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corticotropin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
corticosteroids, except prednisolone derivatives	4931	9002-60-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: corticotropin ACTH corticotrophin adrenocorticotrophic hormone acthar gel cortrophin corticotropin zinc hydroxide corticotropin-zinc hydroxide cortrophin-zinc	A hormone made in the pituitary gland. ACTH acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More ACTH is made during times of stress. Molecular weight: 4541.14 Formula: C207H308N56O58S CLOGP: LIPINSKI: None HAC: 114 HDO: 63 TPSA: 1836.25 ALOGS: ROTB: 145

Molecule

Description

Molfile Inchi Smiles

Synonyms:

corticotropin
ACTH
corticotrophin
adrenocorticotrophic hormone
acthar gel
cortrophin
corticotropin zinc hydroxide
corticotropin-zinc hydroxide
cortrophin-zinc

A hormone made in the pituitary gland. ACTH acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More ACTH is made during times of stress.

Molecular weight: 4541.14
Formula: C207H308N56O58S
CLOGP:
LIPINSKI: None
HAC: 114
HDO: 63
TPSA: 1836.25
ALOGS:
ROTB: 145

Drug dosage:

Dose	Unit	Route
25	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 3, 1950	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple sclerosis relapse	164.63	19.77	88	6888	48390	63433656
Injection site bruising	136.44	19.77	74	6902	41836	63440210
Product dose omission issue	134.15	19.77	146	6830	234167	63247879
Blood glucose increased	75.45	19.77	67	6909	83689	63398357
Swelling face	65.72	19.77	55	6921	63420	63418626
Therapy cessation	65.18	19.77	41	6935	30416	63451630
Fluid retention	52.24	19.77	47	6929	59639	63422407
Weight increased	50.27	19.77	97	6879	260695	63221351
Epidural lipomatosis	43.35	19.77	8	6968	111	63481935
Skin hyperpigmentation	42.44	19.77	18	6958	5903	63476143

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Infantile spasms	68.52	26.77	12	2431	198	34954290
Fluid retention	60.79	26.77	32	2411	26855	34927633
Product dose omission issue	48.12	26.77	50	2393	119661	34834827
Hospitalisation	47.50	26.77	36	2407	56866	34897622
Blood glucose increased	42.45	26.77	36	2407	66682	34887806
Irritability	41.01	26.77	24	2419	24666	34929822
Weight increased	39.41	26.77	40	2403	92993	34861495
Drug ineffective	38.06	26.77	92	2351	456659	34497829
Insomnia	37.47	26.77	41	2402	103866	34850622
Multiple sclerosis relapse	36.55	26.77	18	2425	13115	34941373

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Injection site bruising	118.42	22.62	60	6264	40942	79697122
Product dose omission issue	106.88	22.62	114	6210	247423	79490641
Multiple sclerosis relapse	105.70	22.62	58	6266	46475	79691589
Blood glucose increased	80.05	22.62	69	6255	114906	79623158
Therapy cessation	72.24	22.62	42	6282	37520	79700544
Fluid retention	65.73	22.62	50	6274	69759	79668305
Insomnia	58.70	22.62	84	6240	245086	79492978
Cushingoid	56.30	22.62	23	6301	9529	79728535
Weight increased	53.58	22.62	86	6238	277300	79460764
Irritability	51.39	22.62	35	6289	41109	79696955

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	H01AA01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES ACTH
CHEBI has role	CHEBI:33295	diagnostic aid
FDA CS	M0000499	Adrenocorticotropic Hormone
FDA EPC	N0000175941	Adrenocorticotropic Hormone

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
West syndrome	indication	28055006
Stevens-Johnson syndrome	indication	73442001	DOID:0050426
Exacerbation of multiple sclerosis	indication	192929006

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🐶 Veterinary Drug Use

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Species	Use	Relation
Cats	Stimulation of the adrenal cortex where there is a general deficiency of ACTH	Indication
Cattle	Stimulation of the adrenal cortex where there is a general deficiency of ACTH	Indication
Cattle	Primary bovine ketosis	Indication
Dogs	Diagnostic aid to test for adrenal dysfunction	Indication
Dogs	Stimulation of the adrenal cortex where there is a general deficiency of ACTH	Indication

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🐶 Veterinary products

Product	Applicant	Ingredients
ACTH Gel	Bimeda Animal Health Limited	1
Adrenomone	Dechra, Ltd.	1

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.15	acidic
pKa10	12.25	acidic
pKa11	12.36	acidic
pKa12	12.63	acidic
pKa13	12.69	acidic
pKa14	12.93	acidic
pKa15	13.11	acidic
pKa16	13.11	acidic
pKa17	13.22	acidic
pKa18	13.41	acidic

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Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Adrenocorticotropic hormone receptor	GPCR	Q01718	ACTHR_HUMAN	AGONIST			UNKNOWN	IUPHAR
Melanocortin receptor 4	GPCR	P32245	MC4R_HUMAN	AGONIST	Ki	6.16	IUPHAR
Melanocortin receptor 3	GPCR	P41968	MC3R_HUMAN	AGONIST	Ki	7.06	IUPHAR
Melanocyte-stimulating hormone receptor	GPCR	Q01726	MSHR_HUMAN	AGONIST	Ki	8.60	IUPHAR
Adrenocorticotropic hormone receptor	GPCR		ACTHR_MOUSE	AGONIST	Kd	9.80	IUPHAR

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External reference:

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ID	Source
002113	NDDF
002114	NDDF
12427-33-7	SECONDARY_CAS_RN
126187000	SNOMEDCT_US
1366	INN_ID
16132265	PUBCHEM_CID
2492	MMSL
2584471	RXNORM
326050	MMSL
3633	IUPHAR_LIGAND_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
1 Detoxification	HUMAN OTC DRUG LABEL	81	55146-011	LIQUID	30 [hp_C]	ORAL	unapproved homeopathic	9 sections
Acthar	HUMAN PRESCRIPTION DRUG LABEL	1	63004-8710	INJECTION	80 [USPU]	INTRAMUSCULAR	NDA	27 sections
Acthar	HUMAN PRESCRIPTION DRUG LABEL	1	63004-8710	INJECTION	80 [USPU]	INTRAMUSCULAR	NDA	27 sections
Acthar	HUMAN PRESCRIPTION DRUG LABEL	1	63004-8710	INJECTION	80 [USPU]	INTRAMUSCULAR	NDA	27 sections
Purified Cortrophin Gel	HUMAN PRESCRIPTION DRUG LABEL	1	62559-860	INJECTION	80 [USPU]	INTRAMUSCULAR	NDA	15 sections
Purified Cortrophin Gel	HUMAN PRESCRIPTION DRUG LABEL	1	62559-860	INJECTION	80 [USPU]	INTRAMUSCULAR	NDA	15 sections
Purified Cortrophin Gel	HUMAN PRESCRIPTION DRUG LABEL	1	62559-860	INJECTION	80 [USPU]	INTRAMUSCULAR	NDA	15 sections

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