dulaglutide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
glucagon-like peptide (GLP) analogues and agonists 4885 923950-08-7

Description:

MoleculeDescription

Synonyms:

  • dulaglutide
  • trulicity
  • LY2189265
a glucagon-like peptide-1 receptor agonist; GLP-1 immunoglobulin G (IgG4) Fc fusion protein with extended activity
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.16 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 22, 2014 EMA
Sept. 18, 2014 FDA ELI LILLY AND CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 556.07 18.05 294 12963 83462 63392303
Nausea 497.46 18.05 736 12521 853735 62622030
Injection site pain 448.75 18.05 299 12958 129501 63346264
Accidental underdose 413.83 18.05 80 13177 723 63475042
Glycosylated haemoglobin increased 305.45 18.05 110 13147 12288 63463477
Extra dose administered 249.55 18.05 80 13177 6270 63469495
Diabetic ketoacidosis 226.05 18.05 102 13155 20403 63455362
Incorrect dose administered 213.55 18.05 141 13116 59827 63415938
Vomiting 181.66 18.05 375 12882 559242 62916523
Pancreatitis 159.37 18.05 109 13148 48946 63426819
Inappropriate schedule of product administration 158.40 18.05 148 13109 103817 63371948
Accidental overdose 143.46 18.05 78 13179 23231 63452534
Injection site pruritus 141.24 18.05 98 13159 45018 63430747
Injection site haemorrhage 140.37 18.05 78 13179 24236 63451529
Product dose omission issue 131.39 18.05 200 13057 234113 63241652
Injection site erythema 125.85 18.05 118 13139 83056 63392709
Product administered at inappropriate site 120.94 18.05 39 13218 3110 63472655
Injury associated with device 107.31 18.05 37 13220 3629 63472136
Diabetic metabolic decompensation 103.32 18.05 30 13227 1680 63474085
Abdominal pain upper 100.14 18.05 165 13092 206279 63269486
Hypoglycaemia 98.16 18.05 89 13168 59976 63415789
Injection site mass 91.97 18.05 54 13203 18602 63457163
Injection site bruising 80.31 18.05 68 13189 41842 63433923
Blood glucose abnormal 79.82 18.05 37 13220 7855 63467910
Euglycaemic diabetic ketoacidosis 77.14 18.05 29 13228 3645 63472120
Acute kidney injury 72.83 18.05 166 13091 263249 63212516
Diarrhoea 67.44 18.05 311 12946 715055 62760710
Blood glucose decreased 66.67 18.05 46 13211 20906 63454859
Injection site rash 66.30 18.05 44 13213 18765 63457000
Underdose 61.94 18.05 49 13208 27407 63448358
Diabetes mellitus inadequate control 57.25 18.05 37 13220 15089 63460676
Lactic acidosis 57.23 18.05 54 13203 38233 63437532
Injection site urticaria 52.22 18.05 34 13223 14039 63461726
Pancreatic carcinoma 51.04 18.05 27 13230 7601 63468164
Transcription medication error 49.21 18.05 11 13246 211 63475554
Eructation 48.80 18.05 27 13230 8306 63467459
Weight decreased 42.81 18.05 141 13116 276657 63199108
Ketoacidosis 42.64 18.05 20 13237 4358 63471407
Pancreatitis acute 41.90 18.05 39 13218 27127 63448638
Wrong technique in product usage process 41.76 18.05 58 13199 62282 63413483
Systemic infection 38.45 18.05 19 13238 4641 63471124
Injection site swelling 36.04 18.05 47 13210 47525 63428240
Impaired gastric emptying 36.00 18.05 24 13233 10308 63465457
Blood glucose fluctuation 35.81 18.05 18 13239 4558 63471207
Arthropathy 35.08 18.05 4 13253 234788 63240977
Lichen planus 33.48 18.05 14 13243 2324 63473441
Dehydration 32.99 18.05 95 13162 173259 63302506
Hyperglycaemic hyperosmolar nonketotic syndrome 32.94 18.05 11 13246 978 63474787
Injection site injury 32.90 18.05 10 13247 656 63475109
Toxicity to various agents 32.79 18.05 6 13251 247244 63228521
Systemic lupus erythematosus 32.66 18.05 3 13254 208915 63266850
COVID-19 31.96 18.05 72 13185 113031 63362734
Thirst decreased 31.30 18.05 8 13249 276 63475489
Accidental exposure to product 28.83 18.05 32 13225 27373 63448392
Treatment failure 28.25 18.05 4 13253 199039 63276726
Blood calcitonin increased 27.94 18.05 5 13252 28 63475737
Lipase increased 27.47 18.05 20 13237 9880 63465885
Hyperglycaemia 26.61 18.05 38 13219 41829 63433936
Joint swelling 25.17 18.05 19 13238 327647 63148118
Infusion related reaction 24.99 18.05 10 13247 245511 63230254
Coronavirus test positive 23.68 18.05 8 13249 737 63475028
Vomiting projectile 22.35 18.05 9 13248 1357 63474408
Diabetic ketosis 21.93 18.05 6 13251 270 63475495
Decreased appetite 21.88 18.05 107 13150 250945 63224820
Therapeutic product effect decreased 21.12 18.05 7 13250 193180 63282585
Exposure during pregnancy 20.13 18.05 4 13253 155543 63320222
Stomatitis 19.19 18.05 3 13254 138722 63337043
Product prescribing error 18.41 18.05 25 13232 26264 63449501
Injection site irritation 18.40 18.05 12 13245 4966 63470799
Illness 18.27 18.05 35 13222 49024 63426741
Glomerular filtration rate decreased 18.27 18.05 18 13239 13423 63462342
Pneumonia 18.23 18.05 43 13214 456724 63019041

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 416.33 19.77 256 10356 66462 34879857
Accidental underdose 333.48 19.77 66 10546 448 34945871
Injection site pain 331.27 19.77 183 10429 38822 34907497
Glycosylated haemoglobin increased 254.20 19.77 104 10508 11256 34935063
Pancreatitis 231.32 19.77 145 10467 38746 34907573
Extra dose administered 223.23 19.77 72 10540 3937 34942382
Nausea 216.94 19.77 376 10236 339532 34606787
Inappropriate schedule of product administration 212.34 19.77 165 10447 62131 34884188
Diabetic ketoacidosis 193.50 19.77 99 10513 17933 34928386
Diabetes mellitus inadequate control 141.74 19.77 73 10539 13391 34932928
Incorrect dose administered 139.37 19.77 108 10504 40407 34905912
Diarrhoea 133.07 19.77 334 10278 389578 34556741
Pancreatitis acute 119.11 19.77 85 10527 28056 34918263
Vomiting 113.90 19.77 239 10373 247382 34698937
Injection site mass 106.38 19.77 48 10564 6578 34939741
Injection site haemorrhage 100.02 19.77 52 10560 9716 34936603
Injection site erythema 98.72 19.77 61 10551 15838 34930481
Accidental overdose 97.30 19.77 66 10546 20074 34926245
Euglycaemic diabetic ketoacidosis 94.84 19.77 36 10576 3186 34943133
Injection site pruritus 88.62 19.77 43 10569 6940 34939379
Product dose omission issue 82.97 19.77 138 10474 119573 34826746
Ketoacidosis 78.63 19.77 34 10578 4209 34942110
Metabolic acidosis 71.90 19.77 77 10535 43603 34902716
Underdose 63.80 19.77 44 10568 13736 34932583
Hyperglycaemia 62.17 19.77 68 10544 39412 34906907
Obstructive pancreatitis 60.20 19.77 17 10595 587 34945732
Weight decreased 58.55 19.77 150 10462 176151 34770168
Glycosylated haemoglobin abnormal 58.05 19.77 13 10599 169 34946150
Hyperlipasaemia 53.86 19.77 15 10597 492 34945827
Lactic acidosis 51.48 19.77 58 10554 34714 34911605
Injection site swelling 51.46 19.77 36 10576 11491 34934828
Eructation 50.76 19.77 26 10586 4705 34941614
Blood glucose abnormal 50.58 19.77 28 10584 5924 34940395
Lipase increased 48.19 19.77 32 10580 9384 34936935
Pancreatic carcinoma 47.38 19.77 31 10581 8870 34937449
Hypoglycaemia 44.65 19.77 68 10544 54572 34891747
Toxicity to various agents 43.48 19.77 5 10607 200357 34745962
Injection site rash 42.19 19.77 22 10590 4131 34942188
Injection site bruising 40.89 19.77 28 10584 8635 34937684
Injury associated with device 38.36 19.77 14 10598 1109 34945210
Product storage error 37.74 19.77 26 10586 8096 34938223
Abdominal discomfort 37.43 19.77 66 10546 59769 34886550
Injection site discomfort 36.86 19.77 15 10597 1595 34944724
Gastrointestinal disorder 34.69 19.77 47 10565 33901 34912418
Blood glucose decreased 34.36 19.77 30 10582 13207 34933112
Pancreatic carcinoma metastatic 34.00 19.77 17 10595 2923 34943396
Injection site reaction 32.75 19.77 29 10583 13004 34933315
Abdominal pain 30.58 19.77 114 10498 163504 34782815
Injection site urticaria 30.08 19.77 14 10598 2058 34944261
Hyperkinetic heart syndrome 29.40 19.77 7 10605 121 34946198
Dyspepsia 28.99 19.77 45 10567 36687 34909632
Wrong drug 26.72 19.77 6 10606 79 34946240
Ketonuria 26.13 19.77 9 10603 602 34945717
Pneumonia 25.03 19.77 45 10567 362582 34583737
Acute kidney injury 24.96 19.77 168 10444 304820 34641499
Gastric dilatation 24.50 19.77 9 10603 726 34945593
Febrile neutropenia 23.99 19.77 6 10606 136843 34809476
Injection site nodule 23.28 19.77 11 10601 1672 34944647
Pyrexia 23.26 19.77 41 10571 332972 34613347
Decreased appetite 23.23 19.77 106 10506 166286 34780033
Product monitoring error 22.68 19.77 15 10597 4366 34941953
Flatulence 22.64 19.77 30 10582 21168 34925151
Impaired gastric emptying 20.79 19.77 13 10599 3440 34942879
Pulmonary oedema 20.66 19.77 45 10567 47484 34898835
Disease progression 20.43 19.77 4 10608 108073 34838246

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood glucose increased 414.52 15.53 268 15713 114707 79613700
Diabetic ketoacidosis 352 15.53 160 15821 33962 79694445
Pancreatitis 249.63 15.53 161 15820 68414 79659993
Glycosylated haemoglobin increased 242.73 15.53 104 15877 19156 79709251
Injection site pain 210.63 15.53 188 15793 129650 79598757
Nausea 189.77 15.53 516 15465 956680 78771727
Vomiting 189.54 15.53 413 15568 665415 79062992
Euglycaemic diabetic ketoacidosis 183.44 15.53 64 15917 6780 79721627
Pancreatitis acute 176.84 15.53 115 15866 49489 79678918
Diabetes mellitus inadequate control 166.13 15.53 86 15895 24178 79704229
Accidental underdose 145.81 15.53 34 15947 828 79727579
Acute kidney injury 131.54 15.53 308 15673 519096 79209311
Lactic acidosis 126.26 15.53 108 15873 70251 79658156
Diarrhoea 122.56 15.53 420 15561 880069 78848338
Extra dose administered 117.85 15.53 49 15932 8366 79720041
Hypoglycaemia 103.02 15.53 114 15867 101480 79626927
Hyperglycaemia 102.48 15.53 96 15885 70239 79658168
Ketoacidosis 100.86 15.53 43 15938 7811 79720596
Product dose omission issue 91.94 15.53 172 15809 247365 79481042
Pancreatic carcinoma 86.85 15.53 46 15935 13531 79714876
Metabolic acidosis 86.06 15.53 94 15887 82435 79645972
Inappropriate schedule of product administration 84.04 15.53 118 15863 133510 79594897
Diabetic metabolic decompensation 81.06 15.53 29 15952 3303 79725104
Incorrect dose administered 79.41 15.53 87 15894 76543 79651864
Accidental overdose 73.51 15.53 62 15919 39519 79688888
Injury associated with device 68.61 15.53 26 15955 3480 79724927
Injection site pruritus 67.97 15.53 61 15920 42222 79686185
Lipase increased 63.14 15.53 40 15941 16426 79711981
Injection site erythema 61.37 15.53 77 15904 78120 79650287
Obstructive pancreatitis 60.66 15.53 17 15964 873 79727534
Injection site haemorrhage 56.63 15.53 46 15935 27824 79700583
Weight decreased 55.77 15.53 177 15804 355021 79373386
Toxicity to various agents 55.50 15.53 9 15972 421531 79306876
Pancreatic carcinoma metastatic 49.68 15.53 21 15960 3732 79724675
Eructation 48.18 15.53 29 15952 10880 79717527
Hyperlipasaemia 46.60 15.53 15 15966 1239 79727168
Blood glucose decreased 46.47 15.53 40 15941 26194 79702213
Blood glucose abnormal 46.43 15.53 28 15953 10538 79717869
Transcription medication error 41.96 15.53 11 15970 438 79727969
Wrong technique in product usage process 40.24 15.53 61 15920 73814 79654593
Injection site rash 39.38 15.53 31 15950 17923 79710484
Product administered at inappropriate site 38.97 15.53 18 15963 3947 79724460
Underdose 38.49 15.53 40 15941 33111 79695296
Injection site mass 38.25 15.53 32 15949 20152 79708255
Blood glucose fluctuation 35.43 15.53 20 15961 6662 79721745
Ketonuria 35.09 15.53 12 15969 1196 79727211
COVID-19 33.83 15.53 88 15893 157586 79570821
Product prescribing error 33.36 15.53 43 15938 44770 79683637
Dehydration 32.96 15.53 117 15864 248070 79480337
Hyperkinetic heart syndrome 31.77 15.53 7 15974 131 79728276
Lichen planus 31.65 15.53 14 15967 2777 79725630
Decreased appetite 30.79 15.53 143 15838 342275 79386132
Injection site bruising 29.98 15.53 39 15942 40963 79687444
Ketosis 28.14 15.53 10 15971 1116 79727291
Impaired gastric emptying 27.40 15.53 20 15961 10333 79718074
Abdominal pain 26.85 15.53 151 15830 389418 79338989
Wrong drug 26.46 15.53 7 15974 289 79728118
Systemic infection 26.18 15.53 19 15962 9733 79718674
Blood calcitonin increased 26.07 15.53 5 15976 45 79728362
Thirst decreased 26.07 15.53 7 15974 306 79728101
Injection site urticaria 25.69 15.53 21 15960 12805 79715602
Product monitoring error 25.39 15.53 18 15963 8888 79719519
Febrile neutropenia 24.29 15.53 8 15973 230991 79497416
Off label use 22.85 15.53 99 15882 907116 78821291
Diabetic ketosis 22.83 15.53 7 15974 493 79727914
Pneumonia 22.72 15.53 63 15918 660183 79068224
Gastric dilatation 22.48 15.53 9 15972 1393 79727014
Infusion related reaction 22.47 15.53 9 15972 230228 79498179
Drug ineffective 22.06 15.53 127 15854 1080786 78647621
Injection site nodule 21.91 15.53 12 15969 3768 79724639
Joint swelling 21.34 15.53 16 15965 288630 79439777
Hyperglycaemic hyperosmolar nonketotic syndrome 21.22 15.53 10 15971 2293 79726114
Coronavirus test positive 20.75 15.53 8 15973 1121 79727286
Neck dissection 20.47 15.53 3 15978 3 79728404
Platelet count decreased 20.02 15.53 7 15974 194657 79533750
Cholelithiasis 19.99 15.53 37 15944 52627 79675780
Urine ketone body present 19.79 15.53 11 15970 3554 79724853
Dysuria 19.59 15.53 36 15945 50915 79677492
Contraindicated product administered 19.33 15.53 4 15977 157534 79570873
Device difficult to use 18.96 15.53 18 15963 13367 79715040
Arthropathy 18.86 15.53 6 15975 177105 79551302
Accidental exposure to product 18.68 15.53 27 15954 31295 79697112
Gangrene 18.64 15.53 15 15966 8949 79719458
Lumbosacral radiculoplexus neuropathy 18.35 15.53 4 15977 71 79728336
Idiopathic interstitial pneumonia 18.23 15.53 5 15976 237 79728170
Injection site swelling 17.75 15.53 33 15948 47099 79681308
Amylase increased 17.67 15.53 16 15965 11193 79717214
Hyperamylasaemia 17.15 15.53 7 15974 1140 79727267
Pancytopenia 16.97 15.53 6 15975 165739 79562668
Increased appetite 16.76 15.53 16 15965 11962 79716445
Disease progression 16.73 15.53 8 15973 184354 79544053
Pulmonary oedema 16.65 15.53 47 15934 88207 79640200
Injection site reaction 16.58 15.53 35 15946 54750 79673657
Toe amputation 16.25 15.53 10 15971 3901 79724506
Flatulence 16.19 15.53 30 15951 42694 79685713
Product storage error 16.06 15.53 18 15963 16208 79712199
Injection site discomfort 16.03 15.53 11 15970 5155 79723252
Malignant neoplasm progression 15.59 15.53 4 15977 135986 79592421
Echocardiogram abnormal 15.53 15.53 8 15973 2220 79726187

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BJ05 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Glucagon-like peptide-1 (GLP-1) analogues
FDA CS M0160181 Glucagon-Like Peptide 1
FDA MoA N0000020058 Glucagon-like Peptide-1 (GLP-1) Agonists
FDA EPC N0000178480 GLP-1 Receptor Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucagon-like peptide 1 receptor GPCR AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
WTT295HSY5 UNII
D09889 KEGG_DRUG
4033739 VUID
N0000191089 NUI
4033739 VANDF
C3179549 UMLSCUI
CHEMBL2108027 ChEMBL_ID
DB09045 DRUGBANK_ID
9164 INN_ID
C555680 MESH_SUPPLEMENTAL_RECORD_UI
7638 IUPHAR_LIGAND_ID
1551291 RXNORM
228834 MMSL
30573 MMSL
d08290 MMSL
015693 NDDF
714080005 SNOMEDCT_US
714081009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-1433 INJECTION, SOLUTION 0.75 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-1433 INJECTION, SOLUTION 0.75 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-1433 INJECTION, SOLUTION 0.75 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-1434 INJECTION, SOLUTION 1.50 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-1434 INJECTION, SOLUTION 1.50 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-1434 INJECTION, SOLUTION 1.50 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-2236 INJECTION, SOLUTION 3 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-2236 INJECTION, SOLUTION 3 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-2236 INJECTION, SOLUTION 3 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-3182 INJECTION, SOLUTION 4.50 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-3182 INJECTION, SOLUTION 4.50 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 0002-3182 INJECTION, SOLUTION 4.50 mg SUBCUTANEOUS BLA 36 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 50090-3483 INJECTION, SOLUTION 1.50 mg SUBCUTANEOUS BLA 35 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 50090-3483 INJECTION, SOLUTION 1.50 mg SUBCUTANEOUS BLA 35 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 50090-3484 INJECTION, SOLUTION 0.75 mg SUBCUTANEOUS BLA 35 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 50090-3484 INJECTION, SOLUTION 0.75 mg SUBCUTANEOUS BLA 35 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 50090-5467 INJECTION, SOLUTION 3 mg SUBCUTANEOUS BLA 35 sections
Trulicity HUMAN PRESCRIPTION DRUG LABEL 1 50090-5467 INJECTION, SOLUTION 3 mg SUBCUTANEOUS BLA 35 sections
TRULICITY HUMAN PRESCRIPTION DRUG LABEL 1 50090-6453 INJECTION, SOLUTION 0.75 mg SUBCUTANEOUS BLA 34 sections
TRULICITY HUMAN PRESCRIPTION DRUG LABEL 1 50090-6456 INJECTION, SOLUTION 1.50 mg SUBCUTANEOUS BLA 34 sections
TRULICITY HUMAN PRESCRIPTION DRUG LABEL 1 50090-6571 INJECTION, SOLUTION 3 mg SUBCUTANEOUS BLA 34 sections