Stem definition | Drug id | CAS RN |
---|---|---|
antivirals | 4887 | 259793-96-9 |
Dose | Unit | Route |
---|---|---|
1.60 | g | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
March 24, 2014 | PMDA | Toyama Chemical Co., Ltd. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 357.15 | 120.47 | 127 | 228 | 556053 | 55735659 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 841.34 | 88.03 | 304 | 507 | 346970 | 31349563 |
Intentional product use issue | 93.48 | 88.03 | 38 | 773 | 49309 | 31647224 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 1169.85 | 86.68 | 431 | 815 | 742629 | 70184569 |
COVID-19 | 144.72 | 86.68 | 58 | 1188 | 105699 | 70821499 |
COVID-19 pneumonia | 101.34 | 86.68 | 30 | 1216 | 21939 | 70905259 |
None
Source | Code | Description |
---|---|---|
ATC | J05AX27 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Other antivirals |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000998 | Antiviral Agents |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
CHEBI has role | CHEBI:170010 | EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Influenza | indication | 6142004 | DOID:8469 |
Influenza caused by pandemic influenza virus | indication | 719865001 | |
Coronavirus infection | off-label use | 186747009 | |
Pregnancy, function | contraindication | 289908002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.57 | acidic |
pKa2 | 11.39 | acidic |
pKa3 | 1.24 | Basic |
None
None
None
ID | Source |
---|---|
EW5GL2X7E0 | UNII |
D09537 | KEGG_DRUG |
C1138226 | UMLSCUI |
CHEBI:134722 | CHEBI |
CHEMBL221722 | ChEMBL_ID |
492405 | PUBCHEM_CID |
DB12466 | DRUGBANK_ID |
8916 | INN_ID |
C462182 | MESH_SUPPLEMENTAL_RECORD_UI |
11139 | IUPHAR_LIGAND_ID |
018626 | NDDF |
1163580005 | SNOMEDCT_US |
1172871009 | SNOMEDCT_US |
None