tocilizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 4933 375823-41-9

Description:

MoleculeDescription

Synonyms:

  • tocilizumab
  • MRA
  • RoActemra
  • actemra
  • R-1569
  • tocilizumab (genetical recombination)
A humanised anti-interleukin-6 receptor monoclonal antibody. Its potential to combat cytokine release syndrome (CRS) in patients with severely ill COVID-19 was investigated. Accordingly, it is recommended to use tocilizumabin combination with dexamethasone (or another corticosteroid at an equivalent dose) in certain hospitalized patients who are exhibiting rapid respiratory decompensation caused by COVID-19.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 16, 2009 EMA Chugai Pharmaceutical Co., Ltd
Jan. 8, 2010 FDA GENENTECH
March 6, 2008 PMDA Chugai Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Contraindicated product administered 4003.68 14.16 8009 678950 312130 89629358
Joint swelling 3213.08 14.16 9722 677237 493578 89447910
Drug ineffective 3046.96 14.16 19356 667603 1364942 88576546
Synovitis 3016.69 14.16 7278 679681 322474 89619014
Drug intolerance 2754.75 14.16 8539 678420 439052 89502436
Treatment failure 2650.20 14.16 6587 680372 297341 89644147
Arthropathy 2648.95 14.16 7402 679557 358840 89582648
Pemphigus 2362.48 14.16 6606 680353 320258 89621230
Systemic lupus erythematosus 2243.72 14.16 6925 680034 354971 89586517
Therapeutic product effect decreased 2226.00 14.16 5830 681129 271741 89669747
Glossodynia 2031.73 14.16 6198 680761 315581 89625907
Swelling 1991.91 14.16 7334 679625 411724 89529764
Hand deformity 1893.58 14.16 5733 681226 290629 89650859
Acute kidney injury 1549.18 14.16 279 686680 320108 89621380
Toxicity to various agents 1526.10 14.16 192 686767 287654 89653834
Hepatic enzyme increased 1481.93 14.16 6031 680928 354705 89586783
Wound 1470.13 14.16 5341 681618 297639 89643849
Anaemia 1422.29 14.16 452 686507 352350 89589138
Hypersensitivity 1418.54 14.16 7004 679955 447673 89493815
Abdominal discomfort 1416.18 14.16 7249 679710 470079 89471409
Drug interaction 1388.99 14.16 217 686742 276236 89665252
Infusion related reaction 1363.59 14.16 6509 680450 410271 89531217
Alopecia 1359.91 14.16 7360 679599 487711 89453777
Anti-cyclic citrullinated peptide antibody positive 1353.66 14.16 4405 682554 232028 89709460
Death 1339.84 14.16 910 686049 455641 89485847
Rheumatoid factor positive 1266.08 14.16 3498 683461 168152 89773336
Pericarditis 1202.33 14.16 4633 682326 265518 89675970
Arthralgia 1147.11 14.16 9923 677036 768599 89172889
Product dose omission issue 1141.52 14.16 393 686566 291294 89650194
Pain 1121.25 14.16 11995 674964 984346 88957142
Musculoskeletal stiffness 980.82 14.16 4648 682311 291884 89649604
Folliculitis 968.67 14.16 3577 683382 200776 89740712
Impaired healing 955.15 14.16 3909 683050 230290 89711198
Duodenal ulcer perforation 953.98 14.16 3758 683201 217530 89723958
Helicobacter infection 953.50 14.16 3822 683137 223028 89718460
Lower respiratory tract infection 953.14 14.16 4095 682864 246564 89694924
Ill-defined disorder 947.48 14.16 3320 683639 181571 89759917
Febrile neutropenia 918.24 14.16 75 686884 158274 89783214
Muscle injury 916.34 14.16 3185 683774 173469 89768019
Dehydration 904.10 14.16 186 686773 194261 89747227
C-reactive protein abnormal 895.18 14.16 2552 684407 124877 89816611
Infection 893.20 14.16 5233 681726 356861 89584627
Discomfort 872.30 14.16 4252 682707 270083 89671405
Irritable bowel syndrome 836.62 14.16 3451 683508 203997 89737491
Nausea 835.96 14.16 4972 681987 1105344 88836144
Peripheral swelling 822.38 14.16 5653 681306 407453 89534035
Constipation 795.19 14.16 579 686380 279816 89661672
Product use issue 790.88 14.16 4733 682226 325186 89616302
Blister 776.20 14.16 3904 683055 251094 89690394
Injection site pain 769.51 14.16 185 686774 173514 89767974
Rash 747.44 14.16 9260 677699 786840 89154648
Hyponatraemia 737.49 14.16 77 686882 133461 89808027
Somnolence 731.92 14.16 334 686625 208750 89732738
Sleep disorder due to general medical condition, insomnia type 718.79 14.16 2379 684580 126315 89815173
Seizure 713.61 14.16 144 686815 152485 89789003
Red blood cell sedimentation rate abnormal 700.90 14.16 891 686068 23313 89918175
Intentional overdose 692.22 14.16 3 686956 93831 89847657
Hypotension 653.90 14.16 907 686052 324490 89616998
Tremor 642.48 14.16 182 686777 152991 89788497
Rheumatic fever 619.20 14.16 2550 684409 150571 89790917
Malignant neoplasm progression 576.48 14.16 67 686892 106803 89834685
Maternal exposure during pregnancy 576.36 14.16 4681 682278 355382 89586106
Neuropathy peripheral 572.14 14.16 164 686795 136806 89804682
Blood cholesterol increased 564.72 14.16 3086 683873 204926 89736562
Psoriatic arthropathy 559.66 14.16 3296 683663 225039 89716449
Stomatitis 558.32 14.16 3780 683179 270918 89670570
Diarrhoea 551.65 14.16 4518 682441 934672 89006816
Inappropriate schedule of product administration 549.30 14.16 224 686735 149709 89791779
Cardiac arrest 546.05 14.16 74 686885 104861 89836627
Mobility decreased 542.66 14.16 3505 683454 247229 89694259
Drug hypersensitivity 537.61 14.16 5623 681336 457986 89483502
Renal failure 534.18 14.16 164 686795 130843 89810645
Red blood cell sedimentation rate increased 519.61 14.16 1591 685368 81004 89860484
Nasopharyngitis 513.80 14.16 5025 681934 402079 89539409
Loss of personal independence in daily activities 510.12 14.16 2215 684744 133890 89807598
Fall 504.96 14.16 1912 685047 479898 89461590
Cough 503.98 14.16 1298 685661 367664 89573824
Electrocardiogram QT prolonged 499.37 14.16 10 686949 72446 89869042
Fibromyalgia 491.61 14.16 2956 684003 203313 89738175
Suicide attempt 488.07 14.16 19 686940 75380 89866108
Urinary tract infection 487.13 14.16 989 685970 304643 89636845
Bradycardia 485.19 14.16 40 686919 83807 89857681
Type 2 diabetes mellitus 484.61 14.16 2913 684046 200331 89741157
Feeling abnormal 480.83 14.16 340 686619 166895 89774593
Cardiac failure congestive 476.38 14.16 86 686873 98608 89842880
Neutropenia 469.76 14.16 609 686350 224295 89717193
Swollen joint count increased 468.53 14.16 1876 685083 109330 89832158
Chest discomfort 462.77 14.16 235 686724 138130 89803358
Vision blurred 457.05 14.16 134 686825 110159 89831329
Balance disorder 454.96 14.16 91 686868 96989 89844499
C-reactive protein increased 447.96 14.16 2624 684335 178765 89762723
Depressed level of consciousness 440.44 14.16 28 686931 72756 89868732
Sinusitis 439.11 14.16 4248 682711 338840 89602648
Weight increased 437.18 14.16 4967 681992 412960 89528528
Dyspnoea 433.83 14.16 4429 682530 876526 89064962
Pancytopenia 428.75 14.16 187 686772 120076 89821412
Disease progression 421.29 14.16 341 686618 156274 89785214
Gastrointestinal disorder 418.43 14.16 3352 683607 253335 89688153
Inflammation 416.98 14.16 2546 684413 176046 89765442
Haemoglobin decreased 414.40 14.16 370 686589 161586 89779902
Hyperkalaemia 411.74 14.16 19 686940 64945 89876543
Atrial fibrillation 410.65 14.16 252 686707 133359 89808129
Hypoglycaemia 410.65 14.16 31 686928 69817 89871671
Intentional product use issue 407.76 14.16 2929 684030 213963 89727525
COVID-19 401.39 14.16 412 686547 168431 89773057
Cerebrovascular accident 395.21 14.16 222 686737 123311 89818177
Cognitive disorder 388.42 14.16 38 686921 69369 89872119
Liver injury 386.50 14.16 2413 684546 168154 89773334
Skin exfoliation 383.18 14.16 36 686923 67877 89873611
Pulmonary embolism 378.62 14.16 264 686695 130556 89810932
Cardiac failure 375.16 14.16 180 686779 109316 89832172
Dysphagia 374.99 14.16 191 686768 112087 89829401
Palpitations 374.91 14.16 292 686667 136436 89805052
Multiple sclerosis relapse 374.20 14.16 4 686955 52301 89889187
Sleep disorder 370.31 14.16 2671 684288 195359 89746129
Respiratory failure 370.00 14.16 219 686740 118199 89823289
Gastrointestinal haemorrhage 367.84 14.16 113 686846 90135 89851353
Coma 366.73 14.16 56 686903 72576 89868912
No adverse event 362.79 14.16 1238 685721 66744 89874744
Rheumatoid nodule 362.57 14.16 592 686367 19574 89921914
Hypokalaemia 362.06 14.16 278 686681 130838 89810650
Dry skin 361.27 14.16 109 686850 87964 89853524
Agitation 357.07 14.16 44 686915 67054 89874434
Metabolic acidosis 353.78 14.16 16 686943 55660 89885828
Incorrect dose administered 349.57 14.16 84 686875 78846 89862642
Rhabdomyolysis 349.56 14.16 8 686951 51248 89890240
Syncope 335.88 14.16 306 686653 132357 89809131
Wrong technique in product usage process 333.45 14.16 68 686891 71503 89869985
Hallucination 332.69 14.16 51 686908 65908 89875580
Myalgia 331.98 14.16 508 686451 174617 89766871
Cardio-respiratory arrest 329.72 14.16 44 686915 63096 89878392
Bone erosion 327.52 14.16 1015 685944 52006 89889482
Dysarthria 323.66 14.16 23 686936 54459 89887029
Bursitis 322.63 14.16 1901 685058 129753 89811735
Knee arthroplasty 321.75 14.16 1367 685592 81815 89859673
Blood iron abnormal 321.51 14.16 257 686702 3763 89937725
Hypoxia 318.77 14.16 78 686881 72321 89869167
Epistaxis 318.58 14.16 123 686836 85002 89856486
Suicidal ideation 316.65 14.16 84 686875 73771 89867717
Hip arthroplasty 313.25 14.16 1276 685683 74932 89866556
Rheumatoid arthritis 309.91 14.16 4150 682809 358464 89583024
Sepsis 308.02 14.16 557 686402 179257 89762231
Lactic acidosis 306.56 14.16 19 686940 50444 89891044
Dizziness 303.44 14.16 2929 684030 586355 89355133
Joint range of motion decreased 301.65 14.16 1910 685049 133733 89807755
Platelet count decreased 298.32 14.16 359 686600 136610 89804878
Chronic obstructive pulmonary disease 296.31 14.16 95 686864 73734 89867754
Sedation 296.08 14.16 17 686942 48154 89893334
Vomiting 294.05 14.16 4208 682751 784085 89157403
Disturbance in attention 291.48 14.16 16 686943 47093 89894395
Injection site erythema 291.40 14.16 194 686765 98308 89843180
Tachycardia 290.64 14.16 466 686493 157207 89784281
Lethargy 290.01 14.16 62 686897 63077 89878411
Musculoskeletal pain 285.79 14.16 2249 684710 169002 89772486
Thrombocytopenia 280.34 14.16 740 686219 207985 89733503
Joint stiffness 277.80 14.16 1251 685708 76791 89864697
Facet joint syndrome 277.77 14.16 1476 685483 96913 89844575
Anxiety 277.31 14.16 1305 685654 308467 89633021
Coeliac disease 276.47 14.16 855 686104 43755 89897733
Pulmonary fibrosis 276.21 14.16 1572 685387 105931 89835557
Blood glucose increased 275.87 14.16 192 686767 95054 89846434
Haematochezia 272.86 14.16 98 686861 70815 89870673
Chills 267.69 14.16 365 686594 131616 89809872
Hyperglycaemia 267.39 14.16 35 686924 50935 89890553
Osteoarthritis 267.26 14.16 2458 684501 193272 89748216
Deep vein thrombosis 266.27 14.16 184 686775 91436 89850052
Sciatica 265.42 14.16 1490 685469 99892 89841596
Colitis 265.17 14.16 99 686860 69843 89871645
Condition aggravated 262.62 14.16 6133 680826 589412 89352076
International normalised ratio increased 261.90 14.16 27 686932 47289 89894199
Neoplasm progression 257.98 14.16 21 686938 44465 89897023
Orthostatic hypotension 256.35 14.16 15 686944 41812 89899676
Blood pressure diastolic abnormal 254.06 14.16 503 686456 19378 89922110
Disorientation 252.59 14.16 22 686937 44092 89897396
Mucosal inflammation 251.91 14.16 63 686896 57562 89883926
Flushing 251.53 14.16 182 686777 88309 89853179
Dyspnoea exertional 248.89 14.16 118 686841 72170 89869318
Unresponsive to stimuli 245.38 14.16 10 686949 38111 89903377
Mental status changes 243.45 14.16 27 686932 44652 89896836
Plasma cell myeloma 243.21 14.16 17 686942 40811 89900677
Asthenia 236.87 14.16 2746 684213 531005 89410483
Pleural effusion 236.02 14.16 301 686658 111690 89829798
Dysgeusia 234.58 14.16 55 686904 52505 89888983
Immunodeficiency 233.87 14.16 791 686168 42443 89899045
Ascites 233.85 14.16 40 686919 47700 89893788
Myelosuppression 233.47 14.16 59 686900 53532 89887956
Injury 232.03 14.16 2402 684557 194947 89746541
Deformity 229.33 14.16 365 686594 11805 89929683
Grip strength decreased 226.91 14.16 1337 685622 91239 89850249
Prescribed overdose 223.44 14.16 1385 685574 96240 89845248
Blood pressure systolic abnormal 220.79 14.16 469 686490 19009 89922479
Angioedema 220.15 14.16 108 686851 64768 89876720
Generalised tonic-clonic seizure 218.63 14.16 11 686948 34892 89906596
Abdominal pain 218.48 14.16 1932 685027 393789 89547699
Depressed mood 217.43 14.16 56 686903 50166 89891322
Blood potassium decreased 214.88 14.16 49 686910 47678 89893810
Lip dry 213.01 14.16 1403 685556 99552 89841936
Bone pain 212.13 14.16 102 686857 61881 89879607
Hypomagnesaemia 211.46 14.16 15 686944 35573 89905915
Macular degeneration 209.29 14.16 22 686937 37948 89903540
Accidental exposure to product 208.61 14.16 35 686924 42331 89899157
Restlessness 206.75 14.16 17 686942 35703 89905785
Night sweats 206.01 14.16 1675 685284 127091 89814397
Aphasia 205.07 14.16 38 686921 42774 89898714
Foot deformity 204.69 14.16 946 686013 58705 89882783
Hypophagia 202.85 14.16 19 686940 35918 89905570
Blood bilirubin increased 201.04 14.16 42 686917 43428 89898060
Contusion 200.91 14.16 2842 684117 248374 89693114
Disability assessment scale score increased 199.27 14.16 194 686765 3737 89937751
Osteoporosis 198.52 14.16 1333 685626 95198 89846290
Toxic epidermal necrolysis 198.33 14.16 12 686947 32516 89908972
Respiratory arrest 198.04 14.16 14 686945 33297 89908191
Blood pressure decreased 197.70 14.16 166 686793 74729 89866759
Panniculitis 197.19 14.16 376 686583 14082 89927406
Encephalopathy 196.87 14.16 54 686905 46390 89895098
Pneumonia aspiration 196.83 14.16 36 686923 40904 89900584
Dyskinesia 196.74 14.16 23 686936 36511 89904977
Influenza like illness 195.73 14.16 193 686766 80418 89861070
Therapeutic product effect incomplete 195.34 14.16 2289 684670 191607 89749881
Blood parathyroid hormone decreased 194.88 14.16 340 686619 11876 89929612
Gait inability 194.71 14.16 1829 685130 144627 89796861
Hypercholesterolaemia 194.33 14.16 1371 685588 99521 89841967
Granuloma skin 193.98 14.16 315 686644 10365 89931123
General physical health deterioration 193.67 14.16 3773 683186 351342 89590146
Skin ulcer 193.65 14.16 823 686136 49252 89892236
Arthritis 193.59 14.16 2030 684929 165285 89776203
Eczema 191.92 14.16 80 686879 52790 89888698
Intentional self-injury 191.18 14.16 7 686952 29327 89912161
Pulmonary oedema 190.82 14.16 117 686842 61963 89879525
Blood calcium decreased 190.69 14.16 9 686950 30173 89911315
Injection site swelling 190.68 14.16 108 686851 59731 89881757
Drug level increased 190.61 14.16 4 686955 27758 89913730
Psychotic disorder 188.98 14.16 12 686947 31218 89910270
White blood cell count decreased 188.68 14.16 642 686317 166467 89775021
Wound infection 187.80 14.16 1416 685543 104986 89836502
Dysuria 186.54 14.16 36 686923 39365 89902123
Hypervolaemia 185.75 14.16 17 686942 32740 89908748
Blood alkaline phosphatase increased 185.73 14.16 66 686893 48013 89893475
Coronary artery disease 184.00 14.16 20 686939 33603 89907885
Emotional distress 183.40 14.16 29 686930 36633 89904855
Blood creatinine increased 182.72 14.16 304 686655 101082 89840406
Hemiparesis 181.82 14.16 16 686943 31803 89909685
Illness 181.49 14.16 212 686747 81757 89859731
Irritability 181.16 14.16 27 686932 35635 89905853
Acute respiratory failure 178.03 14.16 52 686907 42866 89898622
Osteonecrosis of jaw 176.33 14.16 40 686919 39063 89902425
Haematuria 176.22 14.16 27 686932 34910 89906578
Aggression 175.07 14.16 6 686953 26662 89914826
Obesity 174.49 14.16 1383 685576 104124 89837364
Joint destruction 174.42 14.16 340 686619 12947 89928541
Full blood count abnormal 174.19 14.16 33 686926 36564 89904924
Deep vein thrombosis postoperative 172.45 14.16 1021 685938 69788 89871700
Drug tolerance decreased 172.15 14.16 586 686373 31544 89909944
Overdose 170.59 14.16 617 686342 157092 89784396
Respiratory distress 169.42 14.16 43 686916 38903 89902585
Speech disorder 168.68 14.16 67 686892 45518 89895970
Drug reaction with eosinophilia and systemic symptoms 166.36 14.16 58 686901 42700 89898788
Eating disorder 166.32 14.16 12 686947 28061 89913427
Foetal exposure during pregnancy 165.99 14.16 59 686900 42916 89898572
Abortion spontaneous 165.97 14.16 102 686857 53954 89887534
Blood sodium decreased 165.93 14.16 11 686948 27602 89913886
Oedema peripheral 165.36 14.16 1209 685750 256706 89684782
Pollakiuria 165.35 14.16 26 686933 32979 89908509
Vertigo 165.09 14.16 171 686788 69640 89871848
Pulmonary hypertension 164.90 14.16 58 686901 42465 89899023
Neutrophil count decreased 162.72 14.16 181 686778 71351 89870137
Altered state of consciousness 162.20 14.16 23 686936 31509 89909979
Arrhythmia 162.01 14.16 59 686900 42273 89899215
Liver disorder 161.95 14.16 1516 685443 119753 89821735
Ear pain 161.02 14.16 863 686096 56839 89884649
Rash macular 160.75 14.16 20 686939 30260 89911228
Temperature regulation disorder 160.60 14.16 347 686612 14232 89927256
Transient ischaemic attack 160.52 14.16 63 686896 43113 89898375
Stevens-Johnson syndrome 159.42 14.16 18 686941 29358 89912130
Obstructive airways disorder 159.38 14.16 9 686950 25860 89915628
Sinus tachycardia 158.50 14.16 16 686943 28497 89912991
Breast cancer stage III 158.24 14.16 1140 685819 83307 89858181
Swelling face 157.96 14.16 232 686727 81120 89860368
Ventricular tachycardia 157.30 14.16 7 686952 24701 89916787
Chronic kidney disease 156.49 14.16 93 686866 50098 89891390
Pneumonia 156.24 14.16 3664 683295 634395 89307093
Paraesthesia oral 156.22 14.16 26 686933 31633 89909855
Ejection fraction decreased 156.17 14.16 11 686948 26242 89915246
Urinary retention 156.07 14.16 46 686913 37698 89903790
Hallucination, visual 155.94 14.16 4 686955 23088 89918400
Tubulointerstitial nephritis 155.58 14.16 9 686950 25334 89916154
Dermatitis atopic 155.08 14.16 5 686954 23467 89918021
Renal disorder 154.98 14.16 47 686912 37812 89903676
Cholestasis 154.24 14.16 42 686917 36257 89905231
Haemorrhage 154.02 14.16 179 686780 69190 89872298
Myocardial infarction 152.88 14.16 362 686597 105610 89835878
Lip swelling 152.60 14.16 51 686908 38559 89902929
Decreased appetite 152.51 14.16 1975 684984 374565 89566923
Abnormal behaviour 152.51 14.16 4 686955 22624 89918864
Pericardial effusion 152.10 14.16 45 686914 36788 89904700
Full blood count decreased 151.92 14.16 22 686937 29667 89911821
Diabetic ketoacidosis 151.90 14.16 8 686951 24399 89917089
Jaundice 151.24 14.16 31 686928 32486 89909002
Metastases to bone 150.82 14.16 11 686948 25494 89915994
Procedural pain 150.68 14.16 34 686925 33326 89908162
Thrombosis 150.10 14.16 201 686758 73050 89868438
Renal impairment 149.01 14.16 364 686595 105057 89836431
Presyncope 148.60 14.16 30 686929 31775 89909713
Sinus disorder 147.99 14.16 39 686920 34408 89907080
Bone marrow failure 147.23 14.16 32 686927 32189 89909299
Melaena 146.48 14.16 41 686918 34756 89906732
Hepatic failure 146.01 14.16 59 686900 39669 89901819
Blood pressure systolic increased 144.47 14.16 845 686114 57500 89883988
Device dislocation 142.37 14.16 32 686927 31450 89910038
Mental disorder 141.90 14.16 35 686924 32283 89909205
Treatment noncompliance 141.07 14.16 111 686848 51616 89889872
Peripheral venous disease 139.27 14.16 1101 685858 82820 89858668
Multiple organ dysfunction syndrome 138.51 14.16 189 686770 68147 89873341
Circulatory collapse 138.37 14.16 14 686945 24890 89916598
Electrolyte imbalance 138.26 14.16 11 686948 23734 89917754
Acute myocardial infarction 138.04 14.16 46 686913 34844 89906644
Diplopia 136.43 14.16 26 686933 28688 89912800
Muscle twitching 136.06 14.16 13 686946 24189 89917299
Withdrawal syndrome 135.26 14.16 9 686950 22515 89918973
Onychomycosis 135.12 14.16 602 686357 36774 89904714
Staphylococcal infection 134.57 14.16 102 686857 48337 89893151
Haematemesis 134.25 14.16 44 686915 33682 89907806
X-ray abnormal 134.05 14.16 690 686269 44734 89896754
Product prescribing error 133.62 14.16 32 686927 30113 89911375
Unevaluable event 133.52 14.16 131 686828 54717 89886771
Blood pressure diastolic decreased 133.10 14.16 477 686482 26349 89915139
Autoimmune disorder 132.98 14.16 1017 685942 75727 89865761
Nightmare 132.50 14.16 8 686951 21717 89919771
Food allergy 132.41 14.16 460 686499 25018 89916470
Intestinal obstruction 131.88 14.16 58 686901 37073 89904415
Accidental overdose 131.40 14.16 27 686932 28246 89913242
Lower limb fracture 130.64 14.16 1096 685863 83917 89857571
Cerebral haemorrhage 130.62 14.16 49 686910 34473 89907015
Blood urea increased 129.58 14.16 35 686924 30378 89911110
Inappropriate antidiuretic hormone secretion 129.42 14.16 4 686955 19501 89921987
Hospitalisation 128.29 14.16 517 686442 127583 89813905
Adverse event 127.58 14.16 1407 685552 116011 89825477
Pallor 126.77 14.16 50 686909 34115 89907373
Eye swelling 126.76 14.16 33 686926 29353 89912135
Liver function test increased 126.19 14.16 1086 685873 83769 89857719
Injection site pruritus 126.01 14.16 133 686826 53701 89887787
Dislocation of vertebra 125.51 14.16 790 686169 55178 89886310
Prescribed underdose 123.82 14.16 983 685976 74036 89867452
Urticaria 123.73 14.16 3175 683784 309559 89631929
Myoclonus 123.46 14.16 5 686954 19163 89922325
Erythema 123.40 14.16 1126 685833 228120 89713368
Onychomadesis 122.98 14.16 680 686279 45318 89896170
Skin necrosis 122.44 14.16 343 686616 16598 89924890
Upper gastrointestinal haemorrhage 122.40 14.16 15 686944 22961 89918527
Vaginal haemorrhage 122.38 14.16 42 686917 31229 89910259
Therapeutic response unexpected 122.35 14.16 12 686947 21868 89919620
Nervousness 121.26 14.16 53 686906 34003 89907485
Rhinorrhoea 120.87 14.16 310 686649 88006 89853482
Cardiac disorder 120.69 14.16 152 686807 56720 89884768
Small intestinal obstruction 120.45 14.16 11 686948 21223 89920265
Limb deformity 118.85 14.16 152 686807 4000 89937488
Cardiogenic shock 118.74 14.16 21 686938 24447 89917041
Infusion site pain 118.20 14.16 8 686951 19730 89921758
Swollen tongue 117.47 14.16 105 686854 45851 89895637
Back pain 117.45 14.16 1694 685265 315481 89626007
Female genital tract fistula 117.36 14.16 4 686955 17864 89923624
Gastritis 117.18 14.16 87 686872 41666 89899822
Eye pruritus 117.08 14.16 37 686922 28990 89912498
Urinary incontinence 116.56 14.16 70 686889 37496 89903992
Flatulence 116.34 14.16 86 686873 41281 89900207
Vaginal discharge 116.23 14.16 8 686951 19456 89922032
Clostridium difficile infection 116.08 14.16 65 686894 36180 89905308
Cardiomegaly 115.32 14.16 7 686952 18918 89922570
Premature delivery 115.08 14.16 76 686883 38686 89902802
Device issue 115.02 14.16 40 686919 29497 89911991
Motor dysfunction 114.56 14.16 8 686951 19222 89922266
Blood pressure diastolic increased 114.41 14.16 282 686677 12624 89928864
Musculoskeletal deformity 114.14 14.16 103 686856 1795 89939693
Coordination abnormal 113.62 14.16 14 686945 21342 89920146
Blood creatine phosphokinase increased 113.38 14.16 58 686901 33965 89907523
Adjustment disorder with depressed mood 113.25 14.16 778 686181 55975 89885513
Acute hepatic failure 112.50 14.16 18 686941 22543 89918945
Hypersomnia 112.42 14.16 15 686944 21516 89919972
Pulmonary arterial hypertension 111.83 14.16 30 686929 26157 89915331
Tenosynovitis 111.30 14.16 301 686658 14266 89927222
Tachypnoea 110.89 14.16 15 686944 21294 89920194
Metastases to liver 110.49 14.16 40 686919 28767 89912721
Haematoma 110.05 14.16 81 686878 38967 89902521
Haemophagocytic lymphohistiocytosis 109.77 14.16 311 686648 15148 89926340
Neutropenic sepsis 109.60 14.16 7 686952 18123 89923365
Nail disorder 107.55 14.16 792 686167 58275 89883213
Agranulocytosis 107.52 14.16 66 686893 34936 89906552
Respiratory tract infection 107.50 14.16 176 686783 58902 89882586
Hepatitis 106.05 14.16 907 686052 69832 89871656
Clostridium difficile colitis 106.02 14.16 35 686924 26671 89914817
Haematocrit decreased 105.23 14.16 97 686862 41735 89899753
Haemoptysis 104.92 14.16 61 686898 33259 89908229
Cholelithiasis 104.63 14.16 147 686812 52359 89889129
Caesarean section 104.38 14.16 10 686949 18567 89922921
Respiratory depression 104.05 14.16 3 686956 15572 89925916
Lung disorder 103.90 14.16 1655 685304 148228 89793260
Investigation abnormal 103.27 14.16 106 686853 2181 89939307
Oral candidiasis 103.27 14.16 71 686888 35384 89906104
Injection site mass 102.86 14.16 21 686938 22069 89919419
Gamma-glutamyltransferase increased 102.79 14.16 82 686877 37870 89903618
Injection site bruising 102.69 14.16 148 686811 52159 89889329
Therapeutic response decreased 102.46 14.16 1086 685873 88643 89852845
Exostosis 101.68 14.16 721 686238 52413 89889075
Leukocytosis 101.54 14.16 54 686905 30936 89910552
Poisoning 101.41 14.16 3 686956 15214 89926274
Blood lactate dehydrogenase increased 101.19 14.16 35 686924 25897 89915591
Premature baby 101.09 14.16 32 686927 25045 89916443
Ataxia 100.61 14.16 10 686949 18032 89923456
Hot flush 100.26 14.16 186 686773 59302 89882186
Skin haemorrhage 100.23 14.16 20 686939 21360 89920128
Dystonia 100.18 14.16 7 686952 16812 89924676
Hepatic cytolysis 99.65 14.16 55 686904 30861 89910627
Tinnitus 99.20 14.16 108 686851 42994 89898494
Anal incontinence 98.91 14.16 6 686953 16224 89925264
Sinus bradycardia 98.29 14.16 8 686951 16944 89924544
Proctitis 98.21 14.16 4 686955 15255 89926233
Mitral valve incompetence 97.72 14.16 25 686934 22499 89918989
Angina pectoris 97.10 14.16 92 686867 39068 89902420
Product dose omission in error 96.49 14.16 19 686940 20484 89921004
Visual acuity reduced 95.93 14.16 29 686930 23381 89918107
Schizophrenia 95.69 14.16 4 686955 14910 89926578
Hypophosphataemia 95.25 14.16 4 686955 14850 89926638
Body height below normal 95.22 14.16 99 686860 2069 89939419
Ageusia 94.87 14.16 7 686952 16069 89925419
Bronchitis chronic 94.57 14.16 146 686813 4597 89936891
Torsade de pointes 94.41 14.16 5 686954 15177 89926311
Mood altered 94.32 14.16 10 686949 17134 89924354
Radiculopathy 94.02 14.16 14 686945 18491 89922997
Productive cough 93.96 14.16 286 686673 76777 89864711
Faeces discoloured 93.78 14.16 23 686936 21297 89920191
Depression 93.71 14.16 1658 685301 298943 89642545
Dementia 93.46 14.16 32 686927 23829 89917659
Road traffic accident 93.45 14.16 1236 685723 106390 89835098
Rash papular 93.44 14.16 20 686939 20335 89921153
Immobile 93.00 14.16 171 686788 6227 89935261
Pulmonary toxicity 92.89 14.16 243 686716 11288 89930200
Injection site warmth 91.93 14.16 12 686947 17503 89923985
Anuria 91.77 14.16 5 686954 14813 89926675
Tricuspid valve incompetence 91.43 14.16 10 686949 16721 89924767
Hypothyroidism 91.42 14.16 164 686795 52963 89888525
Mental impairment 91.35 14.16 10 686949 16710 89924778
Pancreatitis acute 91.31 14.16 66 686893 32049 89909439
Sensory loss 91.09 14.16 14 686945 18061 89923427
Body temperature increased 91.04 14.16 616 686343 44094 89897394
Human antichimeric antibody positive 90.27 14.16 88 686871 1698 89939790
Oesophagitis 90.10 14.16 12 686947 17237 89924251
Face oedema 90.08 14.16 32 686927 23286 89918202
Right ventricular failure 89.96 14.16 18 686941 19187 89922301
Status epilepticus 89.86 14.16 17 686942 18857 89922631
Lymphocyte count decreased 89.68 14.16 80 686879 34970 89906518
Product administration error 89.62 14.16 44 686915 26379 89915109
Joint laxity 89.46 14.16 105 686854 2523 89938965
Nasal congestion 89.07 14.16 328 686631 83086 89858402
Finger deformity 89.06 14.16 488 686471 32409 89909079
Dysphonia 88.99 14.16 218 686741 62866 89878622
Lupus vulgaris 88.90 14.16 616 686343 44443 89897045
Joint dislocation 88.86 14.16 611 686348 43971 89897517
Blood pressure abnormal 88.77 14.16 20 686939 19625 89921863
Eosinophilia 88.77 14.16 53 686906 28480 89913008
Hypothermia 88.53 14.16 8 686951 15567 89925921
Hypertension 88.45 14.16 4278 682681 453254 89488234
Coagulopathy 88.20 14.16 33 686926 23256 89918232
Cyanosis 87.52 14.16 20 686939 19435 89922053
Acute myeloid leukaemia 87.47 14.16 24 686935 20616 89920872
Blood albumin decreased 87.03 14.16 12 686947 16791 89924697
Red blood cell sedimentation rate 86.80 14.16 139 686820 4519 89936969
Mania 86.75 14.16 5 686954 14119 89927369
Blood magnesium decreased 86.73 14.16 9 686950 15684 89925804
Respiratory disorder 86.36 14.16 810 686149 64006 89877482
Product substitution issue 86.21 14.16 16 686943 17992 89923496
Back injury 85.95 14.16 627 686332 45995 89895493
Blood glucose decreased 85.76 14.16 35 686924 23394 89918094
Drug ineffective for unapproved indication 85.11 14.16 242 686717 66402 89875086
Oral mucosal exfoliation 84.94 14.16 85 686874 1695 89939793
Incontinence 84.90 14.16 4 686955 13431 89928057
Cardiomyopathy 84.69 14.16 24 686935 20182 89921306
Joint injury 84.07 14.16 478 686481 32186 89909302
C-reactive protein 84.04 14.16 464 686495 30903 89910585
Iron deficiency anaemia 83.97 14.16 37 686922 23625 89917863
Hypoacusis 83.50 14.16 54 686905 27796 89913692
Skin discolouration 83.48 14.16 129 686830 44186 89897302
Fear 83.48 14.16 13 686946 16609 89924879
Shock 83.32 14.16 58 686901 28720 89912768
Ventricular fibrillation 83.20 14.16 6 686953 14038 89927450
Rectal haemorrhage 82.80 14.16 334 686625 82410 89859078
Hemiplegia 82.62 14.16 12 686947 16148 89925340
Sleep apnoea syndrome 81.78 14.16 72 686887 31675 89909813
Blepharospasm 81.59 14.16 708 686251 54737 89886751
Glomerular filtration rate decreased 81.15 14.16 15 686944 16917 89924571
Hyperlipidaemia 81.06 14.16 36 686923 22880 89918608
Skin burning sensation 80.90 14.16 24 686935 19587 89921901
Muscle spasticity 80.70 14.16 501 686458 34821 89906667
Aplastic anaemia 80.58 14.16 5 686954 13264 89928224
Rhinitis allergic 80.17 14.16 15 686944 16770 89924718
Polyarthritis 79.98 14.16 313 686646 18037 89923451
Brain oedema 79.97 14.16 17 686942 17368 89924120
Malnutrition 79.74 14.16 21 686938 18537 89922951
Anti-cyclic citrullinated peptide antibody 79.27 14.16 412 686547 26809 89914679
Metastases to lung 79.20 14.16 13 686946 15978 89925510
Sneezing 79.07 14.16 66 686893 29803 89911685
Device difficult to use 78.87 14.16 18 686941 17507 89923981
Myelodysplastic syndrome 78.53 14.16 30 686929 20873 89920615
Haematotoxicity 78.35 14.16 4 686955 12531 89928957
Blood calcium increased 78.16 14.16 3 686956 12055 89929433
Multiple sclerosis 78.13 14.16 58 686901 27782 89913706
Off label use 78.03 14.16 9515 677444 1092737 88848751
Acute generalised exanthematous pustulosis 77.99 14.16 7 686952 13696 89927792
Infusion site erythema 77.76 14.16 7 686952 13663 89927825
Drug tolerance 77.60 14.16 305 686654 17611 89923877
Therapy non-responder 77.27 14.16 1461 685498 135243 89806245
Hypokinesia 77.21 14.16 13 686946 15684 89925804
Left ventricular dysfunction 77.11 14.16 10 686949 14659 89926829
Neurotoxicity 77.08 14.16 33 686926 21434 89920054
Rheumatoid factor negative 75.98 14.16 51 686908 560 89940928
Chronic sinusitis 75.77 14.16 43 686916 23759 89917729
Injection site haemorrhage 75.67 14.16 62 686897 28256 89913232
Toxic skin eruption 75.55 14.16 14 686945 15760 89925728
Pain of skin 75.48 14.16 15 686944 16067 89925421
Disease recurrence 75.44 14.16 105 686854 37548 89903940
Ulcer 74.88 14.16 466 686493 32416 89909072
Musculoskeletal disorder 74.49 14.16 345 686614 21424 89920064
Injection site urticaria 74.37 14.16 22 686937 17989 89923499
Hepatic function abnormal 74.28 14.16 149 686810 46139 89895349
Hypoalbuminaemia 74.25 14.16 15 686944 15882 89925606
Eye pain 73.63 14.16 139 686820 44029 89897459
Diverticulitis 73.41 14.16 590 686369 44597 89896891
Cardiotoxicity 73.25 14.16 3 686956 11386 89930102
Subdural haematoma 73.13 14.16 18 686941 16627 89924861
Head injury 73.05 14.16 77 686882 31111 89910377
Retinitis 72.50 14.16 520 686439 37938 89903550
Atelectasis 72.27 14.16 48 686911 24361 89917127
Hyperhidrosis 71.79 14.16 673 686286 135632 89805856
Basal cell carcinoma 71.59 14.16 466 686493 32923 89908565
Delusion 71.41 14.16 10 686949 13830 89927658
Breast cancer metastatic 71.26 14.16 14 686945 15118 89926370
Product label confusion 70.85 14.16 352 686607 22498 89918990
Dysstasia 70.56 14.16 52 686907 25000 89916488
Hypotonia 70.31 14.16 4 686955 11422 89930066
Lung infiltration 70.18 14.16 15 686944 15267 89926221
Chest pain 70.05 14.16 1865 685094 317780 89623708
Troponin increased 69.94 14.16 9 686950 13272 89928216
Mood swings 69.42 14.16 35 686924 20667 89920821
Therapeutic response shortened 69.09 14.16 44 686915 22835 89918653
Ocular hyperaemia 68.97 14.16 93 686866 33705 89907783
Heart rate decreased 68.97 14.16 664 686295 52841 89888647
Panic attack 68.88 14.16 59 686900 26306 89915182
Posterior reversible encephalopathy syndrome 68.79 14.16 42 686917 22297 89919191
Muscle spasms 68.44 14.16 1422 685537 250461 89691027
Hepatocellular injury 68.38 14.16 71 686888 28887 89912601
Nephropathy toxic 68.29 14.16 8 686951 12680 89928808
Premature labour 68.23 14.16 10 686949 13366 89928122
Drug eruption 68.06 14.16 481 686478 34926 89906562
Lymphadenopathy 67.91 14.16 154 686805 45621 89895867
Abdominal distension 67.86 14.16 647 686312 129954 89811534
Rheumatoid lung 67.80 14.16 116 686843 3987 89937501
Paranoia 67.37 14.16 9 686950 12899 89928589
Poor quality sleep 67.31 14.16 53 686906 24640 89916848
Thirst 67.11 14.16 20 686939 16275 89925213
Infusion site swelling 66.67 14.16 6 686953 11714 89929774
Surgical failure 66.63 14.16 57 686902 922 89940566
Lacrimation increased 66.60 14.16 64 686895 26998 89914490
Complication associated with device 66.55 14.16 32 686927 19417 89922071
Transplant rejection 66.34 14.16 9 686950 12749 89928739
Renal tubular necrosis 65.40 14.16 15 686944 14540 89926948
Urine output decreased 65.28 14.16 9 686950 12594 89928894
Dermatitis contact 65.25 14.16 12 686947 13583 89927905
Fatigue 65.25 14.16 9830 677129 1144193 88797295
Ileus 65.13 14.16 22 686937 16524 89924964
Ventricular extrasystoles 65.11 14.16 11 686948 13239 89928249
Renal injury 64.89 14.16 3 686956 10240 89931248
Weight decreased 64.78 14.16 2292 684667 377618 89563870
Red blood cell count decreased 64.73 14.16 161 686798 46190 89895298
Apathy 64.60 14.16 5 686954 11035 89930453
Maternal exposure timing unspecified 64.58 14.16 339 686620 22144 89919344
Escherichia infection 64.58 14.16 20 686939 15875 89925613
Oliguria 64.52 14.16 4 686955 10620 89930868
Hyperthyroidism 64.39 14.16 29 686930 18281 89923207
Impaired quality of life 63.95 14.16 49 686910 23095 89918393
Metastases to lymph nodes 63.84 14.16 7 686952 11682 89929806
Stress cardiomyopathy 63.65 14.16 12 686947 13343 89928145
Eructation 63.47 14.16 5 686954 10877 89930611
Live birth 63.15 14.16 895 686064 78212 89863276
Malaise 62.84 14.16 3718 683241 582268 89359220
Haemorrhoids 62.45 14.16 66 686893 26636 89914852
Hepatic encephalopathy 62.27 14.16 14 686945 13758 89927730
Supraventricular tachycardia 62.12 14.16 23 686936 16313 89925175
Eye irritation 62.02 14.16 101 686858 33877 89907611
Product preparation error 61.91 14.16 4 686955 10257 89931231
Loss of consciousness 61.80 14.16 722 686237 139516 89801972
Atrioventricular block complete 61.74 14.16 3 686956 9808 89931680
Prothrombin time prolonged 61.46 14.16 3 686956 9769 89931719
Drug level decreased 61.15 14.16 3 686956 9727 89931761
Device malfunction 61.10 14.16 42 686917 20935 89920553
Cardiac failure acute 60.66 14.16 9 686950 11920 89929568
Respiratory syncytial virus infection 60.61 14.16 5 686954 10475 89931013
Adjustment disorder 60.51 14.16 3 686956 9639 89931849
Jaundice cholestatic 60.35 14.16 4 686955 10039 89931449
Short stature 60.32 14.16 56 686903 1014 89940474
Complication of device insertion 60.30 14.16 5 686954 10431 89931057
Throat tightness 60.30 14.16 81 686878 29403 89912085
Demyelination 60.00 14.16 166 686793 7974 89933514
Systemic lupus erythematosus rash 59.96 14.16 82 686877 2307 89939181
Atrial flutter 59.89 14.16 6 686953 10752 89930736
Joint arthroplasty 59.71 14.16 100 686859 3377 89938111
Injection site rash 59.68 14.16 57 686902 24116 89917372
Hypovolaemia 59.61 14.16 11 686948 12420 89929068
Seronegative arthritis 59.48 14.16 285 686674 17949 89923539
Drug resistance 58.94 14.16 87 686872 30362 89911126
Gastrooesophageal reflux disease 58.87 14.16 896 686063 165441 89776047
Insurance issue 58.75 14.16 7 686952 10951 89930537
Influenza 58.68 14.16 724 686235 138540 89802948
Polyneuropathy 58.67 14.16 37 686922 19304 89922184
Myocardial ischaemia 58.66 14.16 16 686943 13798 89927690
Myopathy 58.65 14.16 15 686944 13503 89927985
Spinal column injury 58.45 14.16 77 686882 2088 89939400
Initial insomnia 58.10 14.16 3 686956 9307 89932181
Cellulitis 58.06 14.16 429 686530 90908 89850580
Sputum discoloured 57.85 14.16 42 686917 20349 89921139
Hypoaesthesia oral 57.60 14.16 23 686936 15577 89925911
Red cell distribution width decreased 57.59 14.16 77 686882 2119 89939369
Purpura 57.56 14.16 20 686939 14758 89926730
Lupus-like syndrome 57.55 14.16 595 686364 48251 89893237
Polyuria 57.49 14.16 5 686954 10035 89931453
Infusion site reaction 57.42 14.16 291 686668 18748 89922740
Bone density decreased 57.23 14.16 272 686687 17073 89924415
Device leakage 57.15 14.16 5 686954 9986 89931502
Generalised oedema 57.04 14.16 37 686922 19016 89922472
Skin plaque 57.03 14.16 5 686954 9970 89931518
Laryngitis 56.87 14.16 612 686347 50141 89891347
Middle insomnia 56.65 14.16 28 686931 16723 89924765
Salivary hypersecretion 56.52 14.16 3 686956 9089 89932399
Vascular device infection 56.41 14.16 11 686948 11941 89929547
Vascular access complication 56.35 14.16 80 686879 2333 89939155
Arthrodesis 56.29 14.16 90 686869 2922 89938566
Feeling hot 56.24 14.16 353 686606 77655 89863833
Anger 56.21 14.16 17 686942 13703 89927785
Anosmia 56.13 14.16 5 686954 9843 89931645
Eyelid ptosis 55.89 14.16 3 686956 9003 89932485
Body temperature decreased 55.79 14.16 340 686619 23476 89918012
Device related infection 55.67 14.16 68 686891 25718 89915770
Blood pressure fluctuation 55.51 14.16 625 686334 51788 89889700
Restless legs syndrome 55.46 14.16 53 686906 22417 89919071
Therapy cessation 55.02 14.16 121 686838 36240 89905248
Neurologic neglect syndrome 54.74 14.16 3 686956 8844 89932644
Progressive multifocal leukoencephalopathy 54.74 14.16 25 686934 15630 89925858
Confusional state 54.72 14.16 3510 683449 382695 89558793
Loose body in joint 54.49 14.16 60 686899 1342 89940146
Shock haemorrhagic 54.27 14.16 13 686946 12232 89929256
Abortion induced 53.92 14.16 12 686947 11876 89929612
Paraesthesia 53.92 14.16 1464 685495 248862 89692626
Chromaturia 53.81 14.16 40 686919 19147 89922341
Extra dose administered 53.72 14.16 4 686955 9114 89932374
Thrombotic microangiopathy 53.72 14.16 26 686933 15717 89925771
Disability 53.68 14.16 508 686451 40237 89901251
Mean platelet volume decreased 53.56 14.16 87 686872 2863 89938625
Cholecystitis chronic 53.37 14.16 6 686953 9820 89931668
Nodule 53.33 14.16 366 686593 26320 89915168
Paralysis 53.26 14.16 11 686948 11467 89930021
Tumour lysis syndrome 53.19 14.16 10 686949 11142 89930346
Foetal growth restriction 52.83 14.16 5 686954 9375 89932113
Antibody test positive 52.72 14.16 87 686872 2902 89938586
Gangrene 52.67 14.16 16 686943 12860 89928628
Hip fracture 52.63 14.16 107 686852 32970 89908518
Hospice care 52.52 14.16 6 686953 9698 89931790
Heavy menstrual bleeding 52.35 14.16 47 686912 20483 89921005
Peripheral sensory neuropathy 51.91 14.16 5 686954 9245 89932243
Arterial occlusive disease 51.76 14.16 15 686944 12431 89929057
Osteonecrosis 51.75 14.16 74 686885 26167 89915321
Cold sweat 51.60 14.16 21 686938 14060 89927428
Gestational diabetes 51.53 14.16 9 686950 10573 89930915
Physical disability 51.20 14.16 101 686858 3880 89937608
Immune effector cell-associated neurotoxicity syndrome 51.09 14.16 126 686833 5642 89935846
Haemodialysis 51.07 14.16 4 686955 8743 89932745
Facial pain 51.07 14.16 18 686941 13164 89928324
Haemodynamic instability 50.98 14.16 13 686946 11726 89929762
Pneumonia viral 50.89 14.16 165 686794 8658 89932830
Acute respiratory distress syndrome 50.76 14.16 87 686872 28599 89912889
Ankle arthroplasty 50.74 14.16 83 686876 2748 89938740
Toxic encephalopathy 50.73 14.16 4 686955 8695 89932793
Dizziness postural 50.53 14.16 5 686954 9048 89932440
Aspiration 50.46 14.16 28 686931 15665 89925823
Central nervous system lesion 50.38 14.16 13 686946 11633 89929855
Feeling cold 49.80 14.16 82 686877 27383 89914105
Device breakage 49.77 14.16 22 686937 14022 89927466
Lymphopenia 49.76 14.16 60 686899 22821 89918667
Device occlusion 49.59 14.16 6 686953 9276 89932212
Haemolytic anaemia 48.83 14.16 14 686945 11683 89929805
Dry mouth 48.64 14.16 1779 685180 182280 89759208
Abdominal pain lower 48.54 14.16 97 686862 30080 89911408
Viral infection 48.15 14.16 157 686802 41257 89900231
Bacteraemia 47.94 14.16 59 686900 22241 89919247
Bundle branch block left 47.80 14.16 3 686956 7882 89933606
Pneumonitis 47.60 14.16 173 686786 43997 89897491
Electrocardiogram abnormal 47.51 14.16 10 686949 10288 89931200
Vitamin D deficiency 47.45 14.16 38 686921 17518 89923970
Breast cancer female 47.23 14.16 27 686932 14859 89926629
Rash maculo-papular 47.02 14.16 156 686803 40777 89900711
Acute pulmonary oedema 46.97 14.16 8 686951 9572 89931916
Body height decreased 46.84 14.16 16 686943 11933 89929555
Graft versus host disease 46.79 14.16 4 686955 8140 89933348
Brain injury 46.74 14.16 3 686956 7735 89933753
Hiatus hernia 46.65 14.16 75 686884 25286 89916202
Throat irritation 46.57 14.16 200 686759 48495 89892993
Atrioventricular block 46.36 14.16 6 686953 8809 89932679
Second primary malignancy 46.03 14.16 11 686948 10367 89931121
Feeding disorder 45.98 14.16 39 686920 17473 89924015
Joint effusion 45.93 14.16 281 686678 19429 89922059
Proteinuria 45.62 14.16 66 686893 23225 89918263
Hepatic cirrhosis 45.54 14.16 703 686256 62550 89878938
Respiration abnormal 45.51 14.16 4 686955 7959 89933529
Arteriosclerosis 45.28 14.16 13 686946 10840 89930648
Lipase increased 45.10 14.16 14 686945 11097 89930391
Pre-eclampsia 44.71 14.16 14 686945 11034 89930454
Nephropathy 44.65 14.16 8 686951 9227 89932261
Proctalgia 44.54 14.16 5 686954 8193 89933295
Nervous system disorder 44.48 14.16 59 686900 21534 89919954
Congestive cardiomyopathy 43.98 14.16 3 686956 7351 89934137
Candida infection 43.98 14.16 123 686836 33934 89907554
Escherichia urinary tract infection 43.91 14.16 25 686934 13790 89927698
Myocarditis 43.86 14.16 25 686934 13781 89927707
Diastolic dysfunction 43.83 14.16 3 686956 7330 89934158
Personality change 43.74 14.16 3 686956 7318 89934170
Neuralgia 43.53 14.16 110 686849 31390 89910098
Partial seizures 43.31 14.16 3 686956 7257 89934231
Genital haemorrhage 43.26 14.16 7 686952 8695 89932793
Pulmonary haemorrhage 43.26 14.16 5 686954 8008 89933480
Stress 43.23 14.16 401 686558 80994 89860494
Anticipatory anxiety 43.20 14.16 50 686909 1183 89940305
Rales 43.10 14.16 34 686925 15793 89925695
Nystagmus 43.07 14.16 3 686956 7224 89934264
Hypocalcaemia 43.03 14.16 170 686789 42198 89899290
Product prescribing issue 43.02 14.16 5 686954 7974 89933514
Bipolar disorder 42.98 14.16 8 686951 8977 89932511
Therapy change 42.97 14.16 6 686953 8316 89933172
Glycosylated haemoglobin increased 42.93 14.16 33 686926 15529 89925959
Eyelid oedema 42.59 14.16 17 686942 11517 89929971
Eosinophil count increased 42.55 14.16 23 686936 13058 89928430
Choking 42.41 14.16 19 686940 12014 89929474
Tension headache 42.30 14.16 4 686955 7505 89933983
Flank pain 42.23 14.16 50 686909 19172 89922316
Walking aid user 42.06 14.16 433 686526 35073 89906415
Blood thyroid stimulating hormone increased 42.01 14.16 9 686950 9146 89932342
Hyperthermia 41.99 14.16 13 686946 10322 89931166
Amylase increased 41.96 14.16 3 686956 7069 89934419
Activated partial thromboplastin time prolonged 41.95 14.16 5 686954 7820 89933668
Stillbirth 41.83 14.16 4 686955 7439 89934049
Hyperbilirubinaemia 41.81 14.16 27 686932 13909 89927579
Multiple fractures 41.59 14.16 163 686796 9399 89932089
Odynophagia 41.28 14.16 9 686950 9034 89932454
Bronchospasm 41.23 14.16 58 686901 20651 89920837
Blood creatine increased 41.21 14.16 3 686956 6964 89934524
Arteriosclerosis coronary artery 41.01 14.16 11 686948 9592 89931896
Head discomfort 40.93 14.16 38 686921 16295 89925193
Mesenteritis 40.85 14.16 28 686931 319 89941169
Faecaloma 40.83 14.16 14 686945 10417 89931071
Juvenile idiopathic arthritis 40.80 14.16 92 686867 3885 89937603
Cytomegalovirus infection 40.69 14.16 88 686871 26514 89914974
Diverticular perforation 40.66 14.16 89 686870 3683 89937805
Product use in unapproved indication 40.64 14.16 2108 684851 334128 89607360
Diabetes mellitus inadequate control 40.62 14.16 49 686910 18635 89922853
Needle issue 40.45 14.16 28 686931 13906 89927582
Osteoporotic fracture 40.42 14.16 102 686857 4634 89936854
Blood glucose abnormal 40.29 14.16 11 686948 9481 89932007
Orthopnoea 40.26 14.16 3 686956 6832 89934656
Growth failure 40.24 14.16 29 686930 360 89941128
Miosis 40.24 14.16 11 686948 9473 89932015
Abnormal loss of weight 40.18 14.16 3 686956 6820 89934668
Cataract 40.11 14.16 351 686608 71741 89869747
Major depression 40.10 14.16 13 686946 10022 89931466
Atrial septal defect 40.10 14.16 7 686952 8227 89933261
Uterine perforation 40.07 14.16 5 686954 7549 89933939
Skin irritation 39.94 14.16 27 686932 13576 89927912
Pyrexia 39.89 14.16 4390 682569 656095 89285393
Frequent bowel movements 39.84 14.16 260 686699 56675 89884813
Gastrointestinal perforation 39.83 14.16 96 686863 4236 89937252
Bacterial infection 39.77 14.16 73 686886 23371 89918117
Fistula 39.70 14.16 21 686938 12068 89929420
Hereditary angioedema 39.48 14.16 11 686948 9354 89932134
Ischaemic stroke 39.43 14.16 67 686892 22099 89919389
Hypovolaemic shock 39.38 14.16 4 686955 7090 89934398
Erythema multiforme 39.16 14.16 22 686937 12224 89929264
Wheelchair user 39.11 14.16 139 686820 7646 89933842
Gout 39.06 14.16 42 686917 16817 89924671
Retinal toxicity 39.05 14.16 51 686908 1371 89940117
Product availability issue 39.03 14.16 5 686954 7399 89934089
Amenorrhoea 39.03 14.16 20 686939 11702 89929786
Cerebral infarction 39.02 14.16 90 686869 26506 89914982
Blood urine present 38.98 14.16 44 686915 17234 89924254
Heart rate increased 38.97 14.16 611 686348 112291 89829197
Presbyacusis 38.91 14.16 77 686882 2965 89938523
Gallbladder disorder 38.90 14.16 56 686903 19747 89921741
Limb mass 38.89 14.16 84 686875 3444 89938044
Neck pain 38.75 14.16 1135 685824 112828 89828660
Pulseless electrical activity 38.58 14.16 10 686949 8922 89932566
Hypoaesthesia 38.54 14.16 2822 684137 311388 89630100
Hepatomegaly 38.39 14.16 27 686932 13299 89928189
Pancreatitis 38.39 14.16 341 686618 69485 89872003
Cardiac murmur 38.21 14.16 49 686910 18145 89923343
Expired product administered 38.17 14.16 4 686955 6918 89934570
Pseudomonas infection 37.94 14.16 34 686925 14831 89926657
Exercise tolerance decreased 37.71 14.16 6 686953 7545 89933943
Intentional product misuse 37.68 14.16 466 686493 89138 89852350
Exposure via skin contact 37.58 14.16 17 686942 10688 89930800
Splenomegaly 37.48 14.16 26 686933 12898 89928590
Metabolic disorder 37.16 14.16 6 686953 7464 89934024
Blood iron decreased 37.07 14.16 49 686910 17910 89923578
Toothache 37.06 14.16 292 686667 21938 89919550
Skin disorder 36.82 14.16 148 686811 36558 89904930
Hyperventilation 36.82 14.16 4 686955 6724 89934764
Musculoskeletal chest pain 36.79 14.16 78 686881 23672 89917816
Carotid artery occlusion 36.75 14.16 3 686956 6339 89935149
Petechiae 36.71 14.16 39 686920 15702 89925786
Lower gastrointestinal haemorrhage 36.46 14.16 11 686948 8881 89932607
Mean cell volume decreased 36.34 14.16 95 686864 4411 89937077
Defaecation urgency 36.04 14.16 3 686956 6239 89935249
Rib fracture 36.00 14.16 93 686866 26342 89915146
Adverse drug reaction 35.87 14.16 1148 685811 115553 89825935
Blood loss anaemia 35.75 14.16 16 686943 10124 89931364
Photosensitivity reaction 35.33 14.16 50 686909 17757 89923731
Acute coronary syndrome 35.19 14.16 19 686940 10794 89930694
Pain in jaw 35.18 14.16 216 686743 47769 89893719
Acidosis 35.14 14.16 27 686932 12709 89928779
Peptic ulcer haemorrhage 35.13 14.16 43 686916 1081 89940407
Pruritus allergic 35.12 14.16 54 686905 1694 89939794
Angina unstable 34.95 14.16 6 686953 7137 89934351
Squamous cell carcinoma of skin 34.85 14.16 7 686952 7442 89934046
Feeling jittery 34.83 14.16 39 686920 15332 89926156
Subarachnoid haemorrhage 34.80 14.16 51 686908 17853 89923635
Asphyxia 34.68 14.16 6 686953 7097 89934391
Metabolic encephalopathy 34.55 14.16 5 686954 6747 89934741
Injection site irritation 34.43 14.16 3 686956 6012 89935476
Hypernatraemia 34.40 14.16 14 686945 9373 89932115
Post procedural complication 34.38 14.16 57 686902 18985 89922503
Hepatitis cholestatic 34.37 14.16 11 686948 8550 89932938
Aortic arteriosclerosis 34.37 14.16 8 686951 7676 89933812
Hypofibrinogenaemia 34.35 14.16 47 686912 1323 89940165
Coronary artery occlusion 34.33 14.16 11 686948 8543 89932945
Pharyngitis 34.26 14.16 284 686675 21663 89919825
Bedridden 34.09 14.16 182 686777 11966 89929522
Adverse reaction 34.09 14.16 360 686599 29352 89912136
Gastric ulcer 34.07 14.16 101 686858 27347 89914141
Peripheral coldness 34.01 14.16 33 686926 13859 89927629
Autoimmune hepatitis 33.96 14.16 18 686941 10333 89931155
Decreased activity 33.84 14.16 10 686949 8182 89933306
Infusion site extravasation 33.83 14.16 18 686941 10310 89931178
Upper-airway cough syndrome 33.65 14.16 39 686920 15096 89926392
Post transplant lymphoproliferative disorder 33.64 14.16 6 686953 6943 89934545
Injection site reaction 33.51 14.16 925 686034 91155 89850333
Thinking abnormal 33.50 14.16 24 686935 11708 89929780
Impaired work ability 33.40 14.16 256 686703 19070 89922418
Intermenstrual bleeding 33.40 14.16 14 686945 9209 89932279
Embolism 33.37 14.16 15 686944 9466 89932022
Colitis microscopic 33.26 14.16 170 686789 10989 89930499
Injection site induration 33.19 14.16 19 686940 10449 89931039
Cerebral ischaemia 33.18 14.16 7 686952 7189 89934299
Cachexia 33.16 14.16 6 686953 6872 89934616
Blood disorder 33.12 14.16 9 686950 7781 89933707
Burning sensation 33.10 14.16 314 686645 63138 89878350
Herpes simplex 32.97 14.16 18 686941 10163 89931325
Emotional disorder 32.96 14.16 39 686920 14958 89926530
Sensory disturbance 32.90 14.16 41 686918 15372 89926116
Fine motor skill dysfunction 32.77 14.16 103 686856 5316 89936172
Transaminases abnormal 32.76 14.16 34 686925 709 89940779
Gastric haemorrhage 32.56 14.16 7 686952 7096 89934392
Incorrect dose administered by device 32.47 14.16 3 686956 5734 89935754
Pleural fibrosis 32.33 14.16 79 686880 3517 89937971
Retching 32.19 14.16 60 686899 19099 89922389
Soft tissue disorder 32.13 14.16 88 686871 4202 89937286
Nephrotic syndrome 32.12 14.16 8 686951 7331 89934157
Blindness 32.09 14.16 99 686860 26469 89915019
Hepatic lesion 32.01 14.16 3 686956 5670 89935818
Product physical issue 31.92 14.16 3 686956 5657 89935831
Extrasystoles 31.90 14.16 3 686956 5654 89935834
Perineal rash 31.88 14.16 15 686944 76 89941412
Dermatitis acneiform 31.84 14.16 5 686954 6349 89935139
Headache 31.82 14.16 5908 681051 856838 89084650
Autoimmune haemolytic anaemia 31.82 14.16 3 686956 5642 89935846
Tooth loss 31.61 14.16 9 686950 7545 89933943
Growth retardation 31.58 14.16 52 686907 1731 89939757
Essential hypertension 31.57 14.16 5 686954 6310 89935178
Affective disorder 31.31 14.16 10 686949 7783 89933705
Device failure 31.21 14.16 7 686952 6890 89934598
Respiratory tract congestion 31.12 14.16 105 686854 27305 89914183
Immune thrombocytopenia 31.10 14.16 33 686926 13293 89928195
Skin hyperpigmentation 30.90 14.16 7 686952 6844 89934644
Skin fissures 30.87 14.16 70 686889 20739 89920749
Torus fracture 30.85 14.16 18 686941 151 89941337
Infiltration anaesthesia 30.82 14.16 19 686940 178 89941310
Oesophageal candidiasis 30.76 14.16 7 686952 6822 89934666
Micturition urgency 30.76 14.16 24 686935 11209 89930279
Gastrointestinal procedural complication 30.66 14.16 27 686932 455 89941033
Mean cell haemoglobin decreased 30.62 14.16 104 686855 5591 89935897
Pelvic pain 30.59 14.16 43 686916 15314 89926174
Periorbital oedema 30.56 14.16 7 686952 6792 89934696
Protein total decreased 30.50 14.16 8 686951 7081 89934407
Tongue oedema 30.47 14.16 3 686956 5451 89936037
Drug effect less than expected 30.37 14.16 5 686954 6133 89935355
Parosmia 30.37 14.16 8 686951 7061 89934427
Infusion site pruritus 30.34 14.16 7 686952 6758 89934730
Nail operation 30.34 14.16 53 686906 1853 89939635
Low birth weight baby 30.28 14.16 17 686942 9450 89932038
Ear discomfort 30.28 14.16 20 686939 10180 89931308
Atypical femur fracture 30.11 14.16 6 686953 6415 89935073
Gastrointestinal motility disorder 30.06 14.16 5 686954 6086 89935402
Lymphoedema 29.97 14.16 36 686923 13717 89927771
Breast cancer stage II 29.91 14.16 404 686555 34930 89906558
Alanine aminotransferase increased 29.82 14.16 676 686283 117662 89823826
Abnormal faeces 29.80 14.16 7 686952 6675 89934813
Ulcer haemorrhage 29.77 14.16 318 686641 26003 89915485
Azotaemia 29.73 14.16 3 686956 5345 89936143
Skin lesion 29.63 14.16 164 686795 37201 89904287
Spinal osteoarthritis 29.57 14.16 63 686896 19085 89922403
Heparin-induced thrombocytopenia 29.48 14.16 3 686956 5309 89936179
Mouth swelling 29.43 14.16 4 686955 5658 89935830
Deafness 29.30 14.16 81 686878 22433 89919055
Spondylitis 29.25 14.16 196 686763 13982 89927506
Enterocolitis 29.25 14.16 22 686937 10468 89931020
Rhinovirus infection 29.19 14.16 5 686954 5958 89935530
Pemphigoid 29.17 14.16 16 686943 9010 89932478
Abdominal pain upper 29.17 14.16 2914 684045 329760 89611728
Sarcoidosis 28.98 14.16 23 686936 10650 89930838
Vasculitic rash 28.95 14.16 44 686915 1366 89940122
Lumbosacral plexopathy 28.93 14.16 15 686944 97 89941391
Wrong product administered 28.80 14.16 11 686948 7654 89933834
Jaw disorder 28.72 14.16 4 686955 5555 89935933
Cholecystectomy 28.69 14.16 28 686931 11727 89929761
Localised oedema 28.61 14.16 6 686953 6188 89935300
Crying 28.60 14.16 99 686860 25546 89915942
Impaired driving ability 28.50 14.16 3 686956 5170 89936318
Hyperammonaemia 28.45 14.16 7 686952 6468 89935020
Large intestine polyp 28.41 14.16 18 686941 9368 89932120
Cutaneous vasculitis 28.41 14.16 119 686840 7074 89934414
Rebound effect 28.40 14.16 18 686941 9366 89932122
Breast cancer recurrent 28.34 14.16 4 686955 5499 89935989
Enteritis 28.33 14.16 22 686937 10299 89931189
Iron deficiency 28.32 14.16 19 686940 9593 89931895
Dermatitis bullous 28.30 14.16 22 686937 10294 89931194
Lung neoplasm malignant 28.23 14.16 92 686867 24181 89917307
Neutrophil count increased 28.14 14.16 66 686893 19324 89922164
Aspartate aminotransferase increased 27.97 14.16 581 686378 102356 89839132
Drug specific antibody 27.91 14.16 60 686899 2452 89939036
Post procedural haemorrhage 27.85 14.16 16 686943 8782 89932706
Refusal of treatment by patient 27.68 14.16 5 686954 5733 89935755
Oropharyngeal pain 27.63 14.16 663 686296 114524 89826964
Renal function test abnormal 27.55 14.16 10 686949 7181 89934307
Aortic stenosis 27.55 14.16 7 686952 6329 89935159
Lower respiratory tract congestion 27.32 14.16 71 686888 3285 89938203
Apnoea 27.22 14.16 19 686940 9395 89932093
Urosepsis 27.18 14.16 77 686882 21155 89920333
Vitamin B12 decreased 27.02 14.16 4 686955 5306 89936182
Pigmentation disorder 26.99 14.16 6 686953 5943 89935545
Cardiac tamponade 26.97 14.16 5 686954 5627 89935861
Intracranial pressure increased 26.91 14.16 9 686950 6802 89934686
Pleural thickening 26.73 14.16 69 686890 3179 89938309
Varicose vein 26.73 14.16 11 686948 7316 89934172
Haemorrhagic stroke 26.70 14.16 8 686951 6488 89935000
Hysterectomy 26.68 14.16 29 686930 11555 89929933
Sudden death 26.61 14.16 26 686933 10883 89930605
Menstruation irregular 26.47 14.16 14 686945 8046 89933442
Kidney transplant rejection 26.30 14.16 3 686956 4854 89936634
Aplasia pure red cell 26.22 14.16 4 686955 5190 89936298
Heart rate irregular 26.18 14.16 95 686864 24173 89917315
Surgery 26.11 14.16 216 686743 44671 89896817
Blood potassium increased 26.01 14.16 76 686883 20673 89920815
Ocular discomfort 25.90 14.16 8 686951 6362 89935126
Injection site haematoma 25.89 14.16 10 686949 6912 89934576
Gastrointestinal infection 25.89 14.16 27 686932 10963 89930525
Sensation of foreign body 25.88 14.16 8 686951 6358 89935130
Acute graft versus host disease 25.87 14.16 5 686954 5463 89936025
Peroneal nerve palsy 25.68 14.16 6 686953 5742 89935746
Porphyria acute 25.64 14.16 228 686731 17747 89923741
Eye injury 25.61 14.16 157 686802 10863 89930625
Onychoclasis 25.58 14.16 12 686947 7387 89934101
Glaucoma 25.49 14.16 255 686704 20500 89920988
Ventricular septal defect 25.47 14.16 5 686954 5402 89936086
Application site pain 25.34 14.16 3 686956 4717 89936771
Cystitis 25.11 14.16 355 686604 66363 89875125
Product administered to patient of inappropriate age 24.88 14.16 3 686956 4650 89936838
Sinus headache 24.82 14.16 9 686950 6467 89935021
Clostridial infection 24.76 14.16 3 686956 4633 89936855
Papule 24.70 14.16 15 686944 7987 89933501
Extremity contracture 24.66 14.16 39 686920 1254 89940234
Protein urine present 24.66 14.16 11 686948 6973 89934515
Intentional dose omission 24.65 14.16 62 686897 17721 89923767
Premature rupture of membranes 24.44 14.16 6 686953 5552 89935936
Blood uric acid increased 24.40 14.16 14 686945 7690 89933798
Increased appetite 24.38 14.16 32 686927 11733 89929755
Dermatitis exfoliative 24.29 14.16 6 686953 5530 89935958
Prosthesis user 24.29 14.16 12 686947 69 89941419
Failure to thrive 24.29 14.16 17 686942 8394 89933094
Concussion 24.21 14.16 29 686930 11062 89930426
Tooth extraction 24.19 14.16 31 686928 11482 89930006
Enterococcal infection 24.15 14.16 24 686935 9967 89931521
Blindness transient 24.12 14.16 3 686956 4540 89936948
Synovial cyst 23.97 14.16 162 686797 11590 89929898
Pathogen resistance 23.97 14.16 16 686943 8099 89933389
Transaminases increased 23.96 14.16 174 686785 37018 89904470
Crohn's disease 23.90 14.16 4 686955 4847 89936641
Lung consolidation 23.82 14.16 4 686955 4836 89936652
Escherichia bacteraemia 23.69 14.16 7 686952 5728 89935760
Sleep terror 23.57 14.16 3 686956 4461 89937027
Pulmonary alveolar haemorrhage 23.57 14.16 8 686951 5990 89935498
Haemolysis 23.53 14.16 18 686941 8492 89932996
Blood folate decreased 23.48 14.16 44 686915 1626 89939862
Normochromic normocytic anaemia 23.45 14.16 5 686954 5097 89936391
Product storage error 23.35 14.16 77 686882 20164 89921324
Glucose tolerance impaired 23.24 14.16 16 686943 7969 89933519
Hepatitis C 23.21 14.16 7 686952 5653 89935835
Blood triglycerides increased 23.21 14.16 43 686916 13718 89927770
Overweight 23.17 14.16 8 686951 5926 89935562
Euglycaemic diabetic ketoacidosis 23.13 14.16 9 686950 6192 89935296
Cerebral atrophy 23.12 14.16 7 686952 5639 89935849
Muscle atrophy 22.94 14.16 18 686941 8383 89933105
Photopsia 22.93 14.16 5 686954 5019 89936469
Skin papilloma 22.91 14.16 94 686865 5536 89935952
Portal hypertension 22.89 14.16 4 686955 4697 89936791
Skin mass 22.83 14.16 14 686945 7416 89934072
Left ventricular hypertrophy 22.78 14.16 9 686950 6135 89935353
Ovarian cyst 22.77 14.16 62 686897 17256 89924232
Immunosuppressant drug level increased 22.75 14.16 4 686955 4676 89936812
Dysmenorrhoea 22.69 14.16 4 686955 4668 89936820
Colitis ulcerative 22.57 14.16 321 686638 59945 89881543
Lip oedema 22.47 14.16 4 686955 4635 89936853
Cardiac flutter 22.46 14.16 4 686955 4634 89936854
Anal fistula 22.45 14.16 3 686956 4298 89937190
Necrosis 22.43 14.16 11 686948 6599 89934889
Klebsiella infection 22.39 14.16 27 686932 10270 89931218
Allergy to chemicals 22.38 14.16 71 686888 3683 89937805
Neurological symptom 22.33 14.16 12 686947 6835 89934653
Pulse absent 22.24 14.16 9 686950 6046 89935442
Retinal haemorrhage 22.11 14.16 8 686951 5756 89935732
Multiple-drug resistance 22.08 14.16 16 686943 7760 89933728
Peptic ulcer 22.04 14.16 7 686952 5468 89936020
Drug dependence 22.03 14.16 131 686828 29196 89912292
Intestinal sepsis 22.03 14.16 19 686940 311 89941177
Bone swelling 22.01 14.16 44 686915 1707 89939781
Peritonitis bacterial 21.94 14.16 6 686953 5165 89936323
Bundle branch block right 21.90 14.16 7 686952 5446 89936042
Immune reconstitution inflammatory syndrome 21.89 14.16 13 686946 7006 89934482
Oropharyngeal discomfort 21.85 14.16 16 686943 7719 89933769
Injection site discolouration 21.84 14.16 23 686936 9297 89932191
Hypertonia 21.83 14.16 6 686953 5149 89936339
Brachiocephalic artery stenosis 21.82 14.16 9 686950 31 89941457
Thrombocytosis 21.78 14.16 13 686946 6988 89934500
Blood magnesium increased 21.74 14.16 66 686893 3342 89938146
Lupus nephritis 21.67 14.16 5 686954 4827 89936661
Epidural lipomatosis 21.66 14.16 17 686942 242 89941246
Metastatic neoplasm 21.56 14.16 5 686954 4810 89936678
Left ventricular failure 21.47 14.16 12 686947 6688 89934800
Skin tightness 21.46 14.16 4 686955 4484 89937004
Catheter site infection 21.43 14.16 8 686951 5646 89935842
Ileus paralytic 21.39 14.16 6 686953 5079 89936409
Cardiac failure chronic 21.38 14.16 8 686951 5638 89935850
Renal cyst 21.37 14.16 41 686918 12909 89928579
Colitis ischaemic 21.34 14.16 38 686921 12308 89929180
Viral upper respiratory tract infection 21.34 14.16 125 686834 8509 89932979
Thrombotic thrombocytopenic purpura 21.33 14.16 3 686956 4135 89937353
Hypertensive cardiomyopathy 21.31 14.16 18 686941 286 89941202
Trigeminal neuralgia 21.28 14.16 3 686956 4128 89937360
Wound complication 21.22 14.16 5 686954 4758 89936730
Diarrhoea haemorrhagic 21.09 14.16 30 686929 10633 89930855
Hypopnoea 21.08 14.16 4 686955 4427 89937061
Psychiatric symptom 21.07 14.16 14 686945 7104 89934384
Laryngeal pain 21.02 14.16 4 686955 4418 89937070
Pulmonary congestion 21.01 14.16 76 686883 19357 89922131
Vascular stenosis 20.94 14.16 23 686936 513 89940975
Rotator cuff syndrome 20.92 14.16 57 686902 15862 89925626
Gastrointestinal toxicity 20.83 14.16 133 686826 9334 89932154
Vascular rupture 20.62 14.16 44 686915 1789 89939699
Urine abnormality 20.60 14.16 17 686942 7720 89933768
Cystitis haemorrhagic 20.56 14.16 8 686951 5505 89935983
Arthritis bacterial 20.52 14.16 111 686848 7334 89934154
Thyroid cancer 20.51 14.16 11 686948 6273 89935215
Platelet count abnormal 20.44 14.16 4 686955 4331 89937157
SARS-CoV-2 test positive 20.38 14.16 33 686926 11095 89930393
Aphonia 20.33 14.16 39 686920 12280 89929208
Sleep disorder due to a general medical condition 20.21 14.16 229 686730 44509 89896979
Hepatitis acute 20.21 14.16 32 686927 10855 89930633
Diverticulitis intestinal perforated 20.18 14.16 20 686939 394 89941094
Hyperuricaemia 20.18 14.16 13 686946 6706 89934782
Facial paralysis 20.13 14.16 56 686903 15478 89926010
Cerebral haematoma 20.13 14.16 4 686955 4285 89937203
Breast cancer stage I 20.13 14.16 26 686933 9598 89931890
Femoral neck fracture 20.04 14.16 29 686930 10204 89931284
Interleukin level increased 19.99 14.16 26 686933 696 89940792
Neoscytalidium infection 19.98 14.16 7 686952 13 89941475
Injection site discomfort 19.98 14.16 10 686949 5930 89935558
Diabetic eye disease 19.96 14.16 14 686945 166 89941322
Patent ductus arteriosus 19.96 14.16 5 686954 4564 89936924
Pharyngeal abscess 19.94 14.16 20 686939 400 89941088
Temperature intolerance 19.93 14.16 38 686921 11992 89929496
Hydronephrosis 19.83 14.16 40 686919 12362 89929126
Gastrointestinal pain 19.81 14.16 34 686925 11172 89930316
Polycystic ovaries 19.81 14.16 9 686950 5645 89935843
Anal fissure 19.78 14.16 8 686951 5377 89936111
Haemoglobin abnormal 19.66 14.16 15 686944 7085 89934403
Hypertensive crisis 19.60 14.16 69 686890 17715 89923773
Device related sepsis 19.53 14.16 6 686953 4787 89936701
Lung opacity 19.46 14.16 11 686948 6091 89935397
Dermatitis exfoliative generalised 19.45 14.16 9 686950 5584 89935904
Vulvovaginal mycotic infection 19.26 14.16 12 686947 6302 89935186
Ischaemia 19.23 14.16 8 686951 5287 89936201
Neutropenic colitis 19.16 14.16 4 686955 4139 89937349
Bacterial test positive 19.13 14.16 9 686950 5530 89935958
Cheilitis 19.12 14.16 7 686952 5000 89936488
Hypercalcaemia 19.01 14.16 365 686594 33875 89907613
Rheumatic disorder 19.00 14.16 63 686896 3345 89938143
Cardiac pacemaker insertion 18.91 14.16 5 686954 4402 89937086
Spinal operation 18.90 14.16 30 686929 10166 89931322
Circumstance or information capable of leading to medication error 18.87 14.16 7 686952 4960 89936528
Blood thyroid stimulating hormone decreased 18.81 14.16 10 686949 5730 89935758
Urine analysis abnormal 18.79 14.16 8 686951 5213 89936275
Hypoxic-ischaemic encephalopathy 18.74 14.16 6 686953 4662 89936826
Seasonal allergy 18.71 14.16 100 686859 22883 89918605
Oral mucosal blistering 18.70 14.16 15 686944 6909 89934579
Infusion site bruising 18.68 14.16 5 686954 4367 89937121
Diverticulum 18.58 14.16 40 686919 12073 89929415
Behaviour disorder 18.53 14.16 6 686953 4629 89936859
Dermatitis allergic 18.52 14.16 207 686752 17120 89924368
Squamous cell carcinoma 18.46 14.16 30 686929 10071 89931417
Atypical pneumonia 18.44 14.16 8 686951 5156 89936332
Epilepsy 18.29 14.16 780 686179 81426 89860062
Feeling of body temperature change 18.28 14.16 10 686949 5639 89935849
Uterine leiomyoma 18.27 14.16 34 686925 10830 89930658
Cholecystitis 18.19 14.16 67 686892 16973 89924515
Hair growth abnormal 18.18 14.16 3 686956 3673 89937815
Aplasia 18.16 14.16 4 686955 3987 89937501
Catheter site haemorrhage 18.12 14.16 3 686956 3665 89937823
Hydrocephalus 18.02 14.16 12 686947 6082 89935406
Facial paresis 17.98 14.16 4 686955 3959 89937529
Thyroiditis 17.92 14.16 3 686956 3634 89937854
Respiratory symptom 17.91 14.16 5 686954 4247 89937241
Disability assessment scale score decreased 17.91 14.16 6 686953 9 89941479
Blood culture positive 17.89 14.16 8 686951 5064 89936424
Meningitis aseptic 17.88 14.16 15 686944 6758 89934730
Cardiac operation 17.88 14.16 4 686955 3945 89937543
Nerve compression 17.83 14.16 33 686926 10533 89930955
Functional gastrointestinal disorder 17.83 14.16 8 686951 5054 89936434
Stridor 17.80 14.16 7 686952 4786 89936702
Muscle tightness 17.75 14.16 48 686911 13391 89928097
Intervertebral disc compression 17.75 14.16 33 686926 1212 89940276
Pustular psoriasis 17.75 14.16 217 686742 18339 89923149
Obstruction 17.70 14.16 4 686955 3917 89937571
Pulmonary function test decreased 17.65 14.16 6 686953 4488 89937000
Venous thrombosis 17.63 14.16 10 686949 5527 89935961
Stent placement 17.60 14.16 5 686954 4198 89937290
Pneumothorax 17.55 14.16 80 686879 19087 89922401
Incorrect product administration duration 17.49 14.16 81 686878 19241 89922247
Laboratory test abnormal 17.47 14.16 218 686741 41636 89899852
Intercepted product storage error 17.35 14.16 20 686939 471 89941017
Granulocytopenia 17.34 14.16 14 686945 6427 89935061
Wrist surgery 17.34 14.16 28 686931 917 89940571
Nocturia 17.33 14.16 32 686927 10223 89931265
Wrist deformity 17.29 14.16 59 686900 3179 89938309
Peripheral vascular disorder 17.28 14.16 14 686945 6417 89935071
Sluggishness 17.26 14.16 12 686947 5947 89935541
Breast pain 17.18 14.16 33 686926 10385 89931103
Neurolysis 17.12 14.16 5 686954 3 89941485
Neutrophil count abnormal 17.12 14.16 5 686954 4123 89937365
Clubbing 17.06 14.16 20 686939 480 89941008
Bone cyst 17.04 14.16 48 686911 2330 89939158
Leukopenia 17.03 14.16 608 686351 100102 89841386
Neurological decompensation 17.00 14.16 3 686956 3498 89937990
Inflammatory bowel disease 16.95 14.16 9 686950 5162 89936326
Menstrual disorder 16.95 14.16 13 686946 6125 89935363
Bunion operation 16.92 14.16 34 686925 1324 89940164
Subcutaneous drug absorption impaired 16.91 14.16 167 686792 13378 89928110
Muscle abscess 16.87 14.16 18 686941 388 89941100
White blood cell count abnormal 16.87 14.16 106 686853 7398 89934090
Bruxism 16.83 14.16 6 686953 4357 89937131
Lumbar vertebral fracture 16.82 14.16 19 686940 7439 89934049
Insomnia 16.79 14.16 2824 684135 330650 89610838
Papilloedema 16.72 14.16 7 686952 4608 89936880
Musculoskeletal discomfort 16.72 14.16 92 686867 20899 89920589
Somatic symptom disorder 16.60 14.16 3 686956 3438 89938050
Facial bones fracture 16.56 14.16 4 686955 3743 89937745
Pneumocystis jirovecii pneumonia 16.53 14.16 96 686863 21520 89919968
Vulvovaginal dryness 16.53 14.16 3 686956 3428 89938060
Androgenetic alopecia 16.51 14.16 13 686946 186 89941302
Distributive shock 16.48 14.16 3 686956 3421 89938067
Ear canal erythema 16.48 14.16 8 686951 44 89941444
Subdural haemorrhage 16.47 14.16 3 686956 3420 89938068
Blood glucose fluctuation 16.44 14.16 9 686950 5074 89936414
Brain death 16.44 14.16 5 686954 4016 89937472
Electrocardiogram ST segment elevation 16.41 14.16 5 686954 4011 89937477
Haemorrhoidal haemorrhage 16.40 14.16 10 686949 5313 89936175
Rheumatoid vasculitis 16.37 14.16 18 686941 402 89941086
Neutrophilia 16.26 14.16 12 686947 5766 89935722
Ventricular hypertrophy 16.26 14.16 3 686956 3388 89938100
Cholecystitis acute 16.20 14.16 29 686930 9375 89932113
Respiratory rate decreased 16.20 14.16 5 686954 3978 89937510
Skin erosion 16.20 14.16 3 686956 3379 89938109
Gastropleural fistula 16.19 14.16 8 686951 46 89941442
Lacunar infarction 16.17 14.16 3 686956 3374 89938114
Electrocardiogram T wave inversion 16.15 14.16 4 686955 3679 89937809
Bone lesion 16.10 14.16 15 686944 6422 89935066
Coronary artery stenosis 16.08 14.16 10 686949 5256 89936232
Aortic valve stenosis 16.07 14.16 6 686953 4234 89937254
Hyperpyrexia 16.04 14.16 8 686951 4753 89936735
Dry eye 16.02 14.16 326 686633 57605 89883883
Cryptococcal meningoencephalitis 16.00 14.16 12 686947 159 89941329
Uterine haemorrhage 15.98 14.16 8 686951 4744 89936744
Hepatitis fulminant 15.96 14.16 5 686954 3940 89937548
Diabetes mellitus 15.94 14.16 372 686587 64503 89876985
Leukaemia 15.92 14.16 9 686950 4983 89936505
Aortic valve incompetence 15.91 14.16 16 686943 6608 89934880
Upper limb fracture 15.88 14.16 97 686862 21481 89920007
White blood cell count increased 15.85 14.16 388 686571 66853 89874635
Groin pain 15.85 14.16 44 686915 12169 89929319
Multiple system atrophy 15.84 14.16 13 686946 198 89941290
Inability to afford medication 15.75 14.16 4 686955 3618 89937870
Embolism venous 15.74 14.16 4 686955 3616 89937872
Vulvovaginal candidiasis 15.68 14.16 5 686954 3895 89937593
Septic shock 15.65 14.16 502 686457 83658 89857830
Craniocerebral injury 15.64 14.16 3 686956 3295 89938193
Bronchiectasis 15.60 14.16 102 686857 22228 89919260
Procedural complication 15.54 14.16 13 686946 5865 89935623
Dental restoration failure 15.54 14.16 30 686929 1134 89940354
Blood test abnormal 15.52 14.16 94 686865 20858 89920630
Pelvic fracture 15.49 14.16 61 686898 15158 89926330
Hereditary motor and sensory neuropathy 15.43 14.16 10 686949 103 89941385
Communication disorder 15.43 14.16 3 686956 3263 89938225
Bordetella infection 15.41 14.16 6 686953 17 89941471
Visual field defect 15.36 14.16 19 686940 7147 89934341
Lung neoplasm 15.36 14.16 17 686942 6718 89934770
Abdominal adhesions 15.32 14.16 4 686955 3551 89937937
Wrong technique in device usage process 15.31 14.16 13 686946 5822 89935666
Cardiac valve disease 15.30 14.16 8 686951 4627 89936861
Vaginal haematoma 15.23 14.16 11 686948 137 89941351
Retinopathy 15.18 14.16 4 686955 3530 89937958
Swollen joint count 15.17 14.16 115 686844 8538 89932950
Taste disorder 15.08 14.16 590 686369 60956 89880532
Diabetes insipidus 15.07 14.16 3 686956 3209 89938279
Toe amputation 15.06 14.16 42 686917 2027 89939461
Blood chloride increased 15.05 14.16 3 686956 3207 89938281
Renal tubular disorder 15.03 14.16 3 686956 3204 89938284
Gastric ulcer haemorrhage 14.99 14.16 11 686948 5300 89936188
Disease complication 14.87 14.16 5 686954 3767 89937721
Radius fracture 14.87 14.16 6 686953 4038 89937450
Frustration tolerance decreased 14.86 14.16 23 686936 7873 89933615
Coronavirus infection 14.83 14.16 12 686947 5503 89935985
Vulvovaginal pain 14.80 14.16 4 686955 3470 89938018
Staphylococcal bacteraemia 14.79 14.16 21 686938 7448 89934040
Chronic lymphocytic leukaemia 14.79 14.16 3 686956 3167 89938321
Dermatitis 14.78 14.16 103 686856 22117 89919371
Occult blood positive 14.74 14.16 6 686953 4017 89937471
Pain in extremity 14.71 14.16 3736 683223 446793 89494695
Temporomandibular joint syndrome 14.70 14.16 6 686953 4011 89937477
Supraventricular extrasystoles 14.69 14.16 11 686948 5246 89936242
Disseminated large cell lymphoma 14.68 14.16 8 686951 58 89941430
Bladder disorder 14.59 14.16 38 686921 10734 89930754
Blood parathyroid hormone increased 14.56 14.16 4 686955 3433 89938055
Pneumonia bacterial 14.51 14.16 49 686910 12741 89928747
Ocular icterus 14.48 14.16 6 686953 3974 89937514
Panic disorder 14.42 14.16 3 686956 3112 89938376
Oxygen therapy 14.34 14.16 3 686956 3099 89938389
Foot operation 14.33 14.16 117 686842 8884 89932604
Dysgraphia 14.32 14.16 5 686954 3678 89937810
Systemic inflammatory response syndrome 14.26 14.16 17 686942 6499 89934989
Malignant melanoma 14.25 14.16 152 686807 12424 89929064
Non-cardiac chest pain 14.22 14.16 18 686941 6703 89934785
Vitreous floaters 14.19 14.16 22 686937 7527 89933961
Pulse abnormal 14.18 14.16 3 686956 3076 89938412
Urinary tract infection bacterial 14.18 14.16 16 686943 6269 89935219
Hair texture abnormal 14.17 14.16 9 686950 4678 89936810

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1948.06 13.76 3833 73834 634502 41909166
Drug ineffective 1548.82 13.76 3468 74199 626729 41916939
Joint swelling 1062.25 13.76 925 76742 67097 42476571
No adverse event 897.31 13.76 666 77001 38355 42505313
Synovitis 801.24 13.76 442 77225 15125 42528543
Contraindicated product administered 751.78 13.76 505 77162 24767 42518901
Rheumatoid arthritis 635.47 13.76 564 77103 41876 42501792
Intentional product use issue 606.65 13.76 700 76967 71133 42472535
Apparent death 591.94 13.76 231 77436 3477 42540191
Arthropathy 561.75 13.76 451 77216 29146 42514522
Bone erosion 556.88 13.76 232 77435 4171 42539497
Treatment failure 529.89 13.76 611 77056 62013 42481655
Diverticulitis 526.08 13.76 390 77277 22383 42521285
C-reactive protein abnormal 487.56 13.76 267 77400 8994 42534674
Therapeutic product effect decreased 469.64 13.76 460 77207 38690 42504978
Red blood cell sedimentation rate abnormal 395.72 13.76 175 77492 3661 42540007
Drug intolerance 360.13 13.76 576 77091 79848 42463820
Arthralgia 332.68 13.76 972 76695 204266 42339402
Immune effector cell-associated neurotoxicity syndrome 288.20 13.76 192 77475 9269 42534399
Drug eruption 285.72 13.76 276 77391 22799 42520869
Pain 280.93 13.76 1031 76636 243817 42299851
Urticaria 266.15 13.76 481 77186 73555 42470113
Toxicity to various agents 253.95 13.76 54 77613 229082 42314586
Stomatitis 234.12 13.76 367 77300 49962 42493706
Red blood cell sedimentation rate increased 231.41 13.76 171 77496 9753 42533915
Diarrhoea 201.36 13.76 332 77335 460517 42083151
Hypersensitivity 198.94 13.76 420 77247 71950 42471718
Blood pressure diastolic abnormal 197.90 13.76 129 77538 5999 42537669
Rheumatoid factor negative 197.26 13.76 73 77594 941 42542727
Drug hypersensitivity 195.67 13.76 506 77161 98883 42444785
Ill-defined disorder 192.51 13.76 190 77477 16106 42527562
Musculoskeletal stiffness 188.35 13.76 360 77307 57405 42486263
Pain in extremity 179.78 13.76 643 77024 149961 42393707
Hepatic function abnormal 178.85 13.76 330 77337 51237 42492431
Drug interaction 174.18 13.76 139 77528 266860 42276808
Pulmonary thrombosis 172.85 13.76 134 77533 8214 42535454
Bone cyst 169.24 13.76 75 77592 1576 42542092
Drug abuse 167.93 13.76 5 77662 104766 42438902
C-reactive protein increased 159.94 13.76 356 77311 63204 42480464
Vomiting 159.41 13.76 176 77491 289547 42254121
Peripheral swelling 158.89 13.76 441 77226 89829 42453839
Fatigue 156.85 13.76 352 77315 435289 42108379
Completed suicide 156.84 13.76 4 77663 96461 42447207
Anti-cyclic citrullinated peptide antibody positive 152.60 13.76 73 77594 1839 42541829
Blood pressure systolic abnormal 151.26 13.76 105 77562 5423 42538245
Terminal state 149.95 13.76 96 77571 4327 42539341
Knee arthroplasty 145.98 13.76 124 77543 8657 42535011
Haemophagocytic lymphohistiocytosis 145.88 13.76 173 77494 18049 42525619
Mobility decreased 145.81 13.76 244 77423 35062 42508606
Hypofibrinogenaemia 144.63 13.76 71 77596 1896 42541772
Hand deformity 140.83 13.76 87 77580 3681 42539987
Anaemia 140.61 13.76 183 77484 280095 42263573
Infusion related reaction 140.16 13.76 329 77338 60477 42483191
Blood pressure systolic increased 139.90 13.76 211 77456 27757 42515911
Localised infection 136.70 13.76 177 77490 20196 42523472
Overdose 136.27 13.76 16 77651 105248 42438420
Acute kidney injury 136.06 13.76 292 77375 367045 42176623
Limb discomfort 131.03 13.76 138 77529 12629 42531039
Cytokine release syndrome 130.00 13.76 265 77402 44262 42499406
Arthritis bacterial 129.85 13.76 98 77569 5770 42537898
Dehydration 129.83 13.76 48 77619 141719 42401949
Febrile neutropenia 129.60 13.76 90 77577 185613 42358055
Arthritis 129.57 13.76 256 77411 41809 42501859
Joint ankylosis 127.70 13.76 62 77605 1615 42542053
Herpes zoster 127.55 13.76 243 77424 38634 42505034
Skin ulcer 119.41 13.76 187 77480 25414 42518254
Drug ineffective for unapproved indication 118.84 13.76 261 77406 45902 42497766
Confusional state 115.90 13.76 82 77585 167515 42376153
Mass 112.81 13.76 107 77560 8632 42535036
Interstitial lung disease 111.12 13.76 355 77312 78107 42465561
Dyspnoea 110.86 13.76 424 77243 442197 42101471
Death 109.45 13.76 465 77202 470720 42072948
Bronchopulmonary aspergillosis 106.42 13.76 153 77514 19276 42524392
Swelling 105.40 13.76 277 77390 54608 42489060
Joint arthroplasty 105.38 13.76 46 77621 931 42542737
Dizziness 105.32 13.76 183 77484 249071 42294597
Somnolence 102.98 13.76 65 77602 141040 42402628
Hyponatraemia 102.33 13.76 29 77638 101433 42442235
Alanine aminotransferase abnormal 101.57 13.76 79 77588 4865 42538803
Drug specific antibody present 100.12 13.76 72 77595 3934 42539734
Loss of personal independence in daily activities 99.33 13.76 255 77412 49561 42494107
Decreased appetite 97.88 13.76 125 77542 193012 42350656
Constipation 97.75 13.76 91 77576 162200 42381468
Asthenia 93.54 13.76 236 77431 280557 42263111
Blood pressure diastolic increased 93.49 13.76 84 77583 6321 42537347
Epistaxis 92.46 13.76 300 77367 66526 42477142
Intestinal sepsis 89.68 13.76 38 77629 713 42542955
Bladder transitional cell carcinoma 88.04 13.76 57 77610 2619 42541049
Deep vein thrombosis 87.78 13.76 324 77343 76633 42467035
Nasopharyngitis 87.06 13.76 343 77324 83653 42460015
Drug tolerance decreased 86.95 13.76 54 77613 2306 42541362
Malignant neoplasm progression 84.65 13.76 46 77621 108354 42435314
Infection 84.49 13.76 416 77251 111652 42432016
General physical health deterioration 83.99 13.76 91 77576 151155 42392513
Gastric disorder 80.63 13.76 104 77563 11818 42531850
Polyarthritis 80.61 13.76 70 77597 5034 42538634
Blood pressure diastolic decreased 80.56 13.76 97 77570 10278 42533390
Incorrect dose administered 79.85 13.76 4 77663 52970 42490698
Disability 79.17 13.76 74 77593 5859 42537809
Hypokalaemia 79.10 13.76 17 77650 71704 42471964
Joint lock 78.63 13.76 42 77625 1343 42542325
Seizure 78.16 13.76 63 77604 120498 42423170
Gait inability 77.70 13.76 145 77522 22688 42520980
Hospitalisation 77.28 13.76 20 77647 74310 42469358
Impaired work ability 76.38 13.76 102 77565 11989 42531679
Systemic candida 76.15 13.76 69 77598 5250 42538418
Rhabdomyolysis 75.57 13.76 24 77643 77995 42465673
Hepatic steatosis 75.24 13.76 138 77529 21310 42522358
Cytology abnormal 75.16 13.76 28 77639 368 42543300
X-ray abnormal 75.06 13.76 30 77637 482 42543186
Product dose omission issue 75.02 13.76 103 77564 154262 42389406
Osteoarthritis 74.49 13.76 148 77519 24257 42519411
Intestinal polyp 74.24 13.76 40 77627 1302 42542366
Hyperkalaemia 74.02 13.76 27 77640 80431 42463237
Weight increased 73.81 13.76 390 77277 107593 42436075
Sleep disorder due to general medical condition, insomnia type 73.57 13.76 41 77626 1428 42542240
Osteolysis 73.09 13.76 57 77610 3523 42540145
Oxygen saturation decreased 72.63 13.76 271 77396 64416 42479252
Loss of consciousness 72.38 13.76 39 77628 92315 42451353
Hepatitis B virus test positive 71.05 13.76 26 77641 324 42543344
Rheumatoid nodule 70.69 13.76 52 77615 2943 42540725
Coma 69.63 13.76 8 77659 53546 42490122
Syncope 69.51 13.76 48 77619 99358 42444310
Dysphagia 69.31 13.76 23 77644 72696 42470972
Inappropriate schedule of product administration 68.81 13.76 45 77622 95857 42447811
Heart rate decreased 68.71 13.76 183 77484 36349 42507319
Abdominal distension 67.83 13.76 23 77644 71712 42471956
Cardiac failure congestive 67.30 13.76 36 77631 85566 42458102
Skin laceration 64.59 13.76 102 77565 13956 42529712
Disability assessment scale score increased 63.04 13.76 25 77642 393 42543275
Pyrexia 62.07 13.76 442 77225 393600 42150068
Physical disability 61.87 13.76 40 77627 1833 42541835
Drug effective for unapproved indication 59.85 13.76 67 77600 6566 42537102
Vision blurred 58.66 13.76 13 77654 53686 42489982
Rheumatoid factor positive 58.30 13.76 29 77638 797 42542871
Septic shock 57.84 13.76 324 77343 91348 42452320
Malaise 57.02 13.76 197 77470 211959 42331709
Hallucination 56.92 13.76 17 77650 57490 42486178
Suicidal ideation 56.08 13.76 10 77657 48151 42495517
Photosensitivity reaction 55.39 13.76 90 77577 12612 42531056
Lymphoedema 55.30 13.76 56 77611 4892 42538776
Liver function test increased 54.80 13.76 116 77551 19882 42523786
Pulmonary fibrosis 54.64 13.76 138 77529 26543 42517125
Skin exfoliation 54.54 13.76 6 77661 41547 42502121
Fall 54.49 13.76 231 77436 234289 42309379
Depression 54.39 13.76 74 77593 111289 42432379
Abdominal pain 53.83 13.76 173 77494 190298 42353370
Hepatitis 53.62 13.76 139 77528 27161 42516507
Intentional product misuse 53.28 13.76 23 77644 61877 42481791
Seronegative arthritis 52.82 13.76 31 77636 1193 42542475
Joint stiffness 51.97 13.76 86 77581 12236 42531432
Short stature 51.67 13.76 22 77645 418 42543250
Immobile 50.89 13.76 42 77625 2816 42540852
Injection site pain 50.51 13.76 21 77646 57777 42485891
Growth retardation 50.26 13.76 39 77628 2393 42541275
International normalised ratio increased 49.98 13.76 13 77654 48155 42495513
Muscle abscess 49.07 13.76 27 77640 917 42542751
Plasma cell myeloma 47.21 13.76 14 77653 47564 42496104
Suicide attempt 46.78 13.76 13 77654 46087 42497581
Pulmonary embolism 46.60 13.76 375 77292 119237 42424431
Blood glucose increased 45.91 13.76 40 77627 73659 42470009
Agitation 45.02 13.76 31 77636 64283 42479385
Therapy non-responder 44.47 13.76 204 77463 53155 42490513
Hypoglycaemia 44.42 13.76 27 77640 59827 42483841
Nodule 44.40 13.76 81 77586 12453 42531215
Blood creatinine increased 44.36 13.76 83 77584 109920 42433748
Orthostatic hypotension 43.96 13.76 3 77664 30567 42513101
Prerenal failure 43.84 13.76 36 77631 2397 42541271
Hip arthroplasty 43.50 13.76 51 77616 5254 42538414
Anxiety 43.09 13.76 95 77572 118465 42425203
Stent placement 43.07 13.76 51 77616 5309 42538359
Gastrointestinal haemorrhage 42.80 13.76 70 77597 97656 42446012
Neuropathy peripheral 42.72 13.76 75 77592 101778 42441890
Unevaluable event 42.44 13.76 6 77661 34282 42509386
Aggression 42.02 13.76 14 77653 44149 42499519
Oral surgery 41.70 13.76 21 77646 593 42543075
Restlessness 41.68 13.76 3 77664 29246 42514422
Wrong technique in product usage process 41.48 13.76 13 77654 42622 42501046
Juvenile idiopathic arthritis 41.29 13.76 36 77631 2603 42541065
Suture rupture 40.44 13.76 19 77648 459 42543209
Coronary artery disease 40.19 13.76 24 77643 53696 42489972
Myalgia 40.07 13.76 71 77596 96009 42447659
Body temperature decreased 39.95 13.76 84 77583 14329 42529339
Gastrointestinal perforation 39.94 13.76 45 77622 4441 42539227
Disseminated mucormycosis 39.41 13.76 27 77640 1364 42542304
Blood pressure fluctuation 39.19 13.76 123 77544 26785 42516883
Dysarthria 38.97 13.76 12 77655 39795 42503873
Liver disorder 38.72 13.76 159 77508 39485 42504183
Mycotic endophthalmitis 38.71 13.76 15 77652 221 42543447
Disseminated intravascular coagulation 38.59 13.76 116 77551 24678 42518990
Medical device implantation 38.58 13.76 20 77647 601 42543067
Nausea 38.57 13.76 501 77166 396298 42147370
Atrial fibrillation 38.57 13.76 128 77539 139465 42404203
Musculoskeletal discomfort 38.44 13.76 65 77602 9411 42534257
Blood fibrinogen decreased 38.21 13.76 28 77639 1575 42542093
Muscle spasms 38.10 13.76 278 77389 85766 42457902
Osteoporosis 38.02 13.76 84 77583 14822 42528846
Hypomagnesaemia 37.67 13.76 4 77663 28484 42515184
Disorientation 37.41 13.76 10 77657 36379 42507289
Hepatic cirrhosis 37.35 13.76 99 77568 19603 42524065
Skin mass 37.34 13.76 45 77622 4771 42538897
Infectious pleural effusion 37.25 13.76 37 77630 3158 42540510
Intestinal perforation 36.92 13.76 69 77598 10805 42532863
Panniculitis 36.66 13.76 31 77636 2150 42541518
Hepatic enzyme abnormal 35.92 13.76 38 77629 3494 42540174
Tubulointerstitial nephritis 35.77 13.76 7 77660 31541 42512127
Dry mouth 35.64 13.76 14 77653 39865 42503803
Mucosal inflammation 35.63 13.76 23 77644 49351 42494317
Spinal cord injury cervical 35.42 13.76 15 77652 281 42543387
Bursitis 35.40 13.76 50 77617 6194 42537474
Abscess 34.89 13.76 79 77588 14169 42529499
Aspergillus infection 34.62 13.76 84 77583 15753 42527915
Nightmare 34.43 13.76 3 77664 25009 42518659
Lactic acidosis 34.17 13.76 20 77647 45241 42498427
Cataract 34.15 13.76 128 77539 30476 42513192
Mental status changes 34.14 13.76 17 77650 42098 42501570
Haematuria 34.06 13.76 33 77634 57766 42485902
Cytokine storm 34.02 13.76 21 77646 887 42542781
Inflammation 33.25 13.76 136 77531 33711 42509957
Therapeutic product effect incomplete 33.02 13.76 232 77435 70707 42472961
Arthritis infective 32.88 13.76 39 77628 4067 42539601
Cardio-respiratory arrest 32.82 13.76 35 77632 58601 42485067
Musculoskeletal pain 32.78 13.76 134 77533 33206 42510462
Renal impairment 31.89 13.76 99 77568 110129 42433539
Haematemesis 31.62 13.76 8 77659 30191 42513477
Chronic kidney disease 31.46 13.76 24 77643 47217 42496451
Depressed level of consciousness 31.14 13.76 25 77642 47945 42495723
Red blood cell sedimentation rate 30.69 13.76 21 77646 1059 42542609
Gait disturbance 30.53 13.76 85 77582 97915 42445753
Spinal instability 30.40 13.76 17 77650 596 42543072
Hypotension 30.15 13.76 312 77355 257319 42286349
Soft tissue disorder 30.10 13.76 19 77648 835 42542833
Unresponsive to stimuli 29.80 13.76 10 77657 31393 42512275
Ejection fraction decreased 29.47 13.76 3 77664 22084 42521584
Large intestine perforation 29.30 13.76 58 77609 9478 42534190
Full blood count abnormal 29.26 13.76 9 77658 29867 42513801
Wheezing 29.23 13.76 34 77633 54747 42488921
Hand fracture 29.08 13.76 31 77636 2875 42540793
Scleritis 28.99 13.76 18 77649 768 42542900
Thrombocytopenia 28.62 13.76 216 77451 190063 42353605
Lethargy 28.53 13.76 26 77641 46864 42496804
Rectal haemorrhage 28.45 13.76 29 77638 49577 42494091
Irritability 28.41 13.76 8 77659 28120 42515548
Incorrect route of product administration 28.39 13.76 5 77662 24300 42519368
Bradycardia 28.25 13.76 72 77595 85412 42458256
Fine motor skill dysfunction 28.11 13.76 27 77640 2212 42541456
Diabetes mellitus 27.66 13.76 196 77471 59891 42483777
Tooth fracture 27.51 13.76 36 77631 4148 42539520
Diabetic ketoacidosis 27.48 13.76 4 77663 22363 42521305
Medication error 27.46 13.76 13 77654 33141 42510527
Pharyngitis 27.22 13.76 54 77613 8836 42534832
Soft tissue swelling 26.89 13.76 17 77650 749 42542919
Chills 26.84 13.76 85 77582 93981 42449687
Granuloma skin 26.83 13.76 20 77647 1155 42542513
Pancytopenia 26.67 13.76 117 77550 117626 42426042
Treatment noncompliance 26.57 13.76 18 77649 37654 42506014
Pseudomonal bacteraemia 26.56 13.76 27 77640 2369 42541299
Abscess limb 26.55 13.76 35 77632 4062 42539606
Ascites 26.33 13.76 39 77628 56639 42487029
COVID-19 pneumonia 26.31 13.76 93 77574 21520 42522148
Neoplasm progression 26.21 13.76 10 77657 28990 42514678
Urinary retention 26.18 13.76 23 77644 42191 42501477
Dysgeusia 25.96 13.76 15 77652 34174 42509494
Metabolic acidosis 25.77 13.76 34 77633 51824 42491844
Endocarditis 25.55 13.76 50 77617 8102 42535566
Necrotising fasciitis 25.18 13.76 36 77631 4510 42539158
Muscle strain 24.99 13.76 36 77631 4541 42539127
Drug use disorder 24.97 13.76 57 77610 10276 42533392
Depressed mood 24.86 13.76 6 77661 23378 42520290
Dyspnoea exertional 24.79 13.76 33 77634 50115 42493553
Hypocalcaemia 24.73 13.76 12 77655 30161 42513507
Hepatic enzyme increased 24.47 13.76 155 77512 45629 42498039
Diverticular perforation 24.47 13.76 32 77635 3684 42539984
Skin injury 24.38 13.76 27 77640 2614 42541054
Disturbance in attention 24.29 13.76 12 77655 29854 42513814
Blood pressure increased 24.13 13.76 288 77379 101640 42442028
Ulcerative keratitis 24.01 13.76 24 77643 2064 42541604
Rheumatoid factor 23.99 13.76 8 77659 74 42543594
Chondropathy 23.99 13.76 19 77648 1201 42542467
Drug withdrawal syndrome 23.97 13.76 5 77662 21544 42522124
Hepatitis E antibody positive 23.79 13.76 11 77656 256 42543412
Amnesia 23.78 13.76 11 77656 28426 42515242
Polyarteritis nodosa 23.73 13.76 12 77655 342 42543326
Acetabulum fracture 23.69 13.76 13 77654 439 42543229
Vertigo 23.45 13.76 17 77650 34330 42509338
Cushingoid 23.37 13.76 30 77637 3392 42540276
Presyncope 23.30 13.76 6 77661 22381 42521287
Ventricular fibrillation 23.18 13.76 13 77654 30110 42513558
Pneumonia bacterial 23.10 13.76 72 77595 15620 42528048
Testicular seminoma (pure) 23.06 13.76 10 77657 199 42543469
Stress 22.99 13.76 28 77639 44184 42499484
Intercepted product storage error 22.98 13.76 12 77655 366 42543302
Rheumatoid factor increased 22.94 13.76 15 77652 701 42542967
Human herpesvirus 6 encephalitis 22.77 13.76 14 77653 587 42543081
Cystitis bacterial 22.74 13.76 10 77657 206 42543462
Trichodysplasia spinulosa 22.54 13.76 12 77655 381 42543287
Squamous cell carcinoma of lung 22.46 13.76 24 77643 2232 42541436
Hepatitis E virus test positive 22.29 13.76 11 77656 297 42543371
Accidental exposure to product 22.14 13.76 5 77662 20388 42523280
Pneumonia streptococcal 22.00 13.76 21 77646 1707 42541961
Visual acuity reduced 21.89 13.76 3 77664 17547 42526121
Septic arthritis staphylococcal 21.79 13.76 13 77654 516 42543152
Frequent bowel movements 21.78 13.76 6 77661 21401 42522267
Delirium 21.71 13.76 39 77628 52480 42491188
Hypophagia 21.67 13.76 11 77656 26945 42516723
Serotonin syndrome 21.61 13.76 10 77657 25835 42517833
SAPHO syndrome 21.56 13.76 12 77655 417 42543251
Arteriosclerosis coronary artery 21.48 13.76 4 77663 18673 42524995
Adverse drug reaction 21.33 13.76 22 77645 37412 42506256
Joint range of motion decreased 21.27 13.76 45 77622 7708 42535960
Neutrophil count increased 21.21 13.76 5 77662 19799 42523869
Achromobacter infection 21.14 13.76 9 77658 171 42543497
Bronchopleural fistula 21.06 13.76 14 77653 673 42542995
Blood parathyroid hormone decreased 20.98 13.76 20 77647 1623 42542045
White blood cell count increased 20.96 13.76 31 77636 45056 42498612
Generalised tonic-clonic seizure 20.86 13.76 11 77656 26368 42517300
Infective spondylitis 20.83 13.76 10 77657 254 42543414
Tender joint count decreased 20.61 13.76 10 77657 260 42543408
Swollen joint count decreased 20.61 13.76 10 77657 260 42543408
Herpes simplex viraemia 20.45 13.76 8 77659 121 42543547
Impaired healing 20.43 13.76 73 77594 16980 42526688
Pneumothorax 20.34 13.76 91 77576 23452 42520216
Gout 20.33 13.76 13 77654 28042 42515626
End stage renal disease 20.25 13.76 3 77664 16555 42527113
Mucormycosis 20.22 13.76 42 77625 7101 42536567
Erysipelas 20.20 13.76 39 77628 6257 42537411
Sarcoidosis 20.16 13.76 29 77638 3653 42540015
Lymphocele 20.07 13.76 19 77648 1528 42542140
Troponin increased 20.05 13.76 5 77662 19057 42524611
Myocardial ischaemia 20.01 13.76 4 77663 17758 42525910
Cerebrovascular accident 19.96 13.76 100 77567 97060 42446608
Pollakiuria 19.94 13.76 8 77659 22497 42521171
Paraesthesia 19.83 13.76 68 77599 73391 42470277
Lung abscess 19.80 13.76 27 77640 3236 42540432
Chest pain 19.75 13.76 161 77506 139369 42404299
Interleukin level increased 19.69 13.76 15 77652 895 42542773
Drug tolerance 19.63 13.76 27 77640 3263 42540405
Myelosuppression 19.62 13.76 27 77640 40434 42503234
Myasthenia gravis 19.56 13.76 3 77664 16134 42527534
Bone hypertrophy 19.55 13.76 10 77657 292 42543376
Ataxia 19.54 13.76 3 77664 16122 42527546
Lower respiratory tract congestion 19.53 13.76 19 77648 1581 42542087
Sleep disorder due to a general medical condition 19.52 13.76 4 77663 17449 42526219
Oral disorder 19.51 13.76 33 77634 4779 42538889
Multifocal motor neuropathy 19.50 13.76 8 77659 138 42543530
Drug reaction with eosinophilia and systemic symptoms 19.49 13.76 29 77638 42046 42501622
Rheumatoid lung 19.49 13.76 15 77652 909 42542759
Respiratory arrest 19.49 13.76 14 77653 28410 42515258
Joint injury 19.48 13.76 65 77602 14611 42529057
Joint destruction 19.46 13.76 11 77656 394 42543274
Tooth injury 19.44 13.76 17 77650 1234 42542434
Oedema 19.43 13.76 41 77626 51960 42491708
Investigation abnormal 19.26 13.76 13 77654 641 42543027
Psychotic disorder 19.24 13.76 15 77652 29193 42514475
Cubital tunnel syndrome 19.10 13.76 9 77658 219 42543449
Shoulder operation 19.07 13.76 18 77649 1443 42542225
Palpitations 19.02 13.76 40 77627 50757 42492911
Injection site hypersensitivity 18.99 13.76 11 77656 413 42543255
Jaundice 18.96 13.76 21 77646 34568 42509100
Myoclonus 18.90 13.76 4 77663 17061 42526607
Blood alkaline phosphatase increased 18.86 13.76 20 77647 33577 42510091
Head injury 18.76 13.76 7 77660 20575 42523093
Circulatory collapse 18.48 13.76 10 77657 23626 42520042
Therapeutic response decreased 18.37 13.76 123 77544 36889 42506779
Excessive cerumen production 18.32 13.76 10 77657 334 42543334
Joint effusion 18.27 13.76 36 77631 5861 42537807
Upper gastrointestinal haemorrhage 18.20 13.76 17 77650 30282 42513386
Abnormal behaviour 18.17 13.76 13 77654 26438 42517230
Clostridium difficile colitis 18.12 13.76 8 77659 21244 42522424
Hyperhidrosis 18.12 13.76 94 77573 90418 42453250
Giant cell arteritis 18.05 13.76 16 77651 1182 42542486
Bacterial myositis 18.00 13.76 4 77663 5 42543663
Pulmonary toxicity 17.96 13.76 45 77622 8610 42535058
Hepatic encephalopathy 17.91 13.76 4 77663 16438 42527230
Stevens-Johnson syndrome 17.90 13.76 9 77658 22169 42521499
Osteopenia 17.88 13.76 37 77630 6241 42537427
Memory impairment 17.61 13.76 41 77626 50181 42493487
Fungaemia 17.61 13.76 25 77642 3111 42540557
Injection related reaction 17.56 13.76 12 77655 604 42543064
Optic nerve operation 17.48 13.76 11 77656 481 42543187
Blood potassium increased 17.41 13.76 6 77661 18530 42525138
Toxic epidermal necrolysis 17.29 13.76 14 77653 26736 42516932
Staphylococcal bacteraemia 17.27 13.76 52 77615 11069 42532599
Infected dermal cyst 17.22 13.76 14 77653 919 42542749
Pneumatosis intestinalis 17.20 13.76 31 77636 4721 42538947
Gastrointestinal infection 17.19 13.76 38 77629 6705 42536963
Solar urticaria 17.16 13.76 5 77662 28 42543640
Cardiogenic shock 17.06 13.76 24 77643 35616 42508052
Pneumonia staphylococcal 17.05 13.76 26 77641 3450 42540218
Polychondritis 17.03 13.76 10 77657 385 42543283
Purpura fulminans 17.00 13.76 8 77659 194 42543474
Myelodysplastic syndrome unclassifiable 16.99 13.76 7 77660 122 42543546
Myeloproliferative neoplasm 16.95 13.76 13 77654 784 42542884
Perineal infection 16.94 13.76 12 77655 640 42543028
Wound infection 16.91 13.76 43 77624 8303 42535365
Metastatic bronchial carcinoma 16.89 13.76 10 77657 391 42543277
Vein disorder 16.89 13.76 20 77647 2082 42541586
Toxic shock syndrome streptococcal 16.87 13.76 5 77662 30 42543638
Blood potassium decreased 16.87 13.76 8 77659 20376 42523292
Infective chondritis 16.86 13.76 4 77663 8 42543660
Splenic abscess 16.84 13.76 12 77655 646 42543022
Pulmonary congestion 16.79 13.76 4 77663 15726 42527942
Skin papilloma 16.78 13.76 23 77644 2771 42540897
Mental disorder 16.66 13.76 6 77661 18023 42525645
Hepatic fibrosis 16.64 13.76 31 77636 4841 42538827
Meningitis listeria 16.61 13.76 12 77655 660 42543008
Rash vesicular 16.56 13.76 25 77642 3288 42540380
Pneumocystis jirovecii pneumonia 16.53 13.76 90 77577 25091 42518577
Ankle operation 16.51 13.76 9 77658 300 42543368
Cardiomegaly 16.51 13.76 5 77662 16761 42526907
Impaired quality of life 16.38 13.76 3 77664 14174 42529494
Rhinocerebral mucormycosis 16.33 13.76 12 77655 678 42542990
Angioedema 16.28 13.76 33 77634 42444 42501224
Rash maculo-papular 16.28 13.76 27 77640 37476 42506192
Eczema 16.27 13.76 23 77644 34063 42509605
Gastritis 16.15 13.76 12 77655 23935 42519733
Paranoia 16.14 13.76 3 77664 14023 42529645
Visual impairment 16.10 13.76 34 77633 43079 42500589
Obesity 16.04 13.76 5 77662 16454 42527214
Atlantoaxial instability 16.02 13.76 10 77657 431 42543237
Long QT syndrome 15.98 13.76 24 77643 3143 42540525
Obstructive airways disorder 15.95 13.76 13 77654 24746 42518922
JC virus CSF test positive 15.93 13.76 7 77660 144 42543524
Anorectal agenesis 15.93 13.76 3 77664 0 42543668
Dysphonia 15.90 13.76 17 77650 28433 42515235
Balance disorder 15.84 13.76 40 77627 47605 42496063
Alopecia 15.80 13.76 18 77649 29258 42514410
Ventricular tachycardia 15.79 13.76 19 77648 30141 42513527
Flushing 15.76 13.76 27 77640 37001 42506667
Oesophageal rupture 15.75 13.76 10 77657 444 42543224
Liver function test 15.70 13.76 6 77661 85 42543583
Lymphocyte adoptive therapy 15.70 13.76 6 77661 85 42543583
Speech disorder 15.61 13.76 18 77649 29103 42514565
Cardiac disorder 15.56 13.76 42 77625 48890 42494778
Foetal exposure during pregnancy 15.51 13.76 40 77627 47271 42496397
Necrotising soft tissue infection 15.50 13.76 7 77660 154 42543514
Product administration error 15.49 13.76 7 77660 18336 42525332
Hyperferritinaemia 15.44 13.76 11 77656 592 42543076
Oropharyngitis fungal 15.38 13.76 7 77660 157 42543511
Poor venous access 15.36 13.76 38 77629 7214 42536454
Chronic obstructive pulmonary disease 15.35 13.76 61 77606 63053 42480615
Chromaturia 15.33 13.76 5 77662 15984 42527684
Device issue 15.31 13.76 3 77664 13506 42530162
Asthma 15.30 13.76 60 77607 62254 42481414
Pulmonary oedema 15.29 13.76 48 77619 53224 42490444
Product prescribing error 15.27 13.76 15 77652 26097 42517571
Gingival ulceration 15.26 13.76 10 77657 469 42543199
Alanine aminotransferase increased 15.24 13.76 236 77431 88170 42455498
SARS-CoV-2 sepsis 15.23 13.76 8 77659 247 42543421
Staphylococcal infection 15.17 13.76 119 77548 37524 42506144
Faeces discoloured 15.15 13.76 6 77661 17008 42526660
Pneumonia 15.14 13.76 926 76741 421223 42122445
Histoplasmosis cutaneous 15.12 13.76 5 77662 45 42543623
Ileus 15.10 13.76 8 77659 19131 42524537
Bradycardia foetal 15.09 13.76 9 77658 357 42543311
Hypersomnia 15.06 13.76 4 77663 14614 42529054
Pulmonary cavitation 15.02 13.76 15 77652 1289 42542379
Gastric perforation 14.98 13.76 23 77644 3070 42540598
Osteoporotic fracture 14.91 13.76 16 77651 1495 42542173
Cholestasis 14.90 13.76 23 77644 32856 42510812
Scalloped tongue 14.83 13.76 4 77663 16 42543652
Wound 14.67 13.76 66 77601 17051 42526617
Fracture 14.63 13.76 40 77627 8063 42535605
Tachycardia 14.59 13.76 116 77551 100971 42442697
Nasal crusting 14.58 13.76 10 77657 506 42543162
Blood cholesterol abnormal 14.55 13.76 18 77649 1961 42541707
Liver injury 14.34 13.76 71 77596 19077 42524591
Hypogammaglobulinaemia 14.33 13.76 51 77616 11840 42531828
Acute respiratory distress syndrome 14.31 13.76 99 77568 30009 42513659
Full blood count decreased 14.26 13.76 10 77657 20550 42523118
Viral infection 14.24 13.76 12 77655 22471 42521197
Scrotal infection 14.20 13.76 12 77655 831 42542837
Discomfort 14.17 13.76 15 77652 25204 42518464
Sepsis 13.91 13.76 468 77199 198866 42344802
Still's disease 13.86 13.76 3 77664 3 42543665

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Synovitis 3856.15 13.75 5944 586019 268148 109729188
Joint swelling 3774.58 13.75 7707 584256 435138 109562198
Contraindicated product administered 3601.66 13.75 5462 586501 242805 109754531
Drug intolerance 3146.96 13.75 6804 585159 399708 109597628
Arthropathy 2975.51 13.75 5436 586527 282086 109715250
Treatment failure 2608.41 13.75 5033 586930 272201 109725135
Drug ineffective 2562.02 13.75 15334 576629 1505206 108492130
Therapeutic product effect decreased 2345.10 13.75 4474 587489 239842 109757494
Hand deformity 2076.38 13.75 3985 587978 214521 109782815
Acute kidney injury 1932.60 13.75 509 591454 634921 109362415
Pemphigus 1895.21 13.75 3795 588168 210775 109786561
Toxicity to various agents 1868.80 13.75 199 591764 480356 109516980
Swelling 1862.03 13.75 5082 586881 345959 109651377
Systemic lupus erythematosus 1845.76 13.75 4152 587811 250186 109747150
Infusion related reaction 1780.06 13.75 5270 586693 375892 109621444
Glossodynia 1777.67 13.75 3771 588192 218233 109779103
Anti-cyclic citrullinated peptide antibody positive 1745.72 13.75 3333 588630 178651 109818685
Hepatic enzyme increased 1739.04 13.75 4683 587280 316209 109681127
Hypersensitivity 1716.78 13.75 5404 586559 398594 109598742
Drug interaction 1603.62 13.75 358 591605 499825 109497511
Rheumatoid factor positive 1597.40 13.75 2672 589291 128968 109868368
C-reactive protein abnormal 1534.48 13.75 2603 589360 127092 109870244
Arthralgia 1529.12 13.75 8205 583758 771427 109225909
Anaemia 1525.03 13.75 514 591449 546572 109450764
Wound 1457.76 13.75 3604 588359 230833 109766503
Pericarditis 1453.86 13.75 3454 588509 215660 109781676
Death 1412.14 13.75 1012 590951 697857 109299479
Helicobacter infection 1349.89 13.75 2997 588966 178880 109818456
Duodenal ulcer perforation 1322.01 13.75 2931 589032 174769 109822567
Musculoskeletal stiffness 1162.47 13.75 3716 588247 276106 109721230
Folliculitis 1155.47 13.75 2683 589280 164970 109832366
Febrile neutropenia 1148.15 13.75 165 591798 316602 109680734
Impaired healing 1141.95 13.75 2947 589016 193770 109803566
Alopecia 1133.43 13.75 4401 587562 360352 109636984
Abdominal discomfort 1100.87 13.75 4598 587365 389260 109608076
Peripheral swelling 1094.54 13.75 4672 587291 399362 109597974
Ill-defined disorder 1055.54 13.75 2487 589476 154366 109842970
Muscle injury 1034.07 13.75 2311 589652 138496 109858840
Pain 1014.57 13.75 8635 583328 946320 109051016
Red blood cell sedimentation rate abnormal 1013.37 13.75 925 591038 23584 109973752
Irritable bowel syndrome 1008.02 13.75 2513 589450 161702 109835634
Drug hypersensitivity 932.62 13.75 4845 587118 449245 109548091
Drug abuse 919.17 13.75 5 591958 177406 109819930
Sleep disorder due to general medical condition, insomnia type 913.17 13.75 1853 590110 103790 109893546
Lower respiratory tract infection 907.19 13.75 3114 588849 239992 109757344
Dehydration 889.10 13.75 203 591760 279308 109718028
Fibromyalgia 878.34 13.75 2448 589515 168461 109828875
Blister 858.40 13.75 2924 589039 224452 109772884
Rheumatic fever 854.55 13.75 1971 589992 120608 109876728
Nasopharyngitis 852.32 13.75 4269 587694 390092 109607244
Mobility decreased 838.95 13.75 2987 588976 234435 109762901
Hyponatraemia 827.90 13.75 97 591866 217556 109779780
Product dose omission issue 816.28 13.75 350 591613 321432 109675904
Discomfort 804.23 13.75 2754 589209 211953 109785383
Psoriatic arthropathy 801.13 13.75 2596 589367 194165 109803171
Stomatitis 796.24 13.75 3208 588755 267034 109730302
Infection 779.09 13.75 3916 588047 358284 109639052
Red blood cell sedimentation rate increased 767.18 13.75 1448 590515 76854 109920482
Somnolence 764.94 13.75 317 591646 297132 109700204
Weight increased 728.37 13.75 4279 587684 415365 109581971
Malignant neoplasm progression 713.09 13.75 59 591904 174508 109822828
Sinusitis 688.06 13.75 3278 588685 293410 109703926
Inflammation 687.49 13.75 2437 589526 190801 109806535
Bursitis 687.28 13.75 1881 590082 128037 109869299
Intentional overdose 684.96 13.75 4 591959 132497 109864839
Blood cholesterol increased 669.08 13.75 2344 589619 182441 109814895
Bone erosion 668.83 13.75 1019 590944 45352 109951984
Type 2 diabetes mellitus 668.53 13.75 2279 589684 174953 109822383
Seizure 667.64 13.75 179 591784 221006 109776330
Maternal exposure during pregnancy 641.74 13.75 2885 589078 251998 109745338
Intentional product use issue 640.72 13.75 2828 589135 245078 109752258
Hypotension 628.70 13.75 1153 590810 522696 109474640
Constipation 620.25 13.75 600 591363 357186 109640150
C-reactive protein increased 606.98 13.75 2543 589420 215376 109781960
Swollen joint count increased 590.40 13.75 1352 590611 82309 109915027
Hyperkalaemia 580.11 13.75 37 591926 135759 109861577
Cardiac arrest 562.95 13.75 176 591787 196577 109800759
Osteoarthritis 562.57 13.75 2199 589764 180424 109816912
Facet joint syndrome 557.65 13.75 1447 590516 95381 109901955
No adverse event 554.27 13.75 1223 590740 72616 109924720
Joint range of motion decreased 551.46 13.75 1668 590295 120164 109877172
Neutropenia 530.93 13.75 738 591225 373882 109623454
Rhabdomyolysis 522.79 13.75 30 591933 120371 109876965
Dyspnoea 520.43 13.75 3631 588332 1103241 108894095
Rash 515.89 13.75 6679 585284 814285 109183051
Bradycardia 514.67 13.75 103 591860 155414 109841922
Atrial fibrillation 509.68 13.75 298 591665 229344 109767992
Cardiac failure congestive 508.17 13.75 96 591867 150904 109846432
Musculoskeletal pain 506.62 13.75 2132 589831 180891 109816445
Pancytopenia 492.81 13.75 253 591710 209360 109787976
Inappropriate schedule of product administration 492.01 13.75 237 591726 203400 109793936
Loss of personal independence in daily activities 482.91 13.75 1832 590131 148188 109849148
Neuropathy peripheral 482.26 13.75 178 591785 179099 109818237
Renal failure 481.99 13.75 309 591654 226265 109771071
Gastrointestinal disorder 481.55 13.75 2561 589402 239391 109757945
Gastrointestinal haemorrhage 466.49 13.75 152 591811 165366 109831970
Lip dry 464.01 13.75 1382 590581 98701 109898635
Injection site pain 461.47 13.75 187 591776 177735 109819601
Hypoglycaemia 461.26 13.75 44 591919 116060 109881276
Tremor 460.87 13.75 254 591709 201978 109795358
Suicide attempt 454.37 13.75 24 591939 103370 109893966
Coeliac disease 452.24 13.75 822 591141 42365 109954971
Blood pressure diastolic abnormal 447.59 13.75 619 591344 25196 109972140
Liver injury 443.70 13.75 1787 590176 148626 109848710
Sciatica 437.97 13.75 1286 590677 91113 109906223
Cardiac failure 434.34 13.75 231 591732 187395 109809941
Depressed level of consciousness 424.45 13.75 51 591912 112227 109885109
Disease progression 423.01 13.75 409 591554 243625 109753711
Syncope 422.93 13.75 282 591681 202254 109795082
Product use issue 422.48 13.75 2987 588976 308708 109688628
Rheumatoid nodule 418.75 13.75 530 591433 19766 109977570
Coma 418.47 13.75 65 591898 117804 109879532
Diarrhoea 415.20 13.75 4001 587962 1135504 108861832
Thrombocytopenia 406.65 13.75 781 591182 348104 109649232
Grip strength decreased 405.28 13.75 1142 590821 79032 109918304
Hypokalaemia 404.47 13.75 237 591726 182211 109815125
Electrocardiogram QT prolonged 400.98 13.75 54 591909 108906 109888430
Nausea 397.90 13.75 4467 587496 1231223 108766113
Arthritis 397.11 13.75 1864 590099 165722 109831614
Cerebrovascular accident 396.94 13.75 239 591724 181045 109816291
Blood pressure systolic abnormal 386.81 13.75 566 591397 24284 109973052
Agitation 377.98 13.75 73 591890 112978 109884358
Knee arthroplasty 376.37 13.75 973 590990 63975 109933361
Metabolic acidosis 375.34 13.75 46 591917 99698 109897638
Urticaria 373.42 13.75 2952 589011 315905 109681431
Off label use 368.53 13.75 10563 581400 1489622 108507714
Cardio-respiratory arrest 364.40 13.75 86 591877 115750 109881586
Lactic acidosis 363.88 13.75 37 591926 92774 109904562
Injury 359.19 13.75 1886 590077 175379 109821957
Dysphagia 358.61 13.75 187 591776 153413 109843923
Skin exfoliation 356.85 13.75 30 591933 87621 109909715
Wound infection 356.13 13.75 1232 590731 95233 109902103
Fall 354.69 13.75 1843 590120 601639 109395697
Joint stiffness 351.88 13.75 970 590993 66273 109931063
Gait inability 350.70 13.75 1554 590409 134822 109862514
Hallucination 346.61 13.75 62 591901 101370 109895966
Night sweats 345.49 13.75 1528 590435 132455 109864881
Dysarthria 336.48 13.75 31 591932 84090 109913246
Hip arthroplasty 335.69 13.75 848 591115 54965 109942371
Breast cancer stage III 335.45 13.75 1059 590904 78058 109919278
Vision blurred 332.27 13.75 137 591826 128885 109868451
International normalised ratio increased 331.50 13.75 38 591925 86734 109910602
Obesity 326.53 13.75 1337 590626 112014 109885322
Balance disorder 324.98 13.75 109 591854 116451 109880885
Osteoporosis 322.53 13.75 1114 590849 86038 109911298
Incorrect dose administered 320.04 13.75 80 591883 103561 109893775
Sleep disorder 319.39 13.75 1987 589976 196657 109800679
Respiratory failure 319.30 13.75 410 591553 214922 109782414
Contusion 318.18 13.75 2240 589723 231121 109766215
Haemoglobin decreased 315.60 13.75 528 591435 248199 109749137
Peripheral venous disease 313.73 13.75 1078 590885 83039 109914297
Deep vein thrombosis postoperative 310.94 13.75 856 591107 58435 109938901
Chest discomfort 309.87 13.75 284 591679 173564 109823772
Sedation 303.60 13.75 17 591946 69666 109927670
Mucosal inflammation 299.22 13.75 73 591890 96068 109901268
Tachycardia 297.97 13.75 470 591493 226175 109771161
Hypercholesterolaemia 297.76 13.75 1116 590847 89721 109907615
Foot deformity 297.23 13.75 742 591221 47738 109949598
Orthostatic hypotension 295.47 13.75 14 591949 66235 109931101
Blood creatinine increased 294.86 13.75 326 591637 182563 109814773
Chronic obstructive pulmonary disease 292.47 13.75 109 591854 109049 109888287
Overdose 291.37 13.75 502 591461 233292 109764044
Hyperglycaemia 288.60 13.75 53 591910 85037 109912299
COVID-19 288.56 13.75 545 591418 244515 109752821
Cognitive disorder 287.33 13.75 59 591904 87452 109909884
Blood pressure systolic increased 286.63 13.75 1037 590926 81954 109915382
Palpitations 286.25 13.75 258 591705 158954 109838382
Pulmonary embolism 285.53 13.75 441 591522 214033 109783303
Drug reaction with eosinophilia and systemic symptoms 283.08 13.75 49 591914 82046 109915290
Lethargy 281.74 13.75 76 591887 93500 109903836
Disability assessment scale score increased 280.86 13.75 211 591752 4059 109993277
Haematochezia 279.66 13.75 134 591829 115390 109881946
Pulmonary fibrosis 277.78 13.75 1183 590780 100859 109896477
Sepsis 277.28 13.75 865 591098 326481 109670855
Cough 276.59 13.75 1400 590563 460241 109537095
Wrong technique in product usage process 276.42 13.75 64 591899 87284 109910052
Mental status changes 274.74 13.75 40 591923 76082 109921254
Ascites 274.52 13.75 78 591885 92730 109904606
Renal impairment 274.05 13.75 364 591599 188081 109809255
Unresponsive to stimuli 273.54 13.75 17 591946 63773 109933563
Serotonin syndrome 272.16 13.75 10 591953 59143 109938193
Suicidal ideation 266.88 13.75 85 591878 93852 109903484
Autoimmune disorder 266.21 13.75 864 591099 64619 109932717
Coronary artery disease 265.03 13.75 35 591928 71655 109925681
Dry skin 265.01 13.75 122 591841 107531 109889805
Myalgia 262.31 13.75 494 591469 221887 109775449
Immunodeficiency 261.15 13.75 616 591347 38222 109959114
Myelosuppression 256.48 13.75 92 591871 94248 109903088
Blood parathyroid hormone decreased 256.19 13.75 333 591630 12756 109984580
Granuloma skin 255.87 13.75 309 591654 10974 109986362
Drug tolerance decreased 255.76 13.75 498 591465 27042 109970294
Pleural effusion 255.63 13.75 346 591617 177363 109819973
Blood glucose increased 255.01 13.75 201 591762 132295 109865041
Disorientation 253.06 13.75 38 591925 70633 109926703
Disturbance in attention 252.97 13.75 21 591942 61974 109935362
Dyspnoea exertional 252.96 13.75 120 591843 103940 109893396
Haematuria 252.58 13.75 66 591897 82939 109914397
Multiple sclerosis relapse 252.50 13.75 3 591960 50237 109947099
Lower limb fracture 251.36 13.75 931 591032 74417 109922919
Onychomadesis 251.20 13.75 671 591292 44992 109952344
Hypomagnesaemia 250.39 13.75 19 591944 60351 109936985
Prescribed overdose 247.45 13.75 1027 590936 86554 109910782
Panniculitis 247.00 13.75 358 591605 15224 109982112
Platelet count decreased 244.56 13.75 544 591419 229899 109767437
Hypoxia 243.61 13.75 201 591762 129314 109868022
Aggression 241.76 13.75 20 591943 59190 109938146
Feeling abnormal 240.12 13.75 372 591591 180339 109816997
Neoplasm progression 240.08 13.75 31 591932 64564 109932772
Plasma cell myeloma 239.31 13.75 28 591935 62908 109934428
Liver disorder 238.78 13.75 1439 590524 140804 109856532
Blood pressure diastolic decreased 237.85 13.75 566 591397 35319 109962017
Vomiting 234.16 13.75 3449 588514 907226 109090110
Restlessness 232.50 13.75 18 591945 56241 109941095
Chills 231.29 13.75 416 591547 190164 109807172
Tubulointerstitial nephritis 231.18 13.75 15 591948 54269 109943067
Diverticulitis 230.16 13.75 720 591243 52802 109944534
Respiratory arrest 229.16 13.75 23 591940 58276 109939060
Adverse event 228.85 13.75 1170 590793 107639 109889697
Pneumonia aspiration 228.13 13.75 75 591888 81158 109916178
Onychomycosis 227.09 13.75 581 591382 37950 109959386
Nail disorder 226.17 13.75 754 591209 57181 109940155
Skin ulcer 224.65 13.75 801 591162 62844 109934492
Angioedema 223.91 13.75 124 591839 98376 109898960
X-ray abnormal 223.86 13.75 574 591389 37543 109959793
Dislocation of vertebra 220.16 13.75 622 591341 43099 109954237
Temperature regulation disorder 220.02 13.75 306 591657 12520 109984816
Generalised tonic-clonic seizure 219.09 13.75 20 591943 54660 109942676
Acute myocardial infarction 218.88 13.75 87 591876 83690 109913646
Toxic epidermal necrolysis 213.81 13.75 26 591937 56701 109940635
Rheumatoid arthritis 212.51 13.75 2496 589467 297117 109700219
Therapeutic product effect incomplete 212.36 13.75 1978 589985 221827 109775509
Urinary tract infection 211.94 13.75 961 591002 325321 109672015
Urinary retention 210.90 13.75 56 591907 69627 109927709
Adjustment disorder with depressed mood 210.02 13.75 613 591350 43270 109954066
Colitis 208.82 13.75 146 591817 102177 109895159
Blood bilirubin increased 204.97 13.75 75 591888 75897 109921439
Pulmonary oedema 204.93 13.75 144 591819 100515 109896821
Dysgeusia 204.81 13.75 60 591903 69925 109927411
Loss of consciousness 203.74 13.75 469 591494 195837 109801499
Hypophagia 201.13 13.75 23 591940 52603 109944733
Blood pressure diastolic increased 196.92 13.75 358 591605 18449 109978887
Blepharospasm 196.74 13.75 694 591269 54157 109943179
Full blood count abnormal 196.48 13.75 32 591931 56020 109941316
Flushing 196.41 13.75 163 591800 104573 109892763
Psychotic disorder 195.33 13.75 22 591941 50915 109946421
Hepatitis 194.75 13.75 976 590987 89078 109908258
Jaundice 192.27 13.75 41 591922 59195 109938141
Hallucination, visual 192.15 13.75 4 591959 39601 109957735
Joint destruction 192.10 13.75 264 591699 10679 109986657
Diabetic ketoacidosis 190.47 13.75 8 591955 42050 109955286
Dyskinesia 190.45 13.75 25 591938 51421 109945915
Accidental overdose 189.95 13.75 26 591937 51808 109945528
Myocardial infarction 189.74 13.75 471 591492 191612 109805724
Melaena 188.70 13.75 66 591897 68691 109928645
Ventricular tachycardia 188.29 13.75 23 591940 49986 109947350
Haematemesis 187.64 13.75 43 591920 59065 109938271
Ear pain 186.25 13.75 668 591295 52558 109944778
Road traffic accident 185.03 13.75 1094 590869 106304 109891032
Cardiogenic shock 183.45 13.75 41 591922 57297 109940039
Drug eruption 183.15 13.75 668 591295 52991 109944345
Drug withdrawal syndrome 180.19 13.75 5 591958 38049 109959287
Blood pressure decreased 180.19 13.75 210 591753 114881 109882455
Chronic kidney disease 179.34 13.75 92 591871 76199 109921137
Obstructive airways disorder 179.33 13.75 19 591944 46130 109951206
Upper gastrointestinal haemorrhage 179.22 13.75 27 591936 50069 109947267
Blood alkaline phosphatase increased 178.33 13.75 78 591885 70857 109926479
Depressed mood 176.36 13.75 53 591910 60756 109936580
Eczema 176.27 13.75 83 591880 72210 109925126
Pulmonary hypertension 175.63 13.75 40 591923 55180 109942156
Liver function test increased 174.38 13.75 935 591028 87613 109909723
C-reactive protein 174.25 13.75 453 591510 29878 109967458
Nightmare 173.99 13.75 8 591955 38855 109958481
Immune effector cell-associated neurotoxicity syndrome 173.69 13.75 296 591667 14486 109982850
Cholestasis 173.54 13.75 64 591899 64454 109932882
Intentional self-injury 173.33 13.75 6 591957 37423 109959913
Transient ischaemic attack 172.89 13.75 63 591900 63919 109933417
Back injury 172.84 13.75 603 591360 46796 109950540
Food allergy 172.34 13.75 350 591613 19598 109977738
Accidental exposure to product 172.07 13.75 30 591933 49978 109947358
Ejection fraction decreased 172.02 13.75 12 591951 40868 109956468
Lung disorder 171.13 13.75 1592 590371 178455 109818881
Arrhythmia 171.00 13.75 79 591884 69496 109927840
Therapeutic response decreased 170.78 13.75 990 590973 95509 109901827
Hypervolaemia 169.47 13.75 30 591933 49430 109947906
Circulatory collapse 168.88 13.75 17 591946 42976 109954360
Haemorrhage 168.84 13.75 193 591770 106499 109890837
Pneumonia 167.60 13.75 3500 588463 873214 109124122
Dry mouth 167.09 13.75 1721 590242 198227 109799109
Asthenia 166.73 13.75 2639 589324 686360 109310976
Blood sodium decreased 164.94 13.75 10 591953 38309 109959027
Blood creatine phosphokinase increased 164.64 13.75 93 591870 72984 109924352
Stevens-Johnson syndrome 163.89 13.75 27 591936 46874 109950462
Bone marrow failure 163.15 13.75 53 591910 57795 109939541
Blood potassium decreased 162.79 13.75 44 591919 54070 109943266
Sinus tachycardia 161.44 13.75 23 591940 44470 109952866
Abdominal pain 161.26 13.75 1862 590101 511127 109486209
Drug level increased 161.22 13.75 30 591933 47689 109949647
Emotional distress 160.83 13.75 24 591939 44823 109952513
Condition aggravated 160.25 13.75 5104 586859 729732 109267604
Irritability 159.52 13.75 31 591932 47778 109949558
Live birth 159.47 13.75 766 591197 68718 109928618
Acute respiratory failure 158.09 13.75 104 591859 75156 109922180
Product prescribing error 157.73 13.75 40 591923 51291 109946045
Finger deformity 157.14 13.75 461 591502 32631 109964705
Dizziness 156.51 13.75 2712 589251 695481 109301855
Exostosis 155.91 13.75 571 591392 45385 109951951
Ventricular fibrillation 155.54 13.75 19 591944 41294 109956042
Encephalopathy 154.65 13.75 124 591839 80931 109916405
Abnormal behaviour 154.49 13.75 15 591948 39024 109958312
Deep vein thrombosis 154.36 13.75 323 591640 139564 109857772
Cerebral haemorrhage 151.74 13.75 79 591884 64889 109932447
Hypophosphataemia 151.31 13.75 6 591957 33176 109964160
Hypoaesthesia 150.96 13.75 2442 589521 311781 109685555
Blood urea increased 150.39 13.75 53 591910 54904 109942432
Neutrophil count decreased 150.32 13.75 260 591703 120681 109876655
Pericardial effusion 150.15 13.75 59 591904 57158 109940178
Anti-cyclic citrullinated peptide antibody 150.12 13.75 331 591632 19633 109977703
Multiple organ dysfunction syndrome 149.82 13.75 372 591591 151338 109845998
Speech disorder 149.63 13.75 71 591892 61498 109935838
Haemoptysis 149.35 13.75 99 591864 71255 109926081
Respiratory distress 147.64 13.75 93 591870 68781 109928555
Hypofibrinogenaemia 147.63 13.75 116 591847 2391 109994945
Rheumatoid factor negative 147.35 13.75 90 591873 1210 109996126
Pyrexia 146.30 13.75 3676 588287 894589 109102747
Injection site erythema 146.18 13.75 173 591790 94003 109903333
Inappropriate antidiuretic hormone secretion 145.20 13.75 9 591954 33842 109963494
Apparent death 144.99 13.75 122 591841 2780 109994556
Hepatic failure 144.37 13.75 95 591868 68644 109928692
Pollakiuria 142.60 13.75 31 591932 44164 109953172
Dysuria 142.52 13.75 72 591891 60159 109937177
Neutropenic sepsis 142.13 13.75 5 591958 30741 109966595
Treatment noncompliance 141.35 13.75 110 591853 72880 109924456
Hemiparesis 141.25 13.75 31 591932 43872 109953464
Myoclonus 140.86 13.75 9 591954 32989 109964347
Rash macular 140.36 13.75 20 591943 38666 109958670
Cardiac disorder 140.22 13.75 121 591842 76159 109921177
Pain in extremity 139.98 13.75 3505 588458 483613 109513723
Presyncope 139.27 13.75 44 591919 48843 109948493
Aphasia 138.89 13.75 71 591892 58926 109938410
Blood calcium decreased 138.67 13.75 15 591948 35830 109961506
Retinitis 137.25 13.75 433 591530 31894 109965442
Poisoning 137.16 13.75 4 591959 29101 109968235
Electrolyte imbalance 137.05 13.75 18 591945 37010 109960326
Lupus vulgaris 136.73 13.75 446 591517 33437 109963899
Altered state of consciousness 136.18 13.75 69 591894 57557 109939779
Polyarthritis 135.42 13.75 308 591655 18655 109978681
Bone pain 134.13 13.75 92 591871 65041 109932295
Skin necrosis 133.69 13.75 331 591632 21181 109976155
Deformity 133.56 13.75 214 591749 9946 109987390
Withdrawal syndrome 132.65 13.75 9 591954 31371 109965965
Investigation abnormal 132.60 13.75 108 591855 2348 109994988
Hypertension 132.58 13.75 3622 588341 506462 109490874
White blood cell count decreased 132.50 13.75 704 591259 228686 109768650
Vertigo 132.26 13.75 162 591801 86708 109910628
Heart rate decreased 131.76 13.75 826 591137 81930 109915406
Maternal exposure timing unspecified 130.25 13.75 323 591640 20690 109976646
Clostridium difficile colitis 127.24 13.75 38 591925 43740 109953596
Anxiety 126.91 13.75 1207 590756 343871 109653465
Product label confusion 126.50 13.75 335 591628 22342 109974994
Therapy non-responder 125.28 13.75 1341 590622 155966 109841370
Osteonecrosis of jaw 125.20 13.75 50 591913 47967 109949369
Intestinal obstruction 122.43 13.75 66 591897 53161 109944175
Lip swelling 122.25 13.75 59 591904 50608 109946728
Small intestinal obstruction 120.82 13.75 15 591948 32198 109965138
Intentional product misuse 119.77 13.75 341 591622 132563 109864773
Dermatitis atopic 118.60 13.75 4 591959 25537 109971799
Cardiomegaly 118.48 13.75 10 591953 29120 109968216
Joint laxity 118.31 13.75 102 591861 2405 109994931
Angina pectoris 117.97 13.75 96 591867 62199 109935137
Pallor 117.29 13.75 79 591884 56388 109940948
Decreased appetite 116.49 13.75 1818 590145 474028 109523308
Joint injury 116.11 13.75 473 591490 39521 109957815
Abdominal pain upper 115.84 13.75 2563 589400 346548 109650788
Lupus-like syndrome 115.71 13.75 479 591484 40313 109957023
Prescribed underdose 115.54 13.75 669 591294 64505 109932831
Haemophagocytic lymphohistiocytosis 115.50 13.75 402 591561 31157 109966179
Ataxia 115.45 13.75 13 591950 30095 109967241
Respiratory depression 115.04 13.75 17 591946 31984 109965352
Haemorrhage intracranial 114.98 13.75 11 591952 28958 109968378
Laryngitis 114.84 13.75 491 591472 41920 109955416
Limb deformity 114.76 13.75 120 591843 3626 109993710
Subdural haematoma 114.75 13.75 27 591936 36427 109960909
Oral mucosal exfoliation 114.68 13.75 84 591879 1552 109995784
Gastritis 114.43 13.75 73 591890 53626 109943710
Human antichimeric antibody positive 114.40 13.75 86 591877 1656 109995680
Muscle rigidity 114.37 13.75 3 591960 24028 109973308
Metastases to bone 114.33 13.75 16 591947 31356 109965980
Gamma-glutamyltransferase increased 114.22 13.75 96 591867 61213 109936123
Troponin increased 113.77 13.75 13 591950 29753 109967583
Blood pressure fluctuation 113.67 13.75 738 591225 74086 109923250
Injection site swelling 113.59 13.75 98 591865 61692 109935644
Tenosynovitis 113.54 13.75 262 591701 16021 109981315
Hallucination, auditory 113.28 13.75 7 591956 26390 109970946
Joint dislocation 112.79 13.75 421 591542 33769 109963567
Influenza like illness 112.69 13.75 187 591776 88225 109909111
Mental disorder 112.15 13.75 34 591929 38757 109958579
Hepatic encephalopathy 111.43 13.75 11 591952 28245 109969091
Joint arthroplasty 111.40 13.75 115 591848 3422 109993914
Dystonia 110.27 13.75 7 591956 25798 109971538
Agranulocytosis 109.87 13.75 101 591862 61659 109935677
Eating disorder 109.54 13.75 17 591946 30841 109966495
Urinary incontinence 109.21 13.75 62 591901 48525 109948811
Transfusion 108.58 13.75 7 591956 25465 109971871
Paraesthesia oral 107.87 13.75 24 591939 33647 109963689
Sinus bradycardia 107.53 13.75 15 591948 29468 109967868
Musculoskeletal deformity 107.20 13.75 79 591884 1474 109995862
Body height below normal 106.99 13.75 89 591874 1995 109995341
Seronegative arthritis 106.56 13.75 225 591738 12952 109984384
General physical health deterioration 105.13 13.75 3001 588962 422294 109575042
Rheumatoid lung 104.40 13.75 122 591841 4182 109993154
Diplopia 103.83 13.75 47 591916 41847 109955489
Disability 102.92 13.75 376 591587 29847 109967489
Muscle twitching 102.90 13.75 18 591945 29917 109967419
Hyperhidrosis 102.57 13.75 585 591378 186713 109810623
Haematocrit decreased 102.02 13.75 122 591841 65995 109931341
Hypothyroidism 101.72 13.75 145 591818 72754 109924582
Faeces discoloured 101.37 13.75 28 591935 33920 109963416
Metastases to central nervous system 101.17 13.75 5 591958 22812 109974524
Infusion site reaction 100.46 13.75 263 591700 17419 109979917
Nephropathy toxic 100.17 13.75 14 591949 27464 109969872
Swollen tongue 100.12 13.75 105 591858 60257 109937079
Drug tolerance 99.71 13.75 252 591711 16333 109981003
Hyperthyroidism 99.70 13.75 18 591945 29243 109968093
Tachypnoea 99.53 13.75 43 591920 39352 109957984
Leukocytosis 99.40 13.75 85 591878 53743 109943593
Pneumonitis 99.29 13.75 160 591803 76371 109920965
Visual acuity reduced 98.99 13.75 25 591938 32148 109965188
Acute myeloid leukaemia 98.85 13.75 40 591923 38070 109959266
Unevaluable event 98.27 13.75 103 591860 59124 109938212
Ileus 98.24 13.75 22 591941 30707 109966629
Haematoma 97.81 13.75 101 591862 58375 109938961
Neck pain 97.72 13.75 1049 590914 122081 109875255
Cardiomyopathy 97.62 13.75 29 591934 33496 109963840
End stage renal disease 97.52 13.75 4 591959 21469 109975867
Oedema peripheral 97.40 13.75 1208 590755 327452 109669884
Anuria 97.25 13.75 9 591954 24332 109973004
Aplastic anaemia 97.09 13.75 9 591954 24299 109973037
Device issue 96.76 13.75 32 591931 34503 109962833
Mitral valve incompetence 96.74 13.75 29 591934 33300 109964036
Injection site reaction 96.69 13.75 811 591152 88259 109909077
Clostridium difficile infection 96.65 13.75 82 591881 52047 109945289
Product administration error 96.64 13.75 39 591924 37178 109960158
Myocardial ischaemia 96.33 13.75 14 591949 26670 109970666
Hypersomnia 96.18 13.75 17 591946 28044 109969292
Schizophrenia 96.08 13.75 5 591958 21821 109975515
Arteriosclerosis coronary artery 95.93 13.75 11 591952 25107 109972229
Sinus disorder 95.86 13.75 28 591935 32700 109964636
Activated partial thromboplastin time prolonged 95.78 13.75 6 591957 22362 109974974
Hyperlipidaemia 95.67 13.75 36 591927 35812 109961524
Pulmonary arterial hypertension 95.14 13.75 28 591935 32540 109964796
Delusion 94.33 13.75 9 591954 23746 109973590
Blood albumin decreased 94.24 13.75 17 591946 27635 109969701
Glomerular filtration rate decreased 94.06 13.75 20 591943 28936 109968400
Bone cyst 93.92 13.75 106 591857 3497 109993839
Blood lactate dehydrogenase increased 93.47 13.75 61 591902 44273 109953063
Transplant rejection 93.22 13.75 11 591952 24556 109972780
Oesophagitis 92.94 13.75 20 591943 28695 109968641
Procedural pain 92.78 13.75 37 591926 35528 109961808
Rash maculo-papular 92.74 13.75 159 591804 74063 109923273
Status epilepticus 92.49 13.75 27 591936 31544 109965792
Tricuspid valve incompetence 92.32 13.75 10 591953 23863 109973473
Hypoalbuminaemia 92.12 13.75 21 591942 28953 109968383
Body temperature decreased 91.96 13.75 417 591546 36518 109960818
Red blood cell sedimentation rate 91.84 13.75 126 591837 5088 109992248
Nodule 91.63 13.75 382 591581 32249 109965087
Coordination abnormal 91.63 13.75 13 591950 25215 109972121
Toxic skin eruption 91.46 13.75 18 591945 27497 109969839
Mania 90.81 13.75 5 591958 20791 109976545
Flatulence 90.75 13.75 87 591876 52062 109945274
Respiratory disorder 90.70 13.75 674 591289 70708 109926628
Hypothermia 90.01 13.75 16 591947 26286 109971050
Coagulopathy 89.41 13.75 54 591909 40857 109956479
Acute generalised exanthematous pustulosis 89.32 13.75 7 591956 21657 109975679
Parkinsonism 89.19 13.75 8 591955 22179 109975157
Torsade de pointes 88.60 13.75 9 591954 22591 109974745
Brain oedema 88.57 13.75 28 591935 31070 109966266
Swelling face 88.33 13.75 230 591733 92091 109905245
Full blood count decreased 87.75 13.75 31 591932 32068 109965268
Mental impairment 86.25 13.75 10 591953 22629 109974707
Eosinophilia 86.14 13.75 110 591853 57826 109939510
Drug level decreased 85.79 13.75 3 591960 18545 109978791
Anal incontinence 85.45 13.75 9 591954 21955 109975381
Paranoia 84.94 13.75 10 591953 22364 109974972
Illness 84.66 13.75 197 591766 81974 109915362
Hepatic cytolysis 84.50 13.75 102 591861 54951 109942385
Renal disorder 84.42 13.75 84 591879 49395 109947941
Aspiration 84.31 13.75 29 591934 30504 109966832
Fear 84.12 13.75 12 591951 23181 109974155
Eye pruritus 84.04 13.75 35 591928 32740 109964596
Rash papular 84.03 13.75 22 591941 27617 109969719
Iron deficiency anaemia 83.71 13.75 32 591931 31527 109965809
Productive cough 82.58 13.75 323 591640 113982 109883354
Musculoskeletal disorder 82.33 13.75 288 591675 22376 109974960
Face oedema 82.25 13.75 38 591925 33431 109963905
Pancreatitis acute 82.02 13.75 122 591841 60152 109937184
Acute coronary syndrome 81.44 13.75 13 591950 23099 109974237
Atrioventricular block complete 81.38 13.75 7 591956 20075 109977261
Acute hepatic failure 81.30 13.75 47 591916 36421 109960915
Left ventricular dysfunction 81.03 13.75 14 591949 23479 109973857
Hepatic cirrhosis 80.58 13.75 629 591334 66997 109930339
Head injury 80.57 13.75 67 591896 42950 109954386
Bronchitis chronic 80.49 13.75 115 591848 4825 109992511
Metastases to liver 79.76 13.75 45 591918 35341 109961995
Surgical failure 79.50 13.75 54 591909 880 109996456
Ventricular extrasystoles 79.18 13.75 13 591950 22628 109974708
Dialysis 79.07 13.75 7 591956 19612 109977724
Malnutrition 78.70 13.75 24 591939 27255 109970081
Arteriosclerosis 78.64 13.75 18 591945 24749 109972587
Miosis 78.28 13.75 12 591951 21971 109975365
Right ventricular failure 78.26 13.75 21 591942 25933 109971403
Tinnitus 78.13 13.75 127 591836 60413 109936923
Adverse reaction 78.12 13.75 340 591623 29254 109968082
Physical disability 77.58 13.75 115 591848 4991 109992345
Epistaxis 77.56 13.75 396 591567 129976 109867360
Hypokinesia 77.53 13.75 12 591951 21814 109975522
Gout 77.51 13.75 50 591913 36516 109960820
Proctitis 77.39 13.75 3 591960 16924 109980412
Immobile 77.34 13.75 144 591819 7558 109989778
Hypocalcaemia 77.20 13.75 145 591818 65221 109932115
Product dose omission in error 76.87 13.75 16 591947 23496 109973840
Adverse drug reaction 76.32 13.75 883 591080 104676 109892660
Dementia 76.23 13.75 37 591926 31636 109965700
Eye swelling 75.97 13.75 41 591922 33007 109964329
Rectal haemorrhage 75.90 13.75 356 591607 119477 109877859
Hemiplegia 75.52 13.75 15 591948 22767 109974569
Shock 75.35 13.75 106 591857 53482 109943854
Female genital tract fistula 75.28 13.75 3 591960 16516 109980820
Ulcer 74.10 13.75 439 591524 42677 109954659
Oral candidiasis 74.08 13.75 78 591885 44682 109952654
Injection site mass 74.06 13.75 20 591943 24593 109972743
Ageusia 74.04 13.75 9 591954 19636 109977700
Cardiotoxicity 73.90 13.75 4 591959 16877 109980459
Cardiac failure acute 73.52 13.75 19 591944 24059 109973277
Cerebral infarction 73.43 13.75 102 591861 51736 109945600
Nervousness 73.32 13.75 54 591909 36797 109960539
Mood altered 73.15 13.75 13 591950 21362 109975974
Drug resistance 72.99 13.75 118 591845 56256 109941080
Cyanosis 72.72 13.75 34 591929 29707 109967629
Radiculopathy 72.53 13.75 9 591954 19327 109978009
Hypovolaemia 72.42 13.75 14 591949 21660 109975676
Hospitalisation 72.24 13.75 456 591507 142037 109855299
Basal cell carcinoma 72.14 13.75 452 591511 44818 109952518
Angina unstable 71.60 13.75 4 591959 16428 109980908
Loose body in joint 71.57 13.75 60 591903 1360 109995976
Hyperphosphataemia 71.34 13.75 4 591959 16377 109980959
Skin haemorrhage 71.34 13.75 22 591941 24805 109972531
Joint effusion 71.12 13.75 260 591703 20645 109976691
Arthrodesis 70.91 13.75 80 591883 2638 109994698
Metastases to lung 70.80 13.75 18 591945 23045 109974291
Infusion site pain 70.79 13.75 6 591957 17413 109979923
Atrial flutter 70.62 13.75 21 591942 24241 109973095
Polyneuropathy 70.31 13.75 42 591921 31970 109965366
Blood glucose decreased 70.14 13.75 35 591928 29453 109967883
Taste disorder 69.71 13.75 593 591370 64794 109932542
Haemodialysis 69.61 13.75 7 591956 17712 109979624
Ear infection 69.58 13.75 574 591389 62158 109935178
Intestinal sepsis 69.14 13.75 51 591912 953 109996383
Device dislocation 69.07 13.75 42 591921 31662 109965674
Thrombosis 68.71 13.75 323 591640 108339 109888997
Renal tubular necrosis 68.33 13.75 39 591924 30436 109966900
Concomitant disease aggravated 68.28 13.75 5 591958 16359 109980977
Salivary hypersecretion 68.13 13.75 7 591956 17414 109979922
Atrioventricular block 68.07 13.75 6 591957 16871 109980465
Vaginal discharge 68.00 13.75 8 591955 17900 109979436
Supraventricular tachycardia 67.77 13.75 23 591940 24399 109972937
Herpes zoster 67.71 13.75 882 591081 107497 109889839
Haematotoxicity 67.59 13.75 15 591948 21067 109976269
Polyuria 67.16 13.75 8 591955 17730 109979606
Renal injury 67.13 13.75 10 591953 18703 109978633
Peripheral sensory neuropathy 67.09 13.75 6 591957 16674 109980662
Lymphocyte count decreased 65.84 13.75 129 591834 57114 109940222
Respiratory tract infection 65.81 13.75 182 591781 71435 109925901
Blood uric acid increased 65.71 13.75 17 591946 21512 109975824
Arthritis bacterial 65.67 13.75 165 591798 10655 109986681
Blood phosphorus increased 65.39 13.75 6 591957 16334 109981002
Atelectasis 65.35 13.75 60 591903 36652 109960684
Tooth disorder 65.32 13.75 322 591641 29187 109968149
Product substitution issue 65.25 13.75 21 591942 23040 109974296
Myocarditis 65.22 13.75 40 591923 30015 109967321
Skin burning sensation 65.17 13.75 18 591945 21807 109975529
Myopathy 65.06 13.75 26 591937 24934 109972402
Second primary malignancy 64.03 13.75 10 591953 18058 109979278
Respiratory symptom 64.02 13.75 4 591959 14941 109982395
Device leakage 63.94 13.75 6 591957 16042 109981294
Lung infiltration 63.63 13.75 26 591937 24602 109972734
Bronchospasm 63.21 13.75 42 591921 30197 109967139
Disease recurrence 63.20 13.75 145 591818 60639 109936697
Graft versus host disease 63.15 13.75 12 591951 18794 109978542
Pregnancy 63.08 13.75 479 591484 50588 109946748
Electrocardiogram abnormal 62.69 13.75 12 591951 18697 109978639
Purpura 62.60 13.75 26 591937 24362 109972974
Macular degeneration 62.58 13.75 19 591944 21640 109975696
Blood magnesium decreased 62.57 13.75 15 591948 19981 109977355
Toxic encephalopathy 62.49 13.75 5 591958 15209 109982127
Venoocclusive liver disease 62.46 13.75 5 591958 15202 109982134
Prothrombin time prolonged 62.44 13.75 9 591954 17252 109980084
Hypotonia 62.43 13.75 6 591957 15739 109981597
Myelodysplastic syndrome 62.40 13.75 65 591898 37419 109959917
Jaundice cholestatic 62.31 13.75 4 591959 14604 109982732
Abortion spontaneous 62.25 13.75 55 591908 34227 109963109
Posterior reversible encephalopathy syndrome 61.88 13.75 54 591909 33807 109963529
Fine motor skill dysfunction 61.38 13.75 116 591847 6158 109991178
Chromaturia 61.08 13.75 41 591922 29319 109968017
Bone density decreased 61.02 13.75 207 591756 15835 109981501
Thirst 61.01 13.75 20 591943 21687 109975649
Impaired quality of life 61.01 13.75 43 591920 29974 109967362
Injection site warmth 60.85 13.75 10 591953 17395 109979941
Pain of skin 60.78 13.75 16 591947 20013 109977323
Myasthenia gravis 60.14 13.75 20 591943 21491 109975845
Walking aid user 60.12 13.75 280 591683 24795 109972541
Porphyria acute 60.08 13.75 229 591734 18551 109978785
Cholelithiasis 59.91 13.75 159 591804 63263 109934073
Nephropathy 59.55 13.75 3 591960 13464 109983872
Shock haemorrhagic 59.49 13.75 36 591927 27211 109970125
Pemphigoid 59.32 13.75 16 591947 19691 109977645
Vaginal haemorrhage 59.28 13.75 30 591933 25044 109972292
Hepatocellular injury 59.22 13.75 113 591850 50529 109946807
Eyelid ptosis 58.83 13.75 3 591960 13324 109984012
Chest pain 58.44 13.75 1550 590413 374825 109622511
Caesarean section 58.30 13.75 4 591959 13813 109983523
Faecaloma 58.28 13.75 6 591957 14902 109982434
Terminal state 58.22 13.75 107 591856 5560 109991776
Forced expiratory volume decreased 58.06 13.75 3 591960 13173 109984163
Localised infection 57.86 13.75 412 591551 42636 109954700
Muscle spasticity 57.48 13.75 359 591604 35556 109961780
Hepatitis cholestatic 57.33 13.75 12 591951 17554 109979782
Subarachnoid haemorrhage 57.20 13.75 45 591918 29657 109967679
Incontinence 57.18 13.75 10 591953 16625 109980711
Presbyacusis 57.17 13.75 73 591890 2746 109994590
Therapeutic response unexpected 57.16 13.75 28 591935 23815 109973521
Dysphonia 57.14 13.75 211 591752 75718 109921618
Epilepsy 57.05 13.75 802 591161 99407 109897929
Gastric disorder 56.91 13.75 339 591624 33018 109964318
Blood iron abnormal 56.83 13.75 54 591909 1450 109995886
Systemic lupus erythematosus rash 56.71 13.75 62 591901 1973 109995363
Eructation 56.69 13.75 5 591958 14052 109983284
Urine output decreased 56.42 13.75 18 591945 19858 109977478
Glycosylated haemoglobin increased 56.23 13.75 28 591935 23591 109973745
Progressive multifocal leukoencephalopathy 55.87 13.75 32 591931 24924 109972412
Haemolytic anaemia 55.84 13.75 21 591942 20899 109976437
Hyperthermia 55.71 13.75 22 591941 21250 109976086
Squamous cell carcinoma of skin 55.64 13.75 12 591951 17191 109980145
Dermatitis acneiform 55.60 13.75 3 591960 12692 109984644
Neutrophil count increased 55.56 13.75 62 591901 34590 109962746
Blood lactic acid increased 55.52 13.75 9 591954 15812 109981524
Limb mass 55.50 13.75 86 591877 3883 109993453
Blood loss anaemia 55.47 13.75 14 591949 18011 109979325
Wheezing 55.46 13.75 1773 590190 253457 109743879
Coronary artery stenosis 55.20 13.75 5 591958 13753 109983583
Dysstasia 55.13 13.75 57 591906 32929 109964407
Exposure during pregnancy 55.09 13.75 1228 590735 166196 109831140
Anticipatory anxiety 55.05 13.75 49 591914 1207 109996129
Atrioventricular block first degree 54.90 13.75 6 591957 14219 109983117
Congestive cardiomyopathy 54.87 13.75 6 591957 14213 109983123
Impaired work ability 54.76 13.75 283 591680 26136 109971200
Device related infection 54.74 13.75 79 591884 39440 109957896
Device occlusion 54.74 13.75 8 591955 15177 109982159
Injection site pruritus 54.33 13.75 121 591842 51137 109946199
Dizziness postural 54.31 13.75 7 591956 14602 109982734
Panic attack 54.29 13.75 45 591918 28895 109968441
Pulmonary alveolar haemorrhage 54.16 13.75 20 591943 20130 109977206
Diastolic dysfunction 54.11 13.75 3 591960 12401 109984935
Haemorrhoids 53.79 13.75 67 591896 35605 109961731
Bundle branch block left 53.60 13.75 4 591959 12884 109984452
Sudden death 53.59 13.75 32 591931 24363 109972973
Acute graft versus host disease 53.57 13.75 4 591959 12877 109984459
Respiratory acidosis 52.94 13.75 6 591957 13820 109983516
Skin discolouration 52.63 13.75 115 591848 48931 109948405
Proteinuria 52.53 13.75 83 591880 39935 109957401
Motor dysfunction 52.24 13.75 33 591930 24373 109972963
Therapeutic response shortened 51.89 13.75 49 591914 29534 109967802
Sensory loss 51.74 13.75 25 591938 21432 109975904
Device difficult to use 51.68 13.75 18 591945 18787 109978549
Anosmia 51.50 13.75 4 591959 12468 109984868
Thrombotic microangiopathy 51.45 13.75 48 591915 29101 109968235
Appendicitis 51.28 13.75 46 591917 28418 109968918
Escherichia infection 51.26 13.75 32 591931 23784 109973552
Injection site haemorrhage 50.89 13.75 61 591902 32967 109964369
Antibody test positive 49.91 13.75 72 591891 3048 109994288
Nystagmus 49.89 13.75 3 591960 11574 109985762
Multiple fractures 49.79 13.75 132 591831 8808 109988528
Rhinorrhoea 49.77 13.75 333 591630 102333 109895003
Gastric haemorrhage 49.68 13.75 12 591951 15903 109981433
Odynophagia 49.53 13.75 8 591955 14093 109983243
Prostate cancer 49.48 13.75 78 591885 37563 109959773
Oliguria 49.34 13.75 19 591944 18638 109978698
Ischaemic stroke 49.20 13.75 91 591872 41172 109956164
Normochromic normocytic anaemia 49.16 13.75 6 591957 13051 109984285
Diabetes mellitus inadequate control 49.15 13.75 52 591911 29723 109967613
Hypoacusis 49.09 13.75 70 591893 35121 109962215
Kidney transplant rejection 49.07 13.75 4 591959 11983 109985353
Electrocardiogram QRS complex prolonged 48.99 13.75 6 591957 13015 109984321
Short stature 48.83 13.75 43 591920 1044 109996292
Immune thrombocytopenia 48.72 13.75 30 591933 22464 109974872
Abdominal distension 48.72 13.75 652 591311 174451 109822885
Ankle arthroplasty 48.52 13.75 64 591899 2487 109994849
Nervous system disorder 48.44 13.75 59 591904 31662 109965674
Chronic sinusitis 48.31 13.75 38 591925 25046 109972290
Cold sweat 48.25 13.75 29 591934 22002 109975334
Rales 48.25 13.75 37 591926 24702 109972634
Generalised oedema 48.07 13.75 56 591907 30648 109966688
Mesenteritis 47.94 13.75 28 591935 345 109996991
Complication associated with device 47.48 13.75 24 591939 20049 109977287
Breast cancer stage II 47.21 13.75 279 591684 27096 109970240
Acute pulmonary oedema 47.17 13.75 16 591947 16980 109980356
Personality change 46.96 13.75 3 591960 10999 109986337
Premature delivery 46.75 13.75 57 591906 30575 109966761
Erythema 46.61 13.75 1195 590768 290252 109707084
Petechiae 46.60 13.75 34 591929 23283 109974053
Oral herpes 46.58 13.75 342 591621 35738 109961598
Staphylococcal infection 46.55 13.75 204 591759 69740 109927596
Osteoporotic fracture 46.53 13.75 94 591869 5243 109992093
Red blood cell count decreased 46.52 13.75 188 591775 65735 109931601
Spondylitis 46.43 13.75 150 591813 11188 109986148
Product preparation error 46.34 13.75 3 591960 10876 109986460
Hospice care 46.31 13.75 6 591957 12467 109984869
Lower respiratory tract congestion 46.09 13.75 88 591875 4708 109992628
Anger 46.06 13.75 22 591941 18985 109978351
Pharyngitis 46.03 13.75 260 591703 24838 109972498
Erythema multiforme 45.89 13.75 28 591935 21069 109976267
Dermatitis exfoliative 45.86 13.75 4 591959 11343 109985993
Urosepsis 45.85 13.75 58 591905 30617 109966719
Asphyxia 45.80 13.75 10 591953 14205 109983131
Lacrimation increased 45.76 13.75 59 591904 30891 109966445
Synovial cyst 45.71 13.75 150 591813 11280 109986056
Hyperammonaemia 45.61 13.75 9 591954 13723 109983613
Stress cardiomyopathy 45.43 13.75 14 591949 15792 109981544
Product prescribing issue 45.42 13.75 7 591956 12765 109984571
Squamous cell carcinoma 45.31 13.75 21 591942 18442 109978894
Coronary artery occlusion 45.27 13.75 14 591949 15758 109981578
Device malfunction 45.22 13.75 42 591921 25516 109971820
Parosmia 45.14 13.75 8 591955 13172 109984164
Lymphadenopathy 45.07 13.75 182 591781 63653 109933683
Vascular device infection 45.04 13.75 16 591947 16496 109980840
Dyspepsia 44.77 13.75 1339 590624 189626 109807710
Autoimmune haemolytic anaemia 44.76 13.75 3 591960 10564 109986772
Aortic stenosis 44.56 13.75 8 591955 13051 109984285
Juvenile idiopathic arthritis 44.49 13.75 99 591864 5908 109991428
Micturition urgency 44.37 13.75 24 591939 19296 109978040
Exercise tolerance decreased 44.34 13.75 6 591957 12061 109985275
Poor quality sleep 44.18 13.75 51 591912 28026 109969310
Prostatic specific antigen increased 44.16 13.75 7 591956 12504 109984832
Lower gastrointestinal haemorrhage 43.88 13.75 22 591941 18464 109978872
Glaucoma 43.79 13.75 237 591726 22280 109975056
Hyperbilirubinaemia 43.79 13.75 60 591903 30611 109966725
Hypopnoea 43.42 13.75 5 591958 11375 109985961
Insomnia 43.41 13.75 2353 589610 358237 109639099
Muscle atrophy 43.37 13.75 9 591954 13245 109984091
Left ventricular hypertrophy 43.32 13.75 9 591954 13235 109984101
Soft tissue disorder 43.31 13.75 72 591891 3452 109993884
Lipase increased 43.16 13.75 23 591940 18649 109978687
Blood pressure abnormal 43.15 13.75 34 591929 22390 109974946
Pulmonary haemorrhage 43.12 13.75 17 591946 16439 109980897
Rhinitis allergic 43.04 13.75 21 591942 17901 109979435
Catatonia 43.02 13.75 5 591958 11295 109986041
Cardiac murmur 42.95 13.75 41 591922 24587 109972749
Gangrene 42.63 13.75 17 591946 16324 109981012
Dermatitis contact 42.62 13.75 11 591952 13942 109983394
Sleep apnoea syndrome 42.44 13.75 96 591867 40351 109956985
Haemodynamic instability 42.43 13.75 36 591927 22852 109974484
Toothache 42.43 13.75 243 591720 23332 109974004
Post procedural complication 42.41 13.75 48 591915 26610 109970726
Osteonecrosis 42.40 13.75 72 591891 33669 109963667
Azotaemia 42.32 13.75 3 591960 10082 109987254
Sneezing 42.30 13.75 66 591897 31918 109965418
Cerebral ischaemia 42.22 13.75 7 591956 12097 109985239
Nephrotic syndrome 42.07 13.75 11 591952 13820 109983516
Pathogen resistance 41.99 13.75 21 591942 17651 109979685
Cardiac failure chronic 41.97 13.75 11 591952 13800 109983536
Wheelchair user 41.88 13.75 114 591849 7728 109989608
Retinal toxicity 41.88 13.75 48 591915 1611 109995725
Viral infection 41.76 13.75 145 591818 52994 109944342
Demyelination 41.60 13.75 128 591835 9301 109988035
Blood triglycerides increased 41.53 13.75 40 591923 23886 109973450
Infusion site erythema 41.53 13.75 7 591956 11952 109985384
Hepatic necrosis 41.49 13.75 3 591960 9919 109987417
Neurotoxicity 41.25 13.75 104 591859 42103 109955233
Therapy cessation 41.21 13.75 114 591849 44743 109952593
Paralysis 41.07 13.75 16 591947 15584 109981752
Respiration abnormal 40.92 13.75 3 591960 9806 109987530
Bacterial infection 40.81 13.75 119 591844 45917 109951419
Foetal death 40.57 13.75 182 591781 15863 109981473
Back pain 40.53 13.75 1599 590364 369397 109627939
Brain injury 40.45 13.75 11 591952 13465 109983871
Eosinophil count increased 40.43 13.75 32 591931 21026 109976310
Abnormal loss of weight 40.43 13.75 4 591959 10253 109987083
Immunosuppressant drug level increased 40.41 13.75 7 591956 11717 109985619
Tumour lysis syndrome 40.32 13.75 64 591899 30737 109966599
Metastases to lymph nodes 40.27 13.75 15 591948 15017 109982319
Injection site urticaria 40.10 13.75 21 591942 17194 109980142
Eosinophilic granulomatosis with polyangiitis 40.02 13.75 5 591958 10681 109986655
Arterial occlusive disease 39.81 13.75 16 591947 15292 109982044
Aplasia pure red cell 39.76 13.75 3 591960 9575 109987761
Mood swings 39.76 13.75 38 591925 22774 109974562
Diverticular perforation 39.64 13.75 98 591865 6264 109991072
Iron deficiency 39.52 13.75 25 591938 18451 109978885
Enteritis 39.51 13.75 27 591936 19129 109978207
Nail operation 39.40 13.75 47 591916 1647 109995689
Colitis microscopic 39.34 13.75 159 591804 13235 109984101
Cytology abnormal 39.33 13.75 24 591939 322 109997014
Gynaecomastia 39.31 13.75 3 591960 9487 109987849
Proctalgia 39.30 13.75 11 591952 13211 109984125
Orthopnoea 39.28 13.75 6 591957 11015 109986321
Central nervous system lesion 39.25 13.75 17 591946 15536 109981800
Femur fracture 39.14 13.75 387 591576 44082 109953254
Gastric ulcer 39.03 13.75 98 591865 39729 109957607
Multiple sclerosis 39.03 13.75 48 591915 25650 109971686
Pleural fibrosis 38.90 13.75 77 591886 4231 109993105
Injection site bruising 38.87 13.75 142 591821 51121 109946215
Migraine 38.74 13.75 1198 590765 170454 109826882
Sputum discoloured 38.57 13.75 56 591907 27889 109969447
Vascular access complication 38.50 13.75 57 591906 2471 109994865
Cachexia 38.32 13.75 11 591952 12994 109984342
Neuralgia 38.28 13.75 132 591831 48346 109948990
Post transplant lymphoproliferative disorder 37.94 13.75 18 591945 15595 109981741
Muscle abscess 37.92 13.75 43 591920 1426 109995910
Eye movement disorder 37.81 13.75 4 591959 9724 109987612
Hypoaesthesia oral 37.77 13.75 22 591941 16980 109980356
Drug specific antibody 37.77 13.75 60 591903 2768 109994568
Red cell distribution width decreased 37.74 13.75 53 591910 2188 109995148
Hypercapnia 37.73 13.75 7 591956 11152 109986184
Anaphylactic shock 37.64 13.75 145 591818 51401 109945935
Spinal column injury 37.59 13.75 54 591909 2277 109995059
Post procedural haemorrhage 37.52 13.75 18 591945 15494 109981842
Gastrointestinal procedural complication 37.49 13.75 26 591937 439 109996897
Body temperature increased 37.48 13.75 453 591510 54260 109943076
Blood potassium increased 37.32 13.75 76 591887 33173 109964163
Failure to thrive 37.29 13.75 13 591950 13561 109983775
Tension headache 37.27 13.75 4 591959 9614 109987722
Dermatitis bullous 37.11 13.75 24 591939 17505 109979831
Bundle branch block right 36.96 13.75 10 591953 12281 109985055
Alanine aminotransferase abnormal 36.88 13.75 122 591841 9212 109988124
Perineal rash 36.74 13.75 15 591948 77 109997259
Swollen joint count 36.65 13.75 116 591847 8558 109988778
Hyperreflexia 36.61 13.75 4 591959 9481 109987855
Throat tightness 36.36 13.75 78 591885 33411 109963925
Ileus paralytic 36.34 13.75 9 591954 11728 109985608
Oxygen saturation decreased 36.33 13.75 1099 590864 155883 109841453
Amylase increased 36.14 13.75 11 591952 12508 109984828
Joint lock 35.92 13.75 67 591896 3521 109993815
Splenomegaly 35.91 13.75 47 591916 24451 109972885
Breast cancer female 35.91 13.75 11 591952 12457 109984879
Bacteraemia 35.84 13.75 112 591851 42278 109955058
Euglycaemic diabetic ketoacidosis 35.82 13.75 9 591954 11614 109985722
Needle issue 35.67 13.75 26 591937 17814 109979522
Defaecation urgency 35.58 13.75 3 591960 8744 109988592
Blood creatine increased 35.35 13.75 9 591954 11512 109985824
Periorbital oedema 35.31 13.75 6 591957 10186 109987150
Metabolic encephalopathy 35.19 13.75 8 591955 11052 109986284
Blood urine present 35.05 13.75 47 591916 24198 109973138
Electrocardiogram ST segment elevation 35.01 13.75 4 591959 9156 109988180
Neurological symptom 34.96 13.75 20 591943 15588 109981748
Cerebral haematoma 34.89 13.75 5 591958 9627 109987709
Mean platelet volume decreased 34.78 13.75 63 591900 3237 109994099
Joint ankylosis 34.77 13.75 54 591909 2443 109994893
Skin lesion 34.72 13.75 150 591813 51481 109945855
Apathy 34.70 13.75 22 591941 16217 109981119
Pleural thickening 34.69 13.75 64 591899 3335 109994001
Immune reconstitution inflammatory syndrome 34.65 13.75 22 591941 16204 109981132
Aortic arteriosclerosis 34.63 13.75 8 591955 10930 109986406
Hepatitis C 34.61 13.75 12 591951 12561 109984775
Carotid artery occlusion 34.57 13.75 5 591958 9560 109987776
Partial seizures 34.57 13.75 9 591954 11340 109985996
Blood glucose abnormal 34.42 13.75 13 591950 12903 109984433
Choking 34.36 13.75 19 591944 15091 109982245
Hepatitis B virus test positive 34.26 13.75 26 591937 508 109996828
Cholecystitis chronic 34.26 13.75 5 591958 9495 109987841
Lymphopenia 34.06 13.75 106 591857 40064 109957272
Lumbosacral plexopathy 33.90 13.75 15 591948 97 109997239
Infusion site swelling 33.82 13.75 6 591957 9871 109987465
Feeling cold 33.80 13.75 83 591880 33904 109963432
Ocular hyperaemia 33.78 13.75 103 591860 39183 109958153
Cytomegalovirus infection 33.73 13.75 163 591800 54281 109943055
Pulmonary congestion 33.73 13.75 72 591891 30894 109966442
Eyelid oedema 33.55 13.75 20 591943 15242 109982094
Transplant dysfunction 33.48 13.75 3 591960 8325 109989011
Infiltration anaesthesia 33.31 13.75 17 591946 157 109997179
Acidosis 33.26 13.75 43 591920 22488 109974848
Insurance issue 33.13 13.75 8 591955 10604 109986732
Escherichia urinary tract infection 33.05 13.75 23 591940 16139 109981197
Cystitis haemorrhagic 33.02 13.75 12 591951 12197 109985139
Peritonitis bacterial 32.76 13.75 8 591955 10525 109986811
Apnoea 32.72 13.75 16 591947 13623 109983713
Ulcer haemorrhage 32.68 13.75 220 591743 22351 109974985
Pulmonary thrombosis 32.65 13.75 154 591809 13709 109983627
Facial pain 32.48 13.75 21 591942 15318 109982018
Fistula 32.32 13.75 21 591942 15278 109982058
Duodenal ulcer 32.30 13.75 34 591929 19480 109977856
Therapy change 32.28 13.75 7 591956 9990 109987346
Affective disorder 32.23 13.75 10 591953 11231 109986105
Bone swelling 32.07 13.75 44 591919 1777 109995559
Breast cancer metastatic 31.96 13.75 10 591953 11171 109986165
Cellulitis 31.94 13.75 478 591485 125538 109871798
Hiatus hernia 31.93 13.75 62 591901 27544 109969792
Bronchiectasis 31.87 13.75 95 591868 36398 109960938
Bladder cancer 31.78 13.75 37 591926 20255 109977081
Anal fissure 31.74 13.75 7 591956 9874 109987462
Infected bite 31.74 13.75 47 591916 2038 109995298
Pruritus allergic 31.57 13.75 42 591921 1646 109995690
Glucose tolerance impaired 31.53 13.75 7 591956 9830 109987506
Nasal congestion 31.47 13.75 355 591608 97927 109899409
Restless legs syndrome 31.45 13.75 52 591911 24574 109972762
Viral upper respiratory tract infection 31.45 13.75 123 591840 10085 109987251
Skin irritation 31.08 13.75 25 591938 16294 109981042
Benign prostatic hyperplasia 31.05 13.75 31 591932 18203 109979133
Expired product administered 30.90 13.75 4 591959 8316 109989020
Extrasystoles 30.89 13.75 4 591959 8314 109989022
Exposure via skin contact 30.68 13.75 16 591947 13131 109984205
Burns second degree 30.52 13.75 3 591960 7730 109989606
Respiratory syncytial virus infection 30.43 13.75 20 591943 14464 109982872
Colitis ischaemic 30.43 13.75 30 591933 17720 109979616
Granulocytopenia 30.38 13.75 15 591948 12700 109984636
Autoimmune hepatitis 30.36 13.75 21 591942 14783 109982553
Bunion operation 30.34 13.75 31 591932 911 109996425
Arteriospasm coronary 30.15 13.75 6 591957 9094 109988242
Cerebral atrophy 30.08 13.75 6 591957 9079 109988257
Leukopenia 30.07 13.75 588 591375 148203 109849133
Transaminases increased 30.03 13.75 207 591756 63183 109934153
Retinal haemorrhage 29.98 13.75 7 591956 9494 109987842
Refusal of treatment by patient 29.95 13.75 7 591956 9487 109987849
Protein urine present 29.87 13.75 12 591951 11472 109985864
Skin papilloma 29.85 13.75 93 591870 6803 109990533
Acute respiratory distress syndrome 29.73 13.75 165 591798 53033 109944303
Bipolar disorder 29.71 13.75 6 591957 9001 109988335
Grip strength 29.68 13.75 112 591851 9029 109988307
Petit mal epilepsy 29.60 13.75 3 591960 7544 109989792
Product storage error 29.54 13.75 44 591919 21684 109975652
Left ventricular failure 29.46 13.75 12 591951 11377 109985959
Growth retardation 29.41 13.75 51 591912 2531 109994805
Middle insomnia 29.38 13.75 40 591923 20462 109976874
Dermatitis exfoliative generalised 29.31 13.75 11 591952 10961 109986375
Blood immunoglobulin E increased 29.28 13.75 3 591960 7479 109989857
Wrong product administered 29.26 13.75 11 591952 10949 109986387
Stress 29.03 13.75 393 591570 104955 109892381
Metabolic disorder 28.99 13.75 10 591953 10500 109986836
Vasculitic rash 28.93 13.75 47 591916 2210 109995126
Lung consolidation 28.84 13.75 10 591953 10466 109986870
Product availability issue 28.81 13.75 4 591959 7886 109989450
Systemic inflammatory response syndrome 28.80 13.75 17 591946 13026 109984310
Nocturia 28.80 13.75 29 591934 16961 109980375
Abnormal faeces 28.76 13.75 7 591956 9229 109988107
Aplasia 28.73 13.75 4 591959 7869 109989467
Flank pain 28.48 13.75 50 591913 23080 109974256
Oedema 28.47 13.75 1386 590577 208590 109788746
Hyperlactacidaemia 28.44 13.75 5 591958 8281 109989055
Foot operation 28.38 13.75 95 591868 7218 109990118
Clonus 28.35 13.75 6 591957 8710 109988626
Blood magnesium increased 28.31 13.75 63 591900 3760 109993576
Skin hyperpigmentation 28.26 13.75 6 591957 8690 109988646
Hypovolaemic shock 28.20 13.75 22 591941 14561 109982775
Prosthesis user 28.14 13.75 12 591951 70 109997266
Eosinophilic pneumonia 28.02 13.75 3 591960 7224 109990112
Product quality issue 28.00 13.75 575 591388 76724 109920612
Hyperuricaemia 28.00 13.75 22 591941 14509 109982827
Varices oesophageal 27.96 13.75 3 591960 7212 109990124
Pulseless electrical activity 27.96 13.75 29 591934 16728 109980608
Hepatocellular carcinoma 27.95 13.75 9 591954 9871 109987465
Fatigue 27.80 13.75 7116 584847 1208842 108788494
Blood phosphorus decreased 27.72 13.75 4 591959 7661 109989675
Decreased activity 27.69 13.75 12 591951 10962 109986374
Arthritis infective 27.66 13.75 120 591843 10309 109987027
Wrist deformity 27.60 13.75 56 591907 3133 109994203
Thrombotic thrombocytopenic purpura 27.44 13.75 3 591960 7108 109990228
Protein total decreased 27.33 13.75 12 591951 10878 109986458
Ventricular hypertrophy 27.12 13.75 3 591960 7042 109990294
Complication of device insertion 26.93 13.75 7 591956 8831 109988505
Femoral neck fracture 26.89 13.75 17 591946 12550 109984786
Hot flush 26.86 13.75 225 591738 65811 109931525
Thinking abnormal 26.64 13.75 25 591938 15115 109982221
Mass 26.45 13.75 188 591775 19442 109977894
Cholangitis 26.44 13.75 29 591934 16306 109981030
Hypernatraemia 26.36 13.75 34 591929 17799 109979537
Device breakage 26.34 13.75 21 591942 13748 109983588
Metastasis 26.26 13.75 6 591957 8261 109989075
Major depression 26.19 13.75 12 591951 10609 109986727
Ammonia increased 26.19 13.75 6 591957 8244 109989092
Vasculitis 26.14 13.75 101 591862 35772 109961564
Cutaneous vasculitis 26.14 13.75 136 591827 12593 109984743
Enterocolitis 26.13 13.75 38 591925 18911 109978425
Thermal burn 26.04 13.75 98 591865 7890 109989446
Intercepted product preparation error 26.01 13.75 3 591960 6817 109990519
Incorrect dose administered by device 25.98 13.75 3 591960 6811 109990525
Injection site rash 25.88 13.75 54 591909 23365 109973971
Abdominal pain lower 25.88 13.75 107 591856 37176 109960160
Escherichia bacteraemia 25.82 13.75 11 591952 10153 109987183
Cancer pain 25.78 13.75 3 591960 6769 109990567
Transaminases abnormal 25.64 13.75 29 591934 959 109996377
Blood fibrinogen decreased 25.60 13.75 49 591914 2626 109994710
Gastric ulcer haemorrhage 25.52 13.75 11 591952 10083 109987253
Oesophageal candidiasis 25.52 13.75 15 591948 11519 109985817
Oesophageal carcinoma 25.48 13.75 15 591948 11509 109985827
Immune-mediated hepatitis 25.48 13.75 3 591960 6708 109990628
White blood cell count increased 25.35 13.75 365 591598 96477 109900859
Dental restoration failure 25.34 13.75 31 591932 1116 109996220
Duodenal ulcer haemorrhage 25.20 13.75 6 591957 8031 109989305
Rhinovirus infection 25.15 13.75 16 591947 11773 109985563
Duodenitis 24.93 13.75 9 591954 9187 109988149
Sensation of foreign body 24.92 13.75 6 591957 7969 109989367
Oesophageal ulcer 24.87 13.75 6 591957 7958 109989378
Brachiocephalic artery stenosis 24.86 13.75 9 591954 31 109997305
Hepatomegaly 24.85 13.75 48 591915 21366 109975970
Premature labour 24.83 13.75 9 591954 9163 109988173
Brain death 24.80 13.75 3 591960 6570 109990766
Subdural haemorrhage 24.73 13.75 3 591960 6555 109990781
Cardiovascular disorder 24.72 13.75 53 591910 22707 109974629
Embolic stroke 24.67 13.75 8 591955 8735 109988601
Hypertensive crisis 24.65 13.75 59 591904 24313 109973023
Gastritis erosive 24.64 13.75 17 591946 11983 109985353
Injection site hypersensitivity 24.56 13.75 46 591917 2425 109994911
Renal cyst 24.51 13.75 37 591926 18135 109979201
Blood thyroid stimulating hormone increased 24.50 13.75 18 591945 12283 109985053
Pulmonary function test decreased 24.48 13.75 8 591955 8692 109988644
Occult blood positive 24.47 13.75 5 591958 7440 109989896
Fracture delayed union 24.45 13.75 43 591920 2158 109995178
Extremity contracture 24.40 13.75 38 591925 1723 109995613
Pustular psoriasis 24.33 13.75 140 591823 13465 109983871
Blood disorder 24.32 13.75 11 591952 9799 109987537
Product use in unapproved indication 24.21 13.75 2063 589900 445314 109552022
Aspartate aminotransferase increased 24.18 13.75 661 591302 159275 109838061
Mouth swelling 24.05 13.75 5 591958 7349 109989987
Urine analysis abnormal 24.03 13.75 4 591959 6893 109990443
Eye pain 24.03 13.75 163 591800 49936 109947400
Neoscytalidium infection 23.97 13.75 8 591955 20 109997316
Pulmonary toxicity 23.94 13.75 170 591793 17576 109979760
Drug effect less than expected 23.89 13.75 5 591958 7315 109990021
Blood folate decreased 23.88 13.75 44 591919 2291 109995045
BK virus infection 23.83 13.75 21 591942 13085 109984251
Skin reaction 23.73 13.75 194 591769 20950 109976386
Dermatitis allergic 23.67 13.75 198 591765 21526 109975810
Injection site induration 23.54 13.75 16 591947 11367 109985969
Pneumonia viral 23.46 13.75 120 591843 11037 109986299
Areflexia 23.42 13.75 4 591959 6765 109990571
Hypoxic-ischaemic encephalopathy 23.41 13.75 9 591954 8838 109988498
Hydronephrosis 23.39 13.75 47 591916 20618 109976718
Rib fracture 23.39 13.75 97 591866 33673 109963663
Platelet count abnormal 23.38 13.75 3 591960 6279 109991057
Subcutaneous drug absorption impaired 23.36 13.75 92 591871 7567 109989769
Device failure 23.36 13.75 5 591958 7202 109990134
Product administered to patient of inappropriate age 23.31 13.75 7 591956 8029 109989307
Skin plaque 23.31 13.75 20 591943 12625 109984711
Foot fracture 23.30 13.75 224 591739 25322 109972014
Cardiac tamponade 23.24 13.75 16 591947 11291 109986045
Faecal calprotectin increased 23.18 13.75 4 591959 6715 109990621
Catheter site infection 23.15 13.75 7 591956 7993 109989343
Vascular rupture 23.07 13.75 38 591925 1808 109995528
Bone disorder 23.01 13.75 193 591770 20999 109976337
Coagulation factor XIII level decreased 23.00 13.75 6 591957 3 109997333
Haemolysis 22.93 13.75 30 591933 15609 109981727
Pre-eclampsia 22.56 13.75 9 591954 8641 109988695
Tongue oedema 22.52 13.75 8 591955 8248 109989088
Portal hypertension 22.51 13.75 9 591954 8628 109988708
Skin laceration 22.48 13.75 278 591685 33475 109963861
Retinal detachment 22.43 13.75 16 591947 11084 109986252
Renal tubular disorder 22.42 13.75 6 591957 7423 109989913
Hydrocephalus 22.25 13.75 14 591949 10361 109986975
Vascular stenosis 22.20 13.75 24 591939 754 109996582
Neutrophilia 22.06 13.75 14 591949 10315 109987021
Intervertebral disc compression 22 13.75 32 591931 1365 109995971
Hepatitis B 21.98 13.75 12 591951 9600 109987736
Pigmentation disorder 21.88 13.75 6 591957 7305 109990031
Localised oedema 21.85 13.75 11 591952 9212 109988124
Cytokine storm 21.84 13.75 33 591930 1457 109995879
Supraventricular extrasystoles 21.72 13.75 8 591955 8065 109989271
Neutropenic colitis 21.69 13.75 8 591955 8057 109989279
Uterine perforation 21.66 13.75 5 591958 6835 109990501
Body height decreased 21.64 13.75 15 591948 10548 109986788
Methaemoglobinaemia 21.63 13.75 11 591952 9157 109988179
Impaired driving ability 21.53 13.75 4 591959 6366 109990970
Abortion induced 21.49 13.75 8 591955 8011 109989325
Lymphocyte adoptive therapy 21.48 13.75 12 591951 135 109997201
Tooth infection 21.36 13.75 197 591766 22019 109975317
Bedridden 21.36 13.75 134 591829 13291 109984045
Pancreatitis 21.29 13.75 362 591601 93171 109904165
Renal cancer 21.25 13.75 23 591940 13011 109984325
Lichenoid keratosis 21.21 13.75 4 591959 6298 109991038
Rash morbilliform 21.19 13.75 8 591955 7943 109989393
Embolism 21.18 13.75 34 591929 16255 109981081
Musculoskeletal chest pain 21.16 13.75 81 591882 28766 109968570
Large intestine polyp 21.15 13.75 30 591933 15087 109982249
Heparin-induced thrombocytopenia 21.14 13.75 18 591945 11406 109985930
Non-small cell lung cancer 21.12 13.75 8 591955 7927 109989409
Cytomegalovirus chorioretinitis 21.06 13.75 6 591957 7122 109990214
Leukaemia 21 13.75 7 591956 7511 109989825
Total lung capacity decreased 20.99 13.75 6 591957 7108 109990228
Peripheral ischaemia 20.98 13.75 17 591946 11041 109986295
Diarrhoea haemorrhagic 20.94 13.75 32 591931 15607 109981729
Cardiac flutter 20.83 13.75 3 591960 5754 109991582
Eye irritation 20.81 13.75 100 591863 33352 109963984
Lung opacity 20.79 13.75 19 591944 11633 109985703
Adenovirus infection 20.74 13.75 17 591946 10977 109986359
Essential hypertension 20.74 13.75 8 591955 7839 109989497
High density lipoprotein decreased 20.71 13.75 3 591960 5730 109991606
Renal function test abnormal 20.71 13.75 11 591952 8935 109988401
Aortic valve incompetence 20.69 13.75 17 591946 10964 109986372
Haemorrhagic stroke 20.68 13.75 26 591937 13763 109983573
Respiratory alkalosis 20.66 13.75 3 591960 5718 109991618
Pulse absent 20.64 13.75 18 591945 11274 109986062
Carotid artery stenosis 20.56 13.75 12 591951 9251 109988085
Actinic keratosis 20.54 13.75 6 591957 7007 109990329
Gestational diabetes 20.43 13.75 7 591956 7382 109989954
Diabetes insipidus 20.42 13.75 5 591958 6565 109990771
Suture rupture 20.35 13.75 22 591941 691 109996645
N-terminal prohormone brain natriuretic peptide increased 20.35 13.75 4 591959 6117 109991219
Tympanic membrane perforation 20.34 13.75 39 591924 2093 109995243
Mean cell volume decreased 20.32 13.75 72 591891 5630 109991706
Infectious pleural effusion 20.29 13.75 65 591898 4826 109992510
Tuberculin test positive 20.27 13.75 54 591909 3614 109993722
Conjunctivitis allergic 20.17 13.75 6 591957 6925 109990411
Disability assessment scale score decreased 19.96 13.75 6 591957 9 109997327
Papule 19.96 13.75 15 591948 10118 109987218
Normocytic anaemia 19.94 13.75 5 591958 6462 109990874
Vascular access site pain 19.93 13.75 20 591943 575 109996761
Genital haemorrhage 19.83 13.75 7 591956 7245 109990091
Subileus 19.81 13.75 5 591958 6432 109990904
Acute graft versus host disease in skin 19.78 13.75 17 591946 10723 109986613
Laryngeal pain 19.67 13.75 4 591959 5971 109991365
Enthesopathy 19.51 13.75 124 591839 12354 109984982
Overlap syndrome 19.45 13.75 98 591865 8961 109988375
Oropharyngeal discomfort 19.44 13.75 16 591947 10311 109987025
Sensory disturbance 19.42 13.75 40 591923 17389 109979947
Frequent bowel movements 19.42 13.75 267 591696 71123 109926213
Aortic valve stenosis 19.41 13.75 5 591958 6345 109990991
Blood culture positive 19.40 13.75 12 591951 8964 109988372
Cardiopulmonary failure 19.38 13.75 9 591954 7894 109989442
Stupor 19.37 13.75 10 591953 8255 109989081
Foetal exposure during pregnancy 19.26 13.75 8 591955 7497 109989839
Hypercalcaemia 19.25 13.75 354 591609 46303 109951033
Sleep disorder due to a general medical condition 19.24 13.75 182 591781 51930 109945406
Catheter site haemorrhage 19.22 13.75 4 591959 5876 109991460
Therapy interrupted 19.18 13.75 374 591589 49448 109947888
Hip fracture 19.11 13.75 110 591853 35041 109962295
Skin erosion 19.10 13.75 4 591959 5850 109991486
Amnesia 19.05 13.75 717 591246 104691 109892645
Blood iron decreased 19.05 13.75 47 591916 19167 109978169
Bone density increased 18.98 13.75 25 591938 970 109996366
Venous thrombosis 18.90 13.75 11 591952 8494 109988842
Torus fracture 18.87 13.75 11 591952 135 109997201
Feeling hot 18.72 13.75 359 591604 90747 109906589
Thrombocytosis 18.67 13.75 17 591946 10427 109986909
Obstruction 18.63 13.75 4 591959 5748 109991588
Blindness 18.60 13.75 116 591847 36243 109961093
Macular oedema 18.58 13.75 7 591956 6959 109990377
Lung transplant 18.56 13.75 3 591960 5283 109992053
Hyperpyrexia 18.56 13.75 10 591953 8059 109989277
Arthropod sting 18.54 13.75 30 591933 1406 109995930
Allergy to chemicals 18.42 13.75 49 591914 3276 109994060
Facial paralysis 18.41 13.75 67 591896 24147 109973189
Sinus node dysfunction 18.33 13.75 13 591950 9034 109988302
Haemoglobin abnormal 18.30 13.75 13 591950 9025 109988311
Electrocardiogram T wave inversion 18.29 13.75 4 591959 5676 109991660
Pruritus 18.24 13.75 3455 588508 578105 109419231
Pericardial haemorrhage 18.23 13.75 3 591960 5214 109992122
Hepatic enzyme 18.23 13.75 65 591898 5098 109992238
Peptic ulcer 18.19 13.75 9 591954 7610 109989726
Intestinal ischaemia 18.14 13.75 37 591926 16142 109981194
Concussion 18.11 13.75 21 591942 11517 109985819
Inflammatory bowel disease 18.11 13.75 8 591955 7226 109990110
Ocular icterus 18.06 13.75 5 591958 6048 109991288
Rheumatic disorder 17.99 13.75 51 591912 3540 109993796
Sluggishness 17.97 13.75 9 591954 7558 109989778
Intestinal polyp 17.95 13.75 40 591923 2389 109994947
Eosinophil count decreased 17.90 13.75 5 591958 6013 109991323
Cardiac valve disease 17.90 13.75 6 591957 6415 109990921
Hepatic cancer 17.84 13.75 20 591943 11136 109986200
Multiple-drug resistance 17.80 13.75 27 591936 13208 109984128
Paranasal sinus inflammation 17.80 13.75 14 591949 289 109997047
Cardiac operation 17.80 13.75 5 591958 5990 109991346
Decubitus ulcer 17.77 13.75 45 591918 18191 109979145
Skin fissures 17.73 13.75 69 591894 24389 109972947
Herpes simplex 17.72 13.75 36 591927 15728 109981608
Weight fluctuation 17.71 13.75 189 591774 21956 109975380
Blood chloride increased 17.68 13.75 6 591957 6366 109990970
Hypoproteinaemia 17.57 13.75 5 591958 5940 109991396
Antineutrophil cytoplasmic antibody positive 17.56 13.75 3 591960 5073 109992263
Skin disorder 17.55 13.75 146 591817 42767 109954569
Hepatic lesion 17.48 13.75 12 591951 8481 109988855
Application site pain 17.45 13.75 4 591959 5495 109991841
Blood test abnormal 17.39 13.75 86 591877 28468 109968868
Lumbar vertebral fracture 17.37 13.75 14 591949 9117 109988219
Clostridial infection 17.37 13.75 6 591957 6296 109991040
Product physical issue 17.37 13.75 3 591960 5033 109992303
Peroneal nerve palsy 17.33 13.75 9 591954 7405 109989931
Ear canal erythema 17.31 13.75 8 591955 58 109997278
Lung neoplasm malignant 17.30 13.75 108 591855 33734 109963602
Tooth loss 17.26 13.75 11 591952 8085 109989251
Emotional disorder 17.25 13.75 38 591925 16122 109981214
Haemorrhoidal haemorrhage 17.24 13.75 11 591952 8082 109989254
Drug specific antibody present 17.24 13.75 90 591873 8344 109988992
Hepatic enzyme abnormal 17.16 13.75 100 591863 9663 109987673
Smear cervix abnormal 17.14 13.75 42 591921 2670 109994666
Procedural complication 17.13 13.75 12 591951 8393 109988943
Haemolytic uraemic syndrome 17.13 13.75 3 591960 4982 109992354
Disseminated mucormycosis 17.12 13.75 36 591927 2066 109995270
Peripheral coldness 17.12 13.75 47 591916 18493 109978843
Respiratory tract congestion 17.08 13.75 96 591867 30761 109966575
Facial bones fracture 17.06 13.75 3 591960 4968 109992368
Rheumatoid factor 17.05 13.75 18 591945 550 109996786
Androgenetic alopecia 17.05 13.75 13 591950 256 109997080
Heavy menstrual bleeding 17.04 13.75 39 591924 16326 109981010
Photopsia 16.99 13.75 6 591957 6208 109991128
Adenoiditis 16.98 13.75 7 591956 37 109997299
Feeding disorder 16.98 13.75 58 591905 21304 109976032
Gastropleural fistula 16.97 13.75 8 591955 61 109997275
Prostate cancer metastatic 16.93 13.75 3 591960 4940 109992396
Varicose vein 16.87 13.75 8 591955 6932 109990404
Injection site discomfort 16.73 13.75 8 591955 6899 109990437
Diabetic eye disease 16.70 13.75 12 591951 215 109997121
Stridor 16.68 13.75 8 591955 6887 109990449
Necrosis 16.60 13.75 22 591941 11384 109985952
Clubbing 16.57 13.75 21 591942 784 109996552
Premature baby 16.51 13.75 3 591960 4852 109992484
Peripheral vascular disorder 16.51 13.75 13 591950 8563 109988773
Dysaesthesia 16.48 13.75 8 591955 6839 109990497
Psychiatric symptom 16.46 13.75 15 591948 9198 109988138
Retching 16.44 13.75 64 591899 22618 109974718
Thiopurine methyltransferase decreased 16.42 13.75 14 591949 325 109997011
Mean cell haemoglobin decreased 16.39 13.75 79 591884 7095 109990241
Upper-airway cough syndrome 16.34 13.75 38 591925 15819 109981517
Poor venous access 16.34 13.75 202 591761 24320 109973016
Pseudomonas infection 16.33 13.75 85 591878 27768 109969568
Atypical pneumonia 16.33 13.75 11 591952 7851 109989485
Tumour haemorrhage 16.28 13.75 4 591959 5241 109992095
Gastrointestinal perforation 16.24 13.75 81 591882 7375 109989961
Coronary artery bypass 16.24 13.75 6 591957 6036 109991300
Vaginal haematoma 16.21 13.75 10 591953 137 109997199
Hereditary motor and sensory neuropathy 16.21 13.75 10 591953 137 109997199
Catheter site erythema 16.17 13.75 6 591957 6022 109991314
Limb discomfort 16.17 13.75 308 591655 40546 109956790
Bladder transitional cell carcinoma 16.11 13.75 42 591921 2774 109994562
Gallbladder disorder 16.11 13.75 58 591905 20971 109976365
Hereditary angioedema 16.10 13.75 9 591954 7105 109990231
Disseminated large cell lymphoma 16.04 13.75 8 591955 70 109997266
Atypical mycobacterial infection 16.03 13.75 41 591922 2677 109994659
Red blood cells urine positive 16.01 13.75 4 591959 5181 109992155
Cheilitis 15.99 13.75 7 591956 6358 109990978
Tongue disorder 15.94 13.75 131 591832 14167 109983169
Injection site inflammation 15.94 13.75 59 591904 4712 109992624
Drug dependence 15.88 13.75 181 591782 49839 109947497
Breast cancer stage I 15.79 13.75 10 591953 7377 109989959
Defaecation disorder 15.77 13.75 21 591942 824 109996512
Cardiac pacemaker insertion 15.72 13.75 7 591956 6294 109991042
Intentional dose omission 15.64 13.75 55 591908 20025 109977311
Entropion 15.61 13.75 9 591954 108 109997228
Cholecystectomy 15.58 13.75 21 591942 10788 109986548
Temperature intolerance 15.56 13.75 32 591931 13918 109983418
Staphylococcal sepsis 15.56 13.75 45 591918 17409 109979927
Respiratory rate decreased 15.54 13.75 7 591956 6251 109991085
Parainfluenzae virus infection 15.53 13.75 9 591954 6965 109990371
Bronchitis viral 15.51 13.75 27 591936 1344 109995992
Infected varicose vein 15.51 13.75 6 591957 26 109997310
Metastatic neoplasm 15.50 13.75 6 591957 5867 109991469
Intestinal perforation 15.49 13.75 176 591787 20768 109976568
Premature rupture of membranes 15.48 13.75 3 591960 4634 109992702
Device related sepsis 15.48 13.75 11 591952 7636 109989700
Rhinitis 15.46 13.75 65 591898 22480 109974856
Vitreous haemorrhage 15.40 13.75 3 591960 4617 109992719
Communication disorder 15.34 13.75 4 591959 5035 109992301
Gastric infection 15.31 13.75 54 591909 4212 109993124
Hypertensive heart disease 15.29 13.75 3 591960 4593 109992743
Immune-mediated myositis 15.24 13.75 7 591956 6179 109991157
Nasal ulcer 15.23 13.75 39 591924 2548 109994788
Cell death 15.15 13.75 6 591957 5785 109991551
Drug-induced liver injury 15.13 13.75 787 591176 119280 109878056
Blepharitis 15.08 13.75 3 591960 4549 109992787
Wrist surgery 15.08 13.75 21 591942 860 109996476
Renal cell carcinoma 15.02 13.75 11 591952 7519 109989817
Vitamin D deficiency 15.00 13.75 50 591913 18502 109978834
Epigastric discomfort 14.98 13.75 91 591872 8924 109988412
Mycotic endophthalmitis 14.96 13.75 15 591948 431 109996905
Spinal fusion surgery 14.95 13.75 92 591871 9064 109988272
Sebaceous gland infection 14.93 13.75 10 591953 159 109997177
Influenza 14.92 13.75 746 591217 168355 109828981
Jugular vein thrombosis 14.89 13.75 5 591958 5340 109991996
Overweight 14.89 13.75 8 591955 6456 109990880
Tooth fracture 14.88 13.75 121 591842 13046 109984290
Nail injury 14.86 13.75 20 591943 793 109996543
Rebound effect 14.85 13.75 36 591927 14770 109982566
Bacille Calmette-Guerin scar reactivation 14.82 13.75 6 591957 30 109997306
Thrombosis in device 14.81 13.75 5 591958 5322 109992014
Therapy partial responder 14.74 13.75 127 591836 36934 109960402
Red blood cell sedimentation rate decreased 14.74 13.75 26 591937 1308 109996028
Inflammatory marker decreased 14.72 13.75 4 591959 3 109997333
Immune-mediated lung disease 14.70 13.75 5 591958 5298 109992038
Interleukin level increased 14.67 13.75 29 591934 1592 109995744
Diaphragmatic rupture 14.62 13.75 11 591952 212 109997124
Oral fungal infection 14.61 13.75 3 591960 4449 109992887
Spinal osteoarthritis 14.59 13.75 57 591906 20126 109977210
Bladder prolapse 14.53 13.75 27 591936 1415 109995921
Cytomegalovirus colitis 14.50 13.75 10 591953 7051 109990285
Hypocomplementaemia 14.48 13.75 13 591950 324 109997012
Upper respiratory tract infection 14.42 13.75 850 591113 130478 109866858
Blood glucose fluctuation 14.40 13.75 12 591951 7686 109989650
Ischaemic cardiomyopathy 14.37 13.75 13 591950 7998 109989338
Depression suicidal 14.36 13.75 4 591959 4820 109992516
Chronic lymphocytic leukaemia 14.32 13.75 7 591956 5961 109991375
Syringe issue 14.25 13.75 18 591945 9507 109987829
Anaphylactic reaction 14.17 13.75 485 591478 113815 109883521
Head discomfort 14.16 13.75 53 591910 18947 109978389
Tenosynovitis stenosans 14.15 13.75 47 591916 3556 109993780
Emphysema 14.15 13.75 56 591907 19700 109977636
Human anti-human antibody test 14.11 13.75 14 591949 397 109996939
Graft versus host disease in skin 14.09 13.75 14 591949 8240 109989096
CD4/CD8 ratio increased 14.09 13.75 5 591958 16 109997320
Visual field defect 14.08 13.75 20 591943 10052 109987284
Gastrointestinal inflammation 14.05 13.75 18 591945 9451 109987885
Intermenstrual bleeding 14.00 13.75 10 591953 6924 109990412
Gastric polyps 14.00 13.75 6 591957 5517 109991819
Rheumatoid factor increased 13.97 13.75 37 591926 2468 109994868
Livedo reticularis 13.92 13.75 6 591957 5500 109991836
Bordetella infection 13.91 13.75 11 591952 229 109997107
Bronchiolitis 13.87 13.75 6 591957 5487 109991849
Spinal cord compression 13.85 13.75 12 591951 7540 109989796
Rash pustular 13.83 13.75 30 591933 12799 109984537
Increased appetite 13.80 13.75 38 591925 14939 109982397

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AC07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Interleukin inhibitors
FDA MoA N0000190478 Interleukin 6 Receptor Antagonists
FDA EPC N0000190480 Interleukin-6 Receptor Antagonist

Related Drugs by ATC class:

L04AC Interleukin inhibitors 18 drugs
anakinrabasiliximabbimekizumabbrodalumabcanakinumabdaclizumabguselkumabixekizumabmirikizumabrilonaceptrisankizumabsarilumab show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Castleman's disease indication 207036003 DOID:0111157
Juvenile idiopathic arthritis indication 410502007
Still's disease indication 410794002
Juvenile rheumatoid arthritis indication 410795001
Juvenile seropositive polyarthritis indication 410796000
Juvenile seronegative polyarthritis indication 410797009
Juvenile idiopathic arthritis, extended oligoarthritis indication 410800006
Giant cell arteritis indication 414341000 DOID:13375
Cytokine release syndrome induced by tumor-specific T-cell infusion therapy indication 710027002
Pneumonia caused by Severe acute respiratory syndrome coronavirus 2 indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Interleukin-6 receptor subunit alpha Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D02596 KEGG_DRUG
4029705 VUID
N0000180629 NUI
4029705 VANDF
CHEMBL1237022 ChEMBL_ID
C502936 MESH_SUPPLEMENTAL_RECORD_UI
6881 IUPHAR_LIGAND_ID
DB06273 DRUGBANK_ID
612865 RXNORM
169600 MMSL
26778 MMSL
d07496 MMSL
013198 NDDF
444648007 SNOMEDCT_US
444649004 SNOMEDCT_US
C1609165 UMLSCUI
8394 INN_ID
10150081 PUBCHEM_CID
I031V2H011 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-135 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-136 INJECTION, SOLUTION, CONCENTRATE 200 mg INTRAVENOUS BLA 33 sections
ACTEMRA HUMAN PRESCRIPTION DRUG LABEL 1 50242-137 INJECTION, SOLUTION, CONCENTRATE 400 mg INTRAVENOUS BLA 33 sections
Actemra HUMAN PRESCRIPTION DRUG LABEL 1 50242-138 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
Actemra ACTPen HUMAN PRESCRIPTION DRUG LABEL 1 50242-143 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
Tofidence HUMAN PRESCRIPTION DRUG LABEL 1 64406-022 INJECTION 20 mg INTRAVENOUS BLA 34 sections
Tofidence HUMAN PRESCRIPTION DRUG LABEL 1 64406-023 INJECTION 20 mg INTRAVENOUS BLA 34 sections
Tofidence HUMAN PRESCRIPTION DRUG LABEL 1 64406-024 INJECTION 20 mg INTRAVENOUS BLA 34 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-584 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-586 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-590 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS BLA 32 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-592 INJECTION, SOLUTION, CONCENTRATE 200 mg INTRAVENOUS BLA 32 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-594 INJECTION, SOLUTION, CONCENTRATE 400 mg INTRAVENOUS BLA 32 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-596 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
TYENNE HUMAN PRESCRIPTION DRUG LABEL 1 65219-598 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 33 sections
AVTOZMA HUMAN PRESCRIPTION DRUG LABEL 1 72606-042 INJECTION, SOLUTION 80 mg INTRAVENOUS BLA 35 sections
AVTOZMA HUMAN PRESCRIPTION DRUG LABEL 1 72606-043 INJECTION, SOLUTION 200 mg INTRAVENOUS BLA 35 sections
AVTOZMA HUMAN PRESCRIPTION DRUG LABEL 1 72606-044 INJECTION, SOLUTION 400 mg INTRAVENOUS BLA 35 sections
AVTOZMA HUMAN PRESCRIPTION DRUG LABEL 1 72606-045 INJECTION, SOLUTION 162 mg SUBCUTANEOUS BLA 35 sections
Tocilizumab-anoh HUMAN PRESCRIPTION DRUG LABEL 1 72606-048 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS BLA 35 sections
Tocilizumab-anoh HUMAN PRESCRIPTION DRUG LABEL 1 72606-049 INJECTION, SOLUTION, CONCENTRATE 200 mg INTRAVENOUS BLA 35 sections
Tocilizumab-anoh HUMAN PRESCRIPTION DRUG LABEL 1 72606-050 INJECTION, SOLUTION, CONCENTRATE 400 mg INTRAVENOUS BLA 35 sections
Tocilizumab-anoh HUMAN PRESCRIPTION DRUG LABEL 1 72606-051 INJECTION, SOLUTION, CONCENTRATE 162 mg INTRAVENOUS BLA 35 sections
TOFIDENCE HUMAN PRESCRIPTION DRUG LABEL 1 78206-200 INJECTION 80 mg INTRAVENOUS BLA 34 sections
TOFIDENCE HUMAN PRESCRIPTION DRUG LABEL 1 78206-201 INJECTION 200 mg INTRAVENOUS BLA 34 sections
TOFIDENCE HUMAN PRESCRIPTION DRUG LABEL 1 78206-202 INJECTION 400 mg INTRAVENOUS BLA 34 sections