imidafenacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| muscarinic receptors antagonists | 4902 | 170105-16-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1.51 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 6.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.20 hours | Lombardo F, Berellini G, Obach RS |
| BA (Bioavailability) | 0.58 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 18, 2007 | PMDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G04BD14 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS UROLOGICALS Drugs for urinary frequency and incontinence |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bladder muscle dysfunction - overactive | indication | 236633002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.68 | acidic |
| pKa2 | 6.35 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | Kb | 9.50 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Muscarinic acetylcholine receptor M1 | GPCR | Kb | 8.38 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| XJR8Y07LJO | UNII |
| D06273 | KEGG_DRUG |
| C1876226 | UMLSCUI |
| CHEBI:134720 | CHEBI |
| CHEMBL53366 | ChEMBL_ID |
| 6433090 | PUBCHEM_CID |
| DB09262 | DRUGBANK_ID |
| 8402 | INN_ID |
| C120953 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None