 | 14.21 | 148 | 295232 | 10654 | 53043032 |
| Neurotoxicity | 45.74 | 14.21 | 14 | 295366 | 15335 | 53038351 |
| Injection site warmth | 45.65 | 14.21 | 11 | 295369 | 14117 | 53039569 |
| Breast cancer metastatic | 45.65 | 14.21 | 14 | 295366 | 15314 | 53038372 |
| Abortion induced | 45.12 | 14.21 | 4 | 295376 | 10822 | 53042864 |
| Schizophrenia | 45.09 | 14.21 | 3 | 295377 | 10276 | 53043410 |
| Aspiration | 44.73 | 14.21 | 3 | 295377 | 10207 | 53043479 |
| Retching | 44.73 | 14.21 | 11 | 295369 | 13922 | 53039764 |
| Localised infection | 44.72 | 14.21 | 277 | 295103 | 26439 | 53027247 |
| Joint effusion | 44.68 | 14.21 | 169 | 295211 | 13183 | 53040503 |
| Pleural fibrosis | 44.20 | 14.21 | 75 | 295305 | 3533 | 53050153 |
| Body temperature decreased | 44.19 | 14.21 | 196 | 295184 | 16431 | 53037255 |
| Drug specific antibody | 44.00 | 14.21 | 49 | 295331 | 1538 | 53052148 |
| Agranulocytosis | 43.90 | 14.21 | 40 | 295340 | 23709 | 53029977 |
| Face oedema | 43.87 | 14.21 | 29 | 295351 | 20211 | 53033475 |
| Interstitial lung disease | 43.75 | 14.21 | 507 | 294873 | 58115 | 52995571 |
| Delusion | 43.74 | 14.21 | 7 | 295373 | 12002 | 53041684 |
| Multiple fractures | 43.64 | 14.21 | 106 | 295274 | 6475 | 53047211 |
| Ventricular fibrillation | 43.32 | 14.21 | 7 | 295373 | 11918 | 53041768 |
| Premature labour | 43.28 | 14.21 | 8 | 295372 | 12354 | 53041332 |
| Systemic lupus erythematosus rash | 43.28 | 14.21 | 50 | 295330 | 1635 | 53052051 |
| Ankle arthroplasty | 43.25 | 14.21 | 37 | 295343 | 833 | 53052853 |
| Hypercholesterolaemia | 43.23 | 14.21 | 161 | 295219 | 12465 | 53041221 |
| Status epilepticus | 43.22 | 14.21 | 15 | 295365 | 15169 | 53038517 |
| Renal injury | 43.12 | 14.21 | 3 | 295377 | 9901 | 53043785 |
| Eosinophilia | 43.06 | 14.21 | 33 | 295347 | 21302 | 53032384 |
| Leukocytosis | 43.00 | 14.21 | 44 | 295336 | 24690 | 53028996 |
| Coagulopathy | 43.00 | 14.21 | 28 | 295352 | 19670 | 53034016 |
| Brain oedema | 42.95 | 14.21 | 11 | 295369 | 13547 | 53040139 |
| Hypovolaemia | 42.93 | 14.21 | 4 | 295376 | 10398 | 53043288 |
| Prothrombin time prolonged | 42.69 | 14.21 | 3 | 295377 | 9819 | 53043867 |
| Glaucoma | 42.63 | 14.21 | 197 | 295183 | 16806 | 53036880 |
| Dermatitis allergic | 42.35 | 14.21 | 168 | 295212 | 13400 | 53040286 |
| Nail disorder | 42.28 | 14.21 | 135 | 295245 | 9670 | 53044016 |
| Growth failure | 42.23 | 14.21 | 25 | 295355 | 305 | 53053381 |
| Progressive multifocal leukoencephalopathy | 42.14 | 14.21 | 8 | 295372 | 12121 | 53041565 |
| Cardiomyopathy | 42.01 | 14.21 | 21 | 295359 | 17067 | 53036619 |
| Haematoma | 41.93 | 14.21 | 77 | 295303 | 33767 | 53019919 |
| Urine output decreased | 41.83 | 14.21 | 7 | 295373 | 11616 | 53042070 |
| Myocardial ischaemia | 41.50 | 14.21 | 10 | 295370 | 12834 | 53040852 |
| Wheelchair user | 41.25 | 14.21 | 86 | 295294 | 4740 | 53048946 |
| Cholecystitis chronic | 40.97 | 14.21 | 5 | 295375 | 10513 | 53043173 |
| Mean cell haemoglobin decreased | 40.81 | 14.21 | 70 | 295310 | 3327 | 53050359 |
| Hepatitis | 40.63 | 14.21 | 324 | 295056 | 33570 | 53020116 |
| Arthritis bacterial | 40.52 | 14.21 | 98 | 295282 | 5970 | 53047716 |
| Subdural haematoma | 40.45 | 14.21 | 13 | 295367 | 13800 | 53039886 |
| Hypokinesia | 40.45 | 14.21 | 11 | 295369 | 13016 | 53040670 |
| Shock | 40.41 | 14.21 | 41 | 295339 | 23098 | 53030588 |
| Exostosis | 40.23 | 14.21 | 147 | 295233 | 11277 | 53042409 |
| Sleep apnoea syndrome | 40.06 | 14.21 | 51 | 295329 | 25951 | 53027735 |
| Iron deficiency anaemia | 39.77 | 14.21 | 27 | 295353 | 18553 | 53035133 |
| Acute generalised exanthematous pustulosis | 39.77 | 14.21 | 5 | 295375 | 10276 | 53043410 |
| Escherichia infection | 39.69 | 14.21 | 9 | 295371 | 12041 | 53041645 |
| Vasculitic rash | 39.66 | 14.21 | 43 | 295337 | 1309 | 53052377 |
| Pancreatitis acute | 39.41 | 14.21 | 52 | 295328 | 26057 | 53027629 |
| Lung infiltration | 39.40 | 14.21 | 16 | 295364 | 14691 | 53038995 |
| Supraventricular tachycardia | 39.34 | 14.21 | 15 | 295365 | 14310 | 53039376 |
| Weight decreased | 39.05 | 14.21 | 996 | 294384 | 233952 | 52819734 |
| Eczema | 38.76 | 14.21 | 46 | 295334 | 24136 | 53029550 |
| White blood cell count abnormal | 38.45 | 14.21 | 89 | 295291 | 5269 | 53048417 |
| Pulmonary mass | 38.39 | 14.21 | 215 | 295165 | 19789 | 53033897 |
| Hepatocellular injury | 38.24 | 14.21 | 67 | 295313 | 29919 | 53023767 |
| Complication associated with device | 38.07 | 14.21 | 21 | 295359 | 16144 | 53037542 |
| Cold sweat | 37.84 | 14.21 | 9 | 295371 | 11653 | 53042033 |
| Left ventricular dysfunction | 37.81 | 14.21 | 8 | 295372 | 11229 | 53042457 |
| Intercepted product storage error | 37.71 | 14.21 | 12 | 295368 | 23 | 53053663 |
| Glomerular filtration rate decreased | 37.41 | 14.21 | 12 | 295368 | 12755 | 53040931 |
| Toxic skin eruption | 37.37 | 14.21 | 13 | 295367 | 13126 | 53040560 |
| Infiltration anaesthesia | 37.20 | 14.21 | 18 | 295362 | 141 | 53053545 |
| Concomitant disease aggravated | 37.04 | 14.21 | 3 | 295377 | 8735 | 53044951 |
| Oliguria | 36.96 | 14.21 | 4 | 295376 | 9234 | 53044452 |
| Incorrect product administration duration | 36.93 | 14.21 | 7 | 295373 | 10617 | 53043069 |
| Pruritus allergic | 36.92 | 14.21 | 38 | 295342 | 1088 | 53052598 |
| Paranoia | 36.71 | 14.21 | 9 | 295371 | 11415 | 53042271 |
| Oral candidiasis | 36.67 | 14.21 | 30 | 295350 | 18743 | 53034943 |
| Blood magnesium increased | 36.28 | 14.21 | 63 | 295317 | 3024 | 53050662 |
| Viral upper respiratory tract infection | 35.99 | 14.21 | 105 | 295275 | 7159 | 53046527 |
| Head injury | 35.48 | 14.21 | 55 | 295325 | 25778 | 53027908 |
| Hypotonia | 35.44 | 14.21 | 4 | 295376 | 8937 | 53044749 |
| Renal impairment | 35.37 | 14.21 | 293 | 295087 | 83025 | 52970661 |
| Mesenteritis | 35.05 | 14.21 | 17 | 295363 | 134 | 53053552 |
| Aplastic anaemia | 34.88 | 14.21 | 3 | 295377 | 8318 | 53045368 |
| Device related infection | 34.78 | 14.21 | 45 | 295335 | 22741 | 53030945 |
| Adverse event | 34.71 | 14.21 | 364 | 295016 | 40697 | 53012989 |
| Blood calcium increased | 34.44 | 14.21 | 3 | 295377 | 8233 | 53045453 |
| Ileus | 34.39 | 14.21 | 20 | 295360 | 14935 | 53038751 |
| Ventricular extrasystoles | 34.39 | 14.21 | 11 | 295369 | 11713 | 53041973 |
| Malnutrition | 34.04 | 14.21 | 20 | 295360 | 14851 | 53038835 |
| Atrial flutter | 34.02 | 14.21 | 6 | 295374 | 9585 | 53044101 |
| Anger | 33.98 | 14.21 | 13 | 295367 | 12377 | 53041309 |
| Psoriasis | 33.98 | 14.21 | 313 | 295067 | 86776 | 52966910 |
| Torus fracture | 33.88 | 14.21 | 16 | 295364 | 118 | 53053568 |
| Extremity contracture | 33.79 | 14.21 | 39 | 295341 | 1274 | 53052412 |
| Nonalcoholic fatty liver disease | 33.79 | 14.21 | 35 | 295345 | 1010 | 53052676 |
| Peritonitis bacterial | 33.60 | 14.21 | 6 | 295374 | 9499 | 53044187 |
| Device difficult to use | 33.60 | 14.21 | 8 | 295372 | 10351 | 53043335 |
| Hysterectomy | 33.51 | 14.21 | 4 | 295376 | 8557 | 53045129 |
| Femur fracture | 33.50 | 14.21 | 351 | 295029 | 39234 | 53014452 |
| Injection site urticaria | 33.32 | 14.21 | 14 | 295366 | 12593 | 53041093 |
| Joint dislocation | 33.17 | 14.21 | 146 | 295234 | 12199 | 53041487 |
| Hypoaesthesia | 33.14 | 14.21 | 527 | 294853 | 132468 | 52921218 |
| Skin papilloma | 33.12 | 14.21 | 75 | 295305 | 4376 | 53049310 |
| Sensory loss | 32.73 | 14.21 | 3 | 295377 | 7902 | 53045784 |
| Device breakage | 32.66 | 14.21 | 9 | 295371 | 10558 | 53043128 |
| Feeling jittery | 32.61 | 14.21 | 13 | 295367 | 12070 | 53041616 |
| Posterior reversible encephalopathy syndrome | 32.60 | 14.21 | 25 | 295355 | 16135 | 53037551 |
| Blood pressure abnormal | 32.50 | 14.21 | 17 | 295363 | 13466 | 53040220 |
| Infusion site erythema | 32.45 | 14.21 | 5 | 295375 | 8817 | 53044869 |
| Ischaemic stroke | 32.44 | 14.21 | 31 | 295349 | 17962 | 53035724 |
| Myopathy | 32.41 | 14.21 | 7 | 295373 | 9685 | 53044001 |
| Ocular hyperaemia | 32.28 | 14.21 | 44 | 295336 | 21747 | 53031939 |
| Macular degeneration | 32.23 | 14.21 | 14 | 295366 | 12347 | 53041339 |
| Haemolytic anaemia | 32.07 | 14.21 | 9 | 295371 | 10430 | 53043256 |
| Panic attack | 31.98 | 14.21 | 43 | 295337 | 21375 | 53032311 |
| Contusion | 31.90 | 14.21 | 821 | 294559 | 109911 | 52943775 |
| Pelvic pain | 31.84 | 14.21 | 14 | 295366 | 12259 | 53041427 |
| Flank pain | 31.79 | 14.21 | 19 | 295361 | 13977 | 53039709 |
| Deafness neurosensory | 31.72 | 14.21 | 77 | 295303 | 4701 | 53048985 |
| Hypercalcaemia | 31.54 | 14.21 | 237 | 295143 | 24111 | 53029575 |
| Injection site hypersensitivity | 31.09 | 14.21 | 43 | 295337 | 1690 | 53051996 |
| Paralysis | 30.93 | 14.21 | 7 | 295373 | 9377 | 53044309 |
| Central nervous system lesion | 30.77 | 14.21 | 9 | 295371 | 10153 | 53043533 |
| Deafness | 30.50 | 14.21 | 30 | 295350 | 17146 | 53036540 |
| Onychomadesis | 30.13 | 14.21 | 64 | 295316 | 3574 | 53050112 |
| Anti-cyclic citrullinated peptide antibody | 30.13 | 14.21 | 32 | 295348 | 951 | 53052735 |
| Hypoaesthesia oral | 30.09 | 14.21 | 13 | 295367 | 11503 | 53042183 |
| Autoimmune hepatitis | 29.96 | 14.21 | 5 | 295375 | 8313 | 53045373 |
| Apathy | 29.93 | 14.21 | 5 | 295375 | 8307 | 53045379 |
| Haemorrhoids | 29.72 | 14.21 | 42 | 295338 | 20447 | 53033239 |
| Hemiplegia | 29.67 | 14.21 | 4 | 295376 | 7796 | 53045890 |
| Skin discolouration | 29.51 | 14.21 | 98 | 295282 | 35094 | 53018592 |
| Adverse drug reaction | 29.24 | 14.21 | 438 | 294942 | 53187 | 53000499 |
| Intestinal sepsis | 29.10 | 14.21 | 18 | 295362 | 239 | 53053447 |
| Nephropathy toxic | 29.06 | 14.21 | 6 | 295374 | 8566 | 53045120 |
| Peripheral sensory neuropathy | 28.84 | 14.21 | 3 | 295377 | 7145 | 53046541 |
| Rash papular | 28.80 | 14.21 | 20 | 295360 | 13582 | 53040104 |
| Arteriosclerosis | 28.76 | 14.21 | 10 | 295370 | 10101 | 53043585 |
| Hip fracture | 28.59 | 14.21 | 72 | 295308 | 28185 | 53025501 |
| Major depression | 28.58 | 14.21 | 4 | 295376 | 7578 | 53046108 |
| Chromaturia | 28.16 | 14.21 | 28 | 295352 | 15922 | 53037764 |
| Bundle branch block left | 28.15 | 14.21 | 3 | 295377 | 7010 | 53046676 |
| Loss of consciousness | 27.98 | 14.21 | 454 | 294926 | 113758 | 52939928 |
| Polyuria | 27.95 | 14.21 | 5 | 295375 | 7906 | 53045780 |
| Heavy menstrual bleeding | 27.90 | 14.21 | 33 | 295347 | 17343 | 53036343 |
| Therapy non-responder | 27.87 | 14.21 | 404 | 294976 | 48716 | 53004970 |
| Tumour lysis syndrome | 27.77 | 14.21 | 5 | 295375 | 7869 | 53045817 |
| Pulmonary haemorrhage | 27.74 | 14.21 | 3 | 295377 | 6930 | 53046756 |
| Eructation | 27.68 | 14.21 | 5 | 295375 | 7850 | 53045836 |
| Glycosylated haemoglobin increased | 27.65 | 14.21 | 15 | 295365 | 11640 | 53042046 |
| Liver disorder | 27.64 | 14.21 | 342 | 295038 | 39813 | 53013873 |
| Cardiac failure acute | 27.63 | 14.21 | 8 | 295372 | 9084 | 53044602 |
| Hypoalbuminaemia | 27.55 | 14.21 | 13 | 295367 | 10923 | 53042763 |
| Accident | 27.54 | 14.21 | 80 | 295300 | 5441 | 53048245 |
| Underdose | 27.53 | 14.21 | 48 | 295332 | 21474 | 53032212 |
| Hypoacusis | 27.47 | 14.21 | 52 | 295328 | 22547 | 53031139 |
| Pre-eclampsia | 27.42 | 14.21 | 7 | 295373 | 8640 | 53045046 |
| Intestinal perforation | 27.17 | 14.21 | 130 | 295250 | 11250 | 53042436 |
| Productive cough | 27.13 | 14.21 | 193 | 295187 | 56536 | 52997150 |
| Rales | 27.10 | 14.21 | 13 | 295367 | 10819 | 53042867 |
| Foetal death | 27.01 | 14.21 | 9 | 295371 | 9338 | 53044348 |
| Drug resistance | 26.94 | 14.21 | 43 | 295337 | 19919 | 53033767 |
| Drug level decreased | 26.93 | 14.21 | 3 | 295377 | 6771 | 53046915 |
| Hot flush | 26.89 | 14.21 | 152 | 295228 | 47008 | 53006678 |
| Device occlusion | 26.88 | 14.21 | 3 | 295377 | 6762 | 53046924 |
| Bipolar disorder | 26.85 | 14.21 | 5 | 295375 | 7681 | 53046005 |
| Crohn's disease | 26.81 | 14.21 | 3 | 295377 | 6747 | 53046939 |
| Gallbladder disorder | 26.58 | 14.21 | 37 | 295343 | 18128 | 53035558 |
| Amyotrophic lateral sclerosis | 26.58 | 14.21 | 32 | 295348 | 1094 | 53052592 |
| Prosthesis user | 26.30 | 14.21 | 12 | 295368 | 81 | 53053605 |
| Graft versus host disease | 26.28 | 14.21 | 4 | 295376 | 7118 | 53046568 |
| Mood swings | 26.21 | 14.21 | 35 | 295345 | 17451 | 53036235 |
| Skin burning sensation | 26.04 | 14.21 | 16 | 295364 | 11594 | 53042092 |
| Injection site reaction | 26.01 | 14.21 | 413 | 294967 | 50753 | 53002933 |
| Eyelid oedema | 25.90 | 14.21 | 13 | 295367 | 10541 | 53043145 |
| Motor dysfunction | 25.87 | 14.21 | 7 | 295373 | 8311 | 53045375 |
| Troponin increased | 25.83 | 14.21 | 8 | 295372 | 8697 | 53044989 |
| Intermenstrual bleeding | 25.80 | 14.21 | 8 | 295372 | 8690 | 53044996 |
| Hepatic encephalopathy | 25.72 | 14.21 | 14 | 295366 | 10845 | 53042841 |
| Ankylosing spondylitis | 25.68 | 14.21 | 101 | 295279 | 8024 | 53045662 |
| Brachiocephalic artery stenosis | 25.49 | 14.21 | 9 | 295371 | 27 | 53053659 |
| Toe amputation | 25.46 | 14.21 | 43 | 295337 | 2018 | 53051668 |
| Bone cyst | 25.37 | 14.21 | 44 | 295336 | 2110 | 53051576 |
| Thrombotic microangiopathy | 25.27 | 14.21 | 10 | 295370 | 9327 | 53044359 |
| Pain of skin | 25.13 | 14.21 | 8 | 295372 | 8544 | 53045142 |
| Erythema | 25.11 | 14.21 | 669 | 294711 | 156300 | 52897386 |
| Electrocardiogram abnormal | 25.10 | 14.21 | 7 | 295373 | 8146 | 53045540 |
| Injection site rash | 25.04 | 14.21 | 33 | 295347 | 16546 | 53037140 |
| Cholelithiasis | 25.03 | 14.21 | 129 | 295251 | 40835 | 53012851 |
| Feeding disorder | 24.97 | 14.21 | 16 | 295364 | 11338 | 53042348 |
| Dysstasia | 24.97 | 14.21 | 42 | 295338 | 19057 | 53034629 |
| Abdominal pain lower | 24.74 | 14.21 | 59 | 295321 | 23534 | 53030152 |
| Vitamin D deficiency | 24.64 | 14.21 | 19 | 295361 | 12229 | 53041457 |
| Cytomegalovirus infection | 24.61 | 14.21 | 44 | 295336 | 19495 | 53034191 |
| Lymphadenopathy | 24.58 | 14.21 | 110 | 295270 | 36145 | 53017541 |
| Wrist surgery | 24.56 | 14.21 | 27 | 295353 | 835 | 53052851 |
| Thirst | 24.50 | 14.21 | 17 | 295363 | 11549 | 53042137 |
| Taste disorder | 24.23 | 14.21 | 7 | 295373 | 7961 | 53045725 |
| Tinnitus | 24.23 | 14.21 | 87 | 295293 | 30432 | 53023254 |
| Rash maculo-papular | 24.16 | 14.21 | 84 | 295296 | 29665 | 53024021 |
| Paraesthesia oral | 24.00 | 14.21 | 22 | 295358 | 13003 | 53040683 |
| Diabetic eye disease | 23.99 | 14.21 | 14 | 295366 | 166 | 53053520 |
| Activated partial thromboplastin time prolonged | 23.80 | 14.21 | 5 | 295375 | 7054 | 53046632 |
| Acute pulmonary oedema | 23.77 | 14.21 | 8 | 295372 | 8247 | 53045439 |
| Metastases to lung | 23.75 | 14.21 | 18 | 295362 | 11686 | 53042000 |
| Genital haemorrhage | 23.73 | 14.21 | 5 | 295375 | 7039 | 53046647 |
| Skin reaction | 23.73 | 14.21 | 131 | 295249 | 11992 | 53041694 |
| Congestive cardiomyopathy | 23.70 | 14.21 | 3 | 295377 | 6135 | 53047551 |
| Metastases to lymph nodes | 23.64 | 14.21 | 6 | 295374 | 7434 | 53046252 |
| Erythema multiforme | 23.57 | 14.21 | 14 | 295366 | 10335 | 53043351 |
| Dermatitis contact | 23.56 | 14.21 | 10 | 295370 | 8942 | 53044744 |
| Orthopnoea | 23.53 | 14.21 | 3 | 295377 | 6101 | 53047585 |
| Illness | 23.49 | 14.21 | 56 | 295324 | 22340 | 53031346 |
| Hyperthermia | 23.49 | 14.21 | 9 | 295371 | 8560 | 53045126 |
| Eye pain | 23.47 | 14.21 | 89 | 295291 | 30636 | 53023050 |
| Personality change | 23.40 | 14.21 | 3 | 295377 | 6074 | 53047612 |
| Skin plaque | 23.22 | 14.21 | 4 | 295376 | 6500 | 53047186 |
| Nystagmus | 23.19 | 14.21 | 3 | 295377 | 6033 | 53047653 |
| Adverse reaction | 23.18 | 14.21 | 105 | 295275 | 8882 | 53044804 |
| Oral discomfort | 23.17 | 14.21 | 103 | 295277 | 8643 | 53045043 |
| Atrial septal defect | 23.11 | 14.21 | 5 | 295375 | 6909 | 53046777 |
| Epigastric discomfort | 23.07 | 14.21 | 81 | 295299 | 6092 | 53047594 |
| Shock haemorrhagic | 23.01 | 14.21 | 11 | 295369 | 9172 | 53044514 |
| Amylase increased | 22.98 | 14.21 | 3 | 295377 | 5991 | 53047695 |
| Arteriosclerosis coronary artery | 22.97 | 14.21 | 9 | 295371 | 8445 | 53045241 |
| Throat tightness | 22.95 | 14.21 | 56 | 295324 | 22160 | 53031526 |
| Dislocation of vertebra | 22.87 | 14.21 | 48 | 295332 | 2658 | 53051028 |
| Thinking abnormal | 22.85 | 14.21 | 15 | 295365 | 10493 | 53043193 |
| Back pain | 22.79 | 14.21 | 1062 | 294318 | 233185 | 52820501 |
| White blood cell count increased | 22.77 | 14.21 | 156 | 295224 | 46089 | 53007597 |
| Aortic arteriosclerosis | 22.58 | 14.21 | 3 | 295377 | 5911 | 53047775 |
| Pseudomonas infection | 22.52 | 14.21 | 15 | 295365 | 10413 | 53043273 |
| Polyneuropathy | 22.49 | 14.21 | 24 | 295356 | 13209 | 53040477 |
| Immune reconstitution inflammatory syndrome | 22.45 | 14.21 | 4 | 295376 | 6342 | 53047344 |
| Expired product administered | 22.38 | 14.21 | 3 | 295377 | 5873 | 53047813 |
| Pharyngeal abscess | 22.35 | 14.21 | 15 | 295365 | 231 | 53053455 |
| Enthesopathy | 22.27 | 14.21 | 83 | 295297 | 6428 | 53047258 |
| Amenorrhoea | 22.22 | 14.21 | 12 | 295368 | 9337 | 53044349 |
| Atrioventricular block | 22.22 | 14.21 | 6 | 295374 | 7134 | 53046552 |
| Dizziness postural | 22.20 | 14.21 | 5 | 295375 | 6720 | 53046966 |
| Injection site bruising | 22.19 | 14.21 | 120 | 295260 | 37526 | 53016160 |
| Impaired gastric emptying | 22.10 | 14.21 | 104 | 295276 | 8939 | 53044747 |
| Hepatitis cholestatic | 22.03 | 14.21 | 6 | 295374 | 7093 | 53046593 |
| Product label confusion | 21.98 | 14.21 | 20 | 295360 | 490 | 53053196 |
| Angina unstable | 21.92 | 14.21 | 7 | 295373 | 7461 | 53046225 |
| Pulseless electrical activity | 21.85 | 14.21 | 7 | 295373 | 7447 | 53046239 |
| Poor quality sleep | 21.82 | 14.21 | 39 | 295341 | 17284 | 53036402 |
| Hepatomegaly | 21.78 | 14.21 | 20 | 295360 | 11811 | 53041875 |
| Wrist deformity | 21.64 | 14.21 | 37 | 295343 | 1754 | 53051932 |
| Monocyte count increased | 21.60 | 14.21 | 75 | 295305 | 5610 | 53048076 |
| Rheumatic disorder | 21.54 | 14.21 | 34 | 295346 | 1507 | 53052179 |
| Hiatus hernia | 21.43 | 14.21 | 48 | 295332 | 19572 | 53034114 |
| Device failure | 21.41 | 14.21 | 4 | 295376 | 6131 | 53047555 |
| Acidosis | 21.28 | 14.21 | 19 | 295361 | 11373 | 53042313 |
| Neck surgery | 21.28 | 14.21 | 34 | 295346 | 1523 | 53052163 |
| Splenomegaly | 21.25 | 14.21 | 16 | 295364 | 10423 | 53043263 |
| Rheumatoid vasculitis | 21.23 | 14.21 | 17 | 295363 | 348 | 53053338 |
| Mouth ulceration | 21.15 | 14.21 | 252 | 295128 | 29074 | 53024612 |
| Gestational diabetes | 21.13 | 14.21 | 9 | 295371 | 8030 | 53045656 |
| Eyelid ptosis | 21.11 | 14.21 | 5 | 295375 | 6492 | 53047194 |
| Product complaint | 21.09 | 14.21 | 22 | 295358 | 12235 | 53041451 |
| Angina pectoris | 20.80 | 14.21 | 85 | 295295 | 28640 | 53025046 |
| Therapy change | 20.76 | 14.21 | 3 | 295377 | 5549 | 53048137 |
| Refusal of treatment by patient | 20.70 | 14.21 | 3 | 295377 | 5537 | 53048149 |
| Jaundice cholestatic | 20.67 | 14.21 | 3 | 295377 | 5531 | 53048155 |
| Coronary artery occlusion | 20.65 | 14.21 | 10 | 295370 | 8277 | 53045409 |
| Normal newborn | 20.59 | 14.21 | 7 | 295373 | 7172 | 53046514 |
| Lower limb fracture | 20.55 | 14.21 | 142 | 295238 | 14063 | 53039623 |
| Hepatic function abnormal | 20.46 | 14.21 | 120 | 295260 | 36779 | 53016907 |
| Laboratory test abnormal | 20.45 | 14.21 | 68 | 295312 | 24341 | 53029345 |
| Tooth infection | 20.44 | 14.21 | 143 | 295237 | 14220 | 53039466 |
| Photosensitivity reaction | 20.40 | 14.21 | 28 | 295352 | 13800 | 53039886 |
| Second primary malignancy | 20.38 | 14.21 | 7 | 295373 | 7125 | 53046561 |
| Obesity | 20.36 | 14.21 | 160 | 295220 | 16502 | 53037184 |
| Abscess rupture | 20.36 | 14.21 | 15 | 295365 | 270 | 53053416 |
| Stress cardiomyopathy | 20.34 | 14.21 | 11 | 295369 | 8551 | 53045135 |
| Body height decreased | 20.29 | 14.21 | 15 | 295365 | 9864 | 53043822 |
| Eye irritation | 20.26 | 14.21 | 45 | 295335 | 18404 | 53035282 |
| Secretion discharge | 20.21 | 14.21 | 113 | 295267 | 10393 | 53043293 |
| Injection site haemorrhage | 20.19 | 14.21 | 59 | 295321 | 21992 | 53031694 |
| Sensory disturbance | 20.13 | 14.21 | 25 | 295355 | 12861 | 53040825 |
| Product temperature excursion issue | 20.00 | 14.21 | 8 | 295372 | 37 | 53053649 |
| Drug dependence | 19.99 | 14.21 | 57 | 295323 | 21415 | 53032271 |
| Partial seizures | 19.90 | 14.21 | 3 | 295377 | 5377 | 53048309 |
| Increased appetite | 19.87 | 14.21 | 13 | 295367 | 9109 | 53044577 |
| Extra dose administered | 19.85 | 14.21 | 3 | 295377 | 5367 | 53048319 |
| Middle insomnia | 19.83 | 14.21 | 18 | 295362 | 10690 | 53042996 |
| Hyperventilation | 19.72 | 14.21 | 5 | 295375 | 6199 | 53047487 |
| Lipase increased | 19.58 | 14.21 | 14 | 295366 | 9364 | 53044322 |
| Infected skin ulcer | 19.57 | 14.21 | 41 | 295339 | 2268 | 53051418 |
| Swollen tongue | 19.49 | 14.21 | 97 | 295283 | 30983 | 53022703 |
| Intervertebral disc compression | 19.45 | 14.21 | 26 | 295354 | 989 | 53052697 |
| Tendon disorder | 19.41 | 14.21 | 72 | 295308 | 5563 | 53048123 |
| Pleurisy | 19.36 | 14.21 | 92 | 295288 | 7939 | 53045747 |
| Pancreatic toxicity | 19.35 | 14.21 | 7 | 295373 | 23 | 53053663 |
| Injection site induration | 19.32 | 14.21 | 12 | 295368 | 8646 | 53045040 |
| Sputum discoloured | 19.24 | 14.21 | 31 | 295349 | 14308 | 53039378 |
| Purpura | 19.22 | 14.21 | 19 | 295361 | 10834 | 53042852 |
| Eye pruritus | 19.15 | 14.21 | 28 | 295352 | 13441 | 53040245 |
| Androgenetic alopecia | 19.10 | 14.21 | 12 | 295368 | 164 | 53053522 |
| Micturition urgency | 19.09 | 14.21 | 12 | 295368 | 8590 | 53045096 |
| Drug-induced liver injury | 19.04 | 14.21 | 90 | 295290 | 29143 | 53024543 |
| Blood thyroid stimulating hormone increased | 19.02 | 14.21 | 6 | 295374 | 6446 | 53047240 |
| Generalised oedema | 19.02 | 14.21 | 34 | 295346 | 15065 | 53038621 |
| Intervertebral disc space narrowing | 18.98 | 14.21 | 25 | 295355 | 937 | 53052749 |
| Faecaloma | 18.98 | 14.21 | 11 | 295369 | 8230 | 53045456 |
| Hyperbilirubinaemia | 18.89 | 14.21 | 20 | 295360 | 11049 | 53042637 |
| Amnesia | 18.88 | 14.21 | 160 | 295220 | 45128 | 53008558 |
| Blood pressure increased | 18.86 | 14.21 | 955 | 294425 | 139524 | 52914162 |
| Hypovolaemic shock | 18.80 | 14.21 | 4 | 295376 | 5593 | 53048093 |
| Initial insomnia | 18.79 | 14.21 | 3 | 295377 | 5152 | 53048534 |
| Embolism | 18.78 | 14.21 | 9 | 295371 | 7494 | 53046192 |
| Vaginal haematoma | 18.74 | 14.21 | 11 | 295369 | 132 | 53053554 |
| Bacteraemia | 18.71 | 14.21 | 36 | 295344 | 15513 | 53038173 |
| Aphthous ulcer | 18.58 | 14.21 | 114 | 295266 | 10844 | 53042842 |
| Infected bite | 18.40 | 14.21 | 30 | 295350 | 1367 | 53052319 |
| Asphyxia | 18.29 | 14.21 | 5 | 295375 | 5896 | 53047790 |
| Cerebral ischaemia | 18.27 | 14.21 | 7 | 295373 | 6658 | 53047028 |
| Protein total decreased | 18.20 | 14.21 | 5 | 295375 | 5878 | 53047808 |
| Oesophageal candidiasis | 18.14 | 14.21 | 4 | 295376 | 5456 | 53048230 |
| Restless legs syndrome | 18.12 | 14.21 | 43 | 295337 | 17180 | 53036506 |
| Hereditary angioedema | 18.11 | 14.21 | 6 | 295374 | 6247 | 53047439 |
| Metabolic disorder | 17.98 | 14.21 | 4 | 295376 | 5423 | 53048263 |
| Multiple system atrophy | 17.98 | 14.21 | 13 | 295367 | 227 | 53053459 |
| Jaw disorder | 17.94 | 14.21 | 4 | 295376 | 5414 | 53048272 |
| Thyroid disorder | 17.94 | 14.21 | 132 | 295248 | 13341 | 53040345 |
| Effusion | 17.93 | 14.21 | 32 | 295348 | 1570 | 53052116 |
| Ear discomfort | 17.91 | 14.21 | 9 | 295371 | 7292 | 53046394 |
| Injury | 17.86 | 14.21 | 188 | 295192 | 50783 | 53002903 |
| Hyperthyroidism | 17.79 | 14.21 | 28 | 295352 | 13045 | 53040641 |
| Synovial cyst | 17.76 | 14.21 | 93 | 295287 | 8343 | 53045343 |
| Klebsiella infection | 17.67 | 14.21 | 11 | 295369 | 7915 | 53045771 |
| Gastropleural fistula | 17.66 | 14.21 | 8 | 295372 | 53 | 53053633 |
| Wound infection | 17.64 | 14.21 | 125 | 295255 | 12482 | 53041204 |
| Lower respiratory tract congestion | 17.63 | 14.21 | 37 | 295343 | 2049 | 53051637 |
| Vaginal discharge | 17.60 | 14.21 | 5 | 295375 | 5748 | 53047938 |
| Cholecystectomy | 17.59 | 14.21 | 17 | 295363 | 9798 | 53043888 |
| Neck pain | 17.57 | 14.21 | 446 | 294934 | 59570 | 52994116 |
| Lower gastrointestinal haemorrhage | 17.57 | 14.21 | 10 | 295370 | 7556 | 53046130 |
| Gait inability | 17.54 | 14.21 | 304 | 295076 | 38007 | 53015679 |
| Hepatitis C | 17.53 | 14.21 | 7 | 295373 | 6494 | 53047192 |
| Haemolysis | 17.51 | 14.21 | 7 | 295373 | 6489 | 53047197 |
| Gastric disorder | 17.47 | 14.21 | 249 | 295131 | 29916 | 53023770 |
| Respiratory tract infection | 17.40 | 14.21 | 110 | 295270 | 33114 | 53020572 |
| Proctalgia | 17.36 | 14.21 | 4 | 295376 | 5292 | 53048394 |
| Exercise tolerance decreased | 17.35 | 14.21 | 4 | 295376 | 5291 | 53048395 |
| Urine abnormality | 17.35 | 14.21 | 7 | 295373 | 6453 | 53047233 |
| Rib fracture | 17.33 | 14.21 | 56 | 295324 | 20222 | 53033464 |
| Spinal cord infection | 17.30 | 14.21 | 19 | 295361 | 587 | 53053099 |
| Nasal congestion | 17.30 | 14.21 | 200 | 295180 | 53087 | 53000599 |
| Cerebral infarction | 17.28 | 14.21 | 73 | 295307 | 24371 | 53029315 |
| Pulmonary congestion | 17.26 | 14.21 | 40 | 295340 | 16116 | 53037570 |
| Pain in jaw | 17.26 | 14.21 | 143 | 295237 | 40526 | 53013160 |
| Odynophagia | 17.13 | 14.21 | 9 | 295371 | 7110 | 53046576 |
| Sleep disorder due to a general medical condition | 17.11 | 14.21 | 10 | 295370 | 7447 | 53046239 |
| Blood disorder | 17.09 | 14.21 | 6 | 295374 | 6024 | 53047662 |
| Disseminated large cell lymphoma | 17.06 | 14.21 | 8 | 295372 | 58 | 53053628 |
| Poor venous access | 17.06 | 14.21 | 104 | 295276 | 9871 | 53043815 |
| Rhinitis allergic | 17.03 | 14.21 | 11 | 295369 | 7762 | 53045924 |
| Large intestine polyp | 17.02 | 14.21 | 12 | 295368 | 8085 | 53045601 |
| Heart rate irregular | 16.93 | 14.21 | 57 | 295323 | 20327 | 53033359 |
| Head discomfort | 16.90 | 14.21 | 24 | 295356 | 11660 | 53042026 |
| Herpes simplex | 16.85 | 14.21 | 11 | 295369 | 7718 | 53045968 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 16.81 | 14.21 | 39 | 295341 | 2312 | 53051374 |
| Adenoiditis | 16.75 | 14.21 | 7 | 295373 | 37 | 53053649 |
| Emotional disorder | 16.72 | 14.21 | 29 | 295351 | 13001 | 53040685 |
| Metastasis | 16.69 | 14.21 | 3 | 295377 | 4728 | 53048958 |
| Epstein-Barr viraemia | 16.68 | 14.21 | 22 | 295358 | 826 | 53052860 |
| Dermatitis exfoliative | 16.66 | 14.21 | 6 | 295374 | 5930 | 53047756 |
| Iron deficiency | 16.64 | 14.21 | 7 | 295373 | 6293 | 53047393 |
| Onychoclasis | 16.57 | 14.21 | 5 | 295375 | 5528 | 53048158 |
| Hypofibrinogenaemia | 16.53 | 14.21 | 26 | 295354 | 1149 | 53052537 |
| Acute coronary syndrome | 16.52 | 14.21 | 20 | 295360 | 10404 | 53043282 |
| Post procedural haemorrhage | 16.50 | 14.21 | 12 | 295368 | 7956 | 53045730 |
| Movement disorder | 16.38 | 14.21 | 51 | 295329 | 18630 | 53035056 |
| Candida infection | 16.35 | 14.21 | 78 | 295302 | 25195 | 53028491 |
| Pneumonia fungal | 16.33 | 14.21 | 3 | 295377 | 4653 | 53049033 |
| Juvenile psoriatic arthritis | 16.30 | 14.21 | 6 | 295374 | 21 | 53053665 |
| Neutrophil count increased | 16.28 | 14.21 | 38 | 295342 | 15272 | 53038414 |
| Sexual abuse | 16.22 | 14.21 | 10 | 295370 | 132 | 53053554 |
| Lymphopenia | 16.21 | 14.21 | 44 | 295336 | 16799 | 53036887 |
| Decreased activity | 16.19 | 14.21 | 5 | 295375 | 5446 | 53048240 |
| Blood loss anaemia | 16.14 | 14.21 | 15 | 295365 | 8808 | 53044878 |
| Synovial rupture | 16.08 | 14.21 | 11 | 295369 | 175 | 53053511 |
| Dermatitis bullous | 16.00 | 14.21 | 13 | 295367 | 8150 | 53045536 |
| Squamous cell carcinoma of skin | 15.99 | 14.21 | 5 | 295375 | 5402 | 53048284 |
| Mental fatigue | 15.97 | 14.21 | 15 | 295365 | 383 | 53053303 |
| Fracture delayed union | 15.92 | 14.21 | 38 | 295342 | 2295 | 53051391 |
| Sudden death | 15.89 | 14.21 | 20 | 295360 | 10228 | 53043458 |
| Spinal osteoarthritis | 15.82 | 14.21 | 38 | 295342 | 15119 | 53038567 |
| Heparin-induced thrombocytopenia | 15.80 | 14.21 | 3 | 295377 | 4546 | 53049140 |
| Tuberculin test positive | 15.78 | 14.21 | 46 | 295334 | 3134 | 53050552 |
| Abnormal faeces | 15.73 | 14.21 | 3 | 295377 | 4531 | 53049155 |
| Thermal burn | 15.70 | 14.21 | 64 | 295316 | 5169 | 53048517 |
| Post procedural complication | 15.69 | 14.21 | 44 | 295336 | 16622 | 53037064 |
| Skin irritation | 15.64 | 14.21 | 14 | 295366 | 8370 | 53045316 |
| Azotaemia | 15.63 | 14.21 | 3 | 295377 | 4510 | 53049176 |
| Lacrimation increased | 15.61 | 14.21 | 49 | 295331 | 17854 | 53035832 |
| Gout | 15.54 | 14.21 | 28 | 295352 | 12371 | 53041315 |
| Rhinorrhoea | 15.54 | 14.21 | 206 | 295174 | 53372 | 53000314 |
| Localised oedema | 15.54 | 14.21 | 5 | 295375 | 5304 | 53048382 |
| Tooth loss | 15.52 | 14.21 | 9 | 295371 | 6730 | 53046956 |
| Gastric infection | 15.45 | 14.21 | 45 | 295335 | 3065 | 53050621 |
| Dermatitis acneiform | 15.42 | 14.21 | 3 | 295377 | 4467 | 53049219 |
| Upper-airway cough syndrome | 15.38 | 14.21 | 17 | 295363 | 9210 | 53044476 |
| Pulmonary alveolar haemorrhage | 15.32 | 14.21 | 3 | 295377 | 4447 | 53049239 |
| Coronary artery stenosis | 15.28 | 14.21 | 4 | 295376 | 4855 | 53048831 |
| Procedural pain | 15.28 | 14.21 | 37 | 295343 | 14680 | 53039006 |
| Pustular psoriasis | 15.27 | 14.21 | 55 | 295325 | 4189 | 53049497 |
| Low birth weight baby | 15.26 | 14.21 | 8 | 295372 | 6329 | 53047357 |
| Intercepted medication error | 15.22 | 14.21 | 16 | 295364 | 470 | 53053216 |
| Peroneal nerve palsy | 15.19 | 14.21 | 3 | 295377 | 4420 | 53049266 |
| Blood glucose abnormal | 15.18 | 14.21 | 11 | 295369 | 7308 | 53046378 |
| Tongue disorder | 15.15 | 14.21 | 93 | 295287 | 8848 | 53044838 |
| Escherichia urinary tract infection | 15.14 | 14.21 | 24 | 295356 | 11149 | 53042537 |
| Serum amyloid A protein increased | 15.12 | 14.21 | 9 | 295371 | 111 | 53053575 |
| Fluid retention | 15.12 | 14.21 | 211 | 295169 | 54190 | 52999496 |
| Petechiae | 15.09 | 14.21 | 33 | 295347 | 13572 | 53040114 |
| Neuralgia | 14.98 | 14.21 | 73 | 295307 | 23448 | 53030238 |
| Anosmia | 14.96 | 14.21 | 3 | 295377 | 4372 | 53049314 |
| Affective disorder | 14.88 | 14.21 | 6 | 295374 | 5533 | 53048153 |
| Vascular rupture | 14.84 | 14.21 | 27 | 295353 | 1345 | 53052341 |
| Breath sounds abnormal | 14.83 | 14.21 | 15 | 295365 | 8462 | 53045224 |
| Hyperammonaemia | 14.81 | 14.21 | 5 | 295375 | 5144 | 53048542 |
| Post-traumatic stress disorder | 14.81 | 14.21 | 4 | 295376 | 4754 | 53048932 |
| Hypertonia | 14.71 | 14.21 | 4 | 295376 | 4733 | 53048953 |
| Gastric haemorrhage | 14.64 | 14.21 | 8 | 295372 | 6183 | 53047503 |
| Ligament sprain | 14.64 | 14.21 | 109 | 295271 | 11057 | 53042629 |
| Cardiac valve disease | 14.60 | 14.21 | 3 | 295377 | 4299 | 53049387 |
| Thiopurine methyltransferase decreased | 14.47 | 14.21 | 13 | 295367 | 313 | 53053373 |
| Retinal haemorrhage | 14.42 | 14.21 | 5 | 295375 | 5060 | 53048626 |
| Headache | 14.39 | 14.21 | 2686 | 292694 | 534135 | 52519551 |
| Liver injury | 14.25 | 14.21 | 186 | 295194 | 21917 | 53031769 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 2020.60 | 14.70 | 1123 | 52631 | 43421 | 32416351 |
| Drug ineffective | 1703.92 | 14.70 | 2575 | 51179 | 380902 | 32078870 |
| Off label use | 1542.60 | 14.70 | 2185 | 51569 | 304135 | 32155637 |
| Joint swelling | 1072.14 | 14.70 | 797 | 52957 | 50938 | 32408834 |
| Intentional product use issue | 939.10 | 14.70 | 679 | 53075 | 41532 | 32418240 |
| Contraindicated product administered | 792.65 | 14.70 | 455 | 53299 | 18621 | 32441151 |
| Synovitis | 771.05 | 14.70 | 371 | 53383 | 10507 | 32449265 |
| Apparent death | 583.29 | 14.70 | 221 | 53533 | 3394 | 32456378 |
| Treatment failure | 535.91 | 14.70 | 474 | 53280 | 38689 | 32421083 |
| Diverticulitis | 518.41 | 14.70 | 347 | 53407 | 18681 | 32441091 |
| Bone erosion | 517.35 | 14.70 | 188 | 53566 | 2551 | 32457221 |
| Drug intolerance | 441.32 | 14.70 | 477 | 53277 | 49758 | 32410014 |
| Arthropathy | 411.06 | 14.70 | 322 | 53432 | 22167 | 32437605 |
| Therapeutic product effect decreased | 397.65 | 14.70 | 362 | 53392 | 30655 | 32429117 |
| C-reactive protein abnormal | 397.13 | 14.70 | 199 | 53555 | 6157 | 32453615 |
| No adverse event | 349.01 | 14.70 | 279 | 53475 | 19774 | 32439998 |
| Arthralgia | 344.68 | 14.70 | 758 | 52996 | 147690 | 32312082 |
| Red blood cell sedimentation rate abnormal | 333.43 | 14.70 | 129 | 53625 | 2101 | 32457671 |
| Drug eruption | 311.01 | 14.70 | 256 | 53498 | 18910 | 32440862 |
| Pain | 297.84 | 14.70 | 828 | 52926 | 186728 | 32273044 |
| Stomatitis | 281.95 | 14.70 | 340 | 53414 | 39889 | 32419883 |
| Urticaria | 263.96 | 14.70 | 403 | 53351 | 59211 | 32400561 |
| Toxicity to various agents | 235.43 | 14.70 | 15 | 53739 | 178026 | 32281746 |
| Red blood cell sedimentation rate increased | 232.97 | 14.70 | 151 | 53603 | 7684 | 32452088 |
| Hypersensitivity | 211.23 | 14.70 | 358 | 53396 | 57400 | 32402372 |
| Pain in extremity | 203.36 | 14.70 | 540 | 53214 | 118361 | 32341411 |
| Hepatic function abnormal | 191.19 | 14.70 | 298 | 53456 | 44542 | 32415230 |
| Drug hypersensitivity | 178.04 | 14.70 | 382 | 53372 | 73018 | 32386754 |
| Musculoskeletal stiffness | 173.05 | 14.70 | 265 | 53489 | 38999 | 32420773 |
| Diarrhoea | 173.02 | 14.70 | 210 | 53544 | 364592 | 32095180 |
| Peripheral swelling | 171.89 | 14.70 | 361 | 53393 | 67984 | 32391788 |
| Pulmonary thrombosis | 171.49 | 14.70 | 119 | 53635 | 6785 | 32452987 |
| Rheumatoid factor negative | 171.42 | 14.70 | 60 | 53694 | 724 | 32459048 |
| Loss of personal independence in daily activities | 170.54 | 14.70 | 216 | 53538 | 26617 | 32433155 |
| Ill-defined disorder | 160.58 | 14.70 | 143 | 53611 | 11746 | 32448026 |
| Knee arthroplasty | 158.51 | 14.70 | 107 | 53647 | 5830 | 32453942 |
| C-reactive protein increased | 151.08 | 14.70 | 279 | 53475 | 47823 | 32411949 |
| Anaemia | 147.70 | 14.70 | 94 | 53660 | 223530 | 32236242 |
| Bone cyst | 145.89 | 14.70 | 50 | 53704 | 564 | 32459208 |
| Mobility decreased | 136.96 | 14.70 | 200 | 53554 | 28209 | 32431563 |
| Acute kidney injury | 136.78 | 14.70 | 171 | 53583 | 293297 | 32166475 |
| Impaired work ability | 131.23 | 14.70 | 95 | 53659 | 5793 | 32453979 |
| Completed suicide | 131.06 | 14.70 | 5 | 53749 | 92512 | 32367260 |
| Overdose | 125.81 | 14.70 | 4 | 53750 | 87073 | 32372699 |
| Anti-cyclic citrullinated peptide antibody positive | 125.56 | 14.70 | 48 | 53706 | 755 | 32459017 |
| Haemophagocytic lymphohistiocytosis | 125.39 | 14.70 | 122 | 53632 | 11213 | 32448559 |
| Drug specific antibody present | 124.49 | 14.70 | 67 | 53687 | 2406 | 32457366 |
| Arthritis bacterial | 124.49 | 14.70 | 84 | 53670 | 4573 | 32455199 |
| Terminal state | 123.61 | 14.70 | 78 | 53676 | 3786 | 32455986 |
| Confusional state | 122.36 | 14.70 | 42 | 53712 | 143073 | 32316699 |
| Fatigue | 120.52 | 14.70 | 250 | 53504 | 350451 | 32109321 |
| Swelling | 120.37 | 14.70 | 222 | 53532 | 38000 | 32421772 |
| Epistaxis | 118.85 | 14.70 | 276 | 53478 | 55579 | 32404193 |
| Drug interaction | 118.30 | 14.70 | 112 | 53642 | 218073 | 32241699 |
| Mass | 110.84 | 14.70 | 96 | 53658 | 7596 | 32452176 |
| Infusion related reaction | 107.81 | 14.70 | 235 | 53519 | 45364 | 32414408 |
| Febrile neutropenia | 107.66 | 14.70 | 32 | 53722 | 119534 | 32340238 |
| Deep vein thrombosis | 107.32 | 14.70 | 288 | 53466 | 63425 | 32396347 |
| Vomiting | 106.79 | 14.70 | 140 | 53614 | 235417 | 32224355 |
| Dehydration | 106.55 | 14.70 | 40 | 53714 | 128918 | 32330854 |
| Pulmonary embolism | 105.40 | 14.70 | 341 | 53413 | 83318 | 32376454 |
| Interstitial lung disease | 101.71 | 14.70 | 286 | 53468 | 64715 | 32395057 |
| Skin ulcer | 99.83 | 14.70 | 146 | 53608 | 20613 | 32439159 |
| Joint ankylosis | 99.48 | 14.70 | 34 | 53720 | 380 | 32459392 |
| Limb discomfort | 98.90 | 14.70 | 102 | 53652 | 10052 | 32449720 |
| Death | 97.41 | 14.70 | 317 | 53437 | 382200 | 32077572 |
| Herpes zoster | 97.02 | 14.70 | 184 | 53570 | 32157 | 32427615 |
| Bladder transitional cell carcinoma | 95.41 | 14.70 | 57 | 53697 | 2506 | 32457266 |
| Hypofibrinogenaemia | 93.46 | 14.70 | 49 | 53705 | 1667 | 32458105 |
| COVID-19 | 93.40 | 14.70 | 180 | 53574 | 31835 | 32427937 |
| Juvenile idiopathic arthritis | 93.24 | 14.70 | 47 | 53707 | 1471 | 32458301 |
| Intestinal polyp | 90.68 | 14.70 | 40 | 53714 | 920 | 32458852 |
| Gastric disorder | 88.74 | 14.70 | 102 | 53652 | 11354 | 32448418 |
| Nodule | 86.91 | 14.70 | 71 | 53683 | 5181 | 32454591 |
| Malignant neoplasm progression | 84.73 | 14.70 | 14 | 53740 | 78482 | 32381290 |
| Joint lock | 82.89 | 14.70 | 40 | 53714 | 1137 | 32458635 |
| COVID-19 pneumonia | 78.51 | 14.70 | 84 | 53670 | 8636 | 32451136 |
| Nasopharyngitis | 77.60 | 14.70 | 257 | 53497 | 63530 | 32396242 |
| X-ray abnormal | 77.55 | 14.70 | 30 | 53724 | 488 | 32459284 |
| Cytology abnormal | 77.55 | 14.70 | 28 | 53726 | 372 | 32459400 |
| Cytokine release syndrome | 76.69 | 14.70 | 103 | 53651 | 13432 | 32446340 |
| Dizziness | 74.73 | 14.70 | 146 | 53608 | 209472 | 32250300 |
| Pyrexia | 74.69 | 14.70 | 275 | 53479 | 319693 | 32140079 |
| Hyponatraemia | 74.64 | 14.70 | 16 | 53738 | 74497 | 32385275 |
| Polyarthritis | 73.81 | 14.70 | 58 | 53696 | 4002 | 32455770 |
| Sleep disorder due to general medical condition, insomnia type | 73.76 | 14.70 | 38 | 53716 | 1246 | 32458526 |
| Physical disability | 73.56 | 14.70 | 38 | 53716 | 1253 | 32458519 |
| Asthenia | 72.85 | 14.70 | 178 | 53576 | 235766 | 32224006 |
| Dyspnoea | 72.75 | 14.70 | 330 | 53424 | 361715 | 32098057 |
| Joint arthroplasty | 72.65 | 14.70 | 31 | 53723 | 656 | 32459116 |
| Drug use disorder | 70.78 | 14.70 | 54 | 53700 | 3567 | 32456205 |
| Arthritis | 70.53 | 14.70 | 144 | 53610 | 26548 | 32433224 |
| Plasma cell myeloma | 70.05 | 14.70 | 7 | 53747 | 57607 | 32402165 |
| Constipation | 69.41 | 14.70 | 64 | 53690 | 126309 | 32333463 |
| Decreased appetite | 68.34 | 14.70 | 100 | 53654 | 160713 | 32299059 |
| Rheumatoid factor positive | 67.35 | 14.70 | 29 | 53725 | 628 | 32459144 |
| Cardiac failure congestive | 64.12 | 14.70 | 30 | 53724 | 84822 | 32374950 |
| Hepatitis B virus test positive | 63.57 | 14.70 | 22 | 53732 | 256 | 32459516 |
| Muscle spasms | 63.12 | 14.70 | 257 | 53497 | 70161 | 32389611 |
| Loss of consciousness | 62.87 | 14.70 | 29 | 53725 | 82678 | 32377094 |
| Blood pressure diastolic abnormal | 62.87 | 14.70 | 42 | 53712 | 2248 | 32457524 |
| Seizure | 62.66 | 14.70 | 48 | 53706 | 103806 | 32355966 |
| Rhabdomyolysis | 62.36 | 14.70 | 17 | 53737 | 67248 | 32392524 |
| Rheumatoid nodule | 61.13 | 14.70 | 40 | 53714 | 2067 | 32457705 |
| Intestinal sepsis | 60.59 | 14.70 | 24 | 53730 | 417 | 32459355 |
| Syncope | 60.58 | 14.70 | 37 | 53717 | 90087 | 32369685 |
| Hepatitis | 60.45 | 14.70 | 126 | 53628 | 23567 | 32436205 |
| Somnolence | 60.09 | 14.70 | 50 | 53704 | 103747 | 32356025 |
| Hyperkalaemia | 58.63 | 14.70 | 21 | 53733 | 69729 | 32390043 |
| Joint stiffness | 58.24 | 14.70 | 77 | 53677 | 9888 | 32449884 |
| Disability | 58.09 | 14.70 | 54 | 53700 | 4686 | 32455086 |
| Dysphagia | 58.01 | 14.70 | 15 | 53739 | 61461 | 32398311 |
| Depression | 57.12 | 14.70 | 46 | 53708 | 97014 | 32362758 |
| Photosensitivity reaction | 57.05 | 14.70 | 77 | 53677 | 10086 | 32449686 |
| Hypokalaemia | 56.89 | 14.70 | 11 | 53743 | 55083 | 32404689 |
| General physical health deterioration | 56.88 | 14.70 | 64 | 53690 | 115195 | 32344577 |
| Alanine aminotransferase abnormal | 56.50 | 14.70 | 44 | 53710 | 2996 | 32456776 |
| Drug effective for unapproved indication | 56.17 | 14.70 | 33 | 53721 | 1406 | 32458366 |
| Blood pressure diastolic decreased | 55.60 | 14.70 | 64 | 53690 | 7133 | 32452639 |
| Malaise | 53.55 | 14.70 | 135 | 53619 | 177003 | 32282769 |
| Localised infection | 52.62 | 14.70 | 92 | 53662 | 15095 | 32444677 |
| Gait inability | 51.60 | 14.70 | 107 | 53647 | 19940 | 32439832 |
| Lymphoedema | 50.83 | 14.70 | 45 | 53709 | 3665 | 32456107 |
| Skin laceration | 50.20 | 14.70 | 79 | 53675 | 11887 | 32447885 |
| Pulmonary fibrosis | 50.18 | 14.70 | 96 | 53658 | 16878 | 32442894 |
| Seronegative arthritis | 50.15 | 14.70 | 27 | 53727 | 970 | 32458802 |
| Fall | 50.14 | 14.70 | 162 | 53592 | 196039 | 32263733 |
| Hospitalisation | 50.10 | 14.70 | 10 | 53744 | 48961 | 32410811 |
| Prerenal failure | 50.04 | 14.70 | 35 | 53719 | 2020 | 32457752 |
| Disability assessment scale score increased | 49.71 | 14.70 | 16 | 53738 | 146 | 32459626 |
| Vision blurred | 49.68 | 14.70 | 7 | 53747 | 44179 | 32415593 |
| Anxiety | 48.80 | 14.70 | 52 | 53702 | 95953 | 32363819 |
| Liver function test increased | 48.70 | 14.70 | 80 | 53674 | 12480 | 32447292 |
| International normalised ratio increased | 48.14 | 14.70 | 11 | 53743 | 49024 | 32410748 |
| Coma | 47.32 | 14.70 | 7 | 53747 | 42605 | 32417167 |
| Osteolysis | 47.17 | 14.70 | 32 | 53722 | 1757 | 32458015 |
| Therapeutic product effect incomplete | 47.10 | 14.70 | 163 | 53591 | 41178 | 32418594 |
| Skin mass | 47.09 | 14.70 | 43 | 53711 | 3646 | 32456126 |
| Agitation | 46.81 | 14.70 | 18 | 53736 | 57218 | 32402554 |
| Oxygen saturation decreased | 46.66 | 14.70 | 180 | 53574 | 47919 | 32411853 |
| Immobile | 46.66 | 14.70 | 36 | 53718 | 2418 | 32457354 |
| Blood pressure diastolic increased | 46.13 | 14.70 | 42 | 53712 | 3548 | 32456224 |
| Wrong technique in product usage process | 46.11 | 14.70 | 3 | 53751 | 35056 | 32424716 |
| Immune effector cell-associated neurotoxicity syndrome | 46.06 | 14.70 | 30 | 53724 | 1538 | 32458234 |
| Mental status changes | 45.72 | 14.70 | 5 | 53749 | 38332 | 32421440 |
| Hallucination | 45.68 | 14.70 | 15 | 53739 | 52604 | 32407168 |
| Musculoskeletal pain | 45.64 | 14.70 | 136 | 53618 | 31761 | 32428011 |
| Gastrointestinal haemorrhage | 45.35 | 14.70 | 46 | 53708 | 86836 | 32372936 |
| Suicidal ideation | 45.33 | 14.70 | 5 | 53749 | 38078 | 32421694 |
| Hip arthroplasty | 45.15 | 14.70 | 44 | 53710 | 4050 | 32455722 |
| Infection | 44.83 | 14.70 | 266 | 53488 | 84449 | 32375323 |
| Oral surgery | 44.50 | 14.70 | 21 | 53733 | 567 | 32459205 |
| Blood pressure systolic abnormal | 44.45 | 14.70 | 33 | 53721 | 2091 | 32457681 |
| Abscess | 44.25 | 14.70 | 70 | 53684 | 10580 | 32449192 |
| Incorrect dose administered | 43.25 | 14.70 | 4 | 53750 | 35024 | 32424748 |
| Hypoglycaemia | 43.01 | 14.70 | 18 | 53736 | 54364 | 32405408 |
| Atrial fibrillation | 42.63 | 14.70 | 80 | 53674 | 116624 | 32343148 |
| Medical device implantation | 41.95 | 14.70 | 20 | 53734 | 553 | 32459219 |
| Hypotension | 41.48 | 14.70 | 200 | 53554 | 215910 | 32243862 |
| Blood glucose increased | 40.83 | 14.70 | 29 | 53725 | 65212 | 32394560 |
| Blood creatinine increased | 40.58 | 14.70 | 60 | 53694 | 96072 | 32363700 |
| Depressed level of consciousness | 40.43 | 14.70 | 9 | 53745 | 40838 | 32418934 |
| Drug tolerance decreased | 39.62 | 14.70 | 26 | 53728 | 1350 | 32458422 |
| Suicide attempt | 38.72 | 14.70 | 8 | 53746 | 38236 | 32421536 |
| Product dose omission issue | 38.63 | 14.70 | 69 | 53685 | 102506 | 32357266 |
| Hand deformity | 38.09 | 14.70 | 30 | 53724 | 2077 | 32457695 |
| Blood fibrinogen decreased | 37.89 | 14.70 | 23 | 53731 | 1041 | 32458731 |
| Poor venous access | 37.71 | 14.70 | 35 | 53719 | 3031 | 32456741 |
| Soft tissue swelling | 37.70 | 14.70 | 16 | 53738 | 334 | 32459438 |
| Fine motor skill dysfunction | 37.51 | 14.70 | 27 | 53727 | 1631 | 32458141 |
| Abdominal distension | 37.42 | 14.70 | 19 | 53735 | 51276 | 32408496 |
| Osteoarthritis | 37.12 | 14.70 | 93 | 53661 | 19626 | 32440146 |
| Haematuria | 36.67 | 14.70 | 17 | 53737 | 48344 | 32411428 |
| Dysarthria | 35.63 | 14.70 | 6 | 53748 | 33195 | 32426577 |
| Bronchopulmonary aspergillosis | 35.15 | 14.70 | 73 | 53681 | 13614 | 32446158 |
| Aggression | 34.59 | 14.70 | 11 | 53743 | 39378 | 32420394 |
| Lactic acidosis | 33.98 | 14.70 | 7 | 53747 | 33529 | 32426243 |
| Myalgia | 32.08 | 14.70 | 53 | 53701 | 81177 | 32378595 |
| Interleukin level increased | 31.97 | 14.70 | 9 | 53745 | 49 | 32459723 |
| Metabolic acidosis | 31.34 | 14.70 | 14 | 53740 | 40685 | 32419087 |
| Abscess limb | 31.05 | 14.70 | 33 | 53721 | 3365 | 32456407 |
| Abdominal pain | 30.66 | 14.70 | 135 | 53619 | 149394 | 32310378 |
| Amnesia | 30.53 | 14.70 | 3 | 53751 | 25033 | 32434739 |
| Bursitis | 30.43 | 14.70 | 40 | 53714 | 5106 | 32454666 |
| Renal impairment | 30.21 | 14.70 | 67 | 53687 | 91905 | 32367867 |
| Abnormal behaviour | 30.20 | 14.70 | 4 | 53750 | 26462 | 32433310 |
| Pulmonary toxicity | 30.07 | 14.70 | 39 | 53715 | 4914 | 32454858 |
| Haematemesis | 29.64 | 14.70 | 5 | 53749 | 27630 | 32432142 |
| Blood pressure systolic increased | 29.61 | 14.70 | 79 | 53675 | 17317 | 32442455 |
| Coronary artery disease | 28.67 | 14.70 | 24 | 53730 | 49682 | 32410090 |
| Thrombocytopenia | 27.97 | 14.70 | 138 | 53616 | 148161 | 32311611 |
| Unresponsive to stimuli | 27.49 | 14.70 | 6 | 53748 | 27603 | 32432169 |
| Pneumatosis intestinalis | 27.41 | 14.70 | 31 | 53723 | 3389 | 32456383 |
| Hepatic steatosis | 27.19 | 14.70 | 73 | 53681 | 16060 | 32443712 |
| Cardio-respiratory arrest | 26.61 | 14.70 | 32 | 53722 | 55957 | 32403815 |
| Disorientation | 26.52 | 14.70 | 11 | 53743 | 33414 | 32426358 |
| Pancytopenia | 26.40 | 14.70 | 71 | 53683 | 91164 | 32368608 |
| Urinary retention | 26.37 | 14.70 | 13 | 53741 | 35684 | 32424088 |
| Chronic kidney disease | 26.03 | 14.70 | 17 | 53737 | 39958 | 32419814 |
| Skin exfoliation | 26.01 | 14.70 | 5 | 53749 | 25152 | 32434620 |
| Thrombosis | 25.70 | 14.70 | 146 | 53608 | 45608 | 32414164 |
| Rheumatoid factor increased | 25.58 | 14.70 | 14 | 53740 | 520 | 32459252 |
| Cytokine storm | 25.47 | 14.70 | 15 | 53739 | 642 | 32459130 |
| Infectious pleural effusion | 25.29 | 14.70 | 24 | 53730 | 2137 | 32457635 |
| Irritability | 25.28 | 14.70 | 5 | 53749 | 24649 | 32435123 |
| Joint injury | 25.20 | 14.70 | 45 | 53709 | 7505 | 32452267 |
| Heart rate decreased | 25.00 | 14.70 | 95 | 53659 | 25105 | 32434667 |
| Lethargy | 24.91 | 14.70 | 19 | 53735 | 41209 | 32418563 |
| Rheumatoid factor | 24.76 | 14.70 | 8 | 53746 | 74 | 32459698 |
| Muscle strain | 24.48 | 14.70 | 31 | 53723 | 3814 | 32455958 |
| Ulcerative keratitis | 23.82 | 14.70 | 20 | 53734 | 1516 | 32458256 |
| Nephrolithiasis | 23.82 | 14.70 | 99 | 53655 | 27255 | 32432517 |
| Mucosal inflammation | 23.48 | 14.70 | 13 | 53741 | 33421 | 32426351 |
| Stent placement | 23.18 | 14.70 | 33 | 53721 | 4542 | 32455230 |
| Intercepted product storage error | 23.12 | 14.70 | 9 | 53745 | 149 | 32459623 |
| Haematocrit decreased | 22.69 | 14.70 | 12 | 53742 | 31650 | 32428122 |
| Gastrointestinal perforation | 22.64 | 14.70 | 30 | 53724 | 3860 | 32455912 |
| Hepatic enzyme abnormal | 22.48 | 14.70 | 24 | 53730 | 2460 | 32457312 |
| Tubulointerstitial nephritis | 22.24 | 14.70 | 3 | 53751 | 19574 | 32440198 |
| Inappropriate schedule of product administration | 21.98 | 14.70 | 26 | 53728 | 45799 | 32413973 |
| Infective chondritis | 21.56 | 14.70 | 5 | 53749 | 10 | 32459762 |
| Drug ineffective for unapproved indication | 21.51 | 14.70 | 61 | 53693 | 13851 | 32445921 |
| Toxic epidermal necrolysis | 21.49 | 14.70 | 4 | 53750 | 20589 | 32439183 |
| Neuropathy peripheral | 21.45 | 14.70 | 61 | 53693 | 76921 | 32382851 |
| Joint effusion | 21.44 | 14.70 | 31 | 53723 | 4328 | 32455444 |
| Long QT syndrome | 21.34 | 14.70 | 24 | 53730 | 2607 | 32457165 |
| Therapy partial responder | 21.30 | 14.70 | 33 | 53721 | 4897 | 32454875 |
| Excessive cerumen production | 20.99 | 14.70 | 10 | 53744 | 276 | 32459496 |
| Pharyngitis | 20.68 | 14.70 | 42 | 53712 | 7708 | 32452064 |
| Respiratory arrest | 20.65 | 14.70 | 11 | 53743 | 28897 | 32430875 |
| Disease progression | 20.59 | 14.70 | 74 | 53680 | 86788 | 32372984 |
| Septic arthritis staphylococcal | 20.54 | 14.70 | 12 | 53742 | 506 | 32459266 |
| Large intestine perforation | 20.45 | 14.70 | 43 | 53711 | 8087 | 32451685 |
| Blood cholesterol abnormal | 20.18 | 14.70 | 18 | 53736 | 1480 | 32458292 |
| Oral disorder | 20.16 | 14.70 | 30 | 53724 | 4298 | 32455474 |
| Septic shock | 20.06 | 14.70 | 188 | 53566 | 68801 | 32390971 |
| Infective spondylitis | 19.97 | 14.70 | 9 | 53745 | 218 | 32459554 |
| Treatment noncompliance | 19.95 | 14.70 | 10 | 53744 | 27192 | 32432580 |
| Ankle operation | 19.53 | 14.70 | 9 | 53745 | 230 | 32459542 |
| Cardiac arrest | 19.44 | 14.70 | 88 | 53666 | 96688 | 32363084 |
| Osteonecrosis of jaw | 19.42 | 14.70 | 4 | 53750 | 19162 | 32440610 |
| Lower respiratory tract congestion | 19.39 | 14.70 | 16 | 53738 | 1184 | 32458588 |
| Hepatic enzyme increased | 19.37 | 14.70 | 116 | 53638 | 36921 | 32422851 |
| Oedema | 19.21 | 14.70 | 28 | 53726 | 45119 | 32414653 |
| Alveolar proteinosis | 19.10 | 14.70 | 10 | 53744 | 339 | 32459433 |
| Liver disorder | 19.10 | 14.70 | 103 | 53651 | 31551 | 32428221 |
| Panniculitis | 19.09 | 14.70 | 16 | 53738 | 1210 | 32458562 |
| Jaundice | 19.08 | 14.70 | 17 | 53737 | 34141 | 32425631 |
| Condition aggravated | 18.97 | 14.70 | 362 | 53392 | 155299 | 32304473 |
| Drug withdrawal syndrome | 18.95 | 14.70 | 5 | 53749 | 20226 | 32439546 |
| Hypomagnesaemia | 18.89 | 14.70 | 4 | 53750 | 18801 | 32440971 |
| Chills | 18.85 | 14.70 | 66 | 53688 | 78018 | 32381754 |
| Joint destruction | 18.84 | 14.70 | 9 | 53745 | 250 | 32459522 |
| Haemorrhage | 18.84 | 14.70 | 33 | 53721 | 49415 | 32410357 |
| Nausea | 18.57 | 14.70 | 397 | 53357 | 320452 | 32139320 |
| Disturbance in attention | 18.55 | 14.70 | 8 | 53746 | 23745 | 32436027 |
| Diverticular perforation | 18.53 | 14.70 | 25 | 53729 | 3273 | 32456499 |
| Diabetes mellitus | 18.47 | 14.70 | 133 | 53621 | 45040 | 32414732 |
| White blood cell count increased | 18.29 | 14.70 | 25 | 53729 | 41377 | 32418395 |
| Polyarteritis nodosa | 18.26 | 14.70 | 9 | 53745 | 268 | 32459504 |
| Respiratory tract infection bacterial | 18.15 | 14.70 | 12 | 53742 | 631 | 32459141 |
| Delirium | 18.08 | 14.70 | 28 | 53726 | 44018 | 32415754 |
| Red blood cell sedimentation rate | 18.08 | 14.70 | 11 | 53743 | 500 | 32459272 |
| Angioedema | 18.04 | 14.70 | 20 | 53734 | 36269 | 32423503 |
| Hepatic cirrhosis | 18.03 | 14.70 | 65 | 53689 | 16744 | 32443028 |
| Intestinal perforation | 17.91 | 14.70 | 43 | 53711 | 8832 | 32450940 |
| JC virus CSF test positive | 17.87 | 14.70 | 7 | 53747 | 118 | 32459654 |
| Body temperature decreased | 17.72 | 14.70 | 49 | 53705 | 10965 | 32448807 |
| Fluid retention | 17.68 | 14.70 | 11 | 53743 | 26539 | 32433233 |
| Suture rupture | 17.64 | 14.70 | 10 | 53744 | 398 | 32459374 |
| Visual impairment | 17.62 | 14.70 | 17 | 53737 | 32871 | 32426901 |
| Pulmonary hypertension | 17.50 | 14.70 | 6 | 53748 | 20488 | 32439284 |
| Therapeutic response decreased | 17.48 | 14.70 | 87 | 53667 | 25833 | 32433939 |
| Myocardial ischaemia | 17.39 | 14.70 | 4 | 53750 | 17755 | 32442017 |
| Giant cell arteritis | 17.30 | 14.70 | 13 | 53741 | 839 | 32458933 |
| Hyperglycaemia | 17.14 | 14.70 | 23 | 53731 | 38368 | 32421404 |
| Neutrophil count increased | 17.10 | 14.70 | 3 | 53751 | 16111 | 32443661 |
| Inflammation | 17.08 | 14.70 | 83 | 53671 | 24410 | 32435362 |
| Paraesthesia | 16.94 | 14.70 | 46 | 53708 | 58898 | 32400874 |
| Oesophageal rupture | 16.94 | 14.70 | 10 | 53744 | 430 | 32459342 |
| Cholestasis | 16.92 | 14.70 | 12 | 53742 | 27021 | 32432751 |
| Squamous cell carcinoma of lung | 16.91 | 14.70 | 18 | 53736 | 1839 | 32457933 |
| Therapy non-responder | 16.91 | 14.70 | 102 | 53652 | 32552 | 32427220 |
| Gastrointestinal disorder | 16.90 | 14.70 | 98 | 53656 | 30833 | 32428939 |
| Weight increased | 16.90 | 14.70 | 212 | 53542 | 83451 | 32376321 |
| Blood pressure increased | 16.86 | 14.70 | 203 | 53551 | 79151 | 32380621 |
| Hypophagia | 16.85 | 14.70 | 9 | 53745 | 23614 | 32436158 |
| Human herpesvirus 6 encephalitis | 16.85 | 14.70 | 8 | 53746 | 219 | 32459553 |
| Stevens-Johnson syndrome | 16.83 | 14.70 | 5 | 53749 | 18704 | 32441068 |
| Dyspnoea exertional | 16.73 | 14.70 | 24 | 53730 | 38937 | 32420835 |
| Nasal crusting | 16.71 | 14.70 | 10 | 53744 | 441 | 32459331 |
| Chest pain | 16.39 | 14.70 | 129 | 53625 | 124008 | 32335764 |
| Solar urticaria | 16.36 | 14.70 | 4 | 53750 | 11 | 32459761 |
| Oropharyngeal pain | 16.27 | 14.70 | 98 | 53656 | 31254 | 32428518 |
| Local reaction | 16.27 | 14.70 | 6 | 53748 | 85 | 32459687 |
| Enterobacter pneumonia | 16.22 | 14.70 | 5 | 53749 | 39 | 32459733 |
| Anorectal agenesis | 16.22 | 14.70 | 3 | 53751 | 0 | 32459772 |
| Gait disturbance | 16.21 | 14.70 | 73 | 53681 | 80335 | 32379437 |
| Bradycardia foetal | 16.04 | 14.70 | 9 | 53745 | 351 | 32459421 |
| Blood potassium increased | 16.04 | 14.70 | 4 | 53750 | 16800 | 32442972 |
| Disseminated strongyloidiasis | 16.02 | 14.70 | 6 | 53748 | 89 | 32459683 |
| Bursitis infective staphylococcal | 15.86 | 14.70 | 4 | 53750 | 13 | 32459759 |
| Intentional product misuse | 15.69 | 14.70 | 22 | 53732 | 36029 | 32423743 |
| Oral herpes | 15.68 | 14.70 | 29 | 53725 | 4968 | 32454804 |
| Blood alkaline phosphatase increased | 15.65 | 14.70 | 18 | 53736 | 32114 | 32427658 |
| Rheumatoid lung | 15.52 | 14.70 | 9 | 53745 | 374 | 32459398 |
| Listeria encephalitis | 15.50 | 14.70 | 5 | 53749 | 46 | 32459726 |
| Medication error | 15.48 | 14.70 | 9 | 53745 | 22526 | 32437246 |
| Head injury | 15.38 | 14.70 | 5 | 53749 | 17658 | 32442114 |
| Post procedural infection | 15.31 | 14.70 | 28 | 53726 | 4757 | 32455015 |
| Polychondritis | 15.29 | 14.70 | 7 | 53747 | 176 | 32459596 |
| Faeces discoloured | 15.29 | 14.70 | 3 | 53751 | 14874 | 32444898 |
| Scalloped tongue | 15.22 | 14.70 | 4 | 53750 | 16 | 32459756 |
| Ventricular tachycardia | 15.16 | 14.70 | 12 | 53742 | 25544 | 32434228 |
| Ascites | 15.15 | 14.70 | 27 | 53727 | 40164 | 32419608 |
| Pollakiuria | 15.14 | 14.70 | 6 | 53748 | 18738 | 32441034 |
| Circulatory collapse | 15.14 | 14.70 | 8 | 53746 | 21117 | 32438655 |
| Injury | 15.12 | 14.70 | 9 | 53745 | 22236 | 32437536 |
| Epstein-Barr viraemia | 15.04 | 14.70 | 13 | 53741 | 1025 | 32458747 |
| Vertigo | 14.91 | 14.70 | 11 | 53743 | 24272 | 32435500 |
| Presyncope | 14.89 | 14.70 | 5 | 53749 | 17296 | 32442476 |
| Cellulitis gangrenous | 14.87 | 14.70 | 7 | 53747 | 188 | 32459584 |
| Product prescribing error | 14.84 | 14.70 | 7 | 53747 | 19710 | 32440062 |
| Erysipelas | 14.77 | 14.70 | 28 | 53726 | 4888 | 32454884 |
| Hypocalcaemia | 14.74 | 14.70 | 10 | 53744 | 23044 | 32436728 |
| Speech disorder | 14.74 | 14.70 | 13 | 53741 | 26240 | 32433532 |
| Dry mouth | 14.72 | 14.70 | 11 | 53743 | 24108 | 32435664 |
| Source | Code | Description |
|---|---|---|
| ATC | L04AC07 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors |
| FDA MoA | N0000190478 | Interleukin 6 Receptor Antagonists |
| FDA EPC | N0000190480 | Interleukin-6 Receptor Antagonist |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
| Castleman's disease | indication | 207036003 | DOID:0111157 |
| Still's disease | indication | 410794002 | |
| Juvenile rheumatoid arthritis | indication | 410795001 | |
| Giant cell arteritis | indication | 414341000 | DOID:13375 |
| Cytokine release syndrome induced by tumor-specific T-cell infusion therapy | indication | 710027002 | |
| Coronavirus infection | off-label use | 186747009 |
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Interleukin-6 receptor | Membrane receptor | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| D02596 | KEGG_DRUG |
| 4029705 | VUID |
| N0000180629 | NUI |
| 4029705 | VANDF |
| CHEMBL1237022 | ChEMBL_ID |
| C502936 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6881 | IUPHAR_LIGAND_ID |
| 8394 | INN_ID |
| DB06273 | DRUGBANK_ID |
| I031V2H011 | UNII |
| 10150081 | PUBCHEM_CID |
| 612865 | RXNORM |
| 169600 | MMSL |
| 26778 | MMSL |
| d07496 | MMSL |
| 013198 | NDDF |
| 444648007 | SNOMEDCT_US |
| 444649004 | SNOMEDCT_US |
| C1609165 | UMLSCUI |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-135 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
| ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-136 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
| ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-137 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
| Actemra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-138 | INJECTION, SOLUTION | 180 mg | SUBCUTANEOUS | BLA | 33 sections |
| Actemra ACTPen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-143 | INJECTION, SOLUTION | 180 mg | SUBCUTANEOUS | BLA | 33 sections |