luseogliflozin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives 4891 898537-18-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • luseogliflozin
  • lusefi
  • luseogliflozin hydrate
  • TS-071
an antidiabetic agent that inhibits sodium-dependent glucose cotransporter 2 (SGLT2)
  • Molecular weight: 434.55
  • Formula: C23H30O6S
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 99.38
  • ALOGS: -3.93
  • ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 24, 2014 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BK07 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.22 acidic
pKa2 13.21 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.65 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1 Transporter IC50 5.40 SCIENTIFIC LITERATURE

External reference:

IDSource
D10195 KEGG_DRUG
C4045533 UMLSCUI
CHEBI:134725 CHEBI
DB12214 DRUGBANK_ID
C549343 MESH_SUPPLEMENTAL_RECORD_UI
9292 INN_ID
C596HWF74Z UNII
11988953 PUBCHEM_CID

Pharmaceutical products:

None