follitropin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
atropine derivatives	4928	146479-72-3

Description:

Molecule	Description
Synonyms: follitropin delta follitropin alfa follitropin beta follitropin alfa/beta follicle-stimulating hormone urofollitropin follitropin human follicle stimulating hormone FSH	A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine. Molecular weight: 22668.79 Formula: C975H1493N267O305S26 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 5077.47 ALOGS: ROTB: None

Molecule

Description

Synonyms:

follitropin delta
follitropin alfa
follitropin beta
follitropin alfa/beta
follicle-stimulating hormone
urofollitropin
follitropin
human follicle stimulating hormone
FSH

A protein extract of human menopausal urine in which LUTEINIZING HORMONE has been partially or completely removed. Urofollitropin represents FOLLICLE STIMULATING HORMONE from the urine.

Molecular weight: 22668.79
Formula: C975H1493N267O305S26
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 5077.47
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
75	U	P
75	U	P
75	U	P
12	mcg	P

ADMET properties:

None

Approvals:

Date	Agency	Company
May 2, 1996	EMA	N.V. Organon
Sept. 18, 1986	FDA	SERONO
Jan. 23, 2006	PMDA	SERONO JAPAN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ovarian hyperstimulation syndrome	4852.28	47.98	706	3907	3308	63481101
Ascites	740.42	47.98	221	4392	40507	63443902
No adverse event	243.88	47.98	97	4516	41308	63443101
Abdominal distension	235.54	47.98	118	4495	86497	63397912
Ovarian enlargement	206.06	47.98	35	4578	459	63483950
Maternal exposure before pregnancy	167.10	47.98	48	4565	7555	63476854
Haemoperitoneum	151.44	47.98	36	4577	2705	63481704
Product quality issue	140.68	47.98	63	4550	35802	63448607
Pelvic fluid collection	136.50	47.98	27	4586	849	63483560
Ovarian haemorrhage	134.45	47.98	23	4590	315	63484094
Adnexal torsion	134.25	47.98	24	4589	430	63483979
Inappropriate schedule of product administration	126.53	47.98	84	4529	103881	63380528
Product packaging quantity issue	119.08	47.98	26	4587	1333	63483076
Poor quality device used	113.35	47.98	27	4586	2044	63482365
Abortion spontaneous	106.95	47.98	57	4556	47138	63437271
Progesterone increased	92.89	47.98	13	4600	39	63484370
Pleural effusion	91.42	47.98	66	4547	93144	63391265
Haemoconcentration	80.02	47.98	13	4600	127	63484282
Ovarian cyst ruptured	62.34	47.98	15	4598	1184	63483225
Incorrect dose administered	59.96	47.98	43	4570	59925	63424484
Ectopic pregnancy	59.93	47.98	17	4596	2550	63481859
Abdominal pain lower	58.08	47.98	31	4582	25647	63458762
Circumstance or information capable of leading to medication error	57.18	47.98	18	4595	3852	63480557
Abortion missed	56.97	47.98	15	4598	1704	63482705
Abortion	55.89	47.98	16	4597	2480	63481929
Abdominal pain	55.72	47.98	86	4527	293370	63191039
Premature ovulation	51.70	47.98	7	4606	15	63484394
Multiple pregnancy	51.61	47.98	8	4605	56	63484353
Oestradiol decreased	49.08	47.98	7	4606	25	63484384

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ovarian hyperstimulation syndrome	4868.01	55.24	655	2864	2916	79737953
Ascites	682.15	55.24	213	3306	75349	79665520
Ovarian enlargement	233.84	55.24	35	3484	333	79740536
Abdominal distension	185.98	55.24	95	3424	119555	79621314
Pelvic fluid collection	151.78	55.24	27	3492	792	79740077
Adnexal torsion	143.06	55.24	23	3496	360	79740509
Ovarian haemorrhage	140.08	55.24	22	3497	294	79740575
Haemoperitoneum	137.25	55.24	33	3486	4310	79736559
Maternal exposure before pregnancy	111.67	55.24	28	3491	4345	79736524
Progesterone increased	99.63	55.24	13	3506	38	79740831
Pleural effusion	87.84	55.24	63	3456	145199	79595670
Haemoconcentration	75.04	55.24	12	3507	181	79740688
Ovarian cyst ruptured	67.19	55.24	14	3505	952	79739917
Abdominal pain lower	66.50	55.24	31	3488	31751	79709118
Abdominal pain	62.33	55.24	81	3438	389488	79351381
Poor quality device used	60.17	55.24	15	3504	2270	79738599
No adverse event	58.93	55.24	30	3489	37162	79703707
Abortion missed	57.75	55.24	13	3506	1270	79739599
Premature ovulation	56.22	55.24	7	3512	12	79740857
Product quality issue	55.59	55.24	28	3491	33912	79706957

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G03GA04	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM GONADOTROPINS AND OTHER OVULATION STIMULANTS Gonadotropins
ATC	G03GA05	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM GONADOTROPINS AND OTHER OVULATION STIMULANTS Gonadotropins
ATC	G03GA06	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM GONADOTROPINS AND OTHER OVULATION STIMULANTS Gonadotropins
ATC	G03GA10	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM GONADOTROPINS AND OTHER OVULATION STIMULANTS Gonadotropins
FDA CS	M0009540	Gonadotropins
MeSH PA	D006728	Hormones
FDA EPC	N0000175838	Gonadotropin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ovulation induction	indication	61285001

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Induction or superovulation	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Super-Ov	Therio Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Follicle-stimulating hormone receptor	GPCR	P23945	FSHR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D06269	KEGG_DRUG
4019254	VUID
N0000147458	NUI
4019253	VANDF
4019254	VANDF
4021069	VANDF
4021070	VANDF
4024094	VANDF
CHEBI:81569	CHEBI
CHEMBL4297955	ChEMBL_ID
CHEMBL1201692	ChEMBL_ID
CHEMBL2108427	ChEMBL_ID
C000620228	MESH_SUPPLEMENTAL_RECORD_UI
C571801	MESH_SUPPLEMENTAL_RECORD_UI
C571802	MESH_SUPPLEMENTAL_RECORD_UI
DB00066	DRUGBANK_ID
DB00094	DRUGBANK_ID
134404	RXNORM
4760	MMSL
5657	MMSL
7863	MMSL
7864	MMSL
d00570	MMSL
d04043	MMSL
002102	NDDF
006654	NDDF
006941	NDDF
006978	NDDF
103028007	SNOMEDCT_US
109042006	SNOMEDCT_US
109044007	SNOMEDCT_US
126185008	SNOMEDCT_US
25217009	SNOMEDCT_US
325781003	SNOMEDCT_US
395862009	SNOMEDCT_US
395920003	SNOMEDCT_US
725743001	SNOMEDCT_US
763577005	SNOMEDCT_US
768662008	SNOMEDCT_US
C0733758	UMLSCUI
D005640	MESH_DESCRIPTOR_UI
D050477	MESH_DESCRIPTOR_UI
CHEMBL1201520	ChEMBL_ID
9503	INN_ID
9732	INN_ID
1919	INN_ID
7505	INN_ID
4798	INN_ID
62819	PUBCHEM_CID
1157	IUPHAR_LIGAND_ID
076WHW89TW	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	0052-0313	INJECTION, SOLUTION	350 [iU]	SUBCUTANEOUS	BLA	28 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	0052-0313	INJECTION, SOLUTION	350 [iU]	SUBCUTANEOUS	BLA	28 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	0052-0316	INJECTION, SOLUTION	650 [iU]	SUBCUTANEOUS	BLA	28 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	0052-0316	INJECTION, SOLUTION	650 [iU]	SUBCUTANEOUS	BLA	28 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	0052-0326	INJECTION, SOLUTION	975 [iU]	SUBCUTANEOUS	BLA	28 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	0052-0326	INJECTION, SOLUTION	975 [iU]	SUBCUTANEOUS	BLA	28 sections
Gonal-f RFF Redi-ject	HUMAN PRESCRIPTION DRUG LABEL	1	44087-1115	INJECTION, SOLUTION	300 [iU]	SUBCUTANEOUS	BLA	28 sections
Gonal-f RFF Redi-ject	HUMAN PRESCRIPTION DRUG LABEL	1	44087-1116	INJECTION, SOLUTION	450 [iU]	SUBCUTANEOUS	BLA	28 sections
Gonal-f RFF Redi-ject	HUMAN PRESCRIPTION DRUG LABEL	1	44087-1117	INJECTION, SOLUTION	900 [iU]	SUBCUTANEOUS	BLA	28 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	78206-129	INJECTION, SOLUTION	300 [iU]	SUBCUTANEOUS	BLA	27 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	78206-130	INJECTION, SOLUTION	600 [iU]	SUBCUTANEOUS	BLA	27 sections
Follistim AQ	HUMAN PRESCRIPTION DRUG LABEL	1	78206-131	INJECTION, SOLUTION	900 [iU]	SUBCUTANEOUS	BLA	27 sections