nintedanib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiogenesis inhibitors 4903 656247-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BIBF1120
  • nibtedanib
  • nintedanib
  • nintedanib esylate
  • intedanib
  • BIBF 1120
  • ofev
  • nintedanib ethanesulfonate
  • vargatef
  • Molecular weight: 539.64
  • Formula: C31H33N5O4
  • CLOGP: 3.08
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 2
  • TPSA: 94.22
  • ALOGS: -4.24
  • ROTB: 8

  • Status: ONP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 15 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 19.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 3, 2015 PMDA Boehringer Ingelheim
Oct. 15, 2014 FDA BOEHRINGER INGELHEIM
Nov. 20, 2014 EMA Boehringer Ingelheim International GmbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 640.38 26.41 620 7535 558982 46118925
Idiopathic pulmonary fibrosis 586.69 26.41 115 8040 1373 46676534
Malignant neoplasm progression 211.66 26.41 135 8020 64791 46613116
Nausea 191.66 26.41 388 7767 687066 45990841
Decreased appetite 149.21 26.41 176 7979 193660 46484247
Vomiting 147.91 26.41 274 7881 452520 46225387
Drug ineffective 73.08 26.41 15 8140 677823 46000084
Death 68.26 26.41 168 7987 335380 46342527
Weight decreased 65.06 26.41 125 8030 210724 46467183
Dyspnoea 57.04 26.41 208 7947 515340 46162567
Liver disorder 46.70 26.41 44 8111 37202 46640705
Stomatitis 41.10 26.41 55 8100 68242 46609665
Non-small cell lung cancer 38.51 26.41 16 8139 3128 46674779
Interstitial lung disease 38.04 26.41 47 8108 53902 46624005
Flatulence 37.90 26.41 35 8120 28843 46649064
Constipation 36.12 26.41 88 8067 174009 46503898
Gamma-glutamyltransferase increased 33.26 26.41 34 8121 31706 46646201
Intestinal haemorrhage 32.05 26.41 14 8141 3094 46674813
Pulmonary embolism 30.52 26.41 62 8093 108523 46569384
Large intestine perforation 30.32 26.41 18 8137 7562 46670345
White blood cell count decreased 30.27 26.41 63 8092 112168 46565739
Neutrophil count decreased 29.27 26.41 37 8118 43389 46634518
Skin reaction 28.88 26.41 20 8135 10926 46666981
Mucosal infection 28.43 26.41 6 8149 105 46677802
Aspartate aminotransferase increased 28.39 26.41 50 8105 78650 46599257
Oxygen saturation decreased 27.65 26.41 46 8109 69118 46608789
Liver function test increased 26.77 26.41 26 8129 22800 46655107
Alanine aminotransferase increased 26.64 26.41 52 8103 88399 46589508
Febrile neutropenia 26.54 26.41 54 8101 94573 46583334

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Idiopathic pulmonary fibrosis 2259.91 22.31 484 12094 3585 29936315
Diarrhoea 1038.25 22.31 952 11626 333151 29606749
Malignant neoplasm progression 436.79 22.31 307 12271 71980 29867920
Decreased appetite 232.06 22.31 299 12279 149611 29790289
Death 172.75 22.31 427 12151 356856 29583044
Weight decreased 142.86 22.31 239 12339 150682 29789218
Pneumothorax 134.21 22.31 84 12494 16109 29923791
Lung transplant 124.99 22.31 42 12536 1874 29938026
Dyspnoea 106.08 22.31 343 12235 332952 29606948
Nausea 102.12 22.31 314 12264 296643 29643257
Abnormal loss of weight 74.70 22.31 35 12543 3767 29936133
Cough 70.73 22.31 160 12418 125482 29814418
Liver disorder 65.05 22.31 71 12507 29651 29910249
Respiratory failure 57.52 22.31 129 12449 100513 29839387
Productive cough 54.45 22.31 65 12513 29888 29910012
Pulmonary embolism 47.84 22.31 103 12475 78032 29861868
Hepatic enzyme increased 45.63 22.31 63 12515 33431 29906469
Drug ineffective 40.77 22.31 50 12528 340337 29599563
Pulmonary fibrosis 38.35 22.31 40 12538 15850 29924050
Pneumonia 36.32 22.31 252 12326 334054 29605846
Abdominal pain upper 35.48 22.31 80 12498 62471 29877429
Pneumonia bacterial 34.81 22.31 30 12548 9373 29930527
Chronic respiratory failure 32.85 22.31 14 12564 1204 29938696
Drug interaction 32.53 22.31 22 12556 199546 29740354
Dysgeusia 31.32 22.31 45 12533 24756 29915144
Lung neoplasm malignant 31.10 22.31 35 12543 15097 29924803
Completed suicide 30.94 22.31 3 12575 99489 29840411
Polyneuropathy 30.77 22.31 31 12547 11792 29928108
Faeces soft 30.57 22.31 16 12562 2183 29937717
Abdominal discomfort 29.46 22.31 64 12514 48727 29891173
Hepatic function abnormal 28.80 22.31 58 12520 41887 29898013
Mesenteric vein thrombosis 28.35 22.31 10 12568 516 29939384
Toxicity to various agents 28.25 22.31 20 12558 177163 29762737
Pulmonary hypertension 27.72 22.31 37 12541 18999 29920901
Pulmonary function test decreased 27.55 22.31 19 12559 4276 29935624
Acute kidney injury 27.04 22.31 46 12532 273796 29666104
Vomiting 25.75 22.31 169 12409 219649 29720251
Gastrointestinal disorder 25.71 22.31 44 12534 28093 29911807
Fatigue 25.49 22.31 225 12353 320448 29619452
Pneumomediastinum 24.81 22.31 13 12565 1778 29938122
Splenic vein thrombosis 24.54 22.31 8 12570 324 29939576
Hypotension 24.43 22.31 29 12549 200536 29739364
General physical health deterioration 23.87 22.31 94 12484 99850 29840050
Epistaxis 23.85 22.31 62 12516 52919 29886981
Constipation 22.91 22.31 101 12477 112805 29827095
Non-small cell lung cancer 22.76 22.31 16 12562 3714 29936186
Overdose 22.73 22.31 4 12574 84333 29855567

Pharmacologic Action:

SourceCodeDescription
ATC L01EX09 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PROTEIN KINASE INHIBITORS
Other protein kinase inhibitors
FDA MoA N0000175076 Protein Kinase Inhibitors
FDA EPC N0000175605 Kinase Inhibitor
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D047428 Protein Kinase Inhibitors
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:38637 tyrosine kinase inhibitors
CHEBI has role CHEBI:48422 angiostatic agents
CHEBI has role CHEBI:63457 fibroblast growth factor receptor antagonists
CHEBI has role CHEBI:65207 vegfr inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Interstitial fibrosis indication 125565008
Non-small cell lung cancer indication 254637007 DOID:3908
Idiopathic pulmonary fibrosis indication 700250006 DOID:0050156

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.97 acidic
pKa2 7.77 Basic
pKa3 3.25 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 100MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL Oct. 15, 2021 TREATMENT OF IDIOPATHIC PULMONULLRY FIBROSIS
EQ 150MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL Oct. 15, 2021 TREATMENT OF IDIOPATHIC PULMONULLRY FIBROSIS
EQ 100MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL Sept. 6, 2022 SLOW THE RATE OF DECLINE IN PULMONULLRY FUNCTION IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE
EQ 150MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL Sept. 6, 2022 SLOW THE RATE OF DECLINE IN PULMONULLRY FUNCTION IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE
EQ 100MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL March 9, 2023 TREATMENT FOR CHRONIC FIBROSING INTERSTITIAL LUNG DISEASES WITH A PROGRESSIVE PHENOTYPE
EQ 150MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL March 9, 2023 TREATMENT FOR CHRONIC FIBROSING INTERSTITIAL LUNG DISEASES WITH A PROGRESSIVE PHENOTYPE
EQ 100MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL Sept. 6, 2026 INDICATED TO SLOW THE RATE OF DECLINE IN PULMONULLRY FUNCTION IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE (SSC-ILD)
EQ 150MG BASE OFEV BOEHRINGER INGELHEIM N205832 Oct. 15, 2014 RX CAPSULE ORAL Sept. 6, 2026 INDICATED TO SLOW THE RATE OF DECLINE IN PULMONULLRY FUNCTION IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE (SSC-ILD)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Platelet-derived growth factor receptor beta Kinase INHIBITOR Kd 7.82 CHEMBL CHEMBL
Fibroblast growth factor receptor 2 Kinase INHIBITOR Kd 6.46 CHEMBL CHEMBL
Fibroblast growth factor receptor 1 Kinase INHIBITOR IC50 7.42 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Fibroblast growth factor receptor 4 Kinase INHIBITOR Kd 5.74 CHEMBL CHEMBL
Platelet-derived growth factor receptor alpha Kinase INHIBITOR IC50 7.74 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Fibroblast growth factor receptor 3 Kinase INHIBITOR Kd 7.03 CHEMBL CHEMBL
Vascular endothelial growth factor receptor 1 Kinase INHIBITOR IC50 6.98 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Vascular endothelial growth factor receptor 3 Kinase INHIBITOR IC50 8.30 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Vascular endothelial growth factor receptor 2 Kinase INHIBITOR IC50 8.30 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Proto-oncogene tyrosine-protein kinase Src Kinase Kd 6.24 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1 Kinase Kd 5.23 CHEMBL
Serine/threonine-protein kinase 35 Kinase Kd 6.09 CHEMBL
Calcium/calmodulin-dependent protein kinase type IV Kinase Kd 5.43 CHEMBL
Insulin receptor Kinase AGONIST Kd 7.62 CHEMBL
SRSF protein kinase 1 Kinase Kd 7.43 CHEMBL
Serine/threonine-protein kinase RIO3 Kinase Kd 7.44 CHEMBL
Hepatocyte growth factor receptor Kinase Kd 6.70 CHEMBL
Casein kinase I isoform epsilon Kinase Kd 6.64 CHEMBL
Myosin-IIIb Kinase Kd 5.57 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 3 Kinase Kd 5.68 CHEMBL
Serine/threonine-protein kinase PAK 3 Kinase Kd 6.68 CHEMBL
Ephrin type-B receptor 4 Kinase Kd 5.96 CHEMBL
Tyrosine-protein kinase JAK2 Kinase Kd 7.85 CHEMBL
Ribosomal protein S6 kinase alpha-6 Kinase Kd 6.64 CHEMBL
MAP/microtubule affinity-regulating kinase 3 Kinase Kd 6.11 CHEMBL
Ribosomal protein S6 kinase alpha-1 Kinase Kd 6.74 CHEMBL
Serine/threonine-protein kinase SBK1 Kinase Kd 6.96 CHEMBL
Mitogen-activated protein kinase kinase kinase 15 Kinase Kd 5.85 CHEMBL
Microtubule-associated serine/threonine-protein kinase 1 Kinase Kd 5.34 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 5 Kinase Kd 8.74 CHEMBL
Tyrosine-protein kinase JAK1 Kinase Kd 8.32 CHEMBL
Casein kinase I isoform delta Kinase Kd 5.89 CHEMBL
Tyrosine-protein kinase ITK/TSK Kinase Kd 6.68 CHEMBL
Homeodomain-interacting protein kinase 3 Kinase Kd 6.07 CHEMBL
Homeodomain-interacting protein kinase 2 Kinase Kd 6.10 CHEMBL
Maternal embryonic leucine zipper kinase Kinase Kd 8.31 CHEMBL
Wee1-like protein kinase Kinase Kd 5.54 CHEMBL
Tyrosine-protein kinase BTK Kinase Kd 6.51 CHEMBL
NUAK family SNF1-like kinase 1 Kinase Kd 6.80 CHEMBL
Serine/threonine-protein kinase D1 Kinase Kd 6 CHEMBL
Mitogen-activated protein kinase kinase kinase 13 Kinase Kd 6.85 CHEMBL
Serine/threonine-protein kinase TBK1 Kinase Kd 6.82 CHEMBL
Serine/threonine-protein kinase ICK Kinase Kd 5.77 CHEMBL
Ephrin type-A receptor 1 Kinase Kd 5.92 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 1 Kinase Kd 7.46 CHEMBL
Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase Kd 5.70 CHEMBL
MAP/microtubule affinity-regulating kinase 4 Kinase Kd 5.70 CHEMBL
Tyrosine-protein kinase Fgr Kinase Kd 6.52 CHEMBL
Serine/threonine-protein kinase OSR1 Kinase Kd 5.89 CHEMBL
Serine/threonine-protein kinase D3 Kinase Kd 6.19 CHEMBL
Serine/threonine-protein kinase Sgk3 Kinase Kd 6 CHEMBL
STE20/SPS1-related proline-alanine-rich protein kinase Kinase Kd 6.28 CHEMBL
Mitogen-activated protein kinase kinase kinase 7 Kinase Kd 8.39 CHEMBL
Dual specificity protein kinase CLK2 Kinase Kd 6.12 CHEMBL
G protein-coupled receptor kinase 7 Kinase Kd 5.92 CHEMBL
Tyrosine-protein kinase FRK Kinase Kd 5.57 CHEMBL
Myosin light chain kinase family member 4 Kinase Kd 6.36 CHEMBL
Homeodomain-interacting protein kinase 1 Kinase Kd 5.89 CHEMBL
Dual specificity protein kinase CLK1 Kinase Kd 8.06 CHEMBL
Dual specificity protein kinase TTK Kinase Kd 7.66 CHEMBL
Ephrin type-A receptor 2 Kinase Kd 5.54 CHEMBL
Ephrin type-A receptor 3 Kinase Kd 5.07 CHEMBL
Serine/threonine-protein kinase 10 Kinase Kd 7.06 CHEMBL
Tyrosine-protein kinase Fer Kinase Kd 7.14 CHEMBL
Serine/threonine-protein kinase 16 Kinase Kd 7.74 CHEMBL
Serine/threonine-protein kinase 17B Kinase Kd 6.17 CHEMBL
Serine/threonine-protein kinase PLK4 Kinase Kd 7.28 CHEMBL
AP2-associated protein kinase 1 Kinase Kd 7.20 CHEMBL
Serine/threonine-protein kinase MARK2 Kinase Kd 5.85 CHEMBL
Tyrosine-protein kinase JAK3 Kinase Kd 8.09 CHEMBL
Ribosomal protein S6 kinase alpha-5 Kinase Kd 6.70 CHEMBL
Casein kinase II subunit alpha' Kinase Kd 6.05 CHEMBL
Tyrosine-protein kinase Yes Kinase Kd 7.10 CHEMBL
Serine/threonine-protein kinase N2 Kinase Kd 5.85 CHEMBL
Tyrosine-protein kinase HCK Kinase Kd 5.28 CHEMBL
Aurora kinase C Kinase Kd 6.72 CHEMBL
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Kinase Kd 6.59 CHEMBL
High affinity nerve growth factor receptor Kinase Kd 8.35 CHEMBL
Ribosomal protein S6 kinase alpha-3 Kinase Kd 7.19 CHEMBL
Homeodomain-interacting protein kinase 4 Kinase Kd 5.92 CHEMBL
Myosin light chain kinase, smooth muscle Kinase Kd 6.54 CHEMBL
Mitogen-activated protein kinase kinase kinase 10 Kinase Kd 5.64 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 5 Kinase Kd 6.41 CHEMBL
Misshapen-like kinase 1 Kinase Kd 7.09 CHEMBL
Leucine-rich repeat serine/threonine-protein kinase 2 Kinase Kd 7.43 CHEMBL
Interleukin-1 receptor-associated kinase 4 Kinase Kd 6.09 CHEMBL
Insulin receptor-related protein Kinase Kd 7.68 CHEMBL
Mast/stem cell growth factor receptor Kit Kinase Kd 8.57 CHEMBL
BMP-2-inducible protein kinase Kinase Kd 8.66 CHEMBL
Serine/threonine-protein kinase PAK 7 Kinase Kd 5.89 CHEMBL
Serine/threonine-protein kinase 17A Kinase Kd 6.96 CHEMBL
Mitogen-activated protein kinase kinase kinase 11 Kinase Kd 6.15 CHEMBL
Insulin-like growth factor 1 receptor Kinase Kd 7.21 CHEMBL
Ephrin type-A receptor 6 Kinase Kd 6.03 CHEMBL
TRAF2 and NCK-interacting protein kinase Kinase Kd 7.28 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 2 Kinase Kd 6.04 CHEMBL
Ribosomal protein S6 kinase alpha-4 Kinase Kd 6.21 CHEMBL
Aurora kinase B Kinase Kd 6.38 CHEMBL
STE20-like serine/threonine-protein kinase Kinase Kd 7.29 CHEMBL
Dual specificity protein kinase CLK4 Kinase Kd 7.74 CHEMBL
Death-associated protein kinase 2 Kinase Kd 5.49 CHEMBL
Non-receptor tyrosine-protein kinase TYK2 Kinase Kd 7.43 CHEMBL
Interleukin-1 receptor-associated kinase 1 Kinase Kd 6.92 CHEMBL
Serine/threonine-protein kinase 4 Kinase Kd 8.05 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 1 Kinase Kd 6.20 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1D Kinase Kd 5.66 CHEMBL
Serine/threonine-protein kinase 3 Kinase Kd 7.42 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1G Kinase Kd 6.59 CHEMBL
5'-AMP-activated protein kinase catalytic subunit alpha-1 Kinase Kd 7.06 CHEMBL
Tyrosine-protein kinase Lyn Kinase Kd 6.03 CHEMBL
Ribosomal protein S6 kinase alpha-2 Kinase Kd 7.24 CHEMBL
Serine/threonine-protein kinase ULK2 Kinase Kd 6.42 CHEMBL
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Kinase Kd 6.85 CHEMBL
Ephrin type-B receptor 1 Kinase Kd 6.26 CHEMBL
Activated CDC42 kinase 1 Kinase Kd 5.80 CHEMBL
Cyclin-dependent kinase 16 Kinase Kd 7.68 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 3 Kinase Kd 6.54 CHEMBL
Focal adhesion kinase 1 Kinase Kd 6.68 CHEMBL
Casein kinase II subunit alpha Kinase Kd 5.12 CHEMBL
NT-3 growth factor receptor Kinase Kd 7.49 CHEMBL
Serine/threonine-protein kinase STK11 Kinase Kd 7.74 CHEMBL
Rhodopsin kinase Kinase Kd 6 CHEMBL
Tyrosine-protein kinase ZAP-70 Kinase Kd 5.46 CHEMBL
Activin receptor type-1 Kinase Kd 6.22 CHEMBL
Interleukin-1 receptor-associated kinase 3 Kinase Kd 5.28 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit alpha Kinase Kd 5.44 CHEMBL
G protein-coupled receptor kinase 4 Kinase Kd 7.77 CHEMBL
Mitogen-activated protein kinase kinase kinase 2 Kinase Kd 8.03 CHEMBL
Cyclin-dependent kinase 2 Kinase Kd 5.85 CHEMBL
Serine/threonine-protein kinase ULK3 Kinase Kd 7.22 CHEMBL
Abelson tyrosine-protein kinase 2 Kinase Kd 5.70 CHEMBL
Serine/threonine-protein kinase MARK1 Kinase Kd 5.85 CHEMBL
Serine/threonine-protein kinase 26 Kinase Kd 7.31 CHEMBL
Bone morphogenetic protein receptor type-2 Kinase Kd 7.25 CHEMBL
Protein-tyrosine kinase 2-beta Kinase Kd 7.09 CHEMBL
Tyrosine-protein kinase Blk Kinase Kd 6.42 CHEMBL
Serine/threonine-protein kinase LATS2 Kinase Kd 6.42 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit alpha Kinase Kd 5.35 CHEMBL
Angiopoietin-1 receptor Kinase Kd 5.85 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit epsilon Kinase Kd 6.77 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Kd 5.80 CHEMBL
Serine/threonine-protein kinase PRP4 homolog Kinase Kd 8.08 CHEMBL
Proto-oncogene tyrosine-protein kinase ROS Kinase Kd 5.43 CHEMBL
Ephrin type-B receptor 6 Kinase Kd 6.85 CHEMBL
Mitogen-activated protein kinase 8 Kinase Kd 6.20 CHEMBL
Serine/threonine-protein kinase SIK2 Kinase Kd 6.55 CHEMBL
Cyclin-dependent kinase 7 Kinase Kd 6.52 CHEMBL
Serine/threonine-protein kinase 24 Kinase Kd 6.96 CHEMBL
5'-AMP-activated protein kinase catalytic subunit alpha-2 Kinase Kd 7.08 CHEMBL
Tyrosine-protein kinase Fyn Kinase Kd 6.20 CHEMBL
Macrophage colony-stimulating factor 1 receptor Kinase Kd 7.32 CHEMBL
Uncharacterized serine/threonine-protein kinase SBK3 Kinase Kd 5.70 CHEMBL
Discoidin domain-containing receptor 2 Kinase Kd 7.38 CHEMBL
Cyclin-dependent kinase 17 Kinase Kd 7.03 CHEMBL
Death-associated protein kinase 3 Kinase Kd 5.68 CHEMBL
Serine/threonine-protein kinase receptor R3 Kinase Kd 5.38 CHEMBL
Activin receptor type-1B Kinase Kd 5.31 CHEMBL
Tyrosine-protein kinase receptor Tie-1 Kinase Kd 5.66 CHEMBL
TGF-beta receptor type-1 Kinase Kd 5.38 CHEMBL
Serine/threonine-protein kinase PAK 4 Kinase Kd 5.52 CHEMBL
Serine/threonine-protein kinase DCLK3 Kinase Kd 6.11 CHEMBL
Cyclin-dependent kinase 14 Kinase Kd 6.33 CHEMBL
Eukaryotic translation initiation factor 2-alpha kinase 4 Kinase Kd 5.70 CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase Kd 8.02 CHEMBL
Epithelial discoidin domain-containing receptor 1 Kinase Kd 7.92 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 4 Kinase Kd 6.82 CHEMBL
Cyclin-dependent kinase 18 Kinase Kd 6.29 CHEMBL
Serine/threonine-protein kinase LATS1 Kinase Kd 6.38 CHEMBL
Serine/threonine-protein kinase PAK 2 Kinase Kd 5.48 CHEMBL
Tyrosine-protein kinase receptor TYRO3 Kinase Kd 5.31 CHEMBL
Tyrosine-protein kinase Fes/Fps Kinase Kd 5.92 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 8.21 CHEMBL
Myosin light chain kinase 2, skeletal/cardiac muscle Kinase Kd 5.40 CHEMBL
Mitogen-activated protein kinase kinase kinase 9 Kinase Kd 6.66 CHEMBL
Leukocyte tyrosine kinase receptor Kinase Kd 6.82 CHEMBL
Mitogen-activated protein kinase kinase kinase 19 Kinase Kd 8.28 CHEMBL
Tyrosine-protein kinase receptor UFO Kinase Kd 7.92 CHEMBL
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Kinase Kd 7.77 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase Kd 5.55 CHEMBL
Serine/threonine-protein kinase D2 Kinase Kd 6.14 CHEMBL
BDNF/NT-3 growth factors receptor Kinase Kd 7.72 CHEMBL
NUAK family SNF1-like kinase 2 Kinase Kd 7.68 CHEMBL
SRSF protein kinase 2 Kinase Kd 7.44 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 2 Kinase Kd 7.38 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 4 Kinase Kd 5.43 CHEMBL
SRSF protein kinase 3 Kinase Kd 7.92 CHEMBL
Tyrosine-protein kinase TXK Kinase Kd 6.07 CHEMBL
ALK tyrosine kinase receptor Kinase Kd 7.51 CHEMBL
Mitogen-activated protein kinase kinase kinase 12 Kinase Kd 6.85 CHEMBL
Myosin light chain kinase 3 Kinase Kd 6.96 CHEMBL
Receptor-interacting serine/threonine-protein kinase 1 Kinase Kd 6.62 CHEMBL
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Kinase Kd 7.31 CHEMBL
Mitogen-activated protein kinase kinase kinase 3 Kinase Kd 7.47 CHEMBL
Serine/threonine-protein kinase RIO1 Kinase Kd 7.64 CHEMBL
Cyclin-dependent kinase 4 Kinase Kd 6.80 CHEMBL
Ribosomal protein S6 kinase beta-1 Kinase Kd 6.72 CHEMBL
Serine/threonine-protein kinase ULK1 Kinase Kd 6.47 CHEMBL
Serine/threonine-protein kinase 33 Kinase Kd 5.96 CHEMBL
Testis-specific serine/threonine-protein kinase 1 Kinase Kd 5.21 CHEMBL
Glycogen synthase kinase-3 beta Kinase Kd 7.08 CHEMBL
Serine/threonine-protein kinase Chk1 Kinase Kd 6.54 CHEMBL
Glycogen synthase kinase-3 alpha Kinase Kd 6.37 CHEMBL
cGMP-dependent protein kinase 1 Kinase Kd 7.85 CHEMBL
Receptor-interacting serine/threonine-protein kinase 4 Kinase Kd 6.36 CHEMBL
Serine/threonine-protein kinase N1 Kinase Kd 6.13 CHEMBL
Serine/threonine-protein kinase SIK1 Kinase Kd 6.17 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 2 Kinase Kd 6.54 CHEMBL
Tyrosine-protein kinase Mer Kinase Kd 8.07 CHEMBL
Mitogen-activated protein kinase 7 Kinase Kd 5.60 CHEMBL
Non-receptor tyrosine-protein kinase TNK1 Kinase Kd 6.68 CHEMBL
Mitogen-activated protein kinase 10 Kinase Kd 6.57 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 1 Kinase Kd 8 CHEMBL
Tyrosine-protein kinase ABL1 Kinase Kd 8 CHEMBL
Cyclin-dependent kinase-like 2 Kinase Kd 5.89 CHEMBL
Receptor-type tyrosine-protein kinase FLT3 Kinase Kd 9.38 CHEMBL
Protein kinase C theta type Kinase Kd 5.26 CHEMBL
Serine/threonine-protein kinase DCLK1 Kinase Kd 6.27 CHEMBL
Muscle, skeletal receptor tyrosine-protein kinase Kinase Kd 6.23 CHEMBL
Serine/threonine-protein kinase PknB Kinase Kd 8.44 CHEMBL
Calcium-dependent protein kinase 1 Kinase Kd 5.92 CHEMBL
Vascular endothelial growth factor receptor 2 Kinase IC50 7.89 CHEMBL

External reference:

IDSource
D10396 KEGG_DRUG
4033814 VUID
N0000191096 NUI
656247-18-6 SECONDARY_CAS_RN
4033814 VANDF
C1879771 UMLSCUI
CHEBI:85164 CHEBI
XIN PDB_CHEM_ID
CHEMBL502835 ChEMBL_ID
CHEMBL3039504 ChEMBL_ID
DB09079 DRUGBANK_ID
C530716 MESH_SUPPLEMENTAL_RECORD_UI
135423438 PUBCHEM_CID
5936 IUPHAR_LIGAND_ID
9229 INN_ID
G6HRD2P839 UNII
1592736 RXNORM
229920 MMSL
30617 MMSL
d08301 MMSL
015720 NDDF
015723 NDDF
712494002 SNOMEDCT_US
715613009 SNOMEDCT_US
863993005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ofev HUMAN PRESCRIPTION DRUG LABEL 1 0597-0143 CAPSULE 100 mg ORAL NDA 31 sections
Ofev HUMAN PRESCRIPTION DRUG LABEL 1 0597-0145 CAPSULE 150 mg ORAL NDA 31 sections