felypressin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vasopressin analogues | 4910 | 56-59-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014662 | Vasoconstrictor Agents |
| CHEBI has role | CHEBI:59727 | arginine vasopressin receptor agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Local anesthesia | indication | 386761002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.19 | acidic |
| pKa2 | 12.56 | acidic |
| pKa3 | 12.85 | acidic |
| pKa4 | 13.19 | acidic |
| pKa5 | 13.71 | acidic |
| pKa6 | 13.76 | acidic |
| pKa7 | 13.84 | acidic |
| pKa8 | 10.31 | Basic |
| pKa9 | 6.4 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Vasopressin V1a receptor | GPCR | AGONIST | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D04137 | KEGG_DRUG |
| N0000170339 | NUI |
| CHEBI:60564 | CHEBI |
| CHEMBL3989781 | ChEMBL_ID |
| CHEMBL1908309 | ChEMBL_ID |
| DB00093 | DRUGBANK_ID |
| 4319 | RXNORM |
| 004129 | NDDF |
| 395943007 | SNOMEDCT_US |
| C0015777 | UMLSCUI |
| D005259 | MESH_DESCRIPTOR_UI |
| 1359 | INN_ID |
| 14257662 | PUBCHEM_CID |
| 17N2918V6G | UNII |
Pharmaceutical products:
None