thyrotropin alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4930 194100-83-9

Description:

MoleculeDescription

Synonyms:

  • thyrotropin alfa
  • thyrogen
  • thyroid stimulating hormone
  • thyrotropin
A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.90 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 9, 2000 EMA SANOFI B.V.
May 26, 1953 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nausea 57.75 35.30 62 757 854409 62633794
Blood thyroid stimulating hormone decreased 51.89 35.30 12 807 4578 63483625
Product administered at inappropriate site 45.16 35.30 10 809 3139 63485064

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood thyroid stimulating hormone decreased 52.06 33.64 12 802 5704 79737870
Product administered at inappropriate site 45.20 33.64 10 804 3955 79739619
Nausea 40.75 33.64 49 765 957147 78786427

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H01AB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
Thyrotropin
ATC V04CJ01 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for thyreoidea function
FDA CS M0021496 Thyrotropin
FDA EPC N0000175949 Thyroid Stimulating Hormone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Serum thyroglobulin level indication 391378005




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs No Use Class Stated Or Implied Indication

🐶 Veterinary products

ProductApplicantIngredients
Dermathycin Injectable Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thyrotropin receptor GPCR AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D06120 KEGG_DRUG
4021142 VUID
N0000180238 NUI
4021142 VANDF
CHEMBL1201533 ChEMBL_ID
9002-71-5 SECONDARY_CAS_RN
DB00024 DRUGBANK_ID
DB15263 DRUGBANK_ID
10579 RXNORM
14103 MMSL
7866 MMSL
d04377 MMSL
002112 NDDF
007686 NDDF
326013007 SNOMEDCT_US
407733000 SNOMEDCT_US
412520006 SNOMEDCT_US
65428006 SNOMEDCT_US
C2587204 UMLSCUI
D057073 MESH_DESCRIPTOR_UI
D013972 MESH_DESCRIPTOR_UI
CHEMBL1201532 ChEMBL_ID
7668 INN_ID
32281 PUBCHEM_CID
679 INN_ID
AVX3D5A4LM UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Thyrogen HUMAN PRESCRIPTION DRUG LABEL 1 58468-0030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 0.90 mg INTRAMUSCULAR BLA 28 sections
Thyrogen HUMAN PRESCRIPTION DRUG LABEL 1 58468-0030 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 0.90 mg INTRAMUSCULAR BLA 28 sections