imidafenacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
muscarinic receptors antagonists 4902 170105-16-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • imidafenacin
  • uritos
  • KRP-197
  • KRP 197
  • Molecular weight: 319.41
  • Formula: C20H21N3O
  • CLOGP: 2.22
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 60.91
  • ALOGS: -4.53
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.51 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 2007 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bladder muscle dysfunction - overactive indication 236633002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.68 acidic
pKa2 6.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Kb 9.50 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Muscarinic acetylcholine receptor M1 GPCR Kb 8.38 SCIENTIFIC LITERATURE

External reference:

IDSource
D06273 KEGG_DRUG
6433090 PUBCHEM_CID
CHEBI:134720 CHEBI
CHEMBL53366 ChEMBL_ID
DB09262 DRUGBANK_ID
XJR8Y07LJO UNII
8402 INN_ID
C120953 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None