DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
luseogliflozin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives
4891
898537-18-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
luseogliflozin
lusefi
luseogliflozin hydrate
TS-071
an antidiabetic agent that inhibits sodium-dependent glucose cotransporter 2 (SGLT2)
Molecular weight: 434.55
Formula: C23H30O6S
CLOGP: 3.35
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 99.38
ALOGS: -3.93
ROTB: 7
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
March 24, 2014
PMDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A10BK07
ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Diabetes mellitus type 2
indication
44054006
DOID:9352
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
12.22
acidic
pKa2
13.21
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Sodium/glucose cotransporter 2
Transporter
P31639
SC5A2_HUMAN
INHIBITOR
IC50
8.65
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1
Transporter
P13866
SC5A1_HUMAN
IC50
5.40
SCIENTIFIC LITERATURE
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External reference:
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ID
Source
11988953
PUBCHEM_CID
9292
INN_ID
C2933904
UMLSCUI
C549343
MESH_SUPPLEMENTAL_RECORD_UI
C596HWF74Z
UNII
CHEBI:134725
CHEBI
D10195
KEGG_DRUG
DB12214
DRUGBANK_ID
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Pharmaceutical products:
None
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luseogliflozin