DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
ipragliflozin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
sodium glucose co-transporter inhibitors, phlorizin derivatives
4890
761423-87-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
ipragliflozin
suglat
ipragliflozin L-proline
ASP1941
Molecular weight: 404.45
Formula: C21H21FO5S
CLOGP: 3.38
LIPINSKI: 0
HAC: 5
HDO: 4
TPSA: 90.15
ALOGS: -4.13
ROTB: 4
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Jan. 17, 2014
PMDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cerebral infarction
54.34
38.15
17
445
45659
79698267
Diabetes mellitus inadequate control
41.66
38.15
12
450
24252
79719674
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A10BK05
ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sodium-glucose co-transporter 2 (SGLT2) inhibitors
MeSH PA
D007004
Hypoglycemic Agents
MeSH PA
D000077203
Sodium-Glucose Transporter 2 Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Diabetes mellitus type 2
indication
44054006
DOID:9352
Diabetes mellitus type 1
indication
46635009
DOID:9744
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
11.62
acidic
pKa2
13.26
acidic
pKa3
13.7
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Sodium/glucose cotransporter 2
Transporter
P31639
SC5A2_HUMAN
INHIBITOR
IC50
8.13
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 1
Transporter
P13866
SC5A1_HUMAN
IC50
5.73
SCIENTIFIC LITERATURE
Sodium/glucose cotransporter 2
Transporter
SC5A2_RAT
INHIBITOR
IC50
8.20
IUPHAR
Sodium/glucose cotransporter 1
Transporter
SC5A1_MOUSE
INHIBITOR
IC50
5.86
IUPHAR
Sodium/glucose cotransporter 1
Transporter
SC5A1_RAT
INHIBITOR
IC50
5.93
IUPHAR
Sodium/glucose cotransporter 2
Transporter
SC5A2_MOUSE
INHIBITOR
IC50
8.25
IUPHAR
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External reference:
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ID
Source
10453870
PUBCHEM_CID
3N2N8OOR7X
UNII
9258
INN_ID
9394
IUPHAR_LIGAND_ID
951382-34-6
SECONDARY_CAS_RN
C3492889
UMLSCUI
C572941
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:134724
CHEBI
CHEMBL2018096
ChEMBL_ID
CHEMBL4297658
ChEMBL_ID
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Pharmaceutical products:
None
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ipragliflozin