Stem definition | Drug id | CAS RN |
---|---|---|
glucagon-like peptide (GLP) analogues and agonists | 4927 | 782500-75-8 |
Dose | Unit | Route |
---|---|---|
5.70 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
April 15, 2014 | FDA | GLAXOSMITHKLINE LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Device use error | 325.71 | 53.06 | 52 | 376 | 5709 | 63482885 |
Device leakage | 60.11 | 53.06 | 13 | 415 | 7083 | 63481511 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Device use error | 215.26 | 57.22 | 34 | 311 | 2341 | 34954245 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Device use error | 288.37 | 49.33 | 50 | 622 | 7051 | 79736665 |
None
Source | Code | Description |
---|---|---|
ATC | A10BJ04 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Glucagon-like peptide-1 (GLP-1) analogues |
FDA MoA | N0000020058 | Glucagon-like Peptide-1 (GLP-1) Agonists |
FDA EPC | N0000178480 | GLP-1 Receptor Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Diabetes mellitus type 2 | indication | 44054006 | DOID:9352 |
Multiple endocrine neoplasia, type 2 | contraindication | 61808009 | |
Medullary thyroid carcinoma | contraindication | 255032005 | DOID:3973 |
History of medullary carcinoma of thyroid | contraindication | 429016002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.01 | acidic |
pKa2 | 3.31 | acidic |
pKa3 | 3.82 | acidic |
pKa4 | 4.11 | acidic |
pKa5 | 4.44 | acidic |
pKa6 | 9.65 | acidic |
pKa7 | 11.88 | acidic |
pKa8 | 12.25 | acidic |
pKa9 | 12.57 | acidic |
pKa10 | 12.65 | acidic |
pKa11 | 12.88 | acidic |
pKa12 | 12.95 | acidic |
pKa13 | 13.05 | acidic |
pKa14 | 13.2 | acidic |
pKa15 | 13.23 | acidic |
pKa16 | 13.38 | acidic |
pKa17 | 13.39 | acidic |
pKa18 | 13.55 | acidic |
pKa19 | 13.56 | acidic |
pKa20 | 13.67 | acidic |
pKa21 | 13.75 | acidic |
pKa22 | 13.8 | acidic |
pKa23 | 13.91 | acidic |
pKa24 | 12.18 | Basic |
pKa25 | 11.11 | Basic |
pKa26 | 10.51 | Basic |
pKa27 | 7.86 | Basic |
pKa28 | 5.98 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucagon-like peptide 1 receptor | GPCR | AGONIST | EC50 | 9.70 | SCIENTIFIC LITERATURE | DRUG LABEL | |||
Glucagon-like peptide 1 receptor | GPCR | AGONIST | EC50 | 7.70 | IUPHAR |
ID | Source |
---|---|
D08843 | KEGG_DRUG |
4033416 | VUID |
N0000190764 | NUI |
4033416 | VANDF |
CHEBI:78425 | CHEBI |
CHEMBL2107841 | ChEMBL_ID |
C534611 | MESH_SUPPLEMENTAL_RECORD_UI |
7386 | IUPHAR_LIGAND_ID |
DB09043 | DRUGBANK_ID |
1534763 | RXNORM |
216723 | MMSL |
30258 | MMSL |
d08251 | MMSL |
015507 | NDDF |
703129009 | SNOMEDCT_US |
703905003 | SNOMEDCT_US |
C2607479 | UMLSCUI |
8829 | INN_ID |
145994868 | PUBCHEM_CID |
5E7U48495E | UNII |
None