felypressin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasoconstrictors, vasopressin derivatives 4910 56-59-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • PLV-2
  • felypressin
  • octapressin
  • octopressin
  • phelypressin
A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.
  • Molecular weight: 1040.23
  • Formula: C46H65N13O11S2
  • CLOGP: -1.07
  • LIPINSKI: 3
  • HAC: 24
  • HDO: 12
  • TPSA: 405.32
  • ALOGS: -4.36
  • ROTB: 19

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:59727 arginine vasopressin receptor agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Local anesthesia indication 386761002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.19 acidic
pKa2 12.56 acidic
pKa3 12.85 acidic
pKa4 13.19 acidic
pKa5 13.71 acidic
pKa6 13.76 acidic
pKa7 13.84 acidic
pKa8 10.31 Basic
pKa9 6.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vasopressin V1a receptor GPCR AGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D04137 KEGG_DRUG
N0000170339 NUI
CHEBI:60564 CHEBI
CHEMBL3989781 ChEMBL_ID
CHEMBL1908309 ChEMBL_ID
1359 INN_ID
DB00093 DRUGBANK_ID
17N2918V6G UNII
14257662 PUBCHEM_CID
4319 RXNORM
004129 NDDF
395943007 SNOMEDCT_US
D005259 MESH_DESCRIPTOR_UI
C0015777 UMLSCUI

Pharmaceutical products:

None