carbamazepine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tricyclic compounds 489 298-46-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbamazepine
  • carbamazepen
  • carbamazepin
  • carbazepine
  • carbamazepine dihydrate
  • carbamazepine hydrate
  • carbamazepine hydrochloride
  • carbamazepine sulfate
  • carbamazepine anhydrous
  • carbamazepine phosphate
  • carbamazepine tartrate
A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
  • Molecular weight: 236.27
  • Formula: C15H12N2O
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.33
  • ALOGS: -3.19
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O
1 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.26 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 113.00 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 11, 1968 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1288.10 10.43 1221 68149 121833 46494859
Epilepsy 873.24 10.43 504 68866 23234 46593458
Drug reaction with eosinophilia and systemic symptoms 668.15 10.43 461 68909 29087 46587605
Abortion spontaneous 437.89 10.43 424 68946 43222 46573470
Generalised tonic-clonic seizure 415.38 10.43 335 69035 26787 46589905
Drug interaction 369.26 10.43 883 68487 202211 46414481
Anticonvulsant drug level increased 351.01 10.43 116 69254 1304 46615388
Toxicity to various agents 347.20 10.43 885 68485 210881 46405811
Maternal exposure during pregnancy 329.03 10.43 565 68805 101984 46514708
Status epilepticus 303.84 10.43 213 69157 13766 46602926
Stevens-Johnson syndrome 293.19 10.43 257 69113 23040 46593652
Hyponatraemia 263.70 10.43 510 68860 100822 46515870
Rheumatoid arthritis 258.44 10.43 28 69342 240187 46376505
Trigeminal neuralgia 241.17 10.43 108 69262 2881 46613811
Ataxia 228.04 10.43 179 69191 13751 46602941
Diarrhoea 218.61 10.43 309 69061 559293 46057399
Petit mal epilepsy 199.75 10.43 97 69273 3123 46613569
Dyspnoea 197.96 10.43 288 69082 515260 46101432
Overdose 188.72 10.43 447 68923 101532 46515160
Drug level increased 188.28 10.43 181 69189 18260 46598432
Sedation 186.62 10.43 199 69171 22711 46593981
Diplopia 178.65 10.43 180 69190 19225 46597467
Partial seizures 172.50 10.43 102 69268 4908 46611784
Psychotic disorder 171.16 10.43 189 69181 22432 46594260
Cognitive disorder 170.98 10.43 241 69129 36642 46580050
Nystagmus 170.41 10.43 106 69264 5593 46611099
Somnolence 164.56 10.43 559 68811 155962 46460730
Balance disorder 164.36 10.43 322 69048 64199 46552493
Exposure during pregnancy 160.27 10.43 436 68934 107776 46508916
Suicide attempt 159.20 10.43 290 69080 54746 46561946
Coma 158.19 10.43 299 69071 58050 46558642
Depressed level of consciousness 152.21 10.43 262 69108 47307 46569385
Focal dyscognitive seizures 151.17 10.43 77 69293 2751 46613941
Sedation complication 149.01 10.43 83 69287 3562 46613130
Drug eruption 144.03 10.43 168 69202 21161 46595531
Intentional overdose 133.68 10.43 297 69073 64647 46552045
Gamma-glutamyltransferase increased 133.39 10.43 198 69172 31542 46585150
Drug level decreased 132.92 10.43 92 69278 5820 46610872
Arthralgia 132.59 10.43 211 69159 364392 46252300
Stillbirth 120.70 10.43 90 69280 6401 46610291
Hypomania 114.75 10.43 75 69295 4313 46612379
Joint swelling 112.52 10.43 53 69317 166020 46450672
Anticonvulsant drug level above therapeutic 112.35 10.43 38 69332 461 46616231
Electroencephalogram abnormal 110.16 10.43 69 69301 3685 46613007
Inappropriate antidiuretic hormone secretion 108.70 10.43 119 69251 13983 46602709
Peripheral swelling 107.77 10.43 50 69320 158021 46458671
Fatigue 105.14 10.43 507 68863 608190 46008502
Rash maculo-papular 104.60 10.43 165 69205 27709 46588983
Aggression 104.47 10.43 148 69222 22596 46594096
Infusion related reaction 100.94 10.43 15 69355 101193 46515499
Schizophrenia 100.76 10.43 91 69279 8477 46608215
Dysarthria 100.16 10.43 191 69179 37307 46579385
Death 99.98 10.43 219 69151 335329 46281363
Toxic epidermal necrolysis 97.97 10.43 142 69228 22136 46594556
Myoclonic epilepsy 92.94 10.43 39 69331 884 46615808
Creatinine renal clearance decreased 90.37 10.43 78 69292 6842 46609850
Jaundice cholestatic 89.66 10.43 68 69302 4961 46611731
Febrile neutropenia 87.80 10.43 17 69353 94610 46522082
Altered state of consciousness 85.93 10.43 137 69233 23211 46593481
Lymphocyte stimulation test positive 85.51 10.43 33 69337 597 46616095
Product complaint 81.16 10.43 95 69275 12006 46604686
Sinusitis 81.05 10.43 46 69324 129722 46486970
Anticonvulsant drug level below therapeutic 79.71 10.43 31 69339 573 46616119
Abnormal behaviour 79.48 10.43 125 69245 20933 46595759
Contraindicated product administered 79.37 10.43 12 69358 79935 46536757
Acute kidney injury 78.69 10.43 144 69226 235711 46380981
Anaemia 77.72 10.43 165 69205 255614 46361078
Synovitis 77.58 10.43 3 69367 61072 46555620
Aura 77.10 10.43 35 69335 964 46615728
Back pain 75.76 10.43 122 69248 209917 46406775
Erythema multiforme 74.98 10.43 82 69288 9622 46607070
Loss of consciousness 74.84 10.43 339 69031 107899 46508793
Orthostatic hypotension 73.89 10.43 132 69238 24526 46592166
Abortion induced 72.93 10.43 83 69287 10177 46606515
Nausea 71.11 10.43 667 68703 686787 45929905
Human herpes virus 6 serology positive 70.85 10.43 19 69351 95 46616597
Eosinophilia 69.67 10.43 112 69258 19105 46597587
Completed suicide 69.58 10.43 412 68958 145508 46471184
Abdominal discomfort 68.61 10.43 74 69296 151091 46465601
Psychogenic seizure 67.76 10.43 34 69336 1176 46615516
Lymphocyte morphology abnormal 67.54 10.43 25 69345 401 46616291
Temporal lobe epilepsy 66.38 10.43 24 69346 359 46616333
Intellectual disability 65.95 10.43 28 69342 654 46616038
Hyperammonaemia 65.34 10.43 55 69315 4661 46612031
Hepatic function abnormal 64.78 10.43 152 69218 34269 46582423
Blood calcium decreased 64.72 10.43 97 69273 15576 46601116
Alopecia 64.72 10.43 88 69282 162326 46454366
Anticonvulsant drug level decreased 63.97 10.43 33 69337 1211 46615481
Arthropathy 63.84 10.43 23 69347 84677 46532015
Product dose omission issue 62.54 10.43 96 69274 168424 46448268
Pain in extremity 62.20 10.43 188 69182 258492 46358200
Oral mucosa erosion 62.13 10.43 31 69339 1059 46615633
Cerebellar syndrome 62.10 10.43 47 69323 3418 46613274
Product substitution issue 62.03 10.43 93 69277 14938 46601754
Bradyphrenia 61.41 10.43 60 69310 6170 46610522
Pyrexia 60.97 10.43 788 68582 348014 46268678
Myoclonus 60.95 10.43 90 69280 14262 46602430
Dysmorphism 60.91 10.43 37 69333 1870 46614822
Drug abuse 60.90 10.43 220 69150 63188 46553504
Pregnancy 60.23 10.43 128 69242 27009 46589683
Speech disorder 58.81 10.43 151 69219 36016 46580676
Swelling 58.69 10.43 59 69311 124452 46492240
Lip erosion 55.44 10.43 26 69344 773 46615919
Pain 55.26 10.43 449 68921 476499 46140193
Neuroleptic malignant syndrome 54.99 10.43 75 69295 11047 46605645
Atrial fibrillation 54.91 10.43 44 69326 103546 46513146
Hyperammonaemic encephalopathy 54.59 10.43 35 69335 1947 46614745
Dermatitis exfoliative 54.39 10.43 54 69316 5662 46611030
Cough 53.44 10.43 170 69200 230079 46386613
Gastric lavage 53.22 10.43 13 69357 41 46616651
Nasopharyngitis 53.13 10.43 92 69278 153906 46462786
Sopor 51.71 10.43 100 69270 19728 46596964
Pneumonia 49.87 10.43 341 69029 375979 46240713
Cardiac failure congestive 48.59 10.43 39 69331 91711 46524981
Foetal anticonvulsant syndrome 48.38 10.43 20 69350 436 46616256
Oculomucocutaneous syndrome 48.26 10.43 15 69355 136 46616556
Histiocytosis 47.73 10.43 10 69360 11 46616681
Hypotonia 47.68 10.43 60 69310 8169 46608523
Tonic convulsion 47.44 10.43 26 69344 1080 46615612
Injection site pain 46.91 10.43 54 69316 107098 46509594
Chest pain 46.89 10.43 122 69248 176202 46440490
Multiple-drug resistance 46.43 10.43 35 69335 2530 46614162
Human herpesvirus 6 infection 45.75 10.43 34 69336 2405 46614287
Coordination abnormal 45.55 10.43 68 69302 10881 46605811
Multiple sclerosis relapse 45.51 10.43 152 69218 41973 46574719
Abdominal pain 44.66 10.43 183 69187 229848 46386844
Drug intolerance 44.48 10.43 95 69275 146954 46469738
Pemphigus 44.46 10.43 7 69363 45267 46571425
Mucosal erosion 44.33 10.43 27 69343 1371 46615321
Nikolsky's sign 43.49 10.43 13 69357 102 46616590
Infection 43.23 10.43 83 69287 133509 46483183
Neuropathy peripheral 42.90 10.43 43 69327 90850 46525842
Treatment failure 42.85 10.43 45 69325 93042 46523650
Extrapyramidal disorder 42.67 10.43 67 69303 11201 46605491
Ovarian granulosa-theca cell tumour 42.64 10.43 10 69360 25 46616667
Sudden unexplained death in epilepsy 42.32 10.43 16 69354 273 46616419
Drug resistance 42.15 10.43 85 69285 17283 46599409
Normal newborn 41.73 10.43 48 69322 5953 46610739
Developmental glaucoma 41.53 10.43 11 69359 52 46616640
Face oedema 40.96 10.43 89 69281 19064 46597628
Arthritis 40.77 10.43 33 69337 77283 46539409
Meningomyelocele 40.26 10.43 18 69352 478 46616214
Hand deformity 39.87 10.43 3 69367 34571 46582121
Change in seizure presentation 39.62 10.43 15 69355 257 46616435
Gastrointestinal haemorrhage 39.59 10.43 34 69336 77339 46539353
Confusional state 39.57 10.43 387 68983 159505 46457187
Lymphadenopathy 39.02 10.43 124 69246 33364 46583328
Injection site erythema 38.95 10.43 32 69338 74395 46542297
Febrile convulsion 38.74 10.43 16 69354 348 46616344
Myocardial infarction 38.67 10.43 53 69317 97475 46519217
Angiofibroma 38.59 10.43 12 69358 109 46616583
Teratogenicity 38.30 10.43 12 69358 112 46616580
Behaviour disorder 38.28 10.43 28 69342 1933 46614759
Irritability 38.24 10.43 112 69258 28834 46587858
Vertigo 38.19 10.43 166 69204 51882 46564810
Blood lactate dehydrogenase increased 37.99 10.43 90 69280 20410 46596282
Foetal exposure during pregnancy 37.81 10.43 116 69254 30631 46586061
Simple partial seizures 37.81 10.43 18 69352 554 46616138
Bronchitis 37.75 10.43 62 69308 105917 46510775
Psoriasis 37.31 10.43 37 69333 78567 46538125
Hippocampal sclerosis 37.29 10.43 11 69359 82 46616610
Osteoarthritis 37.27 10.43 23 69347 62002 46554690
Influenza 36.93 10.43 47 69323 89223 46527469
Malignant neoplasm progression 36.42 10.43 26 69344 64900 46551792
Angiomyolipoma 36.04 10.43 13 69357 193 46616499
Dyspnoea exertional 35.66 10.43 15 69355 50274 46566418
Facial pain 35.57 10.43 50 69320 7575 46609117
Obsessive-compulsive disorder 35.56 10.43 33 69337 3182 46613510
Lower respiratory tract infection 35.13 10.43 19 69351 55070 46561622
Asthma 35.04 10.43 51 69319 91491 46525201
Psoriatic arthropathy 34.88 10.43 6 69364 36373 46580319
Maternal drugs affecting foetus 34.82 10.43 42 69328 5476 46611216
Abdominal pain upper 33.88 10.43 107 69263 145198 46471494
Hypogammaglobulinaemia 33.68 10.43 41 69329 5397 46611295
Fulminant type 1 diabetes mellitus 33.49 10.43 13 69357 239 46616453
Gastrooesophageal reflux disease 33.04 10.43 37 69333 74307 46542385
Oscillopsia 33.01 10.43 11 69359 127 46616565
Restlessness 32.99 10.43 98 69272 25426 46591266
Agitation 32.78 10.43 166 69204 55249 46561443
Hepatotoxicity 32.30 10.43 96 69274 24913 46591779
Headache 32.11 10.43 509 68861 477843 46138849
Toxic skin eruption 31.72 10.43 62 69308 12325 46604367
Aphasia 31.67 10.43 104 69266 28463 46588229
Therapeutic product effect decreased 31.63 10.43 46 69324 82555 46534137
Injection site pruritus 31.31 10.43 10 69360 39733 46576959
Mania 31.13 10.43 57 69313 10789 46605903
Chest discomfort 31.05 10.43 54 69316 90215 46526477
Epistaxis 30.83 10.43 30 69340 64275 46552417
Atonic seizures 30.60 10.43 16 69354 604 46616088
Intentional self-injury 30.49 10.43 92 69278 24074 46592618
Injection site swelling 30.29 10.43 11 69359 40316 46576376
Osteonecrosis of jaw 30.21 10.43 7 69363 34395 46582297
Hallucination, auditory 30.21 10.43 56 69314 10700 46605992
Partial seizures with secondary generalisation 30.18 10.43 13 69357 315 46616377
Nephrogenic diabetes insipidus 30.17 10.43 17 69353 746 46615946
Bone pain 30.15 10.43 16 69354 46874 46569818
Coma scale abnormal 29.80 10.43 37 69333 4969 46611723
Self esteem decreased 29.68 10.43 15 69355 527 46616165
Spina bifida 29.57 10.43 16 69354 648 46616044
Central nervous system lesion 29.48 10.43 52 69318 9563 46607129
Diabetes insipidus 29.39 10.43 25 69345 2149 46614543
Psychomotor skills impaired 29.27 10.43 25 69345 2161 46614531
Urinary incontinence 29.10 10.43 101 69269 28429 46588263
Bipolar disorder 29.03 10.43 44 69326 7133 46609559
Blood alkaline phosphatase increased 28.80 10.43 126 69244 39483 46577209
Poisoning 28.76 10.43 64 69306 13930 46602762
Off label use 28.64 10.43 395 68975 379446 46237246
Convulsive threshold lowered 28.61 10.43 13 69357 359 46616333
Intentional product use issue 28.48 10.43 22 69348 52758 46563934
Wound 28.43 10.43 14 69356 42788 46573904
Systemic lupus erythematosus 28.35 10.43 33 69337 65147 46551545
Urinary tract infection 27.92 10.43 202 69168 220064 46396628
Hyporeflexia 27.84 10.43 23 69347 1899 46614793
Catatonia 27.70 10.43 31 69339 3731 46612961
Paradoxical drug reaction 27.47 10.43 25 69345 2351 46614341
Product use issue 27.09 10.43 63 69307 94581 46522111
Antipsychotic drug level decreased 26.93 10.43 10 69360 162 46616530
Learning disorder 26.84 10.43 13 69357 416 46616276
Dizziness 26.67 10.43 678 68692 339736 46276956
Lymphangioleiomyomatosis 26.59 10.43 10 69360 168 46616524
Blood creatine phosphokinase increased 26.44 10.43 96 69274 27628 46589064
Weight decreased 26.42 10.43 194 69176 210655 46406037
Gaze palsy 26.40 10.43 19 69351 1279 46615413
Injection site bruising 26.30 10.43 10 69360 35626 46581066
Fall 26.23 10.43 657 68713 328440 46288252
Conversion disorder 26.03 10.43 21 69349 1677 46615015
Eosinophil count increased 26.02 10.43 44 69326 7822 46608870
Disease progression 25.95 10.43 61 69309 91239 46525453
Stupor 25.91 10.43 29 69341 3491 46613201
Musculoskeletal stiffness 25.88 10.43 68 69302 97925 46518767
Hospitalisation 25.57 10.43 34 69336 63351 46553341
Device expulsion 25.42 10.43 5 69365 27537 46589155
SUNCT syndrome 25.22 10.43 5 69365 3 46616689
Cerebral atrophy 25.15 10.43 33 69337 4683 46612009
Conjunctival hyperaemia 25.12 10.43 22 69348 1967 46614725
General physical health deterioration 25.09 10.43 88 69282 115681 46501011
Productive cough 25.08 10.43 23 69347 50692 46566000
Thinking abnormal 24.98 10.43 49 69321 9765 46606927
Diverticulitis 24.84 10.43 9 69361 33030 46583662
Eye movement disorder 24.73 10.43 33 69337 4760 46611932
Plasma cell myeloma 24.69 10.43 18 69352 44460 46572232
Shock 24.64 10.43 80 69290 21765 46594927
Mental impairment 24.52 10.43 56 69314 12400 46604292
Psychomotor hyperactivity 24.47 10.43 48 69322 9565 46607127
Fluid retention 24.25 10.43 24 69346 51022 46565670
Genital erosion 24.16 10.43 9 69361 147 46616545
Hypersensitivity 24.16 10.43 128 69242 150193 46466499
Blood hyposmosis 24.09 10.43 6 69364 21 46616671
Musculoskeletal pain 24.07 10.43 42 69328 70086 46546606
Pleural effusion 23.91 10.43 55 69315 82897 46533795
Erythema 23.73 10.43 320 69050 142500 46474192
Caesarean section 23.63 10.43 66 69304 16537 46600155
Dyspepsia 23.51 10.43 41 69329 68431 46548261
Pulmonary arterial hypertension 23.33 10.43 5 69365 25923 46590769
Injection site reaction 23.31 10.43 22 69348 47827 46568865
Wheezing 23.25 10.43 27 69343 53359 46563333
Anaemia megaloblastic 23.24 10.43 11 69359 334 46616358
Chronic obstructive pulmonary disease 23.16 10.43 31 69339 57602 46559090
Gait disturbance 23.13 10.43 323 69047 144940 46471752
Autism spectrum disorder 23.10 10.43 13 69357 569 46616123
Polydipsia psychogenic 22.97 10.43 7 69363 59 46616633
Ophthalmoplegia 22.81 10.43 15 69355 871 46615821
Amnesia 22.74 10.43 122 69248 41509 46575183
Illusion 22.72 10.43 16 69354 1040 46615652
Epileptic psychosis 22.54 10.43 6 69364 29 46616663
Mental disorder 22.53 10.43 79 69291 22346 46594346
Deafness congenital 22.43 10.43 5 69365 9 46616683
Areflexia 22.41 10.43 25 69345 2998 46613694
Mitochondrial enzyme deficiency 22.37 10.43 6 69364 30 46616662
Palpitations 22.29 10.43 70 69300 95189 46521503
Terminal insomnia 22.29 10.43 12 69358 481 46616211
Ear malformation 22.26 10.43 9 69361 185 46616507
Dexamethasone suppression test positive 22.05 10.43 4 69366 0 46616692
Neurotoxicity 22.01 10.43 57 69313 13660 46603032
Epileptic aura 21.91 10.43 7 69363 70 46616622
Apathy 21.88 10.43 39 69331 7229 46609463
Suicidal ideation 21.77 10.43 151 69219 56231 46560461
Tremor 21.70 10.43 265 69105 115374 46501318
Hyperthermia 21.61 10.43 41 69329 7973 46608719
Hepatitis 21.56 10.43 100 69270 32115 46584577
Condition aggravated 21.56 10.43 496 68874 244556 46372136
Blood sodium decreased 21.37 10.43 76 69294 21650 46595042
Neuromyelitis optica spectrum disorder 21.28 10.43 14 69356 814 46615878
Hypertension 21.22 10.43 188 69182 196168 46420524
Sepsis 21.20 10.43 117 69253 135897 46480795
Disturbance in attention 21.15 10.43 98 69272 31462 46585230
Lymphocytosis 21.06 10.43 21 69349 2213 46614479
Upper respiratory tract infection 20.97 10.43 39 69331 63517 46553175
Stereotypy 20.97 10.43 11 69359 418 46616274
Glossodynia 20.92 10.43 21 69349 44352 46572340
Peripheral nerve decompression 20.91 10.43 5 69365 14 46616678
Chronic kidney disease 20.85 10.43 18 69352 40853 46575839
Loss of personal independence in daily activities 20.78 10.43 33 69337 57150 46559542
Polydipsia 20.76 10.43 25 69345 3254 46613438
Hyperkalaemia 20.66 10.43 27 69343 50682 46566010
Disorganised speech 20.63 10.43 14 69356 857 46615835
Full blood count decreased 20.57 10.43 4 69366 22207 46594485
Septic shock 20.48 10.43 34 69336 57859 46558833
Rheumatoid factor positive 20.46 10.43 3 69367 20458 46596234
Skin exfoliation 20.41 10.43 100 69270 32838 46583854
Renal failure 20.40 10.43 93 69277 113501 46503191
Clostridium difficile infection 20.34 10.43 6 69364 25097 46591595
Hepatocellular injury 20.02 10.43 92 69278 29430 46587262
Alanine aminotransferase increased 19.89 10.43 210 69160 88241 46528451
Conjunctivitis 19.72 10.43 59 69311 15365 46601327
Colitis 19.61 10.43 16 69354 37331 46579361
Pseudolymphoma 19.58 10.43 12 69358 616 46616076
Pyuria 19.58 10.43 18 69352 1715 46614977
Delusion 19.53 10.43 48 69322 11140 46605552
Dyskinesia 19.51 10.43 90 69280 28835 46587857
Haemoglobin decreased 19.51 10.43 112 69258 128837 46487855
Oedema peripheral 19.49 10.43 148 69222 159558 46457134
Respiratory depression 19.44 10.43 49 69321 11551 46605141
Pulmonary hypertension 19.42 10.43 15 69355 35978 46580714
Congenital spinal fusion 19.29 10.43 4 69366 4 46616688
Medication error 19.27 10.43 94 69276 30817 46585875
Unintended pregnancy 19.18 10.43 32 69338 5628 46611064
Benzodiazepine drug level increased 19.04 10.43 8 69362 182 46616510
Toxic encephalopathy 19.03 10.43 30 69340 5032 46611660
Encapsulating peritoneal sclerosis 19.01 10.43 10 69360 382 46616310
Impaired healing 18.97 10.43 16 69354 36727 46579965
Anaphylactic reaction 18.97 10.43 31 69339 53081 46563611
Pericarditis 18.88 10.43 6 69364 23921 46592771
Cleft lip 18.76 10.43 7 69363 115 46616577
Persecutory delusion 18.72 10.43 21 69349 2534 46614158
Adverse drug reaction 18.71 10.43 23 69347 44339 46572353
Blister 18.71 10.43 122 69248 44509 46572183
Microcephaly 18.58 10.43 12 69358 676 46616016
Myalgia 18.58 10.43 107 69263 122981 46493711
Dehydration 18.46 10.43 150 69220 159390 46457302
Cellulitis 18.38 10.43 49 69321 70239 46546453
Sensorimotor disorder 18.32 10.43 10 69360 412 46616280
Nasal congestion 18.21 10.43 27 69343 48086 46568606
Herpes zoster 17.99 10.43 47 69323 67825 46548867
Wrong drug 17.92 10.43 7 69363 131 46616561
Intra-abdominal pressure increased 17.91 10.43 8 69362 212 46616480
Drug level above therapeutic 17.86 10.43 24 69346 3485 46613207
Joint stiffness 17.80 10.43 9 69361 27099 46589593
Therapeutic product effective for unapproved indication 17.80 10.43 6 69364 72 46616620
Mucosal inflammation 17.75 10.43 19 69351 38957 46577735
Interstitial granulomatous dermatitis 17.74 10.43 5 69365 31 46616661
Sinus arrest 17.68 10.43 17 69353 1714 46614978
Memory impairment 17.57 10.43 184 69186 77153 46539539
Abortion threatened 17.53 10.43 11 69359 589 46616103
Oxygen saturation decreased 17.50 10.43 49 69321 69115 46547577
Bursitis 17.50 10.43 4 69366 19838 46596854
Psychiatric symptom 17.39 10.43 27 69343 4470 46612222
Blood osmolarity decreased 17.38 10.43 12 69358 756 46615936
Encephalocele 17.35 10.43 7 69363 143 46616549
Hip arthroplasty 17.34 10.43 3 69367 18109 46598583
Pregnancy with implant contraceptive 17.31 10.43 18 69352 1994 46614698
Dystonia 17.27 10.43 46 69324 11211 46605481
Thrombosis 17.12 10.43 36 69334 56033 46560659
Acinetobacter test positive 17.09 10.43 6 69364 82 46616610
Slow speech 17.05 10.43 15 69355 1349 46615343
Rectal haemorrhage 17.03 10.43 19 69351 38236 46578456
Medulloblastoma 16.98 10.43 5 69365 37 46616655
Skin erosion 16.95 10.43 19 69351 2290 46614402
Hot flush 16.89 10.43 24 69346 43493 46573199
Knee arthroplasty 16.87 10.43 7 69363 23658 46593034
Mood altered 16.86 10.43 50 69320 12957 46603735
Rhinorrhoea 16.85 10.43 28 69342 47637 46569055
Pulmonary valve stenosis congenital 16.83 10.43 7 69363 155 46616537
Rhesus incompatibility 16.83 10.43 6 69364 86 46616606
Developmental delay 16.82 10.43 14 69356 1168 46615524
Hypoproteinaemia 16.78 10.43 17 69353 1826 46614866
Hypomagnesaemia 16.78 10.43 6 69364 22204 46594488
Injection site haemorrhage 16.69 10.43 5 69365 20704 46595988
Osteomalacia 16.62 10.43 11 69359 646 46616046
Periodic limb movement disorder 16.55 10.43 7 69363 162 46616530
Lymphocyte transformation test positive 16.54 10.43 3 69367 0 46616692
Tensilon test abnormal 16.54 10.43 3 69367 0 46616692
Ammonia increased 16.54 10.43 26 69344 4351 46612341
Product dispensing error 16.53 10.43 40 69330 9193 46607499
Urticaria vesiculosa 16.53 10.43 4 69366 12 46616680
Gingival hypertrophy 16.45 10.43 15 69355 1414 46615278
Sciatica 16.45 10.43 4 69366 19016 46597676
Acid base balance abnormal 16.34 10.43 8 69362 262 46616430
Asterixis 16.32 10.43 14 69356 1217 46615475
Seizure cluster 16.23 10.43 7 69363 170 46616522
Lennox-Gastaut syndrome 16.15 10.43 8 69362 269 46616423
Disorientation 16.14 10.43 102 69268 36816 46579876
Rash 16.10 10.43 665 68705 355847 46260845
Pulmonary embolism 16.06 10.43 95 69275 108490 46508202
Developmental regression 16.06 10.43 4 69366 14 46616678
Blood pressure fluctuation 16.04 10.43 13 69357 30435 46586257
Rash morbilliform 15.96 10.43 21 69349 2988 46613704
Petechiae 15.76 10.43 48 69322 12622 46604070
Therapeutic response unexpected 15.68 10.43 55 69315 15561 46601131
Abortion 15.65 10.43 18 69352 2232 46614460
Human herpesvirus 6 infection reactivation 15.64 10.43 4 69366 16 46616676
Respiratory tract infection 15.54 10.43 13 69357 29959 46586733
Fibromyalgia 15.28 10.43 19 69351 36444 46580248
Epidermolysis bullosa 15.28 10.43 6 69364 114 46616578
Near drowning 15.26 10.43 4 69366 18 46616674
Cardiac failure 15.23 10.43 64 69306 79884 46536808
Adverse event 15.19 10.43 17 69353 34167 46582525
Neonatal seizure 15.18 10.43 8 69362 307 46616385
Therapeutic product ineffective for unapproved indication 15.15 10.43 7 69363 201 46616491
Pneumonitis 15.14 10.43 12 69358 28408 46588284
Facial neuralgia 15.08 10.43 6 69364 118 46616574
Blood immunoglobulin A decreased 14.85 10.43 8 69362 321 46616371
Genital burning sensation 14.78 10.43 7 69363 213 46616479
Lethargy 14.72 10.43 128 69242 51043 46565649
Affective disorder 14.71 10.43 26 69344 4789 46611903
Ideas of reference 14.68 10.43 5 69365 62 46616630
Blood bilirubin increased 14.67 10.43 94 69276 34090 46582602
Vitamin D deficiency 14.62 10.43 43 69327 11091 46605601
Anal erosion 14.60 10.43 4 69366 22 46616670
Haemorrhage 14.53 10.43 38 69332 54831 46561861
Cerebellar atrophy 14.47 10.43 10 69360 631 46616061
Urinary tract malformation 14.47 10.43 3 69367 3 46616689
Personality change due to a general medical condition 14.45 10.43 4 69366 23 46616669
Derailment 14.40 10.43 5 69365 66 46616626
Bradycardia 14.25 10.43 156 69214 66142 46550550
Vaginal ulceration 14.22 10.43 8 69362 350 46616342
Brugada syndrome 14.20 10.43 7 69363 233 46616459
Papule 14.17 10.43 24 69346 4271 46612421
Localised infection 14.05 10.43 9 69361 23792 46592900
Vanishing bile duct syndrome 14.01 10.43 10 69360 664 46616028
Cytomegalovirus mucocutaneous ulcer 14.00 10.43 3 69367 4 46616688
Respiratory arrest 13.91 10.43 92 69278 33724 46582968
Renal impairment 13.88 10.43 60 69310 74312 46542380
Labelled drug-drug interaction medication error 13.87 10.43 37 69333 9024 46607668
Developmental hip dysplasia 13.86 10.43 13 69357 1270 46615422
Pigmentation disorder 13.86 10.43 22 69348 3711 46612981
Drug level below therapeutic 13.79 10.43 20 69350 3117 46613575
Hypometabolism 13.78 10.43 4 69366 28 46616664
Aspartate aminotransferase increased 13.75 10.43 178 69192 78522 46538170
Epileptic encephalopathy 13.74 10.43 7 69363 250 46616442
Coronary artery disease 13.72 10.43 18 69352 33734 46582958
Pseudophaeochromocytoma 13.69 10.43 5 69365 77 46616615
Muscle spasms 13.67 10.43 117 69253 122996 46493696
Metabolic disorder 13.62 10.43 24 69346 4408 46612284
Eyelid oedema 13.60 10.43 40 69330 10317 46606375
Purpura 13.60 10.43 39 69331 9919 46606773
Dysphagia 13.57 10.43 175 69195 77137 46539555
Skin ulcer 13.51 10.43 17 69353 32441 46584251
Hepatitis A 13.49 10.43 8 69362 387 46616305
Congenital cystic kidney disease 13.49 10.43 8 69362 387 46616305
Bacteriuria 13.46 10.43 10 69360 707 46615985
Pharyngeal erythema 13.46 10.43 14 69356 1551 46615141
Tooth development disorder 13.42 10.43 4 69366 31 46616661
Ultrasound ovary abnormal 13.41 10.43 5 69365 82 46616610
Blood pressure increased 13.35 10.43 122 69248 126544 46490148
Congenital megaureter 13.35 10.43 5 69365 83 46616609
Poverty of speech 13.32 10.43 7 69363 267 46616425
Throat irritation 13.26 10.43 14 69356 28887 46587805
Hyperglycinaemia 13.25 10.43 3 69367 6 46616686
Pulmonary venous thrombosis 13.25 10.43 3 69367 6 46616686
Odynophagia 13.17 10.43 30 69340 6632 46610060
Hypoglycaemia neonatal 13.12 10.43 11 69359 927 46615765
Dry mouth 13.10 10.43 40 69330 54886 46561806
Speech disorder developmental 13.09 10.43 8 69362 409 46616283
Skin test positive 13.08 10.43 10 69360 738 46615954
Paranoia 13.04 10.43 40 69330 10557 46606135
Thyroid adenoma 12.96 10.43 6 69364 173 46616519
Mouth ulceration 12.91 10.43 76 69294 26756 46589936
Vaginal erosion 12.90 10.43 4 69366 36 46616656
Cholelithiasis 12.87 10.43 100 69270 38581 46578111
Pneumatosis 12.86 10.43 8 69362 422 46616270
Trance 12.70 10.43 4 69366 38 46616654
Decreased appetite 12.69 10.43 207 69163 193629 46423063
Haemorrhoids 12.68 10.43 6 69364 18771 46597921
Neonatal hypotension 12.68 10.43 5 69365 96 46616596
Selective IgG subclass deficiency 12.65 10.43 3 69367 8 46616684
Discomfort 12.61 10.43 32 69338 46638 46570054
Abdominal distension 12.60 10.43 61 69309 73290 46543402
Hyperlactacidaemia 12.59 10.43 16 69354 2199 46614493
Hirsutism 12.57 10.43 11 69359 983 46615709
Congenital foot malformation 12.50 10.43 6 69364 188 46616504
Brain injury 12.49 10.43 28 69342 6122 46610570
COVID-19 12.45 10.43 6 69364 18569 46598123
Neurosis 12.45 10.43 7 69363 306 46616386
Basilar migraine 12.43 10.43 4 69366 41 46616651
Gastrointestinal disorder 12.42 10.43 46 69324 59530 46557162
Persistent depressive disorder 12.39 10.43 11 69359 1001 46615691
Carnitine decreased 12.39 10.43 3 69367 9 46616683
Haematochezia 12.37 10.43 23 69347 37470 46579222
Enanthema 12.35 10.43 8 69362 453 46616239
Limb malformation 12.35 10.43 8 69362 453 46616239
Oral mucosal eruption 12.29 10.43 9 69361 622 46616070
Arnold-Chiari malformation 12.29 10.43 8 69362 457 46616235
Wrong patient received product 12.25 10.43 14 69356 1723 46614969
Skin oedema 12.24 10.43 10 69360 813 46615879
Negative thoughts 12.22 10.43 10 69360 815 46615877
Tearfulness 12.21 10.43 22 69348 4113 46612579
Nodule 12.16 10.43 4 69366 15601 46601091
Lymphopenia 12.16 10.43 50 69320 15243 46601449
Neoplasm progression 12.16 10.43 13 69357 26670 46590022
Aortic bypass 12.16 10.43 3 69367 10 46616682
Fabry's disease 12.16 10.43 3 69367 10 46616682
Tuberous sclerosis complex 12.16 10.43 3 69367 10 46616682
Disease recurrence 12.11 10.43 57 69313 18414 46598278
Quadriparesis 12.08 10.43 14 69356 1750 46614942
Congenital hydrocephalus 12.05 10.43 5 69365 110 46616582
Acanthosis 11.97 10.43 5 69365 112 46616580
Autoimmune hypothyroidism 11.97 10.43 5 69365 112 46616580
Echopraxia 11.94 10.43 3 69367 11 46616681
Psychomotor retardation 11.93 10.43 19 69351 3214 46613478
Throat tightness 11.92 10.43 8 69362 20631 46596061
Cardiac disorder 11.90 10.43 30 69340 43828 46572864
Musculoskeletal chest pain 11.90 10.43 6 69364 18100 46598592
Eye discharge 11.82 10.43 24 69346 4904 46611788
Logorrhoea 11.80 10.43 16 69354 2343 46614349
Poisoning deliberate 11.77 10.43 32 69338 7894 46608798
Fungal infection 11.73 10.43 16 69354 29504 46587188
Juvenile myoclonic epilepsy 11.73 10.43 3 69367 12 46616680
Euphoric mood 11.69 10.43 22 69348 4250 46612442
Congenital anomaly 11.65 10.43 13 69357 1559 46615133
Pulmonary mass 11.62 10.43 6 69364 17851 46598841
Cataract 11.62 10.43 32 69338 45383 46571309
Posterior reversible encephalopathy syndrome 11.59 10.43 4 69366 15137 46601555
Joint range of motion decreased 11.57 10.43 4 69366 15120 46601572
Drug withdrawal convulsions 11.54 10.43 12 69358 1329 46615363
Urine calcium decreased 11.54 10.43 3 69367 13 46616679
Nervous system disorder 11.49 10.43 51 69319 16078 46600614
Unevaluable event 11.47 10.43 33 69337 46142 46570550
Cerebellar ataxia 11.42 10.43 10 69360 894 46615798
Kidney duplex 11.37 10.43 4 69366 55 46616637
Acantholysis 11.36 10.43 3 69367 14 46616678
Conjunctival erosion 11.36 10.43 3 69367 14 46616678
Hyperphosphatasaemia 11.36 10.43 3 69367 14 46616678
Blood immunoglobulin M decreased 11.34 10.43 9 69361 702 46615990
Drug dependence 11.33 10.43 59 69311 19842 46596850
Trigeminal nerve disorder 11.32 10.43 5 69365 129 46616563
Mitral valve incompetence 11.31 10.43 7 69363 18845 46597847
Neurological examination abnormal 11.29 10.43 6 69364 234 46616458
Altered visual depth perception 11.26 10.43 7 69363 369 46616323
Lactate pyruvate ratio increased 11.24 10.43 4 69366 57 46616635
Hepatitis fulminant 11.21 10.43 19 69351 3383 46613309
Anal atresia 11.20 10.43 7 69363 372 46616320
Enlarged cerebral perivascular spaces 11.19 10.43 3 69367 15 46616677
Multiple sclerosis 11.15 10.43 69 69301 24722 46591970
Flatulence 11.13 10.43 16 69354 28862 46587830
Accidental overdose 11.09 10.43 59 69311 20007 46596685
Neutropenia 11.08 10.43 148 69222 143056 46473636
Haematemesis 11.06 10.43 16 69354 28790 46587902
Acute myocardial infarction 11.06 10.43 19 69351 31905 46584787
Intervertebral disc degeneration 11.05 10.43 3 69367 13249 46603443
Transfusion 11.02 10.43 3 69367 13228 46603464
Growth retardation 10.95 10.43 10 69360 945 46615747
Cardiac arrest 10.94 10.43 192 69178 90207 46526485
Angiosclerosis 10.87 10.43 3 69367 17 46616675
Drug dose titration not performed 10.87 10.43 7 69363 392 46616300
Sinus congestion 10.87 10.43 3 69367 13106 46603586
Peritonitis 10.72 10.43 9 69361 20705 46595987
Gastric ulcer 10.71 10.43 10 69360 21853 46594839
Inhibitory drug interaction 10.70 10.43 14 69356 1981 46614711
Lip ulceration 10.68 10.43 13 69357 1710 46614982
Papillary thyroid cancer 10.67 10.43 14 69356 1987 46614705
Premature labour 10.66 10.43 39 69331 11260 46605432
Device dislocation 10.65 10.43 10 69360 21792 46594900
Myelodysplastic syndrome 10.64 10.43 5 69365 15706 46600986
Postictal state 10.63 10.43 10 69360 981 46615711
Conjunctival oedema 10.63 10.43 8 69362 577 46616115
Postictal psychosis 10.59 10.43 3 69367 19 46616673
Lymphadenitis 10.58 10.43 16 69354 2589 46614103
Skin lesion 10.58 10.43 72 69298 26641 46590051
Premature baby 10.52 10.43 54 69316 18058 46598634
Gastroenteritis viral 10.50 10.43 7 69363 18112 46598580
Basal cell carcinoma 10.48 10.43 9 69361 20478 46596214
Dementia 10.48 10.43 47 69323 14883 46601809
Respiratory tract congestion 10.44 10.43 3 69367 12761 46603931

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1191.12 11.12 1148 52310 97327 29801693
Drug reaction with eosinophilia and systemic symptoms 663.74 11.12 486 52972 28002 29871018
Epilepsy 654.18 11.12 422 53036 19747 29879273
Generalised tonic-clonic seizure 359.60 11.12 290 53168 19261 29879759
Anticonvulsant drug level increased 330.40 11.12 118 53340 1397 29897623
Status epilepticus 266.89 11.12 193 53265 10879 29888141
Aggression 227.32 11.12 304 53154 36603 29862417
Ataxia 221.31 11.12 175 53283 11287 29887733
Stevens-Johnson syndrome 209.79 11.12 204 53254 17352 29881668
Death 190.61 11.12 215 53243 357068 29541952
Drug interaction 172.18 11.12 758 52700 198810 29700210
Drug eruption 171.77 11.12 183 53275 17343 29881677
Trigeminal neuralgia 148.82 11.12 57 53401 831 29898189
Gamma-glutamyltransferase increased 148.36 11.12 220 53238 29130 29869890
Somnolence 145.81 11.12 441 53017 96322 29802698
Diarrhoea 134.54 11.12 245 53213 333858 29565162
Nystagmus 131.27 11.12 87 53371 4251 29894769
Dyspnoea 124.94 11.12 255 53203 333040 29565980
Toxicity to various agents 124.88 11.12 635 52823 176548 29722472
Acute kidney injury 122.94 11.12 187 53271 273655 29625365
Coordination abnormal 120.94 11.12 102 53356 7203 29891817
Electroencephalogram abnormal 116.76 11.12 65 53393 2309 29896711
Febrile neutropenia 112.91 11.12 26 53432 106667 29792353
Partial seizures 112.66 11.12 75 53383 3692 29895328
Hyponatraemia 109.46 11.12 315 53143 66887 29832133
Petit mal epilepsy 107.91 11.12 64 53394 2567 29896453
Pneumonia 103.50 11.12 283 53175 334023 29564997
Rash maculo-papular 102.75 11.12 172 53286 25246 29873774
Sudden unexplained death in epilepsy 101.71 11.12 36 53422 414 29898606
Lymphocyte stimulation test positive 100.77 11.12 43 53415 840 29898180
Drug level increased 99.14 11.12 142 53316 18212 29880808
Eosinophilia 97.75 11.12 156 53302 22004 29877016
Human herpes virus 6 serology positive 93.94 11.12 26 53432 120 29898900
Focal dyscognitive seizures 93.31 11.12 46 53412 1267 29897753
Anaemia 91.34 11.12 144 53314 207848 29691172
Sopor 89.16 11.12 104 53354 10887 29888133
Lymphadenopathy 85.56 11.12 155 53303 24221 29874799
Myocardial infarction 85.37 11.12 60 53398 125565 29773455
Cardiac failure congestive 84.57 11.12 23 53435 84384 29814636
Abnormal behaviour 82.50 11.12 157 53301 25466 29873554
Diplopia 80.99 11.12 111 53347 13661 29885359
Overdose 79.87 11.12 330 53128 84007 29815013
Psychogenic seizure 75.75 11.12 26 53432 271 29898749
Agitation 75.35 11.12 240 53218 53833 29845187
Gastric lavage 74.63 11.12 14 53444 0 29899020
Drug level decreased 74.13 11.12 70 53388 5735 29893285
Dysmorphism 72.28 11.12 45 53413 1972 29897048
Anticonvulsant drug level above therapeutic 71.74 11.12 27 53431 374 29898646
Intentional self-injury 70.60 11.12 103 53355 13429 29885591
Dysarthria 70.35 11.12 163 53295 30327 29868693
Atrial fibrillation 69.12 11.12 55 53403 108069 29790951
Toxic epidermal necrolysis 68.00 11.12 118 53340 17822 29881198
Anticonvulsant drug level decreased 67.39 11.12 34 53424 985 29898035
Irritability 66.65 11.12 135 53323 22915 29876105
Rash 65.93 11.12 575 52883 191314 29707706
Fatigue 65.72 11.12 322 53136 320351 29578669
Lymphocyte morphology abnormal 64.79 11.12 27 53431 496 29898524
Dermatitis exfoliative 61.22 11.12 71 53387 7385 29891635
Hyperammonaemia 60.09 11.12 61 53397 5459 29893561
Sepsis 59.88 11.12 106 53352 146289 29752731
Decreased eye contact 59.13 11.12 24 53434 411 29898609
Mania 58.75 11.12 77 53381 9077 29889943
Bruxism 58.21 11.12 34 53424 1325 29897695
Arthralgia 57.65 11.12 96 53362 135695 29763325
Oppositional defiant disorder 57.48 11.12 23 53435 379 29898641
Psychomotor retardation 56.23 11.12 41 53417 2338 29896682
Loss of consciousness 56.08 11.12 285 53173 79090 29819930
Altered state of consciousness 55.62 11.12 115 53343 19804 29879216
Rheumatoid arthritis 55.13 11.12 5 53453 41192 29857828
Suicide attempt 54.91 11.12 167 53291 36530 29862490
Multiple-drug resistance 54.81 11.12 44 53414 2897 29896123
Hypotension 54.52 11.12 180 53278 200385 29698635
Autism spectrum disorder 53.73 11.12 32 53426 1293 29897727
Toxic skin eruption 53.38 11.12 81 53377 10934 29888086
Product dose omission issue 53.23 11.12 51 53407 91580 29807440
Renal failure 53.07 11.12 93 53365 128873 29770147
Coma 52.25 11.12 175 53283 40274 29858746
Gait disturbance 50.39 11.12 265 53193 74512 29824508
Paraplegia 50.00 11.12 40 53418 2621 29896399
Hypospadias 49.76 11.12 40 53418 2639 29896381
Cerebellar syndrome 49.32 11.12 36 53422 2056 29896964
Plasma cell myeloma 47.45 11.12 18 53440 53444 29845576
Sedation 47.45 11.12 96 53362 16277 29882743
Intentional overdose 46.27 11.12 171 53287 41310 29857710
Malignant neoplasm progression 45.88 11.12 37 53421 72250 29826770
Aura 45.81 11.12 18 53440 282 29898738
Gastrointestinal haemorrhage 45.55 11.12 49 53409 83397 29815623
Skin test positive 45.44 11.12 19 53439 352 29898668
Foetal exposure during pregnancy 45.40 11.12 157 53301 36714 29862306
Dyskinesia 45.26 11.12 112 53346 21722 29877298
Congenital nail disorder 44.76 11.12 11 53447 28 29898992
Human herpesvirus 6 infection 44.60 11.12 33 53425 1925 29897095
Nausea 44.03 11.12 330 53128 296627 29602393
Psychomotor hyperactivity 43.48 11.12 63 53395 8161 29890859
Erythema multiforme 43.43 11.12 62 53396 7923 29891097
Joint swelling 43.03 11.12 15 53443 46931 29852089
Plasmapheresis 43.03 11.12 18 53440 334 29898686
Drug resistance 42.50 11.12 104 53354 20029 29878991
Cognitive disorder 42.40 11.12 115 53343 23575 29875445
Product complaint 42.26 11.12 52 53406 5754 29893266
Postictal psychosis 42.18 11.12 13 53445 93 29898927
Back pain 42.18 11.12 74 53384 102522 29796498
Coronary artery disease 42.06 11.12 18 53440 49694 29849326
Homicidal ideation 42.02 11.12 35 53423 2428 29896592
Head circumference abnormal 41.62 11.12 11 53447 41 29898979
Choreoathetosis 41.47 11.12 24 53434 919 29898101
Skin exfoliation 40.99 11.12 112 53346 23060 29875960
Hypotonia 40.85 11.12 56 53402 6892 29892128
Exposure during pregnancy 40.56 11.12 65 53393 9196 29889824
Peripheral swelling 40.36 11.12 30 53428 61044 29837976
Balance disorder 40.33 11.12 150 53308 36343 29862677
Conjunctival hyperaemia 40.31 11.12 33 53425 2234 29896786
Depressed level of consciousness 39.68 11.12 154 53304 38068 29860952
Neuroleptic malignant syndrome 39.66 11.12 89 53369 16206 29882814
Alanine aminotransferase increased 39.40 11.12 247 53211 74029 29824991
Inappropriate antidiuretic hormone secretion 39.26 11.12 72 53386 11350 29887670
Weight decreased 39.23 11.12 138 53320 150783 29748237
Dehydration 39.22 11.12 103 53355 123436 29775584
Face oedema 38.40 11.12 71 53387 11263 29887757
Postictal paralysis 38.27 11.12 13 53445 131 29898889
Aspartate aminotransferase increased 37.52 11.12 217 53241 63205 29835815
Chest pain 37.39 11.12 98 53360 117529 29781491
Vertigo 36.69 11.12 106 53352 22529 29876491
Oral mucosa erosion 36.45 11.12 21 53437 797 29898223
Eosinophil count increased 36.28 11.12 55 53403 7418 29891602
Simple partial seizures 35.63 11.12 15 53443 283 29898737
Anticonvulsant drug level below therapeutic 35.23 11.12 19 53439 633 29898387
Foetal anticonvulsant syndrome 34.84 11.12 20 53438 754 29898266
Apathy 34.80 11.12 49 53409 6183 29892837
Abdominal pain 34.60 11.12 125 53333 135529 29763491
Agnosia 34.53 11.12 10 53448 56 29898964
Speech disorder 34.29 11.12 109 53349 24403 29874617
Roseolovirus test positive 34.19 11.12 11 53447 92 29898928
Psychotic disorder 34.15 11.12 100 53358 21415 29877605
Hepatic adenoma 33.96 11.12 9 53449 34 29898986
Blood lactate dehydrogenase increased 33.90 11.12 97 53361 20504 29878516
Neuropathy peripheral 33.57 11.12 46 53412 70429 29828591
Hepatic function abnormal 33.46 11.12 156 53302 41789 29857231
Cellulitis 32.19 11.12 22 53436 46762 29852258
Myalgia 31.77 11.12 55 53403 76612 29822408
Lymphocytic infiltration 31.29 11.12 17 53441 575 29898445
Off label use 31.02 11.12 290 53168 249000 29650020
Cardiac failure 30.92 11.12 64 53394 83354 29815666
Dyspraxia 30.89 11.12 13 53445 245 29898775
Chest discomfort 30.48 11.12 22 53436 45458 29853562
Altered pitch perception 30.34 11.12 7 53451 12 29899008
Disease progression 29.84 11.12 61 53397 79813 29819207
Septic shock 29.81 11.12 42 53416 63565 29835455
Crying 29.70 11.12 43 53415 5566 29893454
Dysmetria 29.60 11.12 14 53444 351 29898669
Myoclonus 29.42 11.12 70 53388 13242 29885778
Psoriasis 29.23 11.12 20 53438 42486 29856534
Mucosal erosion 29.19 11.12 18 53440 775 29898245
Neurodevelopmental disorder 29.19 11.12 11 53447 153 29898867
Acute myocardial infarction 28.97 11.12 31 53427 52908 29846112
Oedema peripheral 28.68 11.12 95 53363 105737 29793283
Erythema 28.56 11.12 236 53222 77215 29821805
Intellectual disability 28.28 11.12 18 53440 820 29898200
Lip erosion 28.12 11.12 16 53442 593 29898427
Product substitution issue 28.08 11.12 58 53400 9977 29889043
Liver disorder 27.84 11.12 116 53342 29606 29869414
Hospitalisation 27.72 11.12 23 53435 44296 29854724
Mucosal inflammation 27.50 11.12 10 53448 30484 29868536
Pain 27.38 11.12 188 53270 172453 29726567
Prostate cancer 27.04 11.12 5 53453 23952 29875068
Medication error 26.42 11.12 90 53368 20882 29878138
Blood alkaline phosphatase increased 25.77 11.12 118 53340 31369 29867651
Facial pain 25.75 11.12 23 53435 1754 29897266
Low birth weight baby 25.72 11.12 42 53416 6034 29892986
Non-24-hour sleep-wake disorder 25.71 11.12 7 53451 30 29898990
Tonic convulsion 25.54 11.12 17 53441 836 29898184
Epileptic aura 25.41 11.12 6 53452 12 29899008
Disturbance in attention 25.32 11.12 92 53366 22037 29876983
Frontotemporal dementia 24.96 11.12 11 53447 233 29898787
Meningocele 24.83 11.12 7 53451 35 29898985
Epistaxis 24.81 11.12 35 53423 52946 29846074
Ascites 24.57 11.12 17 53441 35904 29863116
Hyperexplexia 24.51 11.12 7 53451 37 29898983
Rash morbilliform 24.28 11.12 26 53432 2476 29896544
Clumsiness 24.26 11.12 20 53438 1367 29897653
Epileptic psychosis 24.22 11.12 6 53452 16 29899004
Guillain-Barre syndrome 24.09 11.12 37 53421 5046 29893974
Pain in extremity 24.03 11.12 108 53350 110113 29788907
Asterixis 23.81 11.12 19 53439 1240 29897780
Mood altered 23.46 11.12 48 53410 8202 29890818
Neutropenia 23.45 11.12 134 53324 128406 29770614
Diabetic neuropathy 23.41 11.12 32 53426 3927 29895093
Gingival atrophy 23.22 11.12 7 53451 46 29898974
Hyperammonaemic encephalopathy 23.09 11.12 22 53436 1822 29897198
Decreased appetite 22.90 11.12 165 53293 149745 29749275
Sinus arrest 22.67 11.12 20 53438 1500 29897520
Apgar score low 22.63 11.12 16 53442 869 29898151
Infection 22.61 11.12 68 53390 78006 29821014
Pyrexia 22.55 11.12 686 52772 293803 29605217
Hyperkinesia 22.50 11.12 23 53435 2075 29896945
Delusion 22.25 11.12 59 53399 11930 29887090
Loose associations 22.14 11.12 7 53451 55 29898965
Skin erosion 22.11 11.12 21 53437 1732 29897288
Abdominal discomfort 22.09 11.12 33 53425 48758 29850262
Drowning 22.06 11.12 12 53446 407 29898613
Congenital cystic lung 22.05 11.12 10 53448 227 29898793
Microcephaly 21.99 11.12 14 53444 638 29898382
Bone marrow failure 21.87 11.12 13 53445 29772 29869248
COVID-19 21.82 11.12 3 53455 17875 29881145
Thrombosis 21.72 11.12 26 53432 42205 29856815
Atonic seizures 21.71 11.12 9 53449 163 29898857
Wrong patient received product 21.48 11.12 21 53437 1796 29897224
Gaze palsy 21.34 11.12 17 53441 1107 29897913
Epidermal necrosis 21.33 11.12 12 53446 435 29898585
Papule 21.11 11.12 27 53431 3106 29895914
Drug level below therapeutic 20.94 11.12 28 53430 3364 29895656
Personality disorder 20.93 11.12 17 53441 1138 29897882
Infusion related reaction 20.84 11.12 25 53433 40539 29858481
Osteonecrosis of jaw 20.77 11.12 4 53454 18614 29880406
Pleural effusion 20.39 11.12 66 53392 74000 29825020
Micrognathia 20.30 11.12 10 53448 275 29898745
Trismus 20.22 11.12 23 53435 2342 29896678
Hyperkalaemia 20.20 11.12 56 53402 65954 29833066
Accidental overdose 20.08 11.12 75 53383 18200 29880820
Water intoxication 20.03 11.12 12 53446 490 29898530
Brain malformation 19.97 11.12 7 53451 78 29898942
Hangover 19.82 11.12 16 53442 1062 29897958
Condition aggravated 19.49 11.12 350 53108 137516 29761504
Genital erosion 19.47 11.12 9 53449 214 29898806
Middle insomnia 19.35 11.12 36 53422 5737 29893283
Intentional product use issue 19.21 11.12 22 53436 36418 29862602
Hepatosplenomegaly 19.05 11.12 28 53430 3673 29895347
Congenital anomaly 18.93 11.12 17 53441 1305 29897715
Neonatal pneumonia 18.93 11.12 7 53451 92 29898928
Myocardial strain 18.93 11.12 7 53451 92 29898928
Cerebellar ataxia 18.93 11.12 15 53443 969 29898051
Anger 18.92 11.12 53 53405 11067 29887953
Angina pectoris 18.85 11.12 15 53443 29503 29869517
Drug ineffective 18.62 11.12 763 52695 339624 29559396
Rash papular 18.61 11.12 45 53413 8600 29890420
Abdominal pain upper 18.45 11.12 54 53404 62497 29836523
Suicidal ideation 18.45 11.12 119 53339 35995 29863025
Rebound effect 18.37 11.12 18 53440 1543 29897477
Full blood count decreased 18.35 11.12 3 53455 15714 29883306
Constipation 18.35 11.12 122 53336 112784 29786236
Completed suicide 18.34 11.12 264 53194 99228 29799792
Lymphocytosis 18.29 11.12 20 53438 1950 29897070
Haemorrhage 18.23 11.12 34 53424 46045 29852975
Oculomucocutaneous syndrome 18.13 11.12 8 53450 170 29898850
Perseveration 18.09 11.12 7 53451 105 29898915
Unevaluable event 18.08 11.12 18 53440 31767 29867253
Bone metabolism disorder 17.89 11.12 9 53449 259 29898761
Blood pressure increased 17.84 11.12 67 53391 71861 29827159
Affect lability 17.80 11.12 26 53432 3392 29895628
Pneumonia aspiration 17.80 11.12 122 53336 37658 29861362
General physical health deterioration 17.78 11.12 105 53353 99839 29799181
Melaena 17.74 11.12 19 53439 32418 29866602
Chronic kidney disease 17.71 11.12 25 53433 37813 29861207
Phalangeal hypoplasia 17.67 11.12 4 53454 6 29899014
Fluid overload 17.66 11.12 6 53452 19086 29879934
Bradyphrenia 17.64 11.12 28 53430 3929 29895091
Hypomagnesaemia 17.62 11.12 4 53454 16594 29882426
Antisocial behaviour 17.49 11.12 9 53449 272 29898748
Arthritis 17.42 11.12 11 53447 24390 29874630
Neonatal hypotension 17.40 11.12 7 53451 117 29898903
Lactic acidosis 17.39 11.12 18 53440 31195 29867825
Haemoglobin decreased 17.21 11.12 126 53332 113972 29785048
Onychophagia 17.12 11.12 5 53453 29 29898991
Personality change 17.09 11.12 30 53428 4570 29894450
Cardiac disorder 17.09 11.12 28 53430 39865 29859155
Developmental delay 16.93 11.12 20 53438 2121 29896899
Strabismus 16.87 11.12 15 53443 1137 29897883
Gout 16.80 11.12 5 53453 17310 29881710
Presyncope 16.79 11.12 4 53454 16052 29882968
Ultrasound liver abnormal 16.78 11.12 7 53451 129 29898891
Therapeutic response unexpected 16.71 11.12 44 53414 8859 29890161
Sinusitis 16.65 11.12 21 53437 33324 29865696
Withdrawal syndrome 16.63 11.12 51 53407 11199 29887821
Osteoarthritis 16.57 11.12 6 53452 18343 29880677
Blister 16.54 11.12 77 53381 20606 29878414
Blood sodium decreased 16.54 11.12 64 53394 15792 29883228
Mouth ulceration 16.53 11.12 49 53409 10560 29888460
Temporal lobe epilepsy 16.48 11.12 7 53451 135 29898885
Arachnoid cyst 16.44 11.12 8 53450 214 29898806
Tracheo-oesophageal fistula 16.42 11.12 10 53448 421 29898599
Bone density decreased 16.42 11.12 18 53440 1760 29897260
Muscle spasms 16.34 11.12 60 53398 64778 29834242
Hypertrophic scar 16.33 11.12 4 53454 10 29899010
Distractibility 16.26 11.12 9 53449 316 29898704
Pneumonitis 16.25 11.12 15 53443 27439 29871581
Pressure of speech 16.19 11.12 10 53448 432 29898588
Hypertension 16.00 11.12 139 53319 121215 29777805
Atypical benign partial epilepsy 15.99 11.12 3 53455 0 29899020
Eyelid myoclonus 15.99 11.12 3 53455 0 29899020
Human herpesvirus 7 infection 15.99 11.12 3 53455 0 29899020
Salivary hypersecretion 15.87 11.12 39 53419 7527 29891493
Prominent epicanthal folds 15.85 11.12 7 53451 149 29898871
Osteomalacia 15.69 11.12 13 53445 895 29898125
Potentiating drug interaction 15.67 11.12 29 53429 4602 29894418
Contraindicated product prescribed 15.66 11.12 9 53449 340 29898680
Cerebral palsy 15.63 11.12 6 53452 88 29898932
Fluid retention 15.59 11.12 13 53445 24985 29874035
Learning disability 15.56 11.12 7 53451 156 29898864
Influenza 15.48 11.12 34 53424 43364 29855656
Ventricular tachycardia 15.40 11.12 12 53446 23850 29875170
Xanthoma 15.39 11.12 6 53452 92 29898928
Dysgeusia 15.35 11.12 13 53445 24788 29874232
Salivary gland calculus 15.32 11.12 5 53453 44 29898976
Body height below normal 15.30 11.12 8 53450 250 29898770
Abulia 15.24 11.12 10 53448 480 29898540
Thinking abnormal 15.22 11.12 31 53427 5280 29893740
Xanthelasma 15.21 11.12 6 53452 95 29898925
Psychiatric symptom 15.18 11.12 24 53434 3355 29895665
Cholinergic syndrome 15.06 11.12 10 53448 490 29898530
Dysphagia 14.99 11.12 161 53297 56537 29842483
Contraindicated product administered 14.95 11.12 6 53452 17225 29881795
Labelled drug-food interaction medication error 14.93 11.12 5 53453 48 29898972
Communication disorder 14.89 11.12 19 53439 2181 29896839
Drug level above therapeutic 14.79 11.12 22 53436 2917 29896103
Peritonitis 14.77 11.12 10 53448 21365 29877655
Maternal drugs affecting foetus 14.76 11.12 27 53431 4246 29894774
Suspiciousness 14.75 11.12 9 53449 380 29898640
Euphoric mood 14.69 11.12 27 53431 4263 29894757
Rickets 14.58 11.12 5 53453 52 29898968
Mycoplasma infection 14.50 11.12 8 53450 279 29898741
Pericardial effusion 14.46 11.12 10 53448 21134 29877886
Carnitine deficiency 14.41 11.12 5 53453 54 29898966
Measles 14.31 11.12 6 53452 112 29898908
Dystonia 14.29 11.12 44 53414 9683 29889337
Trigemino-cardiac reflex 14.21 11.12 6 53452 114 29898906
Rash pustular 14.18 11.12 29 53429 4954 29894066
Skin ulcer 14.16 11.12 8 53450 18841 29880179
Congenital eye disorder 14.09 11.12 5 53453 58 29898962
Haemoptysis 14.08 11.12 21 53437 31057 29867963
Depressed mood 14.06 11.12 64 53394 16965 29882055
Feelings of worthlessness 14.03 11.12 7 53451 198 29898822
Low set ears 14.02 11.12 9 53449 416 29898604
Poriomania 14.02 11.12 6 53452 118 29898902
Tonic clonic movements 14.01 11.12 13 53445 1041 29897979
Muscle twitching 14.00 11.12 39 53419 8116 29890904
Hyporeflexia 14 11.12 17 53441 1855 29897165
Premature baby 13.99 11.12 63 53395 16628 29882392
Arthropathy 13.92 11.12 10 53448 20717 29878303
Biopsy lymph gland abnormal 13.92 11.12 3 53455 3 29899017
Fibromatosis 13.92 11.12 3 53455 3 29899017
Kluver-Bucy syndrome 13.92 11.12 3 53455 3 29899017
Seizure cluster 13.88 11.12 6 53452 121 29898899
Coma scale abnormal 13.84 11.12 23 53435 3353 29895667
Torticollis 13.79 11.12 13 53445 1062 29897958
Gastric hypomotility 13.79 11.12 5 53453 62 29898958
Septic encephalopathy 13.79 11.12 5 53453 62 29898958
Emotional disorder 13.73 11.12 29 53429 5065 29893955
Clostridium difficile colitis 13.71 11.12 3 53455 12765 29886255
Diverticulitis 13.69 11.12 7 53451 17438 29881582
Bronchitis 13.67 11.12 31 53427 39094 29859926
Rectal haemorrhage 13.63 11.12 26 53432 34913 29864107
Therapy cessation 13.59 11.12 5 53453 15132 29883888
Nervousness 13.47 11.12 49 53409 11739 29887281
Stomatitis 13.47 11.12 29 53429 37250 29861770
Rash erythematous 13.38 11.12 77 53381 22375 29876645
Stupor 13.30 11.12 21 53437 2932 29896088
Brugada syndrome 13.30 11.12 10 53448 598 29898422
Feeling of despair 13.29 11.12 12 53446 928 29898092
Localised infection 13.27 11.12 4 53454 13733 29885287
Renal impairment 13.15 11.12 92 53366 84092 29814928
Hypogammaglobulinaemia 13.13 11.12 29 53429 5223 29893797
Regressive behaviour 13.05 11.12 4 53454 28 29898992
Open angle glaucoma 13.04 11.12 7 53451 231 29898789
Memory impairment 13.01 11.12 112 53346 37062 29861958
Haematuria 13.01 11.12 39 53419 44795 29854225
Neonatal cholestasis 12.93 11.12 4 53454 29 29898991
Pigmentation disorder 12.93 11.12 17 53441 2009 29897011
Hypochloraemia 12.91 11.12 10 53448 625 29898395
Chapped lips 12.89 11.12 9 53449 479 29898541
Hyperdynamic left ventricle 12.86 11.12 5 53453 76 29898944
Multiple drug therapy 12.80 11.12 7 53451 240 29898780
Blood creatinine increased 12.79 11.12 103 53355 91272 29807748
Attention deficit hyperactivity disorder 12.73 11.12 16 53442 1808 29897212
Tremor 12.72 11.12 197 53261 75166 29823854
Blood cholesterol increased 12.71 11.12 62 53396 16908 29882112
Delusion of grandeur 12.66 11.12 8 53450 360 29898660
Myoclonic epilepsy 12.58 11.12 11 53447 815 29898205
Blood urea decreased 12.58 11.12 12 53446 995 29898025
Asthenia 12.54 11.12 300 53158 220990 29678030
Multiple congenital abnormalities 12.52 11.12 9 53449 502 29898518
Affective disorder 12.51 11.12 21 53437 3087 29895933
Maternal exposure during breast feeding 12.50 11.12 15 53443 1617 29897403
Gingival hypertrophy 12.49 11.12 15 53443 1618 29897402
Ammonia increased 12.44 11.12 25 53433 4216 29894804
Chills 12.34 11.12 77 53381 72261 29826759
Subacute cutaneous lupus erythematosus 12.32 11.12 10 53448 669 29898351
Injection site pain 12.31 11.12 22 53436 30288 29868732
Conjunctival disorder 12.25 11.12 5 53453 87 29898933
Hypercapnic coma 12.24 11.12 6 53452 163 29898857
C-reactive protein increased 12.22 11.12 125 53333 43348 29855672
Cryptorchism 12.17 11.12 15 53443 1662 29897358
Renal injury 12.11 11.12 3 53455 11726 29887294
Ischaemic gastritis 12.11 11.12 3 53455 8 29899012
Nephrolithiasis 12 11.12 16 53442 24794 29874226
Enanthema 11.99 11.12 8 53450 395 29898625
Stab wound 11.95 11.12 6 53452 172 29898848
Congenital arterial malformation 11.94 11.12 5 53453 93 29898927
Testicular retraction 11.85 11.12 3 53455 9 29899011
Univentricular heart 11.85 11.12 3 53455 9 29899011
Rhesus incompatibility 11.85 11.12 3 53455 9 29899011
Drug half-life reduced 11.85 11.12 3 53455 9 29899011
Flatulence 11.85 11.12 9 53449 18120 29880900
Drug withdrawal syndrome 11.84 11.12 68 53390 19741 29879279
Gingival disorder 11.75 11.12 13 53445 1284 29897736
Lennox-Gastaut syndrome 11.71 11.12 4 53454 41 29898979
Schizophreniform disorder 11.71 11.12 4 53454 41 29898979
Abdominal distension 11.71 11.12 42 53416 45667 29853353
Psychomotor skills impaired 11.71 11.12 16 53442 1963 29897057
Cataract 11.71 11.12 13 53445 21822 29877198
Cough 11.68 11.12 156 53302 125486 29773534
Palmar-plantar erythrodysaesthesia syndrome 11.62 11.12 6 53452 14864 29884156
Tardive dyskinesia 11.62 11.12 27 53431 5030 29893990
Hyperbilirubinaemia 11.61 11.12 8 53450 16934 29882086
Peritonitis bacterial 11.57 11.12 3 53455 11375 29887645
Hyperthermia 11.56 11.12 42 53416 10057 29888963
Glomerular filtration rate decreased 11.55 11.12 3 53455 11359 29887661
Cluster headache 11.47 11.12 9 53449 573 29898447
Epidermolysis bullosa 11.38 11.12 5 53453 105 29898915
Binocular eye movement disorder 11.38 11.12 4 53454 45 29898975
Inhibitory drug interaction 11.34 11.12 14 53444 1554 29897466
Brain oedema 11.30 11.12 48 53410 12350 29886670
Dependent personality disorder 11.30 11.12 4 53454 46 29898974
Ligament sprain 11.28 11.12 19 53439 2801 29896219
Blood osmolarity decreased 11.26 11.12 9 53449 589 29898431
Restlessness 11.25 11.12 74 53384 22525 29876495
Staphylococcal impetigo 11.18 11.12 3 53455 12 29899008
Trigeminal nerve disorder 11.18 11.12 3 53455 12 29899008
Drug withdrawal convulsions 11.17 11.12 12 53446 1147 29897873
Hyperpyrexia 11.16 11.12 18 53440 2559 29896461
Hyperacusis 11.15 11.12 9 53449 597 29898423
Bacteraemia 11.13 11.12 7 53451 15553 29883467

Pharmacologic Action:

SourceCodeDescription
ATC N03AF01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Carboxamide derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC N0000175751 Mood Stabilizer
CHEBI has role CHEBI:35477 antimanics
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38633 sodium channel blockers
CHEBI has role CHEBI:52290 mitogens
CHEBI has role CHEBI:61115 hdac inhibitor
CHEBI has role CHEBI:64370 excitatory amino-acid transporter activator
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D065701 Cytochrome P-450 CYP3A Inducers
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014149 Tranquilizing Agents
FDA MoA N0000185506 Cytochrome P450 3A4 Inducers
FDA MoA N0000185507 Cytochrome P450 2C9 Inducers
FDA MoA N0000185607 Cytochrome P450 2C19 Inducers
FDA MoA N0000187064 Cytochrome P450 2B6 Inducers
FDA MoA N0000191266 Cytochrome P450 1A2 Inducers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Trigeminal neuralgia indication 31681005 DOID:12098
Glossopharyngeal neuralgia indication 43763009 DOID:14423
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Localization-related epilepsy indication 230381009 DOID:2234
Lennox-Gastaut syndrome indication 230418006
Tonic-clonic epilepsy indication 352818000 DOID:7725
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Mixed Epilepsy indication
Neurohypophyseal diabetes insipidus off-label use 45369008 DOID:12388
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Attention deficit hyperactivity disorder off-label use 406506008
Prevention of Seizures following Cranial Trauma or Surgery off-label use
Rapid Cycling Bipolar Affective Disorder off-label use
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Hypercholesterolemia contraindication 13644009
Agranulocytosis contraindication 17182001 DOID:12987
Mood swings contraindication 18963009
Glaucoma contraindication 23986001 DOID:1686
Complete atrioventricular block contraindication 27885002
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Absence seizure contraindication 79631006
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Impaired renal function disorder contraindication 197663003
Non-infective meningitis contraindication 230155003
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Bone marrow depression contraindication 307762000
Disorder of coronary artery contraindication 414024009
HLA-B 1502 Positive Status contraindication
Carbamazepine Toxicity contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.13 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
200MG/20ML (10MG/ML) CARNEXIV LUNDBECK PHARMS LLC N206030 Oct. 7, 2016 DISCN SOLUTION INTRAVENOUS Oct. 7, 2023 REPLACEMENT THERAPY FOR ORAL CARBAMAZEPINE FORMULATIONS, WHEN ORAL ADMINISTRATION IS TEMPORARILY NOT FEASIBLE, IN ADULTS WITH THE FOLLOWING SEIZURE TYPES: PARTIAL WITH COMPLEX SYMPTOMOLOGY, GENERALIZED CLONIC-TONIC, AND MIXED

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.66 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.28 CHEMBL CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Histamine H1 receptor GPCR Ki 4.13 WOMBAT-PK
Neuronal acetylcholine receptor; alpha2/beta4 Ion channel IC50 4.31 WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Kd 4.49 WOMBAT-PK
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel WOMBAT-PK

External reference:

IDSource
4017873 VUID
N0000146226 NUI
D00252 KEGG_DRUG
85756-57-6 SECONDARY_CAS_RN
4017873 VANDF
C0006949 UMLSCUI
CHEBI:3387 CHEBI
N6W PDB_CHEM_ID
CHEMBL108 ChEMBL_ID
DB00564 DRUGBANK_ID
D002220 MESH_DESCRIPTOR_UI
1836 INN_ID
2554 PUBCHEM_CID
5339 IUPHAR_LIGAND_ID
33CM23913M UNII
2002 RXNORM
4350 MMSL
513 MMSL
d00058 MMSL
001634 NDDF
387222003 SNOMEDCT_US
40820003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0508 SUSPENSION 100 mg ORAL NDA 27 sections
Tegretol HUMAN PRESCRIPTION DRUG LABEL 1 0078-0509 TABLET 200 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0510 TABLET, EXTENDED RELEASE 100 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0511 TABLET, EXTENDED RELEASE 200 mg ORAL NDA 27 sections
TegretolXR HUMAN PRESCRIPTION DRUG LABEL 1 0078-0512 TABLET, EXTENDED RELEASE 400 mg ORAL NDA 27 sections
Epitol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0090 TABLET 200 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0109 TABLET 200 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0093-0778 TABLET, CHEWABLE 100 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-0862 SUSPENSION 100 mg ORAL ANDA 28 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0121-1724 SUSPENSION 200 mg ORAL ANDA 28 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0615-3505 TABLET 200 mg ORAL ANDA 21 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 0615-4515 TABLET 100 mg ORAL ANDA 25 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8125 TABLET, CHEWABLE 100 mg ORAL ANDA 29 sections
CarbamazepineER HUMAN PRESCRIPTION DRUG LABEL 1 0781-5987 TABLET, EXTENDED RELEASE 200 mg ORAL NDA authorized generic 27 sections
CarbamazepineER HUMAN PRESCRIPTION DRUG LABEL 1 0781-5988 TABLET, EXTENDED RELEASE 400 mg ORAL NDA authorized generic 27 sections
CarbamazepineER HUMAN PRESCRIPTION DRUG LABEL 1 0781-8016 TABLET, EXTENDED RELEASE 100 mg ORAL NDA authorized generic 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6022 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 27 sections
Carbamazepin HUMAN PRESCRIPTION DRUG LABEL 1 0832-6023 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 27 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0832-6024 TABLET, EXTENDED RELEASE 400 mg ORAL ANDA 27 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-3854 TABLET, CHEWABLE 100 mg ORAL ANDA 23 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 0904-6172 TABLET 200 mg ORAL ANDA 23 sections
Carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 0904-6885 CAPSULE, EXTENDED RELEASE 200 mg ORAL ANDA 25 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 13668-268 TABLET 200 mg ORAL ANDA 23 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 13668-271 TABLET, CHEWABLE 100 mg ORAL ANDA 23 sections
CARBAMAZEPINE Human Prescription Drug Label 1 16571-680 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 25 sections
CARBAMAZEPINE Human Prescription Drug Label 1 16571-681 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 25 sections
CARBAMAZEPINE Human Prescription Drug Label 1 16571-682 TABLET, EXTENDED RELEASE 400 mg ORAL ANDA 25 sections
CARBAMAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-475 TABLET 200 mg ORAL ANDA 27 sections
carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 16714-063 TABLET, EXTENDED RELEASE 100 mg ORAL ANDA 24 sections
carbamazepine HUMAN PRESCRIPTION DRUG LABEL 1 16714-064 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 24 sections