Stem definition | Drug id | CAS RN |
---|---|---|
humanized origin | 4933 | 375823-41-9 |
Molecule | Description |
---|---|
Synonyms:
|
a humanised anti-interleukin-6 receptor monoclonal antibody
|
Dose | Unit | Route |
---|---|---|
20 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 16, 2009 | EMA | ||
Jan. 8, 2010 | FDA | GENENTECH | |
March 6, 2008 | PMDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 5650.22 | 14.61 | 14249 | 299989 | 805084 | 49485802 |
Contraindicated product administered | 3991.52 | 14.61 | 4763 | 309475 | 144195 | 50146691 |
Joint swelling | 3260.76 | 14.61 | 5615 | 308623 | 239671 | 50051215 |
Drug intolerance | 3025.88 | 14.61 | 5103 | 309135 | 214001 | 50076885 |
Treatment failure | 2960.32 | 14.61 | 3946 | 310292 | 133691 | 50157195 |
Synovitis | 2920.17 | 14.61 | 3716 | 310522 | 120149 | 50170737 |
Arthropathy | 2240.78 | 14.61 | 3726 | 310512 | 154180 | 50136706 |
Therapeutic product effect decreased | 2133.67 | 14.61 | 3360 | 310878 | 132690 | 50158196 |
Pemphigus | 1976.24 | 14.61 | 3034 | 311204 | 117132 | 50173754 |
Systemic lupus erythematosus | 1843.04 | 14.61 | 3204 | 311034 | 137418 | 50153468 |
Swelling | 1697.68 | 14.61 | 3806 | 310432 | 197066 | 50093820 |
Glossodynia | 1561.76 | 14.61 | 2670 | 311568 | 112899 | 50177987 |
Pain | 1520.80 | 14.61 | 7345 | 306893 | 571558 | 49719328 |
Hand deformity | 1452.28 | 14.61 | 2389 | 311849 | 97810 | 50193076 |
Arthralgia | 1421.07 | 14.61 | 5927 | 308311 | 432775 | 49858111 |
Abdominal discomfort | 1304.82 | 14.61 | 3765 | 310473 | 227876 | 50063010 |
Rheumatoid arthritis | 1196.53 | 14.61 | 3350 | 310888 | 199200 | 50091686 |
Hypersensitivity | 1158.41 | 14.61 | 3442 | 310796 | 211719 | 50079167 |
Hepatic enzyme increased | 1152.08 | 14.61 | 2597 | 311641 | 134783 | 50156103 |
Alopecia | 1091.88 | 14.61 | 3672 | 310566 | 241375 | 50049511 |
Rheumatoid factor positive | 1083.53 | 14.61 | 1439 | 312799 | 48420 | 50242466 |
Infusion related reaction | 1049.05 | 14.61 | 2853 | 311385 | 166704 | 50124182 |
Wound | 1017.06 | 14.61 | 2114 | 312124 | 103680 | 50187206 |
Anti-cyclic citrullinated peptide antibody positive | 940.89 | 14.61 | 1622 | 312616 | 68965 | 50221921 |
Death | 936.97 | 14.61 | 425 | 313813 | 324954 | 49965932 |
Rash | 908.10 | 14.61 | 5208 | 309030 | 432263 | 49858623 |
Toxicity to various agents | 885.89 | 14.61 | 132 | 314106 | 212367 | 50078519 |
C-reactive protein abnormal | 851.95 | 14.61 | 955 | 313283 | 26854 | 50264032 |
Acute kidney injury | 848.92 | 14.61 | 189 | 314049 | 227869 | 50063017 |
Lower respiratory tract infection | 839.43 | 14.61 | 1837 | 312401 | 93364 | 50197522 |
Peripheral swelling | 827.10 | 14.61 | 2983 | 311255 | 202953 | 50087933 |
Musculoskeletal stiffness | 821.31 | 14.61 | 2189 | 312049 | 126292 | 50164594 |
Infection | 807.83 | 14.61 | 2635 | 311603 | 170319 | 50120567 |
Drug interaction | 796.18 | 14.61 | 140 | 314098 | 199481 | 50091405 |
Pericarditis | 784.89 | 14.61 | 1597 | 312641 | 77092 | 50213794 |
Red blood cell sedimentation rate abnormal | 725.05 | 14.61 | 685 | 313553 | 15658 | 50275228 |
Anaemia | 687.75 | 14.61 | 355 | 313883 | 252101 | 50038785 |
Loss of personal independence in daily activities | 678.83 | 14.61 | 1405 | 312833 | 68645 | 50222241 |
Ill-defined disorder | 658.64 | 14.61 | 1202 | 313036 | 53452 | 50237434 |
Discomfort | 656.76 | 14.61 | 1811 | 312427 | 106569 | 50184317 |
Muscle injury | 616.99 | 14.61 | 943 | 313295 | 36168 | 50254718 |
Folliculitis | 612.07 | 14.61 | 968 | 313270 | 38257 | 50252629 |
Impaired healing | 606.24 | 14.61 | 1339 | 312899 | 68447 | 50222439 |
Product use issue | 576.47 | 14.61 | 2138 | 312100 | 147337 | 50143549 |
Dehydration | 551.72 | 14.61 | 134 | 314104 | 152315 | 50138571 |
Maternal exposure during pregnancy | 502.33 | 14.61 | 2144 | 312094 | 157634 | 50133252 |
Irritable bowel syndrome | 492.62 | 14.61 | 1027 | 313211 | 50414 | 50240472 |
Hyponatraemia | 490.03 | 14.61 | 26 | 314212 | 96113 | 50194773 |
Drug hypersensitivity | 489.94 | 14.61 | 2944 | 311294 | 248066 | 50042820 |
Product dose omission issue | 476.33 | 14.61 | 275 | 313963 | 183563 | 50107323 |
Red blood cell sedimentation rate increased | 475.63 | 14.61 | 738 | 313500 | 28678 | 50262208 |
Febrile neutropenia | 469.32 | 14.61 | 36 | 314202 | 97631 | 50193255 |
Dizziness | 451.10 | 14.61 | 921 | 313317 | 345448 | 49945438 |
Decreased appetite | 450.25 | 14.61 | 353 | 313885 | 200570 | 50090316 |
Helicobacter infection | 448.98 | 14.61 | 969 | 313269 | 48733 | 50242153 |
Nausea | 444.13 | 14.61 | 2572 | 311666 | 702826 | 49588060 |
Sleep disorder due to general medical condition, insomnia type | 438.95 | 14.61 | 738 | 313500 | 30709 | 50260177 |
Duodenal ulcer perforation | 431.34 | 14.61 | 906 | 313332 | 44705 | 50246181 |
Nasopharyngitis | 423.35 | 14.61 | 2335 | 311903 | 190592 | 50100294 |
Therapeutic product effect incomplete | 419.96 | 14.61 | 1387 | 312851 | 90128 | 50200758 |
Blister | 413.07 | 14.61 | 1318 | 312920 | 84100 | 50206786 |
Constipation | 412.62 | 14.61 | 329 | 313909 | 185379 | 50105507 |
Seizure | 410.32 | 14.61 | 112 | 314126 | 117762 | 50173124 |
Intentional product use issue | 400.71 | 14.61 | 1218 | 313020 | 75700 | 50215186 |
Tremor | 400.29 | 14.61 | 109 | 314129 | 114794 | 50176092 |
Anxiety | 391.63 | 14.61 | 317 | 313921 | 177289 | 50113597 |
Injection site pain | 383.61 | 14.61 | 107 | 314131 | 110917 | 50179969 |
Diarrhoea | 377.17 | 14.61 | 2132 | 312106 | 586344 | 49704542 |
C-reactive protein increased | 377.07 | 14.61 | 1085 | 313153 | 65389 | 50225497 |
Intentional overdose | 370.77 | 14.61 | 3 | 314235 | 62501 | 50228385 |
Sinusitis | 360.56 | 14.61 | 2044 | 312194 | 168514 | 50122372 |
Bone erosion | 358.92 | 14.61 | 402 | 313836 | 11285 | 50279601 |
Overdose | 352.29 | 14.61 | 92 | 314146 | 99635 | 50191251 |
Condition aggravated | 345.02 | 14.61 | 3078 | 311160 | 293980 | 49996906 |
Rheumatoid nodule | 339.06 | 14.61 | 407 | 313831 | 12328 | 50278558 |
Somnolence | 325.25 | 14.61 | 290 | 313948 | 154695 | 50136191 |
Cardiac arrest | 323.87 | 14.61 | 63 | 314175 | 83588 | 50207298 |
Hypotension | 323.58 | 14.61 | 606 | 313632 | 234863 | 50056023 |
Knee arthroplasty | 322.69 | 14.61 | 698 | 313540 | 35148 | 50255738 |
Depression | 315.38 | 14.61 | 337 | 313901 | 165086 | 50125800 |
Renal failure | 314.51 | 14.61 | 134 | 314104 | 106499 | 50184387 |
Off label use | 311.65 | 14.61 | 4393 | 309845 | 470033 | 49820853 |
Cardiac failure congestive | 309.40 | 14.61 | 72 | 314166 | 84310 | 50206576 |
Blood iron abnormal | 304.73 | 14.61 | 213 | 314025 | 3113 | 50287773 |
Thrombocytopenia | 300.39 | 14.61 | 213 | 314025 | 127460 | 50163426 |
Asthenia | 298.31 | 14.61 | 1001 | 313237 | 318041 | 49972845 |
Dyspnoea | 296.40 | 14.61 | 2089 | 312149 | 545519 | 49745367 |
Bradycardia | 295.17 | 14.61 | 29 | 314209 | 64397 | 50226489 |
Electrocardiogram QT prolonged | 288.55 | 14.61 | 7 | 314231 | 51879 | 50239007 |
Tachycardia | 286.89 | 14.61 | 130 | 314108 | 99633 | 50191253 |
Muscle spasms | 283.06 | 14.61 | 219 | 314019 | 125334 | 50165552 |
Neuropathy peripheral | 279.94 | 14.61 | 125 | 314113 | 96632 | 50194254 |
Gastrointestinal disorder | 277.03 | 14.61 | 1242 | 312996 | 93214 | 50197672 |
Hip arthroplasty | 275.57 | 14.61 | 594 | 313644 | 29835 | 50261051 |
Haemoglobin decreased | 275.43 | 14.61 | 231 | 314007 | 126985 | 50163901 |
Hypokalaemia | 275.20 | 14.61 | 101 | 314137 | 87891 | 50202995 |
Joint stiffness | 270.32 | 14.61 | 588 | 313650 | 29720 | 50261166 |
Suicide attempt | 269.94 | 14.61 | 12 | 314226 | 51720 | 50239166 |
Oedema peripheral | 264.69 | 14.61 | 356 | 313882 | 157605 | 50133281 |
Vomiting | 261.81 | 14.61 | 1732 | 312506 | 459026 | 49831860 |
Mobility decreased | 261.10 | 14.61 | 1086 | 313152 | 78862 | 50212024 |
Hypoglycaemia | 256.64 | 14.61 | 20 | 314218 | 53561 | 50237325 |
Skin ulcer | 256.49 | 14.61 | 632 | 313606 | 34686 | 50256200 |
Malignant neoplasm progression | 254.00 | 14.61 | 56 | 314182 | 68068 | 50222818 |
Feeling abnormal | 253.55 | 14.61 | 243 | 313995 | 125249 | 50165637 |
Balance disorder | 253.35 | 14.61 | 63 | 314175 | 70527 | 50220359 |
Hyperkalaemia | 251.43 | 14.61 | 11 | 314227 | 48078 | 50242808 |
Cardio-respiratory arrest | 247.56 | 14.61 | 24 | 314214 | 53868 | 50237018 |
Inflammation | 245.40 | 14.61 | 845 | 313393 | 56067 | 50234819 |
Respiratory failure | 242.29 | 14.61 | 132 | 314106 | 91049 | 50199837 |
Coma | 239.78 | 14.61 | 34 | 314204 | 56845 | 50234041 |
Osteoporosis | 234.84 | 14.61 | 712 | 313526 | 44167 | 50246719 |
Rheumatic fever | 234.21 | 14.61 | 395 | 313843 | 16472 | 50274414 |
Abdominal pain | 233.97 | 14.61 | 722 | 313516 | 235506 | 50055380 |
Depressed level of consciousness | 233.81 | 14.61 | 25 | 314213 | 51928 | 50238958 |
Wrong technique in product usage process | 232.10 | 14.61 | 34 | 314204 | 55476 | 50235410 |
Atrial fibrillation | 231.19 | 14.61 | 176 | 314062 | 101569 | 50189317 |
Blood cholesterol increased | 226.14 | 14.61 | 806 | 313432 | 54409 | 50236477 |
Vision blurred | 223.75 | 14.61 | 104 | 314134 | 78543 | 50212343 |
Stomatitis | 222.83 | 14.61 | 1228 | 313010 | 100116 | 50190770 |
Fall | 222.20 | 14.61 | 1198 | 313040 | 333734 | 49957152 |
Panniculitis | 220.23 | 14.61 | 268 | 313970 | 8235 | 50282651 |
Gastrointestinal haemorrhage | 219.61 | 14.61 | 90 | 314148 | 73231 | 50217655 |
Weight increased | 216.28 | 14.61 | 2057 | 312181 | 199834 | 50091052 |
Rhabdomyolysis | 214.24 | 14.61 | 6 | 314232 | 39021 | 50251865 |
Agitation | 213.50 | 14.61 | 37 | 314201 | 53347 | 50237539 |
Gastrooesophageal reflux disease | 212.93 | 14.61 | 104 | 314134 | 76324 | 50214562 |
Pulmonary embolism | 212.44 | 14.61 | 191 | 314047 | 101513 | 50189373 |
Granuloma skin | 210.02 | 14.61 | 218 | 314020 | 5600 | 50285286 |
Cerebrovascular accident | 208.51 | 14.61 | 169 | 314069 | 94511 | 50196375 |
Pancytopenia | 207.23 | 14.61 | 133 | 314105 | 83897 | 50206989 |
Blood parathyroid hormone decreased | 207.05 | 14.61 | 238 | 314000 | 6876 | 50284010 |
Urinary tract infection | 206.32 | 14.61 | 707 | 313531 | 223313 | 50067573 |
Coeliac disease | 204.55 | 14.61 | 261 | 313977 | 8424 | 50282462 |
Sleep disorder | 204.43 | 14.61 | 800 | 313438 | 56483 | 50234403 |
Arthritis | 204.33 | 14.61 | 1071 | 313167 | 85650 | 50205236 |
Chest discomfort | 201.10 | 14.61 | 168 | 314070 | 92554 | 50198332 |
Deformity | 200.38 | 14.61 | 247 | 313991 | 7693 | 50283193 |
Metabolic acidosis | 199.35 | 14.61 | 10 | 314228 | 38815 | 50252071 |
Paraesthesia | 197.34 | 14.61 | 275 | 313963 | 119968 | 50170918 |
Cognitive disorder | 194.10 | 14.61 | 23 | 314215 | 44100 | 50246786 |
Inappropriate schedule of product administration | 193.74 | 14.61 | 102 | 314136 | 71729 | 50219157 |
Syncope | 191.59 | 14.61 | 214 | 314024 | 102788 | 50188098 |
International normalised ratio increased | 191.06 | 14.61 | 22 | 314216 | 43130 | 50247756 |
Swollen joint count increased | 187.80 | 14.61 | 334 | 313904 | 14539 | 50276347 |
Hallucination | 187.33 | 14.61 | 32 | 314206 | 46625 | 50244261 |
Dysphagia | 186.68 | 14.61 | 126 | 314112 | 77392 | 50213494 |
Chest pain | 185.61 | 14.61 | 526 | 313712 | 176356 | 50114530 |
Memory impairment | 183.20 | 14.61 | 135 | 314103 | 79225 | 50211661 |
Cardiac failure | 182.57 | 14.61 | 124 | 314114 | 75916 | 50214970 |
Ear pain | 175.37 | 14.61 | 477 | 313761 | 27806 | 50263080 |
Lethargy | 171.86 | 14.61 | 47 | 314191 | 49385 | 50241501 |
Joint destruction | 167.68 | 14.61 | 161 | 314077 | 3755 | 50287131 |
Hyperglycaemia | 165.14 | 14.61 | 17 | 314221 | 36388 | 50254498 |
Disability assessment scale score increased | 164.18 | 14.61 | 128 | 314110 | 2230 | 50288656 |
Hypoxia | 162.68 | 14.61 | 57 | 314181 | 51066 | 50239820 |
Chronic obstructive pulmonary disease | 162.60 | 14.61 | 64 | 314174 | 53371 | 50237515 |
Lactic acidosis | 161.00 | 14.61 | 12 | 314226 | 33343 | 50257543 |
Dysarthria | 160.86 | 14.61 | 21 | 314217 | 37382 | 50253504 |
Platelet count decreased | 160.67 | 14.61 | 235 | 314003 | 100491 | 50190395 |
Unresponsive to stimuli | 160.01 | 14.61 | 7 | 314231 | 30602 | 50260284 |
Plasma cell myeloma | 157.89 | 14.61 | 9 | 314229 | 31313 | 50259573 |
Disorientation | 157.32 | 14.61 | 18 | 314220 | 35466 | 50255420 |
Musculoskeletal pain | 154.20 | 14.61 | 868 | 313370 | 71309 | 50219577 |
Disturbance in attention | 154.07 | 14.61 | 10 | 314228 | 31176 | 50259710 |
Suicidal ideation | 153.30 | 14.61 | 76 | 314162 | 55309 | 50235577 |
Epistaxis | 152.58 | 14.61 | 105 | 314133 | 63849 | 50227037 |
Therapeutic response decreased | 152.10 | 14.61 | 639 | 313599 | 46592 | 50244294 |
Myalgia | 151.02 | 14.61 | 343 | 313895 | 123976 | 50166910 |
Hospitalisation | 148.65 | 14.61 | 122 | 314116 | 67815 | 50223071 |
Pleural effusion | 148.45 | 14.61 | 172 | 314066 | 81282 | 50209604 |
Pulmonary fibrosis | 148.38 | 14.61 | 409 | 313829 | 24028 | 50266858 |
Injection site erythema | 147.95 | 14.61 | 148 | 314090 | 74788 | 50216098 |
Blood alkaline phosphatase increased | 147.90 | 14.61 | 27 | 314211 | 37499 | 50253387 |
Blood glucose increased | 147.66 | 14.61 | 135 | 314103 | 71189 | 50219697 |
Neoplasm progression | 145.09 | 14.61 | 9 | 314229 | 29148 | 50261738 |
Deep vein thrombosis | 144.47 | 14.61 | 145 | 314093 | 73159 | 50217727 |
No adverse event | 144.21 | 14.61 | 498 | 313740 | 33080 | 50257806 |
Incorrect dose administered | 144.03 | 14.61 | 60 | 314178 | 48354 | 50242532 |
Muscle spasticity | 143.75 | 14.61 | 325 | 313913 | 16859 | 50274027 |
Mental status changes | 143.16 | 14.61 | 26 | 314212 | 36246 | 50254640 |
Disease progression | 143.01 | 14.61 | 234 | 314004 | 95632 | 50195254 |
Palpitations | 142.55 | 14.61 | 229 | 314009 | 94277 | 50196609 |
Respiratory arrest | 141.48 | 14.61 | 12 | 314226 | 29997 | 50260889 |
Psoriatic arthropathy | 140.46 | 14.61 | 622 | 313616 | 46410 | 50244476 |
Skin necrosis | 139.73 | 14.61 | 246 | 313992 | 10621 | 50280265 |
Sedation | 139.61 | 14.61 | 14 | 314224 | 30596 | 50260290 |
Limb deformity | 138.55 | 14.61 | 142 | 314096 | 3592 | 50287294 |
Drug tolerance decreased | 137.23 | 14.61 | 222 | 314016 | 8938 | 50281948 |
Orthostatic hypotension | 135.73 | 14.61 | 13 | 314225 | 29468 | 50261418 |
Neutropenia | 135.41 | 14.61 | 468 | 313770 | 147497 | 50143389 |
Musculoskeletal deformity | 134.92 | 14.61 | 81 | 314157 | 897 | 50289989 |
Diverticulitis | 133.79 | 14.61 | 482 | 313756 | 32700 | 50258186 |
Hypophagia | 133.76 | 14.61 | 10 | 314228 | 27718 | 50263168 |
Foot deformity | 132.36 | 14.61 | 337 | 313901 | 18873 | 50272013 |
Fatigue | 131.93 | 14.61 | 5505 | 308733 | 702096 | 49588790 |
Muscular weakness | 131.63 | 14.61 | 243 | 313995 | 94770 | 50196116 |
Product quality issue | 131.09 | 14.61 | 18 | 314220 | 30840 | 50260046 |
Dyskinesia | 129.03 | 14.61 | 12 | 314226 | 27849 | 50263037 |
Bronchitis chronic | 128.81 | 14.61 | 139 | 314099 | 3738 | 50287148 |
Blood potassium decreased | 128.67 | 14.61 | 35 | 314203 | 36910 | 50253976 |
Generalised tonic-clonic seizure | 128.32 | 14.61 | 9 | 314229 | 26301 | 50264585 |
Coronary artery disease | 127.09 | 14.61 | 17 | 314221 | 29709 | 50261177 |
Sciatica | 126.99 | 14.61 | 355 | 313883 | 21027 | 50269859 |
Skin exfoliation | 126.55 | 14.61 | 27 | 314211 | 33585 | 50257301 |
Immobile | 125.57 | 14.61 | 156 | 314082 | 4898 | 50285988 |
Pulmonary oedema | 124.03 | 14.61 | 75 | 314163 | 48863 | 50242023 |
Emotional distress | 123.48 | 14.61 | 16 | 314222 | 28647 | 50262239 |
Pneumonia | 123.33 | 14.61 | 1633 | 312605 | 376768 | 49914118 |
Pneumonia aspiration | 122.85 | 14.61 | 22 | 314216 | 30982 | 50259904 |
Osteonecrosis of jaw | 122.72 | 14.61 | 26 | 314212 | 32500 | 50258386 |
Body temperature increased | 121.92 | 14.61 | 450 | 313788 | 30891 | 50259995 |
Intentional self-injury | 121.76 | 14.61 | 5 | 314233 | 23107 | 50267779 |
Tenosynovitis | 121.67 | 14.61 | 228 | 314010 | 10337 | 50280549 |
Blood pressure systolic increased | 121.54 | 14.61 | 489 | 313749 | 34960 | 50255926 |
Mucosal inflammation | 120.62 | 14.61 | 49 | 314189 | 40093 | 50250793 |
Ascites | 119.33 | 14.61 | 37 | 314201 | 35824 | 50255062 |
Intentional product misuse | 117.92 | 14.61 | 72 | 314166 | 46662 | 50244224 |
Irritability | 117.46 | 14.61 | 18 | 314220 | 28408 | 50262478 |
Depressed mood | 117.05 | 14.61 | 33 | 314205 | 33990 | 50256896 |
Dysgeusia | 116.13 | 14.61 | 48 | 314190 | 38868 | 50252018 |
Aggression | 113.19 | 14.61 | 4 | 314234 | 21112 | 50269774 |
Toxic epidermal necrolysis | 112.44 | 14.61 | 4 | 314234 | 20988 | 50269898 |
Blood bilirubin increased | 112.23 | 14.61 | 30 | 314208 | 32008 | 50258878 |
Blood pressure diastolic abnormal | 111.54 | 14.61 | 205 | 314033 | 9156 | 50281730 |
Immunodeficiency | 111.52 | 14.61 | 269 | 313969 | 14559 | 50276327 |
Cough | 110.92 | 14.61 | 961 | 313277 | 240303 | 50050583 |
Temperature regulation disorder | 110.72 | 14.61 | 134 | 314104 | 4093 | 50286793 |
Hypervolaemia | 110.41 | 14.61 | 14 | 314224 | 25485 | 50265401 |
Blood pressure systolic abnormal | 110.36 | 14.61 | 183 | 314055 | 7523 | 50283363 |
Blood pressure diastolic decreased | 110.06 | 14.61 | 289 | 313949 | 16492 | 50274394 |
Chills | 110.06 | 14.61 | 276 | 313962 | 96411 | 50194475 |
Treatment noncompliance | 109.93 | 14.61 | 26 | 314212 | 30124 | 50260762 |
Sepsis | 109.47 | 14.61 | 439 | 313799 | 132486 | 50158400 |
Oral mucosal exfoliation | 109.35 | 14.61 | 85 | 314153 | 1474 | 50289412 |
Liver function test increased | 109.28 | 14.61 | 379 | 313859 | 25227 | 50265659 |
Dyspnoea exertional | 108.40 | 14.61 | 95 | 314143 | 51138 | 50239748 |
Abnormal behaviour | 107.97 | 14.61 | 3 | 314235 | 19655 | 50271231 |
Drug eruption | 107.43 | 14.61 | 357 | 313881 | 23249 | 50267637 |
Body height below normal | 106.72 | 14.61 | 92 | 314146 | 1857 | 50289029 |
Blood pressure decreased | 106.31 | 14.61 | 114 | 314124 | 55795 | 50235091 |
Restlessness | 106.19 | 14.61 | 15 | 314223 | 25158 | 50265728 |
Type 2 diabetes mellitus | 105.97 | 14.61 | 459 | 313779 | 33916 | 50256970 |
Osteoarthritis | 104.96 | 14.61 | 758 | 313480 | 67848 | 50223038 |
Psychotic disorder | 104.84 | 14.61 | 8 | 314230 | 21804 | 50269082 |
Investigation abnormal | 104.35 | 14.61 | 76 | 314162 | 1189 | 50289697 |
Accidental exposure to product | 103.98 | 14.61 | 11 | 314227 | 23046 | 50267840 |
Joint laxity | 103.45 | 14.61 | 99 | 314139 | 2299 | 50288587 |
Delirium | 103.31 | 14.61 | 54 | 314184 | 38138 | 50252748 |
Dysuria | 103.10 | 14.61 | 25 | 314213 | 28479 | 50262407 |
Bone pain | 103.07 | 14.61 | 85 | 314153 | 47144 | 50243742 |
Foetal exposure during pregnancy | 102.95 | 14.61 | 22 | 314216 | 27337 | 50263549 |
Flushing | 102.35 | 14.61 | 161 | 314077 | 66854 | 50224032 |
Abdominal distension | 102.26 | 14.61 | 185 | 314053 | 72718 | 50218168 |
Stevens-Johnson syndrome | 101.72 | 14.61 | 9 | 314229 | 21743 | 50269143 |
Basal cell carcinoma | 101.68 | 14.61 | 348 | 313890 | 23008 | 50267878 |
Blood calcium decreased | 101.23 | 14.61 | 7 | 314231 | 20699 | 50270187 |
Pulmonary hypertension | 100.07 | 14.61 | 41 | 314197 | 33376 | 50257510 |
Encephalopathy | 99.91 | 14.61 | 42 | 314196 | 33669 | 50257217 |
Sinus tachycardia | 99.41 | 14.61 | 9 | 314229 | 21345 | 50269541 |
Bone marrow failure | 98.42 | 14.61 | 25 | 314213 | 27599 | 50263287 |
Blood sodium decreased | 98.22 | 14.61 | 9 | 314229 | 21138 | 50269748 |
Aphasia | 97.35 | 14.61 | 28 | 314210 | 28466 | 50262420 |
Fibromyalgia | 96.75 | 14.61 | 542 | 313696 | 44436 | 50246450 |
Urinary retention | 96.65 | 14.61 | 22 | 314216 | 26168 | 50264718 |
Pyrexia | 94.90 | 14.61 | 1726 | 312512 | 378477 | 49912409 |
Pulmonary toxicity | 94.73 | 14.61 | 143 | 314095 | 5419 | 50285467 |
Human antichimeric antibody positive | 93.35 | 14.61 | 76 | 314162 | 1413 | 50289473 |
Rectal haemorrhage | 92.37 | 14.61 | 63 | 314175 | 38495 | 50252391 |
Pneumonia viral | 92.16 | 14.61 | 158 | 314080 | 6676 | 50284210 |
Red blood cell sedimentation rate | 91.20 | 14.61 | 112 | 314126 | 3474 | 50287412 |
Blood urea increased | 90.75 | 14.61 | 18 | 314220 | 23567 | 50267319 |
Jaundice | 90.24 | 14.61 | 26 | 314212 | 26403 | 50264483 |
Presyncope | 89.95 | 14.61 | 20 | 314218 | 24178 | 50266708 |
Drug reaction with eosinophilia and systemic symptoms | 89.89 | 14.61 | 32 | 314206 | 28392 | 50262494 |
Haemorrhage | 89.86 | 14.61 | 120 | 314118 | 53321 | 50237565 |
Haematuria | 89.69 | 14.61 | 24 | 314214 | 25589 | 50265297 |
Product prescribing error | 89.58 | 14.61 | 12 | 314226 | 20949 | 50269937 |
Hallucination, visual | 89.38 | 14.61 | 3 | 314235 | 16579 | 50274307 |
Speech disorder | 89.35 | 14.61 | 55 | 314183 | 35493 | 50255393 |
Accidental overdose | 88.90 | 14.61 | 9 | 314229 | 19524 | 50271362 |
Physical disability | 88.82 | 14.61 | 81 | 314157 | 1766 | 50289120 |
Chronic kidney disease | 88.76 | 14.61 | 70 | 314168 | 39701 | 50251185 |
Respiratory distress | 88.75 | 14.61 | 39 | 314199 | 30450 | 50260436 |
Hepatic failure | 88.27 | 14.61 | 45 | 314193 | 32238 | 50258648 |
Arrhythmia | 87.92 | 14.61 | 48 | 314190 | 33084 | 50257802 |
White blood cell count decreased | 87.79 | 14.61 | 399 | 313839 | 116323 | 50174563 |
Joint range of motion decreased | 86.96 | 14.61 | 283 | 313955 | 18229 | 50272657 |
Dry skin | 86.74 | 14.61 | 84 | 314154 | 43107 | 50247779 |
Rheumatoid factor negative | 86.17 | 14.61 | 51 | 314187 | 549 | 50290337 |
Pollakiuria | 86.11 | 14.61 | 21 | 314217 | 23830 | 50267056 |
Acute myocardial infarction | 85.91 | 14.61 | 37 | 314201 | 29236 | 50261650 |
Bone density decreased | 84.45 | 14.61 | 202 | 314036 | 10873 | 50280013 |
Circulatory collapse | 84.17 | 14.61 | 12 | 314226 | 19988 | 50270898 |
Altered state of consciousness | 83.72 | 14.61 | 17 | 314221 | 21893 | 50268993 |
Caesarean section | 83.69 | 14.61 | 3 | 314235 | 15636 | 50275250 |
Renal disorder | 83.58 | 14.61 | 33 | 314205 | 27472 | 50263414 |
Full blood count decreased | 82.01 | 14.61 | 19 | 314219 | 22327 | 50268559 |
Diabetic ketoacidosis | 81.96 | 14.61 | 8 | 314230 | 17864 | 50273022 |
Haematochezia | 81.92 | 14.61 | 76 | 314162 | 39806 | 50251080 |
Device issue | 81.72 | 14.61 | 13 | 314225 | 19959 | 50270927 |
Ventricular tachycardia | 81.45 | 14.61 | 4 | 314234 | 15817 | 50275069 |
Grip strength decreased | 80.77 | 14.61 | 210 | 314028 | 11911 | 50278975 |
Thrombosis | 80.73 | 14.61 | 139 | 314099 | 55694 | 50235192 |
Ejection fraction decreased | 80.60 | 14.61 | 10 | 314228 | 18510 | 50272376 |
Withdrawal syndrome | 80.33 | 14.61 | 8 | 314230 | 17582 | 50273304 |
Dry mouth | 80.19 | 14.61 | 141 | 314097 | 56037 | 50234849 |
Metastases to bone | 80.09 | 14.61 | 9 | 314229 | 17986 | 50272900 |
Hemiparesis | 79.92 | 14.61 | 14 | 314224 | 20034 | 50270852 |
Haemophagocytic lymphohistiocytosis | 79.83 | 14.61 | 170 | 314068 | 8463 | 50282423 |
Surgical failure | 79.78 | 14.61 | 57 | 314181 | 864 | 50290022 |
Melaena | 78.77 | 14.61 | 34 | 314204 | 26830 | 50264056 |
Angioedema | 78.33 | 14.61 | 71 | 314167 | 37605 | 50253281 |
Mental disorder | 78.16 | 14.61 | 20 | 314218 | 21971 | 50268915 |
Cholestasis | 77.97 | 14.61 | 30 | 314208 | 25371 | 50265515 |
Wheezing | 77.92 | 14.61 | 168 | 314070 | 61879 | 50229007 |
Blood creatine phosphokinase increased | 77.90 | 14.61 | 33 | 314205 | 26334 | 50264552 |
Pericardial effusion | 77.26 | 14.61 | 31 | 314207 | 25558 | 50265328 |
Spinal column injury | 76.99 | 14.61 | 74 | 314164 | 1728 | 50289158 |
Unevaluable event | 76.88 | 14.61 | 104 | 314134 | 45962 | 50244924 |
Blood pressure fluctuation | 76.59 | 14.61 | 431 | 313807 | 35392 | 50255494 |
Toothache | 76.43 | 14.61 | 255 | 313983 | 16639 | 50274247 |
Abortion spontaneous | 76.31 | 14.61 | 88 | 314150 | 41684 | 50249202 |
Full blood count abnormal | 76.27 | 14.61 | 25 | 314213 | 23363 | 50267523 |
Cardiomegaly | 76.21 | 14.61 | 6 | 314232 | 15939 | 50274947 |
Malaise | 76.08 | 14.61 | 1548 | 312690 | 333984 | 49956902 |
Vaginal haemorrhage | 75.35 | 14.61 | 29 | 314209 | 24522 | 50266364 |
Transient ischaemic attack | 75.34 | 14.61 | 54 | 314184 | 32156 | 50258730 |
Onychomycosis | 75.26 | 14.61 | 122 | 314116 | 4920 | 50285966 |
Blood creatinine increased | 75.08 | 14.61 | 233 | 314005 | 75927 | 50214959 |
Respiratory disorder | 73.96 | 14.61 | 386 | 313852 | 30801 | 50260085 |
Colitis | 73.87 | 14.61 | 78 | 314160 | 38451 | 50252435 |
Haematemesis | 73.81 | 14.61 | 40 | 314198 | 27685 | 50263201 |
Ulcer | 73.56 | 14.61 | 284 | 313954 | 19916 | 50270970 |
Acute respiratory failure | 73.08 | 14.61 | 44 | 314194 | 28738 | 50262148 |
Electrolyte imbalance | 72.96 | 14.61 | 10 | 314228 | 17159 | 50273727 |
Injection site pruritus | 72.89 | 14.61 | 86 | 314152 | 40325 | 50250561 |
Gamma-glutamyltransferase increased | 72.85 | 14.61 | 47 | 314191 | 29576 | 50261310 |
Food allergy | 72.68 | 14.61 | 158 | 314080 | 7979 | 50282907 |
Myocardial infarction | 72.65 | 14.61 | 295 | 313943 | 88732 | 50202154 |
Visual acuity reduced | 72.18 | 14.61 | 18 | 314220 | 20121 | 50270765 |
Injection site swelling | 72.08 | 14.61 | 92 | 314146 | 41681 | 50249205 |
Tubulointerstitial nephritis | 71.93 | 14.61 | 6 | 314232 | 15205 | 50275681 |
Obstructive airways disorder | 71.79 | 14.61 | 7 | 314231 | 15645 | 50275241 |
Nightmare | 71.70 | 14.61 | 8 | 314230 | 16078 | 50274808 |
Blood pressure diastolic increased | 71.65 | 14.61 | 149 | 314089 | 7294 | 50283592 |
Rash macular | 71.52 | 14.61 | 16 | 314222 | 19261 | 50271625 |
Musculoskeletal disorder | 70.77 | 14.61 | 253 | 313985 | 17096 | 50273790 |
Therapeutic response unexpected | 70.73 | 14.61 | 8 | 314230 | 15907 | 50274979 |
Cerebral haemorrhage | 70.61 | 14.61 | 40 | 314198 | 27012 | 50263874 |
Nervousness | 70.59 | 14.61 | 42 | 314196 | 27609 | 50263277 |
Vertigo | 70.49 | 14.61 | 134 | 314104 | 51698 | 50239188 |
Device dislocation | 70.31 | 14.61 | 23 | 314215 | 21523 | 50269363 |
Haematocrit decreased | 70.26 | 14.61 | 68 | 314170 | 34908 | 50255978 |
Hypersomnia | 69.84 | 14.61 | 7 | 314231 | 15307 | 50275579 |
Staphylococcal infection | 69.53 | 14.61 | 71 | 314167 | 35545 | 50255341 |
Joint injury | 69.51 | 14.61 | 294 | 313944 | 21495 | 50269391 |
Atelectasis | 68.12 | 14.61 | 15 | 314223 | 18255 | 50272631 |
Colitis microscopic | 68.08 | 14.61 | 135 | 314103 | 6385 | 50284501 |
Pulmonary arterial hypertension | 67.54 | 14.61 | 21 | 314217 | 20298 | 50270588 |
Pancreatitis | 67.35 | 14.61 | 100 | 314138 | 42514 | 50248372 |
Blood lactate dehydrogenase increased | 67.24 | 14.61 | 19 | 314219 | 19543 | 50271343 |
Arthrodesis | 67.09 | 14.61 | 80 | 314158 | 2405 | 50288481 |
Vascular access complication | 67.08 | 14.61 | 56 | 314182 | 1080 | 50289806 |
Feeling hot | 66.95 | 14.61 | 87 | 314151 | 39115 | 50251771 |
Influenza like illness | 66.95 | 14.61 | 162 | 314076 | 57297 | 50233589 |
COVID-19 | 66.70 | 14.61 | 117 | 314121 | 46545 | 50244341 |
Red cell distribution width decreased | 66.34 | 14.61 | 55 | 314183 | 1050 | 50289836 |
Impaired work ability | 66.32 | 14.61 | 211 | 314027 | 13429 | 50277457 |
Mean platelet volume decreased | 65.61 | 14.61 | 65 | 314173 | 1577 | 50289309 |
Eating disorder | 65.42 | 14.61 | 9 | 314229 | 15400 | 50275486 |
Small intestinal obstruction | 64.53 | 14.61 | 11 | 314227 | 16057 | 50274829 |
Product administration error | 64.33 | 14.61 | 21 | 314217 | 19678 | 50271208 |
Rheumatoid lung | 64.33 | 14.61 | 78 | 314160 | 2387 | 50288499 |
Cardiac disorder | 63.98 | 14.61 | 105 | 314133 | 42874 | 50248012 |
Infusion site pain | 63.95 | 14.61 | 3 | 314235 | 12343 | 50278543 |
Blood glucose decreased | 63.88 | 14.61 | 17 | 314221 | 18194 | 50272692 |
Epilepsy | 63.70 | 14.61 | 27 | 314211 | 21540 | 50269346 |
Ataxia | 63.67 | 14.61 | 6 | 314232 | 13780 | 50277106 |
Hyperhidrosis | 63.53 | 14.61 | 312 | 313926 | 89114 | 50201772 |
Night sweats | 63.42 | 14.61 | 391 | 313847 | 33183 | 50257703 |
Muscle twitching | 63.23 | 14.61 | 10 | 314228 | 15421 | 50275465 |
Neutropenic sepsis | 63.15 | 14.61 | 7 | 314231 | 14140 | 50276746 |
Bedridden | 63.15 | 14.61 | 163 | 314075 | 9204 | 50281682 |
Lymphocyte count decreased | 62.99 | 14.61 | 43 | 314195 | 26264 | 50264622 |
Loose body in joint | 62.28 | 14.61 | 55 | 314183 | 1148 | 50289738 |
Diplopia | 62.08 | 14.61 | 21 | 314217 | 19239 | 50271647 |
Demyelination | 62.00 | 14.61 | 124 | 314114 | 5902 | 50284984 |
Urinary incontinence | 61.26 | 14.61 | 51 | 314187 | 28157 | 50262729 |
Lip swelling | 61.16 | 14.61 | 39 | 314199 | 24697 | 50266189 |
Osteoporotic fracture | 61.03 | 14.61 | 86 | 314152 | 3059 | 50287827 |
Intestinal obstruction | 60.70 | 14.61 | 45 | 314193 | 26338 | 50264548 |
Upper gastrointestinal haemorrhage | 60.12 | 14.61 | 13 | 314225 | 16022 | 50274864 |
Exposure during pregnancy | 60.09 | 14.61 | 472 | 313766 | 120543 | 50170343 |
Clostridium difficile colitis | 59.57 | 14.61 | 18 | 314220 | 17724 | 50273162 |
Myelosuppression | 59.56 | 14.61 | 7 | 314231 | 13510 | 50277376 |
Migraine | 59.21 | 14.61 | 253 | 313985 | 75027 | 50215859 |
Heart rate decreased | 59.15 | 14.61 | 409 | 313829 | 36088 | 50254798 |
Hypothermia | 58.92 | 14.61 | 4 | 314234 | 12012 | 50278874 |
Haemoptysis | 58.35 | 14.61 | 44 | 314194 | 25529 | 50265357 |
Tricuspid valve incompetence | 57.82 | 14.61 | 6 | 314232 | 12764 | 50278122 |
Premature baby | 57.38 | 14.61 | 21 | 314217 | 18316 | 50272570 |
Pharyngitis | 57.26 | 14.61 | 238 | 314000 | 17265 | 50273621 |
Antibody test positive | 56.88 | 14.61 | 71 | 314167 | 2240 | 50288646 |
Red blood cell count decreased | 56.85 | 14.61 | 76 | 314162 | 33759 | 50257127 |
Eye swelling | 56.71 | 14.61 | 27 | 314211 | 20117 | 50270769 |
Neutrophil count decreased | 56.65 | 14.61 | 126 | 314112 | 45900 | 50244986 |
Oral herpes | 56.58 | 14.61 | 267 | 313971 | 20458 | 50270428 |
Mitral valve incompetence | 56.40 | 14.61 | 19 | 314219 | 17452 | 50273434 |
Tachypnoea | 56.34 | 14.61 | 11 | 314227 | 14566 | 50276320 |
Sinus disorder | 56.32 | 14.61 | 22 | 314216 | 18436 | 50272450 |
Acute hepatic failure | 56.21 | 14.61 | 14 | 314224 | 15663 | 50275223 |
Anal incontinence | 55.83 | 14.61 | 4 | 314234 | 11486 | 50279400 |
Dystonia | 55.59 | 14.61 | 5 | 314233 | 11921 | 50278965 |
Adverse event | 55.52 | 14.61 | 463 | 313775 | 43300 | 50247586 |
Pallor | 55.44 | 14.61 | 38 | 314200 | 23161 | 50267725 |
Sinus bradycardia | 55.27 | 14.61 | 8 | 314230 | 13175 | 50277711 |
Clostridium difficile infection | 55.23 | 14.61 | 46 | 314192 | 25393 | 50265493 |
Device malfunction | 55.20 | 14.61 | 13 | 314225 | 15108 | 50275778 |
Cutaneous vasculitis | 55.12 | 14.61 | 98 | 314140 | 4264 | 50286622 |
Herpes zoster | 55.05 | 14.61 | 677 | 313561 | 70109 | 50220777 |
Retinal toxicity | 54.99 | 14.61 | 51 | 314187 | 1137 | 50289749 |
Frequent bowel movements | 54.87 | 14.61 | 10 | 314228 | 13908 | 50276978 |
Multiple organ dysfunction syndrome | 54.72 | 14.61 | 147 | 314091 | 50190 | 50240696 |
Infusion site reaction | 54.66 | 14.61 | 68 | 314170 | 2138 | 50288748 |
Bursitis | 54.59 | 14.61 | 277 | 313961 | 21858 | 50269028 |
Injection site mass | 54.32 | 14.61 | 15 | 314223 | 15665 | 50275221 |
Contusion | 54.01 | 14.61 | 988 | 313250 | 111195 | 50179691 |
Premature delivery | 53.62 | 14.61 | 41 | 314197 | 23622 | 50267264 |
Cyanosis | 53.60 | 14.61 | 14 | 314224 | 15170 | 50275716 |
Metastases to liver | 53.52 | 14.61 | 29 | 314209 | 20075 | 50270811 |
Gastritis | 53.50 | 14.61 | 76 | 314162 | 32907 | 50257979 |
Blood albumin decreased | 53.29 | 14.61 | 9 | 314229 | 13227 | 50277659 |
Limb mass | 53.17 | 14.61 | 74 | 314164 | 2601 | 50288285 |
Hyperlipidaemia | 53.11 | 14.61 | 21 | 314217 | 17469 | 50273417 |
Mood altered | 52.97 | 14.61 | 8 | 314230 | 12765 | 50278121 |
Flatulence | 52.79 | 14.61 | 63 | 314175 | 29395 | 50261491 |
Injection site warmth | 52.48 | 14.61 | 11 | 314227 | 13855 | 50277031 |
Mania | 52.47 | 14.61 | 4 | 314234 | 10912 | 50279974 |
Dementia | 52.34 | 14.61 | 17 | 314221 | 15980 | 50274906 |
Fear | 52.15 | 14.61 | 13 | 314225 | 14536 | 50276350 |
Oesophagitis | 51.94 | 14.61 | 10 | 314228 | 13373 | 50277513 |
Right ventricular failure | 51.80 | 14.61 | 17 | 314221 | 15876 | 50275010 |
Anuria | 51.65 | 14.61 | 5 | 314233 | 11239 | 50279647 |
Faeces discoloured | 51.25 | 14.61 | 18 | 314220 | 16106 | 50274780 |
Blood magnesium decreased | 51.16 | 14.61 | 5 | 314233 | 11155 | 50279731 |
Ageusia | 51.03 | 14.61 | 6 | 314232 | 11577 | 50279309 |
Renal tubular necrosis | 51.01 | 14.61 | 3 | 314235 | 10165 | 50280721 |
Finger deformity | 50.37 | 14.61 | 110 | 314128 | 5572 | 50285314 |
Fine motor skill dysfunction | 50.33 | 14.61 | 91 | 314147 | 4012 | 50286874 |
Cardiogenic shock | 50.29 | 14.61 | 17 | 314221 | 15582 | 50275304 |
Disability | 50.15 | 14.61 | 184 | 314054 | 12591 | 50278295 |
Face oedema | 50.08 | 14.61 | 24 | 314214 | 17815 | 50273071 |
Systemic lupus erythematosus rash | 49.87 | 14.61 | 58 | 314180 | 1697 | 50289189 |
Haematoma | 49.78 | 14.61 | 70 | 314168 | 30440 | 50260446 |
Swelling face | 49.67 | 14.61 | 164 | 314074 | 52431 | 50238455 |
Myelodysplastic syndrome | 49.65 | 14.61 | 16 | 314222 | 15116 | 50275770 |
Presbyacusis | 49.61 | 14.61 | 73 | 314165 | 2703 | 50288183 |
X-ray abnormal | 49.22 | 14.61 | 71 | 314167 | 2581 | 50288305 |
Diverticular perforation | 49.12 | 14.61 | 78 | 314160 | 3090 | 50287796 |
Joint arthroplasty | 48.73 | 14.61 | 63 | 314175 | 2060 | 50288826 |
Polyarthritis | 48.43 | 14.61 | 133 | 314105 | 7794 | 50283092 |
Transaminases abnormal | 48.41 | 14.61 | 35 | 314203 | 541 | 50290345 |
Nodule | 47.85 | 14.61 | 221 | 314017 | 16782 | 50274104 |
Delusion | 47.76 | 14.61 | 5 | 314233 | 10564 | 50280322 |
Coagulopathy | 47.60 | 14.61 | 26 | 314212 | 17918 | 50272968 |
Leukocytosis | 47.59 | 14.61 | 42 | 314196 | 22537 | 50268349 |
Retching | 47.07 | 14.61 | 11 | 314227 | 12851 | 50278035 |
Asthma | 46.91 | 14.61 | 343 | 313895 | 88994 | 50201892 |
Myocardial ischaemia | 46.53 | 14.61 | 8 | 314230 | 11605 | 50279281 |
Agranulocytosis | 46.18 | 14.61 | 39 | 314199 | 21382 | 50269504 |
Acute myeloid leukaemia | 45.94 | 14.61 | 18 | 314220 | 15056 | 50275830 |
Neurotoxicity | 45.92 | 14.61 | 17 | 314221 | 14723 | 50276163 |
Multiple sclerosis | 45.81 | 14.61 | 36 | 314202 | 20457 | 50270429 |
Premature labour | 45.77 | 14.61 | 8 | 314230 | 11468 | 50279418 |
White blood cell count abnormal | 45.62 | 14.61 | 103 | 314135 | 5337 | 50285549 |
Gastrointestinal perforation | 45.60 | 14.61 | 74 | 314164 | 2987 | 50287899 |
Hypercholesterolaemia | 45.47 | 14.61 | 168 | 314070 | 11535 | 50279351 |
Peptic ulcer haemorrhage | 45.37 | 14.61 | 43 | 314195 | 986 | 50289900 |
Mean cell volume decreased | 45.35 | 14.61 | 68 | 314170 | 2561 | 50288325 |
Weight decreased | 45.34 | 14.61 | 1037 | 313201 | 220208 | 50070678 |
Oedema | 45.27 | 14.61 | 253 | 313985 | 69928 | 50220958 |
Soft tissue disorder | 44.90 | 14.61 | 88 | 314150 | 4126 | 50286760 |
Multiple fractures | 44.52 | 14.61 | 115 | 314123 | 6496 | 50284390 |
Brain oedema | 44.44 | 14.61 | 11 | 314227 | 12359 | 50278527 |
Macular degeneration | 44.14 | 14.61 | 17 | 314221 | 14371 | 50276515 |
Hypovolaemia | 44.03 | 14.61 | 4 | 314234 | 9461 | 50281425 |
Body temperature decreased | 43.87 | 14.61 | 210 | 314028 | 16185 | 50274701 |
Hypokinesia | 43.63 | 14.61 | 11 | 314227 | 12206 | 50278680 |
Progressive multifocal leukoencephalopathy | 43.54 | 14.61 | 9 | 314229 | 11448 | 50279438 |
Abortion induced | 43.33 | 14.61 | 4 | 314234 | 9340 | 50281546 |
Pleural thickening | 43.10 | 14.61 | 66 | 314172 | 2533 | 50288353 |
Ventricular fibrillation | 42.91 | 14.61 | 7 | 314231 | 10552 | 50280334 |
Aspiration | 42.87 | 14.61 | 4 | 314234 | 9260 | 50281626 |
Glaucoma | 42.76 | 14.61 | 202 | 314036 | 15484 | 50275402 |
Cholecystitis chronic | 42.62 | 14.61 | 5 | 314233 | 9664 | 50281222 |
Glomerular filtration rate decreased | 42.57 | 14.61 | 10 | 314228 | 11642 | 50279244 |
Lung infiltration | 42.48 | 14.61 | 15 | 314223 | 13378 | 50277508 |
Iron deficiency anaemia | 42.37 | 14.61 | 26 | 314212 | 16808 | 50274078 |
Hypocalcaemia | 42.30 | 14.61 | 63 | 314175 | 26753 | 50264133 |
Cardiomyopathy | 42.20 | 14.61 | 22 | 314216 | 15564 | 50275322 |
Urine output decreased | 42.15 | 14.61 | 7 | 314231 | 10414 | 50280472 |
Hepatocellular injury | 41.87 | 14.61 | 60 | 314178 | 25887 | 50264999 |
Renal injury | 41.83 | 14.61 | 3 | 314235 | 8608 | 50282278 |
Joint effusion | 41.77 | 14.61 | 176 | 314062 | 12845 | 50278041 |
Ankle arthroplasty | 41.53 | 14.61 | 43 | 314195 | 1101 | 50289785 |
Pleural fibrosis | 41.44 | 14.61 | 75 | 314163 | 3309 | 50287577 |
Eosinophilia | 41.40 | 14.61 | 33 | 314205 | 18619 | 50272267 |
Eczema | 41.27 | 14.61 | 48 | 314190 | 22654 | 50268232 |
Exostosis | 40.94 | 14.61 | 162 | 314076 | 11491 | 50279395 |
Status epilepticus | 40.87 | 14.61 | 16 | 314222 | 13390 | 50277496 |
Pancreatitis acute | 40.50 | 14.61 | 53 | 314185 | 23759 | 50267127 |
Shock | 40.49 | 14.61 | 41 | 314197 | 20609 | 50270277 |
Left ventricular dysfunction | 40.46 | 14.61 | 8 | 314230 | 10498 | 50280388 |
Wheelchair user | 40.43 | 14.61 | 93 | 314145 | 4879 | 50286007 |
Growth failure | 39.59 | 14.61 | 25 | 314213 | 305 | 50290581 |
Dermatitis allergic | 39.31 | 14.61 | 170 | 314068 | 12550 | 50278336 |
Complication associated with device | 39.22 | 14.61 | 21 | 314217 | 14634 | 50276252 |
Malignant melanoma | 39.19 | 14.61 | 145 | 314093 | 9963 | 50280923 |
Cold sweat | 39.16 | 14.61 | 9 | 314229 | 10635 | 50280251 |
Hypotonia | 39.04 | 14.61 | 3 | 314235 | 8131 | 50282755 |
Concomitant disease aggravated | 38.79 | 14.61 | 3 | 314235 | 8088 | 50282798 |
Escherichia infection | 38.78 | 14.61 | 10 | 314228 | 10931 | 50279955 |
Sleep apnoea syndrome | 38.70 | 14.61 | 55 | 314183 | 23813 | 50267073 |
Subdural haematoma | 38.57 | 14.61 | 16 | 314222 | 12931 | 50277955 |
Toxic skin eruption | 38.54 | 14.61 | 11 | 314227 | 11240 | 50279646 |
Renal impairment | 38.52 | 14.61 | 293 | 313945 | 75368 | 50215518 |
Acute generalised exanthematous pustulosis | 38.47 | 14.61 | 5 | 314233 | 8933 | 50281953 |
Haemodynamic instability | 38.40 | 14.61 | 3 | 314235 | 8021 | 50282865 |
Head injury | 38.31 | 14.61 | 56 | 314182 | 23964 | 50266922 |
Injection site urticaria | 38.21 | 14.61 | 14 | 314224 | 12203 | 50278683 |
Interstitial lung disease | 38.12 | 14.61 | 501 | 313737 | 52675 | 50238211 |
Supraventricular tachycardia | 37.85 | 14.61 | 16 | 314222 | 12785 | 50278101 |
Paranoia | 37.57 | 14.61 | 9 | 314229 | 10339 | 50280547 |
Mean cell haemoglobin decreased | 37.37 | 14.61 | 71 | 314167 | 3252 | 50287634 |
Anger | 37.15 | 14.61 | 12 | 314226 | 11321 | 50279565 |
Device difficult to use | 37.09 | 14.61 | 8 | 314230 | 9878 | 50281008 |
Hepatitis | 36.86 | 14.61 | 327 | 313911 | 31126 | 50259760 |
Oliguria | 36.84 | 14.61 | 4 | 314234 | 8212 | 50282674 |
Sensory loss | 36.73 | 14.61 | 3 | 314235 | 7735 | 50283151 |
Blood calcium increased | 36.62 | 14.61 | 3 | 314235 | 7716 | 50283170 |
Nail disorder | 36.59 | 14.61 | 138 | 314100 | 9570 | 50281316 |
Vasculitic rash | 36.54 | 14.61 | 42 | 314196 | 1213 | 50289673 |
Aplastic anaemia | 36.53 | 14.61 | 3 | 314235 | 7700 | 50283186 |
Device related infection | 36.46 | 14.61 | 45 | 314193 | 20690 | 50270196 |
Localised infection | 36.35 | 14.61 | 277 | 313961 | 25208 | 50265678 |
Posterior reversible encephalopathy syndrome | 36.27 | 14.61 | 24 | 314214 | 14904 | 50275982 |
Hypercalcaemia | 36.26 | 14.61 | 259 | 313979 | 23093 | 50267793 |
Blood pressure abnormal | 36.01 | 14.61 | 17 | 314221 | 12730 | 50278156 |
Haemolytic anaemia | 35.94 | 14.61 | 7 | 314231 | 9285 | 50281601 |
Incorrect product administration duration | 35.85 | 14.61 | 7 | 314231 | 9268 | 50281618 |
Drug specific antibody | 35.55 | 14.61 | 50 | 314188 | 1775 | 50289111 |
Infiltration anaesthesia | 35.24 | 14.61 | 18 | 314220 | 141 | 50290745 |
Joint dislocation | 35.22 | 14.61 | 161 | 314077 | 12172 | 50278714 |
Atrial flutter | 35.19 | 14.61 | 6 | 314232 | 8757 | 50282129 |
Malnutrition | 35.15 | 14.61 | 19 | 314219 | 13170 | 50277716 |
Myopathy | 35.10 | 14.61 | 7 | 314231 | 9132 | 50281754 |
Infusion site erythema | 34.99 | 14.61 | 6 | 314232 | 8721 | 50282165 |
Hysterectomy | 34.98 | 14.61 | 4 | 314234 | 7886 | 50283000 |
Arthritis bacterial | 34.95 | 14.61 | 95 | 314143 | 5534 | 50285352 |
Pulmonary mass | 34.79 | 14.61 | 217 | 314021 | 18488 | 50272398 |
Schizophrenia | 34.75 | 14.61 | 3 | 314235 | 7394 | 50283492 |
Ventricular extrasystoles | 34.71 | 14.61 | 11 | 314227 | 10505 | 50280381 |
Feeling jittery | 34.55 | 14.61 | 13 | 314225 | 11147 | 50279739 |
Deafness | 34.53 | 14.61 | 28 | 314210 | 15663 | 50275223 |
Blood magnesium increased | 34.22 | 14.61 | 63 | 314175 | 2817 | 50288069 |
Panic attack | 33.99 | 14.61 | 42 | 314196 | 19300 | 50271586 |
Ileus | 33.90 | 14.61 | 20 | 314218 | 13209 | 50277677 |
Metastases to lung | 33.84 | 14.61 | 13 | 314225 | 11007 | 50279879 |
Oral candidiasis | 33.84 | 14.61 | 33 | 314205 | 16882 | 50274004 |
Rash papular | 33.82 | 14.61 | 18 | 314220 | 12586 | 50278300 |
Viral upper respiratory tract infection | 33.80 | 14.61 | 108 | 314130 | 6888 | 50283998 |
Ocular hyperaemia | 33.66 | 14.61 | 46 | 314192 | 20246 | 50270640 |
Intercepted product storage error | 33.40 | 14.61 | 12 | 314226 | 33 | 50290853 |
Flank pain | 33.36 | 14.61 | 20 | 314218 | 13095 | 50277791 |
Device breakage | 33.32 | 14.61 | 9 | 314229 | 9538 | 50281348 |
Mesenteritis | 33.20 | 14.61 | 17 | 314221 | 134 | 50290752 |
Central nervous system lesion | 33.02 | 14.61 | 9 | 314229 | 9480 | 50281406 |
Therapy non-responder | 32.62 | 14.61 | 471 | 313767 | 50551 | 50240335 |
Hypoaesthesia oral | 32.38 | 14.61 | 13 | 314225 | 10715 | 50280171 |
Skin papilloma | 32.10 | 14.61 | 77 | 314161 | 4152 | 50286734 |
Hemiplegia | 32.08 | 14.61 | 4 | 314234 | 7377 | 50283509 |
Ischaemic stroke | 32.03 | 14.61 | 31 | 314207 | 15917 | 50274969 |
Torus fracture | 32.02 | 14.61 | 16 | 314222 | 119 | 50290767 |
Pruritus allergic | 31.80 | 14.61 | 37 | 314201 | 1083 | 50289803 |
Haemorrhoids | 31.80 | 14.61 | 43 | 314195 | 19010 | 50271876 |
Extremity contracture | 31.77 | 14.61 | 39 | 314199 | 1209 | 50289677 |
Osteonecrosis | 31.69 | 14.61 | 57 | 314181 | 22460 | 50268426 |
Anti-cyclic citrullinated peptide antibody | 31.58 | 14.61 | 44 | 314194 | 1548 | 50289338 |
Drug resistance | 31.55 | 14.61 | 43 | 314195 | 18946 | 50271940 |
Adverse drug reaction | 31.52 | 14.61 | 500 | 313738 | 54722 | 50236164 |
Ankylosing spondylitis | 31.39 | 14.61 | 107 | 314131 | 7058 | 50283828 |
Nephropathy toxic | 31.16 | 14.61 | 6 | 314232 | 8023 | 50282863 |
Chromaturia | 30.92 | 14.61 | 27 | 314211 | 14563 | 50276323 |
Hot flush | 30.84 | 14.61 | 155 | 314083 | 44014 | 50246872 |
Femur fracture | 30.73 | 14.61 | 362 | 313876 | 37102 | 50253784 |
Taste disorder | 30.70 | 14.61 | 7 | 314231 | 8317 | 50282569 |
Apathy | 30.68 | 14.61 | 5 | 314233 | 7543 | 50283343 |
Breast cancer metastatic | 30.57 | 14.61 | 13 | 314225 | 10351 | 50280535 |
Paralysis | 30.56 | 14.61 | 8 | 314230 | 8656 | 50282230 |
Autoimmune hepatitis | 30.52 | 14.61 | 5 | 314233 | 7514 | 50283372 |
Illness | 30.34 | 14.61 | 67 | 314171 | 24473 | 50266413 |
Skin discolouration | 30.33 | 14.61 | 103 | 314135 | 32654 | 50258232 |
Hip fracture | 30.29 | 14.61 | 73 | 314165 | 25858 | 50265028 |
Rales | 30.27 | 14.61 | 12 | 314226 | 9966 | 50280920 |
Hypoacusis | 30.21 | 14.61 | 51 | 314187 | 20596 | 50270290 |
Peripheral sensory neuropathy | 30.09 | 14.61 | 3 | 314235 | 6588 | 50284298 |
Tumour lysis syndrome | 29.98 | 14.61 | 5 | 314233 | 7416 | 50283470 |
Injection site bruising | 29.88 | 14.61 | 122 | 314116 | 36646 | 50254240 |
Drug level decreased | 29.76 | 14.61 | 3 | 314235 | 6530 | 50284356 |
Underdose | 29.75 | 14.61 | 50 | 314188 | 20228 | 50270658 |
Injection site rash | 29.63 | 14.61 | 34 | 314204 | 16143 | 50274743 |
Pulmonary haemorrhage | 29.52 | 14.61 | 3 | 314235 | 6489 | 50284397 |
Pruritus | 29.36 | 14.61 | 2091 | 312147 | 281477 | 50009409 |
Paraesthesia oral | 29.22 | 14.61 | 20 | 314218 | 12201 | 50278685 |
Pre-eclampsia | 29.20 | 14.61 | 7 | 314231 | 8037 | 50282849 |
Motor dysfunction | 29.13 | 14.61 | 7 | 314231 | 8024 | 50282862 |
Liver injury | 29.12 | 14.61 | 258 | 313980 | 24548 | 50266338 |
Arteriosclerosis | 29.08 | 14.61 | 10 | 314228 | 9067 | 50281819 |
Deafness neurosensory | 28.99 | 14.61 | 77 | 314161 | 4424 | 50286462 |
Glycosylated haemoglobin increased | 28.67 | 14.61 | 15 | 314223 | 10591 | 50280295 |
Dermatitis contact | 28.62 | 14.61 | 9 | 314229 | 8637 | 50282249 |
Onychomadesis | 28.60 | 14.61 | 66 | 314172 | 3470 | 50287416 |
Bipolar disorder | 28.56 | 14.61 | 4 | 314234 | 6753 | 50284133 |
Cholelithiasis | 28.41 | 14.61 | 130 | 314108 | 37843 | 50253043 |
Cardiac failure acute | 28.38 | 14.61 | 8 | 314230 | 8242 | 50282644 |
Eructation | 28.32 | 14.61 | 5 | 314233 | 7116 | 50283770 |
Polyuria | 28.32 | 14.61 | 5 | 314233 | 7116 | 50283770 |
Skin burning sensation | 28.14 | 14.61 | 14 | 314224 | 10171 | 50280715 |
Hypoalbuminaemia | 28.09 | 14.61 | 13 | 314225 | 9847 | 50281039 |
Bundle branch block left | 28.02 | 14.61 | 3 | 314235 | 6227 | 50284659 |
Hypoaesthesia | 27.89 | 14.61 | 590 | 313648 | 126667 | 50164219 |
Productive cough | 27.80 | 14.61 | 202 | 314036 | 52492 | 50238394 |
Eyelid ptosis | 27.77 | 14.61 | 3 | 314235 | 6184 | 50284702 |
Gallbladder disorder | 27.72 | 14.61 | 38 | 314200 | 16704 | 50274182 |
Eyelid oedema | 27.72 | 14.61 | 12 | 314226 | 9454 | 50281432 |
Troponin increased | 27.69 | 14.61 | 8 | 314230 | 8110 | 50282776 |
Mood swings | 27.66 | 14.61 | 35 | 314203 | 15919 | 50274967 |
Graft versus host disease | 27.65 | 14.61 | 3 | 314235 | 6163 | 50284723 |
Thrombotic microangiopathy | 27.62 | 14.61 | 10 | 314228 | 8781 | 50282105 |
Genital haemorrhage | 27.53 | 14.61 | 4 | 314234 | 6570 | 50284316 |
Pelvic pain | 27.28 | 14.61 | 18 | 314220 | 11195 | 50279691 |
Intestinal sepsis | 27.27 | 14.61 | 18 | 314220 | 238 | 50290648 |
Liver disorder | 27.22 | 14.61 | 352 | 313886 | 36870 | 50254016 |
Heavy menstrual bleeding | 27.02 | 14.61 | 34 | 314204 | 15503 | 50275383 |
Major depression | 27.02 | 14.61 | 5 | 314233 | 6879 | 50284007 |
Juvenile idiopathic arthritis | 26.97 | 14.61 | 57 | 314181 | 2822 | 50288064 |
Electrocardiogram abnormal | 26.86 | 14.61 | 7 | 314231 | 7598 | 50283288 |
Device occlusion | 26.83 | 14.61 | 3 | 314235 | 6020 | 50284866 |
Pain of skin | 26.80 | 14.61 | 8 | 314230 | 7939 | 50282947 |
Lymphadenopathy | 26.69 | 14.61 | 112 | 314126 | 33387 | 50257499 |
Injection site haemorrhage | 26.62 | 14.61 | 58 | 314180 | 21288 | 50269598 |
Prosthesis user | 26.57 | 14.61 | 12 | 314226 | 69 | 50290817 |
Throat tightness | 26.54 | 14.61 | 56 | 314182 | 20791 | 50270095 |
Intestinal perforation | 26.45 | 14.61 | 132 | 314106 | 10347 | 50280539 |
Skin plaque | 26.16 | 14.61 | 4 | 314234 | 6324 | 50284562 |
Injection site hypersensitivity | 26.11 | 14.61 | 43 | 314195 | 1757 | 50289129 |
Dysstasia | 26.08 | 14.61 | 44 | 314194 | 17775 | 50273111 |
Thirst | 26.04 | 14.61 | 17 | 314221 | 10633 | 50280253 |
Loss of consciousness | 25.83 | 14.61 | 474 | 313764 | 103879 | 50187007 |
Back pain | 25.81 | 14.61 | 1110 | 313128 | 218920 | 50071966 |
Metastases to lymph nodes | 25.72 | 14.61 | 6 | 314232 | 7018 | 50283868 |
Cytomegalovirus infection | 25.70 | 14.61 | 45 | 314193 | 17917 | 50272969 |
Tinnitus | 25.68 | 14.61 | 89 | 314149 | 28043 | 50262843 |
Vitamin D deficiency | 25.52 | 14.61 | 20 | 314218 | 11382 | 50279504 |
Hepatic encephalopathy | 25.50 | 14.61 | 14 | 314224 | 9622 | 50281264 |
Erythema | 25.44 | 14.61 | 703 | 313535 | 145711 | 50145175 |
Accident | 25.42 | 14.61 | 80 | 314158 | 5061 | 50285825 |
Hospice care | 25.40 | 14.61 | 3 | 314235 | 5769 | 50285117 |
Hiatus hernia | 25.31 | 14.61 | 47 | 314191 | 18297 | 50272589 |
Enthesopathy | 25.27 | 14.61 | 100 | 314138 | 7093 | 50283793 |
White blood cell count increased | 25.25 | 14.61 | 156 | 314082 | 42084 | 50248802 |
Orthopnoea | 24.93 | 14.61 | 3 | 314235 | 5686 | 50285200 |
Personality change | 24.68 | 14.61 | 3 | 314235 | 5642 | 50285244 |
Diabetic eye disease | 24.53 | 14.61 | 14 | 314224 | 140 | 50290746 |
Pseudomonas infection | 24.53 | 14.61 | 14 | 314224 | 9416 | 50281470 |
Brachiocephalic artery stenosis | 24.48 | 14.61 | 9 | 314229 | 27 | 50290859 |
Amenorrhoea | 24.46 | 14.61 | 11 | 314227 | 8473 | 50282413 |
Activated partial thromboplastin time prolonged | 24.39 | 14.61 | 5 | 314233 | 6397 | 50284489 |
Nystagmus | 24.20 | 14.61 | 3 | 314235 | 5558 | 50285328 |
Atrial septal defect | 24.06 | 14.61 | 5 | 314233 | 6336 | 50284550 |
Middle insomnia | 24.04 | 14.61 | 16 | 314222 | 9905 | 50280981 |
Angina unstable | 24.02 | 14.61 | 6 | 314232 | 6700 | 50284186 |
Congestive cardiomyopathy | 23.96 | 14.61 | 3 | 314235 | 5515 | 50285371 |
Polyneuropathy | 23.88 | 14.61 | 24 | 314214 | 12107 | 50278779 |
Shock haemorrhagic | 23.77 | 14.61 | 11 | 314227 | 8333 | 50282553 |
Thinking abnormal | 23.77 | 14.61 | 15 | 314223 | 9552 | 50281334 |
Hyperthermia | 23.77 | 14.61 | 9 | 314229 | 7687 | 50283199 |
Wrist surgery | 23.73 | 14.61 | 27 | 314211 | 771 | 50290115 |
Laboratory test abnormal | 23.57 | 14.61 | 70 | 314168 | 23138 | 50267748 |
Arteriosclerosis coronary artery | 23.46 | 14.61 | 9 | 314229 | 7627 | 50283259 |
Amylase increased | 23.46 | 14.61 | 3 | 314235 | 5427 | 50285459 |
Amyotrophic lateral sclerosis | 23.46 | 14.61 | 31 | 314207 | 1036 | 50289850 |
Drug tolerance | 23.30 | 14.61 | 76 | 314162 | 4900 | 50285986 |
Acute pulmonary oedema | 23.29 | 14.61 | 8 | 314230 | 7259 | 50283627 |
Second primary malignancy | 23.24 | 14.61 | 7 | 314231 | 6907 | 50283979 |
Expired product administered | 23.19 | 14.61 | 3 | 314235 | 5379 | 50285507 |
Aortic arteriosclerosis | 23.19 | 14.61 | 3 | 314235 | 5379 | 50285507 |
Stress cardiomyopathy | 23.09 | 14.61 | 10 | 314228 | 7877 | 50283009 |
Dizziness postural | 23.00 | 14.61 | 5 | 314233 | 6140 | 50284746 |
Pulseless electrical activity | 22.86 | 14.61 | 7 | 314231 | 6834 | 50284052 |
Splenomegaly | 22.84 | 14.61 | 16 | 314222 | 9644 | 50281242 |
Hepatomegaly | 22.84 | 14.61 | 20 | 314218 | 10773 | 50280113 |
Atrioventricular block | 22.81 | 14.61 | 6 | 314232 | 6472 | 50284414 |
Erythema multiforme | 22.74 | 14.61 | 14 | 314224 | 9036 | 50281850 |
Gestational diabetes | 22.61 | 14.61 | 9 | 314229 | 7456 | 50283430 |
Rash maculo-papular | 22.53 | 14.61 | 87 | 314151 | 26554 | 50264332 |
Injection site induration | 22.52 | 14.61 | 12 | 314226 | 8385 | 50282501 |
Bone cyst | 22.46 | 14.61 | 43 | 314195 | 1981 | 50288905 |
Oral discomfort | 22.41 | 14.61 | 104 | 314134 | 7913 | 50282973 |
Therapy change | 22.30 | 14.61 | 3 | 314235 | 5222 | 50285664 |
Product complaint | 22.21 | 14.61 | 23 | 314215 | 11443 | 50279443 |
Dislocation of vertebra | 22.14 | 14.61 | 55 | 314183 | 3032 | 50287854 |
Impaired gastric emptying | 22.13 | 14.61 | 110 | 314128 | 8608 | 50282278 |
Eye pain | 22.12 | 14.61 | 96 | 314142 | 28353 | 50262533 |
Lower limb fracture | 22.11 | 14.61 | 158 | 314080 | 14088 | 50276798 |
Rhinorrhoea | 22.10 | 14.61 | 209 | 314029 | 51374 | 50239512 |
Obesity | 22.09 | 14.61 | 179 | 314059 | 16596 | 50274290 |
Feeding disorder | 22.06 | 14.61 | 20 | 314218 | 10593 | 50280293 |
Nasal congestion | 21.95 | 14.61 | 207 | 314031 | 50913 | 50239973 |
Eye irritation | 21.85 | 14.61 | 46 | 314192 | 17094 | 50273792 |
Poor quality sleep | 21.79 | 14.61 | 44 | 314194 | 16602 | 50274284 |
Injection site reaction | 21.78 | 14.61 | 434 | 313804 | 49598 | 50241288 |
Device failure | 21.73 | 14.61 | 4 | 314234 | 5524 | 50285362 |
Initial insomnia | 21.68 | 14.61 | 3 | 314235 | 5112 | 50285774 |
Immune reconstitution inflammatory syndrome | 21.66 | 14.61 | 4 | 314234 | 5512 | 50285374 |
Respiration abnormal | 21.61 | 14.61 | 3 | 314235 | 5099 | 50285787 |
Tooth infection | 21.61 | 14.61 | 156 | 314082 | 13956 | 50276930 |
Acidosis | 21.58 | 14.61 | 19 | 314219 | 10208 | 50280678 |
Product label confusion | 21.52 | 14.61 | 21 | 314217 | 500 | 50290386 |
Extra dose administered | 21.47 | 14.61 | 3 | 314235 | 5073 | 50285813 |
Respiratory tract infection | 21.42 | 14.61 | 114 | 314124 | 31903 | 50258983 |
Purpura | 21.42 | 14.61 | 18 | 314220 | 9893 | 50280993 |
Skin reaction | 21.39 | 14.61 | 134 | 314104 | 11434 | 50279452 |
Odynophagia | 21.27 | 14.61 | 7 | 314231 | 6525 | 50284361 |
Eye pruritus | 21.21 | 14.61 | 28 | 314210 | 12506 | 50278380 |
Angina pectoris | 21.21 | 14.61 | 87 | 314151 | 26101 | 50264785 |
Coronary artery occlusion | 21.21 | 14.61 | 10 | 314228 | 7493 | 50283393 |
Abdominal pain lower | 21.12 | 14.61 | 67 | 314171 | 21689 | 50269197 |
Hyperventilation | 21.08 | 14.61 | 4 | 314234 | 5405 | 50285481 |
Intermenstrual bleeding | 20.99 | 14.61 | 8 | 314230 | 6806 | 50284080 |
Toe amputation | 20.98 | 14.61 | 40 | 314198 | 1837 | 50289049 |
Hepatitis cholestatic | 20.91 | 14.61 | 6 | 314232 | 6111 | 50284775 |
Amnesia | 20.87 | 14.61 | 165 | 314073 | 42095 | 50248791 |
Swollen tongue | 20.83 | 14.61 | 99 | 314139 | 28531 | 50262355 |
Hyperthyroidism | 20.81 | 14.61 | 27 | 314211 | 12148 | 50278738 |
Blood thyroid stimulating hormone increased | 20.78 | 14.61 | 6 | 314232 | 6086 | 50284800 |
Wrist deformity | 20.78 | 14.61 | 39 | 314199 | 1770 | 50289116 |
Rheumatoid vasculitis | 20.75 | 14.61 | 17 | 314221 | 319 | 50290567 |
Lymphopenia | 20.70 | 14.61 | 41 | 314197 | 15580 | 50275306 |
Drug dependence | 20.50 | 14.61 | 59 | 314179 | 19700 | 50271186 |
Sensory disturbance | 20.46 | 14.61 | 26 | 314212 | 11803 | 50279083 |
Metabolic disorder | 20.41 | 14.61 | 4 | 314234 | 5282 | 50285604 |
Lipase increased | 20.39 | 14.61 | 14 | 314224 | 8527 | 50282359 |
Normal newborn | 20.37 | 14.61 | 8 | 314230 | 6683 | 50284203 |
Partial seizures | 20.28 | 14.61 | 3 | 314235 | 4862 | 50286024 |
Monocyte count increased | 20.26 | 14.61 | 78 | 314160 | 5461 | 50285425 |
Adverse reaction | 20.16 | 14.61 | 106 | 314132 | 8480 | 50282406 |
Vaginal discharge | 20.16 | 14.61 | 4 | 314234 | 5236 | 50285650 |
Foetal death | 20.08 | 14.61 | 13 | 314225 | 8167 | 50282719 |
Generalised oedema | 20.01 | 14.61 | 34 | 314204 | 13697 | 50277189 |
Restless legs syndrome | 19.99 | 14.61 | 43 | 314195 | 15854 | 50275032 |
Onychoclasis | 19.92 | 14.61 | 4 | 314234 | 5192 | 50285694 |
Hypovolaemic shock | 19.87 | 14.61 | 4 | 314234 | 5184 | 50285702 |
Urine abnormality | 19.76 | 14.61 | 7 | 314231 | 6231 | 50284655 |
Photosensitivity reaction | 19.72 | 14.61 | 31 | 314207 | 12880 | 50278006 |
Sputum discoloured | 19.67 | 14.61 | 33 | 314205 | 13362 | 50277524 |
Pharyngeal abscess | 19.55 | 14.61 | 15 | 314223 | 255 | 50290631 |
Crohn's disease | 19.55 | 14.61 | 3 | 314235 | 4730 | 50286156 |
Body height decreased | 19.47 | 14.61 | 16 | 314222 | 8892 | 50281994 |
Androgenetic alopecia | 19.46 | 14.61 | 12 | 314226 | 140 | 50290746 |
Epigastric discomfort | 19.34 | 14.61 | 80 | 314158 | 5790 | 50285096 |
Urticaria | 19.34 | 14.61 | 987 | 313251 | 128574 | 50162312 |
Neck surgery | 19.29 | 14.61 | 34 | 314204 | 1469 | 50289417 |
Infected skin ulcer | 19.26 | 14.61 | 41 | 314197 | 2040 | 50288846 |
Asphyxia | 19.16 | 14.61 | 5 | 314233 | 5422 | 50285464 |
Refusal of treatment by patient | 19.14 | 14.61 | 4 | 314234 | 5049 | 50285837 |
Micturition urgency | 19.13 | 14.61 | 14 | 314224 | 8250 | 50282636 |
Tongue disorder | 19.11 | 14.61 | 110 | 314128 | 9106 | 50281780 |
Pancreatic toxicity | 19.04 | 14.61 | 7 | 314231 | 21 | 50290865 |
Bacteraemia | 19.02 | 14.61 | 38 | 314200 | 14395 | 50276491 |
Salt craving | 18.89 | 14.61 | 10 | 314228 | 85 | 50290801 |
Proctalgia | 18.87 | 14.61 | 4 | 314234 | 4999 | 50285887 |
Hepatic function abnormal | 18.86 | 14.61 | 122 | 314116 | 32559 | 50258327 |
Oesophageal candidiasis | 18.82 | 14.61 | 4 | 314234 | 4990 | 50285896 |
Rib fracture | 18.79 | 14.61 | 59 | 314179 | 19162 | 50271724 |
Cholecystectomy | 18.78 | 14.61 | 18 | 314220 | 9285 | 50281601 |
Tendon disorder | 18.70 | 14.61 | 74 | 314164 | 5248 | 50285638 |
Blood glucose abnormal | 18.69 | 14.61 | 9 | 314229 | 6663 | 50284223 |
Haemolysis | 18.64 | 14.61 | 7 | 314231 | 6009 | 50284877 |
Product use in unapproved indication | 18.63 | 14.61 | 562 | 313676 | 115257 | 50175629 |
Embolism | 18.62 | 14.61 | 10 | 314228 | 6958 | 50283928 |
Jaw disorder | 18.54 | 14.61 | 4 | 314234 | 4939 | 50285947 |
Secretion discharge | 18.47 | 14.61 | 114 | 314124 | 9677 | 50281209 |
Live birth | 18.41 | 14.61 | 169 | 314069 | 16239 | 50274647 |
Intervertebral disc compression | 18.40 | 14.61 | 26 | 314212 | 927 | 50289959 |
Rhinitis allergic | 18.29 | 14.61 | 11 | 314227 | 7189 | 50283697 |
Protein total decreased | 18.26 | 14.61 | 5 | 314233 | 5251 | 50285635 |
Klebsiella infection | 18.26 | 14.61 | 11 | 314227 | 7183 | 50283703 |
Blood disorder | 18.26 | 14.61 | 6 | 314232 | 5599 | 50285287 |
Head discomfort | 18.26 | 14.61 | 25 | 314213 | 10994 | 50279892 |
Lower gastrointestinal haemorrhage | 18.20 | 14.61 | 10 | 314228 | 6869 | 50284017 |
Neutrophil count increased | 18.18 | 14.61 | 38 | 314200 | 14157 | 50276729 |
Exercise tolerance decreased | 18.17 | 14.61 | 4 | 314234 | 4870 | 50286016 |
Herpes simplex | 18.11 | 14.61 | 11 | 314227 | 7151 | 50283735 |
Cerebral ischaemia | 18.09 | 14.61 | 7 | 314231 | 5901 | 50284985 |
Cerebral infarction | 17.98 | 14.61 | 71 | 314167 | 21533 | 50269353 |
Multiple system atrophy | 17.98 | 14.61 | 13 | 314225 | 201 | 50290685 |
Acute coronary syndrome | 17.94 | 14.61 | 19 | 314219 | 9355 | 50281531 |
Decreased activity | 17.90 | 14.61 | 5 | 314233 | 5182 | 50285704 |
Iron deficiency | 17.86 | 14.61 | 7 | 314231 | 5855 | 50285031 |
Faecaloma | 17.86 | 14.61 | 11 | 314227 | 7097 | 50283789 |
Squamous cell carcinoma of skin | 17.85 | 14.61 | 5 | 314233 | 5173 | 50285713 |
Heart rate irregular | 17.84 | 14.61 | 61 | 314177 | 19299 | 50271587 |
Abscess rupture | 17.81 | 14.61 | 14 | 314224 | 247 | 50290639 |
Procedural pain | 17.74 | 14.61 | 37 | 314201 | 13795 | 50277091 |
Gastropleural fistula | 17.71 | 14.61 | 8 | 314230 | 46 | 50290840 |
Spinal cord infection | 17.69 | 14.61 | 20 | 314218 | 567 | 50290319 |
Hyperbilirubinaemia | 17.65 | 14.61 | 20 | 314218 | 9550 | 50281336 |
Pain in jaw | 17.63 | 14.61 | 153 | 314085 | 38275 | 50252611 |
Vaginal haematoma | 17.57 | 14.61 | 11 | 314227 | 132 | 50290754 |
Metastasis | 17.56 | 14.61 | 3 | 314235 | 4372 | 50286514 |
Ear discomfort | 17.56 | 14.61 | 10 | 314228 | 6734 | 50284152 |
Emotional disorder | 17.53 | 14.61 | 29 | 314209 | 11807 | 50279079 |
Large intestine polyp | 17.53 | 14.61 | 12 | 314226 | 7320 | 50283566 |
Hereditary angioedema | 17.42 | 14.61 | 6 | 314232 | 5436 | 50285450 |
Rheumatic disorder | 17.39 | 14.61 | 33 | 314205 | 1510 | 50289376 |
Blood loss anaemia | 17.32 | 14.61 | 15 | 314223 | 8124 | 50282762 |
Intervertebral disc space narrowing | 17.27 | 14.61 | 25 | 314213 | 912 | 50289974 |
Post procedural haemorrhage | 17.25 | 14.61 | 12 | 314226 | 7258 | 50283628 |
Protein urine present | 17.09 | 14.61 | 6 | 314232 | 5371 | 50285515 |
Increased appetite | 17.09 | 14.61 | 16 | 314222 | 8345 | 50282541 |
Gait inability | 17.07 | 14.61 | 324 | 313914 | 36703 | 50254183 |
Gastric haemorrhage | 17.03 | 14.61 | 7 | 314231 | 5689 | 50285197 |
Spinal osteoarthritis | 16.99 | 14.61 | 39 | 314199 | 14053 | 50276833 |
Viral infection | 16.77 | 14.61 | 113 | 314125 | 29873 | 50261013 |
Candida infection | 16.73 | 14.61 | 82 | 314156 | 23441 | 50267445 |
Lacrimation increased | 16.72 | 14.61 | 52 | 314186 | 16940 | 50273946 |
Drug-induced liver injury | 16.67 | 14.61 | 104 | 314134 | 27991 | 50262895 |
Skin hyperpigmentation | 16.58 | 14.61 | 6 | 314232 | 5270 | 50285616 |
Abnormal faeces | 16.57 | 14.61 | 3 | 314235 | 4193 | 50286693 |
Disability assessment scale score decreased | 16.53 | 14.61 | 5 | 314233 | 6 | 50290880 |
Acute respiratory distress syndrome | 16.53 | 14.61 | 71 | 314167 | 21028 | 50269858 |
Lower respiratory tract congestion | 16.46 | 14.61 | 38 | 314200 | 1998 | 50288888 |
Alanine aminotransferase abnormal | 16.43 | 14.61 | 60 | 314178 | 4096 | 50286790 |
Sleep disorder due to a general medical condition | 16.41 | 14.61 | 13 | 314225 | 7358 | 50283528 |
Low birth weight baby | 16.37 | 14.61 | 8 | 314230 | 5873 | 50285013 |
Sudden death | 16.35 | 14.61 | 19 | 314219 | 8972 | 50281914 |
Normochromic normocytic anaemia | 16.30 | 14.61 | 3 | 314235 | 4143 | 50286743 |
Gastric disorder | 16.28 | 14.61 | 266 | 313972 | 29282 | 50261604 |
Tooth loss | 16.28 | 14.61 | 9 | 314229 | 6161 | 50284725 |
Bunion operation | 16.28 | 14.61 | 27 | 314211 | 1110 | 50289776 |
Neuralgia | 16.26 | 14.61 | 75 | 314163 | 21788 | 50269098 |
Infected bite | 16.24 | 14.61 | 30 | 314208 | 1345 | 50289541 |
Localised oedema | 16.23 | 14.61 | 5 | 314233 | 4862 | 50286024 |
Disseminated large cell lymphoma | 16.18 | 14.61 | 8 | 314230 | 58 | 50290828 |
Affective disorder | 16.10 | 14.61 | 6 | 314232 | 5175 | 50285711 |
Hypothyroidism | 16.05 | 14.61 | 135 | 314103 | 33990 | 50256896 |
Synovial cyst | 15.99 | 14.61 | 96 | 314142 | 8070 | 50282816 |
Needle issue | 15.98 | 14.61 | 13 | 314225 | 7262 | 50283624 |
Adenoiditis | 15.98 | 14.61 | 7 | 314231 | 37 | 50290849 |
Dermatitis exfoliative | 15.90 | 14.61 | 6 | 314232 | 5136 | 50285750 |
Blood urine present | 15.89 | 14.61 | 35 | 314203 | 12798 | 50278088 |
Escherichia urinary tract infection | 15.84 | 14.61 | 25 | 314213 | 10370 | 50280516 |
Dermatitis acneiform | 15.81 | 14.61 | 3 | 314235 | 4054 | 50286832 |
Mouth ulceration | 15.71 | 14.61 | 253 | 313985 | 27771 | 50263115 |
Eosinophil count increased | 15.70 | 14.61 | 19 | 314219 | 8811 | 50282075 |
Pulmonary alveolar haemorrhage | 15.65 | 14.61 | 3 | 314235 | 4024 | 50286862 |
Epstein-Barr viraemia | 15.60 | 14.61 | 23 | 314215 | 853 | 50290033 |
Mental fatigue | 15.54 | 14.61 | 15 | 314223 | 352 | 50290534 |
Azotaemia | 15.54 | 14.61 | 3 | 314235 | 4005 | 50286881 |
Dermatitis bullous | 15.53 | 14.61 | 13 | 314225 | 7160 | 50283726 |
Pleurisy | 15.53 | 14.61 | 88 | 314150 | 7243 | 50283643 |
Immune thrombocytopenia | 15.41 | 14.61 | 20 | 314218 | 8997 | 50281889 |
Hypofibrinogenaemia | 15.38 | 14.61 | 26 | 314212 | 1086 | 50289800 |
Effusion | 15.32 | 14.61 | 32 | 314206 | 1571 | 50289315 |
Heparin-induced thrombocytopenia | 15.31 | 14.61 | 3 | 314235 | 3962 | 50286924 |
Movement disorder | 15.29 | 14.61 | 57 | 314181 | 17575 | 50273311 |
Periorbital oedema | 15.25 | 14.61 | 6 | 314232 | 5006 | 50285880 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 15.23 | 14.61 | 40 | 314198 | 2282 | 50288604 |
Myositis | 15.22 | 14.61 | 16 | 314222 | 7904 | 50282982 |
Pneumonia fungal | 15.21 | 14.61 | 4 | 314234 | 4316 | 50286570 |
Gastric infection | 15.20 | 14.61 | 47 | 314191 | 2945 | 50287941 |
Post-traumatic stress disorder | 15.12 | 14.61 | 4 | 314234 | 4299 | 50286587 |
Anosmia | 15.12 | 14.61 | 3 | 314235 | 3928 | 50286958 |
Wound infection | 15.12 | 14.61 | 128 | 314110 | 12020 | 50278866 |
Bundle branch block right | 15.08 | 14.61 | 5 | 314233 | 4640 | 50286246 |
Coronary artery stenosis | 15.05 | 14.61 | 4 | 314234 | 4285 | 50286601 |
Intercepted medication error | 15.04 | 14.61 | 16 | 314222 | 423 | 50290463 |
Peroneal nerve palsy | 15.02 | 14.61 | 4 | 314234 | 4279 | 50286607 |
Aphthous ulcer | 15.01 | 14.61 | 115 | 314123 | 10482 | 50280404 |
Nephropathy | 14.87 | 14.61 | 7 | 314231 | 5251 | 50285635 |
Sexual abuse | 14.85 | 14.61 | 10 | 314228 | 137 | 50290749 |
Fluid retention | 14.85 | 14.61 | 223 | 314015 | 50426 | 50240460 |
Breast mass | 14.83 | 14.61 | 11 | 314227 | 6438 | 50284448 |
Proteinuria | 14.82 | 14.61 | 53 | 314185 | 16544 | 50274342 |
Petechiae | 14.79 | 14.61 | 35 | 314203 | 12477 | 50278409 |
Hepatitis C | 14.77 | 14.61 | 6 | 314232 | 4911 | 50285975 |
Retinal haemorrhage | 14.75 | 14.61 | 5 | 314233 | 4576 | 50286310 |
Premature rupture of membranes | 14.75 | 14.61 | 5 | 314233 | 4575 | 50286311 |
Fracture delayed union | 14.72 | 14.61 | 39 | 314199 | 2237 | 50288649 |
Breath sounds abnormal | 14.68 | 14.61 | 16 | 314222 | 7776 | 50283110 |
Infusion site extravasation | 14.67 | 14.61 | 13 | 314225 | 6963 | 50283923 |
Aplasia pure red cell | 14.66 | 14.61 | 4 | 314234 | 4211 | 50286675 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 1668.62 | 14.64 | 2620 | 51667 | 360550 | 29159690 |
Off label use | 1603.69 | 14.64 | 2328 | 51959 | 298472 | 29221768 |
Joint swelling | 1033.87 | 14.64 | 800 | 53487 | 48830 | 29471410 |
Intentional product use issue | 869.39 | 14.64 | 678 | 53609 | 41820 | 29478420 |
Contraindicated product administered | 771.99 | 14.64 | 457 | 53830 | 17809 | 29502431 |
Synovitis | 742.61 | 14.64 | 374 | 53913 | 10516 | 29509724 |
Rheumatoid arthritis | 637.79 | 14.64 | 504 | 53783 | 31648 | 29488592 |
Apparent death | 563.97 | 14.64 | 220 | 54067 | 3284 | 29516956 |
Treatment failure | 532.74 | 14.64 | 482 | 53805 | 36457 | 29483783 |
Bone erosion | 511.29 | 14.64 | 192 | 54095 | 2568 | 29517672 |
Diverticulitis | 505.79 | 14.64 | 346 | 53941 | 17358 | 29502882 |
Drug intolerance | 420.15 | 14.64 | 480 | 53807 | 47899 | 29472341 |
Arthropathy | 403.96 | 14.64 | 327 | 53960 | 21227 | 29499013 |
Therapeutic product effect decreased | 396.64 | 14.64 | 370 | 53917 | 29081 | 29491159 |
C-reactive protein abnormal | 386.36 | 14.64 | 204 | 54083 | 6332 | 29513908 |
No adverse event | 370.16 | 14.64 | 285 | 54002 | 17193 | 29503047 |
Red blood cell sedimentation rate abnormal | 336.98 | 14.64 | 135 | 54152 | 2168 | 29518072 |
Arthralgia | 334.71 | 14.64 | 769 | 53518 | 138848 | 29381392 |
Drug eruption | 317.90 | 14.64 | 256 | 54031 | 16485 | 29503755 |
Pain | 302.99 | 14.64 | 841 | 53446 | 170591 | 29349649 |
Stomatitis | 275.39 | 14.64 | 340 | 53947 | 36773 | 29483467 |
Urticaria | 264.13 | 14.64 | 407 | 53880 | 54253 | 29465987 |
Toxicity to various agents | 258.78 | 14.64 | 15 | 54272 | 173646 | 29346594 |
Red blood cell sedimentation rate increased | 222.90 | 14.64 | 150 | 54137 | 7311 | 29512929 |
Hypersensitivity | 212.08 | 14.64 | 362 | 53925 | 52541 | 29467699 |
Hepatic function abnormal | 206.16 | 14.64 | 304 | 53983 | 38955 | 29481285 |
Pain in extremity | 197.80 | 14.64 | 545 | 53742 | 109888 | 29410352 |
Drug hypersensitivity | 186.24 | 14.64 | 397 | 53890 | 68009 | 29452231 |
Rheumatoid factor negative | 176.78 | 14.64 | 64 | 54223 | 766 | 29519474 |
Peripheral swelling | 174.74 | 14.64 | 371 | 53916 | 63368 | 29456872 |
Diarrhoea | 168.53 | 14.64 | 219 | 54068 | 332479 | 29187761 |
Loss of personal independence in daily activities | 167.96 | 14.64 | 220 | 54067 | 25220 | 29495020 |
Pulmonary thrombosis | 165.67 | 14.64 | 119 | 54168 | 6446 | 29513794 |
Musculoskeletal stiffness | 164.35 | 14.64 | 267 | 54020 | 37191 | 29483049 |
Ill-defined disorder | 159.54 | 14.64 | 148 | 54139 | 11530 | 29508710 |
C-reactive protein increased | 153.04 | 14.64 | 284 | 54003 | 43979 | 29476261 |
Knee arthroplasty | 152.81 | 14.64 | 108 | 54179 | 5701 | 29514539 |
Anaemia | 147.05 | 14.64 | 94 | 54193 | 200857 | 29319383 |
Completed suicide | 147.00 | 14.64 | 4 | 54283 | 90242 | 29429998 |
Bone cyst | 144.15 | 14.64 | 50 | 54237 | 523 | 29519717 |
Mobility decreased | 137.25 | 14.64 | 201 | 54086 | 25579 | 29494661 |
Impaired work ability | 132.70 | 14.64 | 98 | 54189 | 5542 | 29514698 |
Terminal state | 128.35 | 14.64 | 80 | 54207 | 3414 | 29516826 |
Overdose | 124.81 | 14.64 | 5 | 54282 | 79814 | 29440426 |
Swelling | 122.71 | 14.64 | 227 | 54060 | 35056 | 29485184 |
Arthritis bacterial | 120.62 | 14.64 | 84 | 54203 | 4329 | 29515911 |
Anti-cyclic citrullinated peptide antibody positive | 119.49 | 14.64 | 48 | 54239 | 776 | 29519464 |
Acute kidney injury | 116.12 | 14.64 | 193 | 54094 | 265074 | 29255166 |
Epistaxis | 115.99 | 14.64 | 278 | 54009 | 51426 | 29468814 |
Drug specific antibody present | 115.75 | 14.64 | 67 | 54220 | 2494 | 29517746 |
Febrile neutropenia | 114.72 | 14.64 | 32 | 54255 | 112208 | 29408032 |
Fatigue | 111.60 | 14.64 | 262 | 54025 | 316559 | 29203681 |
Mass | 110.67 | 14.64 | 97 | 54190 | 7014 | 29513226 |
Interstitial lung disease | 108.27 | 14.64 | 290 | 53997 | 57428 | 29462812 |
Vomiting | 107.94 | 14.64 | 139 | 54148 | 212121 | 29308119 |
Deep vein thrombosis | 106.27 | 14.64 | 287 | 54000 | 57112 | 29463128 |
Confusional state | 106.19 | 14.64 | 51 | 54236 | 127826 | 29392414 |
Haemophagocytic lymphohistiocytosis | 106.18 | 14.64 | 113 | 54174 | 10391 | 29509849 |
Dehydration | 104.45 | 14.64 | 40 | 54247 | 114708 | 29405532 |
Herpes zoster | 104.05 | 14.64 | 193 | 54094 | 29859 | 29490381 |
Drug interaction | 103.75 | 14.64 | 126 | 54161 | 197259 | 29322981 |
Skin ulcer | 103.33 | 14.64 | 149 | 54138 | 18691 | 29501549 |
Infusion related reaction | 101.70 | 14.64 | 239 | 54048 | 43647 | 29476593 |
Pulmonary embolism | 99.59 | 14.64 | 338 | 53949 | 76196 | 29444044 |
Limb discomfort | 98.61 | 14.64 | 104 | 54183 | 9464 | 29510776 |
Hypofibrinogenaemia | 97.70 | 14.64 | 50 | 54237 | 1451 | 29518789 |
Joint ankylosis | 95.44 | 14.64 | 34 | 54253 | 387 | 29519853 |
Bladder transitional cell carcinoma | 92.04 | 14.64 | 57 | 54230 | 2404 | 29517836 |
Intestinal polyp | 88.72 | 14.64 | 40 | 54247 | 870 | 29519370 |
Gastric disorder | 85.70 | 14.64 | 102 | 54185 | 10602 | 29509638 |
Malignant neoplasm progression | 83.41 | 14.64 | 17 | 54270 | 73842 | 29446398 |
Joint lock | 83.36 | 14.64 | 41 | 54246 | 1091 | 29519149 |
Nasopharyngitis | 80.68 | 14.64 | 267 | 54020 | 59398 | 29460842 |
Death | 80.12 | 14.64 | 340 | 53947 | 341744 | 29178496 |
Nodule | 80.09 | 14.64 | 70 | 54217 | 5042 | 29515198 |
X-ray abnormal | 76.84 | 14.64 | 30 | 54257 | 448 | 29519792 |
Cytology abnormal | 74.69 | 14.64 | 28 | 54259 | 372 | 29519868 |
Physical disability | 73.68 | 14.64 | 39 | 54248 | 1215 | 29519025 |
Sleep disorder due to general medical condition, insomnia type | 72.98 | 14.64 | 39 | 54248 | 1239 | 29519001 |
Pyrexia | 72.23 | 14.64 | 278 | 54009 | 287344 | 29232896 |
Dyspnoea | 71.48 | 14.64 | 333 | 53954 | 326399 | 29193841 |
Blood pressure diastolic abnormal | 70.75 | 14.64 | 49 | 54238 | 2502 | 29517738 |
Dizziness | 70.56 | 14.64 | 152 | 54135 | 189532 | 29330708 |
Joint arthroplasty | 70.01 | 14.64 | 31 | 54256 | 645 | 29519595 |
Arthritis | 68.88 | 14.64 | 146 | 54141 | 24873 | 29495367 |
Asthenia | 68.63 | 14.64 | 187 | 54100 | 215063 | 29305177 |
Drug use disorder | 68.48 | 14.64 | 54 | 54233 | 3368 | 29516872 |
Hepatitis B virus test positive | 68.11 | 14.64 | 24 | 54263 | 264 | 29519976 |
Hyponatraemia | 67.73 | 14.64 | 20 | 54267 | 67613 | 29452627 |
Cardiac failure congestive | 65.91 | 14.64 | 29 | 54258 | 76552 | 29443688 |
Polyarthritis | 65.81 | 14.64 | 56 | 54231 | 3889 | 29516351 |
Constipation | 65.21 | 14.64 | 68 | 54219 | 114092 | 29406148 |
Hepatitis | 65.17 | 14.64 | 128 | 54159 | 20655 | 29499585 |
Decreased appetite | 65.06 | 14.64 | 104 | 54183 | 145238 | 29375002 |
Rheumatoid factor positive | 64.39 | 14.64 | 29 | 54258 | 629 | 29519611 |
Loss of consciousness | 62.24 | 14.64 | 29 | 54258 | 74027 | 29446213 |
Seizure | 62.11 | 14.64 | 48 | 54239 | 93075 | 29427165 |
Rhabdomyolysis | 60.86 | 14.64 | 18 | 54269 | 60790 | 29459450 |
Disability | 58.44 | 14.64 | 55 | 54232 | 4361 | 29515879 |
Hyperkalaemia | 58.19 | 14.64 | 20 | 54267 | 61372 | 29458868 |
Intestinal sepsis | 58.11 | 14.64 | 24 | 54263 | 418 | 29519822 |
Syncope | 58.11 | 14.64 | 39 | 54248 | 81332 | 29438908 |
Muscle spasms | 57.99 | 14.64 | 255 | 54032 | 64827 | 29455413 |
Rheumatoid nodule | 57.07 | 14.64 | 40 | 54247 | 2082 | 29518158 |
Joint stiffness | 56.49 | 14.64 | 78 | 54209 | 9395 | 29510845 |
Photosensitivity reaction | 56.37 | 14.64 | 77 | 54210 | 9181 | 29511059 |
Somnolence | 55.89 | 14.64 | 54 | 54233 | 93901 | 29426339 |
Hypokalaemia | 55.75 | 14.64 | 12 | 54275 | 50191 | 29470049 |
General physical health deterioration | 55.71 | 14.64 | 64 | 54223 | 102793 | 29417447 |
Alanine aminotransferase abnormal | 55.62 | 14.64 | 45 | 54242 | 2912 | 29517328 |
Skin laceration | 55.62 | 14.64 | 84 | 54203 | 10978 | 29509262 |
Drug effective for unapproved indication | 55.18 | 14.64 | 34 | 54253 | 1421 | 29518819 |
Blood pressure diastolic decreased | 54.71 | 14.64 | 66 | 54221 | 6956 | 29513284 |
Localised infection | 54.55 | 14.64 | 94 | 54193 | 13722 | 29506518 |
Depression | 54.15 | 14.64 | 46 | 54241 | 85101 | 29435139 |
Dysphagia | 53.62 | 14.64 | 17 | 54270 | 54909 | 29465331 |
Lymphoedema | 51.94 | 14.64 | 46 | 54241 | 3371 | 29516869 |
Gait inability | 51.47 | 14.64 | 108 | 54179 | 18267 | 29501973 |
Immune effector cell-associated neurotoxicity syndrome | 51.24 | 14.64 | 33 | 54254 | 1491 | 29518749 |
Prerenal failure | 51.13 | 14.64 | 35 | 54252 | 1753 | 29518487 |
Disability assessment scale score increased | 50.89 | 14.64 | 17 | 54270 | 157 | 29520083 |
Oxygen saturation decreased | 50.29 | 14.64 | 189 | 54098 | 44748 | 29475492 |
Malaise | 49.80 | 14.64 | 140 | 54147 | 159462 | 29360778 |
Fall | 49.18 | 14.64 | 164 | 54123 | 177014 | 29343226 |
Coma | 49.10 | 14.64 | 7 | 54280 | 39443 | 29480797 |
Hospitalisation | 49.05 | 14.64 | 12 | 54275 | 45976 | 29474264 |
Liver function test increased | 48.42 | 14.64 | 82 | 54205 | 11803 | 29508437 |
Immobile | 48.34 | 14.64 | 37 | 54250 | 2208 | 29518032 |
Vision blurred | 48.02 | 14.64 | 8 | 54279 | 40168 | 29480072 |
Osteolysis | 48.02 | 14.64 | 32 | 54255 | 1533 | 29518707 |
Skin mass | 47.71 | 14.64 | 44 | 54243 | 3399 | 29516841 |
Pulmonary fibrosis | 47.68 | 14.64 | 95 | 54192 | 15487 | 29504753 |
Gastrointestinal haemorrhage | 46.96 | 14.64 | 46 | 54241 | 79487 | 29440753 |
Seronegative arthritis | 46.68 | 14.64 | 26 | 54261 | 898 | 29519342 |
International normalised ratio increased | 46.51 | 14.64 | 12 | 54275 | 44360 | 29475880 |
Wrong technique in product usage process | 45.85 | 14.64 | 3 | 54284 | 31425 | 29488815 |
Incorrect dose administered | 45.71 | 14.64 | 4 | 54283 | 32980 | 29487260 |
Therapeutic product effect incomplete | 45.39 | 14.64 | 167 | 54120 | 39138 | 29481102 |
Plasma cell myeloma | 45.23 | 14.64 | 7 | 54280 | 37108 | 29483132 |
Blood pressure diastolic increased | 45.16 | 14.64 | 44 | 54243 | 3642 | 29516598 |
Bronchopulmonary aspergillosis | 44.88 | 14.64 | 81 | 54206 | 12263 | 29507977 |
Hip arthroplasty | 44.44 | 14.64 | 44 | 54243 | 3714 | 29516526 |
Suicidal ideation | 43.58 | 14.64 | 6 | 54281 | 34710 | 29485530 |
Oral surgery | 43.50 | 14.64 | 21 | 54266 | 536 | 29519704 |
Infection | 43.45 | 14.64 | 265 | 54022 | 76486 | 29443754 |
Anxiety | 43.17 | 14.64 | 56 | 54231 | 85309 | 29434931 |
Musculoskeletal pain | 43.13 | 14.64 | 134 | 54153 | 28819 | 29491421 |
Blood pressure systolic abnormal | 43.02 | 14.64 | 34 | 54253 | 2127 | 29518113 |
Product dose omission issue | 42.12 | 14.64 | 70 | 54217 | 96313 | 29423927 |
Hypoglycaemia | 42.07 | 14.64 | 18 | 54269 | 48328 | 29471912 |
Hallucination | 41.62 | 14.64 | 15 | 54272 | 44697 | 29475543 |
Depressed level of consciousness | 40.67 | 14.64 | 9 | 54278 | 36933 | 29483307 |
Abscess | 40.63 | 14.64 | 68 | 54219 | 9694 | 29510546 |
Drug tolerance decreased | 40.04 | 14.64 | 27 | 54260 | 1319 | 29518921 |
Soft tissue swelling | 39.90 | 14.64 | 17 | 54270 | 321 | 29519919 |
Medical device implantation | 39.89 | 14.64 | 20 | 54267 | 555 | 29519685 |
Dysarthria | 39.62 | 14.64 | 5 | 54282 | 30906 | 29489334 |
Mental status changes | 39.49 | 14.64 | 8 | 54279 | 34919 | 29485321 |
Juvenile idiopathic arthritis | 39.18 | 14.64 | 27 | 54260 | 1367 | 29518873 |
Atrial fibrillation | 38.92 | 14.64 | 85 | 54202 | 105561 | 29414679 |
Blood fibrinogen decreased | 38.80 | 14.64 | 23 | 54264 | 895 | 29519345 |
Blood glucose increased | 38.56 | 14.64 | 31 | 54256 | 58953 | 29461287 |
Abdominal distension | 38.53 | 14.64 | 18 | 54269 | 45893 | 29474347 |
Suicide attempt | 38.18 | 14.64 | 8 | 54279 | 34102 | 29486138 |
Haematuria | 37.51 | 14.64 | 17 | 54270 | 44122 | 29476118 |
Hand deformity | 37.10 | 14.64 | 31 | 54256 | 2099 | 29518141 |
Osteoarthritis | 37.01 | 14.64 | 94 | 54193 | 18009 | 29502231 |
Fine motor skill dysfunction | 36.59 | 14.64 | 27 | 54260 | 1524 | 29518716 |
Blood creatinine increased | 36.08 | 14.64 | 63 | 54224 | 85039 | 29435201 |
Agitation | 36.06 | 14.64 | 25 | 54262 | 51279 | 29468961 |
Cytokine release syndrome | 35.45 | 14.64 | 76 | 54211 | 13043 | 29507197 |
Aggression | 34.68 | 14.64 | 11 | 54276 | 35530 | 29484710 |
Lactic acidosis | 34.05 | 14.64 | 7 | 54280 | 30240 | 29490000 |
Poor venous access | 33.71 | 14.64 | 35 | 54252 | 3126 | 29517114 |
Disseminated mucormycosis | 33.07 | 14.64 | 15 | 54272 | 331 | 29519909 |
Myalgia | 32.11 | 14.64 | 54 | 54233 | 73965 | 29446275 |
Blood pressure systolic increased | 31.90 | 14.64 | 85 | 54202 | 16760 | 29503480 |
Abscess limb | 29.92 | 14.64 | 33 | 54254 | 3158 | 29517082 |
Hypotension | 29.61 | 14.64 | 222 | 54065 | 194132 | 29326108 |
Drug ineffective for unapproved indication | 29.26 | 14.64 | 74 | 54213 | 14140 | 29506100 |
Thrombocytopenia | 28.41 | 14.64 | 139 | 54148 | 134684 | 29385556 |
Amnesia | 28.21 | 14.64 | 4 | 54283 | 22639 | 29497601 |
Herpes simplex viraemia | 28.08 | 14.64 | 9 | 54278 | 72 | 29520168 |
Coronary artery disease | 27.92 | 14.64 | 24 | 54263 | 44166 | 29476074 |
Unresponsive to stimuli | 27.90 | 14.64 | 6 | 54281 | 25120 | 29495120 |
Hepatic steatosis | 27.88 | 14.64 | 75 | 54212 | 14871 | 29505369 |
Renal impairment | 27.88 | 14.64 | 68 | 54219 | 81265 | 29438975 |
Abdominal pain | 27.69 | 14.64 | 141 | 54146 | 135216 | 29385024 |
Pancytopenia | 27.37 | 14.64 | 71 | 54216 | 83097 | 29437143 |
Pulmonary toxicity | 27.28 | 14.64 | 39 | 54248 | 4851 | 29515389 |
Joint injury | 27.14 | 14.64 | 47 | 54240 | 6886 | 29513354 |
Infectious pleural effusion | 27.11 | 14.64 | 25 | 54262 | 1931 | 29518309 |
Haematemesis | 27.10 | 14.64 | 6 | 54281 | 24620 | 29495620 |
Interleukin level increased | 27.05 | 14.64 | 9 | 54278 | 82 | 29520158 |
Septic shock | 26.99 | 14.64 | 202 | 54085 | 62358 | 29457882 |
Pneumatosis intestinalis | 26.69 | 14.64 | 31 | 54256 | 3138 | 29517102 |
Stent placement | 26.49 | 14.64 | 36 | 54251 | 4270 | 29515970 |
Skin exfoliation | 25.99 | 14.64 | 5 | 54282 | 22640 | 29497600 |
Gastrointestinal perforation | 25.93 | 14.64 | 32 | 54255 | 3451 | 29516789 |
Cardio-respiratory arrest | 25.77 | 14.64 | 33 | 54254 | 50568 | 29469672 |
Disorientation | 25.66 | 14.64 | 11 | 54276 | 29504 | 29490736 |
Mucosal inflammation | 25.57 | 14.64 | 13 | 54274 | 31582 | 29488658 |
Muscle strain | 25.57 | 14.64 | 32 | 54255 | 3501 | 29516739 |
Lethargy | 25.51 | 14.64 | 19 | 54268 | 37561 | 29482679 |
Irritability | 25.20 | 14.64 | 5 | 54282 | 22147 | 29498093 |
Heart rate decreased | 24.00 | 14.64 | 100 | 54187 | 24812 | 29495428 |
Chronic kidney disease | 23.97 | 14.64 | 19 | 54268 | 36397 | 29483843 |
Rheumatoid factor | 23.94 | 14.64 | 8 | 54279 | 74 | 29520166 |
Nephrolithiasis | 23.87 | 14.64 | 101 | 54186 | 25233 | 29495007 |
Infective spondylitis | 23.86 | 14.64 | 10 | 54277 | 181 | 29520059 |
Rheumatoid factor increased | 23.78 | 14.64 | 14 | 54273 | 538 | 29519702 |
Inappropriate schedule of product administration | 23.70 | 14.64 | 28 | 54259 | 44444 | 29475796 |
Diabetes mellitus | 23.46 | 14.64 | 139 | 54148 | 39692 | 29480548 |
Haematocrit decreased | 23.40 | 14.64 | 12 | 54275 | 29010 | 29491230 |
Ulcerative keratitis | 23.33 | 14.64 | 20 | 54267 | 1403 | 29518837 |
Urinary retention | 23.14 | 14.64 | 15 | 54272 | 31883 | 29488357 |
Abnormal behaviour | 22.85 | 14.64 | 7 | 54280 | 23120 | 29497120 |
Large intestine perforation | 22.68 | 14.64 | 45 | 54242 | 7311 | 29512929 |
Cytokine storm | 22.34 | 14.64 | 14 | 54273 | 603 | 29519637 |
Neuropathy peripheral | 22.34 | 14.64 | 62 | 54225 | 70965 | 29449275 |
Long QT syndrome | 22.30 | 14.64 | 24 | 54263 | 2234 | 29518006 |
Tubulointerstitial nephritis | 22.26 | 14.64 | 3 | 54284 | 17640 | 29502600 |
Intercepted product storage error | 22.10 | 14.64 | 9 | 54278 | 151 | 29520089 |
Thrombosis | 22.09 | 14.64 | 145 | 54142 | 42900 | 29477340 |
Lower respiratory tract congestion | 22.08 | 14.64 | 17 | 54270 | 1023 | 29519217 |
Liver disorder | 21.92 | 14.64 | 105 | 54182 | 27644 | 29492596 |
Pharyngitis | 21.87 | 14.64 | 43 | 54244 | 6940 | 29513300 |
Respiratory arrest | 21.87 | 14.64 | 10 | 54277 | 25823 | 29494417 |
Panniculitis | 21.74 | 14.64 | 18 | 54269 | 1203 | 29519037 |
Hepatic cirrhosis | 21.64 | 14.64 | 67 | 54220 | 14377 | 29505863 |
Hepatic enzyme increased | 21.24 | 14.64 | 120 | 54167 | 33679 | 29486561 |
Chills | 21.14 | 14.64 | 64 | 54223 | 71236 | 29449004 |
Infective chondritis | 21.04 | 14.64 | 5 | 54282 | 10 | 29520230 |
Toxic epidermal necrolysis | 20.85 | 14.64 | 4 | 54283 | 18149 | 29502091 |
Oral disorder | 20.79 | 14.64 | 30 | 54257 | 3763 | 29516477 |
Hepatic enzyme abnormal | 20.70 | 14.64 | 23 | 54264 | 2219 | 29518021 |
Excessive cerumen production | 20.61 | 14.64 | 10 | 54277 | 258 | 29519982 |
Bursitis | 20.56 | 14.64 | 34 | 54253 | 4798 | 29515442 |
Septic arthritis staphylococcal | 20.15 | 14.64 | 12 | 54275 | 471 | 29519769 |
Cholestasis | 19.99 | 14.64 | 9 | 54278 | 23453 | 29496787 |
Joint effusion | 19.94 | 14.64 | 31 | 54256 | 4153 | 29516087 |
Intestinal perforation | 19.76 | 14.64 | 45 | 54242 | 8041 | 29512199 |
Hypomagnesaemia | 19.75 | 14.64 | 4 | 54283 | 17464 | 29502776 |
Treatment noncompliance | 19.56 | 14.64 | 10 | 54277 | 24217 | 29496023 |
Liver function test | 19.41 | 14.64 | 6 | 54281 | 42 | 29520198 |
Body temperature decreased | 19.38 | 14.64 | 53 | 54234 | 10611 | 29509629 |
COVID-19 pneumonia | 19.00 | 14.64 | 49 | 54238 | 9473 | 29510767 |
Blood cholesterol abnormal | 18.99 | 14.64 | 18 | 54269 | 1440 | 29518800 |
Ankle operation | 18.85 | 14.64 | 9 | 54278 | 224 | 29520016 |
Alveolar proteinosis | 18.76 | 14.64 | 10 | 54277 | 316 | 29519924 |
Therapy partial responder | 18.75 | 14.64 | 34 | 54253 | 5165 | 29515075 |
Red blood cell sedimentation rate | 18.64 | 14.64 | 12 | 54275 | 542 | 29519698 |
Disturbance in attention | 18.60 | 14.64 | 8 | 54279 | 21416 | 29498824 |
Drug withdrawal syndrome | 18.58 | 14.64 | 5 | 54282 | 17979 | 29502261 |
White blood cell count increased | 18.55 | 14.64 | 25 | 54262 | 37491 | 29482749 |
Paraesthesia | 18.46 | 14.64 | 45 | 54242 | 53800 | 29466440 |
Diverticular perforation | 18.44 | 14.64 | 25 | 54262 | 2959 | 29517281 |
Jaundice | 18.39 | 14.64 | 16 | 54271 | 29280 | 29490960 |
Intentional product misuse | 18.28 | 14.64 | 22 | 54265 | 34639 | 29485601 |
Osteonecrosis of jaw | 18.21 | 14.64 | 4 | 54283 | 16506 | 29503734 |
Nausea | 18.12 | 14.64 | 399 | 53888 | 288856 | 29231384 |
Suture rupture | 18.07 | 14.64 | 10 | 54277 | 341 | 29519899 |
Oedema | 18.04 | 14.64 | 29 | 54258 | 40454 | 29479786 |
Circulatory collapse | 17.83 | 14.64 | 6 | 54281 | 18667 | 29501573 |
Weight increased | 17.76 | 14.64 | 217 | 54070 | 76450 | 29443790 |
Visual impairment | 17.73 | 14.64 | 17 | 54270 | 29691 | 29490549 |
Pulmonary hypertension | 17.73 | 14.64 | 6 | 54281 | 18602 | 29501638 |
Metabolic acidosis | 17.72 | 14.64 | 26 | 54261 | 37636 | 29482604 |
Neurological examination abnormal | 17.62 | 14.64 | 9 | 54278 | 260 | 29519980 |
Respiratory tract infection bacterial | 17.53 | 14.64 | 12 | 54275 | 601 | 29519639 |
Neutrophil count increased | 17.47 | 14.64 | 3 | 54284 | 14739 | 29505501 |
Myocardial ischaemia | 17.45 | 14.64 | 4 | 54283 | 16024 | 29504216 |
Dyspnoea exertional | 17.36 | 14.64 | 25 | 54262 | 36465 | 29483775 |
Nasal crusting | 17.30 | 14.64 | 10 | 54277 | 371 | 29519869 |
Inflammation | 17.23 | 14.64 | 85 | 54202 | 22643 | 29497597 |
Squamous cell carcinoma of lung | 17.23 | 14.64 | 18 | 54269 | 1619 | 29518621 |
Condition aggravated | 17.22 | 14.64 | 370 | 53917 | 145925 | 29374315 |
Oesophageal rupture | 17.16 | 14.64 | 10 | 54277 | 377 | 29519863 |
JC virus CSF test positive | 17.16 | 14.64 | 7 | 54280 | 118 | 29520122 |
Therapy non-responder | 17.01 | 14.64 | 106 | 54181 | 30805 | 29489435 |
Joint destruction | 16.90 | 14.64 | 9 | 54278 | 284 | 29519956 |
Delirium | 16.84 | 14.64 | 29 | 54258 | 39368 | 29480872 |
Haemorrhage | 16.80 | 14.64 | 36 | 54251 | 45036 | 29475204 |
Blood pressure increased | 16.71 | 14.64 | 208 | 54079 | 73595 | 29446645 |
Injection site pain | 16.68 | 14.64 | 21 | 54266 | 32425 | 29487815 |
Human herpesvirus 6 encephalitis | 16.65 | 14.64 | 8 | 54279 | 202 | 29520038 |
Chest pain | 16.50 | 14.64 | 129 | 54158 | 111844 | 29408396 |
Gait disturbance | 16.38 | 14.64 | 74 | 54213 | 73275 | 29446965 |
Therapeutic response decreased | 16.37 | 14.64 | 89 | 54198 | 24622 | 29495618 |
Stevens-Johnson syndrome | 16.28 | 14.64 | 5 | 54282 | 16492 | 29503748 |
Enterobacter pneumonia | 16.18 | 14.64 | 5 | 54282 | 35 | 29520205 |
Gastrointestinal disorder | 16.15 | 14.64 | 99 | 54188 | 28607 | 29491633 |
Angioedema | 16.05 | 14.64 | 21 | 54266 | 31894 | 29488346 |
Solar urticaria | 15.94 | 14.64 | 4 | 54283 | 11 | 29520229 |
Anorectal agenesis | 15.91 | 14.64 | 3 | 54284 | 0 | 29520240 |
Fluid retention | 15.87 | 14.64 | 12 | 54275 | 23548 | 29496692 |
Ventricular tachycardia | 15.86 | 14.64 | 11 | 54276 | 22563 | 29497677 |
Oropharyngeal pain | 15.85 | 14.64 | 100 | 54187 | 29185 | 29491055 |
Full blood count abnormal | 15.84 | 14.64 | 4 | 54283 | 15009 | 29505231 |
Head injury | 15.65 | 14.64 | 5 | 54282 | 16076 | 29504164 |
Oral herpes | 15.54 | 14.64 | 29 | 54258 | 4503 | 29515737 |
Bradycardia foetal | 15.42 | 14.64 | 9 | 54278 | 340 | 29519900 |
Cardiac arrest | 15.38 | 14.64 | 93 | 54194 | 85498 | 29434742 |
Medication error | 15.35 | 14.64 | 10 | 54277 | 21201 | 29499039 |
Disseminated intravascular coagulation | 15.34 | 14.64 | 75 | 54212 | 19905 | 29500335 |
Post procedural infection | 15.33 | 14.64 | 28 | 54259 | 4277 | 29515963 |
Blood potassium increased | 15.28 | 14.64 | 4 | 54283 | 14647 | 29505593 |
Disease progression | 15.26 | 14.64 | 88 | 54199 | 81828 | 29438412 |
Alopecia | 15.22 | 14.64 | 8 | 54279 | 19076 | 29501164 |
Faeces discoloured | 15.21 | 14.64 | 3 | 54284 | 13348 | 29506892 |
Pollakiuria | 15.19 | 14.64 | 6 | 54281 | 16910 | 29503330 |
Herpes simplex reactivation | 15.18 | 14.64 | 5 | 54282 | 44 | 29520196 |
Rectal haemorrhage | 15.16 | 14.64 | 25 | 54262 | 34524 | 29485716 |
Product prescribing error | 15.15 | 14.64 | 7 | 54280 | 17969 | 29502271 |
Aortoenteric fistula | 14.99 | 14.64 | 6 | 54281 | 96 | 29520144 |
Clostridium difficile colitis | 14.99 | 14.64 | 3 | 54284 | 13209 | 29507031 |
Listeria encephalitis | 14.98 | 14.64 | 5 | 54282 | 46 | 29520194 |
Vertigo | 14.90 | 14.64 | 11 | 54276 | 21850 | 29498390 |
Disseminated strongyloidiasis | 14.88 | 14.64 | 6 | 54281 | 98 | 29520142 |
Hyperglycaemia | 14.87 | 14.64 | 25 | 54262 | 34262 | 29485978 |
Scalloped tongue | 14.80 | 14.64 | 4 | 54283 | 16 | 29520224 |
Dry mouth | 14.80 | 14.64 | 11 | 54276 | 21773 | 29498467 |
Blood pressure fluctuation | 14.80 | 14.64 | 74 | 54213 | 19820 | 29500420 |
Dysgeusia | 14.70 | 14.64 | 12 | 54275 | 22662 | 29497578 |
Granuloma skin | 14.66 | 14.64 | 11 | 54276 | 637 | 29519603 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 4939.04 | 13.70 | 10731 | 256214 | 829516 | 63402271 |
Joint swelling | 3533.03 | 13.70 | 4396 | 262549 | 210986 | 64020801 |
Synovitis | 3416.58 | 13.70 | 3012 | 263933 | 96078 | 64135709 |
Contraindicated product administered | 3290.33 | 13.70 | 3060 | 263885 | 104769 | 64127018 |
Drug intolerance | 3271.04 | 13.70 | 3954 | 262991 | 184038 | 64047749 |
Treatment failure | 2537.62 | 13.70 | 2758 | 264187 | 114058 | 64117729 |
Arthropathy | 2230.23 | 13.70 | 2623 | 264322 | 118344 | 64113443 |
Therapeutic product effect decreased | 1942.18 | 13.70 | 2389 | 264556 | 112962 | 64118825 |
Arthralgia | 1679.55 | 13.70 | 4805 | 262140 | 437455 | 63794332 |
Swelling | 1355.88 | 13.70 | 2400 | 264545 | 157818 | 64073969 |
Pain | 1321.67 | 13.70 | 5142 | 261803 | 548369 | 63683418 |
Hand deformity | 1247.42 | 13.70 | 1416 | 265529 | 61355 | 64170432 |
Infusion related reaction | 1246.49 | 13.70 | 2349 | 264596 | 162118 | 64069669 |
Hypersensitivity | 1243.79 | 13.70 | 2602 | 264343 | 193850 | 64037937 |
Rheumatoid factor positive | 1219.76 | 13.70 | 1071 | 265874 | 33867 | 64197920 |
C-reactive protein abnormal | 1204.19 | 13.70 | 983 | 265962 | 28064 | 64203723 |
Pemphigus | 1180.27 | 13.70 | 1354 | 265591 | 59347 | 64172440 |
Systemic lupus erythematosus | 1129.30 | 13.70 | 1496 | 265449 | 76116 | 64155671 |
Hepatic enzyme increased | 1112.40 | 13.70 | 1957 | 264988 | 127986 | 64103801 |
Toxicity to various agents | 1057.27 | 13.70 | 131 | 266814 | 363382 | 63868405 |
Anti-cyclic citrullinated peptide antibody positive | 1056.60 | 13.70 | 1160 | 265785 | 48402 | 64183385 |
Red blood cell sedimentation rate abnormal | 1010.33 | 13.70 | 702 | 266243 | 15604 | 64216183 |
Off label use | 991.17 | 13.70 | 5190 | 261755 | 627616 | 63604171 |
Glossodynia | 987.57 | 13.70 | 1277 | 265668 | 63419 | 64168368 |
Acute kidney injury | 961.44 | 13.70 | 331 | 266614 | 448909 | 63782878 |
Peripheral swelling | 954.68 | 13.70 | 2436 | 264509 | 206717 | 64025070 |
Rheumatoid arthritis | 918.04 | 13.70 | 2070 | 264875 | 162224 | 64069563 |
Abdominal discomfort | 842.64 | 13.70 | 2134 | 264811 | 180188 | 64051599 |
Musculoskeletal stiffness | 814.11 | 13.70 | 1662 | 265283 | 121544 | 64110243 |
Drug interaction | 805.60 | 13.70 | 249 | 266696 | 361834 | 63869953 |
Intentional product use issue | 799.85 | 13.70 | 1424 | 265521 | 93940 | 64137847 |
Death | 784.72 | 13.70 | 518 | 266427 | 482187 | 63749600 |
Pericarditis | 772.43 | 13.70 | 1114 | 265831 | 61402 | 64170385 |
Wound | 754.95 | 13.70 | 1228 | 265717 | 75249 | 64156538 |
Anaemia | 715.14 | 13.70 | 337 | 266608 | 378343 | 63853444 |
Drug hypersensitivity | 704.95 | 13.70 | 2375 | 264570 | 235440 | 63996347 |
Bone erosion | 680.61 | 13.70 | 483 | 266462 | 11112 | 64220675 |
Loss of personal independence in daily activities | 662.29 | 13.70 | 1124 | 265821 | 71330 | 64160457 |
Nasopharyngitis | 630.93 | 13.70 | 2014 | 264931 | 194059 | 64037728 |
Alopecia | 622.23 | 13.70 | 1797 | 265148 | 163893 | 64067894 |
Red blood cell sedimentation rate increased | 620.76 | 13.70 | 705 | 266240 | 30530 | 64201257 |
Lower respiratory tract infection | 577.62 | 13.70 | 1236 | 265709 | 93378 | 64138409 |
Rash | 559.16 | 13.70 | 3523 | 263422 | 455026 | 63776761 |
Infection | 547.98 | 13.70 | 1847 | 265098 | 183033 | 64048754 |
Febrile neutropenia | 544.00 | 13.70 | 68 | 266877 | 187589 | 64044198 |
Helicobacter infection | 533.92 | 13.70 | 724 | 266221 | 37638 | 64194149 |
Drug abuse | 524.74 | 13.70 | 4 | 266941 | 132370 | 64099417 |
Ill-defined disorder | 505.03 | 13.70 | 758 | 266187 | 43294 | 64188493 |
Duodenal ulcer perforation | 490.27 | 13.70 | 659 | 266286 | 33966 | 64197821 |
Dehydration | 485.30 | 13.70 | 147 | 266798 | 216616 | 64015171 |
Impaired healing | 485.06 | 13.70 | 886 | 266059 | 59587 | 64172200 |
Sinusitis | 482.88 | 13.70 | 1514 | 265431 | 144414 | 64087373 |
Discomfort | 471.25 | 13.70 | 1037 | 265908 | 79841 | 64151946 |
Hyponatraemia | 465.32 | 13.70 | 40 | 266905 | 148299 | 64083488 |
Sleep disorder due to general medical condition, insomnia type | 463.73 | 13.70 | 558 | 266387 | 25712 | 64206075 |
Muscle injury | 447.90 | 13.70 | 550 | 266395 | 25887 | 64205900 |
Folliculitis | 437.42 | 13.70 | 580 | 266365 | 29497 | 64202290 |
Overdose | 416.42 | 13.70 | 78 | 266867 | 159488 | 64072299 |
C-reactive protein increased | 411.09 | 13.70 | 1085 | 265860 | 93824 | 64137963 |
Irritable bowel syndrome | 397.32 | 13.70 | 621 | 266324 | 36748 | 64195039 |
Therapeutic product effect incomplete | 394.54 | 13.70 | 1129 | 265816 | 102353 | 64129434 |
Rheumatoid nodule | 394.35 | 13.70 | 364 | 266581 | 12287 | 64219500 |
Malignant neoplasm progression | 369.32 | 13.70 | 25 | 266920 | 112846 | 64118941 |
Mobility decreased | 356.24 | 13.70 | 966 | 265979 | 84874 | 64146913 |
Intentional overdose | 355.05 | 13.70 | 3 | 266942 | 89941 | 64141846 |
Arthritis | 351.64 | 13.70 | 947 | 265998 | 82867 | 64148920 |
Weight increased | 348.16 | 13.70 | 1774 | 265171 | 211574 | 64020213 |
Maternal exposure during pregnancy | 341.42 | 13.70 | 1021 | 265924 | 94863 | 64136924 |
Seizure | 334.29 | 13.70 | 136 | 266809 | 166756 | 64065031 |
Hyperkalaemia | 326.23 | 13.70 | 24 | 266921 | 101105 | 64130682 |
Diverticulitis | 322.58 | 13.70 | 576 | 266369 | 38042 | 64193745 |
Cardiac failure congestive | 315.76 | 13.70 | 76 | 266869 | 130504 | 64101283 |
Dyspnoea | 314.76 | 13.70 | 1721 | 265224 | 716953 | 63514834 |
Thrombocytopenia | 310.87 | 13.70 | 281 | 266664 | 223520 | 64008267 |
Osteoporosis | 303.15 | 13.70 | 589 | 266356 | 41491 | 64190296 |
Stomatitis | 302.55 | 13.70 | 1070 | 265875 | 108535 | 64123252 |
Cardiac arrest | 299.80 | 13.70 | 131 | 266814 | 153933 | 64077854 |
Drug eruption | 298.01 | 13.70 | 536 | 266409 | 35600 | 64196187 |
Decreased appetite | 296.08 | 13.70 | 441 | 266504 | 280848 | 63950939 |
Knee arthroplasty | 295.83 | 13.70 | 455 | 266490 | 26544 | 64205243 |
Rhabdomyolysis | 295.21 | 13.70 | 22 | 266923 | 91704 | 64140083 |
Somnolence | 287.24 | 13.70 | 252 | 266693 | 203393 | 64028394 |
Joint stiffness | 284.69 | 13.70 | 477 | 266468 | 29927 | 64201860 |
Skin ulcer | 282.70 | 13.70 | 587 | 266358 | 43387 | 64188400 |
Product dose omission issue | 278.30 | 13.70 | 238 | 266707 | 194509 | 64037278 |
Blister | 274.92 | 13.70 | 848 | 266097 | 80119 | 64151668 |
Hypoglycaemia | 266.73 | 13.70 | 30 | 266915 | 89862 | 64141925 |
Gastrointestinal haemorrhage | 266.27 | 13.70 | 107 | 266838 | 132205 | 64099582 |
Coma | 265.70 | 13.70 | 27 | 266918 | 87588 | 64144199 |
Inflammation | 265.03 | 13.70 | 729 | 266216 | 64571 | 64167216 |
Constipation | 264.95 | 13.70 | 336 | 266609 | 229001 | 64002786 |
Blood parathyroid hormone decreased | 261.31 | 13.70 | 228 | 266717 | 7138 | 64224649 |
Cardio-respiratory arrest | 258.99 | 13.70 | 47 | 266898 | 98346 | 64133441 |
Granuloma skin | 258.85 | 13.70 | 209 | 266736 | 5865 | 64225922 |
Panniculitis | 258.54 | 13.70 | 246 | 266699 | 8633 | 64223154 |
Asthenia | 257.42 | 13.70 | 909 | 266036 | 427135 | 63804652 |
Dizziness | 256.36 | 13.70 | 917 | 266028 | 429246 | 63802541 |
Coeliac disease | 256.08 | 13.70 | 226 | 266719 | 7186 | 64224601 |
Condition aggravated | 254.10 | 13.70 | 2504 | 264441 | 369922 | 63861865 |
Atrial fibrillation | 251.95 | 13.70 | 203 | 266742 | 170886 | 64060901 |
Bradycardia | 250.61 | 13.70 | 88 | 266857 | 118131 | 64113656 |
Suicide attempt | 240.49 | 13.70 | 13 | 266932 | 70994 | 64160793 |
Hypotension | 239.89 | 13.70 | 793 | 266152 | 380181 | 63851606 |
Diarrhoea | 238.55 | 13.70 | 1884 | 265061 | 720820 | 63510967 |
Hypokalaemia | 235.01 | 13.70 | 105 | 266840 | 121798 | 64109989 |
Disability assessment scale score increased | 233.53 | 13.70 | 140 | 266805 | 2390 | 64229397 |
Depressed level of consciousness | 232.25 | 13.70 | 31 | 266914 | 81405 | 64150382 |
No adverse event | 228.33 | 13.70 | 418 | 266527 | 28143 | 64203644 |
Renal failure | 228.24 | 13.70 | 249 | 266696 | 181439 | 64050348 |
Anxiety | 226.74 | 13.70 | 304 | 266641 | 202345 | 64029442 |
Syncope | 225.96 | 13.70 | 192 | 266753 | 157443 | 64074344 |
Musculoskeletal pain | 225.45 | 13.70 | 795 | 266150 | 80499 | 64151288 |
International normalised ratio increased | 221.38 | 13.70 | 32 | 266913 | 79135 | 64152652 |
Pancytopenia | 219.93 | 13.70 | 163 | 266782 | 143146 | 64088641 |
Therapeutic response decreased | 216.12 | 13.70 | 587 | 266358 | 51601 | 64180186 |
Tremor | 213.13 | 13.70 | 180 | 266765 | 148050 | 64083737 |
Gastrointestinal disorder | 211.80 | 13.70 | 833 | 266112 | 88876 | 64142911 |
Hip arthroplasty | 210.68 | 13.70 | 343 | 266602 | 21008 | 64210779 |
Blood pressure systolic increased | 210.58 | 13.70 | 562 | 266383 | 48891 | 64182896 |
Blood pressure diastolic decreased | 207.61 | 13.70 | 349 | 266596 | 21952 | 64209835 |
Vomiting | 207.50 | 13.70 | 1383 | 265562 | 549734 | 63682053 |
Blood pressure diastolic abnormal | 206.80 | 13.70 | 251 | 266694 | 11666 | 64220121 |
Cardiac failure | 206.46 | 13.70 | 148 | 266797 | 132225 | 64099562 |
Osteoarthritis | 201.79 | 13.70 | 649 | 266296 | 62687 | 64169100 |
Tachycardia | 199.14 | 13.70 | 195 | 266750 | 149384 | 64082403 |
Agitation | 197.45 | 13.70 | 60 | 266885 | 88307 | 64143480 |
Product use issue | 194.81 | 13.70 | 1183 | 265762 | 150532 | 64081255 |
Electrocardiogram QT prolonged | 194.47 | 13.70 | 45 | 266900 | 79403 | 64152384 |
Lactic acidosis | 191.29 | 13.70 | 17 | 266928 | 61393 | 64170394 |
Injection site pain | 190.83 | 13.70 | 112 | 266833 | 111296 | 64120491 |
Fibromyalgia | 189.99 | 13.70 | 442 | 266503 | 35289 | 64196498 |
Blood cholesterol increased | 189.47 | 13.70 | 545 | 266400 | 49521 | 64182266 |
Metabolic acidosis | 186.50 | 13.70 | 34 | 266911 | 70924 | 64160863 |
Blood pressure systolic abnormal | 185.02 | 13.70 | 217 | 266728 | 9725 | 64222062 |
Cerebrovascular accident | 181.26 | 13.70 | 181 | 266764 | 137402 | 64094385 |
Rheumatic fever | 179.89 | 13.70 | 207 | 266738 | 9087 | 64222700 |
Pyrexia | 178.60 | 13.70 | 1468 | 265477 | 557176 | 63674611 |
Hallucination | 176.63 | 13.70 | 42 | 266903 | 72746 | 64159041 |
Respiratory failure | 176.02 | 13.70 | 246 | 266699 | 160937 | 64070850 |
Neuropathy peripheral | 174.78 | 13.70 | 138 | 266807 | 117387 | 64114400 |
Haemoglobin decreased | 171.98 | 13.70 | 342 | 266603 | 194721 | 64037066 |
Disease progression | 171.53 | 13.70 | 200 | 266745 | 141480 | 64090307 |
Wrong technique in product usage process | 168.90 | 13.70 | 32 | 266913 | 64942 | 64166845 |
Dysarthria | 168.47 | 13.70 | 23 | 266922 | 59383 | 64172404 |
Depression | 165.36 | 13.70 | 317 | 266628 | 182974 | 64048813 |
Unresponsive to stimuli | 165.27 | 13.70 | 11 | 266934 | 50382 | 64181405 |
Drug tolerance decreased | 165.20 | 13.70 | 173 | 266772 | 6825 | 64224962 |
Mental status changes | 159.25 | 13.70 | 30 | 266915 | 61132 | 64170655 |
Ear pain | 158.56 | 13.70 | 333 | 266612 | 24803 | 64206984 |
Neutropenia | 158.16 | 13.70 | 488 | 266457 | 239136 | 63992651 |
Rheumatoid factor negative | 157.23 | 13.70 | 81 | 266864 | 1012 | 64230775 |
Dysphagia | 156.85 | 13.70 | 127 | 266818 | 106685 | 64125102 |
Hyperglycaemia | 156.42 | 13.70 | 31 | 266914 | 60937 | 64170850 |
Respiratory arrest | 156.37 | 13.70 | 18 | 266927 | 52967 | 64178820 |
Sciatica | 156.22 | 13.70 | 292 | 266653 | 19972 | 64211815 |
Joint destruction | 154.70 | 13.70 | 125 | 266820 | 3511 | 64228276 |
Foot deformity | 153.25 | 13.70 | 258 | 266687 | 16246 | 64215541 |
Abdominal pain | 153.19 | 13.70 | 718 | 266227 | 311657 | 63920130 |
Temperature regulation disorder | 152.71 | 13.70 | 132 | 266813 | 4079 | 64227708 |
Lethargy | 152.18 | 13.70 | 55 | 266890 | 72539 | 64159248 |
Vision blurred | 151.57 | 13.70 | 93 | 266852 | 90223 | 64141564 |
Apparent death | 151.34 | 13.70 | 109 | 266836 | 2567 | 64229220 |
Orthostatic hypotension | 150.96 | 13.70 | 11 | 266934 | 46727 | 64185060 |
Urticaria | 149.90 | 13.70 | 1084 | 265861 | 146233 | 64085554 |
Coronary artery disease | 148.36 | 13.70 | 34 | 266911 | 60399 | 64171388 |
Immunodeficiency | 148.31 | 13.70 | 251 | 266694 | 15873 | 64215914 |
Balance disorder | 147.11 | 13.70 | 82 | 266863 | 83844 | 64147943 |
Oral mucosal exfoliation | 146.70 | 13.70 | 84 | 266861 | 1311 | 64230476 |
Inappropriate schedule of product administration | 145.43 | 13.70 | 102 | 266843 | 92184 | 64139603 |
Haematuria | 144.56 | 13.70 | 36 | 266909 | 60435 | 64171352 |
Drug reaction with eosinophilia and systemic symptoms | 142.43 | 13.70 | 26 | 266919 | 54191 | 64177596 |
Limb deformity | 141.84 | 13.70 | 115 | 266830 | 3246 | 64228541 |
Aggression | 140.79 | 13.70 | 14 | 266931 | 46218 | 64185569 |
Plasma cell myeloma | 140.19 | 13.70 | 14 | 266931 | 46061 | 64185726 |
Skin necrosis | 139.75 | 13.70 | 229 | 266716 | 14100 | 64217687 |
Cognitive disorder | 137.22 | 13.70 | 30 | 266915 | 55057 | 64176730 |
Fall | 136.84 | 13.70 | 1087 | 265858 | 415739 | 63816048 |
Herpes zoster | 136.34 | 13.70 | 669 | 266276 | 78518 | 64153269 |
Impaired work ability | 136.14 | 13.70 | 234 | 266711 | 14985 | 64216802 |
Psoriatic arthropathy | 135.57 | 13.70 | 441 | 266504 | 42840 | 64188947 |
Blood pressure fluctuation | 135.03 | 13.70 | 497 | 266448 | 51374 | 64180413 |
Joint laxity | 134.87 | 13.70 | 96 | 266849 | 2218 | 64229569 |
Swollen joint count increased | 131.87 | 13.70 | 161 | 266784 | 7528 | 64224259 |
Blood pressure diastolic increased | 131.79 | 13.70 | 191 | 266754 | 10561 | 64221226 |
Physical disability | 131.34 | 13.70 | 94 | 266851 | 2191 | 64229596 |
Chest pain | 130.56 | 13.70 | 518 | 266427 | 235462 | 63996325 |
Intentional product misuse | 130.56 | 13.70 | 68 | 266877 | 72227 | 64159560 |
Pain in extremity | 130.17 | 13.70 | 1866 | 265079 | 301219 | 63930568 |
Bursitis | 130.16 | 13.70 | 280 | 266665 | 21205 | 64210582 |
Joint injury | 129.89 | 13.70 | 291 | 266654 | 22656 | 64209131 |
Hypomagnesaemia | 129.23 | 13.70 | 6 | 266939 | 37370 | 64194417 |
Tenosynovitis | 129.02 | 13.70 | 199 | 266746 | 11634 | 64220153 |
Nodule | 128.96 | 13.70 | 251 | 266694 | 17696 | 64214091 |
Pulmonary fibrosis | 128.64 | 13.70 | 341 | 266604 | 29537 | 64202250 |
Neoplasm progression | 128.50 | 13.70 | 11 | 266934 | 40953 | 64190834 |
Disorientation | 128.20 | 13.70 | 36 | 266909 | 55792 | 64175995 |
Disturbance in attention | 126.23 | 13.70 | 12 | 266933 | 41062 | 64190725 |
Investigation abnormal | 125.68 | 13.70 | 75 | 266870 | 1269 | 64230518 |
Oedema peripheral | 125.22 | 13.70 | 448 | 266497 | 209869 | 64021918 |
Nausea | 124.93 | 13.70 | 2398 | 264547 | 783402 | 63448385 |
Serotonin syndrome | 124.74 | 13.70 | 10 | 266935 | 39272 | 64192515 |
Blood alkaline phosphatase increased | 124.30 | 13.70 | 39 | 266906 | 56240 | 64175547 |
Ascites | 123.29 | 13.70 | 51 | 266894 | 61950 | 64169837 |
Sedation | 122.56 | 13.70 | 14 | 266931 | 41448 | 64190339 |
Heart rate decreased | 122.46 | 13.70 | 502 | 266443 | 54565 | 64177222 |
Pneumonia aspiration | 122.39 | 13.70 | 46 | 266899 | 59225 | 64172562 |
Toxic epidermal necrolysis | 122.21 | 13.70 | 8 | 266937 | 37158 | 64194629 |
Platelet count decreased | 122.00 | 13.70 | 326 | 266619 | 167385 | 64064402 |
Food allergy | 121.26 | 13.70 | 156 | 266789 | 7695 | 64224092 |
Blood creatinine increased | 120.55 | 13.70 | 237 | 266708 | 135545 | 64096242 |
Blood glucose increased | 120.24 | 13.70 | 137 | 266808 | 97936 | 64133851 |
Musculoskeletal deformity | 119.41 | 13.70 | 57 | 266888 | 597 | 64231190 |
Haematemesis | 118.28 | 13.70 | 25 | 266920 | 46974 | 64184813 |
Joint range of motion decreased | 118.23 | 13.70 | 253 | 266692 | 19090 | 64212697 |
Urinary retention | 118.17 | 13.70 | 29 | 266916 | 49172 | 64182615 |
Pleural effusion | 117.53 | 13.70 | 215 | 266730 | 126344 | 64105443 |
Mucosal inflammation | 117.33 | 13.70 | 56 | 266889 | 62528 | 64169259 |
Human antichimeric antibody positive | 116.99 | 13.70 | 73 | 266872 | 1343 | 64230444 |
Pulmonary hypertension | 114.81 | 13.70 | 20 | 266925 | 43119 | 64188668 |
Dyskinesia | 114.69 | 13.70 | 14 | 266931 | 39374 | 64192413 |
Adverse event | 114.47 | 13.70 | 392 | 266553 | 39097 | 64192690 |
Body height below normal | 114.29 | 13.70 | 79 | 266866 | 1739 | 64230048 |
Acute myocardial infarction | 113.93 | 13.70 | 74 | 266871 | 69644 | 64162143 |
Restlessness | 113.77 | 13.70 | 15 | 266930 | 39770 | 64192017 |
Loss of consciousness | 113.59 | 13.70 | 281 | 266664 | 148084 | 64083703 |
Hypophagia | 113.02 | 13.70 | 15 | 266930 | 39572 | 64192215 |
Bronchitis chronic | 112.69 | 13.70 | 108 | 266837 | 3824 | 64227963 |
Jaundice | 111.92 | 13.70 | 31 | 266914 | 48481 | 64183306 |
Generalised tonic-clonic seizure | 111.67 | 13.70 | 16 | 266929 | 39841 | 64191946 |
Skin exfoliation | 110.68 | 13.70 | 25 | 266920 | 44860 | 64186927 |
Pulmonary oedema | 110.04 | 13.70 | 98 | 266847 | 78576 | 64153211 |
Ulcer | 109.96 | 13.70 | 273 | 266672 | 22717 | 64209070 |
Contusion | 109.29 | 13.70 | 827 | 266118 | 113138 | 64118649 |
Oral herpes | 109.07 | 13.70 | 266 | 266679 | 21886 | 64209901 |
Abnormal behaviour | 108.34 | 13.70 | 8 | 266937 | 33614 | 64198173 |
Delirium | 108.32 | 13.70 | 77 | 266868 | 69117 | 64162670 |
Drug withdrawal syndrome | 108.26 | 13.70 | 5 | 266940 | 31286 | 64200501 |
Accidental overdose | 108.08 | 13.70 | 8 | 266937 | 33549 | 64198238 |
Chest discomfort | 107.13 | 13.70 | 198 | 266747 | 115908 | 64115879 |
Incorrect dose administered | 107.02 | 13.70 | 59 | 266886 | 60706 | 64171081 |
Basal cell carcinoma | 106.48 | 13.70 | 325 | 266620 | 30513 | 64201274 |
Paraesthesia | 105.17 | 13.70 | 252 | 266693 | 134270 | 64097517 |
Hypofibrinogenaemia | 104.17 | 13.70 | 74 | 266871 | 1704 | 64230083 |
Chronic obstructive pulmonary disease | 103.64 | 13.70 | 85 | 266860 | 70963 | 64160824 |
Suicidal ideation | 102.92 | 13.70 | 75 | 266870 | 66467 | 64165320 |
Bone marrow failure | 102.78 | 13.70 | 35 | 266910 | 47917 | 64183870 |
Intentional self-injury | 102.62 | 13.70 | 4 | 266941 | 29040 | 64202747 |
Emotional distress | 102.06 | 13.70 | 14 | 266931 | 36024 | 64195763 |
Deformity | 101.80 | 13.70 | 128 | 266817 | 6169 | 64225618 |
Joint arthroplasty | 101.66 | 13.70 | 77 | 266868 | 1963 | 64229824 |
Immobile | 101.62 | 13.70 | 125 | 266820 | 5890 | 64225897 |
Myalgia | 101.09 | 13.70 | 328 | 266617 | 158289 | 64073498 |
Ventricular tachycardia | 100.21 | 13.70 | 12 | 266933 | 34253 | 64197534 |
Gastric disorder | 100.15 | 13.70 | 307 | 266638 | 28890 | 64202897 |
Treatment noncompliance | 99.91 | 13.70 | 28 | 266917 | 43454 | 64188333 |
Disability | 99.62 | 13.70 | 180 | 266765 | 11992 | 64219795 |
Diabetic ketoacidosis | 99.40 | 13.70 | 6 | 266939 | 29839 | 64201948 |
Product prescribing error | 99.18 | 13.70 | 14 | 266931 | 35255 | 64196532 |
Rheumatoid lung | 98.70 | 13.70 | 82 | 266863 | 2397 | 64229390 |
Blood creatine phosphokinase increased | 98.66 | 13.70 | 60 | 266885 | 58498 | 64173289 |
Polyarthritis | 98.46 | 13.70 | 158 | 266787 | 9557 | 64222230 |
Dyspnoea exertional | 98.21 | 13.70 | 96 | 266849 | 73634 | 64158153 |
Circulatory collapse | 98.19 | 13.70 | 12 | 266933 | 33720 | 64198067 |
Tubulointerstitial nephritis | 97.78 | 13.70 | 8 | 266937 | 30901 | 64200886 |
Confusional state | 97.61 | 13.70 | 656 | 266289 | 260488 | 63971299 |
Surgical failure | 97.35 | 13.70 | 53 | 266892 | 746 | 64231041 |
Blood bilirubin increased | 95.53 | 13.70 | 60 | 266885 | 57493 | 64174294 |
Stevens-Johnson syndrome | 95.37 | 13.70 | 14 | 266931 | 34235 | 64197552 |
Melaena | 94.29 | 13.70 | 52 | 266893 | 53496 | 64178291 |
Arthritis bacterial | 94.25 | 13.70 | 138 | 266807 | 7701 | 64224086 |
Hepatitis | 93.92 | 13.70 | 406 | 266539 | 45176 | 64186611 |
Gastrooesophageal reflux disease | 92.62 | 13.70 | 125 | 266820 | 83018 | 64148769 |
Bone cyst | 92.35 | 13.70 | 75 | 266870 | 2122 | 64229665 |
Feeling abnormal | 91.72 | 13.70 | 267 | 266678 | 133335 | 64098452 |
Fine motor skill dysfunction | 91.51 | 13.70 | 105 | 266840 | 4594 | 64227193 |
Drug level increased | 90.68 | 13.70 | 16 | 266929 | 34180 | 64197607 |
Blood pressure increased | 90.03 | 13.70 | 1101 | 265844 | 171451 | 64060336 |
Chronic kidney disease | 89.94 | 13.70 | 65 | 266880 | 57854 | 64173933 |
Blood urea increased | 89.94 | 13.70 | 35 | 266910 | 44118 | 64187669 |
Hypoxia | 89.88 | 13.70 | 141 | 266804 | 88008 | 64143779 |
Red blood cell sedimentation rate | 89.79 | 13.70 | 93 | 266852 | 3621 | 64228166 |
Blood sodium decreased | 89.58 | 13.70 | 9 | 266936 | 29473 | 64202314 |
Irritability | 89.54 | 13.70 | 21 | 266924 | 36725 | 64195062 |
Liver function test increased | 89.38 | 13.70 | 307 | 266638 | 30663 | 64201124 |
Hypervolaemia | 89.19 | 13.70 | 24 | 266921 | 38261 | 64193526 |
Cholestasis | 89.06 | 13.70 | 37 | 266908 | 44835 | 64186952 |
Osteonecrosis of jaw | 89.02 | 13.70 | 27 | 266918 | 39798 | 64191989 |
Muscle spasticity | 88.37 | 13.70 | 206 | 266739 | 16463 | 64215324 |
Hospitalisation | 87.97 | 13.70 | 109 | 266836 | 75098 | 64156689 |
Sinus tachycardia | 87.70 | 13.70 | 14 | 266931 | 32174 | 64199613 |
Haemophagocytic lymphohistiocytosis | 87.29 | 13.70 | 212 | 266733 | 17397 | 64214390 |
Femur fracture | 87.10 | 13.70 | 325 | 266620 | 33810 | 64197977 |
Pneumonia | 86.74 | 13.70 | 1714 | 265231 | 557862 | 63673925 |
Ejection fraction decreased | 86.61 | 13.70 | 9 | 266936 | 28698 | 64203089 |
Angioedema | 86.46 | 13.70 | 77 | 266868 | 61744 | 64170043 |
Musculoskeletal disorder | 86.02 | 13.70 | 213 | 266732 | 17693 | 64214094 |
Psychotic disorder | 85.78 | 13.70 | 19 | 266926 | 34559 | 64197228 |
Arthrodesis | 85.70 | 13.70 | 70 | 266875 | 1997 | 64229790 |
Toothache | 85.27 | 13.70 | 209 | 266736 | 17250 | 64214537 |
Rectal haemorrhage | 85.25 | 13.70 | 78 | 266867 | 61739 | 64170048 |
Cerebral haemorrhage | 85.16 | 13.70 | 53 | 266892 | 51037 | 64180750 |
Bone density decreased | 85.08 | 13.70 | 150 | 266795 | 9802 | 64221985 |
Depressed mood | 84.38 | 13.70 | 32 | 266913 | 40980 | 64190807 |
Renal impairment | 84.09 | 13.70 | 282 | 266663 | 134735 | 64097052 |
Blood pressure decreased | 84.03 | 13.70 | 142 | 266803 | 86057 | 64145730 |
Blood potassium decreased | 84.00 | 13.70 | 31 | 266914 | 40368 | 64191419 |
Palpitations | 83.85 | 13.70 | 193 | 266752 | 104295 | 64127492 |
Hepatic failure | 83.65 | 13.70 | 64 | 266881 | 55330 | 64176457 |
Presyncope | 83.65 | 13.70 | 21 | 266924 | 35068 | 64196719 |
Accidental exposure to product | 82.91 | 13.70 | 7 | 266938 | 26357 | 64205430 |
Grip strength decreased | 81.85 | 13.70 | 162 | 266783 | 11562 | 64220225 |
Loose body in joint | 81.48 | 13.70 | 55 | 266890 | 1163 | 64230624 |
Myoclonus | 80.86 | 13.70 | 6 | 266939 | 25112 | 64206675 |
Colitis microscopic | 79.64 | 13.70 | 124 | 266821 | 7308 | 64224479 |
Chills | 79.27 | 13.70 | 296 | 266649 | 136968 | 64094819 |
Product quality issue | 78.89 | 13.70 | 14 | 266931 | 29785 | 64202002 |
Upper gastrointestinal haemorrhage | 78.50 | 13.70 | 24 | 266921 | 35196 | 64196591 |
Myocardial infarction | 78.33 | 13.70 | 386 | 266559 | 165435 | 64066352 |
Memory impairment | 78.25 | 13.70 | 147 | 266798 | 85535 | 64146252 |
Arrhythmia | 77.64 | 13.70 | 63 | 266882 | 52881 | 64178906 |
Cardiac disorder | 77.48 | 13.70 | 70 | 266875 | 55746 | 64176041 |
Dysuria | 76.76 | 13.70 | 39 | 266906 | 42018 | 64189769 |
Sepsis | 76.21 | 13.70 | 599 | 266346 | 229742 | 64002045 |
Haemorrhage | 76.17 | 13.70 | 132 | 266813 | 79219 | 64152568 |
Speech disorder | 75.69 | 13.70 | 54 | 266891 | 48387 | 64183400 |
Body temperature decreased | 75.68 | 13.70 | 258 | 266687 | 25670 | 64206117 |
Dysgeusia | 75.43 | 13.70 | 51 | 266894 | 46996 | 64184791 |
Localised infection | 75.16 | 13.70 | 285 | 266660 | 29876 | 64201911 |
Pharyngitis | 74.68 | 13.70 | 210 | 266735 | 18829 | 64212958 |
Osteoporotic fracture | 74.50 | 13.70 | 83 | 266862 | 3515 | 64228272 |
Adverse drug reaction | 73.92 | 13.70 | 378 | 266567 | 45086 | 64186701 |
Myocardial ischaemia | 73.60 | 13.70 | 6 | 266939 | 23245 | 64208542 |
Respiratory distress | 73.40 | 13.70 | 65 | 266880 | 52266 | 64179521 |
Haemorrhage intracranial | 73.33 | 13.70 | 7 | 266938 | 23877 | 64207910 |
Terminal state | 71.31 | 13.70 | 90 | 266855 | 4354 | 64227433 |
Gamma-glutamyltransferase increased | 70.79 | 13.70 | 58 | 266887 | 48452 | 64183335 |
Transient ischaemic attack | 70.69 | 13.70 | 48 | 266897 | 44134 | 64187653 |
Presbyacusis | 70.55 | 13.70 | 69 | 266876 | 2506 | 64229281 |
Haematochezia | 69.74 | 13.70 | 104 | 266841 | 66269 | 64165518 |
Withdrawal syndrome | 69.26 | 13.70 | 8 | 266937 | 23484 | 64208303 |
Fatigue | 69.20 | 13.70 | 3772 | 263173 | 744958 | 63486829 |
Visual acuity reduced | 69.20 | 13.70 | 14 | 266931 | 27127 | 64204660 |
Abdominal distension | 68.71 | 13.70 | 188 | 266757 | 95806 | 64135981 |
Limb mass | 68.32 | 13.70 | 73 | 266872 | 2948 | 64228839 |
Altered state of consciousness | 67.91 | 13.70 | 36 | 266909 | 37866 | 64193921 |
Oxygen saturation decreased | 67.69 | 13.70 | 710 | 266235 | 106466 | 64125321 |
Blood calcium decreased | 67.66 | 13.70 | 12 | 266933 | 25542 | 64206245 |
Flushing | 67.45 | 13.70 | 140 | 266805 | 78508 | 64153279 |
Glaucoma | 66.77 | 13.70 | 183 | 266762 | 16165 | 64215622 |
Pericardial effusion | 66.43 | 13.70 | 40 | 266905 | 39214 | 64192573 |
Haematocrit decreased | 66.27 | 13.70 | 77 | 266868 | 54578 | 64177209 |
Cutaneous vasculitis | 65.22 | 13.70 | 105 | 266840 | 6368 | 64225419 |
Rash macular | 65.22 | 13.70 | 10 | 266935 | 23675 | 64208112 |
Cardiomegaly | 65.21 | 13.70 | 10 | 266935 | 23674 | 64208113 |
Haemoptysis | 65.16 | 13.70 | 64 | 266881 | 48984 | 64182803 |
Full blood count abnormal | 65.03 | 13.70 | 21 | 266924 | 29736 | 64202051 |
Pulmonary embolism | 64.98 | 13.70 | 348 | 266597 | 146008 | 64085779 |
Inappropriate antidiuretic hormone secretion | 64.70 | 13.70 | 8 | 266937 | 22281 | 64209506 |
Onychomycosis | 64.70 | 13.70 | 93 | 266852 | 5103 | 64226684 |
Joint effusion | 64.44 | 13.70 | 160 | 266785 | 13313 | 64218474 |
Pollakiuria | 64.21 | 13.70 | 25 | 266920 | 31505 | 64200282 |
Cardiogenic shock | 63.93 | 13.70 | 27 | 266918 | 32400 | 64199387 |
Ataxia | 63.93 | 13.70 | 8 | 266937 | 22076 | 64209711 |
Aphasia | 63.39 | 13.70 | 46 | 266899 | 40860 | 64190927 |
Intestinal sepsis | 63.11 | 13.70 | 37 | 266908 | 605 | 64231182 |
Infusion site reaction | 63.03 | 13.70 | 59 | 266886 | 2027 | 64229760 |
X-ray abnormal | 62.77 | 13.70 | 51 | 266894 | 1444 | 64230343 |
Body temperature increased | 62.53 | 13.70 | 309 | 266636 | 36357 | 64195430 |
Electrolyte imbalance | 62.35 | 13.70 | 14 | 266931 | 25229 | 64206558 |
Respiratory depression | 62.09 | 13.70 | 11 | 266934 | 23432 | 64208355 |
Tooth disorder | 61.98 | 13.70 | 219 | 266726 | 22183 | 64209604 |
Clostridium difficile colitis | 61.67 | 13.70 | 18 | 266927 | 27205 | 64204582 |
Multiple organ dysfunction syndrome | 61.65 | 13.70 | 214 | 266731 | 101199 | 64130588 |
Retinal toxicity | 61.46 | 13.70 | 48 | 266897 | 1282 | 64230505 |
Subdural haematoma | 60.95 | 13.70 | 20 | 266925 | 28034 | 64203753 |
Mental disorder | 60.81 | 13.70 | 17 | 266928 | 26428 | 64205359 |
Type 2 diabetes mellitus | 60.38 | 13.70 | 290 | 266655 | 33730 | 64198057 |
Hemiparesis | 60.16 | 13.70 | 24 | 266921 | 29803 | 64201984 |
Nightmare | 59.82 | 13.70 | 8 | 266937 | 20985 | 64210802 |
Muscle rigidity | 59.78 | 13.70 | 3 | 266942 | 17470 | 64214317 |
Dystonia | 59.35 | 13.70 | 5 | 266940 | 18860 | 64212927 |
Device issue | 59.18 | 13.70 | 11 | 266934 | 22637 | 64209150 |
Pulmonary thrombosis | 59.09 | 13.70 | 133 | 266812 | 10385 | 64221402 |
Obstructive airways disorder | 59.02 | 13.70 | 12 | 266933 | 23173 | 64208614 |
Delusion | 58.86 | 13.70 | 4 | 266941 | 18010 | 64213777 |
Acute respiratory failure | 58.78 | 13.70 | 72 | 266873 | 49862 | 64181925 |
Pneumonia viral | 58.16 | 13.70 | 111 | 266834 | 7711 | 64224076 |
Blood iron abnormal | 58.11 | 13.70 | 44 | 266901 | 1121 | 64230666 |
Sinus bradycardia | 57.97 | 13.70 | 12 | 266933 | 22881 | 64208906 |
Product administration error | 57.82 | 13.70 | 21 | 266924 | 27622 | 64204165 |
Myelodysplastic syndrome | 57.61 | 13.70 | 21 | 266924 | 27558 | 64204229 |
Hypersomnia | 57.42 | 13.70 | 7 | 266938 | 19710 | 64212077 |
Encephalopathy | 57.22 | 13.70 | 97 | 266848 | 58722 | 64173065 |
Transplant rejection | 56.47 | 13.70 | 4 | 266941 | 17397 | 64214390 |
Small intestinal obstruction | 56.40 | 13.70 | 14 | 266931 | 23559 | 64208228 |
Joint lock | 56.39 | 13.70 | 64 | 266881 | 2767 | 64229020 |
Torsade de pointes | 56.32 | 13.70 | 4 | 266941 | 17359 | 64214428 |
Epilepsy | 55.58 | 13.70 | 35 | 266910 | 33496 | 64198291 |
Hepatic encephalopathy | 55.54 | 13.70 | 10 | 266935 | 21056 | 64210731 |
Injection site erythema | 55.02 | 13.70 | 133 | 266812 | 70667 | 64161120 |
Aspiration | 54.45 | 13.70 | 4 | 266941 | 16881 | 64214906 |
Bone pain | 53.50 | 13.70 | 71 | 266874 | 47501 | 64184286 |
Urinary tract infection | 53.16 | 13.70 | 658 | 266287 | 230938 | 64000849 |
Therapy non-responder | 52.73 | 13.70 | 459 | 266486 | 65440 | 64166347 |
Sleep disorder | 52.62 | 13.70 | 425 | 266520 | 59284 | 64172503 |
Haemodialysis | 52.44 | 13.70 | 5 | 266940 | 17072 | 64214715 |
Acute myeloid leukaemia | 52.35 | 13.70 | 24 | 266921 | 27439 | 64204348 |
Mental impairment | 52.34 | 13.70 | 4 | 266941 | 16339 | 64215448 |
Tricuspid valve incompetence | 52.16 | 13.70 | 5 | 266940 | 16998 | 64214789 |
Mania | 52.11 | 13.70 | 4 | 266941 | 16282 | 64215505 |
Ventricular fibrillation | 51.85 | 13.70 | 17 | 266928 | 23843 | 64207944 |
Pleural thickening | 51.84 | 13.70 | 60 | 266885 | 2650 | 64229137 |
Pulmonary arterial hypertension | 51.84 | 13.70 | 20 | 266925 | 25347 | 64206440 |
Atelectasis | 51.71 | 13.70 | 24 | 266921 | 27242 | 64204545 |
Gastritis | 51.71 | 13.70 | 60 | 266885 | 42558 | 64189229 |
Spinal column injury | 51.44 | 13.70 | 50 | 266895 | 1802 | 64229985 |
Blood albumin decreased | 51.43 | 13.70 | 12 | 266933 | 21061 | 64210726 |
Faeces discoloured | 51.41 | 13.70 | 21 | 266924 | 25708 | 64206079 |
Unevaluable event | 51.23 | 13.70 | 81 | 266864 | 50408 | 64181379 |
Pleural fibrosis | 51.18 | 13.70 | 73 | 266872 | 3977 | 64227810 |
Hypothermia | 51.13 | 13.70 | 10 | 266935 | 19846 | 64211941 |
Mitral valve incompetence | 50.77 | 13.70 | 21 | 266924 | 25517 | 64206270 |
Skin papilloma | 50.53 | 13.70 | 83 | 266862 | 5120 | 64226667 |
Muscular weakness | 50.50 | 13.70 | 314 | 266631 | 127024 | 64104763 |
Anuria | 50.01 | 13.70 | 9 | 266936 | 18955 | 64212832 |
White blood cell count increased | 49.74 | 13.70 | 126 | 266819 | 65888 | 64165899 |
Metastases to bone | 49.15 | 13.70 | 12 | 266933 | 20423 | 64211364 |
Diverticular perforation | 49.07 | 13.70 | 82 | 266863 | 5131 | 64226656 |
Antibody test positive | 48.94 | 13.70 | 55 | 266890 | 2352 | 64229435 |
Angina unstable | 48.93 | 13.70 | 4 | 266941 | 15463 | 64216324 |
Soft tissue disorder | 48.88 | 13.70 | 64 | 266881 | 3212 | 64228575 |
Cardiomyopathy | 48.58 | 13.70 | 22 | 266923 | 25334 | 64206453 |
Viral upper respiratory tract infection | 48.54 | 13.70 | 106 | 266839 | 8109 | 64223678 |
Demyelination | 48.39 | 13.70 | 95 | 266850 | 6739 | 64225048 |
Bone disorder | 48.24 | 13.70 | 166 | 266779 | 16593 | 64215194 |
Fear | 48.22 | 13.70 | 12 | 266933 | 20159 | 64211628 |
Urinary incontinence | 48.22 | 13.70 | 47 | 266898 | 36104 | 64195683 |
White blood cell count decreased | 47.84 | 13.70 | 420 | 266525 | 157417 | 64074370 |
Blood lactate dehydrogenase increased | 47.70 | 13.70 | 40 | 266905 | 33038 | 64198749 |
Wheezing | 47.66 | 13.70 | 172 | 266773 | 80407 | 64151380 |
Renal tubular necrosis | 47.62 | 13.70 | 16 | 266929 | 22094 | 64209693 |
Anti-cyclic citrullinated peptide antibody | 47.46 | 13.70 | 42 | 266903 | 1340 | 64230447 |
Hypocalcaemia | 47.28 | 13.70 | 62 | 266883 | 41691 | 64190096 |
Respiratory disorder | 47.17 | 13.70 | 283 | 266662 | 35828 | 64195959 |
Hallucination, auditory | 46.99 | 13.70 | 7 | 266938 | 16932 | 64214855 |
Dialysis | 46.91 | 13.70 | 7 | 266938 | 16913 | 64214874 |
Intestinal obstruction | 46.32 | 13.70 | 49 | 266896 | 36237 | 64195550 |
Pancreatitis | 46.29 | 13.70 | 112 | 266833 | 59495 | 64172292 |
Drug specific antibody | 46.28 | 13.70 | 50 | 266895 | 2045 | 64229742 |
Agranulocytosis | 46.19 | 13.70 | 54 | 266891 | 38175 | 64193612 |
Hypophosphataemia | 46.04 | 13.70 | 4 | 266941 | 14716 | 64217071 |
Poor venous access | 45.83 | 13.70 | 134 | 266811 | 12283 | 64219504 |
Pallor | 45.56 | 13.70 | 56 | 266889 | 38725 | 64193062 |
Lymphocyte count decreased | 45.51 | 13.70 | 61 | 266884 | 40638 | 64191149 |
Graft versus host disease | 45.33 | 13.70 | 3 | 266942 | 13810 | 64217977 |
Bedridden | 45.17 | 13.70 | 117 | 266828 | 9992 | 64221795 |
Colitis | 44.97 | 13.70 | 111 | 266834 | 58563 | 64173224 |
Nephropathy toxic | 44.72 | 13.70 | 9 | 266936 | 17505 | 64214282 |
Blood glucose decreased | 44.40 | 13.70 | 20 | 266925 | 23103 | 64208684 |
Oesophagitis | 44.29 | 13.70 | 17 | 266928 | 21613 | 64210174 |
Diplopia | 44.28 | 13.70 | 28 | 266917 | 26737 | 64205050 |
Lower limb fracture | 44.21 | 13.70 | 140 | 266805 | 13405 | 64218382 |
Malignant melanoma | 44.16 | 13.70 | 136 | 266809 | 12828 | 64218959 |
Injection site hypersensitivity | 44.16 | 13.70 | 44 | 266901 | 1635 | 64230152 |
Tooth infection | 44.12 | 13.70 | 147 | 266798 | 14454 | 64217333 |
Shock | 44.11 | 13.70 | 56 | 266889 | 38184 | 64193603 |
Arteriosclerosis coronary artery | 44.05 | 13.70 | 6 | 266939 | 15523 | 64216264 |
Hypercholesterolaemia | 44.01 | 13.70 | 152 | 266793 | 15221 | 64216566 |
Hyperlipidaemia | 43.92 | 13.70 | 20 | 266925 | 22956 | 64208831 |
Ileus | 43.89 | 13.70 | 20 | 266925 | 22946 | 64208841 |
Hypovolaemia | 43.89 | 13.70 | 6 | 266939 | 15480 | 64216307 |
Mass | 43.70 | 13.70 | 151 | 266794 | 15125 | 64216662 |
Tachypnoea | 43.68 | 13.70 | 28 | 266917 | 26543 | 64205244 |
Blood magnesium increased | 43.45 | 13.70 | 60 | 266885 | 3171 | 64228616 |
Juvenile idiopathic arthritis | 43.36 | 13.70 | 66 | 266879 | 3813 | 64227974 |
Acute coronary syndrome | 43.32 | 13.70 | 13 | 266932 | 19297 | 64212490 |
Drug specific antibody present | 43.18 | 13.70 | 77 | 266868 | 5077 | 64226710 |
Seronegative arthritis | 43.14 | 13.70 | 55 | 266890 | 2688 | 64229099 |
Dry skin | 43.08 | 13.70 | 92 | 266853 | 51069 | 64180718 |
Deep vein thrombosis | 42.94 | 13.70 | 257 | 266688 | 104925 | 64126862 |
Metastases to central nervous system | 42.92 | 13.70 | 4 | 266941 | 13908 | 64217879 |
Multiple fractures | 42.81 | 13.70 | 84 | 266861 | 5956 | 64225831 |
Anal incontinence | 42.80 | 13.70 | 6 | 266939 | 15190 | 64216597 |
Status epilepticus | 42.77 | 13.70 | 18 | 266927 | 21645 | 64210142 |
Systemic lupus erythematosus rash | 42.47 | 13.70 | 40 | 266905 | 1385 | 64230402 |
Glomerular filtration rate decreased | 42.44 | 13.70 | 14 | 266931 | 19558 | 64212229 |
Cytology abnormal | 42.35 | 13.70 | 23 | 266922 | 322 | 64231465 |
Atrioventricular block complete | 42.28 | 13.70 | 5 | 266940 | 14413 | 64217374 |
Myelosuppression | 42.15 | 13.70 | 23 | 266922 | 23807 | 64207980 |
Dermatitis allergic | 42.05 | 13.70 | 148 | 266797 | 14961 | 64216826 |
Coagulopathy | 41.99 | 13.70 | 42 | 266903 | 31878 | 64199909 |
Frequent bowel movements | 41.66 | 13.70 | 12 | 266933 | 18293 | 64213494 |
Drug use disorder | 41.47 | 13.70 | 83 | 266862 | 5971 | 64225816 |
Hypokinesia | 41.40 | 13.70 | 9 | 266936 | 16587 | 64215200 |
Transaminases abnormal | 40.95 | 13.70 | 30 | 266915 | 726 | 64231061 |
Acute generalised exanthematous pustulosis | 40.92 | 13.70 | 5 | 266940 | 14053 | 64217734 |
Ventricular extrasystoles | 40.81 | 13.70 | 11 | 266934 | 17518 | 64214269 |
Dry mouth | 40.53 | 13.70 | 122 | 266823 | 60296 | 64171491 |
Sinus disorder | 40.53 | 13.70 | 10 | 266935 | 16898 | 64214889 |
Muscle twitching | 40.48 | 13.70 | 14 | 266931 | 18984 | 64212803 |
Neutrophil count decreased | 40.41 | 13.70 | 173 | 266772 | 77023 | 64154764 |
Iron deficiency anaemia | 40.39 | 13.70 | 20 | 266925 | 21869 | 64209918 |
Prothrombin time prolonged | 40.38 | 13.70 | 8 | 266937 | 15733 | 64216054 |
Finger deformity | 40.30 | 13.70 | 75 | 266870 | 5111 | 64226676 |
Head injury | 40.10 | 13.70 | 46 | 266899 | 32796 | 64198991 |
Red blood cell count decreased | 39.92 | 13.70 | 88 | 266857 | 48298 | 64183489 |
Exostosis | 39.90 | 13.70 | 121 | 266824 | 11317 | 64220470 |
Toxic skin eruption | 39.75 | 13.70 | 15 | 266930 | 19269 | 64212518 |
Brain oedema | 39.50 | 13.70 | 21 | 266924 | 22054 | 64209733 |
Myopathy | 39.49 | 13.70 | 12 | 266933 | 17668 | 64214119 |
Night sweats | 39.39 | 13.70 | 270 | 266675 | 35776 | 64196011 |
Hyperhidrosis | 39.37 | 13.70 | 329 | 266616 | 124591 | 64107196 |
Device malfunction | 39.32 | 13.70 | 12 | 266933 | 17621 | 64214166 |
Immune effector cell-associated neurotoxicity syndrome | 39.19 | 13.70 | 51 | 266894 | 2544 | 64229243 |
Oropharyngeal pain | 39.17 | 13.70 | 550 | 266395 | 88317 | 64143470 |
Right ventricular failure | 39.05 | 13.70 | 20 | 266925 | 21451 | 64210336 |
Hepatitis B virus test positive | 38.97 | 13.70 | 24 | 266921 | 431 | 64231356 |
Infiltration anaesthesia | 38.94 | 13.70 | 17 | 266928 | 142 | 64231645 |
Paranoia | 38.56 | 13.70 | 10 | 266935 | 16342 | 64215445 |
Flatulence | 38.33 | 13.70 | 55 | 266890 | 35611 | 64196176 |
Interstitial lung disease | 38.04 | 13.70 | 592 | 266353 | 97140 | 64134647 |
Vasculitic rash | 37.95 | 13.70 | 44 | 266901 | 1947 | 64229840 |
Onychomadesis | 37.95 | 13.70 | 53 | 266892 | 2831 | 64228956 |
Hypercalcaemia | 37.76 | 13.70 | 241 | 266704 | 31175 | 64200612 |
Mean platelet volume decreased | 37.69 | 13.70 | 41 | 266904 | 1690 | 64230097 |
Lip swelling | 37.56 | 13.70 | 46 | 266899 | 31861 | 64199926 |
Deafness neurosensory | 37.38 | 13.70 | 82 | 266863 | 6292 | 64225495 |
Renal injury | 37.23 | 13.70 | 9 | 266936 | 15420 | 64216367 |
Acute hepatic failure | 37.14 | 13.70 | 32 | 266913 | 26080 | 64205707 |
Troponin increased | 37.12 | 13.70 | 9 | 266936 | 15390 | 64216397 |
Vascular access complication | 36.97 | 13.70 | 33 | 266912 | 1065 | 64230722 |
Leukocytosis | 36.93 | 13.70 | 62 | 266883 | 37678 | 64194109 |
Face oedema | 36.88 | 13.70 | 29 | 266916 | 24732 | 64207055 |
Second primary malignancy | 36.88 | 13.70 | 4 | 266941 | 12333 | 64219454 |
Lower respiratory tract congestion | 36.87 | 13.70 | 53 | 266892 | 2908 | 64228879 |
Supraventricular tachycardia | 36.86 | 13.70 | 16 | 266929 | 18891 | 64212896 |
Full blood count decreased | 36.84 | 13.70 | 24 | 266921 | 22558 | 64209229 |
Device dislocation | 36.65 | 13.70 | 21 | 266924 | 21157 | 64210630 |
Multiple allergies | 36.63 | 13.70 | 77 | 266868 | 5737 | 64226050 |
Pulmonary mass | 36.50 | 13.70 | 196 | 266749 | 23820 | 64207967 |
Eating disorder | 36.47 | 13.70 | 12 | 266933 | 16793 | 64214994 |
Concomitant disease aggravated | 36.47 | 13.70 | 3 | 266942 | 11539 | 64220248 |
Alanine aminotransferase abnormal | 36.37 | 13.70 | 85 | 266860 | 6803 | 64224984 |
Drug level decreased | 36.32 | 13.70 | 3 | 266942 | 11500 | 64220287 |
Vertigo | 36.21 | 13.70 | 124 | 266821 | 58887 | 64172900 |
Hepatitis cholestatic | 36.18 | 13.70 | 4 | 266941 | 12151 | 64219636 |
Feeling hot | 36.09 | 13.70 | 85 | 266860 | 45578 | 64186209 |
Haematoma | 35.83 | 13.70 | 87 | 266858 | 46163 | 64185624 |
Peripheral sensory neuropathy | 35.83 | 13.70 | 3 | 266942 | 11375 | 64220412 |
Blood magnesium decreased | 35.81 | 13.70 | 7 | 266938 | 13898 | 64217889 |
Clostridium difficile infection | 35.76 | 13.70 | 59 | 266886 | 36104 | 64195683 |
Haemolytic anaemia | 35.66 | 13.70 | 11 | 266934 | 16042 | 64215745 |
Wheelchair user | 35.60 | 13.70 | 67 | 266878 | 4605 | 64227182 |
Cyanosis | 35.53 | 13.70 | 24 | 266921 | 22131 | 64209656 |
Caesarean section | 35.43 | 13.70 | 3 | 266942 | 11271 | 64220516 |
Mood altered | 35.41 | 13.70 | 11 | 266934 | 15968 | 64215819 |
Coronary artery stenosis | 35.33 | 13.70 | 3 | 266942 | 11245 | 64220542 |
Atrial flutter | 35.32 | 13.70 | 18 | 266927 | 19362 | 64212425 |
Synovial cyst | 35.26 | 13.70 | 90 | 266855 | 7617 | 64224170 |
Left ventricular dysfunction | 35.26 | 13.70 | 13 | 266932 | 16941 | 64214846 |
Infected bite | 35.16 | 13.70 | 35 | 266910 | 1299 | 64230488 |
Injection site mass | 34.66 | 13.70 | 14 | 266931 | 17256 | 64214531 |
Progressive multifocal leukoencephalopathy | 34.65 | 13.70 | 16 | 266929 | 18216 | 64213571 |
Foot fracture | 34.58 | 13.70 | 158 | 266787 | 17999 | 64213788 |
Extremity contracture | 34.53 | 13.70 | 38 | 266907 | 1587 | 64230200 |
Mesenteritis | 34.42 | 13.70 | 17 | 266928 | 193 | 64231594 |
Haematotoxicity | 34.26 | 13.70 | 6 | 266939 | 12890 | 64218897 |
Drug tolerance | 34.24 | 13.70 | 77 | 266868 | 6008 | 64225779 |
Injection site reaction | 34.24 | 13.70 | 319 | 266626 | 46345 | 64185442 |
Activated partial thromboplastin time prolonged | 34.03 | 13.70 | 6 | 266939 | 12825 | 64218962 |
Secretion discharge | 33.99 | 13.70 | 118 | 266827 | 11846 | 64219941 |
Ageusia | 33.44 | 13.70 | 8 | 266937 | 13805 | 64217982 |
Nervousness | 33.35 | 13.70 | 44 | 266901 | 29512 | 64202275 |
Red cell distribution width decreased | 33.19 | 13.70 | 31 | 266914 | 1062 | 64230725 |
Chromaturia | 33.03 | 13.70 | 27 | 266918 | 22584 | 64209203 |
Hyperthyroidism | 32.96 | 13.70 | 17 | 266928 | 18162 | 64213625 |
Intestinal polyp | 32.93 | 13.70 | 38 | 266907 | 1673 | 64230114 |
Pulmonary haemorrhage | 32.93 | 13.70 | 7 | 266938 | 13102 | 64218685 |
Enthesopathy | 32.73 | 13.70 | 101 | 266844 | 9537 | 64222250 |
Nail disorder | 32.72 | 13.70 | 94 | 266851 | 8530 | 64223257 |
Dementia | 32.63 | 13.70 | 23 | 266922 | 20743 | 64211044 |
Escherichia infection | 32.62 | 13.70 | 11 | 266934 | 15157 | 64216630 |
Schizophrenia | 32.44 | 13.70 | 4 | 266941 | 11164 | 64220623 |
Electrocardiogram abnormal | 32.26 | 13.70 | 8 | 266937 | 13473 | 64218314 |
Pulmonary toxicity | 32.18 | 13.70 | 93 | 266852 | 8468 | 64223319 |
Glycosylated haemoglobin increased | 32.12 | 13.70 | 13 | 266932 | 16006 | 64215781 |
Failure to thrive | 32.07 | 13.70 | 3 | 266942 | 10401 | 64221386 |
Dislocation of vertebra | 31.92 | 13.70 | 51 | 266894 | 3073 | 64228714 |
Eczema | 31.77 | 13.70 | 46 | 266899 | 29674 | 64202113 |
Hemiplegia | 31.70 | 13.70 | 7 | 266938 | 12761 | 64219026 |
Maternal exposure timing unspecified | 31.60 | 13.70 | 47 | 266898 | 2660 | 64229127 |
Rash maculo-papular | 31.51 | 13.70 | 95 | 266850 | 46931 | 64184856 |
Staphylococcal infection | 31.43 | 13.70 | 106 | 266839 | 50572 | 64181215 |
Polyuria | 31.25 | 13.70 | 7 | 266938 | 12636 | 64219151 |
Thyroid disorder | 31.23 | 13.70 | 113 | 266832 | 11579 | 64220208 |
Rales | 31.13 | 13.70 | 12 | 266933 | 15217 | 64216570 |
Prosthesis user | 31.13 | 13.70 | 12 | 266933 | 70 | 64231717 |
Atrioventricular block | 31.04 | 13.70 | 6 | 266939 | 12009 | 64219778 |
Neutrophil count increased | 31.02 | 13.70 | 35 | 266910 | 25139 | 64206648 |
Angina pectoris | 30.98 | 13.70 | 90 | 266855 | 44991 | 64186796 |
Pathogen resistance | 30.89 | 13.70 | 7 | 266938 | 12536 | 64219251 |
Atrioventricular block first degree | 30.80 | 13.70 | 4 | 266941 | 10730 | 64221057 |
Urine output decreased | 30.53 | 13.70 | 15 | 266930 | 16477 | 64215310 |
Lung infiltration | 30.44 | 13.70 | 25 | 266920 | 20864 | 64210923 |
Posterior reversible encephalopathy syndrome | 30.41 | 13.70 | 30 | 266915 | 22916 | 64208871 |
Adverse reaction | 30.35 | 13.70 | 85 | 266860 | 7602 | 64224185 |
Injection site warmth | 30.31 | 13.70 | 9 | 266936 | 13453 | 64218334 |
Hypotonia | 30.27 | 13.70 | 5 | 266940 | 11207 | 64220580 |
Cyst | 30.25 | 13.70 | 114 | 266831 | 11913 | 64219874 |
Device occlusion | 30.18 | 13.70 | 3 | 266942 | 9910 | 64221877 |
Pruritus | 30.10 | 13.70 | 1581 | 265364 | 310819 | 63920968 |
Cardiac failure acute | 30.06 | 13.70 | 15 | 266930 | 16329 | 64215458 |
Metastases to liver | 29.81 | 13.70 | 33 | 266912 | 23908 | 64207879 |
Cerebral infarction | 29.65 | 13.70 | 80 | 266865 | 40964 | 64190823 |
Muscle spasms | 29.63 | 13.70 | 408 | 266537 | 140615 | 64091172 |
Faecaloma | 29.47 | 13.70 | 3 | 266942 | 9725 | 64222062 |
Dermatitis exfoliative | 29.36 | 13.70 | 4 | 266941 | 10348 | 64221439 |
Incontinence | 29.24 | 13.70 | 7 | 266938 | 12074 | 64219713 |
Malnutrition | 28.99 | 13.70 | 22 | 266923 | 19103 | 64212684 |
Intestinal perforation | 28.97 | 13.70 | 133 | 266812 | 15180 | 64216607 |
Drug resistance | 28.83 | 13.70 | 64 | 266881 | 35038 | 64196749 |
Eyelid ptosis | 28.70 | 13.70 | 3 | 266942 | 9522 | 64222265 |
Arteriosclerosis | 28.56 | 13.70 | 15 | 266930 | 15862 | 64215925 |
Hypoalbuminaemia | 28.54 | 13.70 | 19 | 266926 | 17655 | 64214132 |
Pruritus allergic | 28.44 | 13.70 | 26 | 266919 | 866 | 64230921 |
Fracture delayed union | 28.42 | 13.70 | 38 | 266907 | 1947 | 64229840 |
Vaginal haemorrhage | 28.38 | 13.70 | 23 | 266922 | 19321 | 64212466 |
Joint dislocation | 28.28 | 13.70 | 108 | 266837 | 11357 | 64220430 |
Rash papular | 28.17 | 13.70 | 18 | 266927 | 17095 | 64214692 |
Bundle branch block left | 28.17 | 13.70 | 4 | 266941 | 10030 | 64221757 |
Wrist deformity | 28.16 | 13.70 | 36 | 266909 | 1764 | 64230023 |
Thrombotic microangiopathy | 28.14 | 13.70 | 17 | 266928 | 16638 | 64215149 |
Brachiocephalic artery stenosis | 28.06 | 13.70 | 9 | 266936 | 27 | 64231760 |
Bladder transitional cell carcinoma | 27.99 | 13.70 | 41 | 266904 | 2289 | 64229498 |
Renal disorder | 27.81 | 13.70 | 66 | 266879 | 35299 | 64196488 |
Device related infection | 27.55 | 13.70 | 53 | 266892 | 30573 | 64201214 |
Hyperthermia | 27.52 | 13.70 | 15 | 266930 | 15535 | 64216252 |
Cold sweat | 27.52 | 13.70 | 17 | 266928 | 16438 | 64215349 |
Eye swelling | 27.43 | 13.70 | 31 | 266914 | 22250 | 64209537 |
Blood fibrinogen decreased | 27.42 | 13.70 | 32 | 266913 | 1426 | 64230361 |
Ligament sprain | 27.41 | 13.70 | 103 | 266842 | 10749 | 64221038 |
Smear cervix abnormal | 27.40 | 13.70 | 41 | 266904 | 2333 | 64229454 |
Injection site swelling | 27.38 | 13.70 | 84 | 266861 | 41269 | 64190518 |
Skin laceration | 27.33 | 13.70 | 184 | 266761 | 24233 | 64207554 |
Incorrect product administration duration | 27.14 | 13.70 | 4 | 266941 | 9754 | 64222033 |
Congestive cardiomyopathy | 27.08 | 13.70 | 5 | 266940 | 10339 | 64221448 |
Panic attack | 27.07 | 13.70 | 28 | 266917 | 20925 | 64210862 |
Thermal burn | 27.05 | 13.70 | 69 | 266876 | 5837 | 64225950 |
Bunion operation | 27.03 | 13.70 | 24 | 266921 | 769 | 64231018 |
Sudden death | 26.95 | 13.70 | 26 | 266919 | 20070 | 64211717 |
Eosinophilia | 26.91 | 13.70 | 75 | 266870 | 38001 | 64193786 |
Malaise | 26.87 | 13.70 | 1353 | 265592 | 394894 | 63836893 |
Tongue disorder | 26.74 | 13.70 | 110 | 266835 | 11970 | 64219817 |
Blood loss anaemia | 26.70 | 13.70 | 12 | 266933 | 13880 | 64217907 |
Retching | 26.59 | 13.70 | 15 | 266930 | 15241 | 64216546 |
Wound infection | 26.58 | 13.70 | 127 | 266818 | 14737 | 64217050 |
Therapeutic response unexpected | 26.49 | 13.70 | 19 | 266926 | 16982 | 64214805 |
Oedema | 26.37 | 13.70 | 248 | 266697 | 91687 | 64140100 |
Ischaemic stroke | 26.33 | 13.70 | 50 | 266895 | 28985 | 64202802 |
Ankle arthroplasty | 26.18 | 13.70 | 25 | 266920 | 881 | 64230906 |
Neck pain | 25.98 | 13.70 | 378 | 266567 | 61155 | 64170632 |
Gait inability | 25.95 | 13.70 | 279 | 266666 | 42089 | 64189698 |
Purpura | 25.94 | 13.70 | 20 | 266925 | 17226 | 64214561 |
Liver disorder | 25.89 | 13.70 | 336 | 266609 | 53015 | 64178772 |
Oliguria | 25.88 | 13.70 | 14 | 266931 | 14562 | 64217225 |
Injection site pruritus | 25.64 | 13.70 | 76 | 266869 | 37750 | 64194037 |
Influenza like illness | 25.58 | 13.70 | 150 | 266795 | 61552 | 64170235 |
Dermatitis bullous | 25.48 | 13.70 | 9 | 266936 | 12045 | 64219742 |
Hepatitis C | 25.48 | 13.70 | 7 | 266938 | 11008 | 64220779 |
Skin reaction | 25.42 | 13.70 | 110 | 266835 | 12242 | 64219545 |
Cholecystitis chronic | 25.39 | 13.70 | 4 | 266941 | 9283 | 64222504 |
Gastric haemorrhage | 25.36 | 13.70 | 12 | 266933 | 13469 | 64218318 |
Anger | 25.31 | 13.70 | 17 | 266928 | 15724 | 64216063 |
Gastric infection | 25.28 | 13.70 | 47 | 266898 | 3201 | 64228586 |
Personality change | 25.15 | 13.70 | 3 | 266942 | 8590 | 64223197 |
Acute pulmonary oedema | 24.72 | 13.70 | 11 | 266934 | 12798 | 64218989 |
Amylase increased | 24.68 | 13.70 | 5 | 266940 | 9680 | 64222107 |
Epigastric discomfort | 24.65 | 13.70 | 73 | 266872 | 6738 | 64225049 |
Complication associated with device | 24.64 | 13.70 | 16 | 266929 | 15064 | 64216723 |
Nystagmus | 24.58 | 13.70 | 4 | 266941 | 9064 | 64222723 |
Hepatocellular injury | 24.52 | 13.70 | 100 | 266845 | 45135 | 64186652 |
Cardiac failure chronic | 24.48 | 13.70 | 4 | 266941 | 9037 | 64222750 |
Nephropathy | 24.37 | 13.70 | 3 | 266942 | 8383 | 64223404 |
Ulcerative keratitis | 24.33 | 13.70 | 45 | 266900 | 3052 | 64228735 |
Cough | 24.24 | 13.70 | 1013 | 265932 | 301135 | 63930652 |
Torus fracture | 24.17 | 13.70 | 10 | 266935 | 72 | 64231715 |
Polyneuropathy | 24.14 | 13.70 | 28 | 266917 | 19866 | 64211921 |
Haemodynamic instability | 24.12 | 13.70 | 16 | 266929 | 14896 | 64216891 |
Skin burning sensation | 23.97 | 13.70 | 7 | 266938 | 10576 | 64221211 |
Device leakage | 23.91 | 13.70 | 3 | 266942 | 8263 | 64223524 |
Intervertebral disc compression | 23.87 | 13.70 | 25 | 266920 | 986 | 64230801 |
Metastases to lung | 23.86 | 13.70 | 17 | 266928 | 15247 | 64216540 |
Coronary artery occlusion | 23.72 | 13.70 | 14 | 266931 | 13877 | 64217910 |
Pancreatitis acute | 23.70 | 13.70 | 94 | 266851 | 42761 | 64189026 |
Neck surgery | 23.49 | 13.70 | 30 | 266915 | 1469 | 64230318 |
Spinal stenosis | 23.46 | 13.70 | 117 | 266828 | 13814 | 64217973 |
Tuberculin test positive | 23.38 | 13.70 | 44 | 266901 | 3024 | 64228763 |
Respiratory acidosis | 23.29 | 13.70 | 6 | 266939 | 9849 | 64221938 |
Squamous cell carcinoma of skin | 23.23 | 13.70 | 10 | 266935 | 11866 | 64219921 |
Proteinuria | 23.22 | 13.70 | 50 | 266895 | 27673 | 64204114 |
Splenomegaly | 23.21 | 13.70 | 24 | 266921 | 17937 | 64213850 |
Dry eye | 23.14 | 13.70 | 202 | 266743 | 28817 | 64202970 |
Electrocardiogram QRS complex prolonged | 23.09 | 13.70 | 5 | 266940 | 9239 | 64222548 |
Diabetic eye disease | 23.08 | 13.70 | 12 | 266933 | 153 | 64231634 |
Muscle atrophy | 22.95 | 13.70 | 6 | 266939 | 9752 | 64222035 |
Dizziness postural | 22.93 | 13.70 | 6 | 266939 | 9746 | 64222041 |
Tumour lysis syndrome | 22.91 | 13.70 | 28 | 266917 | 19412 | 64212375 |
Eructation | 22.90 | 13.70 | 5 | 266940 | 9186 | 64222601 |
Cytokine storm | 22.88 | 13.70 | 23 | 266922 | 864 | 64230923 |
Androgenetic alopecia | 22.88 | 13.70 | 12 | 266933 | 156 | 64231631 |
Flank pain | 22.83 | 13.70 | 20 | 266925 | 16169 | 64215618 |
Osteonecrosis | 22.75 | 13.70 | 52 | 266893 | 28177 | 64203610 |
Amyotrophic lateral sclerosis | 22.73 | 13.70 | 31 | 266914 | 1619 | 64230168 |
Orthopnoea | 22.69 | 13.70 | 5 | 266940 | 9129 | 64222658 |
Multiple sclerosis | 22.62 | 13.70 | 27 | 266918 | 18914 | 64212873 |
Odynophagia | 22.54 | 13.70 | 6 | 266939 | 9635 | 64222152 |
Pemphigoid | 22.30 | 13.70 | 13 | 266932 | 12973 | 64218814 |
Autoimmune hepatitis | 22.24 | 13.70 | 7 | 266938 | 10077 | 64221710 |
Pain of skin | 22.21 | 13.70 | 6 | 266939 | 9541 | 64222246 |
Tendonitis | 22.20 | 13.70 | 152 | 266793 | 20130 | 64211657 |
Immune reconstitution inflammatory syndrome | 22.11 | 13.70 | 12 | 266933 | 12458 | 64219329 |
Deafness | 22.11 | 13.70 | 26 | 266919 | 18333 | 64213454 |
Foot operation | 22.08 | 13.70 | 52 | 266893 | 4183 | 64227604 |
Oral candidiasis | 21.92 | 13.70 | 39 | 266906 | 23173 | 64208614 |
Refusal of treatment by patient | 21.90 | 13.70 | 4 | 266941 | 8335 | 64223452 |
Cerebral ischaemia | 21.82 | 13.70 | 7 | 266938 | 9955 | 64221832 |
Joint ankylosis | 21.81 | 13.70 | 21 | 266924 | 748 | 64231039 |
Impaired gastric emptying | 21.77 | 13.70 | 83 | 266862 | 8721 | 64223066 |
Rash pruritic | 21.68 | 13.70 | 346 | 266599 | 57058 | 64174729 |
Hyperammonaemia | 21.62 | 13.70 | 7 | 266938 | 9897 | 64221890 |
Cytomegalovirus infection | 21.60 | 13.70 | 80 | 266865 | 37119 | 64194668 |
Mean cell volume decreased | 21.59 | 13.70 | 46 | 266899 | 3460 | 64228327 |
Erythema multiforme | 21.42 | 13.70 | 20 | 266925 | 15681 | 64216106 |
Drug-induced liver injury | 21.28 | 13.70 | 113 | 266832 | 47530 | 64184257 |
Haemorrhoids | 21.19 | 13.70 | 42 | 266903 | 23959 | 64207828 |
Bundle branch block right | 21.14 | 13.70 | 8 | 266937 | 10261 | 64221526 |
Pneumonitis | 21.11 | 13.70 | 122 | 266823 | 50243 | 64181544 |
Interleukin level increased | 21.05 | 13.70 | 16 | 266929 | 410 | 64231377 |
Cachexia | 21.05 | 13.70 | 6 | 266939 | 9211 | 64222576 |
Squamous cell carcinoma | 20.96 | 13.70 | 16 | 266929 | 13853 | 64217934 |
Hyperuricaemia | 20.88 | 13.70 | 8 | 266937 | 10183 | 64221604 |
Immune thrombocytopenia | 20.78 | 13.70 | 19 | 266926 | 15047 | 64216740 |
Wrist surgery | 20.75 | 13.70 | 20 | 266925 | 713 | 64231074 |
Metabolic encephalopathy | 20.75 | 13.70 | 4 | 266941 | 8021 | 64223766 |
Abnormal loss of weight | 20.66 | 13.70 | 3 | 266942 | 7397 | 64224390 |
Post procedural haemorrhage | 20.57 | 13.70 | 13 | 266932 | 12418 | 64219369 |
Thirst | 20.50 | 13.70 | 17 | 266928 | 14120 | 64217667 |
Asphyxia | 20.46 | 13.70 | 7 | 266938 | 9559 | 64222228 |
Partial seizures | 20.31 | 13.70 | 3 | 266942 | 7304 | 64224483 |
Left ventricular hypertrophy | 20.26 | 13.70 | 7 | 266938 | 9499 | 64222288 |
Respiratory syncytial virus infection | 20.17 | 13.70 | 3 | 266942 | 7265 | 64224522 |
Protein urine present | 20.14 | 13.70 | 6 | 266939 | 8950 | 64222837 |
Electrocardiogram ST segment elevation | 20.13 | 13.70 | 3 | 266942 | 7256 | 64224531 |
Obesity | 20.13 | 13.70 | 150 | 266795 | 20412 | 64211375 |
Haemorrhagic stroke | 20.08 | 13.70 | 8 | 266937 | 9943 | 64221844 |
Paraesthesia oral | 20.04 | 13.70 | 15 | 266930 | 13116 | 64218671 |
Major depression | 19.99 | 13.70 | 4 | 266941 | 7812 | 64223975 |
Bronchospasm | 19.96 | 13.70 | 37 | 266908 | 21645 | 64210142 |
Hepatic function abnormal | 19.74 | 13.70 | 375 | 266570 | 63938 | 64167849 |
Arthritis infective | 19.68 | 13.70 | 69 | 266876 | 6961 | 64224826 |
Device difficult to use | 19.57 | 13.70 | 8 | 266937 | 9790 | 64221997 |
Bronchitis | 19.56 | 13.70 | 589 | 266356 | 108154 | 64123633 |
Metabolic disorder | 19.56 | 13.70 | 4 | 266941 | 7693 | 64224094 |
Limb discomfort | 19.55 | 13.70 | 185 | 266760 | 26990 | 64204797 |
Eye movement disorder | 19.46 | 13.70 | 3 | 266942 | 7076 | 64224711 |
Adenoiditis | 19.38 | 13.70 | 7 | 266938 | 33 | 64231754 |
Pulmonary alveolar haemorrhage | 19.37 | 13.70 | 8 | 266937 | 9730 | 64222057 |
Paralysis | 19.36 | 13.70 | 12 | 266933 | 11583 | 64220204 |
Tendon disorder | 19.35 | 13.70 | 64 | 266881 | 6268 | 64225519 |
Catatonia | 19.28 | 13.70 | 4 | 266941 | 7616 | 64224171 |
Blood uric acid increased | 19.23 | 13.70 | 5 | 266940 | 8158 | 64223629 |
Aplasia pure red cell | 19.22 | 13.70 | 3 | 266942 | 7011 | 64224776 |
Fear of injection | 19.19 | 13.70 | 61 | 266884 | 5851 | 64225936 |
Gastropleural fistula | 19.06 | 13.70 | 8 | 266937 | 60 | 64231727 |
Ankylosing spondylitis | 19.04 | 13.70 | 76 | 266869 | 8158 | 64223629 |
Vaginal haematoma | 18.93 | 13.70 | 10 | 266935 | 132 | 64231655 |
Abortion spontaneous | 18.93 | 13.70 | 48 | 266897 | 25095 | 64206692 |
Underdose | 18.91 | 13.70 | 50 | 266895 | 25779 | 64206008 |
Lipase increased | 18.89 | 13.70 | 19 | 266926 | 14383 | 64217404 |
Central nervous system lesion | 18.78 | 13.70 | 13 | 266932 | 11836 | 64219951 |
Eyelid oedema | 18.77 | 13.70 | 14 | 266931 | 12265 | 64219522 |
Post transplant lymphoproliferative disorder | 18.73 | 13.70 | 8 | 266937 | 9536 | 64222251 |
COVID-19 | 18.56 | 13.70 | 176 | 266769 | 64964 | 64166823 |
Brain injury | 18.54 | 13.70 | 9 | 266936 | 9956 | 64221831 |
Disability assessment scale score decreased | 18.54 | 13.70 | 5 | 266940 | 6 | 64231781 |
Bone swelling | 18.51 | 13.70 | 24 | 266921 | 1193 | 64230594 |
Adjustment disorder with depressed mood | 18.43 | 13.70 | 35 | 266910 | 2422 | 64229365 |
Urosepsis | 18.37 | 13.70 | 40 | 266905 | 22054 | 64209733 |
Disseminated large cell lymphoma | 18.31 | 13.70 | 8 | 266937 | 67 | 64231720 |
Ileus paralytic | 18.28 | 13.70 | 6 | 266939 | 8409 | 64223378 |
Pustular psoriasis | 18.26 | 13.70 | 48 | 266897 | 4135 | 64227652 |
Breath sounds abnormal | 18.24 | 13.70 | 13 | 266932 | 11656 | 64220131 |
Hepatocellular carcinoma | 18.24 | 13.70 | 6 | 266939 | 8397 | 64223390 |
Infected skin ulcer | 18.23 | 13.70 | 39 | 266906 | 2941 | 64228846 |
Nervous system disorder | 18.20 | 13.70 | 43 | 266902 | 23035 | 64208752 |
Infectious pleural effusion | 18.14 | 13.70 | 38 | 266907 | 2824 | 64228963 |
Bladder prolapse | 18.14 | 13.70 | 23 | 266922 | 1118 | 64230669 |
Normochromic normocytic anaemia | 18.02 | 13.70 | 3 | 266942 | 6687 | 64225100 |
Thiopurine methyltransferase decreased | 17.91 | 13.70 | 13 | 266932 | 310 | 64231477 |
Extrasystoles | 17.90 | 13.70 | 3 | 266942 | 6655 | 64225132 |
Petechiae | 17.85 | 13.70 | 31 | 266914 | 18595 | 64213192 |
Myositis | 17.85 | 13.70 | 25 | 266920 | 16352 | 64215435 |
Skin discolouration | 17.84 | 13.70 | 80 | 266865 | 35175 | 64196612 |
Nerve injury | 17.82 | 13.70 | 71 | 266874 | 7614 | 64224173 |
Localised oedema | 17.74 | 13.70 | 4 | 266941 | 7187 | 64224600 |
Mental fatigue | 17.73 | 13.70 | 15 | 266930 | 450 | 64231337 |
Cerebral haematoma | 17.71 | 13.70 | 4 | 266941 | 7181 | 64224606 |
Abscess limb | 17.71 | 13.70 | 61 | 266884 | 6100 | 64225687 |
Exercise tolerance decreased | 17.64 | 13.70 | 5 | 266940 | 7705 | 64224082 |
Gout | 17.62 | 13.70 | 39 | 266906 | 21374 | 64210413 |
Hyperreflexia | 17.58 | 13.70 | 4 | 266941 | 7144 | 64224643 |
Ventricular hypertrophy | 17.38 | 13.70 | 3 | 266942 | 6513 | 64225274 |
Injection site inflammation | 17.28 | 13.70 | 40 | 266905 | 3181 | 64228606 |
Retinitis | 17.27 | 13.70 | 31 | 266914 | 2054 | 64229733 |
Nephrotic syndrome | 17.26 | 13.70 | 9 | 266936 | 9558 | 64222229 |
Hepatomegaly | 17.20 | 13.70 | 27 | 266918 | 16855 | 64214932 |
Generalised oedema | 17.14 | 13.70 | 38 | 266907 | 20815 | 64210972 |
Peritonitis bacterial | 17.09 | 13.70 | 8 | 266937 | 9035 | 64222752 |
Infected varicose vein | 17.01 | 13.70 | 6 | 266939 | 26 | 64231761 |
Ammonia increased | 16.97 | 13.70 | 4 | 266941 | 6973 | 64224814 |
Dermatitis contact | 16.95 | 13.70 | 8 | 266937 | 8992 | 64222795 |
Reactive gastropathy | 16.95 | 13.70 | 14 | 266931 | 406 | 64231381 |
Allergic oedema | 16.86 | 13.70 | 18 | 266927 | 726 | 64231061 |
Diaphragmatic rupture | 16.83 | 13.70 | 11 | 266934 | 220 | 64231567 |
Injection site urticaria | 16.77 | 13.70 | 13 | 266932 | 11168 | 64220619 |
Aphthous ulcer | 16.76 | 13.70 | 101 | 266844 | 12805 | 64218982 |
Live birth | 16.73 | 13.70 | 91 | 266854 | 11113 | 64220674 |
Cystitis haemorrhagic | 16.71 | 13.70 | 6 | 266939 | 7950 | 64223837 |
Hiatus hernia | 16.71 | 13.70 | 36 | 266909 | 19921 | 64211866 |
Hypoaesthesia oral | 16.70 | 13.70 | 14 | 266931 | 11566 | 64220221 |
Mean cell haemoglobin decreased | 16.69 | 13.70 | 46 | 266899 | 4076 | 64227711 |
Abscess rupture | 16.68 | 13.70 | 12 | 266933 | 282 | 64231505 |
Periorbital oedema | 16.61 | 13.70 | 5 | 266940 | 7409 | 64224378 |
Bronchitis viral | 16.59 | 13.70 | 21 | 266924 | 1019 | 64230768 |
Retinal haemorrhage | 16.56 | 13.70 | 5 | 266940 | 7393 | 64224394 |
Lower gastrointestinal haemorrhage | 16.51 | 13.70 | 20 | 266925 | 13919 | 64217868 |
Feeling jittery | 16.42 | 13.70 | 12 | 266933 | 10623 | 64221164 |
Bacille Calmette-Guerin scar reactivation | 16.32 | 13.70 | 6 | 266939 | 30 | 64231757 |
Dysstasia | 16.21 | 13.70 | 46 | 266899 | 23169 | 64208618 |
Pulmonary congestion | 16.17 | 13.70 | 48 | 266897 | 23832 | 64207955 |
Tooth abscess | 15.96 | 13.70 | 105 | 266840 | 13721 | 64218066 |
Product storage error | 15.89 | 13.70 | 19 | 266926 | 13299 | 64218488 |
Neurotoxicity | 15.87 | 13.70 | 59 | 266886 | 27345 | 64204442 |
Acidosis | 15.83 | 13.70 | 31 | 266914 | 17764 | 64214023 |
Multiple system atrophy | 15.82 | 13.70 | 13 | 266932 | 374 | 64231413 |
Decreased activity | 15.81 | 13.70 | 5 | 266940 | 7175 | 64224612 |
Human anti-human antibody test | 15.79 | 13.70 | 13 | 266932 | 375 | 64231412 |
Cardiac tamponade | 15.77 | 13.70 | 7 | 266938 | 8157 | 64223630 |
Rheumatoid factor increased | 15.70 | 13.70 | 24 | 266921 | 1392 | 64230395 |
Blood thyroid stimulating hormone increased | 15.70 | 13.70 | 6 | 266939 | 7648 | 64224139 |
Pleurisy | 15.62 | 13.70 | 78 | 266867 | 9213 | 64222574 |
Mouth ulceration | 15.60 | 13.70 | 204 | 266741 | 32240 | 64199547 |
Gynaecomastia | 15.55 | 13.70 | 3 | 266942 | 6013 | 64225774 |
Swelling face | 15.55 | 13.70 | 163 | 266782 | 59003 | 64172784 |
Thinking abnormal | 15.44 | 13.70 | 15 | 266930 | 11541 | 64220246 |
Thrombotic thrombocytopenic purpura | 15.44 | 13.70 | 3 | 266942 | 5981 | 64225806 |
Taste disorder | 15.42 | 13.70 | 10 | 266935 | 9423 | 64222364 |
Laryngitis | 15.41 | 13.70 | 88 | 266857 | 10943 | 64220844 |
Eye haemorrhage | 15.37 | 13.70 | 72 | 266873 | 8288 | 64223499 |
Oesophageal candidiasis | 15.29 | 13.70 | 7 | 266938 | 8010 | 64223777 |
Osteosclerosis | 15.22 | 13.70 | 40 | 266905 | 3446 | 64228341 |
Shock haemorrhagic | 15.15 | 13.70 | 29 | 266916 | 16762 | 64215025 |
Anticipatory anxiety | 15.09 | 13.70 | 11 | 266934 | 264 | 64231523 |
Glucose tolerance impaired | 15.08 | 13.70 | 4 | 266941 | 6439 | 64225348 |
Aplasia | 15.03 | 13.70 | 5 | 266940 | 6948 | 64224839 |
Blood triglycerides increased | 15.00 | 13.70 | 35 | 266910 | 18831 | 64212956 |
Abnormal faeces | 14.98 | 13.70 | 3 | 266942 | 5856 | 64225931 |
Intervertebral disc space narrowing | 14.95 | 13.70 | 23 | 266922 | 1341 | 64230446 |
Eosinophil count increased | 14.93 | 13.70 | 22 | 266923 | 14090 | 64217697 |
Hepatic steatosis | 14.93 | 13.70 | 195 | 266750 | 30812 | 64200975 |
BK virus infection | 14.89 | 13.70 | 6 | 266939 | 7406 | 64224381 |
Hyperbilirubinaemia | 14.81 | 13.70 | 42 | 266903 | 21163 | 64210624 |
Duodenal ulcer | 14.79 | 13.70 | 23 | 266922 | 14412 | 64217375 |
Effusion | 14.72 | 13.70 | 28 | 266917 | 1940 | 64229847 |
Acute graft versus host disease in skin | 14.69 | 13.70 | 5 | 266940 | 6850 | 64224937 |
Disseminated mucormycosis | 14.65 | 13.70 | 14 | 266931 | 494 | 64231293 |
Urine analysis abnormal | 14.61 | 13.70 | 3 | 266942 | 5753 | 64226034 |
Growth failure | 14.47 | 13.70 | 10 | 266935 | 220 | 64231567 |
Cerebral atrophy | 14.47 | 13.70 | 6 | 266939 | 7279 | 64224508 |
Blood phosphorus decreased | 14.42 | 13.70 | 3 | 266942 | 5702 | 64226085 |
Post procedural complication | 14.40 | 13.70 | 43 | 266902 | 21310 | 64210477 |
Hepatic enzyme abnormal | 14.40 | 13.70 | 55 | 266890 | 5784 | 64226003 |
Migraine | 14.38 | 13.70 | 178 | 266767 | 62499 | 64169288 |
Premature delivery | 14.37 | 13.70 | 35 | 266910 | 18554 | 64213233 |
Red blood cell sedimentation rate decreased | 14.35 | 13.70 | 10 | 266935 | 223 | 64231564 |
Oesophageal ulcer | 14.26 | 13.70 | 4 | 266941 | 6206 | 64225581 |
Stress at work | 14.26 | 13.70 | 19 | 266926 | 970 | 64230817 |
Rheumatoid vasculitis | 14.25 | 13.70 | 13 | 266932 | 432 | 64231355 |
Hypercapnia | 14.24 | 13.70 | 7 | 266938 | 7687 | 64224100 |
Rheumatoid factor | 14.08 | 13.70 | 8 | 266937 | 123 | 64231664 |
Rhinovirus infection | 14.07 | 13.70 | 4 | 266941 | 6152 | 64225635 |
Myocarditis | 14.05 | 13.70 | 31 | 266914 | 17012 | 64214775 |
Hypoxic-ischaemic encephalopathy | 14.03 | 13.70 | 6 | 266939 | 7146 | 64224641 |
Premature labour | 14.00 | 13.70 | 7 | 266938 | 7613 | 64224174 |
Injection site induration | 13.89 | 13.70 | 10 | 266935 | 8922 | 64222865 |
Shoulder arthroplasty | 13.84 | 13.70 | 33 | 266912 | 2676 | 64229111 |
Blood glucose abnormal | 13.84 | 13.70 | 10 | 266935 | 8903 | 64222884 |
Sensory loss | 13.82 | 13.70 | 13 | 266932 | 10156 | 64221631 |
Blood urine present | 13.81 | 13.70 | 35 | 266910 | 18305 | 64213482 |
Affective disorder | 13.76 | 13.70 | 5 | 266940 | 6575 | 64225212 |
Endodontic procedure | 13.75 | 13.70 | 30 | 266915 | 2293 | 64229494 |
Excessive cerumen production | 13.73 | 13.70 | 14 | 266931 | 535 | 64231252 |
Hypocomplementaemia | 13.73 | 13.70 | 9 | 266936 | 181 | 64231606 |
None
Source | Code | Description |
---|---|---|
ATC | L04AC07 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Interleukin inhibitors |
FDA MoA | N0000190478 | Interleukin 6 Receptor Antagonists |
FDA EPC | N0000190480 | Interleukin-6 Receptor Antagonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Castleman's disease | indication | 207036003 | DOID:0111157 |
Still's disease | indication | 410794002 | |
Juvenile rheumatoid arthritis | indication | 410795001 | |
Giant cell arteritis | indication | 414341000 | DOID:13375 |
Cytokine release syndrome induced by tumor-specific T-cell infusion therapy | indication | 710027002 | |
Pneumonia caused by Severe acute respiratory syndrome coronavirus 2 | indication |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Interleukin-6 receptor | Membrane receptor | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
ID | Source |
---|---|
D02596 | KEGG_DRUG |
4029705 | VUID |
N0000180629 | NUI |
4029705 | VANDF |
CHEMBL1237022 | ChEMBL_ID |
C502936 | MESH_SUPPLEMENTAL_RECORD_UI |
6881 | IUPHAR_LIGAND_ID |
8394 | INN_ID |
DB06273 | DRUGBANK_ID |
I031V2H011 | UNII |
10150081 | PUBCHEM_CID |
612865 | RXNORM |
169600 | MMSL |
26778 | MMSL |
d07496 | MMSL |
444648007 | SNOMEDCT_US |
444649004 | SNOMEDCT_US |
C1609165 | UMLSCUI |
013198 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-135 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-135 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-136 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-136 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-137 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
ACTEMRA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-137 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | BLA | 33 sections |
Actemra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-138 | INJECTION, SOLUTION | 180 mg | SUBCUTANEOUS | BLA | 33 sections |
Actemra | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-138 | INJECTION, SOLUTION | 180 mg | SUBCUTANEOUS | BLA | 33 sections |
Actemra ACTPen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-143 | INJECTION, SOLUTION | 180 mg | SUBCUTANEOUS | BLA | 33 sections |
Actemra ACTPen | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-143 | INJECTION, SOLUTION | 180 mg | SUBCUTANEOUS | BLA | 33 sections |