ipragliflozin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives 4890 761423-87-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ipragliflozin
  • suglat
  • ipragliflozin L-proline
  • ASP1941
  • Molecular weight: 404.45
  • Formula: C21H21FO5S
  • CLOGP: 3.38
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 90.15
  • ALOGS: -4.13
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 2014 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BK05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D000077203 Sodium-Glucose Transporter 2 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.62 acidic
pKa2 13.26 acidic
pKa3 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.13 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1 Transporter IC50 5.73 SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1 Transporter INHIBITOR IC50 5.86 IUPHAR
Sodium/glucose cotransporter 1 Transporter INHIBITOR IC50 5.93 IUPHAR
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.25 IUPHAR
Sodium/glucose cotransporter 2 Transporter INHIBITOR IC50 8.20 IUPHAR

External reference:

IDSource
D10196 KEGG_DRUG
951382-34-6 SECONDARY_CAS_RN
C4742129 UMLSCUI
CHEBI:134724 CHEBI
CHEMBL2018096 ChEMBL_ID
CHEMBL4297658 ChEMBL_ID
DB11698 DRUGBANK_ID
10453870 PUBCHEM_CID
C572941 MESH_SUPPLEMENTAL_RECORD_UI
9394 IUPHAR_LIGAND_ID
9258 INN_ID
3N2N8OOR7X UNII

Pharmaceutical products:

None